CN109580932A - A kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument and its application method - Google Patents
A kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument and its application method Download PDFInfo
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- CN109580932A CN109580932A CN201910139307.2A CN201910139307A CN109580932A CN 109580932 A CN109580932 A CN 109580932A CN 201910139307 A CN201910139307 A CN 201910139307A CN 109580932 A CN109580932 A CN 109580932A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
Abstract
The present invention relates to a kind of Full-automatic magnetic beads entry joint inspection detection analysis instruments, including mainframe, sideslip rail, it is loaded component and manipulator, the mainframe lower end is equipped with bottom plate, transverse plane is equipped with sample area from left to right on the bottom plate, standby three regions in sample area and detection zone, the sample area includes barcode scanning head, suction nozzle position in storehouse, sample bit, detect liquid level, secondary antibody work liquid level, dilute liquid level and run-bake-needle fault position, the standby sample area includes orifice plate position, it is incubated for position and board-washing machine, the application method of the detection analysis instrument includes the following steps: that sample identifies, it is dilute to add sample, diluted sample, sample incubation, prepare cleaning, cleaning, secondary antibody is incubated for, addition detection liquid, detection reading.The registration, pretreatment and detection reading that sample may be implemented in the detection analysis instrument are full-automatic, and without human intervention, detection sensitivity is high, detection efficiency is high, accuracy is high, entry joint inspection detection can be achieved.
Description
Technical field
The present invention relates to biological monitoring technical fields, and in particular to a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument
And its application method.
Background technique
With the development of science and technology with the fast lifting of medical technology, vitro diagnostic techniques are also more and more important, are widely applied
In scientific research and clinical field, for disease diagnosis, prevent, treat and health monitoring provide really and accurately data according to
According to.Also increasingly by everybody attention, full-automatic detection analysis instrument is full-automatic detection analysis instrument for vitro detection
The instrument of certain specified chemical ingredient in body fluid is measured according to photoelectric colorimetry principle.Due to its measuring speed is fast, accuracy is high,
It is small to consume amount of reagent, is used widely at situation of all-level hospitals, epidemic prevention station, family planning services station, is greatly improved routine
The efficiency and income of biochemical investigation.
ELISA is the solid-phase immunoassay method for detecting micro substance in body fluid, is integrated to antigen or antibody
Certain surface of solid phase carriers, and its immunocompetence is kept, it is reacted by the specific binding of antigen and antibody, finally by
Amplification system reacts amplification this antigen and antibody, is converted into receivable signal, to realize the detection to target substance
And analysis, ELISA is generally carried out using the coated mode of microwell plate at present, microwell plate peridium pair micromolecule polypeptide
The effect is relatively poor for coating, and is often not fixed firmly, and causes detection sensitivity low.
Current existing ELISA instrument, which generally requires, is manually entered sample identification number, needs in current a large amount of samples
Under the status of detection, the workload for being manually entered sample identification number is very big, and mistake easily occurs, so as to cause detection knot
Fruit is chaotic, influences medical diagnosis；In addition, existing ELISA instrument is generally adopted by microwell plate coating technique, it is easy
There is the low problem of detection sensitivity；It needs to make to be formed on solid phase carrier with the method for washing during ELISA anti-
Original antibody compound is separated with other substances, and existing ELISA instrument washing process is very very long cumbersome.Therefore it is badly in need of
There is provided a kind of detection sensitivity it is high, it is full-automatic, can entry joint inspection detection analyzer and application method, to promote analysis inspection
The efficiency and accuracy of survey.
Summary of the invention
The present invention is in view of the deficienciess of the prior art, provide that a kind of detection sensitivity is high, full-automatic, detection efficiency
It is high, accuracy is high, can entry joint inspection detection analyzer and application method.
The technical scheme to solve the above technical problems is that a kind of Full-automatic magnetic beads entry joint inspection tests and analyzes
Instrument, the detection analysis instrument include mainframe, sideslip rail, sample-adding component and manipulator, and the mainframe lower end is equipped with bottom plate, institute
It states transverse plane on bottom plate and is equipped with sample area, standby three regions in sample area and detection zone from left to right.
The sample area include barcode scanning head, suction nozzle position in storehouse, sample bit, detection liquid level, secondary antibody work liquid level, dilution liquid level and
Run-bake-needle fault position is successively laid out the barcode scanning head, the suction nozzle position in storehouse, the sample bit and described two in the sample area from left to right
Anti- work liquid level, the secondary antibody work liquid level rear side are equipped with detection liquid level, are equipped with the run-bake-needle fault position, institute on the right side of the detection liquid level
It states and is equipped with the dilution liquid level on rear side of run-bake-needle fault position；Barcode scanning head may be implemented to reduce artificial the barcode scanning record of sample essential information
The workload of registration also can avoid the mistake that artificial registration generates, place clean suction nozzle in suction nozzle position in storehouse, facilitate sample-adding component
Automatic replacement suction nozzle avoids the cross contamination between sample, and storage sample to be detected, detects liquid level, secondary antibody work in sample bit
Make liquid level and dilution liquid level memory puts required respective substance when pattern detection pre-treatment, run-bake-needle fault position is for storing after use more
The suction nozzle changed, and the opening of run-bake-needle fault position upper end is arranged to an one wide narrow shape, and it is automatic to be conducive to sample-adding component
Take off suction nozzle.
