CN109464296A - 一种含白藜芦醇三乙酸酯的修复乳 - Google Patents
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Abstract
本发明属日化领域,具体涉及一种含白藜芦醇三乙酸酯的修复乳。该修复乳除了包含有1.25%‑5.0%的乳化剂、18.05%‑27.2%的保湿润肤成份外,还含有0.5%‑1.5%的具有修复皮肤屏障功能的成份:神经酰胺1、胆甾醇以及亚油酸;另外,还特别添加白藜芦醇三乙酸酯,该化合物的加入,使本发明修复乳具有一定抑制酪氨酸酶的功效。
Description
技术领域
本发明属于日化领域,具体涉及一种含白藜芦醇三乙酸酯的修复乳。
背景技术
皮肤是人体最大的器官,在保护人体内环境稳定和阻止外界有害物质入侵方面发挥着极其重要的作用。角质层处于皮肤最外层,主要由角质细胞和角质基质(如神经酰胺、游离脂肪酸和胆固醇等)组成,角质细胞和脂质构成一道屏障,保护机体免受物理和化学的伤害。角质层的屏障功能主要是由脂质层决定的,其是化学物质扩散和水分渗透的主要通道,它的完整性是保证皮肤屏障功能稳定的结构基础。角质层的屏障功能异常可导致特应性皮炎、银屑病、鱼鳞病、干燥病等,屏障功能受损同时易使经皮水分流失量增加,因此修复皮肤受损的屏障功能具有重要意义。
本专利采用角质层脂质成分组合(神经酰胺、亚油酸和胆甾醇)作为修复成分,探讨其修复角质层屏障功能的效果。
白藜芦醇是广为所知的美白剂,有抑制酪氨酸酶活性的功效,但其稳定性不足,白藜芦醇三乙酸酯是白藜芦醇与三分子乙酸酯化的产物,具有更好稳定性,尚未见用于乳液中,本专利特别添加白藜芦醇三乙酸酯,并探讨其抑制酪氨酸酶活性的功效,使乳液具有修复功效的同时,获得额外其他功效。
发明内容
本发明的目的是提供一种含白藜芦醇三乙酸酯的修复乳。
本发明的目的是这样实现的:
一种含白藜芦醇三乙酸酯的修复乳,除含有乳液可接受的一般成份外,还含有:
占乳液重量1.25%-5.0%的乳化剂,该乳化剂为占乳液重量0.25%-1.0%的山梨坦倍半油酸酯和占乳液重量1.0%-4.0%的吐温-80的组合;
占乳液重量0.1%-0.5%的卡波姆;
占乳液重量18.05%-27.2%的保湿润肤成份,该成份为占乳液重量4.0%的甘油、占乳液重量2.0%的凡士林、占乳液重量3.0%-5.0%的辛酸/癸酸甘油三酯、占乳液重量3.0%-5.0%的环五聚二甲基硅氧烷、占乳液重量3.0%-6.0%的角鲨烷、占乳液重量2.0%-4.0%的碳酸二辛酯、占乳液重量0.05%-0.2%的透明质酸钠、占乳液重量1.0%的β-葡聚糖的组合;
占乳液重量0.1%-2.0%的白藜芦醇三乙酸酯,分子结构式如下:
占乳液重量0.5%-1.5%的具有修复皮肤屏障功能的生理脂质,该生理脂质为占乳液重量0.3%-0.9%的神经酰胺1、占乳液重量0.1%-0.3%的胆甾醇以及占乳液重量0.1%-0.3%的亚油酸的组合。
本发明的修复乳,其特征在于组份及其含量重量百分比分别为:
本发明的有益效果
本发明在配方中添加了多种人体皮肤角质层组成成分,包含神经酰胺、胆甾醇和亚油酸,测试表明该生理脂质的组合有助于修复皮肤的屏障功能,减少经皮水分流失;另外还添加了白藜芦醇三乙酸酯,该化合物的加入,使乳液具有一定的抑制酪氨酸酶活性的功效,具有潜在的美白效果。
附图说明
图1为志愿者使用样品不同时间后,皮肤失水率增加百分数。
图2为体外测试含不同重量百分比白藜芦醇三乙酸酯修复乳的酪氨酸酶活性抑制率。
具体实施方式
下面结合实施例对本发明作进一步详述。
先对本发明组份选取的特点、注意事项作详细介绍、说明。
本发明选取具有保湿润肤功效的基本原料,如凡士林、角鲨烷、小分子透明质酸钠等,凡士林在皮肤表面形成薄膜保湿,透明质酸钠分子量较低、皮肤亲和性较高,具有一定的渗透能力,角鲨烷、D5等原料协助保湿,同时使肤感不粘腻。另外选取人体皮肤角质层组成成分神经酰胺、胆甾醇和亚油酸等作为皮肤角质层修复成分,该组合对皮肤亲和力好,易渗透,有助于提高皮肤角质层缺失脂质,修复屏障功能。另外,为了获得额外功效,特别添加了具有抑制酪氨酸酶活性的白藜芦醇三乙酸酯,该化合物是白藜芦醇的酯化产物,相比于白藜芦醇,具有更好的稳定性,使乳液具有保湿、修复功效外,具备一定的抑制酪氨酸酶功效。
实施例I-V
以实施例I为例,其制作步骤如下:
1、把0.5gEDTA-2Na、10.0gβ-葡聚糖、40.0g甘油、2.0g卡波姆加入到778.0g去离子水中,加热到80℃,搅拌至溶解、分散充分;
2、将2.5g山梨坦倍半油酸酯、10.0g吐温-80、30.0g辛酸/癸酸甘油三酯、40.0g环五聚二甲基硅氧烷、30.0g角鲨烷、40.0g碳酸二辛酯、6.0g神经酰胺1、2.0g胆甾醇、3.0g亚油酸、2.0g羟苯甲酯和1.0g羟苯丙酯,在80℃下加热至熔融。
3、降温到45℃,先加入1.0g三乙醇胺,再加入0.5g透明质酸钠、1.0g白藜芦醇三乙酸酯、0.5g香精,搅拌均匀、降至室温后真空脱气。
本发明使用效果测试
