CN108498768A - A kind of external application promoting blood circulation and pain relieve composition - Google Patents
A kind of external application promoting blood circulation and pain relieve composition Download PDFInfo
- Publication number
- CN108498768A CN108498768A CN201810416858.4A CN201810416858A CN108498768A CN 108498768 A CN108498768 A CN 108498768A CN 201810416858 A CN201810416858 A CN 201810416858A CN 108498768 A CN108498768 A CN 108498768A
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- oil
- radix
- pain
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Abstract
The invention belongs to the technical field of compositions that relieves the pain, and in particular to a kind of external application promoting blood circulation and pain relieve composition is made of following component and percent by volume：Safflower oil 40 70%, Japan cypress oil 30 55%, tea oil 5 10%, oil of juniper wood 20 40% and B component essential oil 5 15%.A kind of external application promoting blood circulation and pain relieve composition disclosed by the invention derives from pure plant, and nontoxic, preparation process is simple.
Description
Technical field
The present invention relates to a kind of external application promoting blood circulation and pain relieve compositions.Belong to the technical field that relieves the pain.
Background technology
Traditional Chinese medicine also has various features in the dosage form of drug, such as inner disease outer treat is unexpected with regard to often obtaining
Good effect.Aromatotherapy is sucked, massages and is absorbed to that can be summarized as three kinds with the application method of Chinese medicine drug composition.Sucking
It is that Chinese medicine drug composition is made to enter the most fast method of human body, fragrant plant Chinese medicine drug composition molecule is sucked by nasal cavity, is made
Chinese medicine drug composition molecule passes to the nasal epithelium being made of olfactory cell on nasal cavity top by nasal meatus from throat rear portion, remakes use
To the olfactory area of brain, the release of neurochemical is inspired, then sends out instruction via brain centres nerve, goes regulation and control peace
Weigh automatic nervous system, to which generation calms, loosens, pleasant or excited effect.Massage is one of the most comfortable in aromatotherapy
Kind therapy.Since the structure of Chinese medicine drug composition molecule is smaller, easily skin permeation, massage can help Chinese medicine drug composition molecule
It penetrates into vivo, accelerates to absorb, keep body and mind loose, while maintaining skin, and the active blood of energy, promote Lymphatic Circulation, enhancing
Immunity.Intake refers to that Chinese medicine drug composition is directly used in affected part, such as cleaning, anti-inflammatory and the reparation of scar of wound
Deng.It sucks and massages in use and is relatively common.
There have been the history of some time in foreign countries with aromatotherapy, the most notable, Chinese medicine the effect of for nervous system
Drug composition can make one to mind at rest, and mitigate melancholy, uneasy and anxiety mood, also have for dispelling fatigue and relieving insomnia
Certain effects, while spirit can also be inhibited to be overexcited, help to focus on, enhance memory and other effects, helps to delay
Solve anxiety disorder.
We are guidance with traditional Chinese medicine theory, and the document of analysis and the relevant Medicine and Surgery disease of anxiety disorder is used for reference ancient
The clinical practice experience of modern doctor, and newest bio-pharmaceuticals engineering technology both at home and abroad, being prepared into one kind can be invigorated blood circulation with external application
Relieve the pain composition.
Invention content
The present invention proposes a kind of external application promoting blood circulation and pain relieve composition, and by many experiments screening, environmental protection is without side-effects,
It is notable to pain palliation efficacy, solve problems of the prior art.
