CN109620778A - A kind of Essence and the preparation method and application thereof for treating diaper rash - Google Patents
A kind of Essence and the preparation method and application thereof for treating diaper rash Download PDFInfo
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- CN109620778A CN109620778A CN201910114339.7A CN201910114339A CN109620778A CN 109620778 A CN109620778 A CN 109620778A CN 201910114339 A CN201910114339 A CN 201910114339A CN 109620778 A CN109620778 A CN 109620778A
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- 206010012444 Dermatitis diaper Diseases 0.000 title claims abstract description 34
- 208000003105 Diaper Rash Diseases 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 91
- 240000000774 Cunila origanoides Species 0.000 claims abstract description 41
- 235000018274 Cunila origanoides Nutrition 0.000 claims abstract description 41
- 235000014866 Dictamnus albus Nutrition 0.000 claims abstract description 41
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims abstract description 29
- 229960004191 artemisinin Drugs 0.000 claims abstract description 29
- 229930101531 artemisinin Natural products 0.000 claims abstract description 29
- 241001645380 Bassia scoparia Species 0.000 claims abstract description 20
- 241001529847 Collinsonia Species 0.000 claims abstract description 20
- 235000021028 berry Nutrition 0.000 claims abstract description 19
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000011732 tocopherol Substances 0.000 claims abstract description 14
- 229960001295 tocopherol Drugs 0.000 claims abstract description 14
- 229930003799 tocopherol Natural products 0.000 claims abstract description 14
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 14
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 14
- 241001252601 Blumea Species 0.000 claims abstract description 13
- 239000001198 melaleuca alternifolia leaf oil Substances 0.000 claims abstract description 13
- 239000007921 spray Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims description 19
- 239000003921 oil Substances 0.000 claims description 12
- 235000001405 Artemisia annua Nutrition 0.000 claims description 11
- 240000000011 Artemisia annua Species 0.000 claims description 11
- 230000010355 oscillation Effects 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 abstract description 3
- 239000008280 blood Substances 0.000 abstract description 3
- 210000004369 blood Anatomy 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 230000017423 tissue regeneration Effects 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 230000001835 salubrious effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 14
- 230000000694 effects Effects 0.000 description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- AVFIYMSJDDGDBQ-UHFFFAOYSA-N Parthenium Chemical compound C1C=C(CCC(C)=O)C(C)CC2OC(=O)C(=C)C21 AVFIYMSJDDGDBQ-UHFFFAOYSA-N 0.000 description 2
- 241001495454 Parthenium Species 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 210000001217 buttock Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 235000010894 Artemisia argyi Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000526900 Camellia oleifera Species 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 244000030166 artemisia Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- -1 compound polyphenol Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to baby care product technical fields, more particularly to a kind of Essence and the preparation method and application thereof for treating diaper rash, Essence includes the component of following mass percent: Artemisinin 3~10%, shaggy-fruited dittany root bark extract 3~10%, summer cypress berry extract 3~10%, collinsonia canadensis extract 3~10%, Blumea oil 3~10%, tocopherol 0.5~0.8%, surplus is Melaleuca alternifolia leaf oil, the Essence can be mixed to prepare spray use with water, or be added to smear to smear in emulsifiable paste and use.Essence of the invention has the function of clearing damp sterilization, anti-inflammatory anti-itch, blood activating and promoting tissue regeneration, dispelling wind and removing obstruction in the meridians, and the tender skin of children for takeing good care of baby comprehensively keeps small hip salubrious, tender white from the infringement of diaper rash, is full of elastic force.
Description
Technical field
The present invention relates to baby care product technical fields more particularly to a kind of for treating the Essence and its system of diaper rash
Preparation Method and application.
Background technique
Diaper rash is commonly called as red hip (i.e. red stern, paediatrics name of disease), is a kind of dermatitis venereal disease occurred wrapping up in diaper position
Become, also referred to as the red stern of baby.Because the skin of baby is extremely delicate, if long period of soaking is in urine or because diaper is airtight and damp
If wet, buttocks, which often will appear red small measles or skin, becomes relatively rough.If baby wraps up in wet diaper or dirty for a long time
Diaper, skin will be stimulated, and form diaper rash.Diaper rash shows as the rubefaction of buttocks and diaper contact area, hair
It is swollen, in addition occur festering, ulcer and infection, slightly slight external force or friction will cause to damage.Diaper rash is also known as " diaper skin
Inflammation ", " ammonia dermatitis ", are a kind of non-infectious scytitis, " contact dermatitis ", " physics are classified as in clinical medicine
Property dermatitis ", " allergy dermatitis " (W allergic reaction type) scope.