The standby sample area includes orifice plate position, is incubated for position and board-washing machine, and the orifice plate position and the incubation position are located at described wash
The rear side of trigger, the orifice plate position are set on the left of the incubation position, and the orifice plate position is equipped with several deep-well plates；The incubation position
Be equipped with several microplates, equipped with temperature-controlling component and shaking assembly inside the incubations position, convenient for be entirely incubated for process it is automatic into
Row；Concussion component is equipped with inside the board-washing machine convenient for being cleaned automatically to sample；Entire standby sample area is mainly used for test sample
This pre-treatment works, and the configuration of related solution is completed using sample-adding component during Sample pretreatment, realizes full-automation.
Readout instrument is equipped in the detection zone, the sample of processing work, is moved to by manipulator before completing in standby sample area
In detection zone, readout instrument carries out the reading of data to the sample, and the readout instrument upper end is equipped with the microplate slot for placing the microplate,
Stablizing for entire microplate places and detects when convenient for detection.
It is equipped with the sideslip rail in the middle part of the mainframe, is connected on the sideslip rail by sliding block and indulges sliding rail, the vertical cunning
It is set on rail there are two parallel slideway, the sample-adding component is clamped by sliding block on one of slideway, is passed through on another slideway
Sliding block is clamped the manipulator, and the setting of sideslip rail and vertical sliding rail, which facilitates, is loaded component and manipulator in the movement of different direction,
Without manual operation, automatically working is realized.
Further, the incubation position further includes being incubated for disk, and the incubation disk upper end is equipped with temperature-controlling component, the temperature control group
Part upper end is equipped with heat conduction aluminum pad, microplate described in the heat conduction aluminum pad upper ends, and aluminum heat conducting plate is convenient for being heated evenly microplate, from
And microplate is made to be easy to be maintained under specific constant temperature, the lower end for being incubated for disk is equipped with the shaking assembly, the vibration
Component includes that vibration motor, vibrating shaft and vibration bottom plate, the vibration motor are fixedly connected with the lower end of the vibrating shaft, the shake
Moving axis upper end is fixedly connected with the incubation disk, and the vibration motor is fixed on the lower end of the vibration bottom plate, and shaking assembly is to set
The automatic vibration for being easy to implement incubation process is set, is incubated for the whole design of position convenient for entire incubation process full-automation progress, nothing
It needs manually individually to handle sample.
Further, the board-washing machine includes shell, pedestal, coaming plate seat, lifting head assembly, X to motor and shakes component,
The shell lower end is fixedly connected with pedestal, and front side is equipped with guide rail on the pedestal, and the lifting head assembly passes through sliding block and guide rail
Clamping, one end of the guide rail are equipped with the X to motor, and the X is connect by synchronous belt with the lifting head assembly to motor,
The transverse shifting of lift head may be implemented to the design of motor and synchronous belt by X, and concussion component, the shake are equipped among the pedestal
It swings component upper end and is fixedly connected with the coaming plate seat, the setting for shaking component may be implemented board-washing machine and carry out automatic cleaning process.
Further, the lifting head assembly includes lifting motor frame, lifting motor, outer cover, hanging plate, board-washing head, board-washing
Needle, lifting motor frame lower end are fixedly connected with the sliding block, and the sliding block is clamped the guide rail of front side on the pedestal, the liter
Drop motor rack is fixedly connected with the lifting motor, and the lifting motor upper end is fixedly connected with the outer cover, parallel on the outer cover
The hanging plate is riveted, the hanging plate side connects the board-washing head, and board-washing head lower end is fixedly connected with several board-washing needles, described
Board-washing head side is equipped with connector, and moving up and down for board-washing needle may be implemented in the setting of lifting motor, draws board-washing convenient for board-washing needle
The connector of liquid on machine in microplate hole, board-washing head side can connect pipeline, convenient for board-washing needle draw liquid discharge and
The introducing of required cleaning solution.
Further, the concussion component includes concussion motor, vibration supporting plate, damper, magnetic sheet and magnetic pole, the concussion
Motor upper end passes through the centre of the vibration supporting plate, and vibration supporting plate has fixed function to concussion motor, under the vibration supporting plate
The quadrangle at end is respectively fixedly connected with the upper end of the damper, and the lower end of the damper is fixedly connected with the pedestal, oscillator
Setting can avoid entire Full-automatic magnetic beads entry joint inspection detection analysis instrument and be shaken, the concussion motor upper end is fixed to be connected
The centre of the magnetic sheet lower end is connect, the magnetic sheet upper end is fixedly connected with several magnetic poles, and coaming plate seat upper surface is equipped with several holes
Hole, the magnetic pole activity pass through the hole of coaming plate seat upper surface, place microplate on coaming plate seat, pass through moving up and down for magnetic sheet
Can be achieved contact of the magnetic pole with microplate with separate.
Further, the sample-adding component includes sample-adding bracket, sample-adding unit and adjusts motor, the sample-adding bracket side
It is connected in the slideway by sliding block, the sample-adding bracket other side is equipped with guide rail, is clamped two on the guide rail of the sample-adding bracket
A sample-adding unit is equipped between two sample-adding units and adjusts motor, and adjusting motor can control two sample-adding units
Spacing, to realize the sample transfer of different spaced positions.