In order to solve the above-mentioned technical problem, the technical scheme is that：
A kind of external application promoting blood circulation and pain relieve composition, is made of following component and percent by volume：Safflower oil 40-70%, Japan cypress
Oily 30-55%, tea oil 5-10%, pinke needle oil 20-40%, oil of juniper wood 20-40% and B component essential oil 5-15%；
The B component essential oil is the supercritical extract of following weight parts component：
5 parts of lopseed, 4 parts of the root of Dahurain angelica, 12 parts of fennel seeds, 7 parts of cloves, 5 parts of Radix Angelicae Sinensis, 2 parts of west safflower, 9 parts of rhizoma zingiberis, rhizoma cyperi 13
Part, 5 parts of cassia twig, 11 parts of folium artemisiae argyi, 13 parts of RADIX CURCUMAE, 2 parts of frankincense, 2 parts of myrrh, 3 parts of kamuning, 4 parts of Radix Salviae Miltiorrhizae, 5 parts of the root of Chinese clematis, bavin
10 parts recklessly, 5 parts of Radix Codonopsis, 5 parts of fingered citron, 6 parts of Radix Ophiopogonis, 5 parts of Radix Astragali, 15 parts of lycopodium calvatum, Psoralen grass 15 parts, 10 parts of Rhizoma Atractylodis Macrocephalae, smilax 5
Part, 4 parts of pawpaw, 3 parts of Curcuma wenyujin, 5 parts of Semen Cuscutae, 10 parts of pueraria lobata, 7 parts of Caulis Spatholobi, 8 parts of cacumen biotae, 5 parts of Rhizoma Et Radix Notopterygii, frutus cnidii 15
Part, 12 parts of the fruit of summer cypress, 10 parts of coix seed, 5 parts of dried rehamnnia root, 10 parts of trigone, 6 parts windproof, 8 parts of 5 parts of drooping stringbush flower root and bark and Chinese prickly ash；
The supercritical extraction method of the B component essential oil is：Raw material crush, and cross 40-60 mesh sieve, coordinate in parts by weight
And mixing；It is packed into extraction kettle, the parameters of extraction kettle, separating still, heating apparatus and the normal work of refrigerating plant are debugged in sealing
Make, opens compression pump and be pressurised into 21-22Mpa, pumping liquid C02Plants essential oil is extracted, extract is parsed from separating still, obtains B
Component essential oil.
The present invention has the characteristics that following and advantageous effect：
B component essential oil is by plurality of Chinese mixture in proportion in a kind of external application promoting blood circulation and pain relieve composition of the present invention
Supercritical extract.Safflower oil, Japan cypress oil, external application promoting blood circulation and pain relieve made of mixture combines in proportion for oil of juniper wood and B component essential oil
Object can be as the externally applied drug of promoting blood circulation and pain relieve.External application promoting blood circulation and pain relieve composition derives from pure plant, nontoxic, preparation process
Simply, there is good promoting blood circulation to remove blood stasis, the benefits of relieving the pain through dredging collateral, detumescence of relaxing.
Specific implementation mode
The specific implementation mode of the present invention is described further below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but does not constitute limitation of the invention.In addition, invention described below
Involved technical characteristic can be combined with each other as long as they do not conflict with each other in each embodiment.
Embodiment 1：
The preparation of B component essential oil：By 5 parts of lopseed, 4 parts of the root of Dahurain angelica, 12 parts of fennel seeds, 7 parts of cloves, 5 parts of Radix Angelicae Sinensis, west safflower
2 parts, it is 9 parts of rhizoma zingiberis, 13 parts of rhizoma cyperi, 5 parts of cassia twig, 11 parts of folium artemisiae argyi, 13 parts of RADIX CURCUMAE, 2 parts of frankincense, 2 parts of myrrh, 3 parts of kamuning, red
4 parts of ginseng, 5 parts of the root of Chinese clematis, 10 parts of radix bupleuri, 5 parts of Radix Codonopsis, 5 parts of fingered citron, 6 parts of Radix Ophiopogonis, 5 parts of Radix Astragali, 15 parts of lycopodium calvatum, Psoralen grass 15
Part, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of smilax, 4 parts of pawpaw, 3 parts of Curcuma wenyujin, 5 parts of Semen Cuscutae, 10 parts of pueraria lobata, 7 parts of Caulis Spatholobi, cacumen biotae 8
Part, 5 parts of Rhizoma Et Radix Notopterygii, 15 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 10 parts of coix seed, 5 parts of dried rehamnnia root, 10 parts of trigone, 6 parts windproof, drooping stringbush flower root and bark
5 parts uniformly mixed with 8 parts of Chinese prickly ash, crosses 40-60 mesh sieve, matches merging mixing in parts by weight；It is packed into extraction kettle, sealing, debugging extraction
The parameters of kettle, separating still, heating apparatus and refrigerating plant normal work are taken to open compression pump and be pressurised into 21-22Mpa, pump
Enter liquid C02Plants essential oil is extracted, extract is parsed from separating still, obtains B component essential oil.
