CN109511981A - A kind of strengthening the muscles and bones composition and preparation method thereof - Google Patents
A kind of strengthening the muscles and bones composition and preparation method thereof Download PDFInfo
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- CN109511981A CN109511981A CN201811548291.2A CN201811548291A CN109511981A CN 109511981 A CN109511981 A CN 109511981A CN 201811548291 A CN201811548291 A CN 201811548291A CN 109511981 A CN109511981 A CN 109511981A
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Abstract
The invention discloses a kind of strengthening the muscles and bones compositions and preparation method thereof, including step 1: according to each ingredient of parts by weight: Semen sesami nigrum, Chinese yam, pawpaw, cortex cinnamomi, peach kernel, semen coicis, fructus alpiniae oxyphyllae, pueraria lobata, arillus longan, mulberry fruit, raspberry, fructus lycii, rhizoma polygonati and pure water extract after decocting, and obtain extracting solution；Step 2: the extracting solution is concentrated into obtain the thick paste that relative density is 1.20~1.25 (60 DEG C)；Step 3: being dried in vacuo thick paste, gets dry extract；Step 4: being added maltodextrin and dextrin in the dry cream and crush after mixing, 85%~95% ethyl alcohol is then added, then pelletizes, and dry dry particle.Strengthening the muscles and bones composition in the present invention is powdery granule, and boiled water can be taken after washing open.
Description
Technical field
The present invention relates to food processing technology fields more particularly to a kind of strengthening the muscles and bones composition and preparation method thereof.
Background technique
Osteoporosis, hyperplasia etc., are apt to occur in 35 years old or more the middle-aged and the old, and Chinese medicine is referred to as sclerotin retrogression pathological changes.By
It is damaged when daily routines, gradually appears osteoproliferation and Subchondral bone sclerosis.Cervical vertebra, thoracic vertebrae hyperplasia can cause dizziness,
Nausea and vomiting, blurred vision, neck shoulder arm pain and numbness of fingers etc.；The hyperplasia of Thoracolumbar disk can cause lumbocrural pain, numb, living
Dynamic limited or even hemiplegia or pamplegia.Why hyperplasia can be occurred, and Chinese medicine thinks to be caused by kidney qi is deficient."Nei Jing" cloud: " kidney master
Bone, raw marrow ", " five or eight kidney qis decline ".Therefore, people stepped into after the middle age, and kidney qi declines less, and the biochemical weary source of marrow cannot support muscles and bones,
Therefore it is weak and retrogression pathological changes occur iliacus impotence occur, and Bones and joints muscle and limbs is caused tingle swelling and pain occur.
With becoming clear day by day for aging of population, osteoporosis, the illness rate of hyperplasia disease are increasingly increased, therefore in how improving
The muscles and bones of elderly population promotes osteocyte is newborn, repair bone injury, degenerative bone is delayed to have become the world of medicine in recent years to study
Hot spot.
Although effect is not mostly to the greatest extent such as people currently, there are many product on the market about strengthening the muscles and bones, the raw marrow of Psoralen
Meaning, passes through bone resorption inhibitor, estrogen drugs as Western medicine product, and bone remoulding process is made to keep balance, though have one
Constant current modulation effect, but the disadvantages of that there is late results to varying degrees is undesirable, and side effect is big, and drug price is expensive.Therefore, compel
It is essential and wants a kind of clinical efficacy good, safe toxic side effect is small, and patient is easy to the pharmaceutical composition received.
Chinese medicinal formulae is particular about monarch, just records in Shennong's Herbal: " 120 kinds of medicine-feeding are monarch, main to support life；
120 kinds of Chinese medicine are minister, and master nourishs one's nature；Putting in poison 120 kinds makes for assistant, cures mainly disease；Medication must close monarch." " clear
Will is clever " paraphrase: 120 kinds of top grade are monarch, and main life of supporting is nontoxic with Ying Tian, take long term usage more and do not hurt sb.'s feelings, are intended to QI invigorating macrobiosis and make light of one's life by commiting suicide
Angle person, this top grade；120 kinds of middle product are minister, and master nourishs one's nature to answer people, toxic, nontoxic, consider it preferably, qi-restoratives to be cured the disease is thin
Person, it is main in product；Made with 120 kinds of low-grades for assistant, it is mostly malicious to answer ground, can not long term usage, fever and chills perverse trend remove, break accumulation remove it is chronic
Disease person, this low-grade.As it can be seen that being especially particular about the compatibility combination of each medicinal material in the research of Chinese medicine composition, passing through medicine between each medicinal material
The coordinated of effect and pharmacological property, has the function that the toxicity that heightens the effect of a treatment or mitigate.
The present invention combination prior art and application in TCM principle explore a kind of good strengthening the muscles and bones composition.
Summary of the invention
The main object of the present invention is to provide a kind of strengthening the muscles and bones composition, to overcome deficiency present in existing technology.
To achieve the above object, strengthening the muscles and bones composition proposed by the present invention, each ingredient including following parts by weight: black sesame
Numb 10~20 parts, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, 4~8 parts of cortex cinnamomi, 8~16 parts of peach kernel, 8~16 parts of semen coicis, intelligence development
8~16 parts of benevolence, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan, 10~20 parts of mulberry fruit, 7~13 parts of raspberry, fructus lycii 10~20
Part, 10~20 parts of rhizoma polygonati, the strengthening the muscles and bones composition are form of powdery particles.
