CN108392619A - A kind of plant extracts of analgesic and preparation method thereof - Google Patents
A kind of plant extracts of analgesic and preparation method thereof Download PDFInfo
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- CN108392619A CN108392619A CN201810509919.1A CN201810509919A CN108392619A CN 108392619 A CN108392619 A CN 108392619A CN 201810509919 A CN201810509919 A CN 201810509919A CN 108392619 A CN108392619 A CN 108392619A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of plant extracts of analgesic and preparation method thereof, are extracted by plant composition, and the plant composition includes by weight part：Holy basil or 5 10 parts of 58 parts of 5 10 parts of 8 15 parts of fennel, 58 parts of galangal, 6 10 parts of elscholtiza, hairyvein agrimony or Caulis Spatholobi, 58 parts of fingered citron, 5 10 parts of Radix Salviae Miltiorrhizae, capsicum or pericarpium zanthoxyli, 6 13 parts of rhizoma cyperi, 5 11 parts of folium artemisiae argyi, 59 parts of frankincense, 59 parts of myrrh, resina liquidamberis or turpentine, 4 10 parts of caulis trachelospermi, 5 15 parts of radix bupleuri, drooping stringbush flower root and bark or 38 parts of 3 10 parts windproof, 58 parts of rhizoma zingiberis, 58 parts of frutus cnidii and turmeric.Energy promoting blood circulation to remove blood stasis, relaxing relieves the pain through dredging collateral, detumescence, and pure plant is nontoxic；For neck shoulder, waist-leg pain, extremities joint and rheumatism, especially blood stasis inside caused by various pain problems have special efficacy, preparation process is simple, extract yield improves 5 50 times compared with prior art, and extract is not volatile, and Transdermal absorption is more preferable, input cost and the cost of production substantially reduce, and raw material sources are convenient.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of plant extracts of analgesic and preparation method thereof.
Background technology
Pain is derived from the damage of bodily tissue first.This generates the substance of some pain, the receptor of stimulation pain.These
The stimulation of chemical substance is transformed into pulse in nerve cell, through A δ and C nerve conductions to spinal cord, brain stem, Thalamus and brain.Pain
Pain conduction has no personal difference until Thalamus.Determine that individual is brain to the reaction of pain.During antalgesic mainly acts on
Pivot or peripheral neverous system, selective depression and the various pain of alleviation, mitigate pain and cause frightened nervous and uneasiness mood pain
Drug.The anodyne of Western medicine includes narcotic analgeiscs using morphine as representative and using aspirin as the antipyretic-antalgic of representative
Anti-inflammatory agent has played great function in terms of releasing patient suffering.But some antalgesic Reusabilities, are also easy to produce additive.It is all
The drug of easy habituation, is generally called " narcotic analgeiscs ", is classified as in medicine management " narcotics ", and country promulgates《Narcotics
Management rules》, to production and supply and using all strictly being managed and being limited, to ensure people's health.The analgesic of existing Chinese medicine
Drug, no matter Chinese medicine or Western medicine, be mostly to benumb based on nerve, side effect is big, palliative, is easy habituation, and does not have
There is the corresponding formula for different body parts；Existing extraction process, extraction time is slow, though also there is the heating extraction time fast
Way, but a large amount of invalid components of extraction are easy, impurity is more.Complex process, the ratio that extract extracts is low, and extract is pure
Degree is not high.
Invention content
The object of the present invention is to provide a kind of plant extracts of analgesic and preparation method thereof, energy promoting blood circulation to remove blood stasis relaxes
It relieves the pain through dredging collateral, detumescence, pure plant is nontoxic；For neck shoulder, waist-leg pain, extremities joint, rheumatism and gout, especially
Be blood stasis inside caused by various pain problems have special efficacy.
The object of the present invention is to provide a kind of plant extracts of analgesic and preparation method thereof, and preparation process is simple,
Extract yield improves 5-50 times compared with prior art, and extract is not volatile, and Transdermal absorption is more preferable, the purity of extraction
The cost of height, input cost and production substantially reduces, and raw material sources are convenient.
In order to achieve the above object, the major technique solution of the present invention is to provide a kind of plant extracts of analgesic, by planting
Compositions extract, and the plant composition includes by weight part：Holy basil or 8-15 parts of fennel, galangal 5-8
Part, 6-10 parts of elscholtiza, hairyvein agrimony or 5-10 parts of Caulis Spatholobi, 5-8 parts of fingered citron, 5-10 parts of Radix Salviae Miltiorrhizae, capsicum or 5-8 parts of pericarpium zanthoxyli, rhizoma cyperi
5-10 parts of 6-13 parts, 5-11 parts of folium artemisiae argyi, 5-9 parts of frankincense, 5-9 parts of myrrh, resina liquidamberis or turpentine, 4-10 parts of caulis trachelospermi, radix bupleuri 5-
15 parts, drooping stringbush flower root and bark or 3-8 parts of 3-10 parts windproof, 5-8 parts of rhizoma zingiberis, 5-8 parts of frutus cnidii and turmeric.
