CN109718316A - A kind of Chinese medicine composition and preparation method thereof for treating non-alcohol fatty liver - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating non-alcohol fatty liver Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition and preparation method thereof for treating non-alcohol fatty liver, the parts by weight of each raw material in the Chinese medicine composition are as follows: 13-18 parts of red yeast rice, 10-15 parts of red ginseng, 3-8 parts of muskmelon pedicel, 10-15 parts of radix bupleuri, 15-20 parts of dandelion, 10-15 parts of rhizoma alismatis, 15-20 parts of oriental wormwood, 10-15 parts of the coptis, 10-15 parts of radix scutellariae, 15-20 parts of fructus lycii, 10-15 parts of dried orange peel, 5-10 parts of prepared RHIZOMA PINELLIZE without adju-vant and 13-18 parts of Poria cocos.A kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver includes that classification of TCD decocts, and is then sterilized.The present invention bulk pharmaceutical chemicals small using toxic side effect, raw material is easy to get, cheap.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of Chinese traditional medicine composition for treating non-alcohol fatty liver
Object and preparation method thereof.
Background technique
Except non-alcohol fatty liver refers to caused by the damage liver factor of alcohol and other clear reasons, lesion main body
In lobuli hepatis, the clinical pathology syndrome for pathological characters is stored up with diffusivity cell Macrovesicular steatosis and fat.Not only
Hepatopathy can be caused disabled and dead, also with metabolic syndrome, diabetes B, arteriosclerotic cardiovascular disease and Colon and rectum
Tumour etc. is high-incidence closely related.With fat and metabolic syndrome prevalence, non-alcohol fatty liver has become China
The first cause of first big chronic liver disease and Physical Examination liver enzyme exception seriously endangers people's life health.Because of the complexity of the disease
The uncertainty of property and pathogenesis, doctor trained in Western medicine still lack the drug for having unique curative effect to it, and other Chinese medicine compositions and its system
There is the defects for the treatment of cycle is long mostly in Preparation Method.
Summary of the invention
To solve the above problems, the present invention provides a kind of short treating period, the non-alcohol for the treatment of that therapeutic effect is good, toxic side effect is small
The Chinese medicine composition and preparation method thereof of property fatty liver disease.
The technical scheme is that
A kind of Chinese medicine composition for treating non-alcohol fatty liver, the parts by weight of each raw material in the Chinese medicine composition
Are as follows: 13-18 parts of red yeast rice, 10-15 parts of red ginseng, 3-8 parts of muskmelon pedicel, 10-15 parts of radix bupleuri, 15-20 parts of dandelion, 10-15 parts of rhizoma alismatis,
15-20 parts of oriental wormwood, 10-15 parts of the coptis, 10-15 parts of radix scutellariae, 15-20 parts of fructus lycii, 10-15 parts of dried orange peel, 5-10 parts of prepared RHIZOMA PINELLIZE without adju-vant and
13-18 parts of Poria cocos.
Further, in the Chinese medicine composition each raw material parts by weight are as follows: 15 parts of red yeast rice, 12 parts of red ginseng, muskmelon
6 parts of the base of a fruit, 12 parts of radix bupleuri, 18 parts of dandelion, 12 parts of rhizoma alismatis, 20 parts of oriental wormwood, 12 parts of the coptis, 12 parts of radix scutellariae, 20 parts of fructus lycii, dried orange peel
12 parts, 9 parts of prepared RHIZOMA PINELLIZE without adju-vant and 15 parts of Poria cocos.
Further, in the Chinese medicine composition each raw material parts by weight are as follows: 13-18 parts of red yeast rice, red ginseng 10-15
Part, hawthorn 15-20,15-20 parts of seaweed, 15-20 parts of purslane, 3-8 parts of muskmelon pedicel, 10-15 parts of radix bupleuri, 15-20 parts of dandelion,
10-15 parts of rhizoma alismatis, 15-20 parts of oriental wormwood, 10-15 parts of the coptis, 10-15 parts of radix scutellariae, 15-20 parts of fructus lycii, 1-6 parts of peppermint, dried orange peel
10-15 parts, 5-10 parts of prepared RHIZOMA PINELLIZE without adju-vant and 13-18 parts of Poria cocos.
Further, in the Chinese medicine composition each raw material parts by weight are as follows: 15 parts of red yeast rice, 12 parts of red ginseng, hawthorn
20 parts, 20 parts of seaweed, 20 parts of purslane, 6 parts of muskmelon pedicel, 12 parts of radix bupleuri, 18 parts of dandelion, 12 parts of rhizoma alismatis, 20 parts of oriental wormwood, the coptis
12 parts, 12 parts of radix scutellariae, 20 parts of fructus lycii, 3 parts of peppermint, 12 parts of dried orange peel, 9 parts of prepared RHIZOMA PINELLIZE without adju-vant and 15 parts of Poria cocos.
A kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver, mainly comprises the steps that
(1) above-mentioned parts by weight red yeast rice, red ginseng, muskmelon pedicel, radix bupleuri, dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae, fructus lycii, old is taken
Skin, prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos；
(2) dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae are put into 30 times of dandelions, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae parts by weight
It is impregnated 1 hour in clear water, half an hour is decocted after boiling；
(3) fructus lycii, dried orange peel, Poria cocos and red ginseng in step (1) are added into the medical fluid of step (2), is decocted 1 hour after boiling；
(4) prepared RHIZOMA PINELLIZE without adju-vant, muskmelon pedicel, rhizoma alismatis, red yeast rice, radix bupleuri in step (1) are added into the medical fluid of step (3), is decocted after boiling
Half an hour；
(5) filtrate is obtained by filtration in the medical fluid of step (4) while hot, the dregs of a decoction add 15 times of water to decoct filtering in 1 hour, and merging obtains twice
Filtrate obtains mixed filtrate；
(6) after the mixed filtrate that step (5) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C,
20 minutes normal-pressure sterilizations.
