CN109620768A - Polypeptide targets factor coniplexes - Google Patents

Polypeptide targets factor coniplexes Download PDF

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Publication number
CN109620768A
CN109620768A CN201811378022.6A CN201811378022A CN109620768A CN 109620768 A CN109620768 A CN 109620768A CN 201811378022 A CN201811378022 A CN 201811378022A CN 109620768 A CN109620768 A CN 109620768A
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China
Prior art keywords
parts
polypeptide
coniplexes
factor
targets
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Pending
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CN201811378022.6A
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Chinese (zh)
Inventor
范梦婷
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Individual
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Priority to CN201811378022.6A priority Critical patent/CN109620768A/en
Publication of CN109620768A publication Critical patent/CN109620768A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The present invention provides a kind of polypeptides to target factor coniplexes, and the polypeptide targeting factor coniplexes include following components in parts by weight: 1-3 parts of polypeptide targeting factor, 15-25 parts of polysaccharide, 8-15 parts of extract, 3-8 parts of pepper element, 2-5 parts of wintergreen, 0.5-1 parts of active carbon, 45-55 parts of distilled water.The present invention provides a kind of polypeptide targeting factor coniplexes and mixes at a specific ratio using polypeptide as raw materials such as targeting factors and polysaccharide, to body with good health-care effect.