At some in the embodiment of shoulder neck position analgesic, the plant composition to further include 5-10 parts of cassia twig, Radix Angelicae Sinensis
5-10 parts of 3-10 parts, 5-10 parts of the root of Chinese clematis, 7-10 parts of Radix Angelicae Pubescentis and spina gleditsiae.
At some in the embodiment of waist-leg position analgesic, the plant composition to further include 5-10 parts of radix achyranthis bidentatae, Lay
5-8 parts of 5-7 parts of Fu, 5-10 parts of Radix Notoginseng, 6-13 parts of RADIX CURCUMAE, 5-8 parts of Fructus Corni and teasel root.
In some are for the embodiment of extremities joint and rheumatic pain killing, the plant composition further includes：Stauntonvine 6-
6-10 parts of 12 parts, 7-10 parts of kaempferia galamga, 5-10 parts of ramulus mori, 5-8 parts of Rhizoma Chuanxiong, 7-10 parts of caulis trachelospermi, 5-12 parts of paenoiae alba and schefflera arboricola.
At some in the embodiment of comprehensive analgesic, the plant composition to further include 5-10 parts of cassia twig, Radix Angelicae Sinensis 3-10
Part, 5-10 parts of the root of Chinese clematis, 7-10 parts of Radix Angelicae Pubescentis, 5-10 parts of spina gleditsiae, 5-10 parts of radix achyranthis bidentatae, 5-7 parts of radish seed, 5-10 parts of Radix Notoginseng,
6-13 parts of RADIX CURCUMAE, 5-8 parts of Fructus Corni, 5-8 parts of teasel root, 6-12 parts of stauntonvine, 7-10 parts of kaempferia galamga, 5-10 parts of ramulus mori, Rhizoma Chuanxiong 5-8
6-10 parts of part, 7-10 parts of caulis trachelospermi, 5-12 parts of paenoiae alba and schefflera arboricola.
It is for wind-expelling pain-stopping medicine in above-mentioned formula：Holy basil, cassia twig, drooping stringbush flower root and bark, ramulus mori.
It is for eliminating cold to stop pain medicine in above-mentioned formula：Kaempferia galamga, rhizoma zingiberis, galangal, folium artemisiae argyi, capsicum, spina gleditsiae.
It is for damp-clearing pain-relieving medicine in above-mentioned formula：Elscholtiza, frutus cnidii, Radix Angelicae Pubescentis.
It is for medicines for regulating qi and alleviating pain in above-mentioned formula：Radix bupleuri, rhizoma cyperi, radish seed.
It is for blood-activating analgesic in above-mentioned formula：Hairyvein agrimony, Radix Angelicae Sinensis, Radix Notoginseng, teasel root, schefflera arboricola, RADIX CURCUMAE, turmeric,
Frankincense, myrrh, stauntonvine, Rhizoma Chuanxiong, resina liquidamberis, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae.
It is for medicine of removing obstruction in channels to relieve pain in above-mentioned formula：The root of Chinese clematis, caulis trachelospermi.
It is for help anodyne in above-mentioned formula：Radix Astragali, Radix Angelicae Sinensis, Fructus Corni, hairyvein agrimony.
It is for relieving spasm to stop pain medicine in above-mentioned formula：Paenoiae alba.
Wherein, the cassia twig, drooping stringbush flower root and bark, ramulus mori, spina gleditsiae, frutus cnidii, Radix Angelicae Pubescentis, radish seed, Radix Angelicae Sinensis, teasel root, RADIX CURCUMAE,
Turmeric, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae, the root of Chinese clematis, caulis trachelospermi, Radix Astragali, Fructus Corni and paenoiae alba are to nourish class or rhizome constituents,
Remaining ingredient is flowers and plants.
The invention also discloses the plant extracts preparation methods of above-mentioned analgesic, include the following steps：
(5) the nourishing class component in formula is mixed according to the ratio and is smashed, be then placed in steamer steaming；
(6) remaining component in formula is mixed according to the ratio and is smashed, the steamer being put into after nourishing class component in step (1)
It steams, after cooking, cooling is spare；
(7) red yeast rice is added in the medicinal material cooked in step (2) to ferment as catalyst, dry after fermentation spare；
(8) dregs of a decoction are filtered off after being soaked for a period of time the medicinal material dried in step (3) with alcohol and obtain filtrate, and decompression is steamed
Do the plant extracts that paste is relieved pain.
