CN109730697A - 用于收集体液样品的装置 - Google Patents
用于收集体液样品的装置 Download PDFInfo
- Publication number
- CN109730697A CN109730697A CN201910039799.8A CN201910039799A CN109730697A CN 109730697 A CN109730697 A CN 109730697A CN 201910039799 A CN201910039799 A CN 201910039799A CN 109730697 A CN109730697 A CN 109730697A
- Authority
- CN
- China
- Prior art keywords
- sample
- vessel
- channel
- collection
- vessels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001124 body fluid Anatomy 0.000 title claims description 318
- 239000012530 fluid Substances 0.000 claims abstract description 417
- 238000004891 communication Methods 0.000 claims abstract description 189
- 210000004369 blood Anatomy 0.000 claims description 259
- 239000008280 blood Substances 0.000 claims description 258
- 239000000463 material Substances 0.000 claims description 180
- 239000003146 anticoagulant agent Substances 0.000 claims description 161
- 229940127219 anticoagulant drug Drugs 0.000 claims description 161
- 230000003287 optical effect Effects 0.000 claims description 107
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 62
- 229920000669 heparin Polymers 0.000 claims description 54
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 53
- 229960002897 heparin Drugs 0.000 claims description 53
- 230000009471 action Effects 0.000 claims description 41
- 238000012546 transfer Methods 0.000 claims description 41
- 238000000576 coating method Methods 0.000 claims description 35
- 230000033001 locomotion Effects 0.000 claims description 33
- 239000011248 coating agent Substances 0.000 claims description 27
- 230000037361 pathway Effects 0.000 claims description 21
- 230000000007 visual effect Effects 0.000 claims description 17
- 230000014759 maintenance of location Effects 0.000 claims description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000000926 separation method Methods 0.000 abstract description 16
- 239000000523 sample Substances 0.000 description 2395
- 238000000034 method Methods 0.000 description 228
- 238000012545 processing Methods 0.000 description 163
- 238000003556 assay Methods 0.000 description 140
- 230000000670 limiting effect Effects 0.000 description 121
- 238000003860 storage Methods 0.000 description 120
- 210000001519 tissue Anatomy 0.000 description 110
- 239000000306 component Substances 0.000 description 101
- 230000000149 penetrating effect Effects 0.000 description 92
- 239000010839 body fluid Substances 0.000 description 76
- 238000001514 detection method Methods 0.000 description 72
- 230000032258 transport Effects 0.000 description 72
- 230000007246 mechanism Effects 0.000 description 49
- 210000002381 plasma Anatomy 0.000 description 49
- 210000004027 cell Anatomy 0.000 description 44
- 238000012360 testing method Methods 0.000 description 44
- 238000010790 dilution Methods 0.000 description 43
- 239000012895 dilution Substances 0.000 description 43
- 239000007788 liquid Substances 0.000 description 39
- 238000006243 chemical reaction Methods 0.000 description 37
- 238000009533 lab test Methods 0.000 description 37
- 239000012782 phase change material Substances 0.000 description 37
- 230000008569 process Effects 0.000 description 35
- 239000012470 diluted sample Substances 0.000 description 33
- 239000003550 marker Substances 0.000 description 33
- 238000001816 cooling Methods 0.000 description 31
- 239000003570 air Substances 0.000 description 29
- 238000011049 filling Methods 0.000 description 29
- 239000000126 substance Substances 0.000 description 29
- 238000004458 analytical method Methods 0.000 description 28
- 208000027418 Wounds and injury Diseases 0.000 description 25
- 239000003153 chemical reaction reagent Substances 0.000 description 25
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 238000002360 preparation method Methods 0.000 description 22
- 238000006467 substitution reaction Methods 0.000 description 22