About the etiology and pathology of diaper rash, medical field there is no clearly come to a conclusion so far, it is considered that be following combined factors hair
Wave the result of effect: (1) local humidity is too big: especially the lasting permeability of paper diaper surface material is poor and the amount of bleeding back compared with
In the case where big, urine is easily stayed in surface layer storage, causes skin overly hydrated, and stratum corneum barrier function is reduced, shown as to bad
The sensibility of stimulation enhances；(2) part is breathed freely bad, further limits the volatilization of moisture, and can promote allergy indirectly
Generation；(3) allergic effect primary stimuli, the allergen include: 1. free ammonia: the effect of urea in urine in bacteriaria solution enzyme
Under, it is decomposed into ammonium hydroxide, increases the pH value of urine, when pH is greater than 7.0, easily releases free property ammonia；2. fecal enzymes:
In recent years medical field current research the result shows that, each albuminoid that (especially dyspeptic infant faeces) contain in excrement is split
Enzyme and fat splitting enzyme are solved, is the important allergen for causing diaper dermatitis, it is notable that in partial closure, high humility, outstanding
In the environment of it is high ph-values, the activity of fecal enzymes is remarkably reinforced；3. microorganism: bacterium or fungi and its metabolite.
Chinese patent (CN103690664A) discloses a kind of external application Chinese medicine for treating newborn diapers rash, has heat-clearing dry
It is wet, the effect of wind-dispelling removing toxic substances, but medication is not mild enough, and for infant's use, there is also irritations；It must be outer every time when use
It applies 10 minutes or so, since infant's fitness is low, the difficulty that operates is larger；It is possible that meeting scar, there are certain
Limitation.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of for treating the Essence of diaper rash, there is clearing damp sterilization, disappear
Scorching antipruritic, blood activating and promoting tissue regeneration, dispelling wind and removing obstruction in the meridians effect, the tender skin of children for takeing good care of baby comprehensively are kept small from the infringement of diaper rash
Hip are salubrious, tender white, are full of elastic force.
The present invention solves above-mentioned technical problem by following technological means:
It is a kind of for treating the Essence of diaper rash, including Artemisinin, shaggy-fruited dittany root bark extract, summer cypress fruit are extracted
Object, collinsonia canadensis extract, Blumea oil, Melaleuca alternifolia leaf oil, tocopherol.
Further, the Essence includes the component of following mass percent: Artemisinin 3~10%, shaggy-fruited dittany root skin
Extract 3~10%, summer cypress berry extract 3~10%, collinsonia canadensis extract 3~10%, Blumea oil 3~10%, tocopherol
0.5~0.8%, surplus is Melaleuca alternifolia leaf oil.
Further, the matter of the Artemisinin, shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract
Amount is than being 1:1:1:1.
Further, the Artemisinin, shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract are adopted
Use supercritical CO2Extraction extracts to obtain.
Further, the Essence includes the component of following mass percent: Artemisinin 5%, shaggy-fruited dittany root skin are extracted
Object 5%, summer cypress berry extract 5%, collinsonia canadensis extract 5%, Blumea oil 5%, tocopherol 0.6%, surplus are that alternate leaf is white
Thousand layers of leaf oil.
Further, the Artemisinin prepare it is as follows: dry sweet wormwood is crushed to 200~300 meshes, Yu Wendu
46~48 DEG C, 4~6MPa of pressure, 3~4MPa of separating pressure, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtains
Extract liquor, that is, Artemisinin.
Further, the shaggy-fruited dittany root bark extract prepare it is as follows: dry shaggy-fruited dittany root skin is pulverized to 1200 mesh
Sieve, 48~52 DEG C of Yu Wendu, 6~8MPa of pressure, separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction
It takes, obtained extract liquor i.e. shaggy-fruited dittany root bark extract.
In addition, the invention also discloses above-mentioned for treating the preparation method of the Essence of diaper rash, the preparation method
It is as follows: take Artemisinin, shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract to carry out microwave oscillation mixing,
Blumea oil, Melaleuca alternifolia leaf oil and tocopherol is then added to stir and evenly mix to get Essence is arrived.
Further, the microwave oscillation is specially in 30~35 DEG C of temperature, power 300W, the oscillation of frequency 500MHz condition
5min。
In addition, the Essence can be with water the invention also discloses the application of the above-mentioned Essence for being used to treat diaper rash
It is mixed to prepare spray use, or is added to smear to smear in emulsifiable paste and use.
Further, content of the Essence in spray or smearing emulsifiable paste is 3~8%.
Present invention sweet wormwood, cortex dictamni, summer cypress fruit, purple perilla, folium artemisiae argyi, tea oil plant polyphenol active ingredient, cooperation dimension
Raw element E is made the compound polyphenol of natural activity and dispels diaper rash essence, there is clearing damp sterilization, anti-inflammatory anti-itch, blood activating and promoting tissue regeneration, wind-dispelling to lead to
The effect of network.Essence of the invention can be safely and effectively configured to without any chemical antibacterial agent or antibiotic with refined plant oil
Finish is configured to emulsion through emulsification, is the preferred raw materials of infant's hip pad product.
