CN109689016A - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
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- CN109689016A CN109689016A CN201780054135.8A CN201780054135A CN109689016A CN 109689016 A CN109689016 A CN 109689016A CN 201780054135 A CN201780054135 A CN 201780054135A CN 109689016 A CN109689016 A CN 109689016A
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- liquid oral
- oral composition
- menthol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
A kind of liquid oral composition, it is free from the liquid oral composition of p-hydroxybenzoate and (A) menthol containing 0.001~0.15 mass %, it is characterized in that, the composition contains (B) Eugenol and (C) gaultherolin, and (B)/(C) is 0.25~4 by quality ratio, and ((B)+(C))/(A) is 0.65 or more by quality ratio.Inhibit the method for the precipitation of the menthol of the liquid oral composition, the liquid oral composition for being mixed with (A) ingredient to unmixed p-hydroxybenzoate is mixed into (B), (C) ingredient, and making (B)/(C) by quality ratio is 0.25~4, and making ((B)+(C))/(A) by quality ratio is 0.65 or more.
Description
Technical field
The present invention relates to even if carrying out, being inhibited precipitation of cryo-conservation menthol, appearance stability is excellent is free of
The liquid oral composition of p-hydroxybenzoate.
Background technique
In recent years, for composition for oral cavity, improved for the intention to safety etc., increasingly, it is desired that without to hydroxyl
The oral product without p-hydroxybenzoate (paraben free) of yl benzoic acid ester (paraben).
P-hydroxybenzoate, but the known P-hydroxybenzoic acid is widely used as preservative in composition for oral cavity
Ester can affect the stability (precipitation) of menthol mixed usually as freshener in composition for oral cavity, patent text
It offers in 1 (No. 4985905 bulletins of Japanese Patent No.) and proposes there is following technology: by methyl p-hydroxybenzoate and para hydroxybenzene first
Acetoacetic ester and specific nonionic surfactant combinations and be mixed into, in the liquid of the low ethanol composition containing cationic germicide
In composition for oral cavity, the precipitation of the l-menthol after preventing cryo-conservation.
Existing technical literature
Patent document
Patent document 1: No. 4985905 bulletins of Japanese Patent No.
Summary of the invention
Problems to be solved by the invention
However, if not using p-hydroxybenzoate, the stability of menthol is difficult to ensure in terms of product design,
Therefore it is desirable to develop a kind of skill of precipitation for inhibiting the menthol in the liquid oral composition without p-hydroxybenzoate
Art.
Even if the present invention completes in view of the foregoing, and it is an object of the present invention to provide a kind of precipitation for carrying out cryo-conservation menthol
Also be inhibited, bring the liquid oral composition without p-hydroxybenzoate of excellent appearance stability.
To the means solved the problems, such as
The present inventor has made intensive studies in order to achieve the above objectives, as a result, it has been found that: Xiang Buhan p-hydroxybenzoate
And in containing menthol liquid oral composition, at a specific ratio by Eugenol and gaultherolin combined hybrid
When, even if after cryo-conservation, menthol also stabilizes and suppressed, appearance stability raising is precipitated.That is, discovery: according to this hair
It is bright, by be free of p-hydroxybenzoate and (A) menthol containing 0.001~0.15 mass % liquid oral combine
In object, mixing (B) Eugenol and (C) gaultherolin, by quality ratio, (B)/(C) are 0.25~4, ((B)+(C))/(A)
It is by quality ratio 0.65 or more, it is possible thereby to provide a kind of liquid port for being free of p-hydroxybenzoate (paraben free)
Chamber composition brings excellent appearance stablity even if the composition, after cryo-conservation, the precipitation of menthol is also inhibited
Property, furthermore peculiar smell is suppressed, and use feeling is also good, and has thus completed the present invention.