The preparation of external application promoting blood circulation and pain relieve composition：Safflower oil 40%, Japan cypress oil 30%, tea oil 5-10%, pinke needle oil 20-
40%, oil of juniper wood 20% and B component essential oil 5%, by percent by volume addition and mixing to obtain the final product.
Embodiment 2
The preparation of B component essential oil：By 5 parts of lopseed, 4 parts of the root of Dahurain angelica, 12 parts of fennel seeds, 7 parts of cloves, 5 parts of Radix Angelicae Sinensis, west safflower
2 parts, it is 9 parts of rhizoma zingiberis, 13 parts of rhizoma cyperi, 5 parts of cassia twig, 11 parts of folium artemisiae argyi, 13 parts of RADIX CURCUMAE, 2 parts of frankincense, 2 parts of myrrh, 3 parts of kamuning, red
4 parts of ginseng, 5 parts of the root of Chinese clematis, 10 parts of radix bupleuri, 5 parts of Radix Codonopsis, 5 parts of fingered citron, 6 parts of Radix Ophiopogonis, 5 parts of Radix Astragali, 15 parts of lycopodium calvatum, Psoralen grass 15
Part, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of smilax, 4 parts of pawpaw, 3 parts of Curcuma wenyujin, 5 parts of Semen Cuscutae, 10 parts of pueraria lobata, 7 parts of Caulis Spatholobi, cacumen biotae 8
Part, 5 parts of Rhizoma Et Radix Notopterygii, 15 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 10 parts of coix seed, 5 parts of dried rehamnnia root, 10 parts of trigone, 6 parts windproof, drooping stringbush flower root and bark
5 parts uniformly mixed with 8 parts of Chinese prickly ash, crosses 40-60 mesh sieve, matches merging mixing in parts by weight；It is packed into extraction kettle, sealing, debugging extraction
The parameters of kettle, separating still, heating apparatus and refrigerating plant normal work are taken to open compression pump and be pressurised into 21-22Mpa, pump
Enter liquid C02Plants essential oil is extracted, extract is parsed from separating still, obtains B component essential oil.
The preparation of external application promoting blood circulation and pain relieve composition：Safflower oil 70%, Japan cypress oil 55%, tea oil 5-10%, pinke needle oil 20-
40%, oil of juniper wood 40% and B component essential oil 15%, by percent by volume addition and mixing to obtain the final product.
Embodiment 3：
The preparation of B component essential oil：By 5 parts of lopseed, 4 parts of the root of Dahurain angelica, 12 parts of fennel seeds, 7 parts of cloves, 5 parts of Radix Angelicae Sinensis, west safflower
2 parts, it is 9 parts of rhizoma zingiberis, 13 parts of rhizoma cyperi, 5 parts of cassia twig, 11 parts of folium artemisiae argyi, 13 parts of RADIX CURCUMAE, 2 parts of frankincense, 2 parts of myrrh, 3 parts of kamuning, red
4 parts of ginseng, 5 parts of the root of Chinese clematis, 10 parts of radix bupleuri, 5 parts of Radix Codonopsis, 5 parts of fingered citron, 6 parts of Radix Ophiopogonis, 5 parts of Radix Astragali, 15 parts of lycopodium calvatum, Psoralen grass 15
Part, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of smilax, 4 parts of pawpaw, 3 parts of Curcuma wenyujin, 5 parts of Semen Cuscutae, 10 parts of pueraria lobata, 7 parts of Caulis Spatholobi, cacumen biotae 8
Part, 5 parts of Rhizoma Et Radix Notopterygii, 15 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 10 parts of coix seed, 5 parts of dried rehamnnia root, 10 parts of trigone, 6 parts windproof, drooping stringbush flower root and bark
5 parts uniformly mixed with 8 parts of Chinese prickly ash, crosses 40-60 mesh sieve, matches merging mixing in parts by weight；It is packed into extraction kettle, sealing, debugging extraction
The parameters of kettle, separating still, heating apparatus and refrigerating plant normal work are taken to open compression pump and be pressurised into 21-22Mpa, pump
Enter liquid C02Plants essential oil is extracted, extract is parsed from separating still, obtains B component essential oil.
The preparation of external application promoting blood circulation and pain relieve composition：Safflower oil 50%, Japan cypress oil 40%, tea oil 5-10%, pinke needle oil 20-
40%, oil of juniper wood 30% and B component essential oil 8%, by percent by volume addition and mixing to obtain the final product.
Embodiment 4：
The preparation of B component essential oil：By 5 parts of lopseed, 4 parts of the root of Dahurain angelica, 12 parts of fennel seeds, 7 parts of cloves, 5 parts of Radix Angelicae Sinensis, west safflower
2 parts, it is 9 parts of rhizoma zingiberis, 13 parts of rhizoma cyperi, 5 parts of cassia twig, 11 parts of folium artemisiae argyi, 13 parts of RADIX CURCUMAE, 2 parts of frankincense, 2 parts of myrrh, 3 parts of kamuning, red
4 parts of ginseng, 5 parts of the root of Chinese clematis, 10 parts of radix bupleuri, 5 parts of Radix Codonopsis, 5 parts of fingered citron, 6 parts of Radix Ophiopogonis, 5 parts of Radix Astragali, 15 parts of lycopodium calvatum, Psoralen grass 15
Part, 10 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of smilax, 4 parts of pawpaw, 3 parts of Curcuma wenyujin, 5 parts of Semen Cuscutae, 10 parts of pueraria lobata, 7 parts of Caulis Spatholobi, cacumen biotae 8
Part, 5 parts of Rhizoma Et Radix Notopterygii, 15 parts of frutus cnidii, 12 parts of the fruit of summer cypress, 10 parts of coix seed, 5 parts of dried rehamnnia root, 10 parts of trigone, 6 parts windproof, drooping stringbush flower root and bark
5 parts uniformly mixed with 8 parts of Chinese prickly ash, crosses 40-60 mesh sieve, matches merging mixing in parts by weight；It is packed into extraction kettle, sealing, debugging extraction
The parameters of kettle, separating still, heating apparatus and refrigerating plant normal work are taken to open compression pump and be pressurised into 21-22Mpa, pump
Enter liquid C02Plants essential oil is extracted, extract is parsed from separating still, obtains B component essential oil.
The preparation of external application promoting blood circulation and pain relieve composition：Safflower oil 55%, Japan cypress oil 32%, tea oil 5-10%, pinke needle oil 20-
40%, oil of juniper wood 38% and B component essential oil 13%, by percent by volume addition and mixing to obtain the final product.
Embodiment 5：
Embodiment 1 investigates the safety of skin：Including animal skin acute toxicity test, skin irritation test and skin
Skin hypersensitive test.
Experiment material：Experimental animal new zealand rabbit, regular grade, weight (2.0 ± 0.2) kg, male and female dual-purpose.Cavy, weight
250~300g male and female dual-purposes, are provided by Experimental Animal Center.
Experimental method and result：
Skin sensibiligen tests the new zealand rabbit 20 for taking weight (2.0 ± 0.2) kg, half male and half female, before administration
For 24 hours, by back backbone both sides unhairing, every is removed gross area about 150cm2(about the 10% of body surface area).It is divided into 5 groups, every group 4
Only, control group every applies physiological saline lml；Each two groups of high low dose group (being respectively intact skin group and damaged skin group).Its
Skin of unhairing is sterilized and is scratched with needle by middle damaged skin.It is degree with oozing of blood.The outer of embodiment 1 is coated on experimental group skin of unhairing
With promoting blood circulation and pain relieve composition, the external application promoting blood circulation and pain relieve composition 2.0ml of every painting embodiment 1 of low dose group, high dose group every
The external application promoting blood circulation and pain relieve composition 4.0ml for applying embodiment 1, is uniformly applied to hair removal section, nonirritant gauze, immobilization with adhesive tape is used in combination,
Sub-cage rearing, administration for 24 hours after, left drug is removed with warm water, remove drug after 1,24,48,72h to the 7th days, observe rabbit
Situations such as weight, skin, hair, eye, mucous membrane and breathing, activity, it is showed no exception, no death does not have bright compared with the control group
Significant difference is different.I.e. the external application promoting blood circulation and pain relieve composition of embodiment 1 prompts actual use peace to new zealand rabbit skin sensibiligen very little
Entirely.