- 102000039446 nucleic acids Human genes 0.000 description 21
- 108020004707 nucleic acids Proteins 0.000 description 21
- 230000000712 assembly Effects 0.000 description 20
- 238000000429 assembly Methods 0.000 description 20
- 230000036961 partial effect Effects 0.000 description 19
- 239000012491 analyte Substances 0.000 description 17
- 239000000243 solution Substances 0.000 description 17
- 239000010410 layer Substances 0.000 description 16
- 230000002829 reductive effect Effects 0.000 description 16
- 230000005484 gravity Effects 0.000 description 15
- 230000036541 health Effects 0.000 description 15
- 239000007787 solid Substances 0.000 description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- 230000003321 amplification Effects 0.000 description 13
- 230000008859 change Effects 0.000 description 13
- 239000003085 diluting agent Substances 0.000 description 13
- 238000003199 nucleic acid amplification method Methods 0.000 description 13
- 238000005119 centrifugation Methods 0.000 description 12
- 238000009826 distribution Methods 0.000 description 12
- 239000007789 gas Substances 0.000 description 12
- 239000000499 gel Substances 0.000 description 12
- 238000011068 loading method Methods 0.000 description 12
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 11
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 11
- 238000003384 imaging method Methods 0.000 description 11
- 210000002700 urine Anatomy 0.000 description 11
- 239000000654 additive Substances 0.000 description 10
- 238000004163 cytometry Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 150000002632 lipids Chemical class 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 108060006698 EGF receptor Proteins 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 230000002209 hydrophobic effect Effects 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 210000003296 saliva Anatomy 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 9
- 238000012800 visualization Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000011324 bead Substances 0.000 description 8
- 210000004204 blood vessel Anatomy 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
- 230000004048 modification Effects 0.000 description 8
- 239000012898 sample dilution Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 102100027211 Albumin Human genes 0.000 description 7
- -1 but not limited to Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 229920001971 elastomer Polymers 0.000 description 7
- 238000003018 immunoassay Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000008093 supporting effect Effects 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 108020004206 Gamma-glutamyltransferase Proteins 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 235000015429 Mirabilis expansa Nutrition 0.000 description 6
- 244000294411 Mirabilis expansa Species 0.000 description 6
- 230000033228 biological regulation Effects 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 6
- 238000007710 freezing Methods 0.000 description 6
- 230000008014 freezing Effects 0.000 description 6
- 230000004927 fusion Effects 0.000 description 6
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 description 6
- 238000004020 luminiscence type Methods 0.000 description 6
- 230000002503 metabolic effect Effects 0.000 description 6
- 235000013536 miso Nutrition 0.000 description 6
- 230000002028 premature Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 5
- 238000003113 dilution method Methods 0.000 description 5
- 238000010304 firing Methods 0.000 description 5
- 102000018358 immunoglobulin Human genes 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- 230000002093 peripheral effect Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 108010010234 HDL Lipoproteins Proteins 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 238000012773 Laboratory assay Methods 0.000 description 4
- 239000002250 absorbent Substances 0.000 description 4
