CN109512682A - A kind of multiple-phase emulsion, preparation method and its application with protection natural water-soluble colorants function - Google Patents
A kind of multiple-phase emulsion, preparation method and its application with protection natural water-soluble colorants function Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
Abstract
The present invention is a kind of multiple-phase emulsion, preparation method and its application with protection natural water-soluble colorants function.Multiple-phase emulsion of the present invention is made of w/o type first phase and outer aqueous phase, and w/o type first phase includes natural water-soluble colorants solution, w/o type emulsifier and oil phase thickeners, and outer aqueous phase includes O/W type emulsifier and water phase thickener.Natural water-soluble colorants are wrapped in inner aqueous phase by multiple-phase emulsion of the present invention, can be avoided destruction of the extraneous factor to natural water-soluble colorants, improve its stability, while system itself can also be with good stability.The preparation method of multiple-phase emulsion of the present invention is simple, has good application prospect in cosmetic field.
Description
Technical field
The invention belongs to cosmetic field, be related to a kind of multiple-phase emulsion with protection natural water-soluble colorants function,
Preparation method and its application.
Background technique
For natural water-soluble colorants from positions such as root, stem, leaf, flower, the fruits of natural plants, most of is anthocyanidin
Class, carotenoids and flavone compound are a kind of biologically active substances, and safety is higher.According to document report
Road, natural water-soluble colorants can not only provide coloration, also have anti-oxidant, improvement eyesight, anticancer, antimutation, weight-reducing, resist
The effects of aging.Therefore, natural water-soluble colorants all have broad application prospects in food, drug and cosmetic industry.
Each position of the natural water-soluble colorants from natural plants, and natural plants are many kinds of, property is complicated, big portion
Point natural plant pigment changes light, heat, oxygen, microorganism, metal and pH value sensitive, and stability is poor, cause its application by
To limitation.Natural water-soluble colorants are applied in the form of microcapsules, liposome, nanometer etc. mostly at present, but its preparation process
Complexity is unfavorable for the production application in cosmetics.Therefore, it is necessary to find a kind of ideal system, day can not only be protected well
Right water colo(u)r, and preparation method also wants fairly simple, in addition, system itself is also required for relatively good stability,
In order to its application and popularization.
Summary of the invention
In order to overcome the disadvantages mentioned above and deficiency of the prior art, the purpose of the present invention is to provide one kind to have protection natural
Multiple-phase emulsion, preparation method and its application of water colo(u)r function.
The object of the invention is achieved through the following technical solutions:
A kind of multiple-phase emulsion with protection natural water-soluble colorants function, it is characterised in that: the multiple-phase emulsion
It is made of w/o type first phase and outer aqueous phase, the mass ratio of the w/o type first phase and outer aqueous phase is 10-80:20-90;
The w/o type first phase includes the w/o type that mass percent is the natural water-soluble colorants of 0.1-80%, 0.1-20%
Emulsifier, the grease of 5-60%, the oil phase thickeners of 0.1-5% and surplus water;
The outer aqueous phase include mass percent be the O/W type emulsifier of 0.1-20%, 0.1-5% water phase thickener and
The water of surplus, the O/W type emulsifier are the mixture of dimethylsiloxane copolymer and caprylic/capric glyceryl ester, spermaceti
The mixture of stearyl olive grease and Olivem 1000, the mixing of 16 octadecyl glucosides and cetostearyl alcohol
Object, the mixture of lauryl glucoside, polyglycereol -2 dimerization hydroxy stearic acid ester and glycerol, cetearyl glucoside and spermaceti
The mixture of stearyl alcohol, PEG-20 methyl glucoside sesquistearate, stereth -21, cetearyl alcohol polyethers -21,
Docosanol ether -25, PEG-7 olive oil carboxylic acid sodium, -6 olive oleate of ceteareth, cetearyl glucoside,
Phosphoric acid monohexadecyl ester DEA salt, cetanol phosphate, Phosphoric acid monohexadecyl ester potassium, ceteareth -20, stearine,
Three (laureth -4) phosphates, PEG-20 tristerin, at least one of cetearyl sodium sulfonate, or in which
At least one mixture formed with tween, the preferably mixture of stereth -21 and polysorbate60.The multiple-phase emulsion
With multiplet, effectively natural water-soluble colorants can be wrapped in inner aqueous phase, avoid extraneous factor to natural water-soluble
The destruction of property pigment, and described multiple-phase emulsion itself has good light durability, smoothness, spreadability and frivolous property,
When O/W type emulsifier is the mixture of stereth -21 and polysorbate60, the multiple-phase emulsion easily forms comparison rule
Multiplet is more advantageous to the protection to natural water-soluble colorants.