Further, a kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver, mainly include with
Lower step:
(1) above-mentioned parts by weight red yeast rice, red ginseng, hawthorn, seaweed, purslane, muskmelon pedicel, radix bupleuri, dandelion, rhizoma alismatis, oriental wormwood, Huang are taken
Company, radix scutellariae, fructus lycii, peppermint, dried orange peel, prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos；
(2) dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae are put into 30 times of dandelions, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae parts by weight
It is impregnated 1 hour in clear water, half an hour is decocted after boiling；
(3) fructus lycii, dried orange peel, Poria cocos and red ginseng in step (1) are added into the medical fluid of step (2), is decocted 1 hour after boiling；
(4) prepared RHIZOMA PINELLIZE without adju-vant in step (1), muskmelon pedicel, hawthorn, seaweed, purslane, rhizoma alismatis, red is added into the medical fluid of step (3)
Bent, radix bupleuri, decocts half an hour after boiling；
(5) peppermint in step (1) is added into the medical fluid of step (4), is decocted 5 minutes after boiling, filtrate, medicine is obtained by filtration while hot
Slag adds 15 times of water to decoct filtering in 1 hour, and merging obtains filtrate twice and obtains mixed filtrate；
(6) after the mixed filtrate that step (5) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C,
20 minutes normal-pressure sterilizations.
Red yeast rice: sweet in flavor, slightly warm in nature, returns spleen, large intestine, Liver Channel.There is reinforcing spleen to promote digestion, the function of activating microcirculation and removing stasis medicinal is used for eating accumulation,
Abdominal fullness and distention, red white diarrhea, prolonged lochia, traumatic injury etc..
Red ginseng: sweet in flavor, slight bitter, warm-natured, converge to the spleen channel, lung channel, the heart channel of Hang-Shaoyin, kidney channel.There is tonifying Qi enriching yin, the function of supplementing blood and promoting the production of body fluid is used
It to be taken off in physically weak, cold weak pulse of limb is Qi dysfunction in blood control, metrostaxis etc..
Hawthorn: sour, sweet, slightly warm in nature, converge to the spleen channel, stomach meridian, Liver Channel.There is the function of digestion-promoting spleen-invigorating, promoting the circulation of qi dispersing blood stasis, for meat
Stagnant, children's cream product, abdominal distention, dysentery, diarrhea, dysmenorrhea, postpartum blood stasis abdominal pain etc..
Seaweed: bitter, salty, cold in nature, return liver warp, stomach meridian, kidney channel.Have resolving hard lump, dissolving phlegm, sharp water function, for goiter,
Scrofula, testiclar gall, phlegm retention oedema etc..
Purslane: it is sour, it is cold in nature, return large intestine channel, Liver Channel.Have clearing heat and detoxicating, cooling blood and hemostasis function, for enteritis, bacillary dysentery,
Furuncle swelling toxin, snakebite and bugbite, hemorrhoid gall, eczema, erysipelas etc..
Muskmelon pedicel: bitter, cold in nature, converge to the spleen channel, stomach meridian, Liver Channel.There is the function of vomiting phlegm and indigested food by emesis, the removing jaundice that dehumidifies, for apoplexy, insane
Epilepsy, sore throat, accumulation and obstruction of sputum, the unfavorable, indigestion of breathing, chest gastral cavity distending pain, jaundice with damp-heat pathogen etc..
Radix bupleuri: bitter, cold nature, return liver warp, gallbladder channel, lung channel.Have in inducing diaphoresis, the function of soothing the liver rising Yang, for catch a cold hair
Heat, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, rectal prolapse etc..
Dandelion: bitter, cold in nature, return liver warp, stomach meridian.Have clearing heat and detoxicating, the function of diuresis dissipating bind, for acute mastitis,
Adenolymphitis, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis etc..
Rhizoma alismatis: it is sweet in flavor, light, it is cold in nature, return kidney channel, bladder meridian.There is the function of diuresis, clearing away damp-heat, is used for difficult urination, oedema
Turgor, vomiting, dysentery, phlegm retention, tinea pedis, stranguria syndrome, hematuria etc..
Oriental wormwood: bitter, pungent, cold nature, converge to the spleen channel, stomach meridian, bladder meridian.There is the function of clearing away damp-heat, removing jaundice subcutaneous ulcer, is urinated for jaundice
Less, itchy sore etc..
The coptis: bitter, cold in nature, thoughts of returning home warp, the spleen channel, stomach meridian, Liver Channel, gallbladder channel, large intestine channel.There are heat-clearing and damp-drying drug, purging fire for removing toxin
Function, for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, blood-head tells nosebleed, hot eyes, have a toothache, disappear
Yearningly, carbuncle swells furunculosis etc..
Radix scutellariae: bitter, cold in nature, distributed in lung channel, gallbladder channel, the spleen channel, large intestine channel, small intestinl channel.There is heat-clearing and damp-drying drug, purging fire for removing toxin, stop
The function of blood, miscarriage prevention is spat for damp-warm syndrome, heat temperature chest tightness and emesis, damp and hot feeling of fullness, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head
Nosebleed, carbuncle sore tumefacting virus, threatened abortion etc..
Fructus lycii: sweet in flavor, mild-natured, return liver warp, kidney channel.There is nourishing liver and kidney, benefiting shrewd head function, is used for consumption consumptive loss, waist
Knee joint soreness, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision etc..
Peppermint: acrid flavour, cool in nature, distributed in lung channel, Liver Channel.Have dispelling wind-heat, refresh oneself, promoting eruption function, be used for cold anemopyretic, head
Bitterly, hot eyes, red swelling and pain of throat, pruitus, measles without adequate eruption etc..
Dried orange peel: acrid flavour, hardship, warm-natured, converge to the spleen channel, lung channel.There are qi-regulating appetizing, eliminating dampness and eliminating phlegm function, for chest gastral cavity turgor, food
Few vomiting, coughing with a lot of sputum etc..
Prepared RHIZOMA PINELLIZE without adju-vant: acrid flavour, hardship, warm-natured, converge to the spleen channel, stomach meridian, lung channel.Have eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass it
Function, for wet phlegm and cold drink, vomiting, gastric disorder causing nausea, cough and phlegm, fullness in chest, phlegm and headache, dizziness and sleepless etc..