Further, including each ingredient of following parts by weight: 15 parts of Semen sesami nigrum, 15 parts of Chinese yam, 12 parts of pawpaw, 6 parts of cortex cinnamomi,
12 parts of peach kernel, 12 parts of semen coicis, 12 parts of fructus alpiniae oxyphyllae, 12 parts of pueraria lobata, 15 parts of arillus longan, 15 parts of mulberry fruit, 10 parts of raspberry, fructus lycii
15 parts, 15 parts of rhizoma polygonati.
Further, the peach kernel is Dan peach kernel, and the fructus alpiniae oxyphyllae is stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, and the rhizoma polygonati is to handle by boiling
Steaming rhizoma polygonati.
Further, the strengthening the muscles and bones composition further includes dextrin and maltodextrin.
The present invention also provides a kind of preparation methods of strengthening the muscles and bones composition, comprising the following steps:
Step 1: according to each ingredient of parts by weight: 10~20 parts of Semen sesami nigrum, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, meat
4~8 parts of osmanthus, 8~16 parts of peach kernel, 8~16 parts of semen coicis, 8~16 parts of fructus alpiniae oxyphyllae, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan,
10~20 parts of mulberry fruit, 7~13 parts of raspberry, 10~20 parts of fructus lycii, 10~20 parts of rhizoma polygonati and pure water extract after decocting, and obtain
Obtain extracting solution；
Step 2: the extracting solution is concentrated into obtain the thick paste that relative density is 1.20~1.25 (60 DEG C)；
Step 3: being dried in vacuo thick paste, gets dry extract；
Step 4: being added maltodextrin and dextrin in the dry cream and crush after mixing, then it is added 85%~
95% ethyl alcohol, then pelletizes, and dry dry particle.
Further, the concrete operations of the step 1 are as follows:
It will be according to each ingredient of parts by weight: 10~20 parts of Semen sesami nigrum, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, cortex cinnamomi 4~8
Part, 8~16 parts of peach kernel, 8~16 parts of semen coicis, 8~16 parts of fructus alpiniae oxyphyllae, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan, mulberry fruit 10
~20 parts, 7~13 parts of raspberry, 10~20 parts of fructus lycii, 10~20 parts of rhizoma polygonati and the first parts by weight of purified water the is carried out after decocting
Once extracts and obtain first extract；
First extract is filtered, obtains first extracting solution and filter residue respectively, filter residue is placed in, the second weight is added
Part pure water, is extracted for the second time and obtains second extract；
Second extract is filtered, secondary raffinate and filter residue are obtained respectively, by first extracting solution and second extraction
Liquid, which merges, obtains the extracting solution.
Further, the concrete operations of the step 2 are as follows:
The extracting solution is concentrated under reduced pressure into obtain the thick paste that relative density is 1.20~1.25 (60 DEG C).
Further, the thickening temperature being concentrated under reduced pressure in the step 2 is 70 DEG C~80 DEG C, and pressure value is -0.06MPa
~-0.08MPa；In the step 3 vacuum drying drying temperature be 65 DEG C~75 DEG C, pressure value be -0.06MPa~-
0.08MPa。
Further, the step 4 specifically includes:
According to dry cream: dextrin: maltodextrin=5: 5~7: 2~4, maltodextrin is added in the dry cream and dextrin is mixed
It is crushed after closing uniformly, 85%~95% ethyl alcohol containing Sucralose is then added, then pelletizes, and fluidized drying must be done
Dry particle.
Further, first parts by weight of purified water is 7-10 times of each total weight at the mixture being grouped as and measures；Institute
Stating the second parts by weight of purified water is respectively to measure at 5-8 times of the total weight for the mixture being grouped as in step 1.
The Semen sesami nigrum in strengthening the muscles and bones composition in the present invention, mulberry fruit, fructus lycii, rhizoma polygonati, pawpaw, it is nourishing liver and kidney, it fills out
Smart mends marrow, strengthening the muscles and bones promote osteocyte newborn, delay degenerative bone；Cortex cinnamomi, fructus alpiniae oxyphyllae, raspberry, treating YIN within YANG, temperature compensation
Kidney yang, controlling nocturnal emission with astringent drugs are only lost；Chinese yam, arillus longan, blood of invigorating the spleen and benefiting qi, as a means of essence and blood of supplementing nutrition；Peach kernel, pueraria lobata, blood circulation promoting and enriching repair bone damage
Wound.All medicines close 5, and replenishing kidney and strengthening bone promotes osteocyte new life, repairs bone injury, delays degenerative bone, move back suitable for all kinds of sclerotin
Row venereal disease becomes the health care of crowd, excellent.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff every other embodiment obtained without creative efforts belongs to what the present invention protected
Range.
It in addition, the technical solution between each embodiment of the present invention can be combined with each other, but must be general with this field
Based on logical technical staff can be realized, it will be understood that when the combination of technical solution appearance is conflicting or cannot achieve this
The combination of technical solution is not present, also not the present invention claims protection scope within.
