CN109619300A - A kind of sucking pig takes orally iron supplementary and preparation method thereof - Google Patents
A kind of sucking pig takes orally iron supplementary and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
- A23K10/28—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin from waste dairy products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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Abstract
The present invention provides a kind of sucking pigs to take orally iron supplementary and preparation method thereof, belongs to animal health product scope.Sucking pig provided by the invention take orally iron supplementary can take into account a variety of sucking pigs must vitamin, micro element mineral, electrolyte, energy and protein, while by oral way supplement can effectively avoid caused by needle injection stress, the negative effects such as cross-infection and pathogen propagation.And have both improvement intestinal health, the effect of promoting nutrient absorption, iron injection is mended compared to injection, nutrient is more comprehensively, the problems such as avoiding limping, hematocystis, high cross-infection and death and culling rate after stress, injecting because of injection bring promotes the probiotics (bacillus coagulans) of intestinal health, Chinese medical extract (Radix Astragali, Radix Angelicae Sinensis) that can effectively facilitate intestinal health, inhibit enteropahtogenic microganism growth to colonize, reduce diarrhea rate, promote absorption of nutrient ingredients, promote immunity promotion and fast-growth.
Description
Technical field
The invention belongs to animal health product technical fields more particularly to a kind of sucking pig to take orally iron supplementary and its preparation side
Method.
Background technique
Due to only storing 25~50 milligrams of iron in newborn piglet body, metabolism needs 7~10 milligrams of iron daily, and in breast milk
Enough iron cannot be provided, fed so must be taken in by external source.Traditionally generally 3 ages in days mend 1.5 millis after piglet birth
It rises, 15 ages in days mend 2.0 milliliters.But it as the intensive degree of China's pig industry is deepened, fine-grained management is reinforced, previously raises pigs
Industry individually must health product the negative effect of culture efficiency is also gradually highlighted.Sucking pig of wherein coming into being mends making extensively for iron injection
It is also increasingly paid close attention to brought side effect and damage for people.Such as injection allergy, stress it is big, injection is dead, hemotoncus tumour
Generation, cross-infection etc..
Holmgren showed about 10% piglet after first day of life is injected and mends iron needle in experimental study in 1996
Suffer from polyarthirtis.If in injection in the 5th day, the risk for suffering from this disease substantially reduced (p < 0.01).If using mouth
If taking iron supplementary replacement, then illness rate further substantially reduces (p < 0.001)
According to upper described, due to being contained only other than iron, selenium in conventional injection injection iron supplementary formula, other important vitamins etc.
Nutrient is difficult to compound addition in injection.In injection since injection itself is hypertonic solution and the intrinsic stimulation of chalybeate
Irritability caused by property causes sucking pig limping, hemotoncus, tumour, irritability immunity degradation or even stress be dead, infuses in addition
It is difficult to frequently to replace syringe needle when penetrating operation and also results in the negative effects such as cross infections are propagated and excitation infection causes death.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of sucking pigs to take orally iron supplementary and preparation method thereof.The present invention mentions
The sucking pig of confession, which takes orally iron supplementary, can take into account the necessary vitamin of a variety of sucking pigs, micro element mineral, electrolyte, energy and albumen
Matter, and can be avoided harm caused by needle injection.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of sucking pigs to take orally iron supplementary, and every liter of sucking pig takes orally the group that iron supplementary includes following quality
Point:
Preferably, the Chinese medical extract includes Astragalus Root P.E and angelica extract.
Preferably, the viable count of the bacillus coagulans is 200*108cfu/g。
The present invention also provides the preparation methods that sucking pig described in above-mentioned technical proposal takes orally iron supplementary, comprising the following steps:
First emulsification after vitamin A, vitamine D3, vitamin E, Tween 80 and TBHQ are mixed obtains A material；
Ferrous glycine, selenium and cobalt are mixed, B material is obtained；
Vitamin B2, vitamin B12, niacinamide, folic acid and high steady vitamin C are mixed, C material is obtained；
It is poured into the purified water of 45~50 DEG C of heating after xanthan gum, whey powder, potassium sorbate, glucose are mixed, obtains D
Material；
45~50 DEG C are heated to after B material is mixed with D material, obtains mixed liquor；
It after A material is heated to 45~50 DEG C, is added in the mixed liquor and carries out the second emulsification, obtain O/W type cream
Change suspended liquid；
C material is slowly added into the O/W type to emulsify in suspended liquid, obtains premixed liquid；
Bacillus coagulans, sorbierite, sweetener, milk essence and Chinese medical extract are sequentially added in the premixed liquid,
It obtains the sucking pig and takes orally iron supplementary.