Poria cocos: sweet in flavor, light, mild-natured, thoughts of returning home warp, lung channel, the spleen channel, kidney channel.There is the function of clearing damp and promoting diuresis, invigorating the spleen calming heart, is used for
Edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear etc..
Without " non-alcohol fatty liver " this name of disease in traditional Chinese medicine, but can be incited somebody to action according to its pathological change and clinical manifestation
It belongs to the scopes such as " feeling of fullness ", " hypochondriac pain ", " side of body swollen ", " accumulation " and " liver ", " liver addiction ", " jaundice ", the earliest note of this disease
It is loaded in " difficult through 56 hardly possiblies ", is recorded " product of liver, name say fat gas ", refers to the excessive accumulation of the gas of fertile rouge in vivo in liver.Also
Have in " at all times doctor mirror " and records " hypochondriac pain or phlegm, product streamer mutually fight with blood in blood and are left disease ", be loaded in Miraculous Pivot " it is evil in liver, two
In the side of body bitterly, in plug, including extravesated blood ".
We are based on the turbid toxicity of Chinese medicine and control non-alcohol fatty liver by opinion.Turbid toxicity opinion thinks that turbid poison is both one kind
It to the pathogenic factor that viscera channels and collaterals and negative and positive of qi and blood can cause serious harm, while being also that many reasons lead to internal organs function
Energy disorder, QI-blood circulation are not normal, and the metabolite generated in body cannot normally be discharged in time, accumulate the product pathology of metaplasia in vivo
Product.The heresy of turbid poison refers to cuts foul heresy in vivo, all chill summer-heat and damp dryness-heat, and poly- long not dissipate, internal phlegm, the stasis of blood, water, blood, gas are long
It is strongly fragrant do not understand can change it is turbid, it is turbid to be polymerized to poison, form turbid poison.The heresy of turbid poison is resided in vivo, is become sick more.Turbid poison is mutually tied, turbid to be with poison
With, poison with it is turbid for according to, deadlocked refractory, heresy stops up channels and collaterals, and functional activity of QI being not smooth, heresy must not dissipate, and blood must not go, saliva must not cloth, saliva blood stops,
Metaplasia phlegm-turbidity and blood stasis blood, knot of mutually fighting consume viscerotrauma qi-blood-body fluid repeatedly with the passing of time, to cause the card of heap soil or fertilizer over and around the roots, the resistance of stagnation of the circulation of vital energy network in turbid poison
Machine variation, and turbid poison is concerned with for pathogenic key.Chinese medicine turbid toxicity opinion thinks non-alcohol fatty liver category " phlegm turbid, hemostasis "
Equal scopes, disease located in liver, for lesion internal organs key in liver and spleen kidney, pathogenic characteristic is asthenia in origin and asthenia in superficiality, the dirty functional disturbance of liver,spleen,kidney three
Cause to accumulate in turbid poison, causes this disease.
Usage and dosage of the invention:
Mixed liquor 300mL after taking sterilizing every time, point 2 empty stomach sub-services sooner or later.3 months are a cycle.
Invention Chinese medicine composition avoids the irritable foods such as greasy, pungent, raw and cold during taking.
Beneficial effects of the present invention:
The present invention bulk pharmaceutical chemicals small using toxic side effect, raw material is easy to get, cheap.The present invention utilizes itself spy of each drug
Point, sequentially adds in water and boils, according to every taste medicine most preferably show pharmaceutical characteristic determine tanning the time, and use cold medicine Pu
Public English, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae decoction juice decoct fructus lycii, dried orange peel, Poria cocos and red ginseng hot medicine, it is flat to reach fever and chills
Weighing apparatus adds with hawthorn, seaweed, purslane, peppermint activating microcirculation and removing stasis medicinal, resolving hard lump, clearing heat and detoxicating, the antipyretic Chinese medicine of dispelling wind, finally obtains
A kind of significant Traditional Chinese medicine composition liquid medicine for treating non-alcohol fatty liver of drug effect, thorough treatment of the present invention, toxic side effect
It is small.
Specific embodiment
Carry out the Chinese medicine composition that the present invention will be described in detail below in conjunction with specific embodiment:
A kind of 1 composition embodiment 1-5 for the Chinese medicine composition for treating non-alcohol fatty liver of the present invention of table
A kind of 2 composition embodiment 6-10 for the Chinese medicine composition for treating non-alcohol fatty liver of the present invention of table
A kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver shown in embodiment 1-5 mainly includes
Following steps:
A kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver, mainly comprises the steps that
(1) above-mentioned parts by weight red yeast rice, red ginseng, muskmelon pedicel, radix bupleuri, dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae, fructus lycii, old is taken
Skin, prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos；
(2) dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae are put into 30 times of dandelions, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae parts by weight
It is impregnated 1 hour in clear water, half an hour is decocted after boiling；
(3) fructus lycii, dried orange peel, Poria cocos and red ginseng in step (1) are added into the medical fluid of step (2), is decocted 1 hour after boiling；
(4) prepared RHIZOMA PINELLIZE without adju-vant, muskmelon pedicel, rhizoma alismatis, red yeast rice, radix bupleuri in step (1) are added into the medical fluid of step (3), is decocted after boiling
Half an hour；
(5) filtrate is obtained by filtration while hot to the medical fluid of step (4), the dregs of a decoction add 15 times of water to decoct filtering in 1 hour, and merging obtains twice
Filtrate obtains mixed filtrate；
(6) after the mixed filtrate that step (5) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C,
20 minutes normal-pressure sterilizations.
A kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver shown in embodiment 6-10, mainly
The following steps are included:
A kind of preparation method of Chinese medicine composition that treating non-alcohol fatty liver, mainly comprises the steps that
(1) above-mentioned parts by weight red yeast rice, red ginseng, hawthorn, seaweed, purslane, muskmelon pedicel, radix bupleuri, dandelion, rhizoma alismatis, oriental wormwood, Huang are taken
Company, radix scutellariae, fructus lycii, peppermint, dried orange peel, prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos；
(2) dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae are put into 30 times of dandelions, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae parts by weight
It is impregnated 1 hour in clear water, half an hour is decocted after boiling；
(3) fructus lycii, dried orange peel, Poria cocos and red ginseng in step (1) are added into the medical fluid of step (2), is decocted 1 hour after boiling；
(4) prepared RHIZOMA PINELLIZE without adju-vant in step (1), muskmelon pedicel, hawthorn, seaweed, purslane, rhizoma alismatis, red is added into the medical fluid of step (3)
Bent, radix bupleuri, decocts half an hour after boiling；
(5) peppermint in step (1) is added into the medical fluid of step (4), is decocted 5 minutes after boiling, filtrate, medicine is obtained by filtration while hot
Slag adds 15 times of water to decoct filtering in 1 hour, and merging obtains filtrate twice and obtains mixed filtrate；
(6) after the mixed filtrate that step (5) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C,
20 minutes normal-pressure sterilizations.
Clinical application
1 data and method
1.1 general information whole 90 are Hebei Prov. Traditional Chinese Medicine Hospital medical expert's consultation patient, using SAS6.12 statistical package
PROC PLAN procedure statement, give seed number, generate 90 subjects receive processing be randomly assigned table, according at random divide
3 groups are randomly divided into table.1 group 30 are treated, male 22, female 8；Age 38-55 years old, average (45.71 ± 6.51) year；Disease
Journey 1-40 months, average (22.06 ± 19.01) a month；Body mass index (BMI) (28.99 ± 3.21) kg/m2.Treat 2 groups
30, male 23, female 7；Age 38.5-54 years old, average (45.55 ± 6.38) year；It is the course of disease 1-39 months, average
(24.55 ± 15.30) a month；Body mass index (BMI) (30.49 ± 5.15) kg/m2.Control group 30, male 26, female 4
Example；Age 37-53 years old, average (44.82 ± 6.25) year；The course of disease 2-40 months, average (25.18 ± 16.55) a month；Constitution
Volume index (BMI) (32.50 ± 6.08) kg/m2.The general information such as 3 groups of Genders, age, the course of disease, body mass indexs compare
No significant difference (P05) > 0., is comparable.
1.2 case selection
1.2.1 the diagnosis of diagnostic criteria doctor trained in Western medicine is referring to Chinese Medical Association's hepatology branch fatty livers in 2010 and alcoholic liver
Diagnostic criteria in " the non-alcohol fatty liver practice guidelines " that sick group is formulated about the disease.
1.2.2 it is included in 1. diagnostic criteria that standard meets non-alcohol fatty liver；2. the age 35-55 years old；3. suffering from
For person without communication disorders, compliance is high；4. this research passes through through Hospital Ethical Committee's examination & approval, patient voluntarily receives treatment, and signs
Affix one's name to informed consent form.
1.2.3 1. exclusion criteria does not meet the diagnostic criteria of non-alcohol fatty liver；2. alcoholic liver disease
(alcoholic liver disease, ALD), chronic hepatitis C etc. can lead to the liver disease specific of fatty liver；3. drug (he
Not former times sweet smell, amiodarone, sodium vedproate, methotrexate (MTX), glucocorticoid etc.), hypothyroidism syndrome, Cushing it is comprehensive
Simulator sickness and some and lR related syndromes etc. can lead to the special circumstances of fatty liver；4. merging cardiovascular and cerebrovascular, kidney and hemopoietic system
Etc. serious diseases and mental patient；5. once suffering from acute myocardial infarction AMI, cerebrovascular accident, severe trauma or great hand in 6 months
Postoperative patient；6. because the reasons such as schooling cannot be well understood by questionnaire content person；7. mental disease, behavior disorder
Person；8. gestation, breast feeding women；9. allergic constitution and to drug allergy person.
1.3 3 groups for the treatment of methods give Primary Care.Smoking cessation；Hyperglycemia, hyperlipidemia diet are controlled, cellulose is eaten more and contains
High food, such as fresh vegetables, fruit are measured, total amount of heat intake is limited in 30 kcal/(kg d)；Adhere to hurrying up 30 daily
min。
1.3.1 it treats 1 group and gives Chinese medicine composition 1.Drug composition: 15 g of red yeast rice, 12 g of red ginseng, 6 g of muskmelon pedicel,
12 g of radix bupleuri, 18 g of dandelion, 12 g of rhizoma alismatis, 20 g of oriental wormwood, 12 g of the coptis, 12 g of radix scutellariae, 20 g of fructus lycii, 12 g of dried orange peel,
9 g of prepared RHIZOMA PINELLIZE without adju-vant, 15 g of Poria cocos.Day 1 dose, take 300 mL of juice decocting 2 times, it is point early, warmly take for evening 2 times.
1.3.2 2 groups are treated and gives Chinese medicine composition 2.Drug composition: 15 g of red yeast rice, 12 g of red ginseng, 20 g of hawthorn,
20 g of seaweed, 20 g of purslane, 6 g of muskmelon pedicel, 12 g of radix bupleuri, 18 g of dandelion, 12 g of rhizoma alismatis, 20 g of oriental wormwood, 12 g of the coptis,
12 g of radix scutellariae, 20 g of fructus lycii, 3 g of peppermint, 12 g of dried orange peel, 9 g of prepared RHIZOMA PINELLIZE without adju-vant, 15 g of Poria cocos.Day 1 dose, take juice 300 decocting 2 times
ML, point morning warmly take for evening 2 times.
1.3.3 control group gives Simvastatin Tablets (Zhejiang Jingxin Pharmaceutical Co., Ltd, national drug standard
H20030207) 10 mg, one time a day, night clothes.
1.3.4 other fat-reducing medicaments are deactivated during other 3 groups of patient's treatments, while cooperates appropriate exercise, rationally drink
Food, control weight.
1.3.5 3 groups of the course for the treatment of treatment 3 months are 1 course for the treatment of, treat 1 course for the treatment of.