- 230000002745 absorbent Effects 0.000 description 4
- 238000007818 agglutination assay Methods 0.000 description 4
- 239000012080 ambient air Substances 0.000 description 4
- 238000012801 analytical assay Methods 0.000 description 4
- 239000012298 atmosphere Substances 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000005670 electromagnetic radiation Effects 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 239000000446 fuel Substances 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000000386 microscopy Methods 0.000 description 4
- 238000003752 polymerase chain reaction Methods 0.000 description 4
- 229920000136 polysorbate Polymers 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 238000013207 serial dilution Methods 0.000 description 4
- 238000007493 shaping process Methods 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 230000026676 system process Effects 0.000 description 4
- 210000003371 toe Anatomy 0.000 description 4
- 239000003981 vehicle Substances 0.000 description 4
- 238000001429 visible spectrum Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000001133 acceleration Effects 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 3
- 238000011166 aliquoting Methods 0.000 description 3
- 238000000149 argon plasma sintering Methods 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 210000003103 bodily secretion Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 239000012611 container material Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000012864 cross contamination Methods 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 238000005429 filling process Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000003908 liver function Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000007826 nucleic acid assay Methods 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 238000002203 pretreatment Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 210000001138 tear Anatomy 0.000 description 3
- 239000012780 transparent material Substances 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical compound C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 description 2
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 2
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 2
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
- 238000007397 LAMP assay Methods 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 2
- 108010062497 VLDL Lipoproteins Proteins 0.000 description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003698 antivitamin K Substances 0.000 description 2
- 239000008228 bacteriostatic water for injection Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000005415 bioluminescence Methods 0.000 description 2
- 230000029918 bioluminescence Effects 0.000 description 2
- 239000008366 buffered solution Substances 0.000 description 2
- 229920005549 butyl rubber Polymers 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 238000007822 cytometric assay Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 230000012953 feeding on blood of other organism Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000002783 friction material Substances 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 230000002977 hyperthermial effect Effects 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 210000001739 intranuclear inclusion body Anatomy 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 229920001463 polyanetholesulfonic acid sodium salt Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- APTZNLHMIGJTEW-UHFFFAOYSA-N pyraflufen-ethyl Chemical compound C1=C(Cl)C(OCC(=O)OCC)=CC(C=2C(=C(OC(F)F)N(C)N=2)Cl)=C1F APTZNLHMIGJTEW-UHFFFAOYSA-N 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 210000000352 storage cell Anatomy 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 230000036962 time dependent Effects 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 229940019333 vitamin k antagonists Drugs 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- NNKSRGUMPLVLGD-UHFFFAOYSA-N 2-[[2-(2-ethylbutoxy)-2,2-diphenylacetyl]-methylamino]ethyl-dimethylazanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1C(C(=O)N(C)CC[NH+](C)C)(OCC(CC)CC)C1=CC=CC=C1 NNKSRGUMPLVLGD-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010050337 Cerumen impaction Diseases 0.000 description 1
