CN109528852A - A kind of Chinese medicine composition and preparation method thereof for treating young pig blue-ear disease - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating young pig blue-ear disease Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of Chinese medicine composition for treating young pig blue-ear disease and its application.The traditional chinese medicine composition of the invention includes the coptis, scutellaria, Cortex Phellodendri, cape jasmine and Radix Astragali.Above-mentioned gomi herbs is carried out reasonable compatibility by the present invention, by the collective effect of each active ingredient of Chinese herbs, obtained Chinese medicine composition, which has blue otopathy poison, significantly inhibits effect, young pig blue-ear disease antibody level can be effectively improved, to the cure rate of young pig blue-ear disease up to 81% or more, significantly reduces pig production cost, improve disease syndrome prevention and control ability, the competitiveness of meat product is improved, and can promote pig breeding industry health, sustainable development, there are potential economical, societal benefits.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of Chinese medicine composition for treating young pig blue-ear disease and its answer
With.
Background technique
Blue otopathy, also known as " mystery swine disease ", " new swine disease ", " pig Epidemic abortion ", " breathing syndrome ", " pig breeding with
Breathing syndrome " and " swine fever epidemic disease " etc. are a kind of highly contagious diseases as caused by PRRS virus, and there is height to pass
Metachromia and lethal, China are classified as two class infectious diseases.The pig of various kinds, all ages and classes and purposes can infect the disease, and 1
Piglet within monthly age is most susceptible.It is characterized in that: morbidity newborn piglet mainly shows expiratory dyspnea, the diseases such as ataxia and paresis
Shape.This disease can occur throughout the year, be to endanger one of principal disease of pig breeding industry.
It is mainly prevented and treated at present using vaccine injection, such as penicillin, streptomysin, tetracycline, sulphadiazine are anti-
Rhzomorph, the injections such as antiviral agent such as folium isatidis, Radix Isatidis.In addition, having document report I type interferon, type iii interferon, for rice
Examine star, IL-12 and N- N-acetylpenicillamine has and has inhibiting effect to PRRSV.The researchs such as Kim and Lee find Ribavirin energy
Enough duplications for inhibiting PRRSV in vitro have certain curative effect to blue otopathy.But it is slow that these drugs will lead to immunity, and
Maintain immunization time short, toxic side effect is larger, and high production cost.And existing Chinese medicine preparation forms complex, effect mostly
Also undesirable, such as it is reported in the literature by polygonum cuspidate, Radix Astragali, aizoon stonecrop, Sculellaria barbata, 10 taste Chinese medicinal composition of myrobalan Chinese medicine compound prescription
Extract has the effect of certain anti-PRRSV, but the effect is unsatisfactory, and the total effective rate to blue otopathy is 73%.Therefore, compel
Being essential will provide that a kind of constituent is few, and have the drug of significant curative effect and Small side effects to porcine reproductive and respiratory syndrome.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of Chinese medicine composition for treating young pig blue-ear disease and its preparation sides
Method enables the composition effectively to treat and prevent female young pig blue-ear disease, and Small side effects.
In order to achieve the object of the present invention, the present invention adopts the following technical scheme:
The present invention provides a kind of Chinese medicine compositions for treating pig blue-ear disease, including the coptis, scutellaria, Cortex Phellodendri, cape jasmine and Huang
Stilbene.
The coptis, scutellaria, Cortex Phellodendri, cape jasmine and Radix Astragali gomi herbs are carried out reasonable compatibility by the present invention, by each active Chinese drug component
The collective effect of ingredient, obtained Chinese medicine composition, which has blue otopathy poison, significantly inhibits effect, can effectively improve piglet indigo plant
Otopathy antibody level, to the cure rate of young pig blue-ear disease up to 81% or more.
Preferably, in parts by weight, the parts by weight of each raw material in the traditional chinese medicine composition of the invention are as follows:
5~11 parts of the coptis, 12~16 parts of scutellaria, 4~10 parts of Cortex Phellodendri, 5~12 parts of cape jasmine, 6~10 parts of Radix Astragali.
In certain embodiments, each raw material weight number are as follows: 8 parts of the coptis, 14 parts of scutellaria, 7 parts of Cortex Phellodendri, cape jasmine 8.5
Part, 8 parts of Radix Astragali.
In other specific embodiments, each raw material weight number are as follows:
5 parts of the coptis, 12 parts of scutellaria, Cortex Phellodendri 10,12 parts of cape jasmine, 6 parts of Radix Astragali；
Or, 11 parts of the coptis, 16 parts of scutellaria, 4 parts of Cortex Phellodendri, 5 parts of cape jasmine, 10 parts of Radix Astragali.