According to the present invention, if by (B) fourth in being free of the liquid oral compositions such as the collutory of p-hydroxybenzoate
Sesame oil phenol and (C) gaultherolin combine, then the mass ratio of (B)/(C) is in particular range, and the matter of ((B)+(C))/(A)
Measure ratio more than particular value, as (A) menthol stabilization agent and play after cryo-conservation inhibit menthol precipitation work
With thus bringing the excellent appearance stability for also not crystallizing precipitation after saving 1 month at -5 DEG C as caused by menthol.This
In the case of kind, although well known Eugenol, gaultherolin respectively have unique peculiar smell as oral cavity fragrance,
If (B), (C) ingredient are applied in combination in appropriate proportions, inhibit the precipitation of menthol in the case where peculiar smell will not be embodied, mention
Apperance stability brings the especially obvious action effect that cannot reach when only adding unsuitable oral cavity fragrance.
In the present invention, even if the liquid oral composition without p-hydroxybenzoate is the non-alcohol or low of low irritant
Alcohol composition, or it is the reduction of the composition of the additive amount of surfactant, the precipitation of methanol is also inhibited, and appearance stability is excellent
It is different, cationic fungicide can be added furthermore satisfactorily to show the sterilizing power to oral cavity bacterium, can also enabled
People satisfactorily assigns the refrigerant sense obtained by menthol.
Therefore, the present invention provides following liquid oral compositions and inhibits the menthol in liquid oral composition
Precipitation method.
[1]
A kind of liquid oral composition is free from p-hydroxybenzoate and (A) containing 0.001~0.15 mass %
The liquid oral composition of menthol, which is characterized in that the composition contains (B) Eugenol and (C) gaultherolin, and
And it is 0.65 or more that (B)/(C) is 0.25~4, ((B)+(C))/(A) by quality ratio by quality ratio.
[2]
The liquid oral composition according to [1], wherein the content of (B) Eugenol is 0.00013~0.2 matter
% is measured, the content of (C) gaultherolin is 0.00013~0.2 mass %.
[3]
According to liquid oral composition described in [1] or [2], wherein (B) Eugenol and (C) gaultherolin
Content adds up to 0.00065~0.4 mass %.
[4]
The liquid oral composition according to any one of [1]~[3], wherein the composition is also according to need
To contain (D) ethyl alcohol, content is 0~15 mass %.
[5]
The liquid oral composition according to any one of [1]~[4], wherein the composition also contains 0.1
(E) nonionic surfactant of~0.5 mass %, (E) nonionic surfactant are selected from ethylene oxide
The Crodaret and carbochain that average addition molal quantity is 40~100 moles are a length of 16~18, ethylene oxide
It is one kind or two or more in the polyoxyethylene alkyl ether that average addition molal quantity is 10~50 moles.
[6]
The liquid oral composition according to any one of [1]~[5], wherein the composition also contains
(F) cationic fungicide of 0.01~0.1 mass %.
[7]
A method of inhibit menthol in the liquid oral composition to be precipitated, which is characterized in that without to hydroxyl
Yl benzoic acid ester and containing 0.001~0.15 mass % (A) menthol liquid oral composition in add (B) Eugenol
(C) gaultherolin makes (B)/(C) by quality ratio for 0.25~4, and makes ((B)+(C))/(A) be by quality ratio
0.65 or more.
Invention effect
According to the present invention it is possible to provide it is a kind of be inhibited the precipitation of menthol even if after cryo-conservation, appearance it is steady
The qualitative excellent liquid oral composition without p-hydroxybenzoate.In addition, according to the present invention it is possible to providing inhibition not
The method of the precipitation of menthol in liquid oral composition containing p-hydroxybenzoate.
Specific embodiment
The present invention is described in detail further below, liquid oral composition of the invention is free from the nothing of p-hydroxybenzoate
The liquid preparation of p-hydroxybenzoate contains (B) Eugenol and (C) water while containing (A) menthol with special ratios
Poplar acid methyl esters.
