CN109528899A - Radix bupleuri massage oil, preparation method and its application - Google Patents
Radix bupleuri massage oil, preparation method and its application Download PDFInfo
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The embodiment of the invention discloses a kind of radix bupleuri massage oil, preparation method and its applications.Wherein, the radix bupleuri massage oil includes following ingredient: substrate oil, radix bupleuri, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot.The radix bupleuri massage oil can enable radix bupleuri by way of massaging essential oil, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, and the effective ingredient of sweet wormwood and bergamot can be absorbed by the human body via skin and smell and reach good health care and medical effect.Since the mode of massage essential oil does not need the absorption by gastrointestinal tract, the intake of harmful toxic matter and the control of essential oil quality can be avoided very well.Moreover, the effective component of chinese medicine of radix bupleuri massage oil addition has nourishing the liver, liver soothing and depression relief, pressure of relaxing, the good effects of wide chest relieve stagnation etc., suitable for sub-health population, such as the excessive person of poor sleeping quality, tobacco and wine.
Description
Technical field
The present invention relates to health product technology field more particularly to a kind of radix bupleuri massage oils, preparation method and its application.
Background technique
Traditional Chinese medicine compound preparation enables the water soluble compound in a variety of drugs by high temperature etc. usually in a manner of boiling repeatedly etc.
After processing, be dissolved in the water or solvent that other are different in so that preparation can enter human body by way of oral,
Be absorbed by the body and reach health or health care and other effects.
But existing Chinese medicine material much all contains the harmful toxicants such as plasticiser, heavy metal, pesticide residue, no
It is preferably taken and absorbs by human body.The solvent introduced in the manufacturing process of some Chinese materia medica preparations may also pollute, the medicine of Chinese medicine
Reason characteristic may be difficult to be embodied as, and the quality of Chinese materia medica preparation is unable to get good control.
Therefore, there is an urgent need to provide a kind of new Chinese medicine method of application, preferably to play the health care of Chinese medicine
Effect.
Summary of the invention
In view of the above technical problems, the embodiment of the invention provides a kind of radix bupleuri massage oil, preparation method and its application,
It is not easy to manage to solve the problem of that the pharmacological action of present traditional Chinese medicine preparation is not easy to embody product quality.
The first aspect of the embodiment of the present invention provides a kind of radix bupleuri massage oil.Wherein, the radix bupleuri massage oil includes as follows
Ingredient: substrate oil, radix bupleuri, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot.
Optionally, the substrate oil is mixed to form by Sweet Almond Oil and SIMMONDSIA CHINENSIS SEED OIL with 3 to 2 ratio.
Optionally, the radix bupleuri massage oil is by radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, blueness
Wormwood artemisia extract and bergamot extract press preset adding proportion and mix acquisition with the substrate oil.
Optionally, the radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract and
The adding proportion of bergamot extract is 2:1:1:1:1:6.
Optionally, by weight, in every 100g substrate oil, it is added with following ingredient:
The second aspect of the embodiment of the present invention additionally provides the preparation method of radix bupleuri massage oil as described above.Wherein, institute
Stating preparation method includes:
Pre-process radix bupleuri, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot raw material；
By ultrahigh speed vacuum hydro-extraction method, the radix bupleuri is extracted, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, in sweet wormwood and bergamot raw material
Active drug ingredient, obtain corresponding radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extraction
Object and bergamot extract；
By the radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract and fingered citron
Mandarin orange extract is added in substrate oil by preset ratio, obtains the radix bupleuri massage oil.
Optionally, the ultrahigh speed vacuum hydro-extraction method includes:
In the case where being higher than critical-temperature and pressure, compression fluid is to form supercritical fluid；
Use the active drug ingredient of the supercritical fluid extraction raw material；
Pressure and temperature is all restored to normal temperature and pressure, so that active drug ingredient is separated with gaseous fluid.
Optionally, the substrate oil is the high volatile oily liquids that Sweet Almond Oil and SIMMONDSIA CHINENSIS SEED OIL form.
Optionally, the method also includes: detect whether the radix bupleuri massage oil accords with by high performance liquid chromatography chromatography
Close preset quality standard.
The third aspect of the embodiment of the present invention additionally provides application of the radix bupleuri massage oil in point massage.
In technical solution provided in an embodiment of the present invention, by the way that Chinese medicine composition is made as the shape that radix bupleuri massages essential oil
Formula can enable the effective ingredient in component formula that can be absorbed by the human body via skin and smell, reach good guarantor
Strong and medical effect.