Further, the sample-adding unit includes unit fixed plate, unit rack, moving frame, link block, cell board
Frame, sample-adding motor and syringe pump, the unit fixed plate are clamped by sliding block and the sample-adding bracket, and the unit fixed plate is another
Side is fixedly connected with the side of the unit rack, passes through connection between the other side of the unit rack and the moving frame
Block is clamped mutually, and the upper end of the unit rack is fixedly connected with the sample-adding motor, and the sample-adding motor connects synchronous belt, described
Link block described in synchronous band connection between unit rack and the moving frame, the moving frame lower end are fixedly connected described
Syringe pump, the syringe pump upper end are fixedly connected with injecting motor, and the injecting motor connects the unit grillage by screw rod,
The syringe pump lower end is fixedly connected with sample needle, realizes moving up and down for moving frame by sample-adding motor and synchronous belt, thus
It realizes moving up and down for sample needle, is wrapped on the outside of the sample needle and picks up needle detection thin slice, the needle detection thin slice upper end of picking up passes through
Spring is fixedly connected with the syringe pump, and the setting for picking up needle detection thin slice facilitates the installation of suction nozzle and takes off.
Further, the slideway side of the manipulator clamping is equipped with mobile motor, and the manipulator side is equipped with connection
Block, the mobile motor are connect by synchronous belt with the link block, control moving in parallel for manipulator, the manipulator includes
Housing, telescope motor, fixed plate, expansion plate, handgrip component and handgrip motor, the outer cup of the fixed plate and the expansion plate
There is the housing, the dead plate upper end is fixedly connected with the telescope motor, and the telescope motor passes through described in screw rod connection
Expansion plate, the expansion plate lower end are fixedly connected with the handgrip motor, and the handgrip motor passes through handgrip described in synchronous band connection
Component, telescope motor can be used for controlling the upper and lower flexible of manipulator, handgrip motor can be used for controlling the stretching, extension of handgrip component with
It shrinks, to be easy to grab microplate into the moving process automation for securely realizing microplate.
Further, the bottom plate lower end, which is equipped with, adjusts foot, and the adjusting foot is connect with the base thread, passes through screw thread
Connection can be spirally connected by adjusting the screw thread of foot, realize the adjusting of the Full-automatic magnetic beads entry joint inspection detection analysis instrument height,
When the equipment is placed in the plane of out-of-flatness, the adjustment by adjusting foot may be implemented the equipment and remain balance, avoid
Occur shaking the damage for leading to equipment inner body.
In addition the invention also discloses the application method of the Full-automatic magnetic beads entry joint inspection detection analysis instrument, including it is as follows
Step:
(1) sample identifies: the barcode scanning head identifies corresponding sample bar code on the sample bit, obtains sample information automatically；
(2) addition sample is dilute: the sample needle is moved to the installation that suction nozzle position in storehouse carries out suction nozzle, and the sample needle for installing suction nozzle moves to
The dilution liquid level is drawn on dilution to the deep-well plates in corresponding hole location, until adding enough hole counts, sample needle is mobile
To the run-bake-needle fault position, suction nozzle is taken off；
(3) diluted sample: the sample needle is moved to the installation that suction nozzle position in storehouse carries out suction nozzle, and the sample needle for installing suction nozzle moves to
The sample bit draws sample, then moves the sample needle, the sample of absorption is added to the corresponding hole location of the deep-well plates
In mixed, obtain diluted sample, then draw diluted sample with the sample needle, then move the sample needle and incubated to described
Position is educated, the diluted sample of absorption is added on the incubation position in the hole of the microplate；
(4) sample incubation: all the incubation position is controlled by the temperature-controlling component plus after diluted sample to be measured in microplate
At a constant temperature, it opens the shaking assembly to be shaken, the specific vibration time is set according to pattern detection demand, is completed
Sample incubation；
(5) prepare cleaning: after the completion of sample incubation, manipulator crawl is incubated for the microplate on position, moves to the board-washing machine
On, concussion component opens the high speed concussion with magnetic, then switchs to middling speed concussion, stands after concussion, according to pattern detection need
The time for asking setting high-speed concussion, middling speed concussion and standing, then board-washing head is moved on the microplate, and the board-washing needle siphons away
Liquid in the hole of the microplate；
(6) clean: the magnetic sheet moves down, and cleaning solution is added in corresponding hole on the microplate in board-washing head, and opens institute
Concussion component is stated, the magnetic sheet moves up, and opens the high speed concussion with magnetic, then switchs to middling speed concussion, quiet after concussion
It sets, board-washing head is moved to the microplate, and the board-washing needle siphons away liquid in the hole of the microplate, and one time cleaning process is completed, altogether
It is repeated 3 times cleaning process；
(7) secondary antibody is incubated for: after the completion of the 3rd cleaning, the manipulator grabs the microplate and moves to the incubation position, described to add
Sample needle loads onto suction nozzle, moves to the secondary antibody work liquid level, draws secondary antibody working solution, the corresponding hole location of the microplate is added to, to micro-
Secondary antibody working solution is all added on plate, and the incubation position control is made at a constant temperature by the temperature-controlling component, opens the shake
Dynamic component is shaken, and is completed secondary antibody and is incubated for, then repeatedly step (5) and step (6)；
(8) addition detection liquid: the manipulator grabs the microplate and moves to the incubation position, and the sample needle loads onto suction nozzle,
It moves to the detection liquid level and draws detection liquid, add to the corresponding hole location of the microplate, after the microplate all adds detection liquid, take off
Fall suction nozzle, incubation position is opened the shaking assembly at a temperature of particular constant and is shaken, and continue specific time, stops vibration,
According to the correlated samples needs of detection, specific incubation temperature and vibration time are set；
(9) detection reading: the manipulator grabs the microplate on the incubation position, is put into the readout instrument, the readout instrument
Microplate is read, testing result is obtained.
