KR101363757B1 - Double layered capsule for cosmetics and method of manufacturing the same - Google Patents

Abstract

The present invention relates to a double capsule for cosmetics and a method for manufacturing the same, the present invention can maintain a high stability by blocking the inflow of oxygen to vitamins in the center, and excellent formulation stability can be used as a base material in any form of cosmetics To provide a cosmetic double capsule possible and a method for producing the same.

Description

Double layered capsule for cosmetics and method of manufacturing the same

The present invention relates to a cosmetic double capsule and a method for manufacturing the same, and more particularly, a cosmetic double capsule containing a vitamins and the like in the inner center of the center and excellent in storage stability, to provide a thermodynamically stable cosmetic and It relates to a manufacturing method.

Vitamins are a lot of efforts in the thermodynamic stabilization because they have a lot of functions and efficacy in the cosmetic field, but the situation is not secured the completed technology.

Among the vitamins, retinol and its derivatives, particularly vitamin A, are representative active ingredients that have the effect of improving skin wrinkles, but when mixed with cosmetic formulations, they are very labile or thermodynamically unstable. These are complaining difficulties.

In addition, vitamin B6 and its derivatives are also effective in promoting the production of filagrin, which is a very unstable component that is easily oxidized when exposed to air as a component having a good function for moisturizing effect of skin. Vitamin C and its derivatives are known to have the function of bleaching melanin pigment in the skin or inhibiting melanin production, and it is widely known as an ingredient that helps the skin whitening effect that makes skin clear and transparent. When accompanied with (-OH) radicals, it is easily oxidized and its potency decreases, and it is a component having a lot of difficulty for use in cosmetics that need to be used for a long time.

Vitamin E (tocopherol) and its derivatives also have excellent skin antioxidant effects, but their long-term preservation is not very good.

Thus vitamins can be used as an external skin preparation for each efficacy cosmetics, there is a side that can not be effective due to the above disadvantages. Efforts have been made to double encapsulation for stabilization of vitamins, and Korean Patent No. 10-0173445 discloses a fat-soluble active substance that is easily oxidized in aqueous solution or air, retinoids, tocopherols, unsaturated fatty acids or derivatives thereof, fat-soluble pigments or The present invention relates to a cosmetic double capsule prepared in a size of 0.01 to 2 mm by encapsulating the first matrix microcapsules encapsulated with vitamin F as gellan gum, and a composition comprising the same.

Republic of Korea Patent No. 10-0544443 relates to a method for producing a 0.5 to 20 size chitosan microcapsules containing fat-soluble vitamins, vitamin derivatives or fat-soluble active ingredients. The present invention relates to an anionic surfactant, a coacervation-enhancing component chitosan in water-in-oil (W1 / O / W2) type multi-emulsion method and chitosan microcapsules.

Republic of Korea Patent No. 10-0267356 relates to a stabilized cosmetic composition containing a retinyl palmitate capsule. The present invention is a cosmetic containing microcapsules with retinyl palmitate as an inner phase, containing tocopherol as an antioxidant, wrapped with collagen and glycosaminoglycan crosslinked coating agent, microencapsulated, suspended on a water-soluble gel and then tocopherol acetate The present invention relates to an o / w cosmetic containing dibutyl hydroxytoluene and an antioxidant.

Korean Patent No. 10-1032623 relates to a double capsule and a composition containing the same, characterized in that the capsules made of methacrylate copolymers having the property of being opened by hydrogen ion action are encapsulated in capsules based on phospholipids. .

Republic of Korea Patent No. 10-0810164 is an anti-wrinkle cosmetic composition containing idebenone nanocapsules, including a core portion, the inner capsule portion, the outer capsule portion.

Common methods of primary encapsulation include emulsion dispersion method, liposome method, and oil-in-water multi-emulsification method.However, the formulations have a low point in which hydroxyl groups (-OH) and oxygen (O2) are easily present in water. There is a lot of problems to maintain the high stability because it is easy to move the material or oxygen inflow in the liquid or cream state of the island.

The polymers used for the second encapsulation are collagen, hyaluronic acid, gellan gum, agar, etc., but these are technologies that use the characteristics of curing depending on the temperature. Although the components have, it can vary greatly depending on the composition and manufacturing method of each component.

The present invention is to provide a cosmetic double capsule and a method for manufacturing the same that can maintain a high stability by blocking the inflow of oxygen to vitamins in the center.

The present invention is to provide a double capsule for cosmetics and a method of manufacturing the same, easy to use without foreign body because the first capsule is absorbed into the skin while the capsule membrane is gently broken when rubbed on the skin.

The present invention is to provide a double capsule for cosmetics and a method for producing the same that can be used as a base material in any form of cosmetics with excellent formulation stability.

The present invention seeks to provide cosmetics whose efficacy lasts for a long time.

The present invention provides a preferred first embodiment is a primary capsule formed of semi-solid or solid phospholipid nanoparticles; And it is formed on the outside of the primary capsule, and provides a cosmetic double capsule comprising a secondary capsule containing a matrix polymer.

In this embodiment, the primary capsule is 5-20 wt% of vegetable higher fatty alcohol or higher fatty acid, 0.1-10 wt% of hydrogenated lecithin, 0.01-5 wt% of soysterol, 0.1-10 wt% of nonionic or anionic surfactant, 30 wt% of glycerin Or less, the polyol 20wt% or less and the rest may include purified water so that the total content is 100wt%.

In the above embodiment, the primary capsule may further comprise 1 ~ 30wt% of nonpolar or polar oil.

In the above embodiment, the secondary capsule may include 0.1 to 10 wt% of gamma cyclodextrin, 0.01 to 5 wt% of coagulant, 0.01 to 5 wt% of alginate polymer, and 100 wt% of the rest so that the total content is 100 wt%.

In the above embodiment, the dual capsule for cosmetic may have a particle diameter of 0.1mm ~ 1cm.

In the above embodiment, the primary capsule may be a vitamin is sealed therein.

In the above embodiment, the vitamins may be one or two or more selected from vitamins A to H, K and derivatives thereof.

As a second preferred embodiment, the secondary capsule material comprising 0.1 to 10 wt% of gamma cyclodextrin, 0.01 to 5 wt% of coagulant and 0.01 to 5 wt% of alginate polymer is dissolved and cooled at 50 to 70 ° C. in purified water. step; Mixing with a primary capsule formed of semisolid or solid phospholipid nanoparticles; And it provides a method for producing a double capsule for cosmetic comprising a step of encapsulating through a nozzle.

In the above embodiment, the primary capsule is 5 to 20 wt% of vegetable higher fatty alcohol or higher fatty acids, 0.1 to 10 wt% of hydrogenated lecithin, 0.01 to 5 wt% of soysterol, 0.1 to 10 wt% of nonionic or anionic surfactant, 80 to 100 Dissolving at ° C .; Mixing the remaining components with 30 wt% or less of glycerin, 20 wt% or less of polyol, and purified water and cooling the mixture to 40 to 60; Putting the components for encapsulation into the cooled components and stirring for 3 to 10 minutes at 2,000 to 4,000 rpm; Injecting the stirred component into a microfluidizer may include a step of talking 1 to 5 times at 1,000 ~ 20,000psi pressure.

The present invention provides a cosmetic comprising a double capsule for cosmetics of the first embodiment as a third preferred embodiment.

In the above embodiment, the cosmetic double capsule may be included in an amount of 0.01 to 50wt% based on the total weight of the cosmetic composition.

According to the present invention, by blocking the inflow of oxygen to vitamins in the center to prevent the progress of oxidation and rancidity, stable to heat and light, and maintains the potency of the ingredients to provide a cosmetic double capsule for maintaining the stability and its manufacturing method can do.

In addition, when rubbed into the skin, the capsule membrane is softly broken and the primary capsule can be absorbed into the skin to exert its efficacy, thereby providing a double capsule for cosmetics and a method of manufacturing the same, which is easy to use without foreign substances.

According to the present invention, it is possible to provide a cosmetic double capsule and a method for manufacturing the same, which can be used as a base material with excellent cosmetic stability.

In addition, it is easy to absorb skin, and its effect can be doubled in small amount, and it can be applied to products with various skin improvement effects such as fine wrinkle improvement, whitening, anti-inflammatory, acne improvement, atopy, psoriasis skin improvement, etc. It is possible to provide a capsule and a method of manufacturing the same.

In addition, it can provide a cosmetic double capsule and cosmetic manufacturing method that can be seen in a high-quality appearance because it is visible in the form of particles, such as cosmetics, cosmetic essence, cream.

1 is a view schematically showing a cosmetic double capsule of the present invention,
2 is a product picture of the cosmetic double capsule of the present invention,
3 is an electron micrograph of the phospholipid nanoparticles in the cosmetic double capsule of the present invention,
4 is a graph showing the long-term stability of Example 5 and Comparative Example 2,
5 is a graph showing the long-term stability of Examples 11-14 and Comparative Example 4.

Hereinafter, the present invention will be described in more detail.

The present invention provides a preferred first embodiment is a primary capsule formed of semi-solid or solid phospholipid nanoparticles; And it is formed on the outside of the primary capsule, and provides a cosmetic double capsule comprising a secondary capsule containing a matrix polymer.

1 schematically illustrates a double capsule of the present invention, in which a secondary matrix capsule is formed on the surface of a primary semi-solid or solid phospholipid nanoparticle complex.

Each of the primary capsule and the secondary capsule will be described in detail.

(1) Preparation of semisolid or solid phospholipid nanoparticles

The manufacturing method for the primary capsule is 5-20 wt% of vegetable higher fatty alcohol or higher fatty acids, 0.1-10 wt% of hydrogenated lecithin, 0.01-5 wt% of soysterol, 0.1-10 wt% of nonionic or anionic surfactant, and 30 wt% of glycerin or less. , Purified water is used so that the polyol is less than 20wt% and the total content is 100wt%, and according to the characteristics of the active ingredient, the non-polar or polar oils are less than 1wt% and more than 30wt% to boil them in a heated bath. You can make a car base.

As the vegetable higher fatty alcohol or higher fatty acid, one or two or more selected from fatty acids of C12-C30 may be used for fatty acid residues such as lauryl, myristyl, palmityl, cetyl, stearyl, and behenyl. These fatty acids are characterized by being easily cured by being mixed with fatty alcohols, and form a primary structure having the best chain length of about 12 to 30 carbon atoms. In particular, more stable structures are formed when suitable surfactants are incorporated.

The hydrogenated lecithin has a good oxidation stability compared to the lecithin containing unsaturated fatty acids, it is also widely used as a cosmetic raw material that requires long-term stability due to the decoloring, deodorizing effect. In addition, since it has a structure similar to the lipid component of the skin, it has high skin affinity, thereby improving skin absorption. In consideration of this point it is better to mix 0.1 ~ 10wt%.

The soy sterols may act to stably reinforce the primary capsule membrane, and may be mixed in a range of 0.01 to 5 wt% in consideration of the solidification hardness of the primary capsule and the stability of the capsule.

The nonionic or anionic surfactants can be easily dispersed when the components of the primary capsules are dispersed in water or diluted in other solvents, and the mixtures of fatty acid or fatty alcohol mixtures with aqueous solutions Will. In consideration of the irritability of the surfactant and the suitability of the formulation, 0.1 to 10wt% is used.

On the other hand, glycerin is intended to soften so as to control the hardness of the primary solid particles, that is, to have an appropriate hardness that is soft and not hard, and may be used in an amount of 30wt% or less in consideration of the usefulness of the skin and viscosity control of the invention.

The polyols may be used to assist in stabilizing the auxiliary surfactant and the primary capsule, and may be used in an amount of 20 wt% or less in consideration of appropriate hardness control.

Here, purified water is used to make a formulation having a semi-solid hardness suitable for the overall composition, and the remaining total content may be mixed to 100 wt%.

The primary solid phospholipid base mixed as described above is mixed with an active ingredient vitamin alone or two or more types and encapsulated in solid particles, and nanoparticles are passed through a high pressure homomixer microfluidizer for nanoparticles. At this time, since the hardness of the solid particles vary depending on the composition of the solid phospholipid, it must be passed through a microfluidizer by controlling the temperature.

Looking in more detail, the primary solid phospholipid base is dissolved, first of the vegetable higher fatty alcohol or higher fatty acid, hydrogenated lecithin, soysterol, nonionic or anionic surfactant at 80 ~ 100 ℃, and then glycerin, The remaining primary capsule material containing polyols and purified water is mixed and cooled to 40-60. Since oil-soluble and water-soluble substances do not mix well and do not dissolve, mixing the water-soluble substance first by dissolving the oil-soluble substance and mixing the water-soluble substance can be quickly and accurately manufactured.The concentration of oily phase depends on the degree of completion of the solid or semi-solid primary capsule. It can be affected, so the components can be divided and treated as above.

Put the components for the encapsulation, such as vitamins in the cooled components and stirred for 3 to 10 minutes at 2,000 ~ 4,000rpm. Through this process, vitamins may be encapsulated in the primary capsule. At this time, vitamins can be mixed about 300,000 IU per gram, and the process of encapsulating vitamins in the primary capsule is a non-uniform and large particles are produced as uniform nanoparticles through the microfluidizer. . When passing through a microfluidizer, cooling water of less than 10 can be used to prevent the titer of vitamins from dropping. In particular, in order to increase the stability, BHT (Dibutylhydroxy toluene), tocopherol and derivatives thereof, stabilizers such as EDTA, NaCl, pigments, flavorings may be added.

The stirred component is passed through a microfluidizer, which is a high pressure homo mixer, to prepare nanoparticles. At this time, the condition is to pass at least once, as many as five times at a pressure of 1,000 ~ 20,000 psi, more than that possible, but in order to increase the production efficiency in the present invention, it is recommended to pass three times, but the type of vitamin Therefore, it is not necessarily limited to this. The material thus obtained is made of solid or semisolid phospholipid nanoparticles.

As such, by enclosing vitamins or the like into semi-solid or solid phospholipid nanoparticles, the free brown motion of the vitamins can be controlled, so there is an advantage that they are not released or mixed. In addition, since they form thermodynamically stable nanostructures, they are less likely to be exposed to air.

(2) Preparation of Matrix Encapsulation

In general, the most commonly used method is to use liposomes, which form a very thin monomolecule or two or more molecules, and the encapsulated material is diffused and released out depending on the temperature, pH, and polarity of the material. Or, because other ingredients from outside can get inside, it is not a very efficient method for stability of soft capsules.

On the other hand, the present invention can provide a visible secondary matrix capsule of 0.1mm to 1cm by properly mixing a coagulant such as gamma cyclodextrin and carrageenan, alginic acid polymer, thereby preventing the release from the outside In addition, the protective film may be formed to prevent the inflow of oxygen from the outside. The size of the secondary capsule can be manufactured in various sizes of more than 1cm, but it is revealed that up to 1cm is presented in consideration of aesthetics and reality.

Looking at the manufacturing method in detail, the gamma cyclodextrin 0.1 ~ 10wt%, coagulant 0.01 ~ 5wt%, alginate polymer 0.01 ~ 5wt% and the total content is 100wt% to prepare a material containing the purified water. Dissolved and cooled the material containing 0.1-10 wt% of gamma cyclodextrin, 0.01-5 wt% of coagulant, and 0.01-5 wt% of alginate polymer at 50-70 ° C. to make an aqueous solution. The obtained aqueous solution is 50 wt% or less and mixed with the primary capsule, and this is dispersed through a nozzle of 0.1 ~ 10mm to make a capsule of the desired size. At this time, when the particles are dropped into the aqueous solution of calcium chloride and ethanol prepared separately, a secondary matrix beet capsule is formed.

Cosmetic double capsules of the present invention is a solid or semi-solid nanoparticles, and since the pure retinol enclosed therein is not released out of the thermodynamically stable feature can be said. In the case of general emulsions, it is an environment where water or oxygen in the air can be easily contacted, and even in the case of liposomes, since the inside of the monomolecular membrane is very soft, it is easily distorted or a substance released inside the capsule when subjected to a strong shear. They are easily acidified by contact with water and oxygen, and have the disadvantages of thermodynamic instability. On the other hand, the present invention has the advantage that the primary capsule is not only semi-solid or solid particles, but also bead encapsulated therein to prevent contact with air, as well as to secure high temperature stability.

Thus prepared double capsules may have a particle diameter of 0.1mm ~ 1cm, it can be seen as a high-quality appearance in the form of visible particles.

3 shows a photo of manufacturing the double capsule for cosmetics of the present invention described above.

When rubbed into the skin, the capsule membrane is softly broken and the primary solid or semi-solid phospholipid nanoparticles containing retinol are absorbed into the skin and the effect can be exerted.

The double capsules for cosmetics of the present invention as described above can block the air from the outside by forming a film on the surface of the primary nanoparticles and increase the stability of vitamins. In order to increase the metal ion blocker, antioxidants, stabilizers, dispersants, auxiliary surfactants, pigments, fragrances and the like can be made more stable cosmetics.

The double capsule for cosmetics developed by the present invention has excellent formulation stability and can be used as a base for all cosmetics, but for the quality of the formulation, a gelled, transparent viscous formulation, water-in-oil (W / O) type with a slight viscosity Or it can disperse | distribute to oil-in-water cosmetics of oil-in-water (O / W) type, and can use.

In addition, in the present invention, when the cosmetic double capsule is formulated in various cosmetics, depending on the characteristics of the product, it may be used in an amount of 0.01 to 50wt% based on the total weight of the cosmetic composition.

Hereinafter, the configuration of the present invention in more detail through examples, but the scope of the present invention is not limited to the following examples.

[ Example  1 to 3, Comparative Example  One]

The raw materials 1 to 8 of Table 1 were weighed and dissolved in a beaker by heating to 80 to 100 ° C., and then mixed with raw materials 9 to 11, and then cooled to 40 to 60 and stored separately. Add raw material 13, stir for 5 minutes at 2,000 ~ 4,000rpm with a homomixer, pass through a microfluidizer three times, cool down to 30, and pure retinol of primary solid or semisolid phospholipid nanoparticles 300,000 IU / Primary nanoparticles with purity g were prepared. Comparative Example 1 was prepared by stirring after stirring at 3,500 rpm for 5 minutes with a simple homomixer without passing through a microfluidizer.

           Raw material name Example 1 Example 2 Example 3 Comparative Example 1 1. Cetyl Palmitate
2. Cetyl Stearate
3. Hydrogenated Lecithin
4. Soy Sterols
5. Vegetable Squalane
6. Cetylphosphate
7. 5-30 moles of sebum bean sterol
8. Polyglycerol-10 Myristate 8.00
4.00
1.00
0.10
5.00
1.00
2.00
3.00 10.00
2.00
3.00
1.00
5.00
1.00
2.00
3.00 4.00
3.00
5.00
5.0
5.00
1.00
2.00
3.00 8.00
4.00
-
-
5.00
-
-
3.00 9. Glycerine
10. 1,3-Butylene glycol
11. Preservative
12. Purified water 3.00
5.00
Suitable amount
to 100 7.00
5.00
Suitable amount
to 100 10.00
10.00
Suitable amount
to 100 3.00
5.00
Suitable amount
to 100 13. Pure Vitamin A (Pure Retinol) 10.00 10.00 10.00 10.00  sub Total 100.00 100.00 100.00 100.00 MF Microfluidizer
(Micro-fluidizer) MF
3 passes MF
3 passes MF
3 passes -

As a result of observing the semi-solid phospholipid nanoparticles prepared by the composition of Example 1 with a scanning electron microscope (Scanning Electronic Microscopy) SEM it can be seen that the spherical nanoparticles were formed as shown in FIG. In the measurement method, the sample was lyophilized, and then the sample was cut and three-dimensionally observed. The spherical particle size was 150nm ~ 500nm, indicating that very fine semi-solid nanoparticles were formed.

[ Example  4 to 6, Comparative Example  2]

The raw materials 1 to 8 shown in Table 2 were weighed in a beaker, and then heated and dissolved in 50 to 70 ° C, followed by cooling. Raw materials 9-10 were each put and mixed, and it passed through the nozzle, the film was formed on the surface of the small grain of 0.2-5 mm, and the secondary matrix capsule was produced. Comparative Example 2 was prepared as it is.

           Raw material name Example 4 Example 5 Example 6 Comparative Example 2 Gamma cyclodextrin
2. Carrageenan
3. Sodium Alginate Polymer
4. Red No. 1
5. Yellow No. 4
6. Blue No. 1
7. Preservative
8. Purified water 3.00
1.00
0.50
Suitable amount
-
-
Suitable amount
to 100 3.00
1.00
0.50
-
Suitable amount
-
Suitable amount
to 100 3.00
1.00
0.50
-
Suitable amount
Suitable amount
Suitable amount
to 100 3.00
-
-
-
Suitable amount
-
Suitable amount
to 100 9. Example 2
10. Vitamin A (Untreated) 5.00
- 10.00
- 20.00
- -
10.00 sub Total 100.00 100.00 100.00 100.00 Remarks Red Bead Capsule Yellow Bead Capsule Green Bead Capsule -

Table 3 shows the results of measuring stability of Example 5 and Comparative Example 2.

Determination of the content of vitamin A component over a period of time under the conditions of room temperature, cold (4), constant temperature (45), acceleration (heat bath with a UV lamp at 45) for the double capsule of Example 5 and Comparative Example 2 The second capsule of Example 5 contained more than 94% of vitamin A components after one month in all conditions, but in Comparative Example 2, the second capsule showed a tendency to decrease significantly. In particular, the temperature of retinol tends to decrease under constant temperature and accelerated test conditions, indicating that it is easy to be dissipated by temperature and light.

Room temperature Cold and hot Constant temperature Acceleration Early After 1 month Early After 1 month Early After 1 month Early After 1 month % Stability of Example 5 99.5 97.8 99.5 99.2 99.1 95.8 99.4 94.7 Stability of Comparative Example 2 (%) 91.2 74.9 92.1 63.2 93.5 48.3 92.3 32.6

The result of having performed the high temperature stability test with the sample of Example 5 and the comparative example 2 is shown in FIG. Retinol stability test conditions are the result of quantitative analysis by HPLC of a sample placed in a 45-temperature bath for 12 weeks. As shown in FIG. 4, the result of testing for 12 weeks at the initial concentration of 100% showed that 95% or more remained after 12 weeks in Example 5 of the present invention. On the other hand, in the case of Comparative Example 2 which is a general mixture, it can be seen that the residual ratio of retinol after 12 weeks is reduced to about 39%.

[ Example  7-10, Comparative Example  3]

The raw materials 1 to 7 in Table 4 were added to a beaker, heated to 80 to 90, dissolved, and then mixed with raw materials 8 to 11, and then cooled to 40 to 60 and stored separately. For each example, the raw materials 12-19 were mixed with one or two or more kinds of materials, stirred at 2,000-4,000 rpm for 5 minutes with a homomixer, and then passed through a microfluidizer three times, followed by cooling and degassing to 30 to 1 Primary semi-solid or solid phospholipid nanoparticles were prepared. Comparative Example 3 was stirred for 5 minutes at 3,500 rpm with a simple homomixer without passing through a microfluidizer to complete the manufacture.

           Raw material name Example 7 Example 8 Example 9 Example 10 Comparative Example 3 1. Cetyl Palmitate
2. Cetyl Stearate
3. Hydrogenated Lecithin
4. Soy Sterols
5. Vegetable Squalane
6. Cetylphosphate
7. Polyglycerol-10 Myristate 8.00
4.00
1.00
0.10
5.00
1.00
3.00 8.00
4.00
1.00
0.10
5.00
1.00
3.00 8.00
4.00
1.00
0.10
5.00
1.00
3.00 8.00
4.00
1.00
0.10
5.00
1.00
3.00 8.00
4.00
-
-
5.00
1.00
3.00 8. Glycerin
9. 1,3-butylene glycol
10. Preservatives
11. Purified water 3.00
5.00
Suitable amount
to 100 7.00
5.00
Suitable amount
to 100 7.00
5.00
Suitable amount
to 100 10.00
10.00
Suitable amount
to 100 3.00
5.00
Suitable amount
to 100 12. Vitamin B6 and Derivatives
13. Vitamin C and Derivatives
14. Vitamin D and Derivatives
15. Vitamin E and Derivatives
16. Vitamin F and Derivatives
17. Vitamin G and Derivatives
18. Vitamin H and Derivatives
19. Vitamin K and Derivatives 10.00
-
-
-
-
-
-
- -
5.00
5.00
-

-
-
- -
-
-
5.00
5.00
-
-
- -
-
-
-
-
5.00
5.00
5.00 -
10.00
-
-
-
-
-
-            sub Total 100.00 100.00 100.00 100.00 100.00 MF Microfluidizer (Micro-
fluidizer) means high pressure mixer MF
3 passes MF
3 passes MF
3 passes MF
3 passes -

[ Example  11-14, Comparative Example  4]

The raw materials 1 to 8 shown in Table 5 were weighed in a beaker, and heated and dissolved in 50 to 70 ° C, followed by cooling. Raw materials 9-13 were added and mixed, and then passed through a nozzle to coat a small particle film of 0.2-5 mm to prepare a secondary matrix capsule. Comparative Example 4 was mixed as it is.

           Raw material name Example 11 Example 12 Example 13 Example 14 Comparative Example 4 Gamma cyclodextrin
2. Carrageenan
3. Sodium Alginate Polymer
4. Red No. 1
5. Yellow No. 4
6. Blue No. 1
7. Preservative
8. Purified water 3.00
1.00
0.50
-
-
-
Suitable amount
to 100 3.00
1.00
0.50
-
Suitable amount
-
Suitable amount
to 100 3.00
1.00
0.50
Suitable amount
-
-
Suitable amount
to 100 3.00
1.00
0.50
-
Suitable amount
Suitable amount
Suitable amount
to 100 3.0
-
-
-
Suitable amount
-
Suitable amount
to 100 9. Example 7
10. Example 8
11.Example 9
12. Example 10
13. Vitamin C (untreated) 20.00
-
-
-
- -
20.00
-
-
= -
-
20.00
-
- -
-
-
20.00
- -
-
-
-
10.00  sub Total 100.00 100.00 100.00 100.00 White beads
capsule Yellow bead
capsule Red beads
capsule Green bead
capsule

The results of the high temperature stability test with the samples of vitamin B6 of Example 11, vitamin C of Example 12, vitamin D of Example 13, and vitamin E of Comparative Example 4 of Example 14 are shown in FIG. The stability test condition of various vitamins is the result of quantitative analysis of high performance chromatography (HPLC) of a sample placed in a 45-temperature bath for 12 weeks. As shown in FIG. 5, the result of the test for 12 weeks with the concentration of the initial stage of manufacture as 100% is shown. As shown in FIG. 5, four vitamins of the invention prepared from the secondary matrix bead capsules were found to remain at least 90% after 12 weeks. On the other hand, in the case of Comparative Example 4 which is a general mixture, the residual ratio of vitamin C after 12 weeks can be seen that the stability is unstable to about 42%. In particular, in the case of vitamin C, which is the most unstable in stability, the water-soluble phosphorus was able to be encapsulated in semi-solid phospholipid nanoparticles, and the stability is also very stable, which is a unique phenomenon. do.

[ Example 15 Basic Cosmetic Beauty Essence

Using Example 5 and Example 8, the cosmetic of the essence for the basic cosmetic was prepared as follows. In Table 6 below, kana and me were weighed and sufficiently stirred at room temperature with an azimixer stirrer to disperse well. At this time, make sure that the polymers are well dispersed. Next, after preparing everything else beforehand, it mixes and completes manufacture.