Preferably, the mass ratio of the w/o type first phase and outer aqueous phase is 30-70:30-70;
The w/o type first phase includes the w/o type cream that mass percent is the natural water-soluble colorants of 0.1-80%, 2-8%
Agent, the grease of 10-60%, the oil phase thickeners of 0.1-0.5% and surplus water;
The outer aqueous phase includes that mass percent is the O/W type emulsifier of 1-8%, the water phase thickener of 0.1-1% and remaining
The water of amount.With this condition, the multiplet quantity of multiple-phase emulsion is relatively more, and partial size is smaller, can preferably wrap up natural
Water colo(u)r, so as to preferably protect natural water-soluble colorants.
Preferably, the w/o type emulsifier is ring five dimethyl silicone polymer and PEG/PPG-20/15 polydimethylsiloxanes
The mixture of alkane, the mixture of ring five dimethyl silicone polymer and PEG/PPG-18/18 dimethyl silicone polymer, the poly- diformazan of ring five
The mixture of radical siloxane and PEG-12 Dimethicone Crosspolymer, the smooth sesquialter oil of isosteareth -2, sorb
The mixture of acid esters and cetyl PEG/PPG-10/1 dimethyl silicone polymer, sapn, -2 dimerization hydroxy stearic acid ester of polyglycereol,
Polyglyceryl-3 diisostearate, -3 polyricinoleate of polyglycereol, PEG-10 Polydimethylsiloxane, lauryl PEG-10 tri-
(trimethylsiloxy group) silica ethyl polymethyl siloxane, the smooth tristearate of sorb, the smooth oleate of sorb, the smooth sesquialter oleic acid of sorb
The mixture of ester and the smooth trioleate of sorb, PEG-8 dimethyl silicone polymer, double-isobutyl group PEG/PPG-10/7/ poly dimethyl
Silicone copolymers, Polydimethylsiloxane PEG-10/15 Crosslinked Polymer, -2 sesquioleate of polyglycereol, PEG-30 dimerization
Hydroxy stearic acid ester, the smooth olive oleate of sorb, PEG-9 dimethyl silicone polymer, lauryl PEG/PPG-18/18 poly dimethyl
Siloxanes, at least one of cetyl PEG/PPG-10/1 dimethyl silicone polymer, preferably cetyl PEG/PPG-10/1
Dimethyl silicone polymer.When using these substances as w/o type emulsifier, the multiple-phase emulsion not only has good illumination steady
It is qualitative, also there is good heat resistance and cold resistance, the multiple-phase emulsion structure of formation is more regular, especially with cetyl PEG/
When PPG-10/1 dimethyl silicone polymer is as w/o type emulsifier, the multiplet of the easy formation rule of multiple-phase emulsion, energy
Preferably protect natural water-soluble colorants.
Preferably, the oil phase thickeners are trihydroxy stearate, aluminium/magnesium hydroxide tristearin acid complex, modification
At least one of montmorillonite, preferably modified montmorillonoid.Using these substances as oil phase thickeners, it can suitably slow down w/o type
Interparticle collision in first phase is made multiple-phase emulsion have relatively good stability, is especially mutually thickened using modified montmorillonoid as oily
The stability of agent, multiple-phase emulsion is more preferable.