Preferably, the vitamin A is added in the form of Retinol Palmitate.
Preferably, the selenium is added in the form of yeast selenium.
Preferably, the cobalt is added in the form of cobaltous sulfate.
Preferably, the temperature of first emulsification is 45~50 DEG C.
Preferably, the temperature of second emulsification is 45~50 DEG C.
Preferably, it further includes cooled to room temperature that the C material, which is slowly added into after the O/W type emulsifies in suspended liquid,
The present invention provides a kind of sucking pigs to take orally iron supplementary, and every liter of sucking pig takes orally the group that iron supplementary includes following quality
Point: vitamin A 4,500,000-6,000,000IU；Vitamine D3 1,500,000-3,000,000IU；Vitamin E 5,000,
000-8,000,000mg；Vitamin B2 2,500-4,000mg；Vitamin B12 0.015-0.03mg；High steady vitamin C 8,
000-12,000mg；Niacinamide 10,000-15,000mg；Folic acid 800-1,500mg；Ferrous glycine 45,000-70,000mg；Selenium
70-120mg；Cobalt 700-1,200mg；Chinese medical extract 1,500-2,000mg；Bacillus coagulans 4,000-6,000mg；Xanthan
Glue 10,000mg；Tween 80 35,000-45,000mg；TBHQ 200-400mg；Sorbierite 12,000-16,000mg；Sorbic acid
Potassium 8,000-12,000mg；Whey powder 20,000-40,000mg；Glucose 30,000-50,000mg；Sweetener 4,000-6,
000mg；Milk essence 12,000-16,000mg；Purified water 650,000-750,000mg.Sucking pig provided by the invention is oral to mend iron
Agent can take into account the necessary vitamin of a variety of sucking pigs, micro element mineral, electrolyte, energy and protein, while pass through oral side
Formula supplement can effectively avoid caused by needle injection stress, cross-infection and pathogen the negative effects such as propagate.And have both improvement intestines
The effect of road health, promotion nutrient absorption；The present invention is based on the nutrient research achievement most easily lacked to nascent sucking pig, for
Property addition supplement corresponding nutrient (vitamin A, vitamine D3, vitamin E, vitamin C, niacinamide, folic acid, selenium, whey
Powder, glucose), probiotics (bacillus coagulans) and nutritional ingredient (iron, cobalt, the dimension for promoting hemoglobin and haemocyte to generate
Raw element B2, vitamin B12)；It is light yellow, tool milk fragrance thick liquid that sucking pig, which takes orally iron supplementary appearance, in the present invention, convenient to squeeze
It is pressed on sucking pig oral cavity lingual surface rear portion, is swallowed convenient for sucking pig.All emulsifiers (Tween 80), excipient used in the present invention are (yellow
Virgin rubber), antioxidant (TBHQ), antistaling agent (potassium sorbate), phagostimulant (sweetener, milk essence) be national legislation, industry
Standard approval uses legal ingredient and conventional additives.
Also, the oral iron supplementary of sucking pig provided by the invention, which contains, is easy to intestinal absorption, high bioavilability organic
The nutrition such as chelated iron-ferrous glycine, and the auxiliary vitamin B12, folic acid, the cobalt that promote hemoglobin and erythrocyte to generate at
Point, erythrocyte can be effectively facilitated and generated and content of hemoglobin raising；Containing a variety of help body resisting stress, body peroxide is reduced
The ingredients such as vitamin A, vitamine D3, vitamin E, high steady vitamin C, niacinamide and the selenium of compound matter, vitamin A, vitamin
D3 promotes sucking pig histoorgan and bone growth, meets the metabolism of sucking pig normal growth to the needs of multivitamin, microelement,
Promote the generation (active center element that selenium is glutathione oxidase GSH-PX) of antioxidant in body to promote simultaneously
It into sucking pig immune level, improves health conditions, reduces disease incidence and death and culling rate；The present invention is oral benefit iron and nutrient system
Agent has following characteristics for mending iron injection compared to now widely used injection:
1, nutrient more comprehensively (vitamin A, vitamine D3, vitamin B2, vitamin B12, folic acid, niacinamide, cobalt
Deng), promote immunity to promote and increase the speed of growth.
2, it is not required to inject, avoids limping, hematocystis, cross-infection and death and culling rate after stress, injecting because of injection bring
The problems such as high.
3, promote the probiotics (bacillus coagulans) of intestinal health, Chinese medical extract (Radix Astragali, Radix Angelicae Sinensis) that can effectively facilitate
Intestinal health inhibits enteropahtogenic microganism growth to colonize, reduces diarrhea rate, promote absorption of nutrient ingredients, immunity is promoted to mention
Liter and fast-growth.