Description

Polypeptide targets factor coniplexes
Technical field
The present invention relates to biological health fields more particularly to a kind of polypeptide to target factor coniplexes.
Background technique
With the development of society, more and more people start to pay attention to the health care of chest, lymph and body other organs Get up.People would generally wipe some body lotions, play some health-care effects, but many body lotion addition on the market at present Some additives being harmful to the human body, for a long time using harmful to health.In addition, the body lotion of the prior art is applied on skin, It can stop the pore of skin, so that skin inside and air insulated, to be easy to cause the symptoms such as allergy.
The many active materials of human body be all in the form of peptide existing for.Peptide be related to human body hormone, nerve, cell growth and Each field of reproduction, importance are to adjust the physiological function of each system and cell in vivo, activate related enzyme system in vivo, promote The permeability of intermediate supersession film has the function of that targeting penetrates.
Polysaccharide be it is a kind of as different sugar units by natural polymer made of glucosides key connection, it universally present in from It is safe and non-toxic in right boundary, there is extraordinary biocompatibility and biological degradability.
It is retrieved according to related data of the inventor to this field, there is presently no discoveries to be applied to body for polypeptide and polysaccharide The relevant report of cream.
Summary of the invention
The main purpose of the present invention is to provide a kind of polypeptides to target factor coniplexes, using polypeptide as targeting factor, with And the raw materials such as polysaccharide, it mixes at a specific ratio, there is good health-care effect to body.
In order to achieve the above objectives, the technical scheme of the present invention is realized as follows:
An aspect of of the present present invention provides a kind of polypeptide targeting factor coniplexes, and the polypeptide targeting factor coniplexes include following heavy Measure the component of part: 1-3 parts of polypeptide targeting factor, 15-25 parts of polysaccharide, 8-15 parts of extract, 3-8 parts of pepper element, wintergreen 2-5 Part, 0.5-1 parts of active carbon, 45-55 parts of distilled water.
It preferably, further include 2-5 parts of glycerol.
Preferably, the polypeptide targeting factor are as follows: arginine-glycine-aspartic acid polypeptide.
Preferably, the polysaccharide includes: 5-10 parts of chitosan, 5-8 parts of glucose, 5-7 parts of fructose.
Preferably, the extract includes: 3-5 parts of oil of ginger, 2-5 parts of Flos Carthami extract, 3-5 parts of safflower essential oil.
Preferably, the polypeptide targeting factor coniplexes application field includes: face frost, body lotion.
Preferably, polypeptide targeting factor coniplexes include following components in parts by weight: 2 parts of polypeptide targeting factor, more 20 parts of sugar, 12 parts of extract, pepper plain 5 parts, 3 parts of wintergreen, 0.8 part of active carbon, 50 parts of distilled water.
Preferably, the preparation method of the polypeptide targeting factor coniplexes, includes the following steps:
Step 1: it extracts: fresh ginger is extracted, ginger liquid is removed, oil of ginger is made;Safflower is extracted, obtain Flos Carthami extract With safflower essential oil;
Step 2: mixing: by 1-3 parts of polypeptide targeting factor, 15-25 parts of polysaccharide, 8-15 parts of extract, 3-8 parts of pepper element, Chinese ilex Oily 2-5 parts of mixing, stirs evenly, and using pulverizer, is added distilled water 45-55 parts, is stirred for uniformly, obtaining polypeptide targeting factor Mixture;
Step 3: charing process: being added active carbon 0.5-1 parts in the polypeptide targeting factor cocktails described in step 2, stirring is equal It is even, it obtains becoming product;
Step 4: heating: semi-finished product described in step 3 are heated, and temperature setting is 50~55 DEG C, heating time 30-60min, The polypeptide targeting factor coniplexes are made.
Preferably, the polypeptide targeting factor coniplexes are paste.
Preferably, the active carbon is powdered, and granularity is 800-1000 mesh.
Beneficial effects of the present invention:
1. the present invention provides a kind of polypeptide targeting factor coniplexes, using polypeptide as raw materials such as targeting factors and polysaccharide, with spy Fixed ratio mixing, has good health-care effect to body.
2. present invention could apply to body lotion, face frost can also be applied to, can be directly applied on skin, to human body without Side effect.It should be understood that menstrual woman and the pregnancy women disabling present invention.
3. the present invention, as polypeptide targeting factor, has targeting well using arginine-glycine-aspartic acid polypeptide Function is penetrated, skin can be promoted to absorb inside rapid osmotic to skin.
4, the present invention can be promoted blood circulation using pepper element, play the role of activating microcirculation and removing stasis medicinal.Oil of ginger and wintergreen Mutually collaboration, can generate heat, dissipation stagnation resolvation, stimulation cycle, oily dissipating bind knot effect, Flos Carthami extract and safflower essential oil are mutually assisted Together, thrombus can be alleviated, improve microcirculation, have dredgingization mass-dissipating efficacy to mammary gland.
5, present invention addition active carbon enables to polypeptide targeting factor coniplexes product of the invention loose porous, applies After skin, so that coming into full contact with inside skin with air, allergy can be prevented, human body relaxes to avoid the pore for stopping skin It is moderately high.And granularity of activated carbon of the present invention is 800-1000 mesh, it is very thin, it can promote and polypeptide targeting factor of the present invention With merging for polysaccharide, it can be blended in one completely.