The beneficial effects of the present invention are: realizing that automatic barcode scanning is registered to sample, reducing the workload manually registered and avoiding
Artificial registration generates mistake；ELISA process is carried out using the coated mode of magnetic bead carrier, and detection sensitivity is high, accurately
Degree is high, and the preprocessing process such as dilution, incubation, cleaning of sample all automate, and automatic constant-temperature, automatic shake may be implemented
It swings, the registration, pretreatment and detection reading that sample may be implemented using the Full-automatic magnetic beads entry joint inspection detection analysis instrument are complete
Automation, without human intervention, avoids the human error and random error in detection process, and the equipment detection sensitivity is high, complete
Automation, detection efficiency is high, accuracy is high, entry joint inspection detection can be achieved.
Detailed description of the invention
Fig. 1 is Full-automatic magnetic beads entry joint inspection detection analysis instrument schematic perspective view in embodiment；
Fig. 2 is bottom plate top view；
Fig. 3 is to be incubated for position schematic perspective view；
Fig. 4 is to be incubated for position top view；
Fig. 5 is the sectional view along A-A in Fig. 4；
Fig. 6 is board-washing machine top view；
Fig. 7 is the sectional view along A-A in Fig. 6；
Fig. 8 is schematic perspective view inside board-washing machine；
Fig. 9 is the schematic perspective view for being loaded component and manipulator；
Figure 10 is the schematic perspective view for being loaded component；
Figure 11 is the inside schematic perspective view of manipulator；
Figure 12 is the schematic perspective view of sliding block；
In figure, 1 mainframe, 2 sideslip rails, 3 sample-adding components, 4 manipulators, 5 bottom plates, 6 sample areas, 7 for sample area, and 8 detection zones, 9 sweep
Harbour, 10 suction nozzle positions in storehouse, 11 sample bits, 12 detection liquid levels, 13 secondary antibodies work liquid level, 14 dilution liquid levels, 15 run-bake-needle fault positions, 16 orifice plates
Position, 17 are incubated for position, and 18 board-washing machines, 19 deep-well plates, 20 microplates, 21 readout instruments, 22 microplate slots, 23 vertical sliding rails, 24 slideways, 25 is sliding
Block, 26 are incubated for disk, 27 temperature-controlling components, 28 heat conduction aluminum pads, 29 vibration motors, 30 vibrating shafts, 31 vibration bottom plates, 32 shells, 33 bottoms
Seat, 34 coaming plate seats, 35 X are to motor, 36 guide rails, 37 synchronous belts, 38 lifting motor framves, 39 lifting motors, 40 outer covers, 41 hanging plates,
42 board-washing heads, 43 board-washing needles, 44 connectors, 45 concussion motors, 46 vibration supporting plates, 47 dampers, 48 magnetic sheets, 49 magnetic poles, 50 sample-addings
Bracket, 51 adjust motor, 52 unit fixed plates, 53 unit racks, 54 moving frames, 55 screw rods, 56 unit grillages, 57 sample-addings
Motor, 58 syringe pumps, 59 sample needles, 600 needles detect thin slice, 61 injecting motors, 62 mobile motors, 63 housings, 64 flexible electricity
Machine, 65 fixed plates, 66 expansion plates, 67 handgrip components, 68 handgrip motors, 69 adjust foot.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, with reference to the accompanying drawing to the present invention
Specific embodiment be described in detail.Many details are explained in the following description in order to fully understand this hair
It is bright.But the invention can be embodied in many other ways as described herein, those skilled in the art can be not
Similar improvement is done in the case where violating intension of the present invention, therefore the present invention is not limited by the specific embodiments disclosed below.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term used in description of the invention is intended merely to describe specific embodiment party
Formula does not lie in the limitation present invention.
It is as shown in Figs. 1-2: a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument, including mainframe 1, sideslip rail 2, plus
Sample component 3 and manipulator 4,1 lower end of mainframe are equipped with bottom plate 5, and 5 lower end of bottom plate, which is equipped with, adjusts foot 69, the adjusting
Foot 69 is threadedly coupled with the bottom plate 5, and transverse plane is equipped with sample area 6, standby sample area 7 and detection zone 8 from left to right on the bottom plate 5
Three regions；The sample area 6 includes barcode scanning head 9, suction nozzle position in storehouse 10, sample bit 11, detection liquid level 12, secondary antibody work liquid level
13, liquid level 14 and run-bake-needle fault position 15 are diluted, is successively laid out the barcode scanning head 9, the suction nozzle position in storehouse from left to right in the sample area 6
10, the sample bit 11 and the secondary antibody work liquid level 13, and detection liquid level 12 is equipped on rear side of the secondary antibody work liquid level 13, described
It detects and is equipped with the run-bake-needle fault position 15 on the right side of liquid level 12, be equipped with the dilution liquid level 14 on rear side of the run-bake-needle fault position 15；The standby sample area 7
The board-washing machine 18 is located at including orifice plate position 16, incubation position 17 and board-washing machine 18, the orifice plate position 16 and the incubation position 17
Rear side, the orifice plate position 16 are set to 17 left side of incubation position, and the orifice plate position 16 is equipped with several deep-well plates 19；The incubation
Position 17 is equipped with several microplates 20, is equipped with temperature-controlling component 27 and shaking assembly inside the incubation position 17；In the board-washing machine 18
Portion also is provided with concussion component；Readout instrument 21 is equipped in the detection zone 8,21 upper end of readout instrument, which is equipped with, places the microplate 20
Microplate slot 22；It is equipped with the sideslip rail 2 in the middle part of the mainframe 1, is connected on the sideslip rail 2 by sliding block 25 and indulges sliding rail
23, it sets on the vertical sliding rail 23 there are two parallel slideway 24, the sample-adding group is clamped by sliding block 25 on one of slideway 24
Part 3 is clamped the manipulator 4 by sliding block 25 on another slideway 24.