Preferably, the grease be caprylic/capric triglyceride, it is isopropyl myristate, saualane, triglycerides, different
At least one of different nonyl ester of n-nonanoic acid, the preferably mixture of caprylic/capric triglyceride and isopropyl myristate.When described
It when grease is these substances, does not need to carry out heating melt processed to grease, can avoid natural water-soluble colorants grease is added
Destruction of the high temperature to it when middle, when the grease is the mixture of caprylic/capric triglyceride and isopropyl myristate, also
Be conducive to the formation of multiple-phase emulsion multiplet.
Preferably, the water phase thickener be acrylic acid polymer, it is hydroxyethyl cellulose, guar gum, xanthan gum, bright
Glue, hydroxypropyl starch phosphate, guar gum hydroxypropyl-trimethyl ammonium chloride, hectorite, aluminum magnesium silicate, soluble starch, Ah
Draw at least one of uncle's natural gum, sodium alginate, carboxymethyl cellulose, carboxy-propyl cellulose, preferably xanthan gum.With these objects
Matter is conducive to the stabilization of multiple-phase emulsion and the formation of multiplet as water phase thickener.
Preferably, the natural water-soluble colorants are tetrapyrrole derivative, isoprene derivatives, cyanine glycoside derive
At least one of object, ketones derivant, naphthoquinone derivatives, caramel colorant, the tetrapyrrole derivative are chlorophyll, chlorophyll
At least one of copper sodium, ferroheme, the isoprene derivatives be capsanthin, Gardenia Yellow, in beta carotene at least
One kind, the anthocyanin analog derivative is more Exocarpium Citri Rubrum, Grape Skin is red, roselle is red, radish red, beet red, red in sweet potato, semen sojae atricolor
Red, mulberry fruit is at least one of red, the ketones derivant be curcumin, monascorubin, safflower yellow, in Cacao pigment extremely
Few one kind, the naphthoquinone derivatives at least one of red, alkermes for lac.
Preferably, the mass ratio of the w/o type first phase and outer aqueous phase is 30:70;
The w/o type first phase include mass percent be 5% cetyl PEG/PPG-10/1 dimethyl silicone polymer,
10% caprylic/capric triglyceride, 10% isopropyl myristate and 0.3% modified montmorillonoid;
The outer aqueous phase include mass percent be 0.5% xanthan gum, 1% stereth -21 and 1% tween
60.Under this condition, the multiplet of multiple-phase emulsion is regular circle, and average grain diameter is about 10 μm, and system stability is good
It is good, it can very well protect water-soluble color.
The present invention also provides the preparation method of the multiple-phase emulsion, the preparation method includes the following steps:
(1) first by w/o type emulsifier, grease and oil phase thickeners under 3000-5000rpm homogeneous 2-4min, obtain oil
Phase;
(2) natural water-soluble colorants solution being slowly added drop-wise in the oily phase, the side Bian Junzhi is added dropwise, after dripping,
Homogeneous 3-7min under the conditions of 4000-6000rpm forms stable W/O emulsion, obtains w/o type first phase;
(3) under conditions of 40-50 DEG C, 200-600rpm, first water phase is uniformly mixed, then by the w/o type first phase by
It is added drop-wise to described just in water phase, drips and be stirred for 20-30min and can be prepared by the multiple-phase emulsion.
The present invention also provides the application of the multiple-phase emulsion, the multiple-phase emulsion can be used to prepare cosmetics, institute
Stating cosmetics includes but is not limited to facial mask, essence, lotion, creme or lipstick.
Compared with prior art, the present invention has the following advantages and beneficial effects:
(1) there is the present invention multiple-phase emulsion of protection natural water-soluble colorants function can wrap up natural water-soluble colorants
In inner aqueous phase, it can avoid destruction of the extraneous factor to natural water-soluble colorants, improve its stability, and multiple-phase emulsion itself
Also with good stability, application easy to spread.
(2) present invention has the preparation method of the multiple-phase emulsion of protection natural water-soluble colorants function easy to operate, item
Part is controllable, is readily produced.
(3) present invention has the multiple-phase emulsion of protection natural water-soluble colorants function smooth, has good spreadability,
It will not feel greasy when use, have a good application prospect in cosmetic field.