6. the present invention can speed up hydrolysis, obtained polypeptide target rapidly using three kinds of chitosan, glucose, fructose sugar mixing To factor cocktails, and then polypeptide targeting factor coniplexes are obtained, improves industrial production efficiency.
Specific embodiment
Technical solution of the present invention is clearly and completely described combined with specific embodiments below, it is to be understood that under Described embodiments are only a part of the embodiments of the present invention in face, instead of all the embodiments.
Embodiment one
The embodiment of the present invention one provides a kind of polypeptide targeting factor coniplexes, including following components in parts by weight: polypeptide targeting Factor 1kg, polysaccharide 15kg, extract 8kg, pepper element 3kg, wintergreen 2kg, active carbon 0.5kg, distilled water 45L, glycerol 2kg.
The polypeptide targeting factor are as follows: arginine-glycine-aspartic acid polypeptide.
The polysaccharide includes: chitosan 5kg, glucose 5kg, fructose 5kg.
The extract includes: oil of ginger 3kg, Flos Carthami extract 2kg, safflower essential oil 3kg.
The polypeptide targeting factor coniplexes application field includes: face frost, body lotion.
The preparation method of the embodiment of the present invention one, includes the following steps:
Step 1: it extracts: fresh ginger is extracted, ginger liquid is removed, oil of ginger is made;Safflower is extracted, obtain Flos Carthami extract With safflower essential oil;
Step 2: mixing: by polypeptide targeting factor 1kg, polysaccharide 15kg, extract 8kg, pepper element 3kg, wintergreen 2kg, glycerol 2kg mixing, stirs evenly, and using pulverizer, distilled water 45L is added, and is stirred for uniformly, obtaining polypeptide targeting factor cocktails;
Step 3: charing process: being added active carbon 0.5kg in the polypeptide targeting factor cocktails described in step 2, stir evenly, It obtains becoming product;
Step 4: heating: semi-finished product described in step 3 are heated, and temperature setting is 50 DEG C, heating time 30min, and cream is made The polypeptide of shape targets factor coniplexes.
Embodiment two
The embodiment of the present invention two provides a kind of polypeptide targeting factor coniplexes, including following components in parts by weight: polypeptide targeting Factor 3kg, polysaccharide 25kg, extract 15kg, pepper element 8kg, wintergreen 5kg, active carbon 1kg, distilled water 55L, glycerol 5kg.
The polypeptide targeting factor are as follows: arginine-glycine-aspartic acid polypeptide.
The polysaccharide includes: chitosan 10kg, glucose 8kg, fructose 7kg.
The extract includes: oil of ginger 5kg, Flos Carthami extract 5kg, safflower essential oil 5kg.
The polypeptide targeting factor coniplexes application field includes: face frost, body lotion.
The preparation method of the embodiment of the present invention two, includes the following steps:
Step 1: it extracts: fresh ginger is extracted, ginger liquid is removed, oil of ginger is made;Safflower is extracted, obtain Flos Carthami extract With safflower essential oil;
Step 2: mixing: by polypeptide targeting factor 3kg, polysaccharide 25kg, extract 15kg, pepper element 8kg, wintergreen 5kg, glycerol 5kg mixing, stirs evenly, and using pulverizer, distilled water 55L is added, and is stirred for uniformly, obtaining polypeptide targeting factor cocktails;
Step 3: charing process: active carbon 1kg is added in the polypeptide targeting factor cocktails described in step 2, stirs evenly, obtains To becoming product;
Step 4: heating: semi-finished product described in step 3 are heated, and temperature setting is 55 DEG C, heating time 60min, and cream is made The polypeptide of shape targets factor coniplexes.
Embodiment three
The embodiment of the present invention three provides a kind of polypeptide targeting factor coniplexes, comprising: polypeptide targeting factor 2kg, polysaccharide 20kg, Extract 12kg, pepper element 5kg, wintergreen 3kg, active carbon 0.8kg, distilled water 50L.
The polypeptide targeting factor are as follows: arginine-glycine-aspartic acid polypeptide.
The polysaccharide includes: chitosan 8kg, glucose 6kg, fructose 6kg.
The extract includes: oil of ginger 4kg, Flos Carthami extract 4kg, safflower essential oil 4kg.
The polypeptide targeting factor coniplexes application field includes: face frost, body lotion.
The preparation method of the embodiment of the present invention three, includes the following steps:
Step 1: it extracts: fresh ginger is extracted, ginger liquid is removed, oil of ginger is made;Safflower is extracted, obtain Flos Carthami extract With safflower essential oil;
Step 2: mixing: polypeptide targeting factor 2kg, polysaccharide 20kg, extract 12kg, pepper element 5kg, wintergreen 3kg are mixed, It stirs evenly, using pulverizer, distilled water 5L is added, be stirred for uniformly, obtaining polypeptide targeting factor cocktails;
Step 3: charing process: being added active carbon 0.8kg in the polypeptide targeting factor cocktails described in step 2, stir evenly, It obtains becoming product;
Step 4: heating: semi-finished product described in step 3 are heated, and temperature setting is 52 DEG C, heating time 45min, and cream is made The polypeptide of shape targets factor coniplexes.
It should be understood that active carbon used in the embodiment of the present invention be it is powdered, granularity be 800-1000 mesh.
By experimental analysis and comparison, polypeptide targeting factor coniplexes of the invention are put into effect test examination, it will be of the invention Polypeptide targets factor coniplexes as body lotion and wipes body, and 20 people's tests, 19 people have is good for chest effect well, and only 1 It is a invalid.
The above description is merely a specific embodiment, but simultaneously difference is limited to this to protection scope of the present invention, any Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.