Such mode does not need the absorption by gastrointestinal tract, avoids the intake risk of harmful toxic matter, and can be effective
Quality control is realized by the methods of high performance liquid chromatography.
Moreover, the radix bupleuri massage oil has nourishing the liver, liver soothing and depression relief, pressure of relaxing, the good effects of wide chest relieve stagnation etc..With massage etc.
Mode can obtain extraordinary health-care effect after being applied to sub-health population (such as poor sleeping quality, tobacco and wine are excessive), improve
Illness.
Detailed description of the invention
Fig. 1 is one embodiment schematic diagram of the preparation method of radix bupleuri massage oil provided in an embodiment of the present invention；
Fig. 2 is one embodiment schematic diagram of ultrahigh speed vacuum hydro-extraction equipment provided in an embodiment of the present invention；
Fig. 3 is one embodiment schematic diagram of human acupoint provided in an embodiment of the present invention distribution.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those skilled in the art's every other implementation obtained without creative efforts
Example, shall fall within the protection scope of the present invention.
It should be noted that be expressed " being fixed on " another element when element, it can directly on the other element,
Or there may be one or more elements placed in the middle therebetween.When an element is expressed " connection " another element, it can be with
It is directly to another element or there may be one or more elements placed in the middle therebetween.Used in this specification
The orientation or position of the instructions such as term "vertical", "horizontal", "left" and "right", "upper", "lower", "inner", "outside", " bottom "
Relationship is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description of the present invention and simplification of the description, without referring to
Show or imply that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore cannot manage
Solution is limitation of the present invention.In addition, term " first ", " second " etc. are used for description purposes only, and should not be understood as instruction or
Imply relative importance.
Unless otherwise defined, technical and scientific term all used in this specification is led with technology of the invention is belonged to
The normally understood meaning of the technical staff in domain is identical.Used term is only in the description of the invention in this specification
The purpose of description specific embodiment is not intended to the limitation present invention.Term "and/or" used in this specification includes
Any and all combinations of one or more related listed items.In addition, invention described below difference is implemented
Technical characteristic involved in mode can be combined with each other as long as they do not conflict with each other.
The embodiment of the invention provides a kind of radix bupleuri massage oils.Wherein, the radix bupleuri massage oil includes following ingredient: substrate
Oil, radix bupleuri, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot.
Substrate oil is the oily liquids with high volatile, the basis as entire massage essential oil.Specifically, it can be by
Sweet Almond Oil and SIMMONDSIA CHINENSIS SEED OIL are mixed according to 3 to 2 ratio.SIMMONDSIA CHINENSIS SEED OIL be from Jojoba (Jojoba, also known as flash
Bar, a kind of plant that Mexico is primary) in extraction obtain oil.The arrangement of its chemical molecular is very similar with the sebum of the mankind, belongs to
Wax quality and on-liquid quality, are easy in by skin and absorption.
After substrate oil is added with other active drug ingredients, it can have nourishing the liver when using as massage essential oil, dredge
Liver relieve stagnation, pressure of relaxing, the effect of wide chest relieve stagnation etc..It can apply the efficacy of a drug by modes such as massages, be suitable for insomnia, sleep quality
Bad, fatigue is felt dizzy, the big person of operating pressure, physical psychological person, the body psychology of sub-health population can be helped to be metabolized negative
Energy circulation.
In some embodiments, the active drug ingredient of above-mentioned radix bupleuri massage oil is added in the form of extract, mainly
It is pressed by radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract and bergamot extract
Preset adding proportion mixes acquisition with the substrate oil.Manufactured radix bupleuri massage oil, which can be closed, to be kept in dark place in vial etc.
In container.
Preferably, the preset adding proportion specifically may is that radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, river
Rhizome of chuanxiong extract, sweet wormwood extract and bergamot extract are 2:1:1:1:1:6.
Specifically, be adapted with above-mentioned adding proportion, it by weight, can be in every 100g substrate oil added with as follows
Ingredient is to obtain the radix bupleuri massage oil:
For the quality for guaranteeing massage oil, the influence of harmful toxic matter is avoided, the radix bupleuri massage oil is in factory before use, can be with
It is detected by the methods of gas-chromatography and mass spectral analysis, determines whether objectionable impurities content is detected or whether can accord with
Preset safety standard is closed, to effectively ensure the quality of radix bupleuri massage oil.