Detailed description of the invention
Fig. 1 is the microscopic structure figure of multiple-phase emulsion in embodiment 2;
Fig. 2 is the microscopic structure figure of multiple-phase emulsion in comparative example 3;
Fig. 3 is the microscopic structure figure of emulsion in comparative example 4.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of multiple-phase emulsion with protection natural water-soluble colorants function, ingredient are shown in Table 1.
1 embodiment 1-7 of table has the ingredient and its content/% of the multiple-phase emulsion of protection natural water-soluble colorants function
The preparation method of the multiple-phase emulsion includes the following steps:
(1) first that cetyl PEG/PPG-10/1 dimethyl silicone polymer, caprylic/capric triglyceride, myristic acid is different
Propyl ester and modified montmorillonoid the homogeneous 4min under 3000rpm, obtain oily phase;
(2) after mixing by cyanidin extract aqueous solution and water, it is slowly added drop-wise in the oily phase, the side Bian Junzhi
It is added dropwise, after dripping, homogeneous 7min under the conditions of 4000rpm forms stable W/O emulsion, obtains w/o type first phase;
(3) 40 DEG C, mixing speed be 400rpm under conditions of, by glycerol, xanthan gum, polysorbate60, stereth-
21, Phenoxyethanol and water are uniformly mixed, and obtain just water phase, then the w/o type first phase is added drop-wise to dropwise in the just water phase, drop
It adds and is stirred for 30min and can be prepared by the multiple-phase emulsion.
The multiple-phase emulsion can be used to prepare cosmetics, such as facial mask, essence, lotion, creme, lipstick.
Embodiment 2
A kind of multiple-phase emulsion with protection natural water-soluble colorants function, ingredient are shown in Table 1.
The preparation method of the multiple-phase emulsion includes the following steps:
(1) first that cetyl PEG/PPG-10/1 dimethyl silicone polymer, caprylic/capric triglyceride, myristic acid is different
Propyl ester and modified montmorillonoid the homogeneous 3min under 4000rpm, obtain oily phase;
(2) after mixing by cyanidin extract aqueous solution and water, it is slowly added drop-wise in the oily phase, the side Bian Junzhi
It is added dropwise, after dripping, homogeneous 5min under the conditions of 5000rpm forms stable W/O emulsion, obtains w/o type first phase;
(3) 45 DEG C, mixing speed be 400rpm under conditions of, by glycerol, xanthan gum, polysorbate60, stereth-
21, Phenoxyethanol and water are uniformly mixed, and obtain just water phase, then the w/o type first phase is added drop-wise to dropwise in the just water phase, drop
It adds and is stirred for 25min and can be prepared by the multiple-phase emulsion.
Embodiment 3
A kind of multiple-phase emulsion with protection natural water-soluble colorants function, ingredient are shown in Table 1.
The preparation method of the multiple-phase emulsion includes the following steps:
(1) first that cetyl PEG/PPG-10/1 dimethyl silicone polymer, caprylic/capric triglyceride, myristic acid is different
Propyl ester and modified montmorillonoid the homogeneous 2min under 5000rpm, obtain oily phase;
(2) after mixing by cyanidin extract aqueous solution and water, it is slowly added drop-wise in the oily phase, the side Bian Junzhi
It is added dropwise, after dripping, homogeneous 3min under the conditions of 6000rpm forms stable W/O emulsion, obtains w/o type first phase;
(3) 50 DEG C, mixing speed be 400rpm under conditions of, by glycerol, xanthan gum, stereth -21, benzene oxygen second
Alcohol and water is uniformly mixed, and is obtained just water phase, then the w/o type first phase is added drop-wise to dropwise in the just water phase, is dripped and stir again
Mixing 20min can be prepared by the multiple-phase emulsion.
Embodiment 4-15
It is a kind of multiple-phase emulsion with protection natural water-soluble colorants function, wherein the ingredient of embodiment 4-7 is shown in
The ingredient of table 1, embodiment 8-15 is shown in Table 2.
2 embodiment 8-15 of table has the ingredient and its content/% of the multiple-phase emulsion of protection natural water-soluble colorants function
Embodiment 16
A kind of multiple-phase emulsion with protection natural water-soluble colorants function, ingredient and content are same as Example 1;
Preparation method, in addition to mixing speed is 200rpm in step (3), other are same as Example 1.