As shown in Table 6, 5 wt%, 10 wt%, 20 wt% of the secondary matrix bead capsule of Example 5 was used as a component for making the cosmetic essence, and Example 8 contained 3 wt%, 5 wt%, 10 wt%. Essence was prepared. Not all parts of the present invention can be described, but three representative compositions have been presented, and the present invention is not necessarily limited thereto.

division Chemical Name Composition 1
(wt%) Composition 2
(wt%) Composition 3
(wt%) end glycerin
Butylene glycol
Dipropylene glycol
Betaine
Sodium hyaruronate
Collagen
Preservative
Purified water 2
3
3
0.2
0.2
0.1
Suitable amount
Suitable amount 2
3
3
0.5
0.2
0.1
Suitable amount
Suitable amount 2
3
3
One
0.2
0.1
Suitable amount
Suitable amount I Carbomer
Xanthan gum 0.15
0.3 0.15
0.5 0.15
0.8 All Example 5
Example 8 5
3 10
5 20
10 sub Total 100 100 100

Claims (11)

Primary capsules formed of semisolid or solid phospholipid nanoparticles; And
It is formed on the outside of the primary capsule, comprising a secondary capsule containing a matrix polymer,
The primary capsule is a vegetable higher fatty alcohol or higher fatty acid 5 ~ 20wt%, hydrogenated lecithin 0.1 ~ 10wt%, soysterol 0.01 ~ 5wt%, nonionic or anionic surfactant 0.1 ~ 10wt%, glycerin 30wt% or less, polyols Less than 20wt% and a total content of 100wt% so that the remainder is a cosmetic double capsule prepared by including purified water. delete The method of claim 1,
Primary capsule is a double capsule for cosmetics further comprises 1 ~ 30wt% of non-polar or polar oil. The method of claim 1,
Secondary capsule is gamma cyclodextrin 0.1 ~ 10wt%, coagulant 0.01 ~ 5wt%, alginate polymer 0.01 ~ 5wt% and the total content is 100wt% so that the remainder is a cosmetic double capsule prepared by including purified water. The method of claim 1,
Cosmetic double capsule with a particle size of 0.1mm ~ 1cm. The method of claim 1,
Primary capsule is a double capsule for cosmetics with vitamins inside. The method according to claim 6,
Vitamins are vitamin A ~ H, K and derivatives selected from the group consisting of two or more cosmetic double capsules. Dispersing and cooling the secondary capsule material containing 0.1 to 10 wt% of gamma cyclodextrin, 0.01 to 5 wt% of coagulant, and 0.01 to 5 wt% of alginate polymer at 50 to 70 ° C. in purified water;
Mixing with a primary capsule formed of semisolid or solid phospholipid nanoparticles; And
Cosmetic capsules comprising the step of encapsulating through a nozzle. The method of claim 8, wherein the primary capsule
Dissolving 5-20 wt% of vegetable higher fatty alcohol or higher fatty acid, 0.1-10 wt% of hydrogenated lecithin, 0.01-5 wt% of soysterol, and 0.1-10 wt% of nonionic or anionic surfactant at 80-100 ° C .;
Mixing the remaining primary capsule material including 30 wt% or less of glycerin, 20 wt% or less of polyol, and purified water to the dissolved component and cooling the mixture to 40 ° C. to 60 ° C .;
Putting the components for encapsulation into the cooled components and stirring for 3 to 10 minutes at 2,000 to 4,000 rpm;
Method for producing a double capsule for cosmetics comprising the step of injecting the stirred component into the microfluidizer 1 to 5 times at a pressure of 1,000 ~ 20,000psi. Cosmetics comprising a double capsule for cosmetics of any one of claims 1 and 3 to 7. 11. The method of claim 10,
Cosmetic double capsule is a cosmetic, characterized in that contained in an amount of 0.01 to 50wt% based on the total weight of the cosmetic composition.

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