Skin irritation test takes weight (2.0 ± 0.2) kg new zealand rabbits 20, half male and half female before administration for 24 hours will
Back backbone both sides unhairing, every is removed gross area about 3cm × 3cm.Using androgynous left and right sides Self-control method, it is divided into two groups, often
Group 4, completely group and skin injury group, rabbit right side apply physiological saline 1ml to skin, and the external application promoting blood circulation that left side applies embodiment 1 stops
Ache composition 2.0ml.Skin of unhairing is sterilized and is scratched with needle by skin injury group, is degree with oozing of blood.After coating, with two layers of gauze
2.5cm × 2.5cm and one layer of glassine paper covering, then fixed with nonirritant adhesive plaster and bandage, sub-cage rearing.Administration is for 24 hours
Afterwards, left drug is removed with warm water, remove 0.5 after drug, 1,24,48,72h observe and record smear position whether there is or not erythema and
Oedema commonly uses standards of grading judge, score value and recovery feelings of the record each group in different time by skin irritation reaction
Condition.It is anti-that the external application promoting blood circulation and pain relieve composition of acetonideexample 1 is showed no other irritations to complete group of skin and skin injury group
It answers.
Skin anaphylactic test takes healthy albino guinea-pig 30, and half male and half female, weight 250-300g for 24 hours will be every before administration
Guinea pig back both sides unhairing (3cm × 3cm).Plucked cavy is divided into three groups by laboratory, test medicine group, blank control
Group (giving physiological saline) and positive controls (1%2,4 one nitrochlorobenzol), every group 10 (each 5 of male and female).Sensitization connects
It touches：The external application promoting blood circulation and pain relieve composition 1.0ml of embodiment 1, which is applied on the left of animal, goes to hair-fields and with one layer of glassine paper and two layers of gauze
Covering, then use nonirritant immobilization with adhesive tape, persistently 6h.It is primary in kind respectively to repeat sensitization within 7th day and the 14th day.Blank pair
Relative medicine is given respectively with method according to group and positive controls carries out sensitization contact.Excitation contact：In 14d after the last administration by phase
It answers drug 1.0ml to be applied on the right side of guinea pig back to go hair-fields, to remove drug i.e. observable after 6h, then see again in 24,48,72h
Examine cutaneous anaphylaxis situation.As a result test medicine group and blank control group do not occur erythema, oedema, asthma, astasia
Or the serious systemic anaphylaxis such as shock, no sensitization.There is erythema oedema of being significantly poisoned in positive controls, reflection
Average value is 4, sensitization rate 100%, is in exquisite sensitivity.The experimental results showed that external application promoting blood circulation and pain relieve composition to cavy without skin
Allergic reaction influences very little to body immune system.
Through skin sensibiligen, skin irritation test and skin anaphylactic test, the results showed that the external application of embodiment 1 is invigorated blood circulation
Relieve the pain composition to rabbit without apparent acute toxic reaction, it is nonirritant to rabbit intact skin group and damaged skin group, it is right
Cavy is without cutaneous anaphylaxis.Illustrate that this formulations toxic is very small, safety is preferable.The experimental result of embodiment 2-4 and embodiment 1
It is almost the same.