In the present invention, as p-hydroxybenzoate, methyl p-hydroxybenzoate, P-hydroxybenzoic acid second are specifically enumerated
The alkyl parabens such as ester, butyl p-hydroxybenzoate.These substances are not mixed into composition of the invention.
(A) menthol is to confer to the ingredient of refrigerant sense, and l-menthol can be used.
(A) content of menthol is 0.001~0.15% (quality %, same as below) entirely formed, preferably 0.005
~0.1%.Content is more, and refrigerant sense more enhances, if but more than 0.15%, the precipitation of menthol cannot inhibit, and appearance is steady
Qualitative decline.In addition, stimulation is too strong, use feeling can deteriorate.
In the present invention, by the way that fragrance component (B) Eugenol and (C) gaultherolin are applied in combination, (B), (C) ingredient
Paralled system play the role of inhibiting as the stabilization agent of menthol its to be precipitated, as a result, after cryo-conservation, appearance stability
Also excellent, clear and bright property can also be maintained, the peculiar smell as caused by the two furthermore can also be inhibited.If lacking (B) or (C) ingredient,
Peculiar smell cannot inhibit, and smell is deteriorated.
(B) content of Eugenol preferably entirely form 0.00013~0.2%, more preferably 0.003~0.1%.Contain
Amount is more, inhibits the effect of the precipitation of menthol more to increase, sufficient appearance stability is obtained at 0.00013% or more.It is right
For inhibiting peculiar smell, the content of (B) Eugenol is that 0.2% the following are be suitable for.When more than 0.2%, even if with (C) salicylic acid
Methyl esters combination, there is also peculiar smell is experienced, peculiar smell cannot sufficiently be inhibited the phenomenon that by existing.
(C) content of gaultherolin preferably entirely form 0.00013~0.2%, more preferably 0.003~0.1%.
Content is more, and the effect of the precipitation of menthol is inhibited more to increase, and sufficient appearance stability is obtained at 0.00013% or more.
For inhibiting peculiar smell, the content of (B) Eugenol is that 0.2% the following are be suitable for.When more than 0.2%, even if with (B) cloves
Oily phenol combination, there is also peculiar smell is experienced, peculiar smell cannot sufficiently be inhibited the phenomenon that by existing.
(B) total content of Eugenol and (C) gaultherolin can be set as entirely form 0.00026~0.4%,
But particularly preferred 0.00065~0.4 mass %, more preferably 0.006~0.2 mass %.When in the range, the analysis of menthol
It is sufficiently suppressed out, appearance stability increases, and peculiar smell is also sufficiently suppressed.When less than 0.00026%, exists and inhibit menthol
The effect of precipitation reduces the situation of appearance stability difference, when being more than 0.4%, there are the feelings for generating peculiar smell and use feeling being caused to be deteriorated
Condition.
In the present invention, (B)/(C) of the containing ratio of display (B) Eugenol and (C) gaultherolin, by quality ratio
It is 0.25~4, preferably 0.26~3.8.(B) when/(C) is outside the range, the peculiar smell enhancing from (B), (C) ingredient, no
It can inhibit peculiar smell, furthermore there is the case where fragrance also enhances, use feeling is deteriorated.
In the present invention, the containing ratio of (B) Eugenol and (C) gaultherolin relative to (A) menthol is shown
((B)+(C))/(A), is by quality ratio 0.65 or more, preferably 0.7 or more.If menthol is precipitated less than 0.65
Less than inhibition, appearance stability is poor.In addition, the viewpoint based on refrigerant sense, the upper limit of the mass ratio of ((B)+(C))/(A) are preferably
3 hereinafter, more preferably 2 hereinafter, further preferably 1.5 or less.
Liquid oral composition of the invention is also possible to forming without alcohol without (D) ethyl alcohol (content 0%), if but into
One step adds (D) ethyl alcohol, then inhibits the effect of the precipitation of menthol to increase, appearance stability more improves.