- 229920000114 Corrugated plastic Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 238000008789 Direct Bilirubin Methods 0.000 description 1
- 208000017701 Endocrine disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000004221 Multiple Trauma Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 206010051077 Post procedural haemorrhage Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 108010069201 VLDL Cholesterol Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 210000000617 arm Anatomy 0.000 description 1
- 238000013096 assay test Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000013142 basic testing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000009582 blood typing Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 108091006374 cAMP receptor proteins Proteins 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 210000002939 cerumen Anatomy 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000007820 coagulation assay Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000007398 colorimetric assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000004795 extruded polystyrene foam Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000504 luminescence detection Methods 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 230000010358 mechanical oscillation Effects 0.000 description 1
- 210000001006 meconium Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000012778 molding material Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000929 nociceptor Anatomy 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 210000004915 pus Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000007811 spectroscopic assay Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 210000005010 torso Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000007817 turbidimetric assay Methods 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- FUTVBRXUIKZACV-UHFFFAOYSA-J zinc;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoate Chemical compound [Zn+2].[N-]1C2=C(C)C(CCC([O-])=O)=C1C=C([N-]1)C(CCC([O-])=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 FUTVBRXUIKZACV-UHFFFAOYSA-J 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
- A61B5/154—Devices using pre-evacuated means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150305—Packages specially adapted for piercing devices or blood sampling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150992—Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; Blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings or valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/90—Identification means for patients or instruments, e.g. tags
- A61B90/94—Identification means for patients or instruments, e.g. tags coded with symbols, e.g. text
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/90—Identification means for patients or instruments, e.g. tags
- A61B90/98—Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/90—Identification means for patients or instruments, e.g. tags
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Ecology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Electromagnetism (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261733886P | 2012-12-05 | 2012-12-05 | |
| US61/733,886 | 2012-12-05 | ||
| US201361786351P | 2013-03-15 | 2013-03-15 | |
| US201361852489P | 2013-03-15 | 2013-03-15 | |
| US61/852,489 | 2013-03-15 | ||
| US61/786,351 | 2013-03-15 | ||
| US201361875030P | 2013-09-07 | 2013-09-07 | |
| US61/875,030 | 2013-09-07 | ||
| US201361875107P | 2013-09-08 | 2013-09-08 | |