Detailed description of the invention
Fig. 1 is the hemoglobin testing result for the sucking pig that the embodiment of the present invention 1 is grown 10 days；
Fig. 2 is 1 test group of the embodiment of the present invention and control group diarrhea rate and death and culling rate statistical result.
Specific embodiment
The present invention provides a kind of sucking pigs to take orally iron supplementary, and every liter of sucking pig takes orally the group that iron supplementary includes following quality
Point:
In the present invention, unless otherwise specified, each component is preferably commercial goods.
In the present invention, the Chinese medical extract preferably includes Astragalus Root P.E and angelica extract.The present invention is to described
The source of Astragalus Root P.E and angelica extract does not have special restriction, using commercial goods well known to those skilled in the art or
Conventional technical means preparation.
In the present invention, the viable count of the bacillus coagulans is preferably 200*108cfu/g。
The present invention also provides the preparation methods that sucking pig described in above-mentioned technical proposal takes orally iron supplementary, comprising the following steps:
First emulsification after vitamin A, vitamine D3, vitamin E, Tween 80 and TBHQ are mixed obtains A material；
Ferrous glycine, selenium and cobalt are mixed, B material is obtained；
Vitamin B2, vitamin B12, niacinamide, folic acid and high steady vitamin C are mixed, C material is obtained；
It is poured into the purified water of 45~50 DEG C of heating after xanthan gum, whey powder, potassium sorbate, glucose are mixed, obtains D
Material；
45~50 DEG C are heated to after B material is mixed with D material, obtains mixed liquor；
It after A material is heated to 45~50 DEG C, is added in the mixed liquor and carries out the second emulsification, obtain O/W type cream
Change suspended liquid；
C material is slowly added into the O/W type to emulsify in suspended liquid, obtains premixed liquid；
Bacillus coagulans, sorbierite, sweetener, milk essence and Chinese medical extract are sequentially added in the premixed liquid,
It obtains the sucking pig and takes orally iron supplementary.
In the present invention, the vitamin A is added preferably in the form of Retinol Palmitate.
In the present invention, the selenium is added preferably in the form of yeast selenium.
In the present invention, the cobalt is added preferably in the form of cobaltous sulfate.
In the present invention, the temperature of first emulsification is preferably 45~50 DEG C.
In the present invention, the mixing of the ferrous glycine, selenium and cobalt is sufficiently mixed with 20~25 revs/min preferably in mixing machine
It closes uniform 10 minutes.
In the present invention, the vitamin B2, vitamin B12, niacinamide, folic acid and high steady ascorbic mixing are preferred
It is sufficiently mixed uniform 8~10 minutes in mixing machine with 20~25 revs/min.
In the present invention, after the purified water for pouring into 45~50 DEG C of heating preferably under 300~350 revs/min of revolving speed
It mixes.In the present invention, product preferably remains 45~50 DEG C after mixing.
In the present invention, the B material is mixed with D material stirs 8~10 minutes preferably under 500 revs/min.
In the present invention, the temperature of second emulsification is preferably 45~50 DEG C.In the present invention, second emulsification is excellent
It is selected under 300~350 revs/min and stirs 15~20 minutes.
In the present invention, after the completion of second emulsification, the second emulsification product is preferably kept for 40~50 DEG C, obtains O/W
Type emulsifies suspended liquid.
In the present invention, it further includes mixed step that the C material, which is slowly added into after the O/W type emulsifies in suspended liquid,
Suddenly, the mixing is stirred 8~10 minutes preferably under 300~350 revs/min.
In the present invention, it is also preferable to include naturally cold after the C material is slowly added into the suspended liquid of the O/W type emulsification
But to room temperature.
In the present invention, it is described sequentially added into premixed liquid bacillus coagulans, sorbierite, sweetener, milk essence and
Chinese medical extract preferably carries out under stirring conditions, and the revolving speed of the stirring is preferably 300~350 revs/min, the stirring
Time is preferably 15~20 minutes.
In the present invention, the oral iron supplementary of the sucking pig, which is preferable over after sucking pig is come into being 24 hours, uses, oral to feed 2-
4mL/ head, 1-2 times/day.
