CN109602717A - 一种羟丙甲纤维素空心胶囊及其制备方法 - Google Patents
一种羟丙甲纤维素空心胶囊及其制备方法 Download PDFInfo
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- CN109602717A CN109602717A CN201811579983.3A CN201811579983A CN109602717A CN 109602717 A CN109602717 A CN 109602717A CN 201811579983 A CN201811579983 A CN 201811579983A CN 109602717 A CN109602717 A CN 109602717A
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- hydroxypropyl methylcellulose
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- colloidal solution
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- 239000002775 capsule Substances 0.000 title claims abstract description 69
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 title claims abstract description 37
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 title claims abstract description 37
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 title claims abstract description 32
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims abstract description 32
- 239000000843 powder Substances 0.000 claims abstract description 22
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 18
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 18
- 239000006185 dispersion Substances 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 239000000845 maltitol Substances 0.000 claims abstract description 18
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract description 18
- 229940035436 maltitol Drugs 0.000 claims abstract description 18
- 235000010449 maltitol Nutrition 0.000 claims abstract description 18
- 235000005074 zinc chloride Nutrition 0.000 claims abstract description 16
- 239000011592 zinc chloride Substances 0.000 claims abstract description 16
- 238000010438 heat treatment Methods 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 17
- 238000004321 preservation Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 239000001828 Gelatine Substances 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201811579983.3A CN109602717B (zh) | 2018-12-24 | 2018-12-24 | 一种羟丙甲纤维素空心胶囊及其制备方法 |
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CN201811579983.3A CN109602717B (zh) | 2018-12-24 | 2018-12-24 | 一种羟丙甲纤维素空心胶囊及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN109602717A true CN109602717A (zh) | 2019-04-12 |
CN109602717B CN109602717B (zh) | 2019-12-20 |
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CN201811579983.3A Active CN109602717B (zh) | 2018-12-24 | 2018-12-24 | 一种羟丙甲纤维素空心胶囊及其制备方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112220774A (zh) * | 2020-10-27 | 2021-01-15 | 张晨晗 | 一种植物胶囊及其制备方法 |
CN112641121A (zh) * | 2020-10-10 | 2021-04-13 | 广州启键生物科技有限公司 | 一种羟丙甲基纤维素和海藻多糖的填充空心胶囊制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102614148A (zh) * | 2011-01-31 | 2012-08-01 | 中国科学院海洋研究所 | 一种植物纤维药用空心胶囊及其制备方法 |
CN103830736A (zh) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | 一种淀粉空心胶囊的生产方法 |
CN108619110A (zh) * | 2018-05-31 | 2018-10-09 | 陕西嘉元生物工程有限公司 | 一种纯羟丙甲纤维素空心胶囊的制作工艺 |
-
2018
- 2018-12-24 CN CN201811579983.3A patent/CN109602717B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102614148A (zh) * | 2011-01-31 | 2012-08-01 | 中国科学院海洋研究所 | 一种植物纤维药用空心胶囊及其制备方法 |
CN103830736A (zh) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | 一种淀粉空心胶囊的生产方法 |
CN108619110A (zh) * | 2018-05-31 | 2018-10-09 | 陕西嘉元生物工程有限公司 | 一种纯羟丙甲纤维素空心胶囊的制作工艺 |
Non-Patent Citations (1)
Title |
---|
刘利萍: "羟丙甲基纤维素空心胶囊的研制", 《中国药学杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112641121A (zh) * | 2020-10-10 | 2021-04-13 | 广州启键生物科技有限公司 | 一种羟丙甲基纤维素和海藻多糖的填充空心胶囊制备方法 |
CN112641121B (zh) * | 2020-10-10 | 2022-04-19 | 广州玖洲胶囊生物科技有限公司 | 一种羟丙甲基纤维素和卡拉胶的填充空心胶囊制备方法 |
CN112220774A (zh) * | 2020-10-27 | 2021-01-15 | 张晨晗 | 一种植物胶囊及其制备方法 |
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Denomination of invention: Hydroxypropylmethylcellulose hollow capsule and its preparation method Effective date of registration: 20221109 Granted publication date: 20191220 Pledgee: Jiangsu Nantong Rural Commercial Bank Co.,Ltd. high tech Zone sub branch Pledgor: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Registration number: Y2022980021371 |
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Date of cancellation: 20231103 Granted publication date: 20191220 Pledgee: Jiangsu Nantong Rural Commercial Bank Co.,Ltd. high tech Zone sub branch Pledgor: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Registration number: Y2022980021371 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: A hollow capsule of hydroxypropyl methylcellulose and its preparation method Effective date of registration: 20231108 Granted publication date: 20191220 Pledgee: Jiangsu Nantong Rural Commercial Bank Co.,Ltd. high tech Zone sub branch Pledgor: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Registration number: Y2023980064331 |