CN109528778A - It is a kind of for increasing the monkey mushroom broken wall medicine materical crude slice and preparation method thereof of immunity and anti-aging - Google Patents
It is a kind of for increasing the monkey mushroom broken wall medicine materical crude slice and preparation method thereof of immunity and anti-aging Download PDFInfo
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Abstract
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, disclose a kind of for increasing the monkey mushroom broken wall medicine materical crude slice and preparation method thereof of immunity and anti-aging.This method comprises: being the particle of 40-100 mesh by dry monkey mushroom medicinal material precomminution to granularity, obtained monkey mushroom herb in granule form is added in the ethanol water that concentration is 30-40 weight % and is impregnated, filtering, obtained filter cake is freeze-dried, the monkey mushroom particle obtained after freeze-drying is subjected to microwave treatment under vacuum conditions, then it is pulverized, obtained micropowders is mixed with the ethanol water that concentration is 50-60 weight % later, is then pelletized and is dried.The higher monkey mushroom broken wall medicine materical crude slice of broken wall ratio can be made using method of the present invention.
Description
Technical field
The present invention relates to Chinese medicine wall cell disruption medicine materical crude slice technical fields, and in particular to a kind of for increasing the monkey of immunity and anti-aging
Mushroom broken wall medicine materical crude slice and preparation method thereof.
Background technique
Chinese medicine wall cell disruption medicine materical crude slice be with modern superfine communication technique by traditional medicine materical crude slice be process it is a kind of in powder form
The prepared slices of Chinese crude drugs being used as medicine.Chinese medicine wall cell disruption medicine materical crude slice is that full ingredient is used as medicine, and medical substance basis is constant, meets the intension of the prepared slices of Chinese crude drugs,
The nature and flavor of medicine materical crude slice and channel tropism after broken wall, function keep consistent with the tradition property of medicine materical crude slice with curing mainly etc., and broken wall medicine materical crude slice can be straight
It connects to brew and take, can be taken together with the dregs of a decoction.But medicine materical crude slice manufacturing enterprise applies not broken wall medicine materical crude slice technology at home at present
Extensively, real industry standard is not formed yet.Therefore, a kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice is researched and developed, sufficiently
The advantage that the full ingredient of Chinese medicine wall cell disruption medicine materical crude slice is used as medicine is played, whole effective components of traditional Chinese medicine are retained by broken wall, and then more sharp
In absorption of the user to effective component, is extracted with alleviating after existing Chinese medicine particle adds water to be concentrated, Chinese medicine part can only be extracted
The problem of effective component, becomes very necessary and urgent.
Monkey mushroom is russule mesh hedgehog hydnum Cordycepps Hericium erinaceus (Hericium erinaceus (Rull ex F.) Pers.), is belonged to
Basidiomycetes is a kind of saprophytic bacteria.Monkey mushroom is a kind of fungi of dual-purpose of drug and food, mild-natured, and sweet in flavor, relieving the five internal organs are aid digestion, is grown
It mends, anticancer, treatment neurasthenia.Its main active is unsaturated fatty acid, polysaccharide, amino acid etc..With antiulcer, resist
Scorching, antitumor, liver protecting increases immunity, anti-aging, improves body's hypoxia tolerance, increase heart blood output quantity, add
Fast body blood circulation reduces the effect of blood glucose and blood lipid.However, there is presently no about monkey mushroom broken wall medicine materical crude slice and its preparation
The report of technique.
Summary of the invention
The monkey mushroom broken wall medicine materical crude slice and its preparation that the object of the present invention is to provide a kind of for increasing immunity and anti-aging
Method.
The present invention provides a kind of for increasing the preparation method of the monkey mushroom broken wall medicine materical crude slice of immunity and anti-aging, the party
Method includes: the particle by dry monkey mushroom medicinal material precomminution to granularity for 40-100 mesh, the monkey mushroom herb in granule form that will be obtained
It is added in the ethanol water that concentration is 30-40 weight % and impregnates, filter, obtained filter cake is freeze-dried, will be freeze-dried
The monkey mushroom particle obtained afterwards carries out microwave treatment under vacuum conditions, is then pulverized, the ultra micro that will be obtained later
Fine powder is mixed with the ethanol water that concentration is 50-60 weight %, is then pelletized and is dried.