Component is smashed to 20-60 mesh sizes in the step (1).
Cassia twig described in the step (2), ramulus mori, spina gleditsiae, frutus cnidii, Radix Angelicae Pubescentis, radish seed, Radix Angelicae Sinensis, continues at drooping stringbush flower root and bark
Disconnected, RADIX CURCUMAE, turmeric, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae, the root of Chinese clematis, caulis trachelospermi, Radix Astragali, Fructus Corni, Radix Astragali, Fructus Corni and paenoiae alba
For nourishing class or rhizome constituents, remaining is is steamed under after flowers and plants class component.
The amount that red yeast rice adds in the step (3) is 1/4 to the 1/3 of the weight of the medicinal material cooked, and fermentation temperature exists
36-39 degree, the red yeast rice are added together with Radix Notoginseng powder.
Alcohol in the step (3) includes the concentration of the alcohol and fermentation of the concentration do not fermented more than or equal to 95%
Alcohol more than or equal to 75%, described to impregnate to cover immersion, it is 4-8 hours to impregnate, and uses absolute ethyl alcohol in some embodiments.
It is basic using heating in existing extraction, and because there is moisture, easy to be mouldy, not easy to maintain, step (4) decompression is steamed
Dry condition is negative pressure 0.08pa, temperature 55-60 degree, and 55-60 degree is to digest most ideal temperature.Extracting method described in the present embodiment
Yield is high, and same 100 kilograms of plant compositions, existing supercritical extract etc. can probably extract 3.7kg extracts or so, and
The method of the present embodiment can extract 20 kilograms or so of extract, probably improve 5-50 times.
The plant extracts 5%-10%, oil of juniper wood 50-65% and SIMMONDSIA CHINENSIS SEED OIL 25-40% are prepared by weight percentage
Form the dosage form of essential oil.
Cataplasm can be added in the plant extracts and can be used as gel preparations, the cataplasm can be carbomer, third
One kind or combinations thereof in olefin(e) acid or first acrylic acid three, the preparation method of cataplasm content and specific gel in gel preparations
For the prior art.
Acrylate pressure sensitive adhesive is added in the plant extracts and does plaster dosage form, is then coated using non-woven fabrics as lining cloth described
Plaster, then silicone oil paper is covered, the preparation method of the content of the acrylate pressure sensitive adhesive in plaster dosage form and specific plaster is existing skill
Art.
Specific implementation mode
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
The every other embodiment that technical staff is obtained, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of plant extracts of the described analgesic for the analgesic of shoulder neck position of the present embodiment, is carried by plant composition
It takes, the plant composition includes by weight part：Holy basil or 8 parts of fennel, 5 parts of galangal, 6 parts of elscholtiza, red crowned crane
Grass or 5 parts of 5 parts of Caulis Spatholobi, 5 parts of fingered citron, 5 parts of Radix Salviae Miltiorrhizae, capsicum or pericarpium zanthoxyli, 6 parts of rhizoma cyperi, 5 parts of folium artemisiae argyi, 5 parts of frankincense, 5 parts of myrrh,
Resina liquidamberis or 5 parts of turpentine, 4 parts of caulis trachelospermi, 5 parts of radix bupleuri, drooping stringbush flower root and bark or 3 parts windproof, 5 parts of rhizoma zingiberis, 5 parts of frutus cnidii, 3 parts of turmeric,
5 parts of 5 parts of cassia twig, 3 parts of Radix Angelicae Sinensis, 5 parts of the root of Chinese clematis, 7 parts of Radix Angelicae Pubescentis and spina gleditsiae.
Embodiment 2
The described plant extracts for the analgesic of waist-leg position of the present embodiment, is extracted, institute by plant composition
Stating plant composition includes by weight part：Holy basil or 15 parts of fennel, 8 parts of galangal, 10 parts of elscholtiza, hairyvein agrimony or chicken blood
8 parts of 10 parts of rattan, 8 parts of fingered citron, 10 parts of Radix Salviae Miltiorrhizae, capsicum or pericarpium zanthoxyli, 13 parts of rhizoma cyperi, 11 parts of folium artemisiae argyi, 9 parts of frankincense, 9 parts of myrrh, sweetgum
Fat or 10 parts of turpentine, 10 parts of caulis trachelospermi, 15 parts of radix bupleuri, drooping stringbush flower root and bark or 10 parts windproof, 8 parts of rhizoma zingiberis, 8 parts of frutus cnidii, 8 parts of turmeric,
8 parts of 10 parts of radix achyranthis bidentatae, 7 parts of radish seed, 10 parts of Radix Notoginseng, 13 parts of RADIX CURCUMAE, 8 parts of Fructus Corni and teasel root.