Embodiment 17
A kind of multiple-phase emulsion with protection natural water-soluble colorants function, ingredient and content are same as Example 1;
Preparation method, in addition to mixing speed is 600rpm in step (3), other are same as Example 1.
Comparative example 1
A kind of emulsion, except outer aqueous phase is free of stereth -21, other compositions and content are same as Example 1,
The preparation method of the emulsion is also same as Example 1.
Comparative example 2
A kind of emulsion removes and is free of cetyl PEG/PPG-10/1 dimethyl silicone polymer in w/o type first phase, and contains quality
Outside the sorbester p18 that percentage is 5%, other compositions and content are same as Example 1;The preparation method of the emulsion is except step
Suddenly with outside sorbester p18 substitution cetyl PEG/PPG-10/1 dimethyl silicone polymer in (1), other are same as Example 1.
Comparative example 3
A kind of emulsion removes and is free of cetyl PEG/PPG-10/1 dimethyl silicone polymer in w/o type first phase, and contains quality
Outside the PEG-30 dimerization hydroxy stearic acid ester that percentage is 5%, other compositions and content are same as Example 1;The emulsus
The preparation method of liquid is except in addition to PEG-30 dimerization hydroxy stearic acid ester, other are same as Example 1 in step (1).
Comparative example 4
A kind of emulsion, ingredient and content are same as Example 1;Preparation method, except stirring is changed in step (3)
Matter, and homogeneous speed is outside 600rpm, other are same as Example 1.
Comparative example 5
A kind of O/W type emulsion, preparation method are as follows: first by the poly- silicon oxygen of the poly- diformazan of 10g cetyl PEG/PPG-10/1
The isopropyl myristate of alkane, 10g caprylic/capric triglyceride and 10g is uniformly mixed, and obtains oily phase;Again by 0.5g xanthan gum,
1g stereth -21,0.5g polysorbate60,2g glycerol, g pigment and g water are uniformly mixed and obtain water phase;Under the conditions of 4000rpm,
Oil is mutually added drop-wise in water phase in homogeneous, after dripping, then homogeneous 5min under the conditions of 5000rpm, the O/W type can be obtained
Emulsion.
Using the structure of micro- sem observation embodiment 1-17 and comparative example 1-3 emulsion, and to embodiment 1-17 and
Comparative example 1-6 emulsion carries out stability test, i.e., emulsion is respectively placed in 50 DEG C (high temperature), -18 DEG C (low temperature) and nature
Light illumination condition lower 1 month, the variation of emulsion is observed, specific structure and stability test the results are shown in Table 3.
3 test result of table
As shown in Table 3, comparative example 5 is compared, embodiment 1-17 does not change colour under high temperature, low temperature and illumination condition, this
Illustrate the protection natural water-soluble colorants that multiple creamy texture of the invention can be relatively good;Comparative example 1 is compared, embodiment 1-17 can
Form multiplet, and it is stable under illumination condition, this illustrate the multiplet of multiple-phase emulsion formation and system it is steady
It is qualitative related with the type of w/o type emulsifier;Compare embodiment 13,15 multiple-phase emulsion of embodiment 1-12 and embodiment it is multiple
Number of structures is relatively more, compares embodiment 14, the partial size ratio of the multiplet of 15 multiple-phase emulsion of embodiment 1-12 and embodiment
Smaller, this illustrates that the mass ratio of the w/o type first phase and outer aqueous phase is 25-70:30-75, and w/o type first phase includes the W/O of 2-8%
The oil phase thickeners of type emulsifier and 0.1-0.5%, outer aqueous phase include mass percent be 1-8% O/W type emulsifier and
When the water phase thickener of 0.1-1%, multiple-phase emulsion is more preferable to the protecting effect of natural water-soluble colorants, sends out during the test
The mass ratio of existing w/o type first phase and outer aqueous phase is 30-70:30-70, and w/o type first phase includes w/o type emulsifier, the 10- of 2-8%
60% grease and the oil phase thickeners of 0.1-0.5%, outer aqueous phase include mass percent be 1-8% O/W type emulsifier and
When the water phase thickener of 0.1-1%, the formation effect of multiplet is more preferable;Compare comparative example 2 and comparative example 3, embodiment 1-17
Stability under high temperature and cryogenic conditions is more preferable, this illustrates the stabilization for selecting suitable O/W emulsifier to be conducive to system;It compares
Comparative example 4, embodiment 1 and embodiment 16-17 can form multiplet, when this illustrates that w/o type first phase is mixed with water, stirring
Than the formation that homogeneous is more advantageous to multiplet, embodiment 16-17 is furthermore compared, embodiment 1 can form more regular, partial size more
Small multiplet shows the mixing speed too high or too low formation for being unfavorable for multiplet when w/o type first phase is mixed with water.