| US61/875,107 | 2013-09-08 | ||
| US29/466,441 USD733314S1 (en) | 2013-09-08 | 2013-09-08 | Shipping container |
| US29/466,441 | 2013-09-08 | ||
| US29/466,442 USD733315S1 (en) | 2013-09-08 | 2013-09-08 | Shipping container |
| US29/466,442 | 2013-09-08 | ||
| US29/466,440 USD732686S1 (en) | 2013-09-08 | 2013-09-08 | Shipping container |
| US29/466,443 USD733316S1 (en) | 2013-09-08 | 2013-09-08 | Shipping container |
| US29/466,440 | 2013-09-08 | ||
| US29/466,443 | 2013-09-08 | ||
| US29/466,710 | 2013-09-10 | ||
| US29/466,710 USD733317S1 (en) | 2013-09-08 | 2013-09-10 | Shipping container |
| US29/466,739 | 2013-09-11 | ||
| US29/466,739 USD733318S1 (en) | 2013-09-08 | 2013-09-11 | Shipping container |
| CN201380072120.6A CN104968269B (zh) | 2012-12-05 | 2013-12-05 | 用于体液样品收集、运输和处理的系统、装置和方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380072120.6A Division CN104968269B (zh) | 2012-12-05 | 2013-12-05 | 用于体液样品收集、运输和处理的系统、装置和方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109730697A true CN109730697A (zh) | 2019-05-10 |
Family
ID=50884116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910039799.8A Pending CN109730697A (zh) | 2012-12-05 | 2013-12-05 | 用于收集体液样品的装置 |
| CN201380072120.6A Expired - Fee Related CN104968269B (zh) | 2012-12-05 | 2013-12-05 | 用于体液样品收集、运输和处理的系统、装置和方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380072120.6A Expired - Fee Related CN104968269B (zh) | 2012-12-05 | 2013-12-05 | 用于体液样品收集、运输和处理的系统、装置和方法 |
Country Status (10)
| Country | Link |
|---|---|
| JP (3) | JP2016505302A (enExample) |
| KR (1) | KR20150092265A (enExample) |
| CN (2) | CN109730697A (enExample) |
| AU (2) | AU2013356680A1 (enExample) |
| BR (1) | BR112015012944A2 (enExample) |
| CA (1) | CA2891513A1 (enExample) |
| IL (1) | IL239062A0 (enExample) |
| MX (1) | MX372656B (enExample) |
| SG (1) | SG11201504233RA (enExample) |
| WO (1) | WO2014088606A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013112877A1 (en) | 2012-01-25 | 2013-08-01 | Tasso, Inc. | Handheld device for drawing, collecting, and analyzing bodily fluid |
| JP6405305B2 (ja) | 2012-08-09 | 2018-10-17 | エモリー ユニバーシティ | ヘモグロビンの生理的レベルおよび／または範囲および／または疾患状態を判定するためのキットおよび方法 |
| US9636062B2 (en) | 2012-09-06 | 2017-05-02 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| US9427184B2 (en) | 2012-09-06 | 2016-08-30 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample collection |
| CA3130059A1 (en) | 2012-09-06 | 2014-03-13 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection |
| US9386948B2 (en) | 2012-12-05 | 2016-07-12 | Theranos, Inc. | Systems, devices, and methods for bodily fluid sample transport |
| US10248765B1 (en) | 2012-12-05 | 2019-04-02 | Theranos Ip Company, Llc | Systems, devices, and methods for bodily fluid sample collection, transport, and handling |
| MX365324B (es) | 2013-03-15 | 2019-05-29 | Theranos Ip Co Llc | Metodos y dispositivos para recoleccion de muestras y separacion de muestras. |
| WO2016138013A1 (en) * | 2015-02-24 | 2016-09-01 | Theranos, Inc. | Methods and systems for obtaining clinical samples |
| EP3068305A4 (en) | 2013-11-11 | 2017-06-21 | Theranos, Inc. | Methods and systems for a sample collection device with a novelty exterior |
| CN106456439B (zh) | 2014-03-12 | 2021-06-25 | 赛拉诺斯知识产权有限责任公司 | 用于体液样品收集的系统、装置和方法 |
| EP4338669A3 (en) * | 2014-08-01 | 2024-05-22 | Tasso, Inc. | Systems for gravity-enhanced microfluidic collection, handling and transferring of fluids |
| US10779757B2 (en) | 2014-08-01 | 2020-09-22 | Tasso, Inc. | Devices, systems and methods for gravity-enhanced microfluidic collection, handling and transferring of fluids |
| US20170276690A1 (en) * | 2014-08-14 | 2017-09-28 | Emory University | Visually-Based Diagnostic Device for Automatic Determination of a Physiologic Level Associated with a Sample |
| EP3325160A4 (en) * | 2015-07-21 | 2019-04-03 | Theranos, Inc. | SYSTEMS, DEVICES AND METHODS FOR DETECTING, TRANSPORTING AND HANDLING BODY FLUID SAMPLES |
