CN109699180B - 细胞共培养芯片及其制备方法 - Google Patents

细胞共培养芯片及其制备方法 Download PDF

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CN109699180B
CN109699180B CN201780043057.1A CN201780043057A CN109699180B CN 109699180 B CN109699180 B CN 109699180B CN 201780043057 A CN201780043057 A CN 201780043057A CN 109699180 B CN109699180 B CN 109699180B
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CN109699180A (zh
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唐纳德·基思·马丁
娜塔丽·皮克莱-德哈汉
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Universite Grenoble Alpes
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201780043057.1A 2016-05-11 2017-05-11 细胞共培养芯片及其制备方法 Active CN109699180B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1654213A FR3051195B1 (fr) 2016-05-11 2016-05-11 Puce de co-culture cellulaire et son procede de fabrication
FR16/54213 2016-05-11
PCT/FR2017/051148 WO2017194894A1 (fr) 2016-05-11 2017-05-11 Puce de co-culture cellulaire et son procede de fabrication

Publications (2)

Publication Number Publication Date
CN109699180A CN109699180A (zh) 2019-04-30
CN109699180B true CN109699180B (zh) 2022-07-26

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Country Status (6)

Country Link
US (1) US11857958B2 (https=)
EP (1) EP3455342B1 (https=)
JP (1) JP6983180B2 (https=)
CN (1) CN109699180B (https=)
FR (1) FR3051195B1 (https=)
WO (1) WO2017194894A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3802848A4 (en) * 2018-05-25 2022-03-09 The University of North Carolina at Chapel Hill FORMATION OF ARRAYS OF PLANAR INTESTINAL CRYPTS WITH A STEM CELL/PROLIFERATIVE CELL COMPARTMENT AND A DIFFERENTIATED CELL ZONE
US12410391B2 (en) 2018-11-16 2025-09-09 The University Of North Carolina At Chapel Hill In vitro cell culture mucus systems
CN113820189A (zh) * 2021-09-10 2021-12-21 深圳市森盈生物科技有限公司 一种用于非妇科的肿瘤筛查的细胞芯片的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004065087A (ja) * 2002-08-06 2004-03-04 National Institute For Materials Science 高密度培養が可能な細胞培養体とその培養モジュール
US7494811B2 (en) * 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
JP2005143343A (ja) * 2003-11-12 2005-06-09 Jgc Corp 細胞培養装置および細胞培養方法
DK2138233T3 (da) * 2008-06-02 2011-01-31 Boehringer Ingelheim Micropart Mikrofluid foliestruktur til dosering af væsker
CN104328050B (zh) * 2008-07-16 2017-12-15 儿童医疗中心有限公司 具有微通道的器官模仿装置及其使用和制造方法
EP2358860A1 (en) 2008-11-21 2011-08-24 Corning Incorporated Spaced projection substrates and devices for cell culture
US8748180B2 (en) * 2009-07-29 2014-06-10 Cornell University Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof
FR2955852B1 (fr) * 2010-01-29 2015-09-18 Corning Inc Dispositif microfluideique en verre, ceramique ou vitroceramique, comprenant une couche intermediaire de traitement comprenant au moins une face ayant une surface structuree ouverte definissant un microcanal ferme par une couche formant feuille en verre, ceramique ou vitroceramique essentiellement plane
JP5700460B2 (ja) 2010-09-10 2015-04-15 株式会社島津製作所 細胞培養デバイス及び細胞培養方法
KR102117921B1 (ko) 2011-02-28 2020-06-03 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 세포 배양 시스템
WO2014008358A1 (en) * 2012-07-05 2014-01-09 Cornell University Porous membrane apparatus, method, and applications
CN104830683B (zh) * 2015-04-30 2017-06-30 大连医科大学附属第二医院 一种用于模拟体内肿瘤细胞及其转移微环境的仿生微流控芯片

Also Published As

Publication number Publication date
FR3051195A1 (fr) 2017-11-17
EP3455342B1 (fr) 2023-10-25
JP6983180B2 (ja) 2021-12-17
WO2017194894A1 (fr) 2017-11-16
US11857958B2 (en) 2024-01-02
JP2019518443A (ja) 2019-07-04
US20190168216A1 (en) 2019-06-06
FR3051195B1 (fr) 2018-05-18
CN109699180A (zh) 2019-04-30
EP3455342A1 (fr) 2019-03-20

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