The incubation position 17 further includes being incubated for disk 26, and 26 upper end of incubation disk is equipped with temperature-controlling component 27, the temperature control group
27 upper end of part is equipped with heat conduction aluminum pad 28, and the heat conduction aluminum pads microplate 20 described in 28 upper ends, and the lower end for being incubated for disk 26 is set
There is the shaking assembly, the shaking assembly includes vibration motor 29, vibrating shaft 30 and vibration bottom plate 31, the vibration motor 29
It is fixedly connected with the lower end of the vibrating shaft 30,30 upper end of vibrating shaft is fixedly connected with the incubation disk 26, the vibration motor
29 are fixed on the lower end of the vibration bottom plate 31, as in Figure 3-5.
The board-washing machine 18 includes shell 32, pedestal 33, coaming plate seat 34, lifting head assembly, X to motor 35 and concussion group
Part, 32 lower end of shell are fixedly connected with pedestal 33, and front side is equipped with guide rail 36 on the pedestal 33, and the lifting head assembly passes through
Sliding block 25 and guide rail 36 are clamped, and one end of the guide rail 36 is equipped with the X to motor 35, and the X passes through synchronous belt to motor 35
37 connect with the lifting head assembly, concussion component are equipped among the pedestal 33, the concussion component upper end is fixedly connected with institute
State coaming plate seat 34.The lifting head assembly include lifting motor frame 38, lifting motor 39, outer cover 40, hanging plate 41, board-washing head 42,
Board-washing needle 43,38 lower end of lifting motor frame are fixedly connected with the sliding block 25, and the sliding block 25 is clamped the guide rail 36, described
Lifting motor frame 38 is fixedly connected with the lifting motor 39, and 39 upper end of lifting motor is fixedly connected with the outer cover 40, described
The hanging plate 41 is riveted on outer cover 40 in parallel, 41 side of hanging plate connects the board-washing head 42, and 42 lower end of board-washing head is solid
Surely several board-washing needles 43 are connected, 42 side of board-washing head is equipped with connector 44.The concussion component includes concussion motor 45, vibration
Supporting plate 46, damper 47, magnetic sheet 48 and magnetic pole 49, concussion 45 upper end of motor pass through the centre of the vibration supporting plate 46, institute
The quadrangle for stating vibration 46 lower end of supporting plate is respectively fixedly connected with the upper end of the damper 47, and the lower end of the damper 47 is fixed to be connected
The pedestal 33 is connect, concussion 45 upper end of motor is fixedly connected with the centre of 48 lower end of magnetic sheet, and 48 upper end of magnetic sheet is solid
Surely several magnetic poles 49 are connected, 34 upper surface of coaming plate seat is equipped with several holes, and 49 activity of magnetic pole passes through the coaming plate seat
The hole of 34 upper surfaces, as shown in figs 6-8.
The sample-adding component 3 includes sample-adding bracket 50, sample-adding unit and adjusts motor 51, and 50 side of sample-adding bracket is logical
It crosses sliding block 25 and is connected in the slideway 24,50 other side of sample-adding bracket is equipped with guide rail 36, the guide rail of the sample-adding bracket 50
It is clamped two sample-adding units on 36, is equipped between two sample-adding units and adjusts motor 51.The sample-adding unit includes single
First fixed plate 52, unit rack 53, moving frame 54, link block, unit grillage 56, sample-adding motor 57 and syringe pump 58, it is described
Unit fixed plate 52 is clamped by sliding block 25 and the sample-adding bracket 50, and 52 other side of unit fixed plate is fixedly connected described
The side of unit rack 53 is blocked mutually between the other side and the moving frame 54 of the unit rack 53 by link block
It connects, the upper end of the unit rack 53 is fixedly connected with the sample-adding motor 57, and the sample-adding motor 57 connects synchronous belt 37, described
Synchronous belt 37 connects the link block between the unit rack 53 and the moving frame 54, and 54 lower end of moving frame is fixed
The syringe pump 58 is connected, 58 upper end of syringe pump is fixedly connected with injecting motor 61, and the injecting motor 61 passes through screw rod
The 55 connection unit grillages 56,58 lower end of syringe pump is fixedly connected with sample needle 59, is wrapped with and picks up on the outside of the sample needle 59
Needle detects thin slice 60, and needle detection 60 upper end of thin slice of picking up is fixedly connected by spring with the syringe pump 58, such as Fig. 9-10 institute
Show.
