IL129100A - Methods for use in producing paclitaxel - Google Patents

Methods for use in producing paclitaxel

Info

Publication number
IL129100A
IL129100A IL12910097A IL12910097A IL129100A IL 129100 A IL129100 A IL 129100A IL 12910097 A IL12910097 A IL 12910097A IL 12910097 A IL12910097 A IL 12910097A IL 129100 A IL129100 A IL 129100A
Authority
IL
Israel
Prior art keywords
cbz
intermediate compound
producing
benzyl
protected
Prior art date
Application number
IL12910097A
Other languages
English (en)
Other versions
IL129100A0 (en
Original Assignee
Napro Biotherapeutics Inc
Bryn Mawr College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Napro Biotherapeutics Inc, Bryn Mawr College filed Critical Napro Biotherapeutics Inc
Priority to IL15304397A priority Critical patent/IL153043A/en
Priority to IL14886397A priority patent/IL148863A0/xx
Publication of IL129100A0 publication Critical patent/IL129100A0/xx
Publication of IL129100A publication Critical patent/IL129100A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL12910097A 1996-09-25 1997-09-25 Methods for use in producing paclitaxel IL129100A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL15304397A IL153043A (en) 1996-09-25 1997-09-25 Intermediate for baccatin iii derivatives and methods for the production thereof
IL14886397A IL148863A0 (en) 1996-09-25 1997-09-25 Components for use in producing paclitaxal and methods for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/719,488 US5750737A (en) 1996-09-25 1996-09-25 Method for paclitaxel synthesis
PCT/US1997/017230 WO1998013360A1 (en) 1996-09-25 1997-09-25 Method for paclitaxel synthesis

Publications (2)

Publication Number Publication Date
IL129100A0 IL129100A0 (en) 2000-02-17
IL129100A true IL129100A (en) 2004-03-28

Family

ID=24890263

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12910097A IL129100A (en) 1996-09-25 1997-09-25 Methods for use in producing paclitaxel

Country Status (10)

Country Link
US (2) US5750737A (enExample)
EP (1) EP0935596B1 (enExample)
JP (1) JP2001501613A (enExample)
CN (2) CN1097586C (enExample)
AT (1) ATE288427T1 (enExample)
AU (1) AU736591B2 (enExample)
CA (1) CA2266892C (enExample)
DE (1) DE69732421D1 (enExample)
IL (1) IL129100A (enExample)
WO (1) WO1998013360A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973170A (en) * 1996-09-25 1999-10-26 Napro Biotherapuetics, Inc. C-7 metal alkoxides of baccatin III
CN100348589C (zh) * 1998-05-01 2007-11-14 梅思医药（美国）股份有限公司 从c－7,c－10双苄酯基浆果赤霉素iii合成红豆杉醇的方法和有用的中间体
US6002025A (en) * 1999-02-24 1999-12-14 Bcm Developement Inc. Method for the purification of taxanes
US6143902A (en) * 1999-06-21 2000-11-07 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
US6136999A (en) * 1999-06-21 2000-10-24 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
CA2375343A1 (en) * 1999-06-21 2000-12-28 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof
US20040115134A1 (en) * 1999-06-22 2004-06-17 Elan Pharma International Ltd. Novel nifedipine compositions
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US6358996B1 (en) * 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
EP1383492A4 (en) * 2001-03-23 2008-12-24 Napro Biotherapeutics Inc MOLECULAR CONJUGATES FOR USE IN CANCER THERAPY
US6479679B1 (en) * 2001-04-25 2002-11-12 Napro Biotherapeutics, Inc. Two-step conversion of protected taxane ester to paclitaxel
US6452025B1 (en) * 2001-04-25 2002-09-17 Napro Biotherapeutics, Inc. Three-step conversion of protected taxane ester to paclitaxel
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
CA2479665C (en) * 2002-03-20 2011-08-30 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
JP2009521435A (ja) * 2005-12-21 2009-06-04 タペストリー ファーマシューティカルズ インコーポレーテッド タキサンを形成するための新規化合物および方法ならびにその使用
JP2009531446A (ja) * 2006-03-27 2009-09-03 タペストリー ファーマシューティカルズ インコーポレーテッド タキサン誘導体の合成のためのコンバージェントプロセス
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
TW201127384A (en) * 2009-11-18 2011-08-16 Nerviano Medical Sciences Srl Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34277A (en) * 1862-01-28 Improvement in lamps
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
USRE34277E (en) * 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
FR2680506B1 (fr) * 1991-08-19 1994-09-02 Rhone Poulenc Rorer Sa Procede de preparation de derives de la beta-phenylisoserine et leur utilisation.
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
FR2687151B1 (fr) * 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
EP1260507A1 (en) * 1993-02-05 2002-11-27 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable A-nng side chains

Also Published As

Publication number Publication date
US5750737A (en) 1998-05-12
ATE288427T1 (de) 2005-02-15
AU4502197A (en) 1998-04-17
IL129100A0 (en) 2000-02-17
JP2001501613A (ja) 2001-02-06
CA2266892A1 (en) 1998-04-02
CA2266892C (en) 2005-12-06
EP0935596B1 (en) 2005-02-02
EP0935596A4 (en) 1999-10-27
CN1097586C (zh) 2003-01-01
CN1230953A (zh) 1999-10-06
CN1440967A (zh) 2003-09-10
AU736591B2 (en) 2001-08-02
DE69732421D1 (de) 2005-03-10
WO1998013360A1 (en) 1998-04-02
US6133462A (en) 2000-10-17
EP0935596A1 (en) 1999-08-18

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Publication Publication Date Title
US5688977A (en) Method for docetaxel synthesis
EP0935596B1 (en) Method for paclitaxel synthesis
WO1996040666A1 (en) Paclitaxel synthesis from precursor compounds and methods of producing the same
EP0837846A1 (en) C-2' hydroxyl-benzyl protected, n-carbamate protected (2r,3s)-3-phenylisoserine and production process therefor
US6107497A (en) Intermediate for use in docetaxel synthesis and production method therefor
US5973170A (en) C-7 metal alkoxides of baccatin III
AU745731B2 (en) Methods and useful intermediates for paclitaxel synthesis from C-7, C-10 di-CBZ baccatin III
IL153043A (en) Intermediate for baccatin iii derivatives and methods for the production thereof
MXPA99002793A (en) Method for paclitaxel synthesis
CA2375343A1 (en) C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof
MXPA00010678A (es) Metodos e intermediarios utiles para la sintesis de paclitaxel a partir de di-cbz bacatina iii de c-7, c-10

Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees