CN116270270A - Preparation method and application of supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion - Google Patents
Preparation method and application of supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion Download PDFInfo
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- CN116270270A CN116270270A CN202310412570.0A CN202310412570A CN116270270A CN 116270270 A CN116270270 A CN 116270270A CN 202310412570 A CN202310412570 A CN 202310412570A CN 116270270 A CN116270270 A CN 116270270A
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- sun
- mosquito
- micro
- supermolecule
- repellent
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- 239000002775 capsule Substances 0.000 title claims abstract description 61
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a preparation method of supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion and application thereof, in particular to a preparation method of active efficacy substances carried out by synergic emulsification by adopting ionic liquid, which comprises the steps of uniformly dissolving ionic liquid, oil phase efficacy substances, emulsifying agent and oil ester to be used as an oil phase, uniformly dissolving water phase basic components and water phase efficacy substances to be used as a water phase, carrying out high-speed heat preservation shearing on water-oil phases to be used as colostrum, and homogenizing under high pressure to obtain the supermolecule micro-lipid capsule emulsion with sun-proof mosquito repellent effect; the supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion uses supermolecule micro-lipid capsule technology, adopts ionic liquid to carry out the entrapment of active substances, has simple entrapment capacity and long-acting slow release and dual powerful effects of mosquito repellent and sun-proof; the preparation method of the novel supermolecule emulsion with high-efficiency load and ionic liquid entrapment provided by the invention can be widely applied to the field of cosmetics.
Description
Technical Field
The invention relates to the technical field of cosmetic raw materials, in particular to a preparation method and application of supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Background
The ionic liquid as a novel modification technology has been recently developed in the cosmetic industry, has good properties, and has excellent properties in extraction of active ingredients, stability of active ingredients, modification of active substances, and the like. The ionic liquid has almost no vapor pressure in water, incombustibility and non-volatility, has good chemical stability and thermal stability in a system, has good environment and self-assembly properties according to the self-defined regulation design development of functions, and has been applied to the fields of separation, extraction, catalysis, nanomaterials, electrochemistry, cosmetics and the like.
The supermolecule microcapsule emulsion is a standard product of supermolecule microcapsule encapsulation technology, which combines ionic liquid with fat emulsion and liposome, and adopts the ionic liquid to carry out encapsulation on active functional components. Traditional liposome technology is increasingly used frequently in the cosmetic field in recent years, and phospholipid is often used for encapsulation, however, for some functional substances with strong electronegativity and high loading, phospholipid modification encapsulation still has a great challenge in skin feel and stability. Compared with the traditional encapsulation technology, the supermolecule microcapsule encapsulation technology has the advantages of larger loading capacity and higher loading efficiency. The ionic liquid has stronger charge repulsive interaction between liquid drops on the surface of the microcapsule of the ionic liquid, so that an emulsifying system is more stable, and the strength of the wrapping film can be enhanced by adding the ionic liquid, so that the loaded active content of the wrapping film is higher.
The traditional multifunctional sun-proof mosquito repellent emulsion is generally formed by compounding multiple functional substances capable of absorbing different wave bands, and when the functions are more, the more raw materials are used, the more complex the system is, and the greater the risk of system stability is. Generally, to achieve the above effects, it is required that the functional material has a particle size of 100nm to 500nm or has a good absorption at the wavelength of this interval. The traditional sun-proof emulsion generally has the particle size of tens of micrometers, and inorganic sun-proof agents are added into the system to carry out physical sun-proof, and chemical sun-proof is mainly implemented in the functional objects wrapped by micrometers. Thus, conventional sunscreens have problems such as the addition of inorganic sunscreens which reduce the stability of the whole emulsion system, the concentration of light in the emulsion of micron order is mainly reflected and scattered, the absorption efficiency of organic sunscreens to ultraviolet is relatively low, and thus the sunscreens need to be used too much to increase the sun protection index to reach a certain sun protection value, thus causing the dosage of sunscreens of the whole emulsion system to be increased, which is a challenge to emulsion stability.
Disclosure of Invention
The invention aims to provide a preparation method and application of supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion, which can wrap unstable active substances by using a supermolecule micro-lipid capsule technology and aims to solve the problems of excessive use amount of a light absorbent, large irritation of active ingredients, instability and the like. The problems of excessive use of the sun-screening agent, low efficiency and utilization rate and stability caused by the use of the inorganic sun-screening agent due to the overlarge particle size of the traditional sun-screening emulsion are solved; meanwhile, as the particle size of the emulsion is between 100nm and 500nm, the emulsion particle size can also absorb harmful wavelengths in sunlight better, and finally the addition of the ionic liquid is helpful for improving the stability of the emulsion. The method has the advantages of green and environment-friendly preparation process, simple preparation method, high efficiency and high stability, so as to realize the efficient sun-proof and mosquito-repellent effects.
The invention provides a preparation method and application of supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion, wherein the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion comprises active ingredients, ionic liquid, emulsifying agent, thickening agent, auxiliary ingredients and deionized water, and the mass components of the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion are as follows: the active component is 0.1-31%, the ionic liquid is 0.1-5.0%, the emulsifying agent is 0.4-6.0%, the thickening agent is 0.1-5%, the auxiliary component is 0.1-5.0%, and the balance is deionized water.
The active ingredients in the supermolecule microcapsule sun-proof mosquito-repellent emulsion are one or a combination of the components of the ultra-molecule microcapsule sun-proof mosquito-repellent emulsion, namely, the active ingredients of the supermolecule microcapsule sun-proof mosquito-repellent emulsion are O Li Kelin, 2-phenylbenzimidazole-5-sulfonic acid, polysiloxane-15, diethylaminohydroxybenzoyl hexyl benzoate, eucalyptus oil, citramidol, DEET, mosquito-repellent fat, elcatin, grape seed oil, ethylhexyl salicylate, homosalate, tocopheryl acetate and the like.
Wherein the ionic liquid in the supermolecule microcapsule sun-proof mosquito-repellent emulsion is one or a combination of matrine camellia oil, menthol coenzyme Q10, betaine salicylic acid, matrine prinsepia utilis royle oil and L-carnitine tartaric acid.
Wherein the emulsifier in the supermolecule microcapsule sun-proof mosquito repellent emulsion is any one of sodium stearate, sodium dodecyl sulfate, fatty acid sorbitan, polysorbate, herba Euphorbiae Helioscopiae, benzyl Euphorbiae, poloxamer, lecithin, soybean lecithin, egg yolk, cetyl alcohol, beeswax, stearic acid, stearyl alcohol, phosphatidylethanolamine, cholesterol, sodium taurocholate, beta-sitosterol and cholesterol acetyl ester, and their combination.
Wherein, the thickener in the supermolecule microcapsule sun-proof mosquito repellent emulsion is one of acacia, tragacanth, gelatin, apricot gum, ammonium acryloyldimethyl taurate/VP copolymer and the combination thereof.
Wherein, the auxiliary components in the supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion are any one of EDTA-2Na, sodium metabisulfite, vitamin C and vitamin E and the combination thereof.
The invention provides a preparation method and application of a supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion for wrapping different sun-proof and mosquito-repellent active ingredients, referring to fig. 1, fig. 1 is a flow chart of an embodiment of the preparation method of the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion for wrapping unstable active matters, and the method comprises the following steps:
(1) Preparing a micro-lipid capsule solution for the sun-proof mosquito-repellent emulsion, and placing the micro-lipid capsule solution in an inert gas atmosphere at a preset temperature of 60-80 ℃;
(2) The water phase is stirred uniformly by starting shearing, the oil phase is slowly added into the water phase under the shearing condition, the water phase is sheared for 3 to 5 minutes at high speed, and then the water phase is homogenized under high pressure or subjected to micro-jet treatment;
(3) After high-pressure homogenization or micro-jet treatment, 0.1-5.0% of thickening agent is added, wherein the thickening agent is any one of acacia, tragacanth, gelatin, apricot gum, and acrylamide/VP copolymer, and the combination thereof, and the mixture is stirred and dispersed uniformly to obtain the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Wherein, the high-pressure homogenizer is preferably a two-step high-pressure homogenizer, and the homogenization conditions are as follows: the primary valve homogenizing pressure is 400-1500bar, preferably 600-1000bar; the secondary valve is 0-200bar, preferably 50-150bar; homogenizing for 2-15 times, preferably 6-10 times; the homogenization temperature is 0-80 ℃, preferably 40-60 ℃.
Wherein the homogenization conditions of the microfluidics are a pressure of 400-1500bar, preferably 600-1000bar; homogenizing for 2-15 times, preferably 6-10 times; the homogenization temperature is 0-80 ℃, preferably 40-60 ℃.
The supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion is obtained after high pressure homogenization or micro-jet treatment.
The invention successfully prepares the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion and the preparation method and the application thereof, and solves the limitation of various active ingredients in the use of cosmetic formulas.