| US10371606B2 (en) | 2015-07-21 | 2019-08-06 | Theraos IP Company, LLC | Bodily fluid sample collection and transport |
| FI4035762T3 (fi) | 2015-09-09 | 2023-12-04 | Drawbridge Health Inc | Laitteita näytteiden keräämistä, stabilointia ja säilytystä varten |
| WO2017044888A1 (en) | 2015-09-09 | 2017-03-16 | Theranos, Inc. | Methods and devices for sample collection and sample separation |
| WO2017143149A1 (en) | 2016-02-17 | 2017-08-24 | Polymer Technology Systems, Inc. | Systems and methods for a blood collector with enhanced volume using capillary techniques |
| JP6790556B2 (ja) * | 2016-08-01 | 2020-11-25 | 凸版印刷株式会社 | 検査ユニット |
| EP3515521B1 (en) | 2016-09-21 | 2023-10-25 | Tasso, Inc. | Fluid cartridge for delivery of bodily fluids onto a fibrous substrate |
| GB2590814B (en) | 2017-01-10 | 2021-11-03 | Drawbridge Health Inc | Devices, systems, and methods for sample collection |
| US11857966B1 (en) | 2017-03-15 | 2024-01-02 | Labrador Diagnostics Llc | Methods and devices for sample collection and sample separation |
| CN110740814B (zh) * | 2017-05-12 | 2021-11-16 | 赛默飞世尔科学有限公司 | 容器保持器和容器架 |
| CN107202878B (zh) * | 2017-05-14 | 2019-09-03 | 台州市黄岩瑞丽模塑股份有限公司 | 一种使用方便且稳定的医疗检测用尿杯的固定装置 |
| CN107063768B (zh) * | 2017-06-14 | 2023-12-22 | 深圳市傲天医疗智能系统有限公司 | 一种采血设备及其控制方法 |
| KR102005493B1 (ko) * | 2017-08-03 | 2019-10-08 | 한국전자통신연구원 | 얼굴 표정 교정 장치 및 이를 사용한 바이오 물질 분석 방법 |
| EP3672730B1 (en) | 2017-08-24 | 2022-06-29 | Innatoss Laboratories B.V. | Liquid handling system and method |
| JP7438137B2 (ja) * | 2018-05-14 | 2024-02-26 | ループ メディカル エスアー | ユーザーの流体のサンプルを抽出および採取するためのサンプル採取デバイス、システム、および方法 |
| US10739054B2 (en) * | 2018-06-28 | 2020-08-11 | Scott M Jennie | Rigid refreezable portable storage container insert |
| EP3620772B1 (en) * | 2018-09-06 | 2021-10-13 | Milestone S.r.l. | System and method for filling a closed container with a fixative solution |
| GB2582156B (en) * | 2019-03-12 | 2022-09-28 | Quantumdx Group Ltd | Specimen container for specimen pre-processing |
| CN110292961B (zh) * | 2019-07-02 | 2021-07-20 | 英诺维尔智能科技（苏州）有限公司 | 一种移液枪头密封结构 |
| CN114364986B (zh) * | 2019-09-13 | 2025-10-03 | 贝克曼库尔特有限公司 | 远程样品递送系统 |
| CN110575206B (zh) * | 2019-09-27 | 2022-02-01 | 重庆市人民医院 | 一种消化内科活体取样装置 |
| WO2021086441A1 (en) | 2019-10-31 | 2021-05-06 | Orasecure Llc | Oral fluid, saliva & sputum collection device and method |
| TWI702398B (zh) * | 2019-11-08 | 2020-08-21 | 香港商智慧生醫材料股份有限公司 | 試管 |
| TWI741843B (zh) * | 2020-10-20 | 2021-10-01 | 新加坡商億恩診斷有限公司 | 體液蛋白質濃度檢測裝置及其運作方法 |
| CN112263283B (zh) * | 2020-10-27 | 2023-08-25 | 深圳市华晨阳科技有限公司 | 咽拭子自助采样方法 |
| KR102460510B1 (ko) * | 2020-12-03 | 2022-10-27 | 부경대학교 산학협력단 | 비파괴 시료 채취장치 |
| CN112730193A (zh) * | 2020-12-23 | 2021-04-30 | 宁波大禾仪器有限公司 | 用于防护服布料的血液穿透性测试设备 |
| EP4070735A1 (en) * | 2021-04-09 | 2022-10-12 | Orasecure LLC | Oral fluid, saliva and sputum collection device |
| CN113862112B (zh) * | 2021-09-03 | 2023-08-15 | 南昌大学 | 微流控离心式挤压的细胞转染系统及细胞转染方法 |
| CN114460320B (zh) * | 2022-04-14 | 2022-06-21 | 深圳市帝迈生物技术有限公司 | 样本分析仪及其样本检测流程 |
| CN116952652B (zh) * | 2022-04-20 | 2024-08-27 | 苏州浩谱嘉自动化装备有限公司 | 一种pvc粉末产线智能取样系统 |
| CN114939450B (zh) * | 2022-06-13 | 2023-10-10 | 广州金域医学检验中心有限公司 | 试管及试管防溢判读方法 |
| CN115541817B (zh) * | 2022-09-19 | 2025-03-25 | 中铁十九局集团矿业投资有限公司 | 一种基岩面预爆裂检测装置及使用方法 |
| DE102023102184A1 (de) * | 2023-01-30 | 2024-08-01 | The smart period blood GmbH | Adapter zum Überführen und Aufbereiten einer Menstruationsausscheidungen enthaltenden Probe in ein verschließbares Probengefäß |
| WO2025137135A1 (en) * | 2023-12-21 | 2025-06-26 | Abbott Diagnostics Scarborough, Inc. | Liquid containers including primary and secondary caps |
| CN117517696B (zh) * | 2023-12-29 | 2024-03-29 | 杭州谱聚医疗科技有限公司 | 一种在线原位获取样品的系统及取样方法 |
| KR102726460B1 (ko) * | 2024-01-31 | 2024-11-05 | (주)에이티솔루션즈 | 검체 검사 의뢰기관별 통합 검체 수거 시스템 |