Embodiment 3
The described plant extracts for being used for extremities joint and rheumatic pain killing of the present embodiment, by plant composition extraction
At the plant composition includes by weight part：8 parts of holy basil or fennel, 5 parts of galangal, 6 parts of elscholtiza, hairyvein agrimony or
5 parts of 5 parts of Caulis Spatholobi, 5 parts of fingered citron, 5 parts of Radix Salviae Miltiorrhizae, capsicum or pericarpium zanthoxyli, 6 parts of rhizoma cyperi, 5 parts of folium artemisiae argyi, 5 parts of frankincense, 5 parts of myrrh, sweetgum
Fat or 5 parts of turpentine, 4 parts of caulis trachelospermi, 5 parts of radix bupleuri, drooping stringbush flower root and bark or 3 parts windproof, 5 parts of rhizoma zingiberis, 5 parts of frutus cnidii, 3 parts of turmeric, wild wood
6 parts of 6 parts of melon, 7 parts of kaempferia galamga, 5 parts of ramulus mori, 5 parts of Rhizoma Chuanxiong, 7 parts of caulis trachelospermi, 5 parts of paenoiae alba and schefflera arboricola.
Embodiment 4
The described plant extracts for comprehensive analgesic of the present embodiment, is extracted, the plant by plant composition
Compositions include by weight part：Holy basil or 15 parts of fennel, 8 parts of galangal, 10 parts of elscholtiza, hairyvein agrimony or Caulis Spatholobi 10
8 parts of part, 8 parts of fingered citron, 10 parts of Radix Salviae Miltiorrhizae, capsicum or pericarpium zanthoxyli, 13 parts of rhizoma cyperi, 11 parts of folium artemisiae argyi, 9 parts of frankincense, 9 parts of myrrh, resina liquidamberis or
10 parts of turpentine, 10 parts of caulis trachelospermi, 15 parts of radix bupleuri, drooping stringbush flower root and bark or 10 parts windproof, 8 parts of rhizoma zingiberis, 8 parts of frutus cnidii, 3 parts of turmeric, cassia twig 5
Part, 3 parts of Radix Angelicae Sinensis, 5 parts of the root of Chinese clematis, 7 parts of Radix Angelicae Pubescentis, 5 parts of spina gleditsiae, 10 parts of radix achyranthis bidentatae, 7 parts of radish seed, 10 parts of Radix Notoginseng, RADIX CURCUMAE 13
Part, 8 parts of Fructus Corni, 8 parts of teasel root, 6 parts of stauntonvine, 7 parts of kaempferia galamga, 5 parts of ramulus mori, 5 parts of Rhizoma Chuanxiong, 7 parts of caulis trachelospermi, 5 parts of paenoiae alba and
6 parts of schefflera arboricola.
It is for wind-expelling pain-stopping medicine in above-mentioned formula：Holy basil, cassia twig, drooping stringbush flower root and bark, ramulus mori.
It is for eliminating cold to stop pain medicine in above-mentioned formula：Kaempferia galamga, rhizoma zingiberis, galangal, folium artemisiae argyi, capsicum, spina gleditsiae.
It is for damp-clearing pain-relieving medicine in above-mentioned formula：Elscholtiza, frutus cnidii, Radix Angelicae Pubescentis.
It is for medicines for regulating qi and alleviating pain in above-mentioned formula：Radix bupleuri, rhizoma cyperi, radish seed.
It is for blood-activating analgesic in above-mentioned formula：Hairyvein agrimony, Radix Angelicae Sinensis, Radix Notoginseng, teasel root, schefflera arboricola, RADIX CURCUMAE, turmeric,
Frankincense, myrrh, stauntonvine, Rhizoma Chuanxiong, resina liquidamberis, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae.
It is for medicine of removing obstruction in channels to relieve pain in above-mentioned formula：The root of Chinese clematis, caulis trachelospermi.
It is for help anodyne in above-mentioned formula：Radix Astragali, Radix Angelicae Sinensis, Fructus Corni, hairyvein agrimony.
It is for relieving spasm to stop pain medicine in above-mentioned formula：Paenoiae alba.
Wherein, the cassia twig, drooping stringbush flower root and bark, ramulus mori, spina gleditsiae, frutus cnidii, Radix Angelicae Pubescentis, radish seed, Radix Angelicae Sinensis, teasel root, RADIX CURCUMAE,
Turmeric, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae, the root of Chinese clematis, caulis trachelospermi, Radix Astragali, Fructus Corni and paenoiae alba are to nourish class or rhizome constituents,
Remaining ingredient is flowers and plants class.