Below with reference to embodiment to a kind of sucking pig provided by the invention take orally iron supplementary and preparation method thereof carry out it is detailed
Illustrate, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
Sucking pig takes orally iron supplementary, and every liter of sucking pig takes orally the component that iron supplementary includes following quality: vitamin A 4,
500,000IU；Vitamine D3 1,500,000IU；Vitamin E 5,000,000mg；Vitamin B2 2,500mg；Vitamin
B120.015mg；High steady vitamin C 8,000mg；Niacinamide 10,000mg；Folic acid 800mg；Ferrous glycine 45,000mg；Selenium
70mg；Cobalt 700mg；Chinese medical extract 1,500mg；Bacillus coagulans 4,000mg；Xanthan gum 10,000mg；Tween 80 35,
000mg；TBHQ 200mg；Sorbierite 12,000mg；Potassium sorbate 8,000mg；Whey powder 20,000mg；Glucose 30,
000mg；Sweetener 4,000mg；Milk essence 12,000mg；Purified water 650,000mg.
The preparation method is as follows:
By vitamin A, vitamine D3, vitamin E, Tween 80 and TBHQ mix after at 45 DEG C first emulsify and maintain 45
DEG C, obtain A material；
20 revs/min in ferrous glycine, yeast selenium and cobaltous sulfate mixing machine are sufficiently mixed uniform 10 minutes, B material is obtained；
Vitamin B2, vitamin B12, niacinamide, folic acid and high steady vitamin C are filled in mixing machine in V-type and filled for 20 revs/min
Divide and be uniformly mixed 8 minutes, obtains C material；
It is poured into the purified water of 45 DEG C of heating after xanthan gum, whey powder, potassium sorbate, glucose are mixed, 300 revs/min
Stirring, mixes well, and thick liquid is made and equilibrium temperature is horizontal, obtains D material；
B material is heated to 45 DEG C in 500 revs/min of stirrings with D material after ten minutes, obtains mixed liquor；
By the A material be heated to 45 DEG C after, be added in the mixed liquor carry out second emulsification, second be emulsified in 300 turns/
Stirring 15 minutes under point, stir and evenly mix and equilibrium temperature is horizontal, obtain O/W type and emulsify suspended liquid；
C material is slowly added into the O/W type to emulsify in suspended liquid, 300 revs/min, stirring in 10 minutes is sufficiently mixed
It is down to room temperature (15 DEG C) after even, obtains premixed liquid；
Bacillus coagulans, sorbierite, sweetener, milk essence and Chinese medical extract are sequentially added in the premixed liquid,
Adition process obtains the sucking pig and takes orally iron supplementary in 300 revs/min of interior progress in stirring 15-20 minutes.
Control group --- --- -- the 1st and the 3rd day, 1 times/day, totally 2 times.Each intramuscular injection iron-dextrin 1mL (three smart domestic animal blood
Element, animal pharmaceutical factory, Guangxi Chemical Inst., 150mg/ml)；Experimental period 22 days.
--- sucking pig made from --- -- first day oral 2mL the present embodiment takes orally iron supplementary to test group, after oral for the first time
24 hours, then oral 3mL, altogether twice, experimental period totally 22 days.
Two groups of gene kind --- pellet system (system, Denmark breeding pig kind) is with parity with 24 hours sucking pigs after counterpoise birth.
Every nest is all divided into two processing in test --- test and control group；
Two groups of piglet counterpoises are equal；
Obstetric table feeding, does not reach extraneous source of iron；
It weighs to 10 days sucking pigs of growth, finds that the average weight of test group has reached 3.24kg, without poor through detection
Blood characterization, the average weight of control group are 3kg, and weight gain variation is 240g, and sucking pig uniformity is high in test group group, size gap
Less.
Hemoglobin detection is carried out to the sucking pig of growth 10 days, as a result as shown in Figure 1, Fig. 1 acceptance of the bid ordinate is blood red egg
Bai Hanliang, unit g/100mL (sucking pig hemoglobin normal value is changed to 10g by U.S. NRC the 9th edition, and 8g indicates critical anaemia).By
Fig. 1 can be seen that experimental group and characterize without anaemia, and erythrocyte hematocrit is normal, and hemoglobin level passes through without significant change, explanation
Oral ferrous supplement method can satisfy sucking pig and mend the requirement of iron and hematopoiesis to chalybeate substantially.
It weighs to 22 days sucking pigs of growth, finds that the average weight of test group has reached 5.95kg, without poor through detection
Blood characterization, the average weight of control group are 5.57kg, and weight gain variation is 380g, it is known that, sucking pig uniformity is high in test group group,
Size gap is little, compared with injecting chalybeate, hence it is evident that improves growth performance, weight gain performance is significantly better than control group；.