(D) content of ethyl alcohol preferably entirely form 0~15%, in the case where addition, preferably 1~15%, especially
It is 2~10%, is further preferred that 4~8%.Content is more, and appearance stability more improves, but for inhibiting stimulation, and 15%
Below conveniently.In addition, preferably including the total amount of the ethyl alcohol in the composition of ethyl alcohol in above range when containing ethyl alcohol in fragrance
It is interior.
Furthermore (E) nonionic surfactant is added preferably as surfactant, adds (E) nonionic table
When the activating agent of face, fragrance component sufficiently soluble inhibits the effect of the precipitation of menthol to increase, and appearance stability more improves.
Specifically, solubilized, use feeling the viewpoint based on fragrance, the average addition molal quantity (E.O.) for being preferably selected from ethylene oxide are
40~100 moles of Crodaret and carbochain be a length of 16~18, ethylene oxide average addition molal quantity is
It is one kind or two or more in 10~50 moles of polyoxyethylene alkyl ether, in particular, based on the viewpoint for inhibiting peculiar smell, more preferably
It E.O. is 60~100 moles of Crodaret.
(E) content of nonionic surfactant is 0.5% entirely formed hereinafter, particularly preferred 0.1~0.5%.
When content is 0.1% or more, fragrance sufficiently soluble, if but adding excessive, the anxiety of sterilizing power decline when having addition fungicide.
Liquid oral composition of the invention can further contain (F) cationic fungicide.If addition cation
Property fungicide, then other than excellent appearance stability, free from extraneous odour, also effective earth's surface, which reveals, imitates the oral cavity sterilization of bacterium
Fruit.
As (F) cationic fungicide, such as enumerate the quaternary ammonium salts such as cetylpyridinium chloride, benzalkonium chloride；Hydrochloric acid
The chlorhexidine salts such as chlorohexidene, chlorhexidine gluconate can be used one kind or two or more in these substances.Wherein, based on effect
Fruit embodies the viewpoint of property, and as the cetylpyridinium chloride of quaternary ammonium salt, benzalkonium chloride, especially cetylpyridinium chloride is more
It is suitable for.
Add (F) cationic fungicide when, content preferably entirely form 0.01~0.1%, more preferably 0.02
~0.05%.Content is more, improves to the oral cavity bactericidal effect of bacterium, if but excessive, the case where there are use feeling reductions.
Liquid oral composition of the invention can be used as gargling for general collutory, concentrated type collutory etc.
Agent；Freshener etc. is prepared, is applicable in mouthful.In addition, can also mix other well known ingredient except mentioned component according to dosage form.
Such as it can be added in collutory anti-other than wetting agent, thickener, surfactant, pH adjusting agent, p-hydroxybenzoate
Rotten agent, fragrance, effective component, sweetener, colouring matter in addition to (A), (B) and (C) ingredient etc..
As wetting agent, enumerate glycerol, D-sorbite, propylene glycol, ethylene glycol, polyethylene glycol, xylitol, maltitol,
Lactitol etc..
As thickener, xanthan gum, carragheen, hydroxymethyl cellulose, mosanom, polyvinyl alcohol etc. are enumerated.
Other surface-actives can also be enumerated other than (E) nonionic surfactant as surfactant
Agent, such as sodium tetradecyl sulfate, N- Hamposyl L salt, lauroyl methyl taurine, acyl amino hydrochlorate, dodecyl
The anionic surfactants such as benzene sulfonic acid sodium salt, alpha-sulfo-fatty acid alkyl ester sodium, alkyl phosphate salt；Alkyl dimethyl amino
The acetic acid betaine type surface amophoteric surface actives such as acetic acid glycine betaine, fatty acid amide propyl dimethylamino acetic acid glycine betaine
Agent；The imidazoline types amphoteric surfactantes, N- fatty acid acyl such as N- fatty acid acyl-N- carboxymethyl-N-hydroxyethyl-ethylenediamine salt
Amino acid type surfactants such as base-L- alginate esters salt etc., can add one kind or two or more in these substances.These surfaces
The additive amount of activating agent is preferably 0~5%, and more preferably 0.01% or more, further preferably 0.01~1%.