Embodiment 5
A kind of plant extracts of analgesic described in the present embodiment, is extracted by plant composition, the plant society
Object includes by weight part：Holy basil or 8 parts of fennel, 5 parts of galangal, 6 parts of elscholtiza, hairyvein agrimony or 5 parts of Caulis Spatholobi, fingered citron 5
Part, 5 parts of Radix Salviae Miltiorrhizae, capsicum or 5 parts of pericarpium zanthoxyli, 6 parts of rhizoma cyperi, 5 parts of folium artemisiae argyi, 5 parts of frankincense, 5 parts of myrrh, resina liquidamberis or 5 parts of turpentine, trachelospermum jasminoide
4 parts of rattan, 5 parts of radix bupleuri, drooping stringbush flower root and bark or 3 parts windproof, 5 parts of rhizoma zingiberis, 5 parts of frutus cnidii, 3 parts of turmeric.
Embodiment 6
The plant extracts preparation method relieved pain described in the present embodiment, includes the following steps：
(1) the nourishing class component in formula is mixed according to the ratio and is smashed to 20-60 mesh sizes, be then placed in steamer steaming；
(2) remaining component in formula is mixed according to the ratio and is smashed, the steamer being put into after nourishing class component in step (1)
It steams, after cooking, cooling is spare；
(3) 1/4 to 1/3 red yeast rice of the weight of the medicinal material cooked described in addition in the medicinal material cooked in step (2) is made
It ferments for catalyst, fermentation temperature is added in 36-39 degree, the red yeast rice with Radix Notoginseng powder, dries after fermentation spare together；
(4) by the medicinal material dried in step (3) with the concentration that do not ferment more than or equal to 95% alcohol or fermentation it is dense
Alcohol of the degree more than or equal to 75%, covered immersion, 4-8 hours.The dregs of a decoction are filtered off after being soaked for a period of time and obtain filtrate, in negative pressure
0.08pa, temperature 55-60 degree evaporated under reduced pressure to paste are the plant extracts relieved pain.
Cassia twig described in the step (2), ramulus mori, spina gleditsiae, frutus cnidii, Radix Angelicae Pubescentis, radish seed, Radix Angelicae Sinensis, continues at drooping stringbush flower root and bark
Disconnected, RADIX CURCUMAE, turmeric, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae, the root of Chinese clematis, caulis trachelospermi, Radix Astragali, Fructus Corni and paenoiae alba are nourishing class or root
Stem constituents, remaining is is steamed under after flowers and plants class component.
In some embodiments, prepare by weight percentage the plant extracts 5%-10%, oil of juniper wood 50-65% and
The dosage form of SIMMONDSIA CHINENSIS SEED OIL 25-40% composition essential oils.
In some embodiments, cataplasm can be added in the plant extracts and can be used as gel preparations, the cataplasm
Can be one kind or combinations thereof in carbomer, acrylic acid or first acrylic acid three, the cataplasm content in gel preparations and tool
The preparation method of body gel is the prior art.
In some embodiments, acrylate pressure sensitive adhesive is added in the plant extracts and does plaster dosage form, then with nonwoven
Cloth is that lining cloth coats the plaster, then covers silicone oil paper, the content of the acrylate pressure sensitive adhesive in plaster dosage form and specific plaster
Preparation method is the prior art.
The safety to skin is carried out using the extract of embodiment 4 to investigate：Including animal skin acute toxicity test, skin
Skin irritation test and skin anaphylactic test.
Experiment material：Experimental animal new zealand rabbit, regular grade, weight (2.0 ± 0.2) kg, male and female dual-purpose.Cavy, weight
250~300g male and female dual-purposes, are provided by Experimental Animal Center.
Experimental method and result：
Skin sensibiligen tests the new zealand rabbit 20 for taking weight (2.0 ± 0.2) kg, half male and half female, before administration
For 24 hours, by back backbone both sides unhairing, every is removed gross area about 150cm2 (about the 10% of body surface area).It is divided into 5 groups, every group 4
Only, control group every applies physiological saline lml；Each two groups of high low dose group (being respectively intact skin group and damaged skin group).Its
Skin of unhairing is sterilized and is scratched with needle by middle damaged skin.It is degree with oozing of blood.Carrying for embodiment 4 is coated on experimental group skin of unhairing
Take object, the extract 2.0ml of every painting embodiment 4 of low dose group, the extract 4.0ml of every painting embodiment 4 of high dose group,
It is even to be applied to hair removal section, it is used in combination nonirritant gauze, immobilization with adhesive tape, sub-cage rearing to be washed left drug with warm water after administration for 24 hours
Remove, remove 1 after drug, 24,48,72h to the 7th days, the feelings such as observation rabbit weight, skin, hair, eye, mucous membrane and breathing, activity
Condition, is showed no exception, and no death does not have notable difference compared with the control group.I.e. the extract of embodiment 4 is to new zealand rabbit skin
Acute toxicity very little prompts actual use safety.
