CN108936025A - A kind of boar microemulsion formulation and preparation method thereof - Google Patents
A kind of boar microemulsion formulation and preparation method thereof Download PDFInfo
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- CN108936025A CN108936025A CN201811127624.4A CN201811127624A CN108936025A CN 108936025 A CN108936025 A CN 108936025A CN 201811127624 A CN201811127624 A CN 201811127624A CN 108936025 A CN108936025 A CN 108936025A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
Abstract
The invention belongs to field of animal feed, disclose a kind of boar microemulsion formulation, include in the microemulsion formulation of every 1000 parts by weight: the emulsifier of 11-15 parts by weight, the assistant for emulsifying agent of 2-4 parts by weight, the retinyl acetate of 1-2 parts by weight, the cod-liver oil of 1-2 parts by weight, the folic acid of 0.5-1 parts by weight, the vitamin E of 3-4 parts by weight and surplus Chinese medicine extract；The Chinese medicine extract of every 100 parts by weight is extracted to obtain by motherwort 200-300 parts by weight, ramulus cinnamomi 150-200 parts by weight, 10-30 parts of fructus gardeniae, 10-20 parts of Radix Glycyrrhizae by percolation；C14-16 alkyl glycosides of the emulsifier by 10-20wt%, the Tween 80 composition of 80-90wt%；The assistant for emulsifying agent is ethyl alcohol.Simultaneously the invention also discloses the preparation method of said preparation, the advantage of said preparation is to reduce feelings rate of returning, improve piglet survival ratio and promote piglet growth, reduces sow postpartum morbidity.
Description
Technical field
The present invention relates to field of animal feed, and in particular to a kind of boar microemulsion formulation and preparation method thereof.
Background technique
There are many link of the raising need concern of sow, such as the prevention of feeding environment, method for breeding, disease, feed
Collocation etc., if any of the above-described environment control is bad, to the length in the oestrus of sow, pregnant success rate, piglet survival ratio,
Piglet weight, sow and the diarrhea of piglet control situation etc. have an impact.
So judging the quality of sow raising, need to go to judge in terms of sow and piglet two.
CN201610676574.X discloses a kind of sow feed, and the sow feed is made of following material: dregs of beans, swollen
Change corn flour, bone meal, fish meal, cactus, aloe, pitaya peel, pawpaw skin, bagasse, traditional Chinese medicine powder；Additive in its feed
Without any chemical addition agent, vitamin, iron, zinc, calcium, various trace elements and amino acid rich in can be mentioned to sow
High enough nutrition, improves sow immunity of organisms, is conducive to sow healthy growth development, improves sow fertility, favorably
It in the absorption of sow, improves food conversion ratio, reduces cost.
CN201710808837.2 discloses a broad sow Chinese medicine fodder, by including that basal feed, salt and Chinese herbal medicine mix
It closes, the Chinese herbal medicine is made by the raw material of following parts by weight: rumex root 10~12, calamus root 6~8, Centipeda minima 8~
13, flax 10~15, silk tree wood skin 5~7, Chinese honey locust 3~5, the fruit of Cherokee rose 2~3, waxgourd peel 7~10, cordate houttuynia 8~15；The medium-height grass
Medicine feed is physilogical characteristics, growth performance and each stage prone disease for pig, and each Chinese herbal medicine collocation is rationally, at low cost, is tied
Pig is closed for the tolerance of Chinese medicine and the needs of prone disease, has and helps spleen stomach invigorating, sterilizing and anti-virus, prophyiaxis and promoting growth, simultaneously
The effect of promoting reproduction, supplementing the nutrients；Sow can not only be supplied and grow sufficient nutrition, sow immunity can also be enhanced,
Accelerate it to the absorption of feed, be effectively improved sow reproductive performance, number born alive increases economic benefit.
But above-mentioned data document considers only and matches to each traditional Chinese medicinal components progress 5, sends out in actual breeding process
It is existing, if Chinese medicine additive amount is excessive, certain negative effect can be generated to female swine rearing, and to improve farrowing rate, contracting
The needs such as subestrus are added with larger quantities, are not too convenient in use, and have certain negative shadow
It rings.
Summary of the invention
The object of the present invention is to provide a kind of boar microemulsion formulations and preparation method thereof；Microemulsion formulation of the invention is using cream
Vitamin A. D. E is effectively formed micella by liquid, improves sow for the assimilation effect of vitamin.Meanwhile emulsion system benefit
It is wrapped up in for the water insoluble ingredients in Chinese medicine percolating liquid, improves the assimilation effect of sow.