The present invention passes through antibody level detection test and clinical application development test, it was demonstrated that the traditional chinese medicine composition of the invention
Young pig blue-ear disease antibody level can be effectively improved, to the cure rate of young pig blue-ear disease up to 81% or more, significant effect is better than
Control group Chinese medicine composition.Show that Chinese medicine composition provided by the invention there is significant treat and prevent to make young pig blue-ear disease
With.Therefore, the application the present invention provides the Chinese medicine composition in preparation treatment piglet indigo plant otopathy drug.
The present invention also provides the preparation methods of the Chinese medicine composition, and the coptis, scutellaria, Cortex Phellodendri, cape jasmine and Radix Astragali is former
Material forms Ultramicro-powder through Ultramicro-powder machine, is uniformly mixed.
The present invention also provides a kind of pharmaceutical preparations for treating young pig blue-ear disease, include the traditional chinese medicine composition of the invention and auxiliary material.
Those skilled in the art can be made according to the auxiliary material that different dosage forms are required various pharmaceutically routines is prepared according to common process
Different dosage forms, such as pulvis, injection.
Chinese medicine composition provided by the invention includes the coptis, scutellaria, Cortex Phellodendri, cape jasmine and Radix Astragali, and the present invention is by the above-mentioned five tastes
Medicinal material carries out reasonable compatibility, and by the collective effect of each active ingredient of Chinese herbs, obtained Chinese medicine composition has blue otopathy poison
Effect is significantly inhibited, young pig blue-ear disease antibody level can be effectively improved, to the cure rate of young pig blue-ear disease up to 81% or more, effect
Fruit is significantly higher than control group Chinese medicine composition, significantly reduces pig production cost, improves disease syndrome prevention and control ability, improves
The competitiveness of meat product, and can promote pig breeding industry health, sustainable development, there are potential economical, societal benefits.
Specific embodiment
The invention discloses a kind of Chinese medicine composition and preparation method thereof for treating young pig blue-ear disease, those skilled in the art
Present disclosure can be used for reference, realization of process parameters is suitably modified.In particular, it should be pointed out that all similar substitutions and modifications pair
It is it will be apparent that they are considered as being included in the present invention for those skilled in the art.Method and application of the invention is
Through being described by preferred embodiment, related personnel obviously can not depart from the content of present invention, in spirit and scope to this
Methods and applications described in text are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
To the explanation of the disclosed embodiments, enable those skilled in the art to implement or use the present invention.To this
A variety of modifications of a little embodiments will be readily apparent to those skilled in the art, as defined herein general
Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, the present invention will not
It can be intended to be limited to the embodiments shown herein, and be to fit to consistent with the principles and novel features disclosed in this article
Widest scope.
The test material that the present invention uses is all common commercially available product, can all be bought in market.
Below with reference to embodiment, the present invention is further explained:
The preparation of 1 present composition of embodiment
Composition: 8 parts of the coptis, 14 parts of scutellaria, 7 parts of Cortex Phellodendri, 8.5 parts of cape jasmine, 8 parts of Radix Astragali.
Preparation method: the coptis, scutellaria, Cortex Phellodendri, cape jasmine and Radix Astragali mixing are weighed, directly by the coptis, scutellaria, Cortex Phellodendri, cape jasmine
Ultramicro-powder, which is formed, through Ultramicro-powder machine with Radix Astragali mixed raw material obtains the present composition.
The preparation of 2 present composition of embodiment
Composition: 5 parts of the coptis, 12 parts of scutellaria, Cortex Phellodendri 10,12 parts of cape jasmine, 6 parts of Radix Astragali.
The preparation method is the same as that of Example 1.
The preparation of 3 present composition of embodiment
Composition: 11 parts of the coptis, 16 parts of scutellaria, 4 parts of Cortex Phellodendri, 5 parts of cape jasmine, 10 parts of Radix Astragali.
The preparation method is the same as that of Example 1.
The clinical research test of 4 present composition of embodiment
Example 1 group: 1 Chinese medicine composition of the embodiment of the present invention: 8 parts of the coptis, 17 parts of scutellaria, 7 parts of Cortex Phellodendri, 8.5 parts of cape jasmine,
10 parts of Radix Astragali.
2 groups of embodiment: 2 Chinese medicine composition of the embodiment of the present invention: 5 parts of the coptis, 14 parts of scutellaria, Cortex Phellodendri 10,12 parts of cape jasmine, Huang
8 parts of stilbene.
1 group of comparative example: 8 parts of the coptis, 17 parts of scutellaria, 7 parts of Cortex Phellodendri, 8.5 parts of cape jasmine.
2 groups of comparative example: 5 parts of the coptis, Cortex Phellodendri 10,12 parts of cape jasmine, 8 parts of Radix Astragali, 8 parts of gypsum.
