CN109602840A - A kind of recurrent aphthous ulcer rehabilitation patch and preparation method thereof - Google Patents
A kind of recurrent aphthous ulcer rehabilitation patch and preparation method thereof Download PDFInfo
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- CN109602840A CN109602840A CN201910131909.3A CN201910131909A CN109602840A CN 109602840 A CN109602840 A CN 109602840A CN 201910131909 A CN201910131909 A CN 201910131909A CN 109602840 A CN109602840 A CN 109602840A
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- 208000002399 aphthous stomatitis Diseases 0.000 title claims abstract description 31
- 230000000306 recurrent effect Effects 0.000 title claims abstract description 29
- 208000020670 canker sore Diseases 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 54
- 239000003814 drug Substances 0.000 claims abstract description 44
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- 239000000284 extract Substances 0.000 claims abstract description 19
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- 238000002156 mixing Methods 0.000 claims abstract description 14
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 12
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 12
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 12
- 241001078983 Tetradium ruticarpum Species 0.000 claims abstract description 12
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- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 11
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- 239000002994 raw material Substances 0.000 claims abstract description 11
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims abstract description 10
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 10
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 10
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 10
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 10
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 10
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- 239000003795 chemical substances by application Substances 0.000 claims description 4
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
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- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The present invention relates to Chinese traditional medicine health care patches more particularly to a kind of recurrent aphthous ulcer rehabilitation patch and preparation method thereof.A kind of recurrent aphthous ulcer rehabilitation patch, external use health patch contains Chinese medicine material extract and substrate, and wherein Chinese medicine material extract is according to parts by weight are as follows: 20 ~ 50 parts of evodia rutaecarpa, 20 ~ 30 parts of radix scutellariae, 10 ~ 30 parts of Fructus Forsythiae, 10 ~ 30 parts of the coptis, 5 ~ 10 parts of arisaema cum bile, 5 ~ 10 parts of Radix picrorrhizae, 5 ~ 10 parts of asparagus fern mountain, 5 ~ 10 parts of honeysuckle flower, 2 ~ 8 parts of rheum officinale, 2 ~ 8 parts of radix scrophulariae and 2 ~ 8 parts of mixing Chinese medicine materials of Radix Glycyrrhizae are extracted and are concentrated；Also, substrate is according to parts by weight are as follows: 1-5 parts of sodium benzoate, 1-5 parts of potassium sorbate, 10-40 parts of modified superfine far-infared ceramic powder, 10-30 parts of negative ion powder, 20-90 parts of aerosil particles.Rehabilitation patch allows raw material to be sufficiently mixed dispersion, and various raw materials are combined by modified obtained ultra-fine far-infared ceramic powder, solves the technical issues of prior art dispersion is bad, fever is uneven, curative effect cannot give full play to.
Description
Technical field
The present invention relates to Chinese traditional medicine health care patch more particularly to a kind of recurrent aphthous ulcer rehabilitation patch and its preparation sides
Method.
Background technique
Recurrent aphthous ulcer is a kind of highest disease of disease incidence, common cold, indigestion, essence in oral keritonocytes
Situations such as refreshing nervous, gloomy not happy, can accidentally cause the generation of the disease, lip, cheek, lingual margin etc. are apt to occur in, in any portion of mucous membrane
Position can occur, but then rare in the complete attached gingiva of angling and hard palate.Age of onset generally between 10~30 years old, women compared with
It is more, can it occur throughout the year.Recurrent aphthous ulcer has self limiting, can be in self-healing in 10 days or so.The disease has periodical, recurrent
And the features such as self limiting.
Modern medicine believes that, recurrent aphthous ulcer has very close relationship with immune first.Some patients show as being immunized
Defect, some patients then show as autoimmune response；Followed by there is relationship with heredity, in clinic, the hair of recurrent aphthous ulcer
Disease has apparent Family inherited inclination, as soon as if parent side or multi-party with recurrent aphthous ulcer, their children are more than common people
It is easy illness；In addition, the breaking-out of recurrent aphthous ulcer, also related with some diseases or symptom, such as disease of digestive system: stomach is burst
Ulcer, duodenal ulcer, chronic or metastatic hepatitis, colitis etc., in addition partial eclipse, indigestion, fever, sleep insufficiency, mistake
Degree fatigue, operating pressure be big, the change of menstrual cycle etc..With one or more factors it is active, be alternately present body and exempt from
The decline of epidemic disease power, causes the frequent breaking-out of recurrent aphthous ulcer.