The present invention also provides the monkey mushroom broken wall medicine materical crude slice prepared by the above method.
According to the preparation method of monkey mushroom broken wall medicine materical crude slice of the present invention, monkey mushroom medicinal material is subjected to precomminution first,
Then it successively impregnated, be freeze-dried, stored frozen and microwave treatment, a whole set for the treatment of process in this way can be to monkey mushroom
Cell wall carry out embrittlement, then by pulverize can easily make monkey mushroom breaking-wall cell, to obtain broken wall ratio
Higher monkey mushroom broken wall medicine materical crude slice.Moreover, the product composition of the monkey mushroom broken wall medicine materical crude slice prepared according to the method described in the present invention
Consistency is preferable, and quality is stable, controllable, is conducive to modern big industrialized development significantly.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of monkey mushroom broken wall medicine materical crude slice of the present invention includes: by dry monkey mushroom medicinal material precomminution to grain
Degree is the particle of 40-100 mesh, obtained monkey mushroom herb in granule form is added in the ethanol water that concentration is 30-40 weight %
It impregnates, obtained filter cake is freeze-dried, the monkey mushroom particle obtained after freeze-drying is carried out under vacuum conditions micro- by filtering
Wave processing, is then pulverized, and later mixes obtained micropowders for the ethanol water of 50-60 weight % with concentration
It closes, is then pelletized and dried.
In method of the present invention, by carrying out precomminution to the monkey mushroom medicinal material, monkey mushroom medicinal material is improved
Specific surface area, to be more advantageous to the embrittlement of the processes to monkey mushroom cell wall such as subsequent immersion, freezing and microwave treatment.?
In the present invention, the process of the precomminution is implemented using the grinding device of this field routine, and details are not described herein.
In method of the present invention, monkey mushroom particle is impregnated using the ethanol water of 30-40 weight %,
Be conducive to carry out embrittlement to monkey mushroom cell wall, to help to obtain the monkey mushroom broken wall medicine materical crude slice of high sporoderm-broken rate.
In method of the present invention, the condition of immersion may include: that temperature is 50-80 DEG C of (such as 50 DEG C, 60 DEG C, 70
DEG C or 80 DEG C), the time be 1-3 hours (such as 1 hour, 1.5 hours, 2 hours, 2.5 hours or 3 hours).In the present invention, pass through
It impregnates monkey mushroom particle at a relatively high temperature, then carries out freezing processing at very low temperature, so that monkey
Mushroom cell is exposed under the larger temperature difference, is conducive to carry out embrittlement to monkey mushroom cell wall in this way, to help to obtain height
The monkey mushroom broken wall medicine materical crude slice of sporoderm-broken rate.
In method of the present invention, during the immersion, the volume of monkey mushroom particle and ethanol water
Than that can be 1:2-10, preferably 1:3-8, more preferably 1:3-5.
In method of the present invention, the condition of freeze-drying may include: that temperature is -5 DEG C~-30 DEG C, vacuum degree
For 5-50Pa.Herein, vacuum degree refers to absolute pressure.
In method of the present invention, filtering can use the strainer filtering of this field routine.In specific embodiment party
In formula, the strainer can be the stainless steel cloth that mesh size is 200 mesh.
In method of the present invention, the condition of microwave treatment may include: that temperature is 10-40 DEG C, preferably 20-30
℃；Time is 30-60min, preferably 30-40min；The power of microwave is 5-20kW, preferably 10-20kW；Vacuum degree is 5-
50Pa, preferably 10-20Pa.