As an important inventive point of the invention, using composite emulsifying system, by Tween 80 and non-ionic alkyl sugar
Glycosides is compounded, and wherein Tween 80 is main emulsifier, and alkyl glycosides can be improved the strength and stability of micella, avoid
Micella destroys in homogenizing process.Simultaneously, it is most important that, alkyl glycosides has certain sterilization and immune effect, and Wei Sheng
Water insoluble ingredients in plain A and Chinese medicine percolating liquid can be merged effectively, reduced Gilt Uterus intimitis, kept away
The generation exempted from sow postpartum osteoporosis, reduce hoof slight crack.
Concrete scheme of the invention is as follows: a kind of boar microemulsion formulation, includes in the microemulsion formulation of every 1000 parts by weight:
The emulsifier of 11-15 parts by weight, the assistant for emulsifying agent of 2-4 parts by weight, the retinyl acetates of 1-2 parts by weight, 1-2 parts by weight
Cod-liver oil, the folic acid of 0.5-1 parts by weight, the vitamin E of 3-4 parts by weight and surplus Chinese medicine extract；
The Chinese medicine extract of every 100 parts by weight is by motherwort 200-300 parts by weight, ramulus cinnamomi 150-200 parts by weight, fructus gardeniae
10-30 parts, 10-20 parts of Radix Glycyrrhizae are extracted to obtain by percolation；
C14-16 alkyl glycosides of the emulsifier by 10-20wt%, the Tween 80 composition of 80-90wt%；
The assistant for emulsifying agent is ethyl alcohol.
In above-mentioned boar microemulsion formulation, the specification of the retinyl acetate is 2,800,000 IU/g.
In above-mentioned boar microemulsion formulation, include in the microemulsion formulation of every 1000 parts by weight: the emulsification of 12-14 parts by weight
Agent, the assistant for emulsifying agent of 2.5-3.5 parts by weight, the retinyl acetate of 1.3-1.8 parts by weight, 1.2-1.7 parts by weight fish liver
The Chinese medicine extract of oil, the folic acid of 0.6-0.8 parts by weight, the vitamin E of 3.5-3.8 parts by weight and surplus；
The Chinese medicine extract of every 100 parts by weight is by motherwort 230-270 parts by weight, ramulus cinnamomi 170-190 parts by weight, fructus gardeniae
15-25 parts, 12-17 parts of Radix Glycyrrhizae are extracted to obtain by percolation.
The boar microemulsion formulation further includes following parts by weight of component: the bacillus licheniformis of 4-7 parts by weight, 2-8 weight
Measure the plant enzyme of part.
Viable count is 7 × 105CFU/g in the Bacillus licheniformis powder-3×1010CFU/g。
Meanwhile the invention also discloses a kind of preparation method of boar microemulsion formulation as described above, include the following steps:
Step 1: retinyl acetate, cod-liver oil, vitamin E, emulsifier, assistant for emulsifying agent being mixed evenly to be formed
Uniform oily phase；
Step 2: by Chinese medicine extract, folic acid mixing for standby use；
Step 3: the water phase that step 2 obtains mutually being subjected to vacuum emulsification with the oil that step 1 obtains and homogeneous obtains micro emulsion system
Agent.
In the preparation method of above-mentioned boar microemulsion formulation, the Chinese medicine extract the preparation method comprises the following steps:
Step 21: motherwort, ramulus cinnamomi, fructus gardeniae, Radix Glycyrrhizae are crushed into 20-25 mesh powder；
Step 22: powder being impregnated with the ethyl alcohol for the 75vol% for being equivalent to 3-4 times of powder weight；
Step 23: percolation being carried out to the powder after immersion using the ethyl alcohol of 70-75vol% and is extracted to obtain the final product.
In the preparation method of above-mentioned boar microemulsion formulation, the step 3 includes the following steps:
Step 31: oil being mutually pre-added in emulsion tank, the water phase that step 2 obtains is added in the case of stirring；
Step 32: after emulsion tank is sealed, decompression is allowed to emulsify under vacuum conditions, and mixing speed when emulsification is
2000-3000r/min；Emulsifying temperature is room temperature；
Step 33: the solution that step 2 is obtained carries out reflux homogeneous；Homogenization pressure is 70-80MPa；
Step 34: decompression, cooling and filtering.
The invention has the benefit that
Vitamin A. D. E is effectively formed micella using lotion by microemulsion formulation of the invention, improves sow for dimension
The assimilation effect of raw element.Meanwhile emulsion system is conducive to wrap up the water insoluble ingredients in Chinese medicine percolating liquid, improves female
The assimilation effect of pig.
As one of important inventive point of the invention, using composite emulsifying system, by Tween 80 and non-ionic alkyl sugar
Glycosides is compounded, and Tween 80 and alkyl glycosides HBL value all with higher are capable of forming stable oil-in-water system, wherein
Tween 80 is main emulsifier, and the strength and stability of micella can be improved in alkyl glycosides, avoids the micella in homogenizing process
It destroys.Simultaneously, it is most important that, alkyl glycosides has certain sterilization and immune effect, and vitamin A and Chinese medicine seep
The water insoluble ingredients filtered in liquid can be merged effectively, reduced Gilt Uterus intimitis, avoided sow postpartum sclerotin
Generation that is loose, reducing hoof slight crack.
The two of important inventive point of the invention are, have been carried out in the selection of Chinese medicine extract preferably, with motherwort, osmanthus
Branch is monarch drug in a prescription, is to make medicine with Radix Glycyrrhizae using fructus gardeniae as ministerial drug, wherein motherwort has promoting blood circulation for regulating menstruation, and inducing diuresis for removing edema is clearing heat and detoxicating
The effect of, ramulus cinnamomi has effects that warming meridians and promoting circulation of qi, this two tastes monarch drug in a prescription 5, which is matched, effectively to shorten the oestrus of sow, and is had
Effect improves pregnancy rate, the feelings of aphtha and oedema that the fructus gardeniae as ministerial drug can effectively avoid sow postpartum from being easy to appear
Condition occurs, and finds by raising experiment, is to have for being obviously shortened the reduction of oestrus of sow phase and returning feelings rate to improve pregnancy rate
It obviously helps, is reconciled using Radix Glycyrrhizae, keep entire Chinese medicine preparation simple and obvious effect.
The three of important inventive point of the invention are, by various plants it is fermented after, be rich in a variety of amino acid, a variety of dimensions are given birth to
Element, plant polyose body, nucleic acid substances, mycoprotein, the nutriments such as minerals have and adjust the metabolism of boar parent and immune function
Can, boar boar reproductive development can be promoted, effective sperm concentration of boar boar sperm is improved, reduce the deformity of sperm
Rate, hence it is evident that improve and produce smart ability, significantly enhance the probability of becoming pregnant of boar, and average farrowing rate and piglet survival ratio, and promote
Into the quality of sow milk secretory volume and milk.
Specific embodiment
Below with reference to embodiment, the invention will be further described, but does not constitute any limitation of the invention, any
In the modification for the limited times that scope of the invention as claimed is made, still in scope of the presently claimed invention.
Unless otherwise specified, dosage is parts by weight or weight percent in the present embodiment and comparative example.
Embodiment 1:
Step 1: by 2 parts of retinyl acetates (2,800,000 IU/g), 1 part of cod-liver oil, 3.5 parts of vitamin Es, 1.3 parts of C14-
16 alkyl glycosides, 11.7 parts of Tween 80s, 3 parts of dehydrated alcohols are mixed evenly to form uniform oily phase；
Step 2: by 976 parts of Chinese medicine extracts, 0.8 part of folic acid mixing for standby use；
Wherein, Chinese medicine extract is prepared by following process:
270 portions of motherworts, 170 parts of ramulus cinnamomi, 20 portions of fructus gardeniaes, 15 portions of Radix Glycyrrhizaes are crushed into 20-25 mesh powder；With
The ethyl alcohol of 1660 parts of 75vol% impregnates powder, impregnates 5 days, collects soak, and will be after powder and soak separation
Powder is subjected to percolation extraction, specifically uses the ethyl alcohol of 75vol% with the speed of 400ml per minute to the powder after immersion
End carries out percolation extraction, until medical fluid is thin out, collects percolate, after percolate and soak are mixed, by decompression operation
Ethyl alcohol is removed, is then placed in concentration pan and carries out heating concentration, obtain about 135 parts of Chinese medicine extract i.e. water phases.
Step 3: oil being mutually pre-added in emulsion tank, the water phase that step 2 obtains is added in the case of stirring；It will be newborn
After changing tank sealing, decompression is allowed to emulsify under vacuum conditions, and mixing speed when emulsification is 2500r/min；Emulsifying temperature is normal
Temperature；The solution that step 2 is obtained carries out reflux homogeneous；Homogenization pressure is 70-80MPa；Decompression cools down and then passes through miillpore filter
Homogeneous and transparent liquid is obtained by filtration in liquid.
Embodiment 2:
Step 1: by 1 part of retinyl acetate (2,800,000 IU/g), 2 parts of cod-liver oil, 3 parts of vitamin Es, 2.6 parts of C14-16
Alkyl glycosides, 10.4 parts of Tween 80s, 4 parts of dehydrated alcohols are mixed evenly to form uniform oily phase；
Step 2: by 976.5 parts of Chinese medicine extracts, 0.5 part of folic acid mixing for standby use；
Wherein, Chinese medicine extract is prepared by following process:
300 portions of motherworts, 160 parts of ramulus cinnamomi, 10 portions of fructus gardeniaes, 20 portions of Radix Glycyrrhizaes are crushed into 20-25 mesh powder；With
The ethyl alcohol of 1960 parts of 75vol% impregnates powder, impregnates 7 days, collects soak, and will be after powder and soak separation
Powder is subjected to percolation extraction, specifically uses the ethyl alcohol of 75vol% with the speed of 500ml per minute to the powder after immersion
End carries out percolation extraction, until medical fluid is thin out, collects percolate, after percolate and soak are mixed, by decompression operation
Ethyl alcohol is removed, is then placed in concentration pan and carries out heating concentration, obtain about 140 parts of Chinese medicine extract i.e. water phases.
Step 3: oil being mutually pre-added in emulsion tank, the water phase that step 2 obtains is added in the case of stirring；It will be newborn
After changing tank sealing, decompression is allowed to emulsify under vacuum conditions, and mixing speed when emulsification is 2500r/min；Emulsifying temperature is normal
Temperature；The solution that step 2 is obtained carries out reflux homogeneous；Homogenization pressure is 70-80MPa；Decompression cools down and then passes through miillpore filter
Homogeneous and transparent liquid is obtained by filtration in liquid.
Embodiment 3:
Step 1: by 1.5 parts of retinyl acetates (2,800,000 IU/g), 1.5 parts of cod-liver oil, 4 parts of vitamin Es, 2.3 parts
C14-16 alkyl glycosides, 12.7 parts of Tween 80s, 2 parts of dehydrated alcohols are mixed evenly to form uniform oily phase；
Step 2: by 976.3 parts of Chinese medicine extracts, 0.7 part of folic acid mixing for standby use；
Wherein, Chinese medicine extract is prepared by following process:
250 portions of motherworts, 180 parts of ramulus cinnamomi, 18 portions of fructus gardeniaes, 20 portions of Radix Glycyrrhizaes are crushed into 20-25 mesh powder；With
The ethyl alcohol of 1872 parts of 75vol% impregnates powder, impregnates 6 days, collects soak, and will be after powder and soak separation
Powder is subjected to percolation extraction, specifically uses the ethyl alcohol of 75vol% with the speed of 500ml per minute to the powder after immersion
End carries out percolation extraction, until medical fluid is thin out, collects percolate, after percolate and soak are mixed, by decompression operation
Ethyl alcohol is removed, is then placed in concentration pan and carries out heating concentration, obtain about 146 parts of Chinese medicine extract i.e. water phases.
Step 3: oil being mutually pre-added in emulsion tank, the water phase that step 2 obtains is added in the case of stirring；It will be newborn
After changing tank sealing, decompression is allowed to emulsify under vacuum conditions, and mixing speed when emulsification is 2500r/min；Emulsifying temperature is normal
Temperature；The solution that step 2 is obtained carries out reflux homogeneous；Homogenization pressure is 70-80MPa；Decompression cools down and then passes through miillpore filter
Homogeneous and transparent liquid is obtained by filtration in liquid.
Embodiment 4
Step S1: 6 parts by weight bean sprouts, 10 parts by weight raspberries, 6 parts by weight malt, 10 parts by weight Chinese toon buds, 4 weights are weighed
Part pawpaw, 5 parts by weight leek, 4 weight of apple, 6 parts by weight jujubes, 4 parts by weight carrots and 6 parts by weight of lemon are measured, are washed
Only, it dries, shreds, defibrination, after sequentially adding 10 parts by weight honey, 20 parts by weight granulated sugar and water, stirring is inoculated with 4 parts by weight
Candida utili bacterium, mix thoroughly, at 28 DEG C, oxygenation ferment 4.5-5.5d, pH value 4.0-4.5, obtain just tunning；
Step S2: first tunning obtained by step S1 is weighed into the bacillus licheniformis that 2 parts by weight are inoculated with 7 parts by weight, is mixed
Even, at 36 DEG C, continuously ferment 6-7d, pH value 3.2-3.8, and fermentation terminates；
Step S3: by step S2 products therefrom through ultrafiltration through membranes, obtaining plant enzyme liquid, spare；
Step S4: by 2 parts of retinyl acetates (2,800,000 IU/g), 1 part of cod-liver oil, 3.5 parts of vitamin Es, 1.3 parts of C14-
16 alkyl glycosides, 11.7 parts of Tween 80s, 3 parts of dehydrated alcohols are mixed evenly to form uniform oily phase；
Step S5: obtaining water phase after 967 parts of Chinese medicine extracts, 0.8 part of folic acid are mixed, spare；
Wherein, Chinese medicine extract is prepared by following process:
270 portions of motherworts, 170 parts of ramulus cinnamomi, 20 portions of fructus gardeniaes, 15 portions of Radix Glycyrrhizaes are crushed into 20-25 mesh powder；With
The ethyl alcohol of 1660 parts of 75vol% impregnates powder, impregnates 5 days, collects soak, and will be after powder and soak separation
Powder is subjected to percolation extraction, specifically uses the ethyl alcohol of 75vol% with the speed of 400ml per minute to the powder after immersion
End carries out percolation extraction, until medical fluid is thin out, collects percolate, after percolate and soak are mixed, by decompression operation
Ethyl alcohol is removed, is then placed in concentration pan and carries out heating concentration, obtain about 135 parts of Chinese medicine extracts；
Step S6: the oil that step S4 is obtained mutually is pre-added in emulsion tank, and step S5 is added in the case of stirring
The plant enzyme liquid that obtained water phase and step S3 obtains；After emulsion tank is sealed, decompression is allowed to emulsify under vacuum conditions,
Mixing speed when emulsification is 2500r/min；Emulsifying temperature is room temperature；The solution that step 2 is obtained carries out reflux homogeneous；Homogeneous
Pressure is 70-80MPa；Then homogeneous and transparent liquid, i.e. micro emulsion system is obtained by filtration by miillpore filter in liquid by decompression, cooling
Agent.
Embodiment 5
Step S1: 10 parts by weight bean sprouts, 6 parts by weight raspberries, 10 parts by weight malt, 6 parts by weight Chinese toon buds, 6 weights are weighed
Part pawpaw, 3 parts by weight leek, 6 weight of apple, 4 parts by weight jujubes, 6 parts by weight carrots and 4 parts by weight of lemon are measured, are washed
Only, it dries, shreds, defibrination, after 20 parts by weight honey, 10 parts by weight granulated sugar and water is added, stirring is inoculated with the production of 7 parts by weight
Protein candidiasis, is mixed thoroughly, and at 28 DEG C, oxygenation ferment 4.5-5.5d, pH value 4.0-4.5 obtain just tunning；
Step S2: first tunning obtained by step S1 is weighed into the bacillus licheniformis that 7 parts by weight are inoculated with 4 parts by weight, is mixed
Even, at 36 DEG C, continuously ferment 6-7d, pH value 3.2-3.8, and fermentation terminates；
Step S3: by step S2 products therefrom through ultrafiltration through membranes, obtaining plant enzyme liquid, spare；
Step S4: by 1 part of retinyl acetate (2,800,000 IU/g), 2 parts of cod-liver oil, 3 parts of vitamin Es, 2.6 parts of C14-16
Alkyl glycosides, 10.4 parts of Tween 80s, 4 parts of dehydrated alcohols are mixed evenly to form uniform oily phase；
Step S5: obtaining water phase after 965.5 parts of Chinese medicine extracts, 0.5 part of folic acid are mixed, spare；
Wherein, Chinese medicine extract is prepared by following process:
300 portions of motherworts, 160 parts of ramulus cinnamomi, 10 portions of fructus gardeniaes, 20 portions of Radix Glycyrrhizaes are crushed into 20-25 mesh powder；With
The ethyl alcohol of 1960 parts of 75vol% impregnates powder, impregnates 7 days, collects soak, and will be after powder and soak separation
Powder is subjected to percolation extraction, specifically uses the ethyl alcohol of 75vol% with the speed of 500ml per minute to the powder after immersion
End carries out percolation extraction, until medical fluid is thin out, collects percolate, after percolate and soak are mixed, by decompression operation
Ethyl alcohol is removed, is then placed in concentration pan and carries out heating concentration, obtain about 140 parts of Chinese medicine extracts；
Step S6: the oil that step S4 is obtained mutually is pre-added in emulsion tank, and step S5 is added in the case of stirring
The plant enzyme liquid that obtained water phase and step S3 obtains；After emulsion tank is sealed, decompression is allowed to emulsify under vacuum conditions,
Mixing speed when emulsification is 2500r/min；Emulsifying temperature is room temperature；The solution that step 2 is obtained carries out reflux homogeneous；Homogeneous
Pressure is 70-80MPa；Then homogeneous and transparent liquid, i.e. micro emulsion system is obtained by filtration by miillpore filter in liquid by decompression, cooling
Agent.
Embodiment 6
Step S1: 8 parts by weight bean sprouts, 7 parts by weight raspberries, 8 parts by weight malt, 8 parts by weight Chinese toon buds, 5 weight are weighed
Part pawpaw, 4 parts by weight leek, 5 weight of apple, 5 parts by weight jujubes, 5 parts by weight carrots and 5 parts by weight of lemon, are cleaned,
It dries, shreds, defibrination, after 15 parts by weight honey, 18 parts by weight granulated sugar and water is added, stirring is inoculated with the production protein vacation of 6 parts by weight
Silk saccharomycete, is mixed thoroughly, and at 28 DEG C, oxygenation ferment 4.5-5.5d, pH value 4.0-4.5 obtain just tunning；
Step S2: first tunning obtained by step S1 is weighed into the bacillus licheniformis that 4 parts by weight are inoculated with 6 parts by weight, is mixed
Even, at 36 DEG C, continuously ferment 6-7d, pH value 3.2-3.8, and fermentation terminates；
Step S3: by step S2 products therefrom through ultrafiltration through membranes, obtaining plant enzyme liquid, spare；
Step S4: by 1.5 parts of retinyl acetates (2,800,000 IU/g), 1.5 parts of cod-liver oil, 4 parts of vitamin Es, 2.3 parts
C14-16 alkyl glycosides, 12.7 parts of Tween 80s, 2 parts of dehydrated alcohols are mixed evenly to form uniform oily phase；
Step S5: obtaining water phase after 966.3 parts of Chinese medicine extracts, 0.7 part of folic acid are mixed, spare；
Wherein, Chinese medicine extract is prepared by following process:
250 portions of motherworts, 180 parts of ramulus cinnamomi, 18 portions of fructus gardeniaes, 20 portions of Radix Glycyrrhizaes are crushed into 20-25 mesh powder；With
The ethyl alcohol of 1872 parts of 75vol% impregnates powder, impregnates 6 days, collects soak, and will be after powder and soak separation
Powder is subjected to percolation extraction, specifically uses the ethyl alcohol of 75vol% with the speed of 500ml per minute to the powder after immersion
End carries out percolation extraction, until medical fluid is thin out, collects percolate, after percolate and soak are mixed, by decompression operation
Ethyl alcohol is removed, is then placed in concentration pan and carries out heating concentration, obtain about 146 parts of Chinese medicine extracts；
Step S6: the oil that step S4 is obtained mutually is pre-added in emulsion tank, and step S5 is added in the case of stirring
The plant enzyme liquid that obtained water phase and step S3 obtains；After emulsion tank is sealed, decompression is allowed to emulsify under vacuum conditions,
Mixing speed when emulsification is 2500r/min；Emulsifying temperature is room temperature；The solution that step 2 is obtained carries out reflux homogeneous；Homogeneous
Pressure is 70-80MPa；Then homogeneous and transparent liquid, i.e. micro emulsion system is obtained by filtration by miillpore filter in liquid by decompression, cooling
Agent.
Comparative example 1
It is substantially the same with embodiment 1, different places is, alkyl glycosides is free of in step 1, and Tween 80 is 13 parts.
Comparative example 2
It is substantially the same with embodiment 1, different places is, fructus gardeniae, motherwort 280 are free of in Chinese medicine extract
Part, ramulus cinnamomi is 175 parts, and Radix Glycyrrhizae is 20 parts.
Comparative example 3
It is substantially the same with embodiment 1, different places is, is free of retinyl acetate, and the dosage of cod-liver oil increases to
2 parts, the dosage of vitamin E increases to 4.5 parts.
Sow raising experiment
1, the selection of sample
Sample selection example 1, embodiment 6, comparative example 1, comparative example 2, comparative example 3 and water are as sample, wherein water
As blank sample.
2, experimental subjects
Subjects select 2-4 parity, healthy binary sow 120 of gestation (85 days) similar in the expected date of childbirth, random to divide
It is 6 groups, every group 20, separated raising.6 groups are added embodiment 1 (experiment A group), (the experiment B of embodiment 6 in basal feed respectively
Group), comparative example 1 (experiment C group), comparative example 2 (experiment D group), comparative example 3 (experiment E group) and water (control group), 6 groups of uses
Identical basal feed.
Test period is antenatal 30 days to postpartum 60 days.
Agent of feed for pregnancy sow formula are as follows: 58.65 parts of corn, 5 parts of wheat bran, 4 parts of soya-bean oil, 20.5 parts of dregs of beans, enzymolysis protein powder 3
Part, 2.5 parts of imported fish meal, 0.15 part of lysine, 0.05 part of threonine, 0.1 part of valine, 0.05 part of mould inhibitor, pregnant sow
4 parts of compound premix；
Feed for lactating sow formula are as follows: 58.65 parts of corn, 5 parts of wheat bran, 4 parts of soya-bean oil, 20.5 parts of dregs of beans, enzymolysis protein powder 3
Part, 2.5 parts of imported fish meal, 0.15 part of lysine, 0.05 part of threonine, 0.1 part of valine, 0.05 part of mould inhibitor, lactating sow
4 parts of compound premix；
Embodiment 1, embodiment 6, comparative example 1, comparative example 2, comparative example 3 and blank sample are with the ratio of 1ml/kg feed
It is added in corresponding experimental group；Specifically, the product of embodiment 1 is added in the feed of experiment A group；Embodiment 6 is added
Into the feed of the feed of experiment B group；Comparative example 1 is added in the feed of experiment C group；Comparative example 2 is added to the feeding of experiment D group
In material；Comparative example 3 is added in the feed of experiment E group；Water is added in the feed of blank control group.
The case where pig house is carried out according to conventional sow way to manage, observes oestrus of sow, the in heat 12-24 hours
Artificial insemination breeding, every second of the artificial insemination breeding of progress in 12 hours.
Sow reproductive performance is recorded during test, litter size, number born alive, stillborn foetus number including sow, mummy number, mother
Pig post-partum estrus interval, piglet weigth at birth and the weight gain of 21 age in days piglet nests, and calculate average daily gain.It is extensive to record sow postpartum
Multiple situation, heat including sow breed, become pregnant and health status (incidence of constipation, diarrhea and other diseases).Record is young
Pig growth performance, including grice diarrhoea rate, average daily gain.
4, experimental result
Table one: the influence to sow reproductive performance
Table two: the influence to sow Recovery
| Group | The heat date/d | Breeding date/d | Return feelings rate | Pregnant success rate |
| Test A group | 5-6 | 4-5 | 0 | 100 |
| Test B group | 4-5 | 4-5 | 0 | 100 |
| Test C group | 5-6 | 5-7 | 0 | 100 |
| Test D group | 6-8 | 6-7 | 10 | 90 |
| Test E group | 5-7 | 4-5 | 0 | 100 |
| Blank control group | 6-8 | 6-9 | 20 | 80 |
Table three: health status during the entire reproduction of sow
| Group | Diarrhea/example | Anorexia/example | Hoof slight crack/example | Survival rate |
| Test A group | 0 | 0 | 0 | 100 |
| Test B group | 0 | 0 | 0 | 100 |
| Test C group | 1 | 3 | 2 | 100 |
| Test D group | 2 | 1 | 0 | 100 |
| Test E group | 0 | 3 | 2 | 100 |
| Blank control group | 2 | 3 | 3 | 90 |
Table four: the influence to piglet growth performance
| Group | 7 age in days daily gains | 14 age in days daily gains | 21 age in days daily gains |
| Test A group | 1.75±0.13 | 1.21±0.05 | 2.23±0.3 |
| Test B group | 1.83±0.14 | 1.26±0.06 | 2.27±0.14 |
| Test C group | 1.72±0.12 | 1.20±0.04 | 2.21±0.11 |
| Test D group | 1.69±0.14 | 1.19±0.06 | 2.16±0.11 |
| Test E group | 1.67±0.11 | 1.17±0.05 | 2.13±0.13 |
| Blank control group | 1.67±0.12 | 1.15±0.03 | 2.08±0.10 |
Table five: the influence to grice diarrhoea rate
| Group | 1-7 age in days | 1-14 age in days | 1-21 age in days |
| Test A group | 0.28±0.09 | 0.21±0.06 | 0.20±0.04 |
| Test B group | 0.21±0.08 | 0.19±0.05 | 0.18±0.03 |
| Test C group | 0.25±0.07 | 0.21±0.04 | 0.19±0.04 |
| Test D group | 0.26±0.06 | 0.22±0.05 | 0.22±0.04 |
| Test E group | 0.34±0.09 | 0.25±0.03 | 0.21±0.03 |
| Blank control group | 0.37±.09 | 0.26±0.02 | 0.23±0.05 |
By above-mentioned test it can be concluded that
1, formula of the invention can effectively improve breeding success rate, can promote the growth of piglet, be conducive to sow and exist
Health in cyclostage；
2, the speed of growth and health of the piglet by breast-feeding can be made using bacillus licheniformis and plant enzyme