24 side of slideway that the manipulator 4 is clamped is equipped with mobile motor 62, and the manipulator 4 is equipped with link block, institute
It states mobile motor 62 to connect by synchronous belt 37 with the link block, control manipulator 4 moves in parallel, and the manipulator 4 wraps
Include housing 63, telescope motor 64, fixed plate 65, expansion plate 66, handgrip component 67 and handgrip motor 68, the fixed plate 65 and institute
The outer cup for stating expansion plate 66 has the housing 63, and 65 upper end of fixed plate is fixedly connected with the telescope motor 64, described to stretch
Contracting motor 64 connects the expansion plate 66 by screw rod 55, and 66 lower end of expansion plate is fixedly connected with the handgrip motor 68,
The handgrip motor 68 connects the handgrip component 67 by synchronous belt 37, as shown in figures 9 and 11.
A kind of application method of Full-automatic magnetic beads entry joint inspection detection analysis instrument, includes the following steps:
(1) sample identifies: the barcode scanning head 9 identifies corresponding sample bar code on the sample bit 11, obtains sample information automatically；
(2) addition sample is dilute: the sample needle 59 is moved to the installation that suction nozzle position in storehouse 10 carries out suction nozzle, installs the sample needle of suction nozzle
59, which move to the dilution liquid level 14, draws on dilution to the deep-well plates 19 in corresponding hole location, until enough hole counts are added,
Sample needle 59 is moved to the run-bake-needle fault position 15, takes off suction nozzle；
(3) diluted sample: the sample needle 59 is moved to the installation that suction nozzle position in storehouse 10 carries out suction nozzle, installs the sample needle of suction nozzle
59 move to the sample bit 11, draw sample, then move the sample needle 59 for the sample of absorption and be added to the deep-well plates
It is mixed in 19 corresponding hole locations, then draws diluted sample with the sample needle 59, then move the sample needle 59 to institute
It states and is incubated for position 17, the diluted sample of absorption is added in the hole of the microplate 20；
(4) the incubation position all sample incubation: is made by the temperature-controlling component 27 plus after diluted sample to be measured on microplate 20
17 controls at a constant temperature, are opened the shaking assembly and are shaken, and sample incubation is completed；
(5) prepare cleaning: after the completion of sample incubation, the crawl of manipulator 4 is incubated for the microplate 20 on position 17, moves to described wash
On trigger 18, concussion component opens the high speed concussion with magnetic, then switchs to middling speed concussion, stands after concussion, board-washing head 42
It is moved at the microplate 20 on board-washing machine 18, the board-washing needle 43 siphons away liquid in the hole of the microplate 20；
(6) clean: the magnetic sheet 48 moves down, and board-washing head 42 is added in the corresponding hole of the microplate 20 on board-washing machine 18
Cleaning solution, and the concussion component is opened, the magnetic sheet 48 moves up, and opens the high speed concussion with magnetic, then switchs to middling speed
Concussion, stands, board-washing head 42 is moved to the microplate 20, and the board-washing needle 43 siphons away in the hole of the microplate 20 after concussion
Liquid, one time cleaning process is completed, and is repeated 3 times cleaning process altogether；
(7) secondary antibody is incubated for: after the completion of the 3rd cleaning, the manipulator 4 grabs the microplate 20 on board-washing machine 18, and moves to institute
It states and is incubated for position 17, the sample needle 59 loads onto suction nozzle, moves to the secondary antibody work liquid level 13, draws secondary antibody working solution, add to and incubate
The corresponding hole location of the microplate 20 on position 17 is educated, to all add secondary antibody working solution on microplate 20, is made by the temperature-controlling component 27
The control of incubation position 17 at a constant temperature, is opened the shaking assembly and is shaken, and completes secondary antibody and is incubated for, and then repeats to walk
Rapid 5 and step 6；
(8) addition detection liquid: the manipulator 4 grabs the microplate 20 on board-washing machine 18 and moves to the incubation position 17, institute
It states sample needle 59 and loads onto suction nozzle, move to the detection liquid level 12 and draw detection liquid, it is corresponding to add to the microplate 20 on incubation position 17
Hole location, after the microplate 20 all plus detection liquid after, take off suction nozzle, be incubated for position 17 and open the shake at a temperature of particular constant
Dynamic component is shaken, and specific time is continued, and stops vibration；
(9) detection reading: the manipulator 4 grabs the microplate 20 on the incubation position 17, is put into micro- in the readout instrument 21
In board slot 22, the readout instrument 21 reads microplate 20, obtains testing result.
Entire detection process without human intervention, all realizes automation, and ELISA process uses magnetic bead carrier
Coated mode carries out, and detection sensitivity is high, and accuracy is high, and the preprocessing process such as dilution, incubation, cleaning of sample are whole
Automatic constant-temperature, automatic concussion may be implemented in automation, and magnetic bead carrier coating mode is avoided to detect a large amount of cumbersome manual operations.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.