Specific embodiment
Below with reference to specific embodiment, the present invention is described in detail:
Of the invention a kind of for treating the Essence of diaper rash, the component including following mass percent: sweet wormwood extracts
Object 3~10%, shaggy-fruited dittany root bark extract 3~10%, summer cypress berry extract 3~10%, collinsonia canadensis extract 3~10%, Chinese mugwort
Leaf oil 3~10%, tocopherol 0.5~0.8%, surplus are Melaleuca alternifolia leaf oil.Wherein, Artemisinin, shaggy-fruited dittany root skin
Extract, summer cypress berry extract, collinsonia canadensis extract mass ratio be 1:1:1:1.And the present invention use Artemisinin,
Shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract are all made of supercritical CO2Extraction extracts to obtain.
Specifically, Artemisinin prepare it is as follows: dry sweet wormwood is crushed to 200~300 meshes, Yu Wendu 46~
48 DEG C, 4~6MPa of pressure, 3~4MPa of separating pressure, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extraction
Take liquid i.e. Artemisinin.
Preparing for shaggy-fruited dittany root bark extract is as follows: dry shaggy-fruited dittany root skin is pulverized to 1200 meshes, Yu Wendu 48
~52 DEG C, 6~8MPa of pressure, separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extraction
Liquid, that is, shaggy-fruited dittany root bark extract.
Essence for treating diaper rash of the invention can be mixed to prepare spray use with water, or be added and smear cream
It smears and uses in cream, and content of the Essence in spray or smearing emulsifiable paste is 3~8%.
Embodiment one
Preparing for the Artemisinin of the present embodiment is as follows: dry sweet wormwood is crushed to 200 meshes, Yu Wendu 46~48
DEG C, pressure 5MPa, separating pressure 3.5MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor is i.e.
Artemisinin.
Preparing for the shaggy-fruited dittany root bark extract of the present embodiment is as follows: dry shaggy-fruited dittany root skin is pulverized to 1200 mesh
Sieve, 48~52 DEG C of Yu Wendu, pressure 7MPa, separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtains
The extract liquor arrived i.e. shaggy-fruited dittany root bark extract.
The Essence for treating diaper rash of the present embodiment includes the component of following mass percent: Artemisinin
5%, shaggy-fruited dittany root bark extract 5%, summer cypress berry extract 5%, collinsonia canadensis extract 5%, Blumea oil 5%, tocopherol
0.6%, surplus is Melaleuca alternifolia leaf oil.
Embodiment two
Preparing for the Artemisinin of the present embodiment is as follows: dry sweet wormwood is crushed to 300 meshes, Yu Wendu 46~48
DEG C, pressure 4MPa, separating pressure 3MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor are i.e. green
Parthenium extract.
Preparing for the shaggy-fruited dittany root bark extract of the present embodiment is as follows: dry shaggy-fruited dittany root skin is pulverized to 1200 mesh
Sieve, 48~52 DEG C of Yu Wendu, pressure 6MPa, separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtains
The extract liquor arrived i.e. shaggy-fruited dittany root bark extract.
The Essence for treating diaper rash of the present embodiment includes the component of following mass percent: Artemisinin
3%, shaggy-fruited dittany root bark extract 3%, summer cypress berry extract 3%, collinsonia canadensis extract 3%, Blumea oil 3%, tocopherol
0.5%, surplus is Melaleuca alternifolia leaf oil.
Embodiment three
Preparing for the Artemisinin of the present embodiment is as follows: dry sweet wormwood is crushed to 260 meshes, Yu Wendu 46~48
DEG C, pressure 6MPa, separating pressure 4MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor are i.e. green
Parthenium extract.
Preparing for the shaggy-fruited dittany root bark extract of the present embodiment is as follows: dry shaggy-fruited dittany root skin is pulverized to 1200 mesh
Sieve, 48~52 DEG C of Yu Wendu, pressure 8MPa, separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtains
The extract liquor arrived i.e. shaggy-fruited dittany root bark extract.
The Essence for treating diaper rash of the present embodiment includes the component of following mass percent: Artemisinin
10%, shaggy-fruited dittany root bark extract 10%, summer cypress berry extract 10%, collinsonia canadensis extract 10%, Blumea oil 10%, tocopherol
0.8%, surplus is Melaleuca alternifolia leaf oil.
Example IV
Preparing for the Artemisinin of the present embodiment is as follows: dry sweet wormwood is crushed to 280 meshes, Yu Wendu 46~48
DEG C, pressure 5.5MPa, separating pressure 3.9MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor
That is Artemisinin.
