CN109498493A - 一种含白藜芦醇三乙醇酸酯的乳液 - Google Patents

一种含白藜芦醇三乙醇酸酯的乳液 Download PDF

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CN109498493A
CN109498493A CN201811571416.3A CN201811571416A CN109498493A CN 109498493 A CN109498493 A CN 109498493A CN 201811571416 A CN201811571416 A CN 201811571416A CN 109498493 A CN109498493 A CN 109498493A
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lotion
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skin
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林学镁
陈贤鹰
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LAF INTERNATIONAL GROUP Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

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Abstract

本发明属日化领域，具体涉及一种含白藜芦醇三乙醇酸酯的乳液。该乳液除了包含有1.25％‑5.0％的乳化剂、18.05％‑27.2％的保湿润肤成份外，还含有0.5％‑1.5％的具有修复皮肤屏障功能的成份：神经酰胺1、胆甾醇以及亚油酸；另外，还特别添加0.1％‑2.0％白藜芦醇三乙醇酸酯。本发明包含神经酰胺、胆甾醇和亚油酸，另外还添加了白藜芦醇三乙醇酸酯，具有一定的淡肤功效。

Description

一种含白藜芦醇三乙醇酸酯的乳液
技术领域
本发明属于日化领域，具体涉及一种含白藜芦醇三乙醇酸酯的乳液。
背景技术
皮肤是人体最大的器官，在保护人体内环境稳定和阻止外界有害物质入侵方面发挥着极其重要的作用。角质层处于皮肤最外层，主要由角质细胞和角质基质(如神经酰胺、游离脂肪酸和胆固醇等)组成，角质细胞和脂质构成一道屏障，保护机体免受物理和化学的伤害。角质层的屏障功能主要是由脂质层决定的，其是化学物质扩散和水分渗透的主要通道，它的完整性是保证皮肤屏障功能稳定的结构基础。角质层的屏障功能异常可导致特应性皮炎、银屑病、鱼鳞病、干燥病等，屏障功能受损同时易使经皮水分流失量增加，因此修复皮肤受损的屏障功能具有重要意义。
本专利添加角质层脂质成分组合(神经酰胺、亚油酸和胆甾醇)作为修复成分，对皮肤具有良好亲和性。
另外，白藜芦醇是广为所知的美白剂，有抑制酪氨酸酶活性的功效，但其稳定性不足，白藜芦醇三乙醇酸酯是白藜芦醇与三分子乙醇酸酯化的产物，具有更好稳定性，尚未见用于乳液中，本专利特别添加白藜芦醇三乙醇酸酯，并招募志愿者评估其淡肤功效。
发明内容
本发明的目的是提供一种含白藜芦醇三乙醇酸酯的乳液。
本发明的目的是这样实现的：
一种含白藜芦醇三乙醇酸酯的乳液，除含有乳液可接受的一般成份外，还含有：
占乳液重量1.25％-5.0％的乳化剂，该乳化剂为占乳液重量0.25％-1.0％的山梨坦倍半油酸酯和占乳液重量1.0％-4.0％的吐温-80的组合；
占乳液重量0.1％-0.5％的卡波姆；
占乳液重量18.05％-27.2％的保湿润肤成份，该成份为占乳液重量4.0％的甘油、占乳液重量2.0％的凡士林、占乳液重量3.0％-5.0％的辛酸/癸酸甘油三酯、占乳液重量3.0％-5.0％的环五聚二甲基硅氧烷、占乳液重量3.0％-6.0％的角鲨烷、占乳液重量2.0％-4.0％的碳酸二辛酯、占乳液重量0.05％-0.2％的透明质酸钠、占乳液重量1.0％的β-葡聚糖的组合；
占乳液重量0.5％-1.5％的具有修复皮肤屏障功能的生理脂质，该生理脂质为占乳液重量0.3％-0.9％的神经酰胺1、占乳液重量0.1％-0.3％的胆甾醇以及占乳液重量0.1％-0.3％的亚油酸的组合；
占乳液重量0.1％-2.0％的白藜芦醇三乙醇酸酯
本发明的有益效果
本发明在配方中添加了多种人体皮肤角质层组成成分，包含神经酰胺、胆甾醇和亚油酸，另外还添加了白藜芦醇三乙醇酸酯，经过评估，实施例具有一定的淡肤功效。
具体实施方式
下面结合实施例对本发明作进一步详述。
先对本发明组份选取的特点、注意事项作详细介绍、说明。
本发明选取具有保湿润肤功效的基本原料，如凡士林、角鲨烷、小分子透明质酸钠等，凡士林在皮肤表面形成薄膜保湿，透明质酸钠分子量较低、皮肤亲和性较高，具有一定的渗透能力，角鲨烷、D5等原料协助保湿，同时使肤感不粘腻。另外选取人体皮肤角质层组成成分神经酰胺、胆甾醇和亚油酸等作为皮肤角质层修复成分，该组合对皮肤亲和力好，易渗透，有助于提高皮肤角质层缺失脂质，修复屏障功能。另外，为了获得额外功效，特别添加了白藜芦醇三乙醇酸酯，该化合物是白藜芦醇的酯化产物，相比于白藜芦醇，具有更好的稳定性，使乳液具有保湿、修复功效外，具备一定的淡肤效果。
实施例I－V
效果调查：
招募15名女性志愿者(年龄为25-35岁)，告知测试目的后，签署知情协议书。左、右脸分别应用含2.0％RTG的样品、不含RTG的乳液样品，志愿者不知晓样品信息。志愿者使用统一分发的洁面产品，涂抹乳液前使用，早晚各应用一次，应用周期30天，期间要求生活作息规律。30天后，由评估人员通过对比左右脸肤色差异对淡肤效果进行评估，统计如下。
淡肤效果明显 轻微淡肤 无差异
人数 7 4 1