| CN118197584A (zh) * | 2024-05-15 | 2024-06-14 | 四川互慧软件有限公司 | 一种医疗样本送检方法及送检管理集成系统 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1088789A1 (ru) * | 1982-03-02 | 1984-04-30 | Донецкий Ордена Трудового Красного Знамени Политехнический Институт | Пипетка |
| CN2128870Y (zh) * | 1992-03-03 | 1993-03-31 | 黄永强 | 一次性使用负压血样采集器 |
| US5505721A (en) * | 1993-09-16 | 1996-04-09 | Leach; Gregory L. | Multiple tube perfusion sampler |
| US5833630A (en) * | 1994-11-03 | 1998-11-10 | Kloth; Bernd | Sample collection device |
| US20010031932A1 (en) * | 2000-04-12 | 2001-10-18 | Blake Kevin R. | Automated blood sampling apparatus |
| US20050059163A1 (en) * | 2003-08-05 | 2005-03-17 | Becton, Dickinson And Company | Device and methods for collection of biological fluid sample and treatment of selected components |
| US20060228259A1 (en) * | 2005-04-12 | 2006-10-12 | Chromodex Inc. | Joint-diagnostic spectroscopic and biosensor meter |
| CN1969184A (zh) * | 2004-04-16 | 2007-05-23 | 拉希达·A·卡马利 | 样本采集、处理和分析组件 |
| CN101321586A (zh) * | 2005-12-12 | 2008-12-10 | 西泰克公司 | 用于从基于液体的细胞学样本中获得等分试样的方法及仪器 |
| CN202288989U (zh) * | 2011-11-01 | 2012-07-04 | 石家庄诺利达医疗器械有限公司 | 负压型体液收集器 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3604410A (en) | 1968-09-11 | 1971-09-14 | Gary L Whitacre | Multitube blood sampler |
| US4150089A (en) | 1977-09-06 | 1979-04-17 | Linet Michael S | Multi-chamber test tube |
| JPS63216542A (ja) * | 1987-03-06 | 1988-09-08 | テルモ株式会社 | 採血容器及びこれを備えた採血器具 |
| JPH068557Y2 (ja) * | 1987-03-20 | 1994-03-02 | 征俊 相徳 | 検体保冷容器 |
| US5686238A (en) * | 1992-02-10 | 1997-11-11 | Baxter International Inc. | Method and device for testing blood units for viral contamination |
| JP2805463B2 (ja) * | 1995-10-17 | 1998-09-30 | 株式会社国宗工業所 | 液体混合器 |
| US5569210A (en) | 1995-11-06 | 1996-10-29 | Moen; Michael | Multiple draw syringe |
| JPH09206306A (ja) * | 1996-02-02 | 1997-08-12 | Ace Medical:Kk | 検体検査作業の処理装置 |
| US5935864A (en) * | 1996-10-07 | 1999-08-10 | Saliva Diagnostic Systems Inc. | Method and kit for collecting samples of liquid specimens for analytical testing |
| US6531098B1 (en) * | 1998-10-26 | 2003-03-11 | Drummond Scientific Company | Disposable preselected-volume, capillary pipette device having an integrally-formed bulbous end and method of taking blood samples using the device |
| JP2000193565A (ja) * | 1998-12-25 | 2000-07-14 | Sekisui Chem Co Ltd | 採血管ラック運搬用トレ― |
| JP3093189U (ja) * | 2002-10-02 | 2003-04-18 | 有限会社生理科学研究所 | 微量血液採取・分注器 |
| US20040193072A1 (en) * | 2003-03-28 | 2004-09-30 | Allen John J. | Method of analyte measurement using integrated lance and strip |
| EP3851030B1 (en) | 2003-09-11 | 2024-01-17 | Labrador Diagnostics LLC | Medical device for analyte monitoring |
| SE0303249D0 (sv) * | 2003-12-02 | 2003-12-02 | Inst Polymerutveckling Ab | Hematocrit and analyte concentration determination |
| JP2007167123A (ja) * | 2005-12-19 | 2007-07-05 | Fujifilm Corp | 真空採血管 |
| JP4758307B2 (ja) * | 2006-09-07 | 2011-08-24 | 株式会社日立ハイテクノロジーズ | 検体搬送用ラック及び分析システム |
| JP2008099989A (ja) * | 2006-10-20 | 2008-05-01 | Olympus Corp | 採血装置保持具 |
| CN200994789Y (zh) * | 2006-12-31 | 2007-12-26 | 刘国华 | 带有条形码的采血管 |
| MX352987B (es) | 2007-10-02 | 2017-12-15 | Theranos Ip Co Llc | Dispositivos modulares de punto de cuidado y usos de los mismos. |
| CN101991424B (zh) * | 2009-08-21 | 2014-06-18 | 广州阳普医疗科技股份有限公司 | 静脉血采集方法及设备 |
| EP2548507B1 (en) * | 2010-03-15 | 2014-11-26 | Takahito Matumura | Vacuum blood collection tube, blood collection unit and device for discriminating test methods |
| US8380541B1 (en) | 2011-09-25 | 2013-02-19 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
-
2013
- 2013-12-05 WO PCT/US2013/000268 patent/WO2014088606A2/en not_active Ceased
- 2013-12-05 CN CN201910039799.8A patent/CN109730697A/zh active Pending
- 2013-12-05 SG SG11201504233RA patent/SG11201504233RA/en unknown
- 2013-12-05 AU AU2013356680A patent/AU2013356680A1/en not_active Abandoned
- 2013-12-05 JP JP2015546443A patent/JP2016505302A/ja not_active Withdrawn