Ancient physician mostly controls from excess fire, fire of deficiency type opinion, and modern age doctor thinks related with the heart, spleen, stomach, renal dysfunction more, faces
Bed is divided into the types such as flaring up of heart fire, fire excess from yin deficiency, however clinically Dan Conghuo opinion is controlled, though there is short term effect, not can control multiple
Hair, causes the state of an illness touching refractory.It is generally adjusted at present using Chinese medicine, but extract oral is inconvenient, patch means Pasting in skin
On skin, drug can produce a kind of systemic or local action laminar preparation.It is absorbed by skin, and controlled release mechanism can be passed through
Dosage is needed by the state of an illness, quickly, persistently enters whole body.
Currently, the patch of domestic production is mainly patch, and it is mostly rubber ointment, the traditional matrices composition of raw materials used
In, natural rubber is widely used as framework material.Rubber ointment adhesion is strong, easy to use, passes through Transdermal absorption performance office
The effect of portion treatment and systemic therapy, drug effect are significant.But clinically there is also certain limitations in use process for rubber ointment
Property mainly to the irritation and allergic reaction of skin, symptom mainly has skin to itch, inflammation, plays pimple, long bubble, meeting when serious
Cause anaphylactic shock, to reduce the comfort of rubber ointment, safety and validity.
Summary of the invention
For this purpose, the first purpose of the invention is to provide a kind of recurrent aphthous ulcer rehabilitation patch, rehabilitation patch
By modified obtained ultra-fine far-infared ceramic powder, raw material is allowed to be sufficiently mixed dispersion, and various raw materials are organically combined
Get up, solves the technical issues of prior art dispersion is bad, fever is uneven, curative effect cannot give full play to.
A second object of the present invention is to provide a kind of preparation methods of recurrent aphthous ulcer rehabilitation patch.
In order to realize first above-mentioned purpose, present invention employs technical solutions below:
A kind of recurrent aphthous ulcer rehabilitation patch, rehabilitation patch contain Chinese medicine material extract and substrate, and wherein Chinese medicine is former
Expect extract according to parts by weight are as follows: 20 ~ 50 parts of evodia rutaecarpa, 20 ~ 30 parts of radix scutellariae, 10 ~ 30 parts of Fructus Forsythiae, 10 ~ 30 parts of the coptis, gallbladder south
5 ~ 10 parts of star, 5 ~ 10 parts of Radix picrorrhizae, 5 ~ 10 parts of asparagus fern mountain, 5 ~ 10 parts of Honeysuckle flower, 2 ~ 8 parts of rheum officinale, 2 ~ 8 parts of radix scrophulariae and Radix Glycyrrhizae 2 ~ 8
Part mixing Chinese medicine material is extracted and is concentrated；Also, substrate is according to parts by weight are as follows: 1-5 parts of sodium benzoate, potassium sorbate 1-
5 parts, 10-40 parts of modified superfine far-infared ceramic powder, 10-30 parts of negative ion powder, 20-90 parts of aerosil particles.
As a further improvement, wherein Chinese medicine material extract is by according to parts by weight are as follows: 30 ~ 40 parts of evodia rutaecarpa, radix scutellariae
22 ~ 28 parts, 15 ~ 25 parts of Fructus Forsythiae, 15 ~ 25 parts of the coptis, 6 ~ 8 parts of arisaema cum bile, 6 ~ 8 parts of Radix picrorrhizae, 6 ~ 8 parts of asparagus fern mountain, Honeysuckle flower 6 ~ 8
Part, 3 ~ 6 parts of rheum officinale, 3 ~ 6 parts of radix scrophulariae and 3 ~ 6 parts of Radix Glycyrrhizae of mixing Chinese medicine material are extracted and are concentrated.
