CN109499405A - The emulsification mechanism of liposome - Google Patents
The emulsification mechanism of liposome Download PDFInfo
- Publication number
- CN109499405A CN109499405A CN201811643682.2A CN201811643682A CN109499405A CN 109499405 A CN109499405 A CN 109499405A CN 201811643682 A CN201811643682 A CN 201811643682A CN 109499405 A CN109499405 A CN 109499405A
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- CN
- China
- Prior art keywords
- agitating shaft
- liner
- bottom end
- portioning layer
- internal portioning
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/80—Mixers with rotating receptacles rotating about a substantially vertical axis
- B01F29/83—Mixers with rotating receptacles rotating about a substantially vertical axis with rotary paddles or arms, e.g. movable out of the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/123—Maintenance of mixers using mechanical means using scrapers for cleaning mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/51—Mixing receptacles characterised by their material
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention discloses the emulsification mechanisms of the liposome in emulsifying device field, including emulsion pot and blender, emulsion pot includes shell and liner, the bottom of liner is equipped with spline, and shell includes connecting cylinder and support base, and support base includes internal portioning layer and outer jacket, the bottom of internal portioning layer is equipped with through-hole, spline platform is equipped between internal portioning layer and outer jacket, spline platform is circumferential integrally formed with multiple interrays positioned at internal portioning layer and outer jacket, and the top of spoke has by moving magnet；Connecting cylinder is connected to the top of support base, vertically communicated annular gap is equipped in connecting cylinder side wall, blender is connected to the top of connecting cylinder, blender includes agitating shaft, the bottom end of blender is equipped with the driving member for protruding into annular gap, and driving member and stirring axis connection, driving member are opposite with the rotation direction of agitating shaft, driving member bottom end also is provided with active magnet, opposite with active magnet top polarity by moving magnet bottom end polarity.The present invention can improve the low problem of present level stirring and emulsifying technology emulsifying power.
Description
Technical field
The present invention relates to emulsifying device fields, and in particular to a kind of emulsification mechanism of liposome.
Background technique
Liposome (liposome) is a kind of artificial membrane.In water in phospholipid molecule hydrophilic head insertion water, liposome is dredged
Air is stretched in water tail portion, and the spherical liposomes of the double-deck rouge molecule are formed after agitation, and 25~1000nm of diameter is differed.Liposome is available
In transgenosis or prepare drug, using liposome can and the characteristics of cell membrane fusion, drug is sent into cell interior biology
Definition: when amphiphatic molecule such as phosphatide and sphingolipid are scattered in water phase, the hydrophobic tail of molecule is tended to flock together, and avoids water
Phase, and hydrophilic head is exposed to water phase, forms the vesicle with bilayer structure, referred to as liposome.
The processing of liposome is usually that moisture is added simultaneously in lipid phase high-speed stirred, forms butterfat under mixing
Shape, as emulsion process.Existing emulsifying manner mainly has ultrasonic water bath, homogenizer, probe sonication and high-speed stirred, the most frequently used
Be high-speed stirred, its main cost is relatively lower, using more commonly.But high-speed stirred is mainly the stirring of macroscopic view, and by
It is limited to the factors such as the mechanical strength performance of power of motor, stirring structure, so that emulsifying effectiveness and efficiency are relatively poor.
Summary of the invention
It is low to improve present level stirring and emulsifying technology emulsifying power the invention is intended to provide the emulsification mechanism of liposome
Problem.
In order to achieve the above objectives, basic technology scheme of the invention is as follows: the emulsification mechanism of liposome, including emulsion pot and
Blender, emulsion pot include shell and liner, and the exterior bottom of liner is equipped with spline, and shell includes connecting cylinder and support base,
Support base includes internal portioning layer and outer jacket, is equipped with screw thread, the bottom of internal portioning layer on the apical lateral wall of internal portioning layer and outer jacket
Equipped with through-hole corresponding with spline, spline platform is equipped between internal portioning layer and outer jacket, the lower part of spline platform is circumferentially radial
Integrally formed with the spoke of multiple arcs, between internal portioning layer and outer jacket, the top of each spoke is equipped with passively spoke
Magnet；Connecting cylinder is detachably connected on the top of support base, is equipped with vertically communicated annular gap, blender in connecting cylinder side wall
It is detachably connected on the top of connecting cylinder, blender includes agitating shaft, and the bottom end of blender is equipped with the transmission for protruding into annular gap
Part, driving member and stirring axis connection, the rotation direction of driving member and the rotation direction of agitating shaft are on the contrary, driving member bottom end also is provided with
Active magnet, it is opposite with active magnet top polarity by moving magnet bottom end polarity.