Centrifugation 30min is carried out under the conditions of 3000rpm to the multiple-phase emulsion of embodiment 1-2, embodiment 1 is layered, but real
It applies example 2 not to be layered, illustrates that the stability of its system is very good.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. it is a kind of with protection natural water-soluble colorants function multiple-phase emulsion, it is characterised in that: the multiple-phase emulsion by
The mass ratio of w/o type first phase and outer aqueous phase composition, the w/o type first phase and outer aqueous phase is 10-80:20-90;
The w/o type first phase includes the w/o type emulsification that mass percent is the natural water-soluble colorants of 0.1-80%, 0.1-20%
Agent, the grease of 5-60%, the oil phase thickeners of 0.1-5% and surplus water;
The outer aqueous phase includes the water phase thickener and surplus that mass percent is the O/W type emulsifier of 0.1-20%, 0.1-5%
Water, the O/W type emulsifier be dimethylsiloxane copolymer and caprylic/capric glyceryl ester mixture, cetearyl alcohol
The mixture of base olive grease and Olivem 1000, the mixture of 16 octadecyl glucosides and cetostearyl alcohol, the moon
The mixture of osmanthus base glucoside, polyglycereol -2 dimerization hydroxy stearic acid ester and glycerol, cetearyl glucoside and cetearyl alcohol
The mixture of alcohol, PEG-20 methyl glucoside sesquistearate, stereth -21, cetearyl alcohol polyethers -21, two ten
Glycol ethers -25, PEG-7 olive oil carboxylic acid sodium, -6 olive oleate of ceteareth, cetearyl glucoside, spermaceti
Alcohol phosphate DEA salt, cetanol phosphate, Phosphoric acid monohexadecyl ester potassium, ceteareth -20, stearine, three
(laureth -4) phosphate, PEG-20 tristerin, at least one of cetearyl sodium sulfonate, or in which extremely
A kind of few mixture formed with tween.
2. multiple-phase emulsion according to claim 1, it is characterised in that: the mass ratio of the w/o type first phase and outer aqueous phase
For 30-70:30-70;
W/o type emulsifier of the w/o type first phase comprising natural water-soluble colorants, 2-8% that mass percent is 0.1-80%,
The water of the grease of 10-60%, the oil phase thickeners of 0.1-0.5% and surplus;
The outer aqueous phase includes that mass percent is the O/W type emulsifier of 1-8%, the water phase thickener of 0.1-1% and surplus
Water.
3. multiple-phase emulsion according to claim 1 or 2, it is characterised in that: the w/o type emulsifier is the poly- diformazan of ring five
The mixture of radical siloxane and PEG/PPG-20/15 dimethyl silicone polymer, ring five dimethyl silicone polymer and PEG/PPG-18/
The mixture of 18 dimethyl silicone polymers, ring five dimethyl silicone polymer and PEG-12 Dimethicone Crosspolymer
Mixture, isosteareth -2, sorbitan sesquioleate and cetyl PEG/PPG-10/1 dimethyl silicone polymer it is mixed
Conjunction object, sapn, -2 dimerization hydroxy stearic acid ester of polyglycereol, polyglyceryl-3 diisostearate, -3 polyricinoleate of polyglycereol,
PEG-10 Polydimethylsiloxane, lauryl PEG-10 tri- (trimethylsiloxy group) silica ethyl polymethyl siloxane, sorb smooth three
The mixture of the smooth oleate of stearate, sorb, sorbitan sesquioleate and the smooth trioleate of sorb, PEG-8 poly dimethyl
Siloxanes, double-isobutyl group PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymer, dimethyl silicone polymer PEG-10/15 crosslinking
Polymer, -2 sesquioleate of polyglycereol, PEG-30 dimerization hydroxy stearic acid ester, the smooth olive oleate of sorb, the poly- diformazan of PEG-9
Radical siloxane, lauryl PEG/PPG-18/18 dimethyl silicone polymer, in cetyl PEG/PPG-10/1 dimethyl silicone polymer
At least one.