Sings and symptoms change during 1.4 observation index observe patient's treatment, are controlled using automatic biochemistry analyzer detection
Treat front and back liver enzyme index serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase
(AST), gamma glutamyltransferase (γ-GT) changes, blood lipids index total cholesterol (TC), TG, high-density lipoprotein cholesterol
(HDL-C), low density lipoprotein cholesterol (LDL-C) changes.Liver imageology inspection is carried out simultaneously, before and after treatment each detection 1
It is secondary.
The recovery from illness of 1.5 criterions of therapeutical effect: clinical symptoms, sign completely disappear, and liver imageology is clearly better, liver function
It can restore normal, TC decrease beyond 20%, TG and decrease beyond 40%；Effective: clinical symptoms, sign improve or disappear, liver
Dirty iconography is clearly better, and liver function recovery is normal, and TC decrease beyond 10%-20%, and TG decrease beyond 20%-40%；It is effective:
Clinical symptoms, sign disappear substantially, and liver function returns to normal, and TC decrease beyond 10%-20%, and TG decrease beyond 20%-
40%；Invalid: clinical symptoms, sign and every inspection result do not reach the above standard or still in progress person.It is+effective+with recovery from illness to have
Effect statistics total effective rate.
1.6 iconography criterions of therapeutical effect are effective: liver imageology restores normal；It is effective: hepatic effects fatty liver degree
Compared with 1 grade of decline or more before treatment；It is invalid: not reach effective standard person.With it is effective+effectively count total effective rate.
1.7 statistical procedures application SPSS, 17.0 statistical package carries out statistical analysis, measurement data mean
± standard deviation () indicates, usestIt examines, Non-Gaussian Distribution heterogeneity of variance rank sum test, variance is examined with F together；Enumeration data
The comparison of rate uses X2It examines, ranked data compare to be analyzed using Ridit.P< 0.05 is that difference is statistically significant.
2 results
Clinical efficacy comparison is shown in Table 3 after 2.1 3 groups of treatments.
Clinical efficacy comparison example after 33 groups of treatments of table
Compared with 1 group for the treatment of, control group, *P< 0. 05
Seen from table 3,2 groups of total effective rates are treated and are higher than 1 group for the treatment of, control group (P05), comparing difference has statistics to < 0.
Meaning；Treat 1 group with control group total effective rate comparing difference it is not statistically significant (P> 0. 05).
Iconography curative effect is relatively shown in Table 4 after 2.2 3 groups of treatments.
Iconography curative effect comparative example after 43 groups of treatments of table
Compared with 1 group for the treatment of, control group, *P< 0. 05
By table 4 as it can be seen that 2 group image total effective rates for the treatment of are higher than treatment 1 group, control group (equal P < 0. 05), comparing difference has
Statistical significance；It treats 1 group and control group iconography total effective rate comparing difference is not statistically significant (P > 0. 05).
2.3 3 groups of pretherapy and post-treatment liver enzyme Indexes Comparisons are shown in Table 5.
53 groups of table pretherapy and post-treatment liver enzyme Indexes Comparison U/L,
With this group before treatment, *P< 0.05；Compared with 1 group for the treatment of, control group, △P< 0.05
By table 5 as it can be seen that reducing (P < 0. 05) before liver enzyme index ALP, ALT, AST, γ-GT relatively this group treatment after 3 groups of treatments,
Liver enzyme index ALP, ALT, AST, γ-GT are below treatment 1 group and control group (P < 0. 05) after treating 2 groups of treatments, treat 1 group
It is not statistically significant (P > 0.05) with liver enzyme index ALP, ALT, AST, γ-GT comparing difference after control group treatment.
2.4 3 groups of pretherapy and post-treatment blood lipids index are relatively shown in Table 6.
63 groups of pretherapy and post-treatment blood lipids index of table compare
With this group before treatment, *P< 0.05；Compared with 1 group for the treatment of, control group, △P< 0.05
By table 6 as it can be seen that after 3 groups of treatments blood lipids index TC, TG, LDL-C relatively this group treatment before reduce (P< 0.05), HDL-C compared with
Increased before the treatment of this group (P< 0.05)；2 groups of blood lipids index TC, TG, LDL-C are treated after treatment is below treatment 1 group and control group
(P< 0.05), HDL-C be higher than treatment 1 group and control group (P< 0.05)；Treat 1 group and control group treatment after blood lipids index TC,
TG, HDL-C, LDL-C comparing difference it is not statistically significant (P >0.05).
Pharmacodynamic study experiment
Zoopery confirms that Chinese medicine treatment can significantly reduce non-alcohol fatty liver (nonalcoholic fatty
Liver disease, NAFLD) it is alanine aminotransferase (ALT) in rat serum, aspartate aminotransferase (AST), sweet
Oily three esters (TG), total cholesterol (TC) content, effectively reverse the lipidosis state of liver, the liver of enlargement are made to bounce back.However,
It is still necessary to perfect for the research of the Chinese medicine composition 2 NAFLD curative effects to induction high in fat.To further investigate its mechanism of action, this research
Rat NAFLD model is replicated using High cholesterol diet high in fat, observes Chinese medicine composition 2 to NAFLD rat liver and items
The influence of biochemical indicator, and inquire into its mechanism of action.
1 materials and methods
1.1 material
1.1.1 experimental animal health male SD rat 50,200~240 g of weight, average (225 ± 10) g, by Hebei
It saves Experimental Animal Center to provide, animal certificate number: DK0505-0027.In air-conditioning thermostatic chamber, temperature is (22 ± 2) for raising
DEG C, humidity 40%-60%.Free water, daily 12 h of illumination.
1.1.2 2% cholesterol of high lipid food preparation, 10% lard, 0.2% propylthiouracil, 0.5% sodium taurocholate,
87% basal feed (fat, carbohydrate, protein provide 13%, 65%, 22% energy respectively).Cholesterol is purchased from upper
Marine growth chemical reagents corporation；Propylthiouracil is purchased from the state-run pharmaceutical factory in Jiangsu；Sodium taurocholate is purchased from the long limited public affairs of good fortune medicine company in Shanghai
Department；Lard, basal feed are provided by Hebei province's Experimental Animal Center.