招募12名年龄为25-35岁的志愿者,测试前于恒温恒湿条件下30min,手臂内侧画出4个区域,一个区域不涂抹样品(Ref),一个区域涂抹不含神经酰胺、亚油酸、胆甾醇的样品(base),一个区域涂抹含0.3%神经酰胺、0.1%胆甾醇、0.1%亚油酸的样品(0.3%Ce+0.1%Ch+0.1%Li),一个区域涂抹含0.9%神经酰胺、0.3%胆甾醇、0.3%亚油酸的样品(0.9%Ce+0.3%Ch+0.3%Li),涂抹样品前用Tewameter TM300测试数值,平行测三次取平均。涂抹样品量为30mg/cm2,涂抹样品后,于1h、2h、3h后分别测试数值,(施用样品后测试数值-施用样品前测试数值)/施用样品前测试数值×100%,记为失水率增加百分数。从图1可以看出,含神经酰胺、亚油酸、胆甾醇的样品能显著减少经皮水分流失,含0.9%Ce+0.3%Ch+0.3%Li的样品,比含0.3%Ce+0.1%Ch+0.1%Li的样品效果更佳,经皮水分流失这个参数可以用来衡量皮肤角质层的屏障功能,测试表明含神经酰胺、亚油酸、胆甾醇的乳液具有一定修复皮肤屏障的功效。
另外,研究了含不同重量百分比白藜芦醇三乙酸酯的修复乳抑制酪氨酸酶活性的功效(见图2)。测试表明,随着白藜芦醇三乙酸酯重量百分比的增加,修复乳抑制酪氨酸酶活性的功效越强,说明具有潜在的美白效果。
Claims (3)
1.一种含白藜芦醇三乙酸酯的修复乳,除含有乳液可接受的一般成份外,还含有:
占乳液重量1.25%-5.0%的乳化剂,该乳化剂为占乳液重量0.25%-1.0%的山梨坦倍半油酸酯和占乳液重量1.0%-4.0%的吐温-80的组合;
占乳液重量0.1%-0.5%的卡波姆;
占乳液重量18.05%-27.2%的保湿润肤成份,该成份为占乳液重量4.0%的甘油、占乳液重量2.0%的凡士林、占乳液重量3.0%-5.0%的辛酸/癸酸甘油三酯、占乳液重量3.0%-5.0%的环五聚二甲基硅氧烷、占乳液重量3.0%-6.0%的角鲨烷、占乳液重量2.0%-4.0%的碳酸二辛酯、占乳液重量0.05%-0.2%的透明质酸钠以及占乳液重量1.0%的β-葡聚糖的组合;
占乳液重量0.1%-2.0%的白藜芦醇三乙酸酯,分子结构式如下:
。
2.根据权利要求1所述的修复乳,还包含有占乳液重量0.5%-1.5%的具有修复皮肤屏障功能的成份,该成份为占乳液重量0.3%-0.9%的神经酰胺1、占乳液重量0.1%-0.3%的胆甾醇以及占乳液重量0.1%-0.3%的亚油酸的组合。
3.一种含白藜芦醇三乙酸酯的修复乳,其特征在于其组份及其含量重量百分比分别为:
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CN111135107A (zh) * | 2020-01-09 | 2020-05-12 | 广州市科能化妆品科研有限公司 | 一种修复皮肤屏障组合物及其制备方法 |
CN113304134A (zh) * | 2020-06-30 | 2021-08-27 | 成都医学院 | N-亚油酰酪氨酸在制备具有神经保护作用的药物中的用途 |
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CN104994831A (zh) * | 2013-01-22 | 2015-10-21 | 国立庆北大学校产学协力团 | 白藜芦醇衍生物的皮肤美白用途 |
CN106309340A (zh) * | 2016-11-11 | 2017-01-11 | 广西大学 | 一种柚子汁抗皱去纹护肤配方 |
WO2017155875A1 (en) * | 2016-03-07 | 2017-09-14 | Elc Management Llc | Resveratrol glycolate and tartrate derivatives and synthetic methods therefor |
CN107320374A (zh) * | 2017-07-12 | 2017-11-07 | 拉芳家化股份有限公司 | 一种含姜黄素类似物的护肤乳 |
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Patent Citations (4)
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CN104994831A (zh) * | 2013-01-22 | 2015-10-21 | 国立庆北大学校产学协力团 | 白藜芦醇衍生物的皮肤美白用途 |
WO2017155875A1 (en) * | 2016-03-07 | 2017-09-14 | Elc Management Llc | Resveratrol glycolate and tartrate derivatives and synthetic methods therefor |
CN106309340A (zh) * | 2016-11-11 | 2017-01-11 | 广西大学 | 一种柚子汁抗皱去纹护肤配方 |
CN107320374A (zh) * | 2017-07-12 | 2017-11-07 | 拉芳家化股份有限公司 | 一种含姜黄素类似物的护肤乳 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111135107A (zh) * | 2020-01-09 | 2020-05-12 | 广州市科能化妆品科研有限公司 | 一种修复皮肤屏障组合物及其制备方法 |
CN113304134A (zh) * | 2020-06-30 | 2021-08-27 | 成都医学院 | N-亚油酰酪氨酸在制备具有神经保护作用的药物中的用途 |
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