As a further improvement, wherein Chinese medicine material extract is by according to parts by weight are as follows: 35 parts of evodia rutaecarpa, radix scutellariae 25
Part, 20 parts of Fructus Forsythiae, 20 parts of the coptis, 6 parts of arisaema cum bile, 6 parts of Radix picrorrhizae, 6 parts of asparagus fern mountain, 6 parts of Honeysuckle flower, 4 parts of rheum officinale, 4 parts of radix scrophulariae
It extracts and is concentrated with 4 parts of Radix Glycyrrhizae of mixing Chinese medicine material.
As a further improvement, the parts by weight of substrate are relative to Chinese medicine material, the parts by weight of substrate are relative to Chinese medicine
Raw material is sodium benzoate 2.5-3.5 parts, 3.2-3.8 parts of potassium sorbate, 25-35 parts of modified superfine far-infared ceramic powder, anion
15-25 parts of powder, 30-70 parts of aerosil particles.
As a further improvement, the modified superfine far-infared ceramic powder in health-care patch of the present invention, using coupling agent to remote red
Outer ceramic powder is modified, and coupling agent is added into far-infared ceramic powder, is sufficiently stirred, filtration drying, then air-flow crushing, finally
By changing the surface property of far-infared ceramic powder itself and Chinese medicine material are filled to modified superfine far-infared ceramic powder
Divide dispersion mixing, improves the combination between raw material, have the function that the uniform raising medicament validity of heat generating spot.It is excellent
Choosing, the average grain diameter d of modified superfine far-infared ceramic powder50For 200-2000nm.
As a further improvement, the coupling agent is selected from silane coupling agent or titanate coupling agent.It is preferred that the idol
Joining agent is KH550, KH560, KH570 or KH792, and dosage is 0.1~5% parts by weight of far-infared ceramic powder, preferably 1% weight
Part.
As a further improvement, rehabilitation patch further comprises 10-25 parts of aerosil, diatomite 5-20
Part and polyvinyl alcohol glue 5-20 parts.
As a further improvement, 15-24 parts of aerosil, 10-18 parts of diatomite and polyvinyl alcohol glue 10-15
Part.
Rehabilitation patch of the invention, using following preparation method:
(1) according to formula ratio weigh evodia rutaecarpa, radix scutellariae, Fructus Forsythiae, the coptis, arisaema cum bile, Radix picrorrhizae, asparagus fern mountain, Honeysuckle flower, rheum officinale,
Radix scrophulariae and Radix Glycyrrhizae carry out co-grinding using ultrafine crusher, sieve with 100 mesh sieve；
(2) deionized water is added into obtained powder and carries out infiltration 30 minutes；
The mixture obtained at (3) 100 DEG C to step (2) carries out Chinese medicine liquid extraction, extracts 3 times repeatedly, merge concentration, obtains
Medicament extracting solution, for use；
(4) coupling agent is added into far-infared ceramic powder, is uniformly mixed, 250 DEG C are stirred 30 minutes, washing filtering, vacuum drying,
Using air-flow crushing, average grain diameter d is obtained50For the modified superfine far-infared ceramic powder of 200-2000nm；
(5) by the modified superfine far-infared ceramic powder, negative ion powder of (4) the step of the Chinese medicine extract and formula ratio of step (3),
Sodium benzoate, potassium sorbate are stirred stirring, are kept for 200 DEG C of temperature, mixing speed 200r/min is stirred 40 minutes；
(6) aerosil particles are measured according to composition of raw materials, the heating melting at 185-230 DEG C is added the mixture of step (5), adds
Enter vulcanizing agent injection mold, high temperature vulcanized demoulding obtains rehabilitation patch, wherein high temperature vulcanized temperature is 150-180 DEG C.
Further, rehabilitation of the invention patch is also containing heat preservation temperature control layer, by including aerosil 10-25
Part, 5-20 parts of diatomite and 5-20 parts of polyvinyl alcohol glue；It is preferred that 15-24 parts of aerosil, 10-18 parts of diatomite and poly-
The mixture that 10-15 parts of vinyl alcohol glue is prepared.