Preparing for the shaggy-fruited dittany root bark extract of the present embodiment is as follows: dry shaggy-fruited dittany root skin is pulverized to 1200 mesh
Sieve, 48~52 DEG C of Yu Wendu, pressure 6.5MPa, separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction,
Obtained extract liquor i.e. shaggy-fruited dittany root bark extract.
The Essence for treating diaper rash of the present embodiment includes the component of following mass percent: Artemisinin
8%, shaggy-fruited dittany root bark extract 8%, summer cypress berry extract 8%, collinsonia canadensis extract 8%, Blumea oil 6%, tocopherol
0.7%, surplus is Melaleuca alternifolia leaf oil.
Addition 6% embodiment one prepare Essence, be conventionally made into ointment, be used for infant diaper rash, one
It is used four times, continues one week, observing effect.The results showed that can effectively resist baby containing Essence prepared by embodiment one
Youngster's diaper rash cures red hip, and routine use can also have the function that prevention.
The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to preferred embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that, it can modify to technical solution of the present invention
Or equivalent replacement should all cover without departing from the objective and range of technical solution of the present invention in claim of the invention
In range.Technology not described in detail in the present invention, shape, construction portion are well-known technique.
Claims (10)
1. a kind of for treating the Essence of diaper rash, which is characterized in that including Artemisinin, shaggy-fruited dittany root bark extract,
Skin berry extract, collinsonia canadensis extract, Blumea oil, Melaleuca alternifolia leaf oil, tocopherol.
2. according to claim 1 a kind of for treating the Essence of diaper rash, which is characterized in that the Essence includes
The component of following mass percent: Artemisinin 3~10%, shaggy-fruited dittany root bark extract 3~10%, summer cypress berry extract 3~
10%, collinsonia canadensis extract 3~10%, Blumea oil 3~10%, tocopherol 0.5~0.8%, surplus are Melaleuca alternifolia
Leaf oil.
3. according to claim 2 a kind of for treating the Essence of diaper rash, which is characterized in that the sweet wormwood extracts
Object, shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract mass ratio be 1:1:1:1, the sweet wormwood extracts
Object, shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract are all made of supercritical CO2Extraction extracts to obtain.
4. according to claim 3 a kind of for treating the Essence of diaper rash, which is characterized in that the Essence includes
The component of following mass percent: Artemisinin 5%, shaggy-fruited dittany root bark extract 5%, summer cypress berry extract 5%, collinsonia canadensis
Extract 5%, Blumea oil 5%, tocopherol 0.6%, surplus are Melaleuca alternifolia leaf oil.
5. according to claim 4 a kind of for treating the Essence of diaper rash, which is characterized in that the Artemisinin
Prepare it is as follows: dry sweet wormwood is crushed to 200~300 meshes, 46~48 DEG C of Yu Wendu, 4~6MPa of pressure, separating pressure
3~4MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor i.e. Artemisinin.
6. according to claim 5 a kind of for treating the Essence of diaper rash, which is characterized in that the shaggy-fruited dittany root skin mentions
Take preparing for object as follows: dry shaggy-fruited dittany root skin pulverized to 1200 meshes, 48~52 DEG C of Yu Wendu, 6~8MPa of pressure,
Separating pressure 7MPa, CO2Supercritical CO is carried out under the conditions of flow 15L/h2Extraction, obtained extract liquor i.e. shaggy-fruited dittany root bark extract.
7. -6 is any described a kind of for treating the preparation method of the Essence of diaper rash according to claim 1, feature exists
In, it is described the preparation method is as follows: take Artemisinin, shaggy-fruited dittany root bark extract, summer cypress berry extract, collinsonia canadensis extract into
Row microwave oscillation mixes, and Blumea oil, Melaleuca alternifolia leaf oil and tocopherol is then added and stirs and evenly mixs to get Essence is arrived.
8. according to claim 7 a kind of for treating the preparation method of the Essence of diaper rash, which is characterized in that described
Microwave oscillation is specially to vibrate 5min in 30~35 DEG C of temperature, power 300W, frequency 500MHz condition.
9. -6 is any described a kind of for treating the application of the Essence of diaper rash according to claim 1, which is characterized in that institute
Spray use can be mixed to prepare with water by stating Essence, or is added to smear to smear in emulsifiable paste and be used.
10. according to claim 9 a kind of for treating the application of the Essence of diaper rash, which is characterized in that the essence
Content of the magnificent liquid in spray or smearing emulsifiable paste is 3~8%.
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| CN201910114339.7A CN109620778A (en) | 2019-02-14 | 2019-02-14 | A kind of Essence and the preparation method and application thereof for treating diaper rash |
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| CN201910114339.7A CN109620778A (en) | 2019-02-14 | 2019-02-14 | A kind of Essence and the preparation method and application thereof for treating diaper rash |
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