The principle of this programme is: when practical application, emulsion pot is stirred for containing liposome and providing stirring and emulsifying space
Device is used to carry out the liposome in emulsion pot high-speed stirred emulsification, and the liner of emulsion pot is as the appearance for directly containing liposome
Device, connectivity port of the spline as liner, shell is as the external support of emulsion pot, isolation and protection structure.Connecting cylinder is used
In connection blender and support base, lower support structure of the support base as shell, internal portioning layer is as the protection knot on the outside of liner
The support construction of structure and when not in use liner, outer jacket as the emulsification outermost protection structure of pot bottom, through-hole as it is interior every
Connectivity port on layer, support and power transmission part of the spline platform as liner cooperate with the spline on liner, spoke conduct
Power transmission part uniformly drives the rotation of spline platform from circumferential, and then drives liner rotation, the gap between internal portioning layer and outer jacket
Activity space as spoke.Agitating shaft is stirred emulsification to liposome for protruding into emulsion pot, and driving member will be for that will stir
The dynamic branch of axis passes to spoke, active magnet and is transmitted by moving magnet as the connection structure and power of driving member and spoke
Structure.Agitating shaft protrudes into rotation in emulsion pot and is stirred emulsification to liposome when use, while driving spoke by driving member
Rotation, spoke drive spline platform to circumferentially rotate, and spline platform drives liner to rotate by spline, the rotation direction and stirring of liner
The rotation direction of axis relatively rotates on the contrary, to exist between liner and agitating shaft, so that the agitation to liposome is more violent,
The emulsifying power of liposome is higher.
The advantages of this programme, is: 1, using the side of the emulsion pot liner and agitating shaft backwards rotation simultaneously that contain liposome
Formula, so that the liposome held in liner, by more violent, quick, high frequency impact, liposome can be emulsified faster
Molding；2, liner rotation is driven by the power of circumferential transmission simultaneously using internal shell with dissection, so that the operating of liner
It is more steady；3, liner is driven using the structure connection of magnetic absorption, liner can be lifted up in connection procedure, reduces liner
With the contact area of internal portioning layer, so that the rotation of liner is more smooth, in-house abrasion is smaller.
Further, blender includes end cap, and the top middle portion of end cap is equipped with motor, agitating shaft be located at end cap lower section and with electricity
The output axis connection of machine, cover internal are equipped with cavity, central gear are fixed on the agitating shaft in cavity, central gear
Outside is engaged with transmission gear, and transmission gear ring is engaged on the outside of transmission gear, and the shaft of transmission gear is fixed on the upper of cavity
Between lower wall, the bottom of end cap is equipped with annular through groove corresponding with transmission gear ring, and driving member is the bottom wall for being fixed on transmission gear ring
On multiple drive rods for being uniformly distributed circumferentially, the quantity of drive rod and the quantity of spoke are identical.As preferred end cap both conduct
The support construction of agitating shaft and motor is also used as the lid of emulsion pot, and motor is as power source, central gear, transmission gear, biography
The meshing relation and positional structure of movable tooth circle make the rotation direction for being driven gear ring and central gear on the contrary, transmission gear ring is as biography
The actuator and motion profile stopper of moving part, drive rod and spoke adsorb connection by active magnet, by moving magnet.In this way may be used
The shunting of motor output power is easily realized, and the power shunted is the opposite rotatory force of two rotation directions, convenient for simultaneously
Drive agitating shaft and liner reversely rotated.
Further, connecting cylinder includes that the inner sleeve being screwed with internal portioning layer top and outer jacket top are screwed
Outer sleeve.As the preferred cavity for forming annular between inner sleeve and outer sleeve in this way docking and turn convenient for spoke and drive rod
Dynamic, the dress that structure split type in this way is more convenient for dismounting progress liner takes, and can take out the liposome that liner obtains emulsification from bottom,
It is also convenient for dismounting, maintenance and the replacement of components.
Further, inner sleeve is threaded in the end cap bottom end on the inside of annular through groove, and it is logical that outer sleeve is threaded in annular
End cap bottom end on the outside of slot, inner sleeve top and bottom end thread rotary orientation are on the contrary, the thread rotary orientation of outer sleeve top and bottom end also phase
Instead.As the cavity for forming annular between preferred inner sleeve and outer sleeve passing through and circumferentially rotating convenient for drive rod, screw thread rotation
To setting generate opposite torsion between movement so that connecting cylinder top and the rotating dress of bottom end take, can avoid the disassembly of one end
The synchronous of the other end is caused to loosen.
Further, the side wall top surface inclination setting of liner, the inner wall of the high-end and internal portioning layer of top surface offset.As preferably this
Sample is arranged so that better tightness between the top and internal portioning layer of liner, can avoid liposome between the two to a certain degree
It is leaked in gap, such setting also helps the liposome scraping after the emulsification that will be attached on internal portioning layer and collects.
Further, the bottom end of agitating shaft is fixed with inclined axle sleeve, and the axis of axle sleeve intersects with the axis of agitating shaft, axle sleeve
Interior to be coaxially equipped with transmission shaft, the bottom end of transmission shaft is fixed with the stirring-head towards liner bottom wall and side wall intersection, transmission shaft
Top be fixed with driven wheel of differential, agitating shaft is equipped with the drive bevel gear engaged with driven wheel of differential.As preferably in this way
Agitating shaft drives the whole axis around agitating shaft of transmission shaft to rotate by axle sleeve, and drive bevel gear and driven wheel of differential drive and be driven
Axis rotation, and then more comprehensive agitation can be carried out to the liposome in liner by stirring-head, it especially can be to positioned at liner
The liposome of side wall and side wall and bottom wall intersection is effectively stirred, so that emulsifying effectiveness is more preferable, further increases emulsification effect
Rate.
Further, balance scraper plate is cased on transmission shaft, balance scraper plate and stirring-head are symmetricly set on left and right the two of agitating shaft
Side, balance side of the scraper plate far from agitating shaft are contacted with the internal portioning layer above liner.As preferred balance scraper plate one side conduct
The structure that stirring-head weight is balanced on agitating shaft, on the other hand as to the liposome being attached on internal portioning layer and inner sleeve inner wall
The structure scraped will be attached in internal portioning layer and inner sleeve during following axis rotation of the transmission shaft around agitating shaft
Liposome on wall scrapes to be continued to be stirred emulsification in the liner for being pushed through lower section, be further conducive to raising emulsifying effectiveness and
Emulsifying power.
Detailed description of the invention
Fig. 1 is the cross-sectional view of the embodiment of the present invention；
Fig. 2 be the embodiment of the present invention as shown in figure 1 A-A to cross-sectional view.
Specific embodiment
It is further described below by specific embodiment:
Appended drawing reference in Figure of description include: motor 1, central gear 2, end cap 3, agitating shaft 4, drive bevel gear 5,
Driven wheel of differential 6, casing 7, plate body 8, axle sleeve 9, transmission shaft 10, liner 11, internal portioning layer 12, spoke 13, outer jacket 14, spline platform
15, stirring-head 16, by moving magnet 17, annular gap 18, active magnet 19, drive rod 20, inner sleeve 21, outer sleeve 22, transmission
Gear ring 23, transmission gear 24.
Embodiment is basic as shown in attached drawing 1, Fig. 2: the emulsification mechanism of liposome, including emulsion pot and blender, emulsion pot
Including shell and liner 11, the exterior bottom of liner 11 is equipped with spline.Shell includes connecting cylinder and support base, and support base includes
Screw thread, the bottom of internal portioning layer 12 are equipped on the apical lateral wall of internal portioning layer 12 and outer jacket 14, internal portioning layer 12 and outer jacket 14
Equipped with through-hole corresponding with spline.Spline platform 15 is equipped between internal portioning layer 12 and outer jacket 14, the lower part of spline platform 15 is circumferential
Radial integrated molding there are six the identical spoke 13 of size of arc, spoke 13 be located at internal portioning layer 12 and outer jacket 14 it
Between, the top of each spoke 13 is embedded with by moving magnet 17.Connecting cylinder is detachably connected on the top of support base, connecting cylinder packet
The outer sleeve 22 for including the inner sleeve 21 being screwed with 12 top of internal portioning layer, being screwed with 14 top of outer jacket, inner sleeve 21
Vertically communicated annular gap 18 is formed between outer sleeve 22.