The present invention proposes a kind of strengthening the muscles and bones composition, which includes each ingredient of following parts by weight:
10~20 parts of Semen sesami nigrum, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, 4~8 parts of cortex cinnamomi, 8~16 parts of peach kernel, 8~16 parts of semen coicis,
8~16 parts of fructus alpiniae oxyphyllae, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan, 10~20 parts of mulberry fruit, 7~13 parts of raspberry, fructus lycii 10
~20 parts, 10~20 parts of rhizoma polygonati, the strengthening the muscles and bones composition are form of powdery particles.
Semen sesami nigrum, mulberry fruit in strengthening the muscles and bones composition provided by the invention, fructus lycii, rhizoma polygonati, pawpaw, it is nourishing liver and kidney,
Tianjing Busuiye medicinal, strengthening the muscles and bones promote osteocyte newborn, delay degenerative bone；Cortex cinnamomi, fructus alpiniae oxyphyllae, raspberry, treating YIN within YANG, temperature
Kidney-replenishing, controlling nocturnal emission with astringent drugs are only lost；Chinese yam, arillus longan, blood of invigorating the spleen and benefiting qi, as a means of essence and blood of supplementing nutrition；Peach kernel, pueraria lobata, blood circulation promoting and enriching repair bone
Damage.All medicines close 5, and replenishing kidney and strengthening bone promotes osteocyte new life, repairs bone injury, delays degenerative bone, are suitable for all kinds of sclerotin
The health care of retrogression pathological changes crowd, excellent.
It should be noted that the peach kernel is Dan peach kernel, the fructus alpiniae oxyphyllae is stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, and the rhizoma polygonati is by boiling
The steaming rhizoma polygonati of processing.Peach kernel is placed in boiling water, heating, which is boiled to micro- swell of kind of skin, to be pulled out, is slightly steeped, is picked up in cold water, is rubbed open
Kind skin and kernel, dry, kind of skin of winnowing with a dustpan eliminates non-medicinal part up to Dan peach kernel, and active principle is easy to fried, improves medicine
Effect.Fructus alpiniae oxyphyllae is mixed thoroughly with salt water, micro- stir-fry, taking-up cools, and obtains stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, and stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution is selected to be easier to be used as medicine.By
The rhizoma polygonati of boiling processing eliminates the numb taste of rhizoma polygonati, the effect of being avoided that stimulation throat, be likewise supplied with invigorating the spleen moistening lung, kidney-nourishing.
Further, the strengthening the muscles and bones composition further includes dextrin and/or maltodextrin, to improve composition grain
Viscosity, make it have certain viscosity and be readily soluble in water again.
Further, strengthening the muscles and bones composition proposed by the present invention preparation method the following steps are included:
Step 1: according to each ingredient of parts by weight: 10~20 parts of Semen sesami nigrum, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, meat
4~8 parts of osmanthus, 8~16 parts of peach kernel, 8~16 parts of semen coicis, 8~16 parts of fructus alpiniae oxyphyllae, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan,
10~20 parts of mulberry fruit, 7~13 parts of raspberry, 10~20 parts of fructus lycii, 10~20 parts of rhizoma polygonati and pure water extract after decocting, and obtain
Obtain extracting solution；
Step 2: the extracting solution is concentrated into obtain the thick paste that relative density is 1.20~1.25 (60 DEG C)；
Step 3: being dried in vacuo thick paste, gets dry extract；
Step 4: being added maltodextrin and dextrin in the dry cream and crush after mixing, then it is added 85%~
95% ethyl alcohol, then pelletizes, and dry dry particle.
It is understood that can also include the technologies of the package such as whole grain sieving, Nei Bao and outsourcing after the step 4.
Strengthening the muscles and bones composition proposed by the present invention and preparation method thereof is carried out specifically below by way of specific embodiment
It is bright:
Embodiment one
A kind of strengthening the muscles and bones composition, each ingredient including following parts by weight: 15 parts of Semen sesami nigrum, 15 parts of Chinese yam, pawpaw 12
Part, 12 parts of Dan peach kernel, 12 parts of semen coicis, 12 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, 12 parts of pueraria lobata, 15 parts of arillus longan, 15 parts of mulberry fruit, is covered 6 parts of cortex cinnamomi
10 portions of basin, steams 15 parts of rhizoma polygonati at 15 parts of fructus lycii.