1.1.3 (the drug composition: 15 g of red yeast rice, 12 g of red ginseng, muskmelon pedicel of experimental drug Chinese medicine composition 1
It is 6 g, 12 g of radix bupleuri, 18 g of dandelion, 12 g of rhizoma alismatis, 20 g of oriental wormwood, 12 g of the coptis, 12 g of radix scutellariae, 20 g of fructus lycii, old
12 g of skin, 9 g of prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos 15 are g).Chinese medicine composition 2 (drug composition: 15 g of red yeast rice, 12 g of red ginseng, 20 g of hawthorn,
20 g of seaweed, 20 g of purslane, 6 g of muskmelon pedicel, 12 g of radix bupleuri, 18 g of dandelion, 12 g of rhizoma alismatis, 20 g of oriental wormwood, 12 g of the coptis,
12 g of radix scutellariae, 20 g of fructus lycii, 3 g of peppermint, 12 g of dried orange peel, 9 g of prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos 15 are g).(Zhejiang capital is new for Simvastatin Tablets
Medicine company limited liability company, national drug standard H20030207).Chinese medicine composition 1, Chinese medicine composition 2 every mL medical fluids contain life
Decoction is made by Hebei Prov. Traditional Chinese Medicine Hospital Drug Manufacturing Room in 4.7 g of medicine, and required Chinese medicine is purchased from Hebei Prov. Traditional Chinese Medicine Hospital.Hydrochloric acid isopropyl kidney
Upper parathyrine (ISO) injection is purchased from Shanghai Hefeng Pharmaceutical Co., Ltd..
1.2 method
1.2.1 animal packet is by 50 after male SD rat adaptive feeding 1 week, identical experiment environment and under the conditions of it is random
Be divided into 5 groups: blank group, model group treat 1 group, treat 2 groups, positive drug control group, and each group equal 10.
1.2.2 model preparation blank group gives basal feed+common drinking water.Model group, 1 group for the treatment of, treatment 2 groups, sun
Property medicine control group gives+10% fructose water of high lipid food.After 4 weeks, 12 h rat angular vein of fasting takes blood, spot-check each group rat serum
After clear TC content, each group rat that high lipid food is fed and blank group comparing difference are statistically significant, modeling success.
1.2.3 animal administration blank group, model group give 0.9% sodium chloride injection, 100 mg/kg stomach-filling；1 group is treated to give
No. 1 100 mg/kg stomach-fillings of Chinese medicine composition；It treats 2 groups and gives No. 2 100 mg/kg stomach-fillings of Chinese medicine composition；Positive drug control group is given
2.5 mg/kg stomach-filling of Simvastatin Tablets is configured to isometric(al) suspension with 0.9 ﹪ sodium chloride injection.Claim weight, root weekly
Drug dose is adjusted according to weight.Continuous use 8 weeks, the free diet of rat during experiment.
1.2.4 rats death situation causes blank group, model group rats each dead 1 since stomach-filling operation is lack of standardization.
1.3 observation index and method
1.3.1 overview is measured and is recorded to rat weight, food-intake and inflow weekly, observes each group rat
Coat gloss, excrement, weight and the state of mind of rat.
1.3.2 after the last administration, Rat Fast can't help water to Biochemical Indexes, after the 2nd day morning Weighing body quality, abdomen
Chamber injects chloral hydrate anesthesia (0.3 mL/100 g), and angular vein takes blood 1-1.5mL, illustrates by kit, using CAT method
ALT, AST, TG, TC content are measured, detects and completes in 7180 automatic clinical chemistry analyzer of Hitachi, detection operation sequence is stringent
It is carried out according to standard requirements, detection process carries out Quality Control simultaneously.
1.4 statistical methods carry out statistical disposition, all experimental datas mean ± mark with SPSS13.0 statistical software
It is quasi- it is poor () indicate.Homogeneity test of variance is carried out to each group of data, with single factor test variance point between difference group when variance is neat
Analysis compares examined with SNK q two-by-two；Heterogeneity of variance is examined with K-W H, is compared two-by-two with Neminy method.Inspection level=0.05.
2 results
2.1 each group rat ordinary circumstances compare blank group rat behavior and enliven, and are quick on the draw, and appetite is good, fur finishing, without de-
Hair phenomenon, weight steady growth, stool is in granular form, color is yellow, matter is hard.Model group rats figure is fat, slow in reacting, fur
Fluffy and disorderly, gloss is owed in hair color jaundice, and depilation phenomenon occurs in the later period, and appetite stimulator, stool is in granular form, color is black, matter is hard；Treatment 1
Group, 2 groups for the treatment of, the decline of positive drug control group rat weight, behavior is active, is quick on the draw, and appetite is good, fur finishing, without de-
Hair phenomenon, stool matter is dilute, does not form.
2.2 each group rat weights, liver index are relatively shown in Table 7.
7 each group rat weight of table, liver index compare
Compared with blank group, *P< 0.05；Compared with model group, △P< 0.05；Compared with 1 group for the treatment of, positive drug control group, #P< 0.05
By table 7 as it can be seen that compared with blank group, model group rats weight, liver index increase (P< 0.05), illustrate modeling at
Function.Compared with model group, 1 group for the treatment of, 2 groups for the treatment of, positive drug control group weight, liver index reduce (P< 0.05), explanation
Treatment is effective.With 1 group for the treatment of, compared with positive drug control group, 2 groups of weights for the treatment of, liver index reduce it is most significant (P< 0.05),
Illustrate that 2 groups for the treatment of are better than treatment 1 group, positive drug control group.Treat 1 group it is poor with positive drug control group weight, liver index
It is different it is not statistically significant (P> 0.05).
2.3 each group rat blood serum biochemical indicators are relatively shown in Table 8.