In the actual use process of radix bupleuri massage oil, as shown in figure 3, the bavin can be used in masseur or support staff
Hu massage oil massages neck and shoulder part (including cervical vertebra backbone center point Fengfu to the Dazhui acupoint and bladder passages through which vital energy circulates between thoracic vertebrae, the gallbladder of shoulder
Through, shoulder neck cave), side of body rib portion and reinforce massage along point lr 13 and point lr 14 and the Liver Channel arteries and veins of leg.
Clinical real example:
Based on the usage mode of above radix bupleuri massage oil, using radix bupleuri massage oil provided in an embodiment of the present invention to 100
Position have chest side of body overflow, belch, bitter taste halitosis, scalp is fuel-displaced, scalp pruritus, temples white hair is early raw, often smokes and drink and skin
After the user of the ill symptoms such as skin itching carries out health care massage treatment 1 month, the feedback information discovery of user is counted:
Many ill symptoms have all obtained different degrees of improvement, wherein the user's quantity improved according to illness
The percentage of all user's numbers is accounted for calculate, eliminate fatigue 89%, irritability agitation 70%, shoulder neck aches 85%, flatulence
80%, scalp fuel-displaced 60%, bitter taste 70%.
Tradition usually has water boiling method, infusion process, diacolation for the extracting method of the effective component in Traditional Chinese medicine raw material
Method, Gelatin improving method, circumfluence method and solvent extraction method etc. are several.
For example, solvent extraction method is most widely used method.Its principle is molten according to effective components various in Chinese herbal medicine
The property of Xie Du, is selected to needing ingredient solubility big and the solvent small to other compositions solubility, by required activity at
Divide and is extracted out of medicinal material tissue.
Steam distillation rule is can be with steam distillation, without the one kind being destroyed using the effective component in Chinese medicine
Extracting method.Its extraction for being mainly used for aqua aromatica and volatile oil.The principle of this method is dalton principle --- it is mutually insoluble
Also the steam stagnation pressure of chemically inert liquid mixture, equal to the sum of the saturation pressure of each component at this temperature.It is such, to the greatest extent
The boiling point of pipe each component itself is higher than the boiling point of mixed liquor, but when dividing summation equal to atmospheric pressure, liquid mixture starts
It boils and is distilled off.
Based on one or more kinds of defects or deficiency present in these traditional extracting methods, the embodiment of the present invention
Second aspect additionally provides the preparation method of radix bupleuri massage oil as described above.Fig. 1 is preparation side provided in an embodiment of the present invention
The method schematic diagram of method.Fig. 2 is the structural schematic diagram of Preparation equipment provided in an embodiment of the present invention.Based on Fig. 1 and shown in Fig. 2
Preparation method can provide better raw material abstraction efficiency.As depicted in figs. 1 and 2, may include following specific steps:
100, radix bupleuri, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot raw material are pre-processed.
The preprocessing process specifically can be it is any, for the treatment process of Chinese medicine material, such as to Chinese medicine principle
Cleaning is broken to reduce volume etc..
200, by ultrahigh speed vacuum hydro-extraction method, the radix bupleuri is extracted, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot are former
Active drug ingredient in material obtains corresponding radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood
Extract and bergamot extract.
As shown in Fig. 2, the extraction equipment include: oil pressure cylinder 11, vacuum shell 12, glass visit window 13, cooling device 14,
Distilled water storage barrel 15, cooling water radiator 16, revolution pumping 17 and vacuum pump 18.
The extraction process of its ultrahigh speed vacuum hydro-extraction method approximately as: firstly, inside vacuum shell 12 carry out low temperature thickening
With the process of low temperature distillation (glass visits window can be to observe the treatment process of raw material) so that effective medicine of traditional Chinese medicinal material raw materials
Object ingredient is substantially dissolved in shooting flow body.Then, pressure and temperature is all restored to normal temperature and pressure, enables supercritical fluid extensive
It is again gaseous fluid, so that being dissolved in active drug ingredient therein and gaseous fluid quick separating, realizes finally for effective
The extraction operation of ingredient.
300, by the radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract and
Bergamot extract is added in substrate oil by preset ratio, obtains the radix bupleuri massage oil.
Specifically, the substrate oil is the high volatile oily liquids that Sweet Almond Oil and SIMMONDSIA CHINENSIS SEED OIL form.It can be adopted
It is mixed and is formed with suitable ratio, such as in every 100g substrate oil, including 60g Sweet Almond Oil and 40g SIMMONDSIA CHINENSIS SEED OIL.