Compared with the prior art, the invention has the beneficial effects that: the invention adopts the supermolecule micro-lipid capsule technology to wrap, reduces the irritation caused by the active substances, and simultaneously ensures the long-acting performance of sun protection and mosquito repelling by one layer. Compared with the traditional sun-proof mosquito repellent liquid, the mosquito repellent liquid has the advantages that:
1. the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion is prepared by wrapping sun-screening agent and mosquito-repellent agent by ionic liquid, has the particle size in the nanometer range, and can maintain good refreshing experience on skin feel compared with the traditional sun-screening mosquito-repellent emulsion with the particle size of 5-50 microns;
2. the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion is added with supermolecule micro-lipid capsule technology on the basis of the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion, the particle size is in the nanometer range, and compared with the traditional sun-proof mosquito-repellent emulsion with the particle size of 5-50 microns, the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion has better ultraviolet light absorption effect. Therefore, the sun-screening effect can be obviously improved, and the higher sun-screening effect under the same sun-screening agent content is realized;
3. the mosquito repellent active ingredient is dispersed in the sun-screening active ingredient instead of the ethanol solution, so that the volatilization speed is slow, and the mosquito repellent time is long. Meanwhile, compared with the traditional mosquito-repellent formula, the mosquito-repellent formula contains volatile components such as ethanol, and the mosquito-repellent formula does not contain ethanol, so that the mosquito-repellent formula has higher safety;
4. after the mosquito repellent component volatilizes, the concentration of the sun-screening agent is increased, so that the sun-screening effect is better along with the volatilization of the mosquito repellent active component. The two components cooperate, the mosquito is effectively repelled for a long time and the sun is effectively protected.
The supermolecule micro lipid capsule is prepared by introducing the supermolecule ion liquid, and the technical operation practicability is strong.
Drawings
FIG. 1 is a flow chart of a preparation method of the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion;
FIG. 2 is a diagram of an ultra-molecular microcapsule sun-screening mosquito-repellent emulsion of the present invention;
FIG. 3 is a graph of particle size of the supermolecule microcapsule sun-screening mosquito-repellent emulsion of the present invention (after high pressure homogenization);
FIG. 4 is a potential diagram of the supermolecule micro lipid vesicle sunscreen mosquito repellent emulsion of the present invention;
FIG. 5 is a chart of a sun-screening test of the supermolecule micro lipid vesicle sun-screening mosquito repellent emulsion of the present invention;
FIG. 6 is a volatile diagram of the mosquito repellent active ingredients of the supermolecule lipid vesicle sunscreen mosquito repellent emulsion of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent.
It should be understood that the specific examples and comparative examples described herein are merely illustrative of the present invention and are not intended to limit the present invention as shown in fig. 1 to 6.
Example 1
The preparation method of the composition with the sun-proof value of the supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion of more than or equal to 15 comprises the following steps:
(1) Weighing 3 parts of O Li Kelin, 0.5 part of mosquito repellent fat, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 1 part of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring and uniformly mixing;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 75.9 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 2
The preparation method of the composition with the sun-proof value of the supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion of more than or equal to 30 comprises the following steps:
(1) Weighing 4 parts of o Li Kelin, 0.5 part of citral, 4 parts of homosalate, 4 parts of 2-phenylbenzimidazole-5-sulfonic acid, 2 parts of polysiloxane-15, 2 parts of diethylamino hydroxybenzoyl hexyl benzoate, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 1 part of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring uniformly;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 62.9 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 3
The preparation method of the composition with the sun-proof value of the supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion of 50 or more comprises the following steps:
(1) Weighing 10 parts of O Li Kelin, 10 parts of homosalate, 2 parts of 2-phenylbenzimidazole-5-sulfonic acid, 5 parts of polysiloxane-15, 5 parts of diethylamino hydroxybenzoyl hexyl benzoate, 0.5 part of eucalyptus oil, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring uniformly;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 44.9 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 4
The preparation method of the composition of the single mosquito repellent component of the supermolecule micro-lipid capsule sun-screening mosquito repellent emulsion comprises the following steps:
(1) Weighing 1 part of mosquito repellent fat, 3 parts of ao Li Kelin, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring and uniformly mixing;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 71.4 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 5
The preparation method of the composition of the single mosquito repellent component of the supermolecule micro-lipid capsule sun-screening mosquito repellent emulsion comprises the following steps:
(1) Weighing 10 parts of mosquito repellent fat, 3 parts of ao Li Kelin, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring and uniformly mixing;
(2) Weighing 0.5 part of 1, 2-pentanediol, 3 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 61.4 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 6
The preparation method of the composition of the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion with various mosquito-repellent components comprises the following steps:
(1) Weighing and mixing 0.5 part of eucalyptus oil, 1 part of citral, 1 part of DEET, 1 part of mosquito repellent fat, 0.5 part of elcatilin, 3 parts of O Li Kelin, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, heating to 75 ℃, and stirring and mixing uniformly;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 70.4 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 7
The preparation method of the composition of the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion with various mosquito-repellent components comprises the following steps:
(1) Weighing 6 parts of citral, 1 part of DEET, 1 part of mosquito repellent fat, 3 parts of O Li Kelin, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring and uniformly mixing;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 64.9 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 8
The preparation method of the composition of the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion with various mosquito-repellent components comprises the following steps:
(1) Weighing and mixing 0.5 part of eucalyptus oil, 1 part of citral, 1 part of DEET, 3 parts of O Li Kelin, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, heating to 75 ℃, and stirring and mixing uniformly;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 70.4 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Example 9
The preparation method of the composition of the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion with various mosquito-repellent components comprises the following steps:
(1) Weighing 1 part of mosquito repellent fat, 1.5 parts of elcatting, 3 parts of ao Li Kelin, 0.5 part of matrine camellia oil, 6 parts of grape seed oil, 2 parts of dioctyl carbonate, 3 parts of soybean lecithin and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring and uniformly mixing;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 71.9 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component;
(4) And (3) carrying out high-pressure homogenization treatment on the sheared material body in the step (3), then adding 0.2% apricot gum, and stirring and dispersing uniformly to obtain the finished supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
Comparative example 1
The preparation method of the common sun-proof emulsion with the sun-proof value of more than or equal to 15 comprises the following steps:
(1) Weighing 3 parts of O Li Kelin, 6 parts of grape seed oil, 3 parts of dioctyl carbonate, 2 parts of stearic acid and 0.5 part of tocopheryl acetate, mixing, heating to 75 ℃, and stirring and mixing uniformly;
(2) Weighing 0.5 part of 1, 2-pentanediol, 2 parts of glycerol, 6 parts of butanediol, 0.1 part of EDTA disodium, 2 parts of hexanediol and 74.9 parts of water, mixing, heating to 75 ℃, and uniformly stirring;
(3) Slowly adding the oil phase in the step (1) into the water phase in the step (2) under the shearing condition, and continuously shearing for 4 minutes to fully and uniformly mix the oil phase component and the water phase component; obtain the common sun-proof mosquito-repellent emulsion.
Compared with the prior art, the invention has the beneficial effects that: the invention adopts the supermolecule micro-lipid capsule technology to wrap, reduces the irritation caused by the active substances, and simultaneously ensures the long-acting performance of sun protection and mosquito repelling by one layer. Compared with the traditional sun-proof mosquito repellent liquid, the mosquito repellent liquid has the advantages that:
1. the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion is prepared by wrapping sun-screening agent and mosquito-repellent agent by ionic liquid, has the particle size in the nanometer range, and can maintain good refreshing experience on skin feel compared with the traditional sun-screening mosquito-repellent emulsion with the particle size of 5-50 microns;
2. the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion is added with supermolecule micro-lipid capsule technology on the basis of the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion, the particle size is in the nanometer range, and compared with the traditional sun-proof mosquito-repellent emulsion with the particle size of 5-50 microns, the supermolecule micro-lipid capsule sun-proof mosquito-repellent emulsion has better ultraviolet light absorption effect. Therefore, the sun-screening effect can be obviously improved, and the higher sun-screening effect under the same sun-screening agent content is realized;
3. the mosquito repellent active ingredient is dispersed in the sun-screening active ingredient instead of the ethanol solution, so that the volatilization speed is slow, and the mosquito repellent time is long. Meanwhile, compared with the traditional mosquito-repellent formula, the mosquito-repellent formula contains volatile components such as ethanol, and the mosquito-repellent formula does not contain ethanol, so that the mosquito-repellent formula has higher safety;
4. after the mosquito repellent component volatilizes, the concentration of the sun-screening agent is increased, so that the sun-screening effect is better along with the volatilization of the mosquito repellent active component. The two components cooperate, the mosquito is effectively repelled for a long time and the sun is effectively protected. The supermolecule microcapsule is prepared by introducing the supermolecule ion liquid, and has strong technical practicability.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art will understand that; the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced with equivalents; such modifications and substitutions do not depart from the spirit of the invention, and are intended to be included within the scope of the appended claims and description.