Situation is significantly improved.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (8)
1. a kind of boar microemulsion formulation, which is characterized in that include in the microemulsion formulation of every 1000 parts by weight: 11-15 parts by weight
Emulsifier, the assistant for emulsifying agent of 2-4 parts by weight, the retinyl acetate of 1-2 parts by weight, the cod-liver oil of 1-2 parts by weight, 0.5-1 weight
Measure the folic acid, the vitamin E of 3-4 parts by weight and the Chinese medicine extract of surplus of part；The Chinese medicine extract of every 100 parts by weight by
Motherwort 200-300 parts by weight, ramulus cinnamomi 150-200 parts by weight, 10-30 parts of fructus gardeniae, 10-20 parts of Radix Glycyrrhizae by percolation extract
It obtains；
C14-16 alkyl glycosides of the emulsifier by 10-20wt%, the Tween 80 composition of 80-90wt%；
The assistant for emulsifying agent is ethyl alcohol.
2. boar microemulsion formulation according to claim 1, which is characterized in that the specification of the retinyl acetate is
2800000 IU/g.
3. boar microemulsion formulation according to claim 1, which is characterized in that wrapped in the microemulsion formulation of every 1000 parts by weight
Contain: the emulsifier of 12-14 parts by weight, the assistant for emulsifying agent of 2.5-3.5 parts by weight, 1.3-1.8 parts by weight retinyl acetate,
In the cod-liver oil of 1.2-1.7 parts by weight, the folic acid of 0.6-0.8 parts by weight, the vitamin E of 3.5-3.8 parts by weight and surplus
Medicament extracting solution；
The Chinese medicine extract of every 100 parts by weight is by motherwort 230-270 parts by weight, ramulus cinnamomi 170-190 parts by weight, fructus gardeniae 15-
25 parts, 12-17 parts of Radix Glycyrrhizae are extracted to obtain by percolation.
4. boar microemulsion formulation according to claim 1, which is characterized in that the boar microemulsion formulation further includes following
Parts by weight of component: the bacillus licheniformis of 4-7 parts by weight, 2-8 parts by weight plant enzyme.
5. boar microemulsion formulation according to claim 4, which is characterized in that viable bacteria in the Bacillus licheniformis powder
Number is 7 × 105CFU/g-3×1010CFU/g。
6. a kind of preparation method of boar microemulsion formulation a method according to any one of claims 1-3, which is characterized in that including walking as follows
It is rapid:
Step 1: retinyl acetate, cod-liver oil, vitamin E, emulsifier, assistant for emulsifying agent are mixed evenly to be formed it is uniform
Oily phase；
Step 2: water phase is obtained after Chinese medicine extract, folic acid are mixed, it is spare；
Step 3: the water phase that step 2 obtains mutually being subjected to vacuum emulsification with the oil that step 1 obtains and homogeneous obtains microemulsion formulation.
7. the preparation method of boar microemulsion formulation according to claim 6, which is characterized in that the Chinese medicine extract
The preparation method comprises the following steps:
Step 21: motherwort, ramulus cinnamomi, fructus gardeniae, Radix Glycyrrhizae are crushed into 20-25 mesh powder；
Step 22: powder being impregnated with the ethyl alcohol for the 75vol% for being equivalent to 3-4 times of powder weight；
Step 23: percolation being carried out to the powder after immersion using the ethyl alcohol of 70-75vol% and is extracted to obtain the final product.
8. the preparation method of boar microemulsion formulation according to claim 6, which is characterized in that the step 3 includes such as
Lower step:
Step 31: oil being mutually pre-added in emulsion tank, the water phase that step 2 obtains is added in the case of stirring；
Step 32: after emulsion tank is sealed, decompression is allowed to emulsify under vacuum conditions, and mixing speed when emulsification is 2000-
3000r/min；Emulsifying temperature is room temperature；
Step 33: the solution that step 2 is obtained carries out reflux homogeneous；Homogenization pressure is 70-80MPa；
Step 34: decompression, cooling and filtering.
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