Preferably, it is also necessary to which detecting the radix bupleuri massage oil using high performance liquid chromatography chromatography (HPLC) whether there is
Excessive harmful substance.If then abandoning and remaking, to ensure that the radix bupleuri massage oil can be by the use of safety.
Specifically, needing detected harmful substance includes following some projects: organic phosphorus and Carbamates agriculture
Medicine residual, borax, formaldehyde, sulfur dioxide, hydrogen peroxide, nitrite, nitrate, sodium formaldehyde sulfoxylate, protein and heavy metal lead.
Certainly, which can also further roll over coloration, rotation brightness, specific gravity, oily oxidant survey after testing
The detection such as examination is to ensure the quality of essential oil and meet the standard detection project of inlet and outlet COA.
In conclusion the radix bupleuri massage essential oil provided through the embodiment of the present invention, by Chinese medicine active drug ingredient and west
Essential oil collocation application, can make effective ingredient become completing by skin and smell by the mode that stomach absorbs, can
To have very good health-care effect, it is not easy to the excessively intake such as harmful substances such as heavy metal occur and be also convenient for Control platform.
In addition, the compatibility of a variety of Chinese medicine composition, can be very good to improve insomnia, sleep quality is bad, fatigue, dizzy brain
Swollen, operating pressure is greatly and the illness of physical psychological person, help eliminate body psychology metabolism negative energy circulation, has good guarantor
Strong effect.
It, can according to the technique and scheme of the present invention and this hair it is understood that for those of ordinary skills
Bright design is subject to equivalent substitution or change, and all these changes or replacement all should belong to the guarantor of appended claims of the invention
Protect range.
Claims (10)
1. a kind of radix bupleuri massage oil, which is characterized in that the radix bupleuri massage oil includes following ingredient: substrate oil, radix bupleuri, Radix Astragali,
Rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot.
2. radix bupleuri massage oil according to claim 1, which is characterized in that by weight calculating, the substrate oil is by sweet tea apricot
Benevolence oil and SIMMONDSIA CHINENSIS SEED OIL are mixed to form with 3 to 2 ratio.
3. radix bupleuri massage oil according to claim 1, which is characterized in that the radix bupleuri massage oil is by radix bupleuri extract, Huang
Stilbene extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract and bergamot extract press preset adding proportion and institute
The mixing of substrate oil is stated to obtain.
4. radix bupleuri massage oil according to claim 3, which is characterized in that the radix bupleuri extract, Radix Astragali extract, rhizoma cyperi
Extract, Rhizoma Chuanxiong extract, sweet wormwood extract and bergamot extract adding proportion be 2:1:1:1:1:6.
5. radix bupleuri massage oil according to claim 4, which is characterized in that by weight, in every 100g substrate oil, addition
There is following ingredient:
6. a kind of preparation method of radix bupleuri massage oil, which is characterized in that the preparation method includes:
Pre-process radix bupleuri, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, sweet wormwood and bergamot raw material；
By ultrahigh speed vacuum hydro-extraction method, the radix bupleuri is extracted, Radix Astragali, rhizoma cyperi, Rhizoma Chuanxiong, having in sweet wormwood and bergamot raw material
Imitate drug ingedient, obtain corresponding radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract with
And bergamot extract；
By the radix bupleuri extract, Radix Astragali extract, rhizoma cyperi extract, Rhizoma Chuanxiong extract, sweet wormwood extract and bergamot extraction
It takes object to be added in substrate oil by preset ratio, obtains the radix bupleuri massage oil.
7. preparation method according to claim 6, which is characterized in that the ultrahigh speed vacuum hydro-extraction method includes:
In the case where being higher than critical-temperature and pressure, compression fluid is to form supercritical fluid；
Use the active drug ingredient of the supercritical fluid extraction raw material；
Pressure and temperature is all restored to normal temperature and pressure, so that the active drug ingredient is separated with gaseous fluid.
8. preparation method according to claim 6, which is characterized in that the substrate oil is Sweet Almond Oil and SIMMONDSIA CHINENSIS SEED OIL group
At high volatile oily liquids.
9. preparation method according to claim 6, which is characterized in that the method also includes: pass through high performance liquid chromatography
Chromatography detects whether the radix bupleuri massage oil meets preset quality standard.
10. application of the radix bupleuri massage oil a method as claimed in any one of claims 1 to 5 in point massage.
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