As pH adjusting agent, phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbon are enumerated
Sylvite, sodium salt, the ammonium salt of acid and these substances；Ribonucleic acid or its salt；Sodium hydroxide etc. can be used one kind or two or more.
Substance obtained by particularly preferably combining phosphoric acid, citric acid with their sodium salt.
PH at 25 DEG C is preferably adjusted to 5.5~7.5 by liquid oral composition of the invention, the pH neighbouring as this
Regulator, can by the two of sodium dihydrogen phosphate and disodium-hydrogen or by the combination of the two of citric acid and sodium citrate and
It uses.
As preservative, in the range of not interfering effect of the invention, such as can be by sodium benzoate, salt dialkylaminobenzoic acid two
Aminoethylglycine, potassium sorbate etc..
As fragrance, spearmint oil, eucalyptus oil, wintergreen, caryophyllus oil, hundred inner careless oil, sage oil, red bean can be used
The natural essential oils such as cool oil, rosemary oil, marjoram oil, lemon oil, mace oil, lavender oil, Spilanthes oleracea oil；And l- Sheep's-parsley
Ketone, 1,8- Cineole, thymol, linalool, limonene, menthones, menthyl acetate, citral, camphor, borneol, firpene, thousand days
Fragrance component contained in the above-mentioned natural essential oil of chrysanthemum amide (spilanthol) etc.；And ethyl acetate, ethyl butyrate, acetic acid
Isopentyl ester, hexanal, hexenoic aldehyde (hexenal), methyl anthranilate, methyl phenyl ethyl glycidate, benzaldehyde, perfume (or spice)
Oxalaldehyde, ethyl vanillin, furanone, maltol, ethylmaltol, gamma/delta-decalactone, gamma/delta-undecalactone, N- ethyl-right
The fragrance components such as terpane -3- carboxylic acid amides, menthyl lactate, ethylene glycol-l-menthol carbonic ester；Further by several fragrance at
Point and natural essential oil be composed apple flavor, banana flavor, strawberry flavor, blueberry flavor, muskmelon flavor, peach flavor,
Pineapple flavor, grape flavor, muscat flavor, grape wine taste, cherry flavor, winter squash flavor, coffee flavor, brandy wind
Taste, yoghourt-flavored etc. are concocted one kind or two or more in flavor.Combined amount can be 0.00001~3%, can not interfere this
It is used in the range of The effect of invention.
In addition, in fragrance contain (A), (B) or (C) ingredient when, can use within the above range (A), (B) or (C) at
The content divided.
Other effective components, such as ammonia can also be added other than (F) cationic fungicide as effective component
The anti-inflammatory agents such as first naphthenic acid, ε-aminocaproic acid；Dextranase, protease, becomes the enzymes such as dextranase, lysozyme, catabolic enzyme at amylase；
The fluorides such as sodium fluoride, sodium monofluorophosphate, stannous fluoride；Allantoin chloro hydroxy Al, allantoin, azulene, chlorinated lysozyme,
The vitamins such as ascorbic acid；Beta-cholestanol；Glycyrrhizin salt；Enoxolone class；Hydrocholesterol；Chlorophyll；Ye Lv
Plain copper sodium；The plant extracts such as thyme, radix scutellariae, cloves, witch hazel；Copper gluconate；Sea dog peptide (carropeptide)；Poly- phosphorus
Sour sodium；Water-soluble inorganic phosphate cpd；Polyethylene glycol；Polyvinylpyrrolidone；Lauroyl sodium salicylate；Dental calculus prevents
Agent；Tartar preventing agent；Sodium nitrate；Aluctyl etc..In addition, the combined amount of these effective components is not interfere effect of the invention
In the range of effective quantity.