Claims (10)

1. a kind of polypeptide targets factor coniplexes, which is characterized in that the polypeptide targeting factor coniplexes include following weight parts Component: it is 1-3 parts of polypeptide targeting factor, 15-25 parts of polysaccharide, 8-15 parts of extract, 3-8 parts of pepper element, 2-5 parts of wintergreen, living Property 0.5-1 parts of charcoal, 45-55 parts of distilled water.
2. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that further include 2-5 parts of glycerol.
3. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that the polypeptide targeting factor are as follows: essence Propylhomoserin-Gly-Asp polypeptide.
4. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that the polysaccharide includes: chitosan 5- 10 parts, 5-8 parts of glucose, 5-7 parts of fructose.
5. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that the extract includes: oil of ginger 3-5 parts, 2-5 parts of Flos Carthami extract, 3-5 parts of safflower essential oil.
6. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that the polypeptide targets factor coniplexes Application field includes: face frost, body lotion.
7. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that the polypeptide targets factor coniplexes Including following components in parts by weight: 2 parts of polypeptide targeting factor, 20 parts of polysaccharide, 12 parts of extract, pepper element 5 parts, 3 parts of wintergreen, 0.8 part of active carbon, 50 parts of distilled water.
8. polypeptide according to claim 1 targets factor coniplexes, which is characterized in that the polypeptide targets factor coniplexes Preparation method, include the following steps:
Step 1: it extracts: fresh ginger is extracted, ginger liquid is removed, oil of ginger is made;Safflower is extracted, obtain Flos Carthami extract With safflower essential oil;
Step 2: mixing: by 1-3 parts of polypeptide targeting factor, 15-25 parts of polysaccharide, 8-15 parts of extract, 3-8 parts of pepper element, Chinese ilex Oily 2-5 parts of mixing, stirs evenly, and using pulverizer, is added distilled water 45-55 parts, is stirred for uniformly, obtaining polypeptide targeting factor Mixture;
Step 3: charing process: being added active carbon 0.5-1 parts in the polypeptide targeting factor cocktails described in step 2, stirring is equal It is even, it obtains becoming product;
Step 4: heating: semi-finished product described in step 3 are heated, and temperature setting is 50~55 DEG C, heating time 30-60min, The polypeptide targeting factor coniplexes are made.
9. polypeptide according to claim 8 targets factor coniplexes, which is characterized in that the polypeptide targets factor coniplexes For paste.
10. polypeptide according to claim 8 targets factor coniplexes, which is characterized in that the active carbon be it is powdered, Granularity is 800-1000 mesh.
CN201811378022.6A 2018-11-19 2018-11-19 Polypeptide targets factor coniplexes Pending CN109620768A (en)

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Publication number Priority date Publication date Assignee Title
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CN102068396A (en) * 2009-11-20 2011-05-25 戚冬梅 Acne cream
CN104288002A (en) * 2014-09-13 2015-01-21 上海梦之队国际贸易有限公司 Preparation method of energy supplement compound for cosmetics
CN104622736A (en) * 2015-01-06 2015-05-20 厦门医学高等专科学校 Tibetan medicinal extract skin-care product and preparation method thereof
CN105982831A (en) * 2015-02-09 2016-10-05 郭宗卫 Cosmetic containing active peptide
CN106749517A (en) * 2016-11-29 2017-05-31 中山大学 A kind of polysaccharide derivates containing polypeptide targeting factor and preparation method thereof
CN107157961A (en) * 2017-05-15 2017-09-15 华子昂 Nurse one's health mammary gland disease and have newborn film of moulding beautification function and preparation method thereof to female breast
CN107206047A (en) * 2014-12-31 2017-09-26 汇恩斯株式会社 Treat burn and glaucoma, reduce wrinkle of skin and trichogenous comprising the composition containing the peptide of RGD motif or its fragment
CN108685838A (en) * 2018-08-04 2018-10-23 芜湖慧宇商贸有限公司 A kind of preparation method of the anti-wrinkle Essence containing safflower extract

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* Cited by examiner, † Cited by third party
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CN102068396A (en) * 2009-11-20 2011-05-25 戚冬梅 Acne cream
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CN107206047A (en) * 2014-12-31 2017-09-26 汇恩斯株式会社 Treat burn and glaucoma, reduce wrinkle of skin and trichogenous comprising the composition containing the peptide of RGD motif or its fragment
CN104622736A (en) * 2015-01-06 2015-05-20 厦门医学高等专科学校 Tibetan medicinal extract skin-care product and preparation method thereof
CN105982831A (en) * 2015-02-09 2016-10-05 郭宗卫 Cosmetic containing active peptide
CN106749517A (en) * 2016-11-29 2017-05-31 中山大学 A kind of polysaccharide derivates containing polypeptide targeting factor and preparation method thereof
CN107157961A (en) * 2017-05-15 2017-09-15 华子昂 Nurse one's health mammary gland disease and have newborn film of moulding beautification function and preparation method thereof to female breast
CN108685838A (en) * 2018-08-04 2018-10-23 芜湖慧宇商贸有限公司 A kind of preparation method of the anti-wrinkle Essence containing safflower extract

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