Claims (1)

1.一种乳液，除含有乳液可接受的一般成份外，还含有：
占乳液重量1.25％-5.0％的乳化剂，该乳化剂为占乳液重量0.25％-1.0％的山梨坦倍半油酸酯和占乳液重量1.0％-4.0％的吐温-80的组合；
占乳液重量0.1％-0.5％的卡波姆；
占乳液重量18.05％-27.2％的保湿润肤成份，该成份为占乳液重量4.0％的甘油、占乳液重量2.0％的凡士林、占乳液重量3.0％-5.0％的辛酸/癸酸甘油三酯、占乳液重量3.0％-5.0％的环五聚二甲基硅氧烷、占乳液重量3.0％-6.0％的角鲨烷、占乳液重量2.0％-4.0％的碳酸二辛酯、占乳液重量0.05％-0.2％的透明质酸钠以及占乳液重量1.0％的β-葡聚糖的组合；
占乳液重量0.5％-1.5％的具有修复皮肤屏障功能的成份，该成份为占乳液重量0.3％-0.9％的神经酰胺1、占乳液重量0.1％-0.3％的胆甾醇以及占乳液重量0.1％-0.3％的亚油酸的组合；
占乳液重量0.1％-2.0％的白藜芦醇三乙醇酸酯，分子结构式如下：
CN201811571416.3A 2018-12-21 2018-12-21 一种含白藜芦醇三乙醇酸酯的乳液 Withdrawn CN109498493A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116034099A (zh) * 2020-06-11 2023-04-28 Elc 管理有限责任公司 白藜芦醇乙醇酸酯和酒石酸酯衍生物的增溶

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101854903A (zh) * 2007-09-08 2010-10-06 Elc管理有限责任公司 阿魏酸白藜芦醇酯化合物、包含该化合物的组合物及其使用方法
CN106309340A (zh) * 2016-11-11 2017-01-11 广西大学 一种柚子汁抗皱去纹护肤配方
WO2017155875A1 (en) * 2016-03-07 2017-09-14 Elc Management Llc Resveratrol glycolate and tartrate derivatives and synthetic methods therefor
CN107320374A (zh) * 2017-07-12 2017-11-07 拉芳家化股份有限公司 一种含姜黄素类似物的护肤乳
CN108524399A (zh) * 2018-07-02 2018-09-14 上海新高姿化妆品有限公司 一种具有长效保湿功效的乳液及其制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101854903A (zh) * 2007-09-08 2010-10-06 Elc管理有限责任公司 阿魏酸白藜芦醇酯化合物、包含该化合物的组合物及其使用方法
WO2017155875A1 (en) * 2016-03-07 2017-09-14 Elc Management Llc Resveratrol glycolate and tartrate derivatives and synthetic methods therefor
CN106309340A (zh) * 2016-11-11 2017-01-11 广西大学 一种柚子汁抗皱去纹护肤配方
CN107320374A (zh) * 2017-07-12 2017-11-07 拉芳家化股份有限公司 一种含姜黄素类似物的护肤乳
CN108524399A (zh) * 2018-07-02 2018-09-14 上海新高姿化妆品有限公司 一种具有长效保湿功效的乳液及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116034099A (zh) * 2020-06-11 2023-04-28 Elc 管理有限责任公司 白藜芦醇乙醇酸酯和酒石酸酯衍生物的增溶

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Application publication date: 20190322