The preparation method of the strengthening the muscles and bones composition the following steps are included:
Step 1: above-mentioned each ingredient: Semen sesami nigrum 150g, Chinese yam 150g, pawpaw 120g, cortex cinnamomi 60g, Dan peach kernel is weighed respectively
120g, semen coicis 120g, stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution 120g, pueraria lobata 120g, arillus longan 150g, mulberry fruit 150g, raspberry 100g, fructus lycii
150g, the mixture for steaming rhizoma polygonati 150g, said mixture is placed in extractor, and 8 times of amount parts of said mixture total weight are added
Pure water, setting Extracting temperature be 100 DEG C, extract 120 minutes, carry out 300 mesh filter screen filterings, obtain respectively first extracting solution and
Filter residue is placed in extractor by filter residue, and the pure water of 6 times of total weight of the mixture amount parts in step 1 is added, and Extracting temperature is arranged
Be 100 degree, extract 60 minutes, carry out 300 mesh filter screen filterings, obtain secondary raffinate and filter residue respectively, by first extracting solution with
Secondary raffinate, which merges, obtains extracting solution；
Step 2: extracting solution is concentrated under reduced pressure to (temperature: 70~80 DEG C, vacuum degree: -0.06~-0.08Mpa) to phase
It is the thick paste of 1.20~1.25 (60 DEG C) to density；
Step 3: carrying out 100 mesh filter screen filterings to thick paste, and be dried in vacuo (temperature: 65~75 DEG C, vacuum degree: -0.06
~-0.08Mpa), get dry extract about 370g；
Step 4: using granulation, drying, whole grain, particle yield as inspection target, determine that the dry cream auxiliary material ratio of this product is dry
Cream: dextrin: maltodextrin=5: 6: 3；Dextrin about 440g is added, maltodextrin about 220g is ground into fine powder (80 mesh)；It adds
Dissolved with 87% ethanol solution 130ml of 0.6g Sucralose, then pelletize, and fluidized drying to water content less than 5%,
12~14 mesh sieves obtain dry particle 1000g.
Embodiment two
A kind of strengthening the muscles and bones composition, each ingredient including following parts by weight: 10 parts of Semen sesami nigrum, 10 parts of Chinese yam, pawpaw 8
Part, 4 parts of cortex cinnamomi, 8 parts of peach kernel, 8 parts of semen coicis, 8 parts of fructus alpiniae oxyphyllae, 16 parts of pueraria lobata, 20 parts of arillus longan, 20 parts of mulberry fruit, raspberry 13
Part, 20 parts of fructus lycii, 20 parts of rhizoma polygonati.
The preparation method of the strengthening the muscles and bones composition the following steps are included:
Step 1: above-mentioned each ingredient: 10 parts of Semen sesami nigrum, 10 parts of Chinese yam, 8 parts of pawpaw, 4 parts of cortex cinnamomi, peach kernel 8 is weighed respectively
Part, 8 parts of semen coicis, 8 parts of fructus alpiniae oxyphyllae, 16 parts of pueraria lobata, 20 parts of arillus longan, 20 parts of mulberry fruit, 13 parts of raspberry, 20 parts of fructus lycii, Huang
The mixture of 20 parts of essence, said mixture is placed in extractor, and the pure water of 10 times of said mixture total weight amount parts is added, if
Setting Extracting temperature is 100 DEG C, is extracted 120 minutes, carries out 300 mesh filter screen filterings, obtains first extracting solution and filter residue respectively, will filter
Slag is placed in extractor, and the pure water of 8 times of total weight of the mixture amount parts in step 1 is added, and setting Extracting temperature is 100 degree, is mentioned
It takes 60 minutes, carries out 300 mesh filter screen filterings, secondary raffinate and filter residue are obtained respectively, by first extracting solution and secondary raffinate
Merge and obtains extracting solution；
Step 2: it is centrifuged said extracted liquid to obtain supernatant；Then by supernatant be concentrated under reduced pressure (temperature: 70~
80 DEG C, vacuum degree: -0.06~-0.08Mpa) to relative density be 1.20~1.25 (60 DEG C) thick paste；
Step 3: thick paste is dried in vacuo (temperature: 65~75 DEG C, vacuum degree: -0.06~-0.08Mpa), obtain dry
Cream；
Step 4: using granulation, drying, whole grain, particle yield as inspection target, determine that the dry cream auxiliary material ratio of this product is dry
Cream: dextrin: maltodextrin=5: 5: 4；It is proportionally added into dextrin, maltodextrin and is ground into fine powder (80 mesh)；Add dissolved with
85% ethanol solution of Sucralose, then pelletizes, and fluidized drying is whole less than 5%, 12~14 mesh to water content
Grain, obtains dry particle.
Embodiment three
A kind of strengthening the muscles and bones composition, each ingredient including following parts by weight: 20 parts of Semen sesami nigrum, 20 parts of Chinese yam, pawpaw 16
Part, 8 parts of cortex cinnamomi, 16 parts of peach kernel, 16 parts of semen coicis, 16 parts of fructus alpiniae oxyphyllae, 8 parts of pueraria lobata, 10 parts of arillus longan, 10 parts of mulberry fruit, raspberry 7
Part, 10 parts of fructus lycii, 10 parts of rhizoma polygonati.