Choose different regions, different scales, Various Seasonal natural infection HP-PRRSV morbidity pig farm, with 400 fall ill
Piglet is research object, and for weight in 35~40kg, stochastic averagina is divided into four groups, is fed by above-mentioned processing group, continuous feeding 5 days,
Period observes sick pig symptom daily, to the weighing of dead pig, anatomic observation pathology, and notes down, and solves after 7 days to not dead pig
It cuts open, records lesion situation, count the death rate and cure rate, occur pig blue-ear disease symptom during test and death is that infection is dead
It dies, not dead and dissection is to cure without blue otopathy symptom after the test, the results are shown in Table 1.
Table 1
The results show that 1~2 group of the embodiment of the present invention cure rate to young pig blue-ear disease is up to 81% or more, with comparative example 1~
2 groups compared to significant difference.
The Chinese medicine composition of Example 3 carries out above-mentioned test, is 82% through statistics cure rate.
Long term toxicity test of 5 present composition of embodiment to illness piglet
Illness piglet 100 for choosing 60 ages in days, weight are 35~40kg, feed 1~3 Chinese traditional medicine composition of the embodiment of the present invention
Object, long term administration in 12 weeks, detected the indexs such as piglet general status, growth and development, blood routine, hepatic and renal function after 12 weeks,
It is showed no abnormal change, pathology detection has no pathological change.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating young pig blue-ear disease, which is characterized in that in parts by weight, comprising:
5~11 parts of the coptis, 12~16 parts of scutellaria, 4~10 parts of Cortex Phellodendri, 5~12 parts of cape jasmine, 6~10 parts of Radix Astragali.
2. Chinese medicine composition according to claim 1, which is characterized in that in parts by weight, the parts by weight of each raw material are as follows:
8 parts of the coptis, 14 parts of scutellaria, 7 parts of Cortex Phellodendri, 8.5 parts of cape jasmine, 8 parts of Radix Astragali.
3. Chinese medicine composition according to claim 3, which is characterized in that in parts by weight, the parts by weight of each raw material are as follows:
5 parts of the coptis, 12 parts of scutellaria, Cortex Phellodendri 10,12 parts of cape jasmine, 6 parts of Radix Astragali.
4. Chinese medicine composition according to claim 2, which is characterized in that in parts by weight, the parts by weight of each raw material are as follows:
11 parts of the coptis, 16 parts of scutellaria, 4 parts of Cortex Phellodendri, 5 parts of cape jasmine, 10 parts of Radix Astragali.
5. application of the Chinese medicine composition described in claim 1-4 any one in preparation treatment piglet indigo plant otopathy drug.
6. the preparation method of Chinese medicine composition described in Claims 1 to 4 any one, which is characterized in that by the coptis, scutellaria, Huang
Cypress, cape jasmine and Radix Astragali mixing, obtain the Chinese medicine composition through water extract-alcohol precipitation.
7. a kind of pharmaceutical preparation for treating young pig blue-ear disease, which is characterized in that include any one of the Claims 1 to 5 Chinese medicine
Composition and auxiliary material.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910097528.8A CN109528852A (en) | 2019-01-31 | 2019-01-31 | A kind of Chinese medicine composition and preparation method thereof for treating young pig blue-ear disease |
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| CN201910097528.8A CN109528852A (en) | 2019-01-31 | 2019-01-31 | A kind of Chinese medicine composition and preparation method thereof for treating young pig blue-ear disease |
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| CN201910097528.8A Pending CN109528852A (en) | 2019-01-31 | 2019-01-31 | A kind of Chinese medicine composition and preparation method thereof for treating young pig blue-ear disease |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455749A (en) * | 2008-11-25 | 2009-06-17 | 洛阳市康一生物科技有限公司 | Combination method of heat-clearing and antitoxic medicine |
| CN106511570A (en) * | 2016-12-22 | 2017-03-22 | 重庆西农大科信动物药业有限公司 | Herbal powder used for porcine circovirus and/or porcine reproductive and respiratory syndrome, and preparation method and application thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455749A (en) * | 2008-11-25 | 2009-06-17 | 洛阳市康一生物科技有限公司 | Combination method of heat-clearing and antitoxic medicine |
| CN106511570A (en) * | 2016-12-22 | 2017-03-22 | 重庆西农大科信动物药业有限公司 | Herbal powder used for porcine circovirus and/or porcine reproductive and respiratory syndrome, and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
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| 张洪培等: "中药复方对蓝耳和圆环病毒的清除试验", 《中兽医学杂志》 * |
| 陈晓兰等: "抗猪病毒性疾病中兽药的研究进展", 《黑龙江畜牧兽医》 * |
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