Skin irritation test takes weight (2.0 ± 0.2) kg new zealand rabbits 20, half male and half female before administration for 24 hours will
Back backbone both sides unhairing, every is removed gross area about 3cm × 3cm.Using androgynous left and right sides Self-control method, it is divided into two groups, often
Group 4, completely group and skin injury group, rabbit right side apply physiological saline 1ml to skin, and left side applies the extract of embodiment 4
2.0ml.Skin of unhairing is sterilized and is scratched with needle by skin injury group, is degree with oozing of blood.After coating, with two layers of gauze 2.5cm ×
2.5cm and one layer of glassine paper covering, then fixed with nonirritant adhesive plaster and bandage, sub-cage rearing.After administration for 24 hours, with temperature
Water removes left drug, remove 0.5 after drug, 1,24,48,72h observe and record and smear that whether there is or not erythema and oedema at position, press
The generally common standards of grading of skin irritation reaction are judged, score value and recovery situation of the record each group in different time.As a result
The extract of embodiment 4 is showed no other irritative responses to complete group of skin and skin injury group.
Skin anaphylactic test takes healthy albino guinea-pig 30, and half male and half female, weight 250-300g for 24 hours will be every before administration
Guinea pig back both sides unhairing (3cm × 3cm).Plucked cavy is divided into three groups by laboratory, test medicine group, blank control
Group (giving physiological saline) and positive controls (1%2,4 one nitrochlorobenzol), every group 10 (each 5 of male and female).Sensitization connects
It touches：The extract 1.0ml of embodiment 4, which is applied on the left of animal, to be gone to hair-fields and is covered with one layer of glassine paper and two layers of gauze, then uses nothing
Irritation immobilization with adhesive tape continues 6h.It is primary in kind respectively to repeat sensitization within 7th day and the 14th day.Blank control group and the positive
Control group gives relative medicine with method and carries out sensitization contact respectively.Excitation contact：In 14d after the last administration by relative medicine
1.0ml is applied on the right side of guinea pig back and goes hair-fields, to remove drug i.e. observable after 6h, then observes skin again in 24,48,72h
Allergic reaction situation.As a result test medicine group and blank control group do not occur erythema, oedema, asthma, astasia or shock
Etc. serious systemic anaphylaxis, no sensitization.There is erythema oedema of being significantly poisoned in positive controls, and reflect average value
It is 4, sensitization rate 100% is in exquisite sensitivity.The experimental results showed that external application promoting blood circulation and pain relieve composition is anti-without skin allergy to cavy
It answers, very little is influenced on body immune system.
Through skin sensibiligen, skin irritation test and skin anaphylactic test, the results showed that the extract pair of embodiment 4
Rabbit is nonirritant to rabbit intact skin group and damaged skin group without apparent acute toxic reaction, to cavy without skin mistake
Quick reaction.Illustrate that this formulations toxic is very small, safety is preferable.The experimental result and embodiment of the extract of embodiment 1-3,5 and 6
4 is almost the same.
Embodiment 7：Mouse acetic acid twisting is tested
Experiment mice is randomly divided into：Negative control group, positive controls, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment,
5 groups of 4 groups of embodiment and embodiment, every group 10.Before experiment for 24 hours, it is lost hair or feathers to mouse back with vulcanized sodium (7%), lose hair or feathers area
1cm × 1cm, it is spare.Negative control group is directly to give the group of acetic acid stimulation not to any drug.Voltarol positive control
Group is uniformly smeared appropriate (containing 400 μ ɡ of active ingredient/every animal) in mouse back, is tested after 30min.Embodiment 1-5
Group uniformly smears 0.29g embodiment 1-5 extracts (being 900 μ ɡ/every animal containing active ingredient) respectively in mouse back,
It is tested after 30min.After reaching the stipulated time, 0.6% acetic acid 0.2ml is injected in every group of mouse peritoneal, is observed small in 20min
There is the number of writhing response in mouse, i.e. abdomen indent, trunk and hind leg extension, the behavior reactions such as hips up, note occurs in mouse
Writhing number is recorded, and calculates the inhibiting rate that relieves the pain of drug.Every animal is only used primary in an experiment.