Diarrhea rate is carried out to test group and control group and death and culling rate counts, as a result as shown in Fig. 2, can be seen by Fig. 2
Out, the diarrhea rate and death and culling rate of test group are significantly lower than control group, illustrate that test group can effectively improve work efficiency, reduce and stress, subtract
(Holmgren shows that about 10% piglet injects benefit iron in first day of life in experimental study in 1996 for few cross-infection
Polyarthirtis in needle future trouble.If in injection in the 5th day, the risk for suffering from this disease substantially reduced (p < 0.01).If made
If being replaced with oral iron supplementary, then illness rate further substantially reduces (p < 0.001)), promote weight gain, reduce diarrhea, improve
Uniformity reduces dead naughty, increase benefit.
Embodiment 2
Sucking pig takes orally iron supplementary, and every liter of sucking pig takes orally the component that iron supplementary includes following quality: vitamin A 6,
000,000IU；Vitamine D3 3,000,000IU；Vitamin E 8,000,000mg；Vitamin B2 4,000mg；Vitamin B12
0.03mg；High steady vitamin C 12,000mg；Niacinamide 15,000mg；Folic acid 1,500mg；Ferrous glycine 70,000mg；Selenium
120mg；Cobalt 1,200mg；Chinese medical extract 2,000mg；Bacillus coagulans 6,000mg；Xanthan gum 10,000mg；Tween
8045,000mg；TBHQ 400mg；Sorbierite 16,000mg；Potassium sorbate 12,000mg；Whey powder 40,000mg；Glucose
50,000mg；Sweetener 6,000mg；Milk essence 16,000mg；Purified water 750,000mg.
Preparation method is same as Example 1, takes orally iron supplementary to sucking pig made from embodiment 2 and is used for growth of suckling pigs, obtains
Result it is similar to Example 1.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of sucking pig takes orally iron supplementary, which is characterized in that every liter of sucking pig takes orally the component that iron supplementary includes following quality:
2. sucking pig according to claim 1 takes orally iron supplementary, which is characterized in that the Chinese medical extract includes astragalus extraction
Object and angelica extract.
3. sucking pig takes orally iron supplementary according to claim 1, which is characterized in that the viable count of the bacillus coagulans is
200*108cfu/g。
4. the preparation method that any one of claims 1 to 3 sucking pig takes orally iron supplementary, which comprises the following steps:
First emulsification after vitamin A, vitamine D3, vitamin E, Tween 80 and TBHQ are mixed obtains A material；
Ferrous glycine, selenium and cobalt are mixed, B material is obtained；
Vitamin B2, vitamin B12, niacinamide, folic acid and high steady vitamin C are mixed, C material is obtained；
It is poured into the purified water of 45~50 DEG C of heating after xanthan gum, whey powder, potassium sorbate, glucose are mixed, obtains D material；
45~50 DEG C are heated to after B material is mixed with D material, obtains mixed liquor；
It after A material is heated to 45~50 DEG C, is added in the mixed liquor and carries out the second emulsification, it is outstanding to obtain the emulsification of O/W type
Turbid body；
C material is slowly added into the O/W type to emulsify in suspended liquid, obtains premixed liquid；
Bacillus coagulans, sorbierite, sweetener, milk essence and Chinese medical extract are sequentially added in the premixed liquid, are obtained
The sucking pig takes orally iron supplementary.
5. the preparation method according to claim 4, which is characterized in that the vitamin A is with the shape of Retinol Palmitate
Formula is added.
6. the preparation method according to claim 4, which is characterized in that the selenium is added in the form of yeast selenium.
7. the preparation method according to claim 4, which is characterized in that the cobalt is added in the form of cobaltous sulfate.
8. the preparation method according to claim 4, which is characterized in that the temperature of first emulsification is 45~50 DEG C.
9. the preparation method according to claim 4, which is characterized in that the temperature of second emulsification is 45~50 DEG C.
10. the preparation method according to claim 4, which is characterized in that the C material is slowly added into the O/W type emulsification
It further include cooled to room temperature after in suspended liquid.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111972559A (en) * | 2020-07-29 | 2020-11-24 | 湖北远昊生物科技有限公司 | Formula and application of piglet iron-supplementing oral paste |
| CN112890006A (en) * | 2021-05-07 | 2021-06-04 | 北京大北农动物保健科技有限责任公司 | Hematopoietic nutritional feed additive, preparation method and application thereof |
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| CN112890006A (en) * | 2021-05-07 | 2021-06-04 | 北京大北农动物保健科技有限责任公司 | Hematopoietic nutritional feed additive, preparation method and application thereof |
| CN112890006B (en) * | 2021-05-07 | 2021-08-13 | 北京大北农动物保健科技有限责任公司 | Hematopoietic nutritional feed additive, preparation method and application thereof |
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