Slow down medicament using its structural void degree by addition aerosil and diatomite and directly act on skin
The side effect of skin reconciles Chinese drugs agentia to the burning sensation of skin, controls temperature, obtains the comfortable sense that sticks, and pass through energy storage function
Effect mitigates medicament drug effect, extends pharmacy effect.
In another embodiment, preparation method of the invention includes:
(1) evodia rutaecarpa processed, radix scutellariae, Fructus Forsythiae, the coptis, arisaema cum bile, Radix picrorrhizae, asparagus fern mountain, Honeysuckle flower, big is weighed according to formula ratio
Yellow, radix scrophulariae and Radix Glycyrrhizae carry out co-grinding using ultrafine crusher, sieve with 100 mesh sieve；
(2) deionized water is added in the powder obtained to step (1) and carries out infiltration 30 minutes；
The mixture obtained at (3) 100 DEG C to step (2) carries out Chinese medicine liquid extraction, extracts 3 times repeatedly, merge concentration, obtains
Medicament extracting solution, for use；
(4) coupling agent is added into far-infared ceramic powder, is uniformly mixed, 250 DEG C are stirred 30 minutes, washing filtering, vacuum drying,
Using air-flow crushing, average grain diameter d is obtained50For the modified superfine far-infared ceramic powder of 200-2000nm, for use；
(5) aerosil, diatomite and polyvinyl alcohol glue of formula ratio are taken, it is mixed with the speed of mixing speed 200r/min
Stirring 20 minutes is closed, mixture is obtained；
(6) by the Chinese medicine extract of step (3), step (5) mixture and formula ratio the step of (4) modified superfine far infrared
Ceramic powder, negative ion powder, sodium benzoate, potassium sorbate are stirred stirring, are kept for 200 DEG C of temperature, mixing speed 200r/min
Stirring 40 minutes；
(7) aerosil particles, the heating melting at 185-230 DEG C are measured according to composition of raw materials, the mixture that step (6) are added is added
Sulfide, injects mold, and high temperature vulcanized demoulding obtains rehabilitation patch；Wherein high temperature vulcanized temperature is 180 DEG C.
Compared with prior art, the modified superfine far-infared ceramic powder that the present invention uses is made by specific method of modifying
It obtains far-infared ceramic powder and has excellent surface property, can have good dispersibility with other components, existing skill will not be generated
Health-care patch fever in art is uneven, the incomplete technical problem of drug action；In addition present invention adds silica gas is molten
Glue and diatomite reach control temperature using its textural porosity, alleviate the burn feeling that drug effect continuingly acts on skin generation,
And by energy storage effect extend drug effect play time, while in patient in use, can with appropriate adjustment use the time, can also be more
It is secondary to be repeatedly circulated, it is flexible and convenient to use.
Health-care patch of the invention, which has close to the comfortable of body temperature, sticks impression, while guaranteeing that drug effect can give full play to, and has
There is treatment aphtha and alleviate the malaise symptoms of aphtha local pain, promotes health.Product of the present invention formula constitutes fairly simple, production
Quality is relatively easy to control, and extracted its effective component that obtains of bulk pharmaceutical chemicals makes it be easier to absorb and play drug effect, preferably improves this
The therapeutic effect of invention drug, to provide a kind of traditional Chinese medicine for outer use that the significantly more efficient treatment of energy is grieved.Chinese medicine of the present invention
The preparation method of preparation is simple, stable product quality, not ixoderm skin, be not required to heat, have no toxic side effect, nonirritant, non-sensitization
Property, clinic can be used for a long time.
Specific embodiment
The present invention is further explained combined with specific embodiments below.
Embodiment 1
Rehabilitation patch of the invention, according to weight fraction, formula are as follows: evodia rutaecarpa 350g, radix scutellariae 250g, Fructus Forsythiae 200g, the coptis
200g, arisaema cum bile 60g, Radix picrorrhizae 60g, asparagus fern mountain 60g, Honeysuckle flower 60g, rheum officinale 40g, radix scrophulariae 40g, Radix Glycyrrhizae 40g, sodium benzoate
18 grams, 12 grams of potassium sorbate, 302 grams of modified superfine far-infared ceramic powder, 200 grams of negative ion powder, 600 grams of aerosil particles.It is remote red
Outer 300 grams of powder raw material of ceramics, coupling agent used are KH792, and dosage is 2.0 grams, obtain 302 grams of far infrared ultrafine ceramic powder.Two
180 grams of silica aerogel, 120 grams of diatomite and 100 grams of polyvinyl alcohol glue.