The writhing number of mouse is recorded, inhibiting rate is calculated.Inhibiting rate (%)=((negative control group is averaged writhing number one
Administration group is averaged writhing number)/negative control group is averaged writhing number) × 100%.Be t between group examine more each administration group with
The negative group of influence to the tested group of mouse threshold of pain, the effect of relieving the pain of comparative drug, as a result such as table 1.Acetic acid cause mouse writhing method be
A kind of weak antalgica of screening is a kind of sensitive, easy, reproducible method.The disadvantage is that timeliness cannot be carried out in same animal
Analysis, animal dosage is more, and lacks specificity, and not only antalgica is effective, some non-antalgica such as central depressants and benefit
Cacaine, atropine etc., it is also possible to positive findings occur, therefore other experimental evidence must be aided with, the effect of relieving the pain could be established.Cause
This has redesigned the experiment of mouse hot-plate induced pain method to verify the effect of relieving the pain of plant Chinese medicine drug composition.
1 experimental result of table
Embodiment 8：Mouse hot-plate induced pain is tested
Because the testis of male mice is more sensitive to hot plate, experiment mice is all made of female KM kind mouse, hot plate stimulation
Temperature keeps (55+0.5 DEG C), and normal mouse is placed on thermometal disk, and hot plate is contacted until licking metapedes from mouse metapedes
Time as pain indicator, is selected>5s and<The sensitive mouse 70 stablized of 30s reactions is served only for testing, and is randomly divided into 7 groups：It is negative
5 groups, every group 10 of control group, positive controls, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment and embodiment
Only.Before experiment for 24 hours, mouse back is given to lose hair or feathers with vulcanized sodium (7%), lose hair or feathers area 1cm × 1cm, spare.Negative control group is not
To any drug.Voltarol positive controls uniformly smear appropriate (containing 400 μ ɡ of active ingredient/every animal) in mouse back,
Embodiment 1-5 groups, it (is 900 μ containing active ingredient uniformly to smear the extract of 0.30 μ L embodiments 1-5 respectively in mouse back
ɡ/every animal), the threshold of pain before administration is measured again before testing 1h.Negative control group is surveyed respectively at 15,30,45,60,90min
Analgesic therapy threshold.Remaining each group mouse 15 after coating, 30,45,60,90min measure the threshold of pain again.To prevent foot from scalding, often
Secondary experiment deadline be 60s, after medication mouse incubation period reach 60s person stop experiment and in terms of 60s.Every animal is being tested
In only once.
Mouse pawl toe is very sensitive to thermostimulation, places it on 55 ± 0.5 DEG C of hot plates after a certain period of time, Different Individual pair
Hot plate stimulate the reaction has different performances, majority to lick foot, therefore is pain reaction indicator frequently with foot is licked.Mouse is placed on hot plate
Timing definition until it above-mentioned reaction occurs is the threshold of pain.Antalgica can extend mouse and the time of pain reaction occurs, reflect it
Analgesic effect, therefore this model can be used for evaluating the analgesic effect of drug.T examines more each administration group and negative group between doing group
Influence to the tested group of mouse threshold of pain, the effect of relieving the pain of comparative drug.Experimental result is shown in Table 2.From the data to experimental result into
Row is analysis shows that 1 group of embodiment, and 2 groups of embodiment, 5 groups of 3 groups of embodiment, 4 groups of embodiment and embodiment are to mouse hot-plate induced pain pain
The influence of threshold value is than more significant.The effect of positive drug Voltarol is not notable.
2 experimental result of table
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is every that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (10)
1. a kind of plant extracts of analgesic, is extracted by plant composition, which is characterized in that the plant composition is with weight
Measuring component meter includes：Holy basil or 5-10 parts of 8-15 parts of fennel, 5-8 parts of galangal, 6-10 parts of elscholtiza, hairyvein agrimony or Caulis Spatholobi,
5-8 parts of 5-8 parts of fingered citron, 5-10 parts of Radix Salviae Miltiorrhizae, capsicum or pericarpium zanthoxyli, 6-13 parts of rhizoma cyperi, 5-11 parts of folium artemisiae argyi, 5-9 parts of frankincense, myrrh 5-9
Part, resina liquidamberis or 5-10 parts of turpentine, 4-10 parts of caulis trachelospermi, 5-15 parts of radix bupleuri, drooping stringbush flower root and bark or 3-10 parts windproof, 5-8 parts of rhizoma zingiberis, snake
3-8 parts of 5-8 parts of machine tool and turmeric.
2. the plant extracts of analgesic according to claim 1, it is characterised in that the plant composition further includes cassia twig
5-10 parts of 5-10 parts, 3-10 parts of Radix Angelicae Sinensis, 5-10 parts of the root of Chinese clematis, 7-10 parts of Radix Angelicae Pubescentis and spina gleditsiae.
3. the plant extracts of analgesic according to claim 1, it is characterised in that the plant composition further includes bosom ox
5-8 parts of 5-10 parts of knee, 5-7 parts of radish seed, 5-10 parts of Radix Notoginseng, 6-13 parts of RADIX CURCUMAE, 5-8 parts of Fructus Corni and teasel root.