In method of the present invention, it is preferable that the process of the ultramicro grinding, which crushes the monkey mushroom particle, is
The micropowders of 40 microns or less (preferably 5-40 microns, more preferably 5-30 microns).Equipment used in pulverizing can
Wall-broken grinder is thought, such as CW5-100QA broken wall micronizer.
In method of the present invention, during micropowders are mixed with ethanol water, the micropowders
Mixing mass ratio with the ethanol water is 1:0.6-0.8.
In method of the present invention, the method for the drying can be contact drying, pneumatic conveying drying, tunnel type baking oven
Drying, vacuum drying, fluidized drying, freeze-drying, far-infrared ray drying or microwave drying.In the preferred case, the drying
Method is freeze-drying.
The present invention also provides the monkey mushroom broken wall medicine materical crude slice prepared by the above method.
The present invention will be described in detail by way of examples below.
Embodiment 1
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 80 mesh, are subsequently added into monkey mushroom particle 4
The ethanol solution of 35 weight % of times volume, impregnates 2 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 55 weight % it is that 1:0.7 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A1 be made.
Embodiment 2
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 40 mesh, are subsequently added into monkey mushroom particle 5
The ethanol solution of 30 weight % of times volume, impregnates 1 hour at 80 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 50 weight % it is that 1:0.8 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A2 be made.
Embodiment 3
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 100 mesh, are subsequently added into monkey mushroom particle 3
The ethanol solution of 40 weight % of times volume, impregnates 1 hour at 50 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 60 weight % it is that 1:0.6 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A3 be made.
Embodiment 4
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 50 mesh, are subsequently added into monkey mushroom particle 4
The ethanol solution of 30 weight % of times volume, impregnates 2 hours at 65 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 54 weight % it is that 1:0.6 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A4 be made.
Embodiment 5
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 80 mesh, are subsequently added into monkey mushroom particle 5
The ethanol solution of 35 weight % of times volume, impregnates 3 hours at 55 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 52 weight % it is that 1:0.7 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A5 be made.
Embodiment 6
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 50 mesh, are subsequently added into monkey mushroom particle 3
The ethanol solution of 38 weight % of times volume, impregnates 2 hours at 60 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 58 weight % it is that 1:0.5 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A6 be made.
Embodiment 7
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 60 mesh, are subsequently added into monkey mushroom particle 4
The ethanol solution of 30 weight % of times volume, impregnates 3 hours at 70 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 51 weight % it is that 1:0.6 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A7 be made.
Embodiment 8
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 50 mesh, are subsequently added into monkey mushroom particle 5
The ethanol solution of 35 weight % of times volume, impregnates 2 hours at 80 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 53 weight % it is that 1:0.7 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A8 be made.
Embodiment 9
The monkey mushroom medicinal material for taking 2.0kg dry, precomminution to granularity are the particle of 80 mesh, are subsequently added into monkey mushroom particle 3
The ethanol solution of 8 weight % of times volume, impregnates 2 hours at 60 DEG C, with the stainless steel wire net filtration of 200 mesh, by what is obtained
Filter cake is freeze-dried at -10 DEG C, under 30Pa vacuum degree.Obtained monkey mushroom particle is placed under vacuum condition and carries out microwave
Processing, the condition of microwave treatment are as follows: temperature is 25 DEG C, time 45min, and the power of microwave is 15kW, vacuum degree 30Pa.With
CW5-100QA broken wall micronizer pulverizes obtained monkey mushroom particle, obtain granularity be 5-30 micron surpass
Fine powder.With the ethanol water that concentration is 57 weight % it is that 1:0.7 is mixed with weight ratio by the micropowders, squeezes out
Granulation, is then freeze-dried at -10 DEG C, under 30Pa vacuum degree, so that monkey mushroom broken wall medicine materical crude slice sample A9 be made.
Comparative example 1
Monkey mushroom broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that not implementing ethanol water immersion
Process, so that monkey mushroom broken wall medicine materical crude slice sample D1 be made.
Comparative example 2
Monkey mushroom broken wall medicine materical crude slice is prepared according to the method for embodiment 1, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made monkey mushroom broken wall medicine materical crude slice sample D2.