8 each group rat blood serum biochemical indicator of table compares
Compared with blank group, *P< 0.05；Compared with model group, △P< 0.05；Compared with 1 group for the treatment of, positive drug control group, #P< 0.05
By table 8 as it can be seen that compared with blank group, model group ALT, AST, TC, TG increase (P< 0.05), illustrate modeling success.With
Model group compares, treatment 1 group, treatment 2 groups, positive drug control group ALT, AST, TC, TG reduce (P< 0.05), illustrate to treat
Effectively.With 1 group for the treatment of, compared with positive drug control group, treat 2 groups of ALT, AST, TC, TG reduce it is most significant (P< 0.05), explanation
2 groups are treated better than treatment 1 group, positive drug control group.Treat 1 group with positive drug control group ALT, AST, TC, TG comparing difference without
Statistical significance (P >0.05).
Typical case
1. patient's Mr. Wang, male, 31 years old, first visit on June 13 in 2016.Main suit: interruption right flank distending pain more than 2 years.Existing primary symptom:
It is uncomfortable to be interrupted right flank distending pain, depressed emotion swollen bored with chest gastral cavity receives difference, occasionally has lower abdominal distension, burnout out of strength, the white tongue fur thickness of tongue nature is greasy, tongue
While there is indentation, arteries and veins moistens.Liver and gallbladder ultrasound is shown: fatty liver (moderate), gallbladder polyps.Doctor trained in Western medicine diagnosis: moderate fatty liver.Tcm diagnosis:
Hypochondriac pain disease, it is dialectical: weakness of the spleen and stomach.It controls in being pacified with invigorating the spleen.Prescription: red yeast rice 15g, red ginseng 12g, hawthorn 20g, seaweed 20g, dent
It is amaranth 20g, muskmelon pedicel 6g, radix bupleuri 12g, dandelion 18g, rhizoma alismatis 12g, oriental wormwood 20g, coptis 12g, radix scutellariae 12g, fructus lycii 20g, thin
Lotus 3g, dried orange peel 12g, prepared RHIZOMA PINELLIZE without adju-vant 9g, Poria cocos 15g.30 doses, daily 1 dose, a point morning and evening warmly takes twice.Advise its dynamic body, regulating spirit and emotion by oneself,
Temperance for food and drink.Burnout symptom out of strength is substantially reduced when further consultation, after monthly outpatient service, added and subtracted with disease, take medicine check liver and gallbladder in more than 3 months altogether
Ultrasound is shown: fatty liver (slight), gallbladder polyps, all diseases disappear substantially.Following the service last time prescription is advised, every two days one.And match
Close " tea of making light of one's life by commiting suicide (wrinkled giant hyssop 6g, eupatorium 6g, lotus leaf 10g) " on behalf of the tea.
Patient it is neat certain, male, 52 years old, first visit on April 27 in 2017.Main suit: in 2 side of body more than 20 years of turgor pain of interruption, companion is aggravated
Abdominal distension 1 week.Existing primary symptom: two side of body turgor pain, with abdominal distension, mouth is glutinous, when have belch, heartburn sour regurgitation, diet is irregular, pharyngeal stifled
Bored, burn feeling, dizzy head cover, spiritlessness and weakness.It defecates dilute, urine tune, pale tongue is dark, yellow and greasy fur, deep thready pulse.Since idiopathy, essence
Mind can, nearly 20 years weights increase 30kg.Outpatient service is looked into: ferritin: 462.70ng/mL.Liver and gallbladder pancreas spleen color ultrasound: fatty liver (weight
Degree).The past high blood pressure medical history, usually preference for fat and sweet food savoury.Tcm diagnosis: hypochondriac pain is sick, accumulates card in turbid poison.Doctor trained in Western medicine diagnosis: weight
Spend fatty liver, 3 grades of high danger of hypertension.It controls to change turbid removing toxic substances.Prescription: red yeast rice 15g, red ginseng 12g, hawthorn 20g, seaweed 20g,
Purslane 20g, muskmelon pedicel 6g, radix bupleuri 12g, dandelion 18g, rhizoma alismatis 12g, oriental wormwood 20g, coptis 12g, radix scutellariae 12g, fructus lycii
20g, peppermint 3g, dried orange peel 12g, prepared RHIZOMA PINELLIZE without adju-vant 9g, Poria cocos 15g.30 doses, daily 1 dose, a point morning and evening warmly takes twice.Advise patient: light drink
Food, avoids pungent greasy, indigestibility product；Appropriate exercise avoids overworked.It is recommended that cardiology department is medical.Outpatient service takes medicine 3 altogether
The moon is added and subtracted with disease, and check liver and gallbladder ultrasound is shown: fatty liver (moderate) advises following the service last time prescription, and every two days one, few edible oil
It is greasy.
Patient Lee, female, 51 years old, the first visit on the 15th of August in 2017.Main suit: interruption right flank secret anguish 3 years.Existing primary symptom: interruption
Right flank secret anguish is uncomfortable, swollen bored with chest gastral cavity, appetite can, body is fat, the big tripe circle of head, burnout out of strength, sticks greasy in mouth, and the red tongue fur of tongue is thick
It is greasy, wiry and rolling pulse.Liver and gallbladder ultrasound is shown: moderate fatty liver, remaining no abnormality seen.Doctor trained in Western medicine diagnosis: fatty liver.Tcm diagnosis: hypochondriac pain disease is distinguished
Card: accumulate in turbid poison, phlegm resistance.Legislation: change turbid removing toxic substances.It is medicinal: red yeast rice 15g, red ginseng 12g, hawthorn 20g, seaweed 20g, dent
It is amaranth 20g, muskmelon pedicel 6g, radix bupleuri 12g, dandelion 18g, rhizoma alismatis 12g, oriental wormwood 20g, coptis 12g, radix scutellariae 12g, fructus lycii 20g, thin
Lotus 3g, dried orange peel 12g, prepared RHIZOMA PINELLIZE without adju-vant 9g, Poria cocos 15g.Its temperance for food and drink, regulating spirit and emotion by oneself, dynamic body are advised in 30 doses of clothes top.Monthly outpatient service,
Medication remaining check liver and gallbladder ultrasound in March is shown altogether: mild fatty liver, all diseases disappear substantially, advise above its following the service 1 month, one dose per day,
Reinforce taking exercise, uncomfortable follow-up.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (6)
1. a kind of Chinese medicine composition for treating non-alcohol fatty liver, which is characterized in that each in the Chinese medicine composition
The parts by weight of raw material are as follows: 13-18 parts of red yeast rice, 10-15 parts of red ginseng, 3-8 parts of muskmelon pedicel, 10-15 parts of radix bupleuri, dandelion 15-20
Part, 10-15 parts of rhizoma alismatis, 15-20 parts of oriental wormwood, 10-15 parts of the coptis, 10-15 parts of radix scutellariae, 15-20 parts of fructus lycii, 10-15 parts of dried orange peel,
5-10 parts and Poria cocos 13-18 parts of prepared RHIZOMA PINELLIZE without adju-vant.