As sweetener, saccharin sodium, Stevioside etc. are enumerated.
As colorant, highly-safe water-soluble such as blue 1, green 3, yellow 4, No. 105 red can be added
Property pigment.
Embodiment
Hereinafter, showing experimental example, embodiment and comparative example to illustrate the present invention, but the present invention is not by following realities
Example is applied to be limited.In addition, unless otherwise specified, % indicates quality % in following examples.
[experimental example 1]
By conventional method with the liquid oral composition (collutory) formed shown in tabulation 1~3, by these compositions
Used as sample, with following methods evaluate cryo-conservation after appearance stability, have free from extraneous odour.Result is shown in table 1 together
~3.
<evaluation method of appearance stability>
450mL sample collutory is filled in PET (polyethylene terephthalate) container of the amount of filling 500mL ,-
It is saved in 5 DEG C of thermostats 1 month, later, according to following benchmark visual valuation appearance stabilities.The sample of zero or ◎ is considered as thin
The precipitation of lotus alcohol is suppressed, appearance stability is qualified.
The evaluation criteria of appearance stability；
◎: not having difference with initial stage product, can't see acicular crystal precipitation.
Zero: it can be seen that the dregs of denier.
△: it can be seen that micro crystallization is precipitated.
×: it can be seen that acicular crystal is precipitated.
<evaluation method for having free from extraneous odour>
The collutory of sample containing 10mL is commented after 30 seconds there is free from extraneous odour or less to state 3 stages after gargling in mouth
Valence.The average mark of 10 people is calculated, the above are qualifications with 2.0 points.
There is the evaluation criteria of free from extraneous odour；
3 points: not smelling a strange smell
2 points: slightly smelling a strange smell
1 point: smelling a strange smell
[table 1]
* fragrance does not include menthol, Eugenol and gaultherolin (same as below).
[table 2]
[table 3]
[experimental example 2]
The liquid oral composition (collutory) of No.1~11 shown in table 1 is used as sample, is evaluated with following methods
Bactericidal effect, refrigerant sense.Table 4 is shown in using result as No.2-1~2-11.
<to the evaluation method of the bactericidal effect of oral cavity bacterium>
The simple Counting alive microbial kit of the Streptococcus mutans in saliva has been used in Counting alive microbial test
Dentocult-SM (manufacture of Orion Diagnostica company, Finland).It is commented previously according to the application method of Dentocult-SM
Bacterium number in valence saliva, according to following evaluation criteria, using 10 2 points or more of people as object.
Equally is gargled using Dentocult-SM measurement collutory of sample containing 10mL in mouth, is small by 3 within 30 seconds
When after saliva in Streptococcus mutans number, evaluate bactericidal effect according to evaluation criteria shown in following.Calculating 10 is averaged
Point.Score is smaller, and bactericidal effect is higher, below is chosen as qualification for 1.5 points.
The evaluation criteria of bactericidal effect；
3 points: Streptococcus mutans number is 106More than
2 points: Streptococcus mutans number is 105Above and less than 106
1 point: Streptococcus mutans number is less than 105
<evaluation method of refrigerant sense>
The collutory of sample containing 10mL is gargled for 30 seconds in mouth, is commented with following 3 stages the refrigerant sense after gargling
Valence refrigerant sense.Calculate 10 average marks.Qualification is chosen as by 2.0 points or more.
The evaluation criteria of refrigerant sense after gargling；
3 points: confirmation has refrigerant sense
2 points: confirmation slightly refrigerant sense
1 point: not can confirm that refrigerant sense
[table 4]
Claims (7)
1. a kind of liquid oral composition, is free from p-hydroxybenzoate and (A) containing 0.001~0.15 mass % is thin
The liquid oral composition of lotus alcohol, which is characterized in that the composition contains (B) Eugenol and (C) gaultherolin, and
(B)/(C) is 0.25~4 by quality ratio, and ((B)+(C))/(A) is 0.65 or more by quality ratio.