4. multiple-phase emulsion according to claim 1 or 2, it is characterised in that: the oil phase thickeners are that trihydroxy is stearic
At least one of acid esters, aluminium/magnesium hydroxide tristearin acid complex, modified montmorillonoid.
5. multiple-phase emulsion according to claim 1 or 2, it is characterised in that: the grease is caprylic/capric glycerol three
At least one of ester, isopropyl myristate, saualane, triglycerides, isononyl isononanoate.
6. multiple-phase emulsion according to claim 1 or 2, it is characterised in that: the water phase thickener is poly- for polyacrylic acid
Close object, hydroxyethyl cellulose, carboxymethyl cellulose, carboxy-propyl cellulose, guar gum, xanthan gum, gelatin, hydroxypropul starch phosphorus
Acid esters, guar gum hydroxypropyl-trimethyl ammonium chloride, hectorite, aluminum magnesium silicate, soluble starch, gum arabic, alginic acid
At least one of sodium.
7. multiple-phase emulsion according to claim 1 or 2, it is characterised in that: the natural water-soluble colorants are tetrapyrrole
Derivative, isoprene derivatives, anthocyanin analog derivative, ketones derivant, naphthoquinone derivatives, at least one in caramel colorant
Kind, the tetrapyrrole derivative is at least one of chlorophyll, chlorophyll copper sodium, ferroheme, the isoprene derivatives
For at least one of capsanthin, Gardenia Yellow, beta carotene, the anthocyanin analog derivative red, rose for more Exocarpium Citri Rubrum, Grape Skin
Rare eggplant is red, radish red, beet red, at least one of red in sweet potato, semen sojae atricolor is red, mulberry fruit is red, the ketones derivant be curcumin,
At least one of monascorubin, safflower yellow, Cacao pigment, the naphthoquinone derivatives be lac is red, in alkermes extremely
Few one kind.
8. multiple-phase emulsion according to claim 1 or 2, it is characterised in that: the quality of the w/o type first phase and outer aqueous phase
Than for 30:70;
The w/o type first phase includes the cetyl PEG/PPG-10/1 dimethyl silicone polymer that mass percent is 5%, 10%
Caprylic/capric triglyceride, 10% isopropyl myristate and 0.3% modified montmorillonoid;
The outer aqueous phase include mass percent be 0.5% xanthan gum, 1% stereth -21 and 1% polysorbate60.
9. the preparation method of the described in any item multiple-phase emulsions of claim 1-8, it is characterised in that: the preparation method includes
Following steps:
(1) first by w/o type emulsifier, grease and oil phase thickeners under 3000-5000rpm homogeneous 2-4min, obtain oily phase;
(2) natural water-soluble colorants solution being slowly added drop-wise in the oily phase, the side Bian Junzhi is added dropwise, after dripping,
Homogeneous 3-7min under the conditions of 4000-6000rpm forms stable W/O emulsion, obtains w/o type first phase;
(3) under conditions of 40-50 DEG C, 200-600rpm, first water phase is uniformly mixed, then the w/o type first phase is dripped dropwise
It is added to described just in water phase, drips and be stirred for 20-30min and can be prepared by the multiple-phase emulsion.
10. the application of the described in any item multiple-phase emulsions of claim 1-8, it is characterised in that: the multiple-phase emulsion is used for
Cosmetics are prepared, the cosmetics include facial mask, essence, lotion, creme or lipstick.
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