Claims (10)
1. The supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion is characterized by comprising active ingredients, ionic liquid, an emulsifying agent, a thickening agent, auxiliary ingredients and deionized water, wherein the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion comprises the following components in parts by mass: the active component is 0.1-31%, the ionic liquid is 0.1-5.0%, the emulsifying agent is 0.4-6.0%, the thickening agent is 0.1-5%, the auxiliary component is 0.1-5.0%, and the balance is deionized water.
2. The supermolecule microcapsule sun protection and mosquito repellent emulsion of claim 1, wherein the active ingredient is any one of o Li Kelin, 2-phenylbenzimidazole-5-sulfonic acid, polysiloxane-15, hexyl diethylaminobenzoate, eucalyptus oil, citramidol, DEET, mosquito repellent fat, elcatin, grapeseed oil, ethylhexyl salicylate, homosalate, tocopheryl acetate, and combinations thereof.
3. The supramolecular lipid vesicle sun-screening and mosquito-repellent emulsion of claim 1, wherein the ionic liquid is any one of matrine camellia oil, menthol coenzyme Q10, matrine prinsepia utilis royle oil and combinations thereof.
4. The supramolecular microcapsule sun-protection mosquito-repellent emulsion of claim 1, wherein the emulsifier is any one of sodium stearate, sodium lauryl sulfate, sorbitan fatty acid, polysorbate, selejol, benzyl jol, poloxamer, lecithin, soy lecithin, egg yolk, cetyl alcohol, beeswax, stearic acid, stearyl alcohol, phosphatidylethanolamine, cholesterol, sodium taurocholate, β -sitosterol, and cholesterol acetyl ester, and combinations thereof.
5. The supramolecular microcapsule sun protection mosquito repellent emulsion of claim 1, wherein the thickener is any one of acacia, tragacanth, gelatin, apricot gum, ammonium acryloyldimethyl taurate/VP copolymer and combinations thereof.
6. The supermolecule micro-lipid capsule sun-protection and mosquito-repellent emulsion according to claim 1, wherein the auxiliary component is any one of EDTA-2Na, sodium metabisulfite, vitamin C, vitamin E and combinations thereof.
7. The preparation method of the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion is characterized by comprising the following steps:
(1) Preparing a micro-lipid capsule solution for the sun-proof mosquito-repellent emulsion, and stirring and dissolving the oil phase in the formula amount completely in an inert gas atmosphere at a preset temperature of 60-80 ℃;
(2) The water phase is stirred uniformly by starting shearing, the oil phase is slowly added into the water phase under the shearing condition, the water phase is sheared for 3 to 5 minutes at high speed, and then the water phase is homogenized under high pressure or subjected to micro-jet treatment;
(3) After high-pressure homogenization or micro-jet treatment, 0.1-5.0% of thickening agent is added, wherein the thickening agent is any one of acacia, tragacanth, gelatin, apricot gum, and acrylamide/VP copolymer, and the combination thereof, and the mixture is stirred and dispersed uniformly to obtain the supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion.
8. The method for preparing the supermolecule micro-lipid capsule sun-proof mosquito repellent emulsion according to claim 7, wherein the high-pressure homogenizing machine is a two-step high-pressure homogenizing machine, and the homogenizing conditions are as follows: the homogenizing pressure of the first-stage valve is 500-1600bar; the secondary valve is 0-200bar; homogenizing for 4-16 times; the homogenization temperature is 0-85 ℃.
9. The method for preparing the supermolecule micro-lipid capsule sun-protection mosquito-repellent emulsion according to claim 7, wherein the homogenizing condition of the micro-jet is pressure of 500-1600bar; homogenizing for 4-16 times; the homogenization temperature is 0-85 ℃.
10. The supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion is characterized by having high-efficiency sun-screening and mosquito-repellent capabilities, having remarkable synergistic effect, being better applied to the field of cosmetics, enabling active substances to be more stable and remarkably improving sun-screening and mosquito-repellent effects.
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|---|---|---|---|
| CN202310412570.0A CN116270270A (en) | 2023-04-18 | 2023-04-18 | Preparation method and application of supermolecule micro-lipid capsule sun-screening mosquito-repellent emulsion |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116850084A (en) * | 2023-07-11 | 2023-10-10 | 深圳杉海创新技术有限公司 | Surface-coated hydroxy pinacolin retinoic acid ester, preparation method, application and composition containing hydroxy pinacolin retinoic acid ester |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116850084A (en) * | 2023-07-11 | 2023-10-10 | 深圳杉海创新技术有限公司 | Surface-coated hydroxy pinacolin retinoic acid ester, preparation method, application and composition containing hydroxy pinacolin retinoic acid ester |
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