CN109476654B - 新的荧光染料及其作为生物标志物的用途 - Google Patents

新的荧光染料及其作为生物标志物的用途 Download PDF

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CN109476654B
CN109476654B CN201780042127.1A CN201780042127A CN109476654B CN 109476654 B CN109476654 B CN 109476654B CN 201780042127 A CN201780042127 A CN 201780042127A CN 109476654 B CN109476654 B CN 109476654B
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CN109476654A (zh
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尼古拉·罗曼诺夫
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Illumina Cambridge Ltd
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves
    • C09B62/02—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring
    • C09B62/36—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves with the reactive group directly attached to a heterocyclic ring to some other heterocyclic ring
    • C09B62/365—Specific dyes not provided for in groups C09B62/38 - C09B62/42
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C09K2211/1025—Heterocyclic compounds characterised by ligands
    • C09K2211/1088—Heterocyclic compounds characterised by ligands containing oxygen as the only heteroatom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Saccharide Compounds (AREA)
CN201780042127.1A 2016-09-30 2017-09-29 新的荧光染料及其作为生物标志物的用途 Active CN109476654B (zh)

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Application Number Priority Date Filing Date Title
US201662402635P 2016-09-30 2016-09-30
US62/402,635 2016-09-30
PCT/EP2017/074880 WO2018060482A1 (en) 2016-09-30 2017-09-29 New fluorescent dyes and their uses as biomarkers

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CN109476654A CN109476654A (zh) 2019-03-15
CN109476654B true CN109476654B (zh) 2022-06-10

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EP (2) EP3974425B1 (enExample)
JP (2) JP7002478B2 (enExample)
KR (2) KR102582172B1 (enExample)
CN (1) CN109476654B (enExample)
AU (2) AU2017335223B2 (enExample)
CA (1) CA3026019C (enExample)
ES (2) ES2988726T3 (enExample)
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AU2017335223B2 (en) 2022-08-11
JP7002478B2 (ja) 2022-02-10
IL297749B1 (en) 2025-06-01
US20180094140A1 (en) 2018-04-05
WO2018060482A1 (en) 2018-04-05
CN109476654A (zh) 2019-03-15
EP3974425A1 (en) 2022-03-30
US20210071005A1 (en) 2021-03-11
CA3026019A1 (en) 2018-04-05
CA3026019C (en) 2022-05-17
KR102473054B1 (ko) 2022-11-30
IL263871B (en) 2022-12-01
JP2019531255A (ja) 2019-10-31
ES2914688T3 (es) 2022-06-15
US10385214B2 (en) 2019-08-20
US11370920B2 (en) 2022-06-28
US10844225B2 (en) 2020-11-24
NZ748812A (en) 2020-11-27
JP2022050495A (ja) 2022-03-30
KR102582172B1 (ko) 2023-09-22
IL297749A (en) 2022-12-01
KR20190057021A (ko) 2019-05-27
IL263871A (en) 2019-01-31
EP3519410A1 (en) 2019-08-07
EP3974425B1 (en) 2024-07-10
IL297749B2 (en) 2025-10-01
EP3519410B1 (en) 2022-03-30
ES2988726T3 (es) 2024-11-21
AU2017335223A1 (en) 2018-12-20
IL263871B2 (en) 2023-04-01
US20190367738A1 (en) 2019-12-05
SG11201810633WA (en) 2018-12-28
AU2022268273B2 (en) 2024-06-13
AU2022268273A1 (en) 2022-12-15
KR20220160714A (ko) 2022-12-06

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