Embodiment 6：Mouse acetic acid twisting is tested
Experiment mice is randomly divided into：Negative control group, positive controls, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment,
With embodiment 4 groups every group 10.Before experiment for 24 hours, mouse back is given to lose hair or feathers with vulcanized sodium (7%), lose hair or feathers area 1cm × 1cm, standby
With.Negative control group is directly to give the group of acetic acid stimulation not to any drug.Voltarol positive controls are carried on the back in mouse
Portion is uniformly smeared appropriate (containing 400 μ ɡ of active ingredient/every animal), is tested after 30min.Embodiment 1-4 groups are carried on the back in mouse
0.29g embodiment 1-4 compositions (being 900 μ ɡ/every animal containing active ingredient) are uniformly smeared in portion respectively, are carried out after 30min
Experiment.After reaching the stipulated time, 0.6% acetic acid 0.2ml is injected in every group of mouse peritoneal, mouse in 20min is observed and writhing occurs
There is abdomen indent, trunk and hind leg and uphold in the number of reaction, i.e. mouse, and the behavior reactions such as hips up record writhing number,
And calculate the inhibiting rate that relieves the pain of drug.Every animal is only used primary in an experiment.
The writhing number of mouse is recorded, inhibiting rate is calculated.Inhibiting rate (%)=((negative control group is averaged writhing number one
Administration group is averaged writhing number)/negative control group is averaged writhing number) × 100%.Be t between group examine more each administration group with
The negative group of influence to the tested group of mouse threshold of pain, the effect of relieving the pain of comparative drug, as a result such as table 1.Acetic acid cause mouse writhing method be
A kind of weak antalgica of screening is a kind of sensitive, easy, reproducible method.The disadvantage is that timeliness cannot be carried out in same animal
Analysis, animal dosage is more, and lacks specificity, and not only antalgica is effective, some non-antalgica such as central depressants and benefit
Cacaine, atropine etc., it is also possible to positive findings occur, therefore other experimental evidence must be aided with, the effect of relieving the pain could be established.Cause
This has redesigned the experiment of mouse hot-plate induced pain method to verify the effect of relieving the pain of plant Chinese medicine drug composition.
1 experimental result of table
| Number of animals | Writhing number in 15 minutes | Inhibitory rate | |
| Blank group | 10 | 47.0±8.00 | |
| Positive group | 10 | 28.6±7.0 | 39.15 |
| Embodiment 1 | 10 | 29.6±8.8 | 37.02 |
| Embodiment 2 | 10 | 35.8±6.5 | 23.83 |
| Embodiment 3 | 10 | 30.5±6.0 | 35.11 |
| Embodiment 4 | 10 | 30.0±8.5 | 36.17 |
Embodiment 7：Mouse hot-plate induced pain is tested
Because the testis of male mice is more sensitive to hot plate, experiment mice is all made of female KM kind mouse, is randomly divided into：
Negative control group, positive controls, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment and embodiment 4 groups every group 10.Before experiment
For 24 hours, mouse back is given to lose hair or feathers with vulcanized sodium (7%), depilation area 1cm × 1cm is spare.Negative control group is not to any medicine
Object.Voltarol positive controls are uniformly smeared appropriate (containing 400 μ ɡ of active ingredient/every animal) in mouse back, after 30min
It is tested.4 groups of 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment and embodiment uniformly smear 0.30 μ respectively in mouse back
The composition of the composition of L embodiments 1, the composition that 2 groups of embodiment, 4 groups of the composition and embodiment that 3 group of embodiment (contains
It is 900 μ ɡ/every animal to imitate ingredient), it is tested after 30min.Every group of l0 is only.Hot plate stimulates temperature to keep (55+0.5
DEG C), normal mouse is placed on thermometal disk, is referred to as the threshold of pain from time of the mouse metapedes contact hot plate until licking metapedes
Mark, is selected>5s and<The sensitive mouse 60 stablized of 30s reactions is served only for testing.60 mouse are randomly divided into 6 groups, before experiment
For 24 hours, mouse back is given to lose hair or feathers with vulcanized sodium (7%), depilation area 1cm × 1cm is spare.Before administration being measured before experiment 1h again
The threshold of pain.Negative control group is not to any drug and Blank gel matrix.Voltarol positive controls are uniform in mouse back
It smears appropriate (containing active ingredient 400pg).4 groups of 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment and embodiment (contain active ingredient
It is 900I_tg).Negative control group measures the threshold of pain respectively at 15,30,45,60,90min.Remaining each group mouse is respectively at coating
Afterwards 15,30,45,60,90min measures the threshold of pain again.To prevent foot from scalding, it is 60s, mouse after medication to test deadline every time
Incubation period reaches 60s person and stops experiment and in terms of 60s.Every animal in an experiment only once.