Blender is detachably connected on the top of connecting cylinder, and blender includes end cap 3, and the top middle portion of end cap 3 is equipped with electricity
Machine 1, the output shaft of motor 1 vertically pass through end cap 3 and are welded with agitating shaft 4.Cavity is equipped with inside end cap 3, in cavity
Key connection has central gear 2 on agitating shaft 4, and the outside of central gear 2 is engaged with transmission gear 24, and the outside of transmission gear 24 is nibbled
Conjunction has transmission gear ring 23, and transmission gear ring 23 is rotatably connected in cavity, and cavity sidewalls can be specifically processed as to cylindrical shape, cavity
Internal diameter with transmission the outer diameter of gear ring 23 it is identical so that transmission gear ring 23 by cavity sidewalls limit and guiding only can be in situ
Rotation.The shaft of transmission gear 24 is embedded between the upper and lower wall of cavity, and the cavity upper wall in 24 outside of transmission gear is downward
Connecting column is convexed to form, the bottom end of connecting column is equipped with back-off, and cavity bottom is equipped with the connecting hole through end cap, is buckled to across connection
Hole is buckled in the connection that the upper and lower wall of cavity is realized in end cap bottom end, and it is logical that the bottom of end cap 3 offers annular corresponding with transmission gear ring 23
Slot.The bottom end of blender is equipped with the driving member for protruding into annular gap 18, and driving member is connect with agitating shaft 4, and driving member is integrated into
Six drive rods 20 that type is uniformly distributed circumferentially on the bottom wall of transmission gear ring 23.By central gear 2, transmission gear 24,
It is driven gear ring 23 to connect driving member and the interval of agitating shaft 4, central gear 2, transmission gear 24 are driven power between gear ring 23
Transmitting so that the rotation direction of spoke 13 and the rotation direction of agitating shaft 4 on the contrary, driving member bottom end is also embedded with active magnet 19,
It is opposite with 19 bottom end polarity of active magnet by 17 top polarity of moving magnet.
Inner sleeve 21 is threaded in 3 bottom end of end cap on the inside of annular through groove, and outer sleeve 22 is threaded in annular through groove
3 bottom end of end cap in outside, 21 top of inner sleeve and bottom end thread rotary orientation on the contrary, outer sleeve 22 top and bottom end thread rotary orientation
On the contrary.The side wall top surface inclination of liner 11 is arranged, and the inner wall of the high-end and internal portioning layer 12 of top surface offsets.
The bottom end of agitating shaft 4 is welded with inclined axle sleeve 9, and the axis of the axis and agitating shaft 4 of axle sleeve 9 intersects at a point,
Coaxially it is equipped with transmission shaft 10 in axle sleeve 9, the bottom end of transmission shaft 10 is welded with stirring towards 11 bottom wall of liner and side wall intersection
Mix first 16, the top key connection of transmission shaft 10 has driven wheel of differential 6, and there is key connection on agitating shaft 4 engages with driven wheel of differential 6
Drive bevel gear 5.Balance scraper plate is cased on transmission shaft 10, balance scraper plate includes plate body 8 and casing 7, and casing 7 is set in transmission shaft
On 10, and the low side of casing 7 offsets with the high-end of axle sleeve 9, balance scraper plate and stirring-head 16 be symmetricly set on agitating shaft 4 a left side,
Right two sides, the plate body 8 for balancing scraper plate are contacted far from the side of agitating shaft 4 with the internal portioning layer 12 of 11 top of liner.