Claims (10)
1. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument, which is characterized in that the detection analysis instrument includes mainframe
(1), sideslip rail (2), sample-adding component (3) and manipulator (4), mainframe (1) lower end are equipped with bottom plate (5), the bottom plate (5)
Upper transverse plane is equipped with sample area (6), standby sample area (7) and (8) three regions of detection zone from left to right；
The sample area (6) includes barcode scanning head (9), suction nozzle position in storehouse (10), sample bit (11), detection liquid level (12), secondary antibody work
Liquid level (13), dilution liquid level (14) and run-bake-needle fault position (15), the sample area (6) is interior to be successively laid out the barcode scanning head from left to right
(9), the suction nozzle position in storehouse (10), the sample bit (11) and secondary antibody work liquid level (13), the secondary antibody work liquid level
(13) rear side is equipped with detection liquid level (12), is equipped with the run-bake-needle fault position (15), the run-bake-needle fault position on the right side of the detection liquid level (12)
(15) rear side is equipped with the dilution liquid level (14)；
The standby sample area (7) includes orifice plate position (16), is incubated for position (17) and board-washing machine (18), the orifice plate position (16) and described is incubated
The rear side that position (17) is located at the board-washing machine (18) is educated, the orifice plate position (16) is set on the left of the incubation position (17), the hole
Plate position (16) is equipped with several deep-well plates (19)；The incubation position (17) is equipped with several microplates (20), the incubation position (17)
Inside is equipped with temperature-controlling component (27) and shaking assembly；Concussion component is equipped with inside the board-washing machine (18)；In the detection zone (8)
Equipped with readout instrument (21), readout instrument (21) upper end is equipped with the microplate slot (22) for placing the microplate (20)；
It is equipped with the sideslip rail (2) in the middle part of the mainframe (1), is connected on the sideslip rail (2) by sliding block (25) and indulges sliding rail
(23), it there are two being set on the vertical sliding rail (23) parallel slideway (24), is clamped on one of slideway (24) by sliding block (25)
The sample-adding component (3) is clamped the manipulator (4) by sliding block (25) on another slideway (24).
2. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 1, which is characterized in that described to incubate
Educating position (17) further includes being incubated for disk (26), and the incubation disk (26) upper end is equipped with temperature-controlling component (27), temperature control component upper end
Equipped with heat conduction aluminum pad (28), microplate (20) described in heat conduction aluminum pad (28) upper ends, the lower end for being incubated for disk (26) is set
There is the shaking assembly, the shaking assembly includes vibration motor (29), vibrating shaft (30) and vibration bottom plate (31), the vibration
Motor (29) is fixedly connected with the lower end of the vibrating shaft (30), and vibrating shaft (30) upper end is fixedly connected with the incubation disk
(26), the vibration motor (29) is fixed on the lower end of vibration bottom plate (31).
3. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 1, which is characterized in that described to wash
Trigger (18) includes shell (32), pedestal (33), coaming plate seat (34), lifting head assembly, X to motor (35) and shakes component, institute
It states shell (32) lower end to be fixedly connected pedestal (33), is equipped with guide rail (36) on front side of pedestal (33) upper end, the lift head group
Part is clamped by sliding block (25) and guide rail (36), and one end of the guide rail (36) is equipped with the X to motor (35), and the X is to electricity
Machine (35) is connect by synchronous belt (37) with the lifting head assembly, and concussion component, the shake are equipped among the pedestal (33)
It swings component upper end and is fixedly connected with the coaming plate seat (34).
4. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 3, which is characterized in that the liter
Drop head assembly includes lifting motor frame (38), lifting motor (39), outer cover (40), hanging plate (41), board-washing head (42), washes an edition needle
(43), lifting motor frame (38) lower end is fixedly connected the sliding block (25), and the sliding block (25) is clamped the guide rail (36),
The lifting motor frame (38) is fixedly connected the lifting motor (39), and lifting motor (39) upper end is fixedly connected described outer
It covers (40), is riveted in parallel the hanging plate (41) on the outer cover (40), hanging plate (41) side connects the board-washing head (42),
For the board-washing head (42) if lower end is fixedly connected with dry-cleaning version needle (43), board-washing head (42) side is equipped with connector (44).
5. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 3, which is characterized in that the shake
Swinging component includes concussion motor (45), vibration supporting plate (46), damper (47), magnetic sheet (48) and magnetic pole (49), the concussion electricity
Machine (45) upper end passes through the centre of vibration supporting plate (46), and the quadrangle of described vibration supporting plate (46) lower end is respectively fixedly connected with institute
The upper end of damper (47) is stated, the lower end of the damper (47) is fixedly connected the pedestal (33), the concussion motor (45)
Upper end is fixedly connected with the centre of the magnetic sheet (48) lower end, and magnetic sheet (48) upper end is fixedly connected several magnetic poles (49), described
Coaming plate seat (34) upper surface is equipped with several holes, and magnetic pole (49) activity passes through the hole of coaming plate seat (34) upper surface.
6. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 1, which is characterized in that described to add
Sample component (3) includes sample-adding bracket (50), sample-adding unit and adjusts motor (51), and sample-adding bracket (50) side passes through sliding block
(25) it is connected in the slideway (24), the sample-adding bracket (50) other side is equipped with guide rail (36), sample-adding bracket (50)
It is clamped two sample-adding units on guide rail (36), is equipped between two sample-adding units and adjusts motor (51).
7. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 6, which is characterized in that described to add
Sample unit includes unit fixed plate (52), unit rack (53), moving frame (54), link block, unit grillage (56), sample-adding electricity
Machine (57) and syringe pump (58), the unit fixed plate (52) is clamped by sliding block (25) and the sample-adding bracket (50), described
Unit fixed plate (52) other side is fixedly connected with the side of the unit rack (53), the other side of the unit rack (53) and
It is clamped mutually between the moving frame (54) by link block, the upper end of the unit rack (53) is fixedly connected with the sample-adding
Motor (57), the sample-adding motor (57) connect synchronous belt (37), the synchronous belt (37) connect the unit rack (53) and
Link block between the moving frame (54), moving frame (54) lower end is fixedly connected the syringe pump (58), described
Syringe pump (58) upper end is fixedly connected injecting motor (61), and the injecting motor (61) connects the unit by screw rod (55)
Grillage (56), syringe pump (58) lower end are fixedly connected sample needle (59), are wrapped on the outside of the sample needle (59) and are picked up needle detection
Thin slice (60), needle detection thin slice (60) upper end of picking up are fixedly connected by spring with the syringe pump (58).
8. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 1, which is characterized in that the machine
Slideway (24) side of tool hand (4) clamping is equipped with mobile motor (62), and manipulator (4) side is equipped with link block, the shifting
Dynamic motor (62) are connect by synchronous belt (37) with the link block, and control manipulator (4) moves in parallel, the manipulator
It (4) include housing (63), telescope motor (64), fixed plate (65), expansion plate (66), handgrip component (67) and handgrip motor
(68), the outer cup of the fixed plate (65) and the expansion plate (66) has the housing (63), the fixed plate (65) upper end
It is fixedly connected the telescope motor (64), the telescope motor (64) connects the expansion plate (66), institute by screw rod (55)
It states expansion plate (66) lower end to be fixedly connected the handgrip motor (68), the handgrip motor (68) connects institute by synchronous belt (37)
State handgrip component (67).
9. a kind of Full-automatic magnetic beads entry joint inspection detection analysis instrument according to claim 1, which is characterized in that the bottom
Plate (5) lower end, which is equipped with, adjusts foot (69), and the adjusting foot (69) is threadedly coupled with the bottom plate (5).
10. a kind of application method of Full-automatic magnetic beads entry joint inspection detection analysis instrument described in any one of claim 1-9,
It is characterized by comprising the following steps:
(1) sample identifies: the barcode scanning head (9) identifies corresponding sample bar code on the sample bit (11), obtains sample information；
(2) addition sample is dilute: the sample needle (59) is moved to the installation that suction nozzle position in storehouse (10) carry out suction nozzle, installs adding for suction nozzle
Sample needle (59) moves to the dilution liquid level (14) and draws on dilution to the deep-well plates (19) in corresponding hole location, until adding
Enough hole counts, sample needle (59) are moved to the run-bake-needle fault position (15), take off suction nozzle；
(3) diluted sample: the sample needle (59) is moved to the installation that suction nozzle position in storehouse (10) carry out suction nozzle, installs adding for suction nozzle
Sample needle (59) moves to the sample bit (11), draws sample, then moves the sample needle (59), the sample of absorption is added to
It is mixed in the corresponding hole location of the deep-well plates (19), obtains diluted sample, then draw diluted sample with the sample needle (59)
This, then moves the sample needle (59) to the incubation position (17), the diluted sample of absorption is added to the microplate (20)
Hole in；
(4) described incubate all sample incubation: is made by the temperature-controlling component (27) plus after diluted sample to be measured in microplate (20)
It educates position (17) control at a constant temperature, to open the shaking assembly and shaken, completes sample incubation；
(5) prepare cleaning: after the completion of sample incubation, manipulator (4) crawl is incubated for the microplate (20) on position (17), moves to
On the board-washing machine (18), concussion component opens the high speed concussion with magnetic, then switchs to middling speed concussion, stands after concussion,
Board-washing head (42) is moved at the microplate (20) on the board-washing machine (18), and edition needle (43) of washing siphons away the microplate (20)
Liquid in hole；
(6) clean: the magnetic sheet (48) moves down, and the board-washing head (42) is added in corresponding hole on the microplate (20)
Cleaning solution, and open the concussion component, the magnetic sheet (48) moves up, open the high speed concussion with magnetic, then switchs to
Speed concussion, stands, board-washing head (42) is moved at the microplate (20) on the board-washing machine (18), described to wash after concussion
Version needle (43) siphons away liquid in the hole of the microplate (20), and one time cleaning process is completed, and is repeated 3 times cleaning process altogether；
(7) secondary antibody is incubated for: after the completion of the 3rd cleaning, the manipulator (4) grabs the microplate (20) on the board-washing machine (18) simultaneously
The incubation position (17) is moved to, the sample needle (59) loads onto suction nozzle, moves to secondary antibody work liquid level (13), draws secondary antibody work
Make liquid, add to the corresponding hole location of the microplate (20), to all add secondary antibody working solution on microplate (20), passes through the temperature-controlling component
(27) make incubation position (17) control at a constant temperature, open the shaking assembly and shaken, complete secondary antibody and be incubated for, so
Step (5) and step (6) are repeated afterwards；
(8) addition detection liquid: the manipulator (4) grabs the microplate (20) and moves to the incubation position (17), the sample-adding
Needle (59) loads onto suction nozzle, moves to the detection liquid level (12) and draws detection liquid, the corresponding hole location of the microplate (20) is added to, to institute
State microplate (20) all plus detection liquid after, take off suction nozzle, be incubated for position (17) and open the shaking assembly at a temperature of particular constant
It is shaken, continues specific time, stop vibration；
(9) detection reading: manipulator (4) the crawl microplate (20) being incubated on position (17) is put into the readout instrument
(21) in, the readout instrument (21) reads microplate (20), obtains testing result.
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