4. the plant extracts of analgesic according to claim 1, it is characterised in that the plant composition further includes：Wild wood
6-12 parts of melon, 7-10 parts of kaempferia galamga, 5-10 parts of ramulus mori, 5-8 parts of Rhizoma Chuanxiong, 7-10 parts of caulis trachelospermi, 5-12 parts of paenoiae alba and schefflera arboricola 6-
10 parts.
5. the plant extracts of analgesic according to claim 1, it is characterised in that the plant composition further includes cassia twig
5-10 parts, 3-10 parts of Radix Angelicae Sinensis, 5-10 parts of the root of Chinese clematis, 7-10 parts of Radix Angelicae Pubescentis, 5-10 parts of spina gleditsiae, 5-10 parts of radix achyranthis bidentatae, radish seed 5-7
Part, 5-10 parts of Radix Notoginseng, 6-13 parts of RADIX CURCUMAE, 5-8 parts of Fructus Corni, 5-8 parts of teasel root, 6-12 parts of stauntonvine, 7-10 parts of kaempferia galamga, ramulus mori
6-10 parts of 5-10 parts, 5-8 parts of Rhizoma Chuanxiong, 7-10 parts of caulis trachelospermi, 5-12 parts of paenoiae alba and schefflera arboricola.
6. the plant extracts preparation method of analgesic according to any one of claims 1 to 5, which is characterized in that including walking as follows
Suddenly：
(1) by formula nourishing class and tubers component mix smash according to the ratio, be then placed in steamer steaming；
(2) remaining component in formula is mixed according to the ratio and is smashed, the steaming being put into after nourishing class and tubers component in step (1)
Pot steams, and after cooking, cooling is spare；
(3) red yeast rice is added in the medicinal material cooked in step (2) to ferment as catalyst, dry after fermentation spare；
(4) dregs of a decoction are filtered off after being soaked for a period of time the medicinal material dried in step (3) with alcohol and obtain filtrate, evaporated under reduced pressure arrives
Paste is the plant extracts relieved pain.
7. the plant extracts preparation method of analgesic according to claim 6, it is characterised in that component in the step (1)
It smashes to 20-60 mesh sizes, cassia twig, drooping stringbush flower root and bark, ramulus mori, spina gleditsiae, frutus cnidii, Radix Angelicae Pubescentis, radish described in the step (2)
Son, Radix Angelicae Sinensis, teasel root, RADIX CURCUMAE, turmeric, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae, the root of Chinese clematis, caulis trachelospermi, Radix Astragali, Fructus Corni and paenoiae alba are
It nourishes class or the advanced row of rhizome constituents steams.
8. the plant extracts preparation method of analgesic according to claim 6, it is characterised in that red yeast rice in the step (3)
The amount of addition is 1/4 to the 1/3 of the weight of the medicinal material cooked, and fermentation temperature is in 36-39 degree, and the red yeast rice is the same as Radix Notoginseng powder one
With addition.
9. the plant extracts preparation method of analgesic according to claim 6, it is characterised in that the wine in the step (3)
Essence, including the concentration that do not ferment are more than or equal to 95% alcohol and alcohol of the concentration more than or equal to 75% of fermentation, the leaching
For bubble to cover immersion, it is 4-8 hours to impregnate.
10. the plant extracts preparation method of analgesic according to claim 6, it is characterised in that step (4) decompression
It is negative pressure 0.08pa, temperature 55-60 degree to be evaporated condition.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116509987A (en) * | 2023-07-03 | 2023-08-01 | 北京盛际中医药研究院 | Traditional Chinese medicine composition for removing blood stasis, dispelling cold Shu Gong and relieving pain as well as preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107812086A (en) * | 2017-12-07 | 2018-03-20 | 杨熙筠 | A kind of Chinese medicine of analgesic, include its medicinal liquor and preparation method thereof |
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2018
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107812086A (en) * | 2017-12-07 | 2018-03-20 | 杨熙筠 | A kind of Chinese medicine of analgesic, include its medicinal liquor and preparation method thereof |
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| 刘咏华: "活络效灵丹临证举隅", 《辽宁中医学院学报》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116509987A (en) * | 2023-07-03 | 2023-08-01 | 北京盛际中医药研究院 | Traditional Chinese medicine composition for removing blood stasis, dispelling cold Shu Gong and relieving pain as well as preparation method and application thereof |
| CN116509987B (en) * | 2023-07-03 | 2023-10-13 | 北京盛际中医药研究院 | Traditional Chinese medicine composition for removing blood stasis, dispelling cold Shu Gong and relieving pain as well as preparation method and application thereof |
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