CN109453227A - 一种原花青素和中药提取物的组合物和用途 - Google Patents
一种原花青素和中药提取物的组合物和用途 Download PDFInfo
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- CN109453227A CN109453227A CN201811342116.8A CN201811342116A CN109453227A CN 109453227 A CN109453227 A CN 109453227A CN 201811342116 A CN201811342116 A CN 201811342116A CN 109453227 A CN109453227 A CN 109453227A
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Abstract
本发明属于保健品加工领域,本发明提供一种药用组合物,它是由原花青素和中药提取物按重量百分比为原花青素2.5‑5%,中药提取物95‑97.5%组成,其制备方法:取配比重量较小的原花青素按等量递加方法依次逐步递加加入中药提取物,充分研磨至均匀,过筛即得。本发明利用原花青素具有抗氧化、清除自由基的有益效果,与具有益气化瘀,调经祛斑,滋养肌肤作用的中药组合,对防治自由基对肌肤的损伤,促进血液循环,增进肌肤细胞发育具有较好的辅助防治效果。所述组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
Description
技术领域
本发明涉及药物制剂和/或保健食品加工领域,具体涉及一种由原花青素和中药提取物组成的药物组合物和用途。
背景技术
原花青素(Procyanidins)是自然界中广泛存在的聚多酚类混合物,主要由儿茶素的单体、二聚体、三聚体、……、十聚体等组合而成。低聚原花青素(OligomericProcyanidins,OPC´s),以其高效、低毒、高生物利用率著称。OPC´s拥有强有力的抗氧化能力,在体内其抗氧化、清除自由基的能力是维生素E的50倍,维生素C的20倍,并吸收迅速完全,口服20mg即可得到最高血浓度,代谢半衰期约为7h。国外关于OPC´s性能的研究很多,并广泛将其用于食品、饮料、化妆品及保健品领域。1995年末,美国Whole Foods杂志举行了由公众自由投票选举自己信赖的植物药的民意测验,在未设候选药物的情况下,89.9%的选票集中在10种植物药名下,其中原花青素被认为是最受美国公众青睐并风靡美国草药市场的植物药。
原花青素(Procyanidins,PC),是植物王国中广泛存在的一大类多酚化合物的总称。起初统归于缩合鞣质或黄烷醇类,随着分离鉴定技术的提高和对此类物质研究和认识的深入,现已将该类物质列为相对独立的一大类物质并称之为原花青素。
原花青素生理功能表现为:(1)抗氧化剂功能,(2)抗癌功能,(3)清除自由基,多酚类化合物清除自由基的活性主要是由于他们提供氢原子的缘故,另外苯环上π键的离域效应对多酚类化合物清除自由基的功能也有重要贡献。Sarma等考察了花色素苷保护DNA不受羟基自由基破坏的作用,发现花色素苷可以和DNA结合形成络合物,既能保护DNA又能保护自身不受自由基的破坏。(4)原花青素在药品与化妆品等领域中的应用,葡萄籽原花青素的血管活性、抗弹性酶活性及抗氧化活性使其在药品和化妆品等领域中得到广泛应用。
①药物 葡萄籽原花青素对血管疾病的治疗价值在20世纪80年代初即已被世人所承认。在法国,用葡萄籽原花青素制成的专利产品用于治疗微循环疾病,包括眼睛与外周毛细血管通透性疾病及静脉与淋巴功能不全;法国Bonnaure等发明以原花青素低聚体或单体为活性成分(含量0.1%)来治疗牙周病制剂并已获专利;法国Sanofi公司用葡萄籽原花青素与大豆卵磷脂制成复合物(每片含此复合物250mg),用作血管保护剂和抗炎剂;法国Vennat等还制成含80%原花青素的高剂量片(50mg/片),该片剂能迅速而完全释放,而且在不同条件下,储存10个月仍有很好的稳定性;德国的Berkhman等研制了用于治疗酒精中毒的原花青素制剂等。
②化妆品 1990年法国Masquelier对原花青素在适应证中的治疗作用如抗炎、抗辐射等活性进行了研究。结果表明,原花青素的治疗作用与其清除自由基的能力密切相关,而环境对皮肤、黏膜和毛发的刺激引起的脂质、蛋白质与核酸的衰退过程均与自由基需不可分。原花青素所具有的强力抗氧活性和清除自由基的能力是其作为生物活性成分在化妆品中使用的内在基础。
③在食品中的应用 由于OPC´s来源于食物性原料且生产过程基本未引入有害物质,因再其安全性毋庸置疑,在食品中作为抗氧化剂来使用没有任何问题。目前其在食品中主要是作为天然抗氧化剂、保健食品原料及营养强化食品的强化剂来使用(张连富 吉宏武主编,《药食兼用资源与生物活性成分》,化学工业出版社,2005年9月第1版,189-191页)。
由于现代人们生活节奏加快,生活压力大,生活结构的变化,加之环境污染给现代生活中一些特有的疾病也相应的呈现增多趋势。如因气血不足,气血阻滞或气虚血瘀等所致的内分泌紊乱,黄褐斑(黧黑斑)、雀斑、蝴蝶斑,皮肤面黄粗糙等病例明显增加,直到目前也未有确切疗效的治疗药物。利用原花青素具有特殊的抗氧化和清除自由基作用的功效,结合我国传统的中医药理论,与具有益气化瘀,调经祛斑,滋养肌肤的中药组合,将原花青素这种天然活性物质与传统医学和现代制药工艺技术有机结合,组成一种新的药物组合物,使该组合物能在上述疾病的治疗中起到辅助的防治作用。
发明内容
本发明的目的在于提供一种由原花青素和一种中药提取物组成的药用组合物和用途。
本发明的目的还在于提供一种药用组合物在制备辅助调节益气化瘀、调经祛斑、滋养肌肤药物中作为制备保健品的用途。
本发明的目的还在于提供一种药物组合物在制备化妆品中的添加剂的用途。
本发明提供的一种药物组合物,其特征在于,它是由原花青素和中药提取物按重量百分比为原花青素2.5-5%,中药提取物95-97.5%组成,所述的中药提取物按以下方法制备:将人参150g,当归450g,川穹100g,黄芪550g加入浓度为75%(v/v)的乙醇12500g在38-42℃下浸泡168小时,滤取浸泡提取液,回收乙醇得浸提液保存备用,另将药渣分别按药材重量8倍、5倍、3倍加水煎煮3次,煎煮时间为第1次2小时,第二次1小时,第三次0.5小时,合并3次煎煮液,经过滤,经浓缩至比重为1.0的浓缩液时,再与上述回收乙醇后的浸提液合并,再进一步浓缩成稠膏,干燥至含水量小于5%w/w的浸膏。
该中药浸膏在下文中称作“本文(或上文)所述的中药提取物”。
本发明组合物的配制方法,可取配比重量较小的原花青素按等量递加方法依次逐步递加加入中药提取物,充分研磨至均匀,过筛即得。
上述所述的干燥采用本领域公知的干燥技术条件下的干燥手段,如真空干燥、冷冻干燥或热风低温干燥等,在考虑到避免或减少中药提取物中有效成分的流失的条件,选择避免高温的干燥方法均适用于本发明中的干燥处理。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液作为制备保健品的用途。
所述的药物组合物作为制备酒制品的用途。
所述的药物组合物作为制备化妆品中的添加剂的用途。
人参,甘,微苦,微温。归脾、肺、心肾经。具有大补元气,复脉固脱,补脾益肺,生津养血、安神益智功能。人参大补元气,元气充则心气得养,心神得宁,心智得聪,而具安神益智的功效,用于治疗心气不足或心肾气虚、心脾两虚的失眠、健忘等。人参甘温,大补元气,益气以生血,具气血双补之效,故可用治脾胃气虚,化源不足,血虚萎黄之证。
当归,甘、辛,温。归肝、心、脾经。具有补血活血,调经止痛,润肠通便功能,用于血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,风湿痹痛,跌扑损伤,痈疽疮疡,肠燥便秘。当归甘温,养血补虚,为补血良药,故可用治心肝血虚,血色萎黄,眩晕心悸。
川穹,辛,温。归肝、胆、心包经。具有活血行气,祛风止痛功能。川穹辛散温通,功能活血行气,有“血中气药”(《本草汇言》)之称。既活血祛瘀通脉,善治心脉瘀阻、胸痹心痛;又行气开郁止痛,为肝郁气滞之胸肋刺痛所多用。川穹善于“下调经水”(《本草汇言》)、活血调经,优为月经不调、痛经、经闭等证之要药;亦治癥瘕腹痛,具有活血祛瘀、消癥散结之功。
黄芪,甘,微温。归肺、脾经。具有补气升阳,固表止汗,利水消肿,生津养血,行滞通痹,托毒排脓,敛疮生肌功效,用于气血乏力,食少便溏,中气下陷,腹泻脱肛,便血崩漏,表虚自汗,气虚水肿,内热消渴,气虚萎黄之证。黄芪甘微温,益气升阳,盖阳生阴长,气旺血生,故有补气生血之功,长用于劳倦内伤,气亏血虚,血虚阳浮,肌热面赤,脉大无力之血虚发热证。及思虑过度,劳伤心脾,气血双亏,面色萎黄,心悸失眠者。
以上4种中药组成制备提取物,按照中医药理论证明具有益气化瘀,调经祛斑,滋养肌肤作用,按现代中药理论研究,如组份中当归为主药之一,其有效成分阿魏酸能减少H2O2含量,并与磷脂酰乙醇胺结合抑制氧化反应和自由基反应,拮抗自由基对组织的损害,促进血液循环,增进肌肤细胞发育的作用。阿魏酸不仅能淬灭自由基。而且还能调节人体生理机制,抑制产生自由基的酶,促进清除自由基的酶的产生。
利用原花青素活性成分与中药组合提取物能产生不同成分、不同作用机制的协同治疗作用,能强化其药物的抗氧化和清除自由基作用。本发明利用原花青素具有抗氧化、清除自由基的有益效果,与具有益气化瘀,调经祛斑,滋养肌肤作用的中药组合,对防治自由基对肌肤的损伤,促进血液循环,增进肌肤细胞发育具有较好的辅助防治效果。通过原花青素与本发明中药组合的提取物,组成新的药用组合物,能够充分发挥原花青素和中药成分有益效果,特别是增加了原花青素具有的特殊抗氧化和清除自由基的功效,强化了药物对皮肤损伤、斑、癣疾病及皮肤色素沉着等具有良好的调理功能,为本发明药物组合物在保健食品、化妆品中的应用提供了理论基础。尤其是抗氧化、清除自由基和身体机能调理功能更为显著,因此产品既可以作为保健食品内服食用或饮用,也可作为天然的美容护肤产品外用。本发明克服了目前中药组合成分功效不理想的问题,而且产品使用方便,口感较好,工艺简单,生产效率高,质量稳定,可广泛用于保健品、酒品、化妆品的生产。
本发明的一种药用组合物,可以根据需要配制成不同的口服剂型。可以将药用组合物与药学上可接受的辅料混合配制成片剂,胶囊剂,颗粒剂,酒制品等,其中胶囊剂可制备成软胶囊剂和硬胶囊剂;其中片剂优选泡腾片,咀嚼片,口含片,因为泡腾片,咀嚼片,口含片与普通片剂相比有以下几点优势:(1)服用方便,可嚼服、含服,可化水,由于配制这些片剂都要加入一定量的糖份作为赋形剂,因而口感好,人们乐意服用,泡腾片加水自溶后犹如一杯饮料,使人们乐于饮用;(2)吸收快,因为经口腔或泡饮使药物成分离子化,使之吸收快,生物利用度高;(3)便于携带,方便运输;其中所述的酒品可制成白酒、葡萄酒、黄酒和啤酒制品。本发明一种药用组合物,还可以根据需要配制成化妆品。
具体实施方式
通过以下实施例是对本发明作进一步的说明,但对本发明的范围不构成任何限制。
实施例1
中药提取物的制备
分别称取净药材人参150g,当归450g,川穹100g,黄芪550g,置于提取罐中,加入浓度为75%的乙醇12.5kg,在40℃条件下密闭浸泡168小时,浸泡期间每隔6小时进行搅拌1次,浸泡结束后,滤取浸泡提取液,将浸泡提取液回收乙醇得浸提液另器保存备用;将醇浸提后的药渣加入纯净水10公斤,加热煎煮2小时,滤取煎煮液,药渣再加入纯净水6.25公斤,加热煎煮1小时,滤取煎煮液,再将药渣加纯净水3.75公斤,加热煎煮0.5小时,滤取煎煮液,将3次煎煮液合并,过滤,将滤液浓缩至比重为1.0的浓缩液时,再与上述浸提液合并,再进一步浓缩成稠膏后,置于真空干燥机内进行真空干燥至含水量为4.5%,即得中药提取物。
实施例2
中药提取物的制备
分别称取净药材人参150g,当归450g,川穹100g,黄芪550g,置于提取罐中,加入浓度为75%的乙醇12.5kg,在38℃条件下密闭浸泡168小时,浸泡期间每隔6小时进行搅拌1次,浸泡结束后,滤取浸泡提取液,将浸泡提取液回收乙醇得浸提液另器保存备用;将醇浸提后的药渣加入纯净水10公斤,加热煎煮2小时,滤取煎煮液,药渣再加入纯净水6.25公斤,加热煎煮1小时,滤取煎煮液,再将药渣加纯净水3.75公斤,加热煎煮0.5小时,滤取煎煮液,将3次煎煮液合并,过滤,将滤液浓缩至比重为1.0的浓缩液时,再与上述浸提液合并,再进一步浓缩成稠膏后,置于真空干燥机内进行真空干燥至含水量为4.8%,即得中药提取物。
实施例3
中药提取物的制备
分别称取净药材人参150g,当归450g,川穹100g,黄芪550g,置于提取罐中,加入浓度为75%的乙醇12.5kg,在42℃条件下密闭浸泡168小时,浸泡期间每隔6小时进行搅拌1次,浸泡结束后,滤取浸泡提取液,将浸泡提取液回收乙醇得浸提液另器保存备用;将醇浸提后的药渣加入纯净水10公斤,加热煎煮2小时,滤取煎煮液,药渣再加入纯净水6.25公斤,加热煎煮1小时,滤取煎煮液,再将药渣加纯净水3.75公斤,加热煎煮0.5小时,滤取煎煮液,将3次煎煮液合并,过滤,将滤液浓缩至比重为1.0的浓缩液时,再与上述浸提液合并,再进一步浓缩成稠膏后,置于真空干燥机内进行真空干燥至含水量为4.0%,即得中药提取物。
实施例4
药物组合物的制备