The preparation method of the strengthening the muscles and bones composition the following steps are included:
Step 1: above-mentioned each ingredient: 20 parts of Semen sesami nigrum, 20 parts of Chinese yam, 16 parts of pawpaw, 8 parts of cortex cinnamomi, peach kernel 16 is weighed respectively
Part, 16 parts of semen coicis, 16 parts of fructus alpiniae oxyphyllae, 8 parts of pueraria lobata, 10 parts of arillus longan, 10 parts of mulberry fruit, 7 parts of raspberry, 10 parts of fructus lycii, Huang
The mixture of 10 parts of essence, said mixture is placed in extractor, and the pure water of 7 times of said mixture total weight amount parts is added, if
Setting Extracting temperature is 100 DEG C, is extracted 120 minutes, carries out 300 mesh filter screen filterings, obtains first extracting solution and filter residue respectively, will filter
Slag is placed in extractor, and the pure water of 5 times of total weight of the mixture amount parts in step 1 is added, and setting Extracting temperature is 100 degree, is mentioned
It takes 60 minutes, carries out 300 mesh filter screen filterings, secondary raffinate and filter residue are obtained respectively, by first extracting solution and secondary raffinate
Merge and obtains extracting solution；
Step 2: it is centrifuged said extracted liquid to obtain supernatant；Then by supernatant be concentrated under reduced pressure (temperature: 70~
80 DEG C, vacuum degree: -0.06~-0.08Mpa) to relative density be 1.20~1.25 (60 DEG C) thick paste；
Step 3: thick paste is dried in vacuo (temperature: 65~75 DEG C, vacuum degree: -0.06~-0.08Mpa), obtain dry
Cream；
Step 4: using granulation, drying, whole grain, particle yield as inspection target, determine that the dry cream auxiliary material ratio of this product is dry
Cream: dextrin: maltodextrin=5: 7: 2；It is proportionally added into dextrin, maltodextrin and is ground into fine powder (80 mesh)；Add dissolved with
90% ethanol solution of Sucralose, then pelletizes, and fluidized drying is whole less than 5%, 12~14 mesh to water content
Grain, obtains dry particle.
Example IV
A kind of strengthening the muscles and bones composition, each ingredient including following parts by weight: 20 parts of Semen sesami nigrum, 10 parts of Chinese yam, pawpaw 16
Part, 16 parts of Dan peach kernel, 8 parts of semen coicis, 16 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, 8 parts of pueraria lobata, 20 parts of arillus longan, 10 parts of mulberry fruit, covers basin at 4 parts of cortex cinnamomi
13 portions of son, steams 20 parts of rhizoma polygonati at 10 parts of fructus lycii.
The preparation method of the strengthening the muscles and bones composition the following steps are included:
Step 1: above-mentioned each ingredient: 20 parts of Semen sesami nigrum, 10 parts of Chinese yam, 16 parts of pawpaw, 4 parts of cortex cinnamomi, Dan peach kernel is weighed respectively
16 parts, 8 parts of semen coicis, 16 parts of stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, 8 parts of pueraria lobata, 20 parts of arillus longan, 10 parts of mulberry fruit, 13 parts of raspberry, fructus lycii 10
Part, the mixture for steaming 20 parts of rhizoma polygonati, said mixture is placed in extractor, and 10 times of said mixture total weight amount parts are added
Pure water, setting Extracting temperature are 100 DEG C, extract 120 minutes, carry out 300 mesh filter screen filterings, obtain first extracting solution and filter respectively
Filter residue is placed in extractor by slag, and the pure water of 5 times of total weight of the mixture amount parts in step 1 is added, and setting Extracting temperature is
It 100 degree, extracts 60 minutes, carries out 300 mesh filter screen filterings, secondary raffinate and filter residue are obtained respectively, by first extracting solution and two
Secondary extracting solution, which merges, obtains extracting solution；
Step 2: it is centrifuged said extracted liquid to obtain supernatant；Then by supernatant be concentrated under reduced pressure (temperature: 70~
80 DEG C, vacuum degree: -0.06~-0.08Mpa) to relative density be 1.20~1.25 (60 DEG C) thick paste；
Step 3: carrying out 100 mesh filter screen filterings to thick paste, and be dried in vacuo (temperature: 65~75 DEG C, vacuum degree: -0.06
~-0.08Mpa), it gets dry extract；
Step 4: using granulation, drying, whole grain, particle yield as inspection target, determine that the dry cream auxiliary material ratio of this product is dry
Cream: dextrin: maltodextrin=5: 6: 3；It is proportionally added into dextrin, maltodextrin and is ground into fine powder (80 mesh)；Add dissolved with
87% ethanol solution of Sucralose, then pelletizes, and fluidized drying is whole less than 5%, 12~14 mesh to water content
Grain, obtains dry particle.
Embodiment five
A kind of strengthening the muscles and bones composition, each ingredient including following parts by weight: 15 parts of Semen sesami nigrum, 15 parts of Chinese yam, pawpaw 12
Part, 6 parts of cortex cinnamomi, 12 parts of peach kernel, 12 parts of semen coicis, 12 parts of fructus alpiniae oxyphyllae, 12 parts of pueraria lobata, 15 parts of arillus longan, 15 parts of mulberry fruit, raspberry
10 parts, 15 parts of fructus lycii, 15 parts of rhizoma polygonati.