- 2013-12-05 KR KR1020157017793A patent/KR20150092265A/ko not_active Withdrawn
- 2013-12-05 CN CN201380072120.6A patent/CN104968269B/zh not_active Expired - Fee Related
- 2013-12-05 BR BR112015012944A patent/BR112015012944A2/pt active Search and Examination
- 2013-12-05 CA CA2891513A patent/CA2891513A1/en active Pending
- 2013-12-05 MX MX2015007134A patent/MX372656B/es active IP Right Grant
-
2015
- 2015-05-28 IL IL239062A patent/IL239062A0/en unknown
-
2018
- 2018-08-21 AU AU2018220026A patent/AU2018220026A1/en not_active Abandoned
-
2019
- 2019-08-19 JP JP2019149745A patent/JP2019205911A/ja not_active Withdrawn
-
2021
- 2021-08-06 JP JP2021129577A patent/JP2021178210A/ja active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1088789A1 (ru) * | 1982-03-02 | 1984-04-30 | Донецкий Ордена Трудового Красного Знамени Политехнический Институт | Пипетка |
| CN2128870Y (zh) * | 1992-03-03 | 1993-03-31 | 黄永强 | 一次性使用负压血样采集器 |
| US5505721A (en) * | 1993-09-16 | 1996-04-09 | Leach; Gregory L. | Multiple tube perfusion sampler |
| US5833630A (en) * | 1994-11-03 | 1998-11-10 | Kloth; Bernd | Sample collection device |
| US20010031932A1 (en) * | 2000-04-12 | 2001-10-18 | Blake Kevin R. | Automated blood sampling apparatus |
| US20050059163A1 (en) * | 2003-08-05 | 2005-03-17 | Becton, Dickinson And Company | Device and methods for collection of biological fluid sample and treatment of selected components |
| CN1969184A (zh) * | 2004-04-16 | 2007-05-23 | 拉希达·A·卡马利 | 样本采集、处理和分析组件 |
| US20060228259A1 (en) * | 2005-04-12 | 2006-10-12 | Chromodex Inc. | Joint-diagnostic spectroscopic and biosensor meter |
| CN101321586A (zh) * | 2005-12-12 | 2008-12-10 | 西泰克公司 | 用于从基于液体的细胞学样本中获得等分试样的方法及仪器 |
| CN202288989U (zh) * | 2011-11-01 | 2012-07-04 | 石家庄诺利达医疗器械有限公司 | 负压型体液收集器 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015007134A (es) | 2016-02-05 |
| MX372656B (es) | 2020-04-01 |
| CN104968269A (zh) | 2015-10-07 |
| BR112015012944A2 (pt) | 2017-07-11 |
| KR20150092265A (ko) | 2015-08-12 |
| JP2021178210A (ja) | 2021-11-18 |
| SG11201504233RA (en) | 2015-06-29 |
| AU2018220026A1 (en) | 2018-09-06 |
| HK1215848A1 (zh) | 2016-09-23 |
| JP2016505302A (ja) | 2016-02-25 |
| JP2019205911A (ja) | 2019-12-05 |
| WO2014088606A3 (en) | 2014-08-07 |
| CN104968269B (zh) | 2019-02-15 |
| IL239062A0 (en) | 2015-07-30 |
| WO2014088606A2 (en) | 2014-06-12 |
| CA2891513A1 (en) | 2014-06-12 |
| AU2013356680A1 (en) | 2015-05-28 |
| WO2014088606A8 (en) | 2015-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11305275B2 (en) | Bodily fluid sample collection and transport | |
| CN104968269B (zh) | 用于体液样品收集、运输和处理的系统、装置和方法 | |
| US10248765B1 (en) | Systems, devices, and methods for bodily fluid sample collection, transport, and handling | |
| US20140358036A1 (en) | Bodily Fluid Sample Collection and Transport | |
| US20140342371A1 (en) | Bodily Fluid Sample Collection and Transport | |
| US20170023546A1 (en) | Systems, devices, and methods for bodily fluid sample collection, transport, and handling | |
| EP2928374B1 (en) | Device for bodily fluid sample collection | |
| JP2021099372A (ja) | 体液サンプル収集、輸送および取扱いのためのシステム、機器、ならびに方法 | |
| JP2020106540A (ja) | 体液サンプル収集のためのシステム、機器、及び方法 | |
| CN104768516B (zh) | 用于体液样品收集的系统、装置和方法 | |
| CA2903839C (en) | Systems, devices, and methods for bodily fluid sample collection | |
| EP3359115A1 (en) | Bodily fluid sample collection and transport | |
| HK40031249A (en) | Systems, devices, and methods for bodily fluid sample collection and transport | |
| HK40008462A (en) | Devices for bodily fluid sample collection | |
| HK1215848B (zh) | 用於體液樣品收集、運輸和處理的系統、裝置和方法 | |
| HK1255282A1 (en) | Systems, devices, and methods for bodily fluid sample collection, transport, and handling | |
| HK1234645B (zh) | 用於体液样品收集的系统、装置和方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40008462 Country of ref document: HK |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190510 |