2. a kind of Chinese medicine composition for treating non-alcohol fatty liver according to claim 1, which is characterized in that institute
State the parts by weight of each raw material in Chinese medicine composition are as follows: 15 parts of red yeast rice, 12 parts of red ginseng, 6 parts of muskmelon pedicel, 12 parts of radix bupleuri, Pu Gong
18 parts of English, 12 parts of rhizoma alismatis, 20 parts of oriental wormwood, 12 parts of the coptis, 12 parts of radix scutellariae, 20 parts of fructus lycii, 12 parts of dried orange peel, 9 parts of prepared RHIZOMA PINELLIZE without adju-vant and Fu
15 parts of Siberian cocklebur.
3. a kind of Chinese medicine composition for treating non-alcohol fatty liver according to claim 1, which is characterized in that institute
State the parts by weight of each raw material in Chinese medicine composition are as follows: 13-18 parts of red yeast rice, 10-15 parts of red ginseng, hawthorn 15-20, seaweed 15-
20 parts, 15-20 parts of purslane, 3-8 parts of muskmelon pedicel, 10-15 parts of radix bupleuri, 15-20 parts of dandelion, 10-15 parts of rhizoma alismatis, oriental wormwood 15-
20 parts, 10-15 parts of the coptis, 10-15 parts of radix scutellariae, 15-20 parts of fructus lycii, 1-6 parts of peppermint, 10-15 parts of dried orange peel, 5-10 parts of prepared RHIZOMA PINELLIZE without adju-vant
With 13-18 parts of Poria cocos.
4. a kind of Chinese medicine composition for treating non-alcohol fatty liver according to claim 3, which is characterized in that institute
State the parts by weight of each raw material in Chinese medicine composition are as follows: 15 parts of red yeast rice, 12 parts of red ginseng, 20 parts of hawthorn, 20 parts of seaweed, purslane
20 parts, 6 parts of muskmelon pedicel, 12 parts of radix bupleuri, 18 parts of dandelion, 12 parts of rhizoma alismatis, 20 parts of oriental wormwood, 12 parts of the coptis, 12 parts of radix scutellariae, fructus lycii
20 parts, 3 parts of peppermint, 12 parts of dried orange peel, 9 parts of prepared RHIZOMA PINELLIZE without adju-vant and 15 parts of Poria cocos.
5. a kind of preparation side of the Chinese medicine composition of the described in any item treatment non-alcohol fatty livers of such as claim 1-2
Method, which is characterized in that mainly comprise the steps that
(1) above-mentioned parts by weight red yeast rice, red ginseng, muskmelon pedicel, radix bupleuri, dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae, fructus lycii, old is taken
Skin, prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos；
(2) dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae are put into 30 times of dandelions, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae parts by weight
It is impregnated 1 hour in clear water, half an hour is decocted after boiling；
(3) fructus lycii, dried orange peel, Poria cocos and red ginseng in step (1) are added into the medical fluid of step (2), is decocted 1 hour after boiling；
(4) prepared RHIZOMA PINELLIZE without adju-vant, muskmelon pedicel, rhizoma alismatis, red yeast rice, radix bupleuri in step (1) are added into the medical fluid of step (3), is decocted after boiling
Half an hour；
(5) filtrate is obtained by filtration in the medical fluid of step (4) while hot, the dregs of a decoction add 15 times of water to decoct filtering in 1 hour, merge and obtain twice
Mixed filtrate is obtained to filtrate；
(6) after the mixed filtrate that step (5) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121
DEG C, 20 minutes normal-pressure sterilizations.
6. a kind of preparation side of the Chinese medicine composition of the described in any item treatment non-alcohol fatty livers of such as claim 3-4
Method, which is characterized in that mainly comprise the steps that
(1) above-mentioned parts by weight red yeast rice, red ginseng, hawthorn, seaweed, purslane, muskmelon pedicel, radix bupleuri, dandelion, rhizoma alismatis, oriental wormwood, Huang are taken
Company, radix scutellariae, fructus lycii, peppermint, dried orange peel, prepared RHIZOMA PINELLIZE without adju-vant, Poria cocos；
(2) dandelion, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae are put into 30 times of dandelions, rhizoma alismatis, oriental wormwood, the coptis, radix scutellariae parts by weight
It is impregnated 1 hour in clear water, half an hour is decocted after boiling；
(3) fructus lycii, dried orange peel, Poria cocos and red ginseng in step (1) are added into the medical fluid of step (2), is decocted 1 hour after boiling；
(4) prepared RHIZOMA PINELLIZE without adju-vant in step (1), muskmelon pedicel, hawthorn, seaweed, purslane, rhizoma alismatis, red is added into the medical fluid of step (3)
Bent, radix bupleuri, decocts half an hour after boiling；
(5) peppermint in step (1) is added into the medical fluid of step (4), is decocted 5 minutes after boiling, filtrate, medicine is obtained by filtration while hot
Slag adds 15 times of water to decoct filtering in 1 hour, and merging obtains filtrate twice and obtains mixed filtrate；
(6) after the mixed filtrate that step (5) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C,
20 minutes normal-pressure sterilizations.
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| CN102233119A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药（中国）有限公司 | Traditional Chinese medicine composition for treating fatty liver and preparation method thereof |
| CN104383183A (en) * | 2014-12-10 | 2015-03-04 | 崔合芳 | Medicinal composition for treating non-alcoholic fatty liver |
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Application publication date: 20190507 |