Comparative example 3
Monkey mushroom broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that not implementing ethanol water immersion
Process, so that monkey mushroom broken wall medicine materical crude slice sample D3 be made.
Comparative example 4
Monkey mushroom broken wall medicine materical crude slice is prepared according to the method for embodiment 2, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made monkey mushroom broken wall medicine materical crude slice sample D4.
Comparative example 5
Monkey mushroom broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that not implementing ethanol water immersion
Process, so that monkey mushroom broken wall medicine materical crude slice sample D5 be made.
Comparative example 6
Monkey mushroom broken wall medicine materical crude slice is prepared according to the method for embodiment 3, the difference is that being replaced with the mode of natural air drying cold
Be lyophilized it is dry, thus be made monkey mushroom broken wall medicine materical crude slice sample D6.
Test case
The non-broken cells limit of monkey mushroom broken wall medicine materical crude slice is tested with the following method: taking monkey mushroom broken wall medicine materical crude slice
0.1g adds chloraldurate aqueous solution (volume ratio of chloraldurate test solution and water is 1:1) 10ml to be placed on glass slide, and load is set
In microscopically observation, under 10 × 10 times of visuals field, greater than 100 microns and the powder number of complete cell is 0-5.Test
As a result as shown in table 1 below.
Table 1
Can be seen that by the result of table 1 can be made the higher monkey mushroom of broken wall ratio using method of the present invention
Bacterium broken wall medicine materical crude slice.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (8)
1. a kind of for increasing the preparation method of the monkey mushroom broken wall medicine materical crude slice of immunity and anti-aging, which is characterized in that this method
Include: the particle by dry monkey mushroom medicinal material precomminution to granularity for 40-100 mesh, obtained monkey mushroom herb in granule form is added
Enter and impregnated in the ethanol water that concentration is 30-40 weight %, filtered, obtained filter cake is freeze-dried, after freeze-drying
Obtained monkey mushroom particle carries out microwave treatment under vacuum conditions, is then pulverized, ultra tiny by what is obtained later
Powder is mixed with the ethanol water that concentration is 50-60 weight %, is then pelletized and is dried.
2. the time is 1-3 hours the method according to claim 1, wherein the temperature impregnated is 50-80 DEG C.
3. method according to claim 1 or 2, which is characterized in that the condition of freeze-drying include: temperature be -5 DEG C~-
30 DEG C, vacuum degree 5-50Pa.
4. method according to claim 1 or 2, which is characterized in that the condition of microwave treatment includes: that temperature is 10-40 DEG C,
Time is 30-60min, and the power of microwave is 5-20kW, vacuum degree 5-50Pa.
5. method according to claim 1 or 2, which is characterized in that the process of the ultramicro grinding is by the monkey mushroom
It is 40 microns of micropowders below that grain, which crushes,.
6. method according to claim 1 or 2, which is characterized in that in the process that micropowders are mixed with ethanol water
In, the mixing mass ratio of the micropowders and the ethanol water is 1:0.6-0.8.
7. method according to claim 1 or 2, which is characterized in that the drying mode after granulation is freeze-drying.
8. the monkey mushroom broken wall medicine materical crude slice of the preparation of the method as described in any one of claim 1-7.
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| CN101768554A (en) * | 2008-12-31 | 2010-07-07 | 胡如军 | Technological method for breaking cell walls of ganoderma lucidum spore powder |
| CN102846698A (en) * | 2012-08-20 | 2013-01-02 | 浙江中医药大学中药饮片有限公司 | Wall-broken radix tetrastigme oral decoction pieces |
| CN105211847A (en) * | 2015-10-23 | 2016-01-06 | 苏春培 | The preparation method of Hericium erinaceus conidia powder |
| CN107019718A (en) * | 2017-03-15 | 2017-08-08 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of Radix Codonopsis broken wall medicine materical crude slice |
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Application publication date: 20190329 |