CN109562195A - 用pd-l1结合多肽进行pet成像 - Google Patents

用pd-l1结合多肽进行pet成像 Download PDF

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Publication number
CN109562195A
CN109562195A CN201780046557.0A CN201780046557A CN109562195A CN 109562195 A CN109562195 A CN 109562195A CN 201780046557 A CN201780046557 A CN 201780046557A CN 109562195 A CN109562195 A CN 109562195A
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China
Prior art keywords
adnectin
seq
amino acid
subject
polypeptide
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Pending
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CN201780046557.0A
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English (en)
Chinese (zh)
Inventor
P·E·莫林
D·唐纳利
D·利普夫斯基
J·高科梅杰
M·尤雷-孔克尔
D·法布里奇奥
M·C·莱特
D·迪斯奇诺
S·J·博纳克斯
R·A·史密斯
V·拉丰特
D·科恩
D·K·梁
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN109562195A publication Critical patent/CN109562195A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780046557.0A 2016-06-01 2017-05-31 用pd-l1结合多肽进行pet成像 Pending CN109562195A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344258P 2016-06-01 2016-06-01
US62/344,258 2016-06-01
PCT/US2017/035227 WO2017210302A1 (en) 2016-06-01 2017-05-31 Pet imaging with pd-l1 binding polypeptides

Publications (1)

Publication Number Publication Date
CN109562195A true CN109562195A (zh) 2019-04-02

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Family Applications (1)

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CN201780046557.0A Pending CN109562195A (zh) 2016-06-01 2017-05-31 用pd-l1结合多肽进行pet成像

Country Status (6)

Country Link
US (2) US11344639B2 (https=)
EP (1) EP3463486A1 (https=)
JP (1) JP7016323B2 (https=)
KR (1) KR102397783B1 (https=)
CN (1) CN109562195A (https=)
WO (1) WO2017210302A1 (https=)

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WO2022028557A1 (zh) * 2020-08-07 2022-02-10 上海再极医药科技有限公司 18f标记的联苯类化合物、其中间体、制备方法、药物组合物及应用
CN114057589A (zh) * 2020-08-07 2022-02-18 上海再极医药科技有限公司 18f标记的联苯类化合物、其中间体、制备方法、药物组合物及应用

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CN107207379B (zh) 2014-11-25 2021-08-10 百时美施贵宝公司 用于生物制品的18f-放射性标记的方法和组合物
US10994033B2 (en) 2016-06-01 2021-05-04 Bristol-Myers Squibb Company Imaging methods using 18F-radiolabeled biologics
JP7016323B2 (ja) 2016-06-01 2022-02-21 ブリストル－マイヤーズ スクイブ カンパニー Ｐｄ－ｌ１結合ポリペプチドを用いるｐｅｔ造影
CN110914302A (zh) 2017-06-01 2020-03-24 赛托姆克斯治疗学股份有限公司 可活化抗pdl1抗体及其使用方法
WO2019165143A1 (en) * 2018-02-21 2019-08-29 Cytomx Therapeutics, Inc. Positron emission tomography imaging of activatable binding polypeptides and related compositions thereof
EP3818085A4 (en) 2018-06-01 2022-03-09 Tayu Huaxia Biotech Medical Group Co., Ltd. COMPOSITIONS AND THEIR USES FOR THE TREATMENT OF DISEASES OR DISORDERS
WO2019227490A1 (en) * 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
CN113795511B (zh) 2019-01-23 2024-07-23 大有华夏生物医药集团有限公司 抗pd-l1双抗体及其用途
CN110746493A (zh) * 2019-09-06 2020-02-04 中国药科大学 一种pd-l1拮抗剂多肽及其应用
WO2021174045A1 (en) 2020-02-28 2021-09-02 Bristol-Myers Squibb Company Radiolabeled fibronectin based scaffolds and antibodies and theranostic uses thereof
CN115916262A (zh) * 2020-04-21 2023-04-04 旗舰创业股份有限公司 双官能分子及其使用方法
US20250135047A1 (en) * 2021-08-06 2025-05-01 The Johns Hopkins University Improved aluminum fluoride radiosynthesis of [18f]dk222

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CN111116595A (zh) * 2019-12-30 2020-05-08 福建医科大学附属第一医院 以tspo为靶点的放射性分子探针及其制备方法和应用
WO2022028557A1 (zh) * 2020-08-07 2022-02-10 上海再极医药科技有限公司 18f标记的联苯类化合物、其中间体、制备方法、药物组合物及应用
CN114057589A (zh) * 2020-08-07 2022-02-18 上海再极医药科技有限公司 18f标记的联苯类化合物、其中间体、制备方法、药物组合物及应用

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JP7016323B2 (ja) 2022-02-21
JP2019525891A (ja) 2019-09-12
KR20190015376A (ko) 2019-02-13
EP3463486A1 (en) 2019-04-10
WO2017210302A1 (en) 2017-12-07
US20190184042A1 (en) 2019-06-20
US11344639B2 (en) 2022-05-31
US20220347324A1 (en) 2022-11-03
KR102397783B1 (ko) 2022-05-12

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