The preparation method of the strengthening the muscles and bones composition the following steps are included:
Step 1: above-mentioned each ingredient: 15 parts of Semen sesami nigrum, 15 parts of Chinese yam, 12 parts of pawpaw, 6 parts of cortex cinnamomi, peach kernel 12 is weighed respectively
Part, 12 parts of semen coicis, 12 parts of fructus alpiniae oxyphyllae, 12 parts of pueraria lobata, 15 parts of arillus longan, 15 parts of mulberry fruit, 10 parts of raspberry, 15 parts of fructus lycii,
The mixture that 15 parts of rhizoma polygonati, said mixture is placed in extractor, and the pure water of 8 times of said mixture total weight amount parts is added,
It is 100 DEG C that Extracting temperature, which is arranged, is extracted 120 minutes, carries out 300 mesh filter screen filterings, obtains first extracting solution and filter residue respectively, will
Filter residue is placed in extractor, and the pure water of 6 times of total weight of the mixture amount parts in step 1 is added, and setting Extracting temperature is 100 degree,
It extracts 60 minutes, carries out 300 mesh filter screen filterings, secondary raffinate and filter residue are obtained respectively, by first extracting solution and second extraction
Liquid, which merges, obtains extracting solution；
Step 2: it is centrifuged said extracted liquid to obtain supernatant；Then by supernatant be concentrated under reduced pressure (temperature: 70~
80 DEG C, vacuum degree: -0.06~-0.08Mpa) to relative density be 1.20~1.25 (60 DEG C) thick paste；
Step 3: thick paste is dried in vacuo (temperature: 65~75 DEG C, vacuum degree: -0.06~-0.08Mpa), obtain dry
Cream；
Step 4: using granulation, drying, whole grain, particle yield as inspection target, determine that the dry cream auxiliary material ratio of this product is dry
Cream: dextrin: maltodextrin=5: 6: 3；It is proportionally added into dextrin, maltodextrin and is ground into fine powder (80 mesh)；Add dissolved with
87% ethanol solution of Sucralose, then pelletizes, and fluidized drying is whole less than 5%, 12~14 mesh to water content
Grain, obtains dry particle.
Clinical test is carried out to strengthening the muscles and bones composition below:
1, osteoproliferation curative effect is tested
There is cervical vertebra, hyperplasia patient 180 of thoracic vertebrae in the selection stage at 35~55 years old age, and cardinal symptom shows as dizzy
Dizzy, Nausea and vomiting, blurred vision, neck shoulder arm pain and the numbness of fingers etc., are randomly divided into 6 groups, every group of 30 people, first 5 groups take respectively
With the strengthening the muscles and bones composition electuary in Examples 1 to 5, the 6th group is taken equivalent blank placebo.Wherein in Examples 1 to 5
Strengthening the muscles and bones composition is one 1 bag of dosage, every bag of 10g, respectively takes 1 bag on an empty stomach within 1 hour before meals sooner or later.After taking one month
The symptomatic condition of user is investigated, structure is investigated and please refers to table 1.
The symptom of 1 user of table, which improves, investigates result
| Experimental group | 1st group | 2nd group | 3rd group | 4th group | 5th group | 6th group |
| Dizziness improves | 26 | 20 | 23 | 24 | 22 | 2 |
| Vomiting improves | 25 | 22 | 20 | 24 | 21 | 1 |
| Blurred vision improves | 26 | 20 | 21 | 25 | 23 | 1 |
| Pain improves | 27 | 22 | 22 | 25 | 24 | 2 |
| The numbness of fingers improves | 26 | 23 | 22 | 24 | 22 | 2 |
Typical treatment case:
Patient one, male, and 45 years old, Symptoms were dizziness, Nausea and vomiting, with neck-shoulder pain, and tcm diagnosis moves back for sclerotin
Row venereal disease becomes.X-ray film is shown: stenosis of disc space, spinal canal stenosis, and poerior aspect of vertebral body is formed.Now take the system of the embodiment of the present invention 1
Standby obtained strengthening the muscles and bones solid beverage, twice a day, a 10g are taken for one hour before meals sooner or later, good after taking three months
Turn, continues the above symptom after taking three months and disappear.Checked X-ray film to show: poerior aspect of vertebral body disappears.
Patient two, female, and 52 years old, Symptoms were nausea, blurred vision, the numbness of fingers, and tcm diagnosis is sclerotin degeneration
Lesion.Carotid ultrasonography is shown: left side PSV is 30.1cm/s, EDV 13.8cm/s；Right side PSV is 27.4cm/s, and EDV is
8.9cm/s.The strengthening the muscles and bones solid beverage that the embodiment of the present invention 2 is prepared now is taken, twice a day, a 10g, early supper
Previous hour takes, and effect is obvious after taking half a year, continues the above symptom after taking half a year and disappears substantially.Check Carotid ultrasonography
Display: left side PSV is 40.6cm/s, EDV 15.7cm/s；Right side PSV is 35.2cm/s, EDV 13.6cm/s.
Patient three, male, and 37 years old, Symptoms were that neck rotation has snap, and stiff to ache, headache and dizziness, X-ray film shows: neck
The obvious hyperplasia deformation of vertebra, has little effect repeatedly through multi-party medical conditions.Carotid ultrasonography is shown: left side PSV is 52.0cm/s,
EDV is 15.7cm/s；Right side PSV is 49.5cm/s, EDV 14.3cm/s.Now take the embodiment of the present invention 3 be prepared it is strong
Muscle strong bone solid beverage, twice a day, a 10g are taken for one hour before meals sooner or later, and the symptoms were significantly improved after taking three months,
Continue the above symptom after taking three months to disappear substantially.Check Carotid ultrasonography is shown: left side PSV is 60.1cm/s, and EDV is
17.3cm/s；Right side PSV is 55.8cm/s, EDV 16.9cm/s.