The preparation method is as follows:
(1) according to formula ratio weigh evodia rutaecarpa, radix scutellariae, Fructus Forsythiae, the coptis, arisaema cum bile, Radix picrorrhizae, asparagus fern mountain, Honeysuckle flower, rheum officinale,
Radix scrophulariae and Radix Glycyrrhizae carry out co-grinding using ultrafine crusher, sieve with 100 mesh sieve；
(2) 1200ml deionized water is added in the powder obtained to step (1) and carries out infiltration 30 minutes；
Chinese medicine liquid extraction is carried out to mixture to step (2) at (3) 100 DEG C, is mentioned using conventional medium-sized traditional Chinese medicine extraction system
It takes, extracts 3 times repeatedly, further merge and be concentrated and dried, obtain mixture a, for use；
(4) far-infared ceramic powder is taken, coupling agent KH560 is added thereto, is uniformly mixed, stirs 30 in reaction pot at 250 DEG C
Minute, it takes out, is dried under vacuum 150 minutes after washing filtering with vacuum oven, it is cooling after taking-up, it is placed in commercially available air-flow powder
Air-flow crushing is carried out in broken machine, obtains average grain diameter d50For the modified superfine far-infared ceramic powder of 200-2000nm；
(5) take the traditional Chinese medicine extraction of step (3) be concentrated the modified superfine far-infared ceramic powder of rough material and step (4), negative ion powder,
Sodium benzoate, potassium sorbate are stirred stirring, are kept for 200 DEG C of temperature, and mixing speed 200r/min is stirred 40 minutes, must be mixed
Object c；
(6) aerosil, diatomite and polyvinyl alcohol glue of formula ratio are taken, it is mixed with the speed of mixing speed 200r/min
Stirring 20 minutes is closed, mixture b is obtained；
(7) mixture c obtained in mixture a obtained in step (3) and step (5) is mixed, with mixing speed 250r/
Min is stirred 30 minutes；
(8) painting of mixture obtained in step (7) is pressed on aerosil particles substrate；
(9) mixture b painting will be obtained in step (6) to be pressed on the substrate that step (8) obtains, and obtains external application physical therapy plaster.
(10) about 3-15 rehabilitations can be made according to mold size and actual use dimensional thickness to paste, preferably 2.
Comparative example 1
The formula and embodiment 1 of health-care patch are identical, replace modified superfine far infrared therein with common commercially available far-infared ceramic powder
Ceramic powder, the preparation method is the same as that of Example 1.
Comparative example 2
The formula of health-care patch are as follows: evodia rutaecarpa 350g, radix scutellariae 250g, Fructus Forsythiae 200g, coptis 200g, arisaema cum bile 60g, Radix picrorrhizae 60g,
Asparagus fern mountain 60g, Honeysuckle flower 60g, rheum officinale 40g, radix scrophulariae 40g and Radix Glycyrrhizae 40g.Conventional method prepares rubber ointment.
Comparative example 3
Choose commercially available far infrared health care patch.
Test example 1
Detect the recurrent aphthous ulcer temperature and efficacy time of each embodiment and comparative example.
Temperature and efficacy time evaluation and test are sticked, the results are shown in Table 1:
Table 1 sticks temperature and efficacy time evaluation and test
The experimental results showed that, rehabilitation patch of the present invention, which obviously has, comfortably sticks temperature above, not will cause the burning of skin
Bright sense and adverse reaction, and lasting efficacy time is kept simultaneously.
Test example 2
1.1 general information
It will be diagnosed as recurrent aphthous ulcer (ROU), the characteristics of but also with minor aphtha, and case conduct in recurrent exerbation 1 year or more
Observe object.It is randomly divided into treatment group, control group 1, control group 2, amounts to 120.Wherein treatment group totally 40, male 18, female
22, average age (42.5 ± 12.6) year；Control group 1 totally 40, male, female each 20, average age (39.2 ± 10.6) year；
Totally 40 male 26, female 14 of control group 2, average age (39.5 ± 15.6) year.3 groups of gender, average age are through statistics
Processing, there was no significant difference, there is comparativity.