2. liquid oral composition according to claim 1, wherein the content of (B) Eugenol be 0.00013~
0.2 mass %, the content of (C) gaultherolin are 0.00013~0.2 mass %.
3. according to liquid oral composition of any of claims 1 or 2, wherein (B) Eugenol and (C) gaultherolin
Content adds up to 0.00065~0.4 mass %.
4. liquid oral composition described in any one of claim 1 to 3, wherein the composition is also according to need
To contain (D) ethyl alcohol, content is 0~15 mass %.
5. liquid oral composition according to any one of claims 1 to 4, wherein the composition also contains 0.1
(E) nonionic surfactant of~0.5 mass %, (E) nonionic surfactant are selected from ethylene oxide
The Crodaret and carbochain that average addition molal quantity is 40~100 moles are a length of 16~18, ethylene oxide
It is one kind or two or more in the polyoxyethylene alkyl ether that average addition molal quantity is 10~50 moles.
6. liquid oral composition according to any one of claims 1 to 5, wherein the composition also contains
(F) cationic fungicide of 0.01~0.1 mass %.
7. a kind of inhibit the method that menthol is precipitated in the liquid oral composition, which is characterized in that without to hydroxyl
Benzoic ether and containing 0.001~0.15 mass % (A) menthol liquid oral composition in addition (B) Eugenol and
(C) gaultherolin, making (B)/(C) by quality ratio is 0.25~4, and making ((B)+(C))/(A) by quality ratio is 0.65
More than.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016172873A JP6614071B2 (en) | 2016-09-05 | 2016-09-05 | Liquid oral composition |
| JP2016-172873 | 2016-09-05 | ||
| PCT/JP2017/030278 WO2018043275A1 (en) | 2016-09-05 | 2017-08-24 | Liquid oral-cavity composition |
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| CN109689016A true CN109689016A (en) | 2019-04-26 |
| CN109689016B CN109689016B (en) | 2022-01-14 |
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| JP (1) | JP6614071B2 (en) |
| KR (1) | KR102270933B1 (en) |
| CN (1) | CN109689016B (en) |
| WO (1) | WO2018043275A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007031394A (en) * | 2005-07-29 | 2007-02-08 | Lion Corp | Liquid composition for oral cavity and method for preventing 1-menthol deposition |
| JP2008094772A (en) * | 2006-10-13 | 2008-04-24 | Lion Corp | Liquid composition for oral cavity |
| CN101573097A (en) * | 2006-07-07 | 2009-11-04 | 宝洁公司 | Flavors for oral compositions |
| JP2011073979A (en) * | 2009-09-29 | 2011-04-14 | Sunstar Inc | Oral composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272513A (en) * | 1980-01-31 | 1981-06-09 | Colgate-Palmolive Company | Stabilized oral composition |
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2017
- 2017-08-24 WO PCT/JP2017/030278 patent/WO2018043275A1/en active Application Filing
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007031394A (en) * | 2005-07-29 | 2007-02-08 | Lion Corp | Liquid composition for oral cavity and method for preventing 1-menthol deposition |
| CN101573097A (en) * | 2006-07-07 | 2009-11-04 | 宝洁公司 | Flavors for oral compositions |
| JP2008094772A (en) * | 2006-10-13 | 2008-04-24 | Lion Corp | Liquid composition for oral cavity |
| JP2011073979A (en) * | 2009-09-29 | 2011-04-14 | Sunstar Inc | Oral composition |
Non-Patent Citations (1)
| Title |
|---|
| 于淞等: "《皮肤医学美容学》", 31 October 1997 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6614071B2 (en) | 2019-12-04 |
| CN109689016B (en) | 2022-01-14 |
| KR102270933B1 (en) | 2021-06-30 |
| WO2018043275A1 (en) | 2018-03-08 |
| KR20190046774A (en) | 2019-05-07 |
| JP2018039739A (en) | 2018-03-15 |
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