称取原花青素25g,置乳钵中,按等量递加方法加入实施例1制得的中药提取物25g,研磨至均匀,再等量递加中提取物50g,研磨均匀,按依次等量递加中药提取物至全量1000g,充分研磨均匀,过筛,即得。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
实施例5
药物组合物的制备
称取原花青素50g,置乳钵中,按等量递加方法加入实施例1制得的中药提取物50g,研磨至均匀,再等量递加中提取物100g,研磨均匀,按依次等量递加中药提取物至全量1000g,充分研磨均匀,过筛,即得。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
实施例6
药物组合物的制备
称取原花青素30g,置乳钵中,按等量递加方法加入实施例2制得的中药提取物30g,研磨至均匀,再等量递加中提取物60g,研磨均匀,按依次等量递加中药提取物至全量1000g,充分研磨均匀,过筛,即得。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
实施例7
药物组合物的制备
称取原花青素40g,置乳钵中,按等量递加方法加入实施例2制得的中药提取物40g,研磨至均匀,再等量递加中提取物80g,研磨均匀,按依次等量递加中药提取物至全量1000g,充分研磨均匀,过筛,即得。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
实施例8
药物组合物的制备
称取原花青素35g,置乳钵中,按等量递加方法加入实施例3制得的中药提取物35g,研磨至均匀,再等量递加中提取物70g,研磨均匀,按依次等量递加中药提取物至全量1000g,充分研磨均匀,过筛,即得。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
实施例9
药物组合物的制备
称取原花青素45g,置乳钵中,按等量递加方法加入实施例3制得的中药提取物45g,研磨至均匀,再等量递加中提取物90g,研磨均匀,按依次等量递加中药提取物至全量1000g,充分研磨均匀,过筛,即得。
所述的药物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途或作为制备化妆品中的添加剂的用途。
实施例10
可按常规方式生产含有下列组份的酒:
组份:
称取实施例7药物组合物 30g
50度白酒 970g
取药物组合物加入50度白酒中,充分搅拌,然后放置室温处,密闭贮存21天后,过滤,即得。
实施例11
可按常规方式生产含有下列组份的酒:
组份:
称取实施例6药物组合物 50g
蜂蜜 120g
柠檬酸 11g
22度白酒 加至 1000g
取药物组合物、柠檬酸和蜂蜜分别依次加入适量的22度白酒中使溶,然后加入余量的白酒,搅拌均匀,置于室温暗处,静置1周后,经过滤,分装,密封即得。
实施例12
可按常规方式生产含有下列组份的酒:
组份:
称取实施例4药物组合物 25g
黄酒 加至 1000g
取药物组合物加入适量黄酒中使溶,然后加入余量的黄酒,搅拌均匀,置于3-5℃环境下,静置24小时,过滤,装瓶,封口即得。
Claims (5)
1.一种原花青素中药提取物,其特征在于,它是由原花青素和中药提取物按重量百分比为原花青素2.5-5%,中药提取物95-97.5%组成,
其制备方法:取配比重量较小的原花青素按等量递加方法依次逐步递加加入中药提取物,充分研磨至均匀,过筛即得;其中所述的中药提取物按以下方法制备:将人参150g,当归450g,川穹100g,黄芪550g加入浓度为75%v/v的乙醇12500g在38-42℃下浸泡168小时,滤取浸泡提取液,回收乙醇得浸提液保存备用,另将药渣分别按药材重量8倍、5倍、3倍加水煎煮3次,煎煮时间为第1次2小时,第二次1小时,第三次0.5小时,合并3次煎煮液,经过滤,经浓缩至比重为1.0的浓缩液时,再与上述回收乙醇后的浸提液合并,再进一步浓缩成稠膏,干燥至含水量小于5%w/w的浸膏。
2.如权利要求1所述原花青素中药提取物组合物按常规工艺制成片剂、胶囊剂、颗粒剂、口服液或酒品作为制备保健品的用途。
3.如权利要求1所述的原花青素中药提取物组合物作为制备化妆品中的添加剂的用途。
4.根据权利要求2所述的原花青素中药提取物组合物的用途,用于配制泡腾片,咀嚼片,口含片。
5.根据权利要求2所述的原花青素中药提取物组合物的用途,用于配制白酒、葡萄酒、黄酒和啤酒。
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