1.2 treatment method external applications, stick vola Yongquan acupoint, SHENQUE acupoint.Warm water wiped clean is used before sticking.Daily 1
It is secondary, 2~3 acupuncture points every time.Treatment group: rehabilitation patch prepared by embodiment 1, control group 1: comparative example 1, control group 2: comparison
Example 2；3 groups are used continuously 3 months, and carry out follow-up follow-up observation 1 year to study subject.
1.3 criterion of therapeutical effect clinical recoveries: without recurrence in 1 year after medication；Improve: ulcer recurrence interval extend l/2 with
On, ulcer number reduces 1/2 or more, and subjective symptoms is substantially reduced；It is invalid: morbidity interval time without being obviously prolonged, ulcer number
Reduce unobvious, subjective symptoms is unchanged or aggravates instead.
The effective percentage 92.5% that 1.4 3 groups of effective percentage compare treatment group is apparently higher than control group 1 and control group 2, there is statistics
It learns meaning (P < 0.05).It is shown in Table 2.
22 groups of aphtha patient's effective percentage of table compare [n(%)]
| Group | Number of cases | It is effective | Effectively | In vain | Efficient (%) |
| Treatment group | 40 | 26 | 11 | 3 | 92.5% |
| Control group 1 | 40 | 18 | 14 | 8 | 80% |
| Control group 2 | 40 | 10 | 18 | 12 | 70% |
Serious adverse reaction is had no in 1.5 3 groups of adverse reaction therapeutic process, 1 allergic reaction, adverse reaction hair occurs in observation group
Raw rate 2.5%；Then there are 5 allergic reactions in control group 1, and adverse reaction rate 12.5%, it is anti-that 8 allergy then occurs in control group 2
It answers, adverse reaction rate 20%, difference is statistically significant (P < 0.05).
Although a specific embodiment of the invention is hereinbefore described, it is to be understood that above-described embodiment is specific
Example is not considered as limiting the invention, and those skilled in the art are not departing from the principle of the present invention and objective
In the case where, above-described embodiment can be modified and be changed within the scope of the invention.
Claims (10)
1. a kind of recurrent aphthous ulcer rehabilitation patch, the health-care patch contain Chinese medicine material extract and substrate, wherein Chinese medicine material
Extract is according to parts by weight are as follows: 20 ~ 50 parts of evodia rutaecarpa, 20 ~ 30 parts of radix scutellariae, 10 ~ 30 parts of Fructus Forsythiae, 10 ~ 30 parts of the coptis, arisaema cum bile
5 ~ 10 parts, 5 ~ 10 parts of Radix picrorrhizae, 5 ~ 10 parts of asparagus fern mountain, 5 ~ 10 parts of Honeysuckle flower, 2 ~ 8 parts of rheum officinale, 2 ~ 8 parts and 2 ~ 8 parts of Radix Glycyrrhizae of radix scrophulariae
Mixing Chinese medicine material is extracted and is concentrated；Also,
Substrate is according to parts by weight are as follows: 1-5 parts of sodium benzoate, 1-5 parts of potassium sorbate, modified superfine far-infared ceramic powder 10-40
Part, 10-30 parts of negative ion powder and 20-90 parts of aerosil particles；
The modified superfine far-infared ceramic powder, is that coupling agent is added into far-infared ceramic powder, is sufficiently stirred, filtration drying,
Then air-flow crushing obtains modified superfine far-infared ceramic powder.
2. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 1, which is characterized in that Chinese medicine material extract by according to
Parts by weight are as follows: 30 ~ 40 parts of evodia rutaecarpa, 22 ~ 28 parts of radix scutellariae, 15 ~ 25 parts of Fructus Forsythiae, 15 ~ 25 parts of the coptis, 6 ~ 8 parts of arisaema cum bile, recklessly Huang
Even 6 ~ 8 parts, 6 ~ 8 parts of asparagus fern mountain, 6 ~ 8 parts of Honeysuckle flower, 3 ~ 6 parts of rheum officinale, 3 ~ 6 parts of radix scrophulariae and 3 ~ 6 parts of Radix Glycyrrhizae of mixing Chinese medicine material
It extracts and is concentrated.
3. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 1, which is characterized in that the parts by weight of substrate relative to
Chinese medicine material is sodium benzoate 2.5-3.5 parts, 3.2-3.8 parts of potassium sorbate, 25-35 parts of modified superfine far-infared ceramic powder, is born
15-25 parts of ion powder, 30-70 parts of aerosil particles.
4. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 1-3, which is characterized in that described changes
The average grain diameter d of the ultra-fine far-infared ceramic powder of property50For 200-2000nm.
5. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 1-3, which is characterized in that the idol
Join agent and is selected from silane coupling agent or titanate coupling agent.
6. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 5, which is characterized in that the coupling agent is
KH550, KH560, KH570 or KH792, dosage are 0.1~5% parts by weight of far-infared ceramic powder.
7. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 6, which is characterized in that coupling agent dosage is remote red
1% parts by weight of outer ceramic powder.
8. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 1 or 2, which is characterized in that the health care exchange premium one
Step includes aerosil 10-25 parts, 5-20 parts of diatomite and 5-20 parts of polyvinyl alcohol glue.
9. a kind of recurrent aphthous ulcer rehabilitation patch according to claim 8, which is characterized in that aerosil
15-24 parts, 10-18 parts of diatomite and 10-15 parts of polyvinyl alcohol glue.
10. a kind of preparation method of recurrent aphthous ulcer rehabilitation patch, which is characterized in that according to claim 1 any one of -7
The formula of health-care patch is prepared according to following preparation method:
(1) according to formula ratio weigh evodia rutaecarpa, radix scutellariae, Fructus Forsythiae, the coptis, arisaema cum bile, Radix picrorrhizae, asparagus fern mountain, Honeysuckle flower, rheum officinale,
Radix scrophulariae and Radix Glycyrrhizae carry out co-grinding using ultrafine crusher, sieve with 100 mesh sieve；
(2) deionized water is added into obtained powder and carries out infiltration 30 minutes；
The mixture obtained at (3) 100 DEG C to step (2) carries out Chinese medicine liquid extraction, extracts 3 times repeatedly, merge concentration, obtains
Medicament extracting solution, for use；
(4) coupling agent is added into far-infared ceramic powder, is uniformly mixed, 250 DEG C are stirred 30 minutes, washing filtering, vacuum drying,
Using air-flow crushing, average grain diameter d is obtained50For the modified superfine far-infared ceramic powder of 200-2000nm；
(5) by the modified superfine far-infared ceramic powder, negative ion powder of (4) the step of the Chinese medicine extract and formula ratio of step (3),
Sodium benzoate, potassium sorbate are stirred stirring, are kept for 200 DEG C of temperature, mixing speed 200r/min is stirred 40 minutes；
(6) aerosil particles are measured according to composition of raw materials, the heating melting at 185-230 DEG C is added the mixture of step (5), adds
Enter vulcanizing agent injection mold, high temperature vulcanized demoulding obtains health-care patch, wherein high temperature vulcanized temperature is 150-180 DEG C.
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Cited By (2)
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|---|---|---|---|---|
| CN110025718A (en) * | 2019-04-17 | 2019-07-19 | 温州广立生物医药科技有限公司 | A kind of recurrent aphthous ulcer rehabilitation patch and preparation method thereof |
| CN110090263A (en) * | 2019-04-17 | 2019-08-06 | 温州广立生物医药科技有限公司 | A kind of cough and asthma of children health-care patch and preparation method thereof |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110025718A (en) * | 2019-04-17 | 2019-07-19 | 温州广立生物医药科技有限公司 | A kind of recurrent aphthous ulcer rehabilitation patch and preparation method thereof |
| CN110090263A (en) * | 2019-04-17 | 2019-08-06 | 温州广立生物医药科技有限公司 | A kind of cough and asthma of children health-care patch and preparation method thereof |
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