CN109453071A - A kind of rosemary bacteriostatic hand sanitizer and preparation method thereof - Google Patents
A kind of rosemary bacteriostatic hand sanitizer and preparation method thereof Download PDFInfo
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- CN109453071A CN109453071A CN201811493122.3A CN201811493122A CN109453071A CN 109453071 A CN109453071 A CN 109453071A CN 201811493122 A CN201811493122 A CN 201811493122A CN 109453071 A CN109453071 A CN 109453071A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
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- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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Abstract
The application discloses a kind of rosemary bacteriostatic hand sanitizer, it is characterized by: its raw material includes: modified Rosemary Oil 0.5-2% by weight percent, glycerol 1-3%, sodium sulfate of polyethenoxy ether of fatty alcohol 8-10%, Cocoamidopropyl betaine 4-6%, alkyl-glucoside 3-5%, citric acid 0.3-0.5%, sodium chloride 1.0-1.5%, Kathon CG 0.05-0.1%, surplus is rosemary hydrosol, rosemary cell wall rupture is made using zymolysis technique, increase substantially the recovery rate of Rosemary Oil, and in conjunction with the fragrance and active constituent in low-temperature solvent abstraction technique farthest retention of oil, can be obviously improved the flavouring essence qualities of final products with it is antibacterial, anti-inflammatory, it is antipruritic, antioxygenic property.
Description
Technical field
The invention belongs to field of daily chemicals, and in particular to a kind of rosemary bacteriostatic hand sanitizer and preparation method thereof.
Background technique
Rosemary (Rosmarinus officinalis) it is Labiatae Rosmarinus plant, Mediterranean Region is originated in,
There is large area plantation on Yunnan Province of China, Guizhou, Guangxi, Hainan and Xinjiang and other places.Rosemary contain a large amount of natural anti-oxidations at
Point, thus paid close attention to by people.Essential oil in rosemary stem, leaf has antimicrobial and anti-inflammation efficacy, can be used as stomachic tonic in medicine
And cholagog, the gasteremphraxis as caused by indigestion can be effectively relieved, alleviate small intestine and biliary spasm, enhancing flesh, which is shunk, promotes bile
Secretion, oneself is widely used in the fields such as flavorant, daily-use chemical industry and medical product.Rosemary hydrosol is steamed using vapor
The method of evaporating prepares the aqueous solution distillated when Rosemary Oil, wherein containing about 0.03% Rosemary Oil and a variety of phenols, tannin,
The water-soluble components such as protein, plant sugar, with strong rosemary fragrance.It is followed with moisturizing whitening, anti-oxidant, promotion blood
The multiple efficacies such as ring, delay skin aging.
Bacteriostatic hand sanitizer is as a kind of special hand cleanser, referred to as extraordinary hand cleanser.Mainly in common hand cleanser
On the basis of a certain amount of bacteriostasis antibiosis ingredient is added, also acted as while cleaning skin inhibition or kill skin bacterium growth
Effect.This kind of hand cleanser is mainly added to antibacterial/antimicrobial component (predominantly organic anti-bacterial on the basis of common hand cleanser
Xylenol between agent, such as Triclosan and chlorine), therefore there is stronger fungistatic effect than common hand cleanser, it can
To block the propagation of bacterial infectious disease to a certain extent.But the hand cleanser meeting of this addition organic chemical reagent is used for a long time
Larger Shanghai is caused to skin, is easy to appear dry skin, coarse and phenomena such as be chapped from the cold.In addition, chemical residue it is also possible to
In incoming mouth, larger harm is generated to human health.Many plant extracts contain a large amount of fungicide active ingredient, and to skin
Skin is non-stimulated, is a kind of green, environmental protection, the fungicide beneficial to human body.Therefore, plant extracts washing as fungicide is added
Hand liquid is more and more popular with consumers.
Summary of the invention
A kind of natural component content is provided it is an object of the invention to overcome deficiency present in the prior art, formula
High, rosemary bacteriostatic hand sanitizer of the good and easy industrialized production of effect and preparation method thereof.
The technical scheme of the present invention is realized as follows:
A kind of rosemary bacteriostatic hand sanitizer and preparation method thereof, comprising the following steps:
Step 1) pretreatment: rosemary fresh leaf is beaten, complex enzyme formulation is added, 1-3 h is digested under the conditions of 30-40 DEG C；
Step 2) extraction: by step 1) enzymatic hydrolysis after rosemary sample be placed in closed extractor, vacuumize until in extractor
Vacuum degree reaches -100 kPa, and extractant is injected into extractor, extracts after sample is totally submerged；Extraction terminate by
Liquid solvent is pumped into knockout drum, carries out constant temperature carrying out precipitation treatment simultaneously to extractor and knockout drum, respectively obtain rosemary residue with
Extract；
Step 3) distillation: step 2) it is extract obtained mixed with distilled water, progress steam distillation, separated through oil water separator
Respectively obtain Rosemary Oil and hydrosol；
Step 4) purification: by step 3) distillation gained Rosemary Oil is with constant flow rate injection molecular still, in certain item
Short-path distillation is carried out under part, the Rosemary Oil after as refining in light component receiving flask after distillation；
Step 5) modified: by step 4) Rosemary Oil after gained purification is added to certain density modification by a certain percentage
In agent aqueous solution, homogeneous is carried out under ultrasonic wave auxiliary, is freeze-dried after the completion of homogeneous, obtain modified rosemary essence
Oil.
Step 6) prepare hand cleanser: by weight percent by 0.5-2% step 5) the modified Rosemary Oil of gained with
1-3% glycerol, 8-10% sodium sulfate of polyethenoxy ether of fatty alcohol, 4-6% Cocoamidopropyl betaines, 3-5% alkyl-glucosides,
0.3-0.5% citric acid, 1.0-1.5% sodium chloride and the mixing of 0.05-0.1% Kathon CG, then with step 3) gained rosemary hydrosol benefit
It is charged to 100%, homogeneous mixes up to hand cleanser.
Step 1) described in complex enzyme formulation additive amount be rosemary gross mass 1-5%, complex enzyme formulation be fibre
The mixture of plain enzyme, hemicellulase and glucosidase is tieed up, mixing mass ratio is 1:0.5-1:0.4-0.8.
Step 2) described in extractant be dimethyl ether (DME) and tetrafluoroethane (R134a) mixture, mixing ratio
Example is volume ratio 1:0.5-1.