2, osteoporosis curative effect is tested
The selection stage at 45~65 years old age occurs patient 180 of osteoporosis, and cardinal symptom shows as lumbago, camel
Back, expiratory dyspnea etc., are randomly divided into 6 groups, every group of 30 people, the first 5 groups strengthening the muscles and bones compositions taken in Examples 1 to 5 respectively
Electuary, the 6th group is taken equivalent blank placebo.Wherein the strengthening the muscles and bones composition in Examples 1 to 5 is one 1 bag of dosage,
Every bag of 10g respectively takes 1 bag in 1 hour before meals sooner or later on an empty stomach.The symptomatic condition of user is investigated after taking three months, is examined
It examines structure and please refers to table 1.
The symptom of 2 user of table, which improves, investigates result
| Experimental group | 1st group | 2nd group | 3rd group | 4th group | 5th group | 6th group |
| Lumbago improves | 27 | 22 | 20 | 24 | 23 | 1 |
| Hunchback improves | 23 | 18 | 16 | 20 | 19 | 0 |
| Expiratory dyspnea improves | 26 | 24 | 23 | 23 | 20 | 1 |
Table 3 is please referred to, table 3 is the conventional inspection taken after solid beverage three months of strengthening the muscles and bones composition composition of the present invention
Survey table.
3 patient of table takes the bone conventional detection table of front and back
The solid beverage being made of the strengthening the muscles and bones composition that table 1-3 can be observed to prepare in the present embodiment, for sclerotin
Hyperplasia and sufferers of osteoporosis face have clear improvement, and obviously nothing is suitable for all kinds of sclerotin retrogression pathological changes crowds repeatedly to effect
Health care.
The above case show strengthening the muscles and bones solid beverage provided by the invention have replenishing kidney and strengthening bone, promote osteocyte it is newborn,
It repairs bone injury, delay degenerative bone and other effects, for that cannot heal for a long time to senile fracture and the bones such as caput femoris necrosis damage
The patient of wound and osteoporosis, the longer effect of Time of Administration are better.Strengthening the muscles and bones solid beverage provided by the invention faces simultaneously
Bed does not find adverse reaction, and drug safety is reliable.
In the description of this specification, reference term " embodiment ", " another embodiment ", " other embodiments " or "
The description of one embodiment~X embodiment " etc. mean specific features described in conjunction with this embodiment or example, structure, material or
Person's feature is included at least one embodiment or example of the invention.In the present specification, to the schematic table of above-mentioned term
Stating may not refer to the same embodiment or example.Moreover, specific features, structure, material, method and step or the spy of description
Point can be combined in any suitable manner in any one or more of the embodiments or examples.
It should be noted that, in this document, the terms "include", "comprise" or its any other variant are intended to non-row
His property includes, so that the process, method, article or the device that include a series of elements not only include those elements, and
And further include other elements that are not explicitly listed, or further include for this process, method, article or device institute it is intrinsic
Element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that including being somebody's turn to do
There is also other identical elements in the process, method of element, article or device.
The serial number of the above embodiments of the invention is only for description, does not represent the advantages or disadvantages of the embodiments.
The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to preferred embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that, it can modify to technical solution of the present invention
Or equivalent replacement should all cover without departing from the objective and range of technical solution of the present invention in claim of the invention
In range.
Claims (10)
1. a kind of strengthening the muscles and bones composition, which is characterized in that each ingredient including following parts by weight: 10~20 parts of Semen sesami nigrum, mountain
10~20 parts of medicine, 8~16 parts of pawpaw, 4~8 parts of cortex cinnamomi, 8~16 parts of peach kernel, 8~16 parts of semen coicis, 8~16 parts of fructus alpiniae oxyphyllae, Pueraria lobota
8~16 parts of root, 10~20 parts of arillus longan, 10~20 parts of mulberry fruit, 7~13 parts of raspberry, 10~20 parts of fructus lycii, rhizoma polygonati 10~20
Part, the strengthening the muscles and bones composition is form of powdery particles.
2. strengthening the muscles and bones composition as described in claim 1, which is characterized in that each ingredient including following parts by weight: black sesame
Numb 15 parts, 15 parts of Chinese yam, 12 parts of pawpaw, 6 parts of cortex cinnamomi, 12 parts of peach kernel, 12 parts of semen coicis, 12 parts of fructus alpiniae oxyphyllae, 12 parts of pueraria lobata, longan
15 parts of meat, 15 parts of mulberry fruit, 10 parts of raspberry, 15 parts of fructus lycii, 15 parts of rhizoma polygonati.
3. strengthening the muscles and bones composition as claimed in claim 1 or 2, which is characterized in that the peach kernel is Dan peach kernel, the intelligence development
Benevolence is stir-baked FRUCTUS ALPINIAE OXY-PHYLLAE after sprinking salt solution, and the rhizoma polygonati is the steaming rhizoma polygonati handled by boiling.
4. strengthening the muscles and bones composition as claimed in claim 1 or 2, which is characterized in that the strengthening the muscles and bones composition further includes
Dextrin and maltodextrin.
5. a kind of preparation method of strengthening the muscles and bones composition, which comprises the following steps:
Step 1: according to each ingredient of parts by weight: 10~20 parts of Semen sesami nigrum, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, cortex cinnamomi 4~
8 parts, 8~16 parts of peach kernel, 8~16 parts of semen coicis, 8~16 parts of fructus alpiniae oxyphyllae, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan, mulberry fruit 10
~20 parts, 7~13 parts of raspberry, 10~20 parts of fructus lycii, 10~20 parts of rhizoma polygonati and pure water extract after decocting, and are extracted
Liquid；
Step 2: the extracting solution is concentrated into obtain the thick paste that relative density is 1.20~1.25 (60 DEG C)；
Step 3: being dried in vacuo thick paste, gets dry extract；
Step 4: being added maltodextrin in the dry cream and dextrin crush after mixing, and 85%~95% second is then added
Then alcohol is pelletized, and dry dry particle.
6. the preparation method of strengthening the muscles and bones composition as claimed in claim 5, which is characterized in that the specific behaviour of the step 1
As:
Will be according to each ingredient of parts by weight: 10~20 parts of Semen sesami nigrum, 10~20 parts of Chinese yam, 8~16 parts of pawpaw, 4~8 parts of cortex cinnamomi,
8~16 parts of peach kernel, 8~16 parts of semen coicis, 8~16 parts of fructus alpiniae oxyphyllae, 8~16 parts of pueraria lobata, 10~20 parts of arillus longan, mulberry fruit 10~20
Part, 7~13 parts of raspberry, 10~20 parts of fructus lycii, 10~20 parts of rhizoma polygonati and the first parts by weight of purified water carry out for the first time after decocting
It extracts and obtains first extract；
First extract is filtered, obtains first extracting solution and filter residue respectively, it is pure that filter residue is placed in the second parts by weight of addition
Water is extracted for the second time and obtains second extract；
Second extract is filtered, obtains secondary raffinate and filter residue respectively, first extracting solution and secondary raffinate are closed
And obtain the extracting solution.
7. the preparation method of strengthening the muscles and bones composition as claimed in claim 5, which is characterized in that the specific behaviour of the step 2
As:
The extracting solution is concentrated under reduced pressure into obtain the thick paste that relative density is 1.20~1.25 (60 DEG C).
8. the preparation method of strengthening the muscles and bones composition as claimed in claim 7, which is characterized in that depressurized in the step 2 dense
The thickening temperature of contracting is 70 DEG C~80 DEG C, and pressure value is -0.06MPa~-0.08MPa；It is vacuum drying dry in the step 3
Dry temperature is 65 DEG C~75 DEG C, and pressure value is -0.06MPa~-0.08MPa.
9. the preparation method of strengthening the muscles and bones composition as claimed in claim 5, which is characterized in that the step 4 is specifically wrapped
It includes:
According to dry cream: dextrin: maltodextrin=5: 5~7: 2~4, maltodextrin is added in the dry cream and dextrin mixing is equal
It is crushed after even, 85%~95% ethyl alcohol containing Sucralose is then added, then pelletizes, and fluidized drying must be dried
Grain.
10. the preparation method of strengthening the muscles and bones composition as claimed in claim 6, which is characterized in that first parts by weight are pure
Water is that 7-10 times of each total weight at the mixture being grouped as is measured；Second parts by weight of purified water is in step 1 respectively at grouping
At 5-8 times of total weight of mixture measure.
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| CN108795672A (en) * | 2018-07-06 | 2018-11-13 | 遵义市红花岗区仁汇中草药研究所 | Kidney-tonifying wine and preparation method thereof |
| CN110038102A (en) * | 2019-05-22 | 2019-07-23 | 黄晓明 | Warming and invigorating kidney Yang Tea containing traditional Chinese medicine for health care and preparation method and system and drinking method |
| CN110870570A (en) * | 2019-11-25 | 2020-03-10 | 类红缨 | Edible granule for strengthening tendons and bones and preparation method thereof |
| CN114028535A (en) * | 2021-12-16 | 2022-02-11 | 重庆希尔安药业有限公司 | Selenium-rich earthworm protein composition for promoting fracture healing and preparation method thereof |
| CN115779039A (en) * | 2023-01-30 | 2023-03-14 | 云南中医药大学 | Medicine-food homologous composition for improving bone mineral density based on regulation of intestinal fungus metabolism |
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| CN108795672A (en) * | 2018-07-06 | 2018-11-13 | 遵义市红花岗区仁汇中草药研究所 | Kidney-tonifying wine and preparation method thereof |
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| CN110870570A (en) * | 2019-11-25 | 2020-03-10 | 类红缨 | Edible granule for strengthening tendons and bones and preparation method thereof |
| CN114028535A (en) * | 2021-12-16 | 2022-02-11 | 重庆希尔安药业有限公司 | Selenium-rich earthworm protein composition for promoting fracture healing and preparation method thereof |
| CN114028535B (en) * | 2021-12-16 | 2023-12-15 | 重庆希尔安药业有限公司 | Selenium-enriched earthworm protein composition for promoting fracture healing and preparation method thereof |
| CN115779039A (en) * | 2023-01-30 | 2023-03-14 | 云南中医药大学 | Medicine-food homologous composition for improving bone mineral density based on regulation of intestinal fungus metabolism |
| CN115779039B (en) * | 2023-01-30 | 2023-05-16 | 云南中医药大学 | Pharmaceutical composition for treating postmenopausal osteoporosis |
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Application publication date: 20190326 |