Specific implementation process is as follows: emulsion pot being placed on workbench or desktop when use, by end cap 3 from connecting cylinder
It removes, the liposome for needing to emulsify processing is imported in liner 11, at this time by moving magnet 17 and active magnet along screw thread rotation
There are spacing distance, spoke 13 and spline platforms 15 to fall on outer jacket 14 between 19, and liner 11 is fallen on internal portioning layer 12.Then again
End cap 3 is threadedly attached to connecting cylinder upper end, at this time active magnet 19 with by moving magnet 17 adsorb connect, by spoke 13,
Spline platform 15 is lifted up, and spline platform 15 is inserted into the spline on liner 11, and liner 11 is jacked up upwards by spline platform 15, liner
11 bottom is detached from internal portioning layer 12.It is powered to motor 1 and starts operating, motor 1 drives agitating shaft 4 to rotate, 9 driving transmission of stirring
Axis 10 is rotated around the axis of agitating shaft 4, while driving transmission shaft 10 certainly by the transmission of drive bevel gear 5, driven wheel of differential 6
Turn, transmission shaft 10 drives stirring-head 16 to carry out high-speed stirred to the liposome in liner 11 and is allowed to emulsify.2 band of central gear simultaneously
Nutating gear 24 rotates, and since the shaft of transmission gear 24 is embedded in cavity and transmission gear 24 is only capable of rotation, passes
Moving gear 24 drives transmission 23 rotation of gear ring, and the pivot center for being driven gear ring 23 is identical as central gear 2, and transmission gear ring 23 rotates
So that drive rod 20 follows rotation, drive rod 20 drives spoke 13 to rotate by active magnet 19 with by the absorption of moving magnet 17,
Six rotations of spoke 13 drive spline platform 15 to rotate from circumferential clocking of turbine, and spline platform 15 is connect in drive by the spline with spline
Gallbladder 11 rotate, the rotation direction of liner 11 rotated with transmission shaft 10 around agitating shaft 4 it is contrary, thus liposome at the same by
The stirring of the rotator inertia and stirring-head 16 of liner 11, so that liposome is by more high frequency, adequately impact stirring, so that rouge
The emulsifying effectiveness of plastid is more preferable, can reach the emulsification degree of needs faster, and emulsifying power is higher.Transmission shaft 10 is around agitating shaft
The plate body 8 of synchronous drive balance scraper plate follows rotation during 4 rotations, will splash during the rotation of plate body 8 for balancing scraper plate
Penetrate and be adhered to internal portioning layer 12, the liposome on inner sleeve 21 scrapes in liner 11 and whipping process is added so that liner 11 is added
Liposome adequately stirred, and be conducive to emulsification liposome fully enter in liner 11 convenient for all take out, reduce
Residual of the liposome in emulsion pot after emulsification.After emulsification by by outer jacket 14, internal portioning layer 12 from connecting cylinder
It removes, the whole taking-up from below of liner 11 can all be taken out convenient for the liposome after emulsifying.
Claims (7)
1. the emulsification mechanism of liposome, it is characterised in that: including emulsion pot and blender, emulsion pot includes shell and liner, interior
The exterior bottom of gallbladder is equipped with spline, and shell includes connecting cylinder and support base, and support base includes internal portioning layer and outer jacket, internal portioning layer
Be equipped with screw thread on the apical lateral wall of outer jacket, the bottom of internal portioning layer is equipped with through-hole corresponding with spline, internal portioning layer and
Spline platform, the circumferentially radial spoke integrally formed with multiple arcs in the lower part of spline platform, spoke bits are equipped between outer jacket
Between internal portioning layer and outer jacket, the top of each spoke is equipped with by moving magnet；Connecting cylinder is detachably connected on support base
Top, connecting cylinder side wall is interior to be equipped with vertically communicated annular gap, and blender is detachably connected on the top of connecting cylinder, blender
Including agitating shaft, the bottom end of blender is equipped with the driving member for protruding into annular gap, driving member and stirring axis connection, and driving member turns
The rotation direction of dynamic direction and agitating shaft is on the contrary, driving member bottom end also is provided with active magnet, by moving magnet bottom end polarity and actively
Magnet top polarity is opposite.
2. the emulsification mechanism of liposome according to claim 1, it is characterised in that: blender includes end cap, the top of end cap
End middle part is equipped with motor, and agitating shaft is located at below end cap and the output axis connection with motor, and cover internal is equipped with cavity, is located at sky
It is fixed with central gear on intracavitary agitating shaft, transmission gear, the outside engagement of transmission gear are engaged on the outside of central gear
There is transmission gear ring, the shaft of transmission gear is fixed between the upper lower wall of cavity, and the bottom of end cap is equipped with corresponding with transmission gear ring
Annular through groove, driving member is multiple drive rods for being uniformly distributed circumferentially on the bottom wall for be fixed on transmission gear ring, drive rod
Quantity is identical as the quantity of spoke.
3. the emulsification mechanism of liposome according to claim 2, it is characterised in that: the connecting cylinder includes and internal portioning layer top
The outer sleeve holding the inner sleeve being screwed, being screwed with outer jacket top.