Mouse pawl toe is very sensitive to thermostimulation, places it on 55 ± 0.5 DEG C of hot plates after a certain period of time, Different Individual pair
Hot plate stimulate the reaction has different performances, majority to lick foot, therefore is pain reaction indicator frequently with foot is licked.Mouse is placed on hot plate
Timing definition until it above-mentioned reaction occurs is the threshold of pain.Antalgica can extend mouse and the time of pain reaction occurs, reflect it
Analgesic effect, therefore this model can be used for evaluating the analgesic effect of drug.T examines more each administration group and negative group between doing group
Influence to the tested group of mouse threshold of pain, the effect of relieving the pain of comparative drug.Experimental result is shown in Table 2.From the data to experimental result into
Row is analysis shows that 1 group of embodiment, 2 groups of embodiment, the influence of 4 groups of 3 groups of embodiment and embodiment to mouse hot-plate induced pain pain threshold
Than more significant.The effect of positive drug Voltarol is not notable.
2 external application promoting blood circulation and pain relieve composition experimental result of table
Embodiments of the present invention are explained in detail above, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (1)
1. a kind of external application promoting blood circulation and pain relieve composition, it is characterised in that：It is made of following component and percent by volume：Safflower oil 40-
70%, Japan cypress oil 30-55%, tea oil 5-10%, pinke needle oil 20-40%, oil of juniper wood 20-40% and B component essential oil 5-15%；
The B component essential oil is the supercritical extract of following weight parts component：
5 parts of lopseed, 4 parts of the root of Dahurain angelica, 12 parts of fennel seeds, 7 parts of cloves, 5 parts of Radix Angelicae Sinensis, 2 parts of west safflower, 9 parts of rhizoma zingiberis, 13 parts of rhizoma cyperi,
5 parts of cassia twig, 11 parts of folium artemisiae argyi, 13 parts of RADIX CURCUMAE, 2 parts of frankincense, 2 parts of myrrh, 3 parts of kamuning, 4 parts of Radix Salviae Miltiorrhizae, 5 parts of the root of Chinese clematis, radix bupleuri
10 parts, 5 parts of Radix Codonopsis, 5 parts of fingered citron, 6 parts of Radix Ophiopogonis, 5 parts of Radix Astragali, 15 parts of lycopodium calvatum, Psoralen grass 15 parts, 10 parts of Rhizoma Atractylodis Macrocephalae, smilax 5
Part, 4 parts of pawpaw, 3 parts of Curcuma wenyujin, 5 parts of Semen Cuscutae, 10 parts of pueraria lobata, 7 parts of Caulis Spatholobi, 8 parts of cacumen biotae, 5 parts of Rhizoma Et Radix Notopterygii, frutus cnidii 15
Part, 12 parts of the fruit of summer cypress, 10 parts of coix seed, 5 parts of dried rehamnnia root, 10 parts of trigone, 6 parts windproof, 8 parts of 5 parts of drooping stringbush flower root and bark and Chinese prickly ash；
The supercritical extraction method of the B component essential oil is：Raw material crush, and cross 40-60 mesh sieve, and it is mixed to match merging in parts by weight
It is even；It is packed into extraction kettle, the parameters of extraction kettle are debugged in sealing, and separating still, heating apparatus and refrigerating plant normal work are beaten
It opens compression pump and is pressurised into 21-22Mpa, pumping liquid C02Plants essential oil is extracted, extract is parsed from separating still, obtains B component essence
Oil.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109528899A (en) * | 2018-12-29 | 2019-03-29 | 深圳市淳睿贸易有限公司 | Radix bupleuri massage oil, preparation method and its application |
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