4. the emulsification mechanism of liposome according to claim 3, it is characterised in that: inner sleeve is threaded in annular through groove
The end cap bottom end of inside, outer sleeve are threaded in the end cap bottom end on the outside of annular through groove, inner sleeve top and the rotation of bottom end screw thread
To on the contrary, the thread rotary orientation of outer sleeve top and bottom end is also opposite.
5. the emulsification mechanism of liposome according to claim 4, it is characterised in that: the side wall top surface inclination of the liner is set
It sets, the inner wall of the high-end and internal portioning layer of top surface offsets.
6. the emulsification mechanism of liposome according to claim 5, it is characterised in that: the bottom end of the agitating shaft, which is fixed with, inclines
Oblique axle sleeve, the axis of axle sleeve intersect with the axis of agitating shaft, and transmission shaft is coaxially equipped in axle sleeve, and the bottom end of transmission shaft is fixed
There is the stirring-head towards liner bottom wall and side wall intersection, the top of transmission shaft is fixed with driven wheel of differential, and agitating shaft is equipped with
The drive bevel gear engaged with driven wheel of differential.
7. the emulsification mechanism of liposome according to claim 6, it is characterised in that: be cased with balance scraper plate on transmission shaft, put down
Weighing apparatus scraper plate and stirring-head are symmetricly set on the arranged on left and right sides of agitating shaft, balance above side and liner of the scraper plate far from agitating shaft
Internal portioning layer contact.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811643682.2A CN109499405A (en) | 2018-12-29 | 2018-12-29 | The emulsification mechanism of liposome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811643682.2A CN109499405A (en) | 2018-12-29 | 2018-12-29 | The emulsification mechanism of liposome |
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| Publication Number | Publication Date |
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| CN109499405A true CN109499405A (en) | 2019-03-22 |
Family
ID=65755896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811643682.2A Pending CN109499405A (en) | 2018-12-29 | 2018-12-29 | The emulsification mechanism of liposome |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110102207A (en) * | 2019-04-29 | 2019-08-09 | 安庆市汇智科技咨询服务有限公司 | A kind of food inspection stirring homogeneous device |
| CN110292883A (en) * | 2019-07-18 | 2019-10-01 | 南京汇科高分子材料有限公司 | A kind of blender of laboratory foaming |
| CN110368838A (en) * | 2019-06-18 | 2019-10-25 | 湖南欣牧达畜牧设备有限公司 | A kind of poultry farming pellet mixing arrangement and its operating method |
| CN112889666A (en) * | 2021-03-25 | 2021-06-04 | 河北农业大学 | Artificial pollination tool for fruit trees |
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| CN107115813A (en) * | 2017-07-03 | 2017-09-01 | 王佳宝 | A kind of architectural decoration coating high-efficiency stirring equipment |
| CN207126458U (en) * | 2017-07-24 | 2018-03-23 | 曾国琼 | Surface coating dosing apparatus is used in a kind of fire hose production |
| CN108402429A (en) * | 2018-03-19 | 2018-08-17 | 务川县金锋猕猴桃种植农民专业合作社 | A kind of Kiwi berry pulping device |
| CN108619974A (en) * | 2018-03-31 | 2018-10-09 | 周戈 | A kind of medical treatment chlorination equipment |
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| DE3229146A1 (en) * | 1982-08-04 | 1984-02-09 | Leonhard Schmid Kg, 8900 Augsburg | Toothed rim holder for a mixing drum |
| FR2732238A1 (en) * | 1995-03-29 | 1996-10-04 | Bernard Lazareth Sa Ets | ROTARY TANK MIXER |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110102207A (en) * | 2019-04-29 | 2019-08-09 | 安庆市汇智科技咨询服务有限公司 | A kind of food inspection stirring homogeneous device |
| CN110368838A (en) * | 2019-06-18 | 2019-10-25 | 湖南欣牧达畜牧设备有限公司 | A kind of poultry farming pellet mixing arrangement and its operating method |
| CN110292883A (en) * | 2019-07-18 | 2019-10-01 | 南京汇科高分子材料有限公司 | A kind of blender of laboratory foaming |
| CN112889666A (en) * | 2021-03-25 | 2021-06-04 | 河北农业大学 | Artificial pollination tool for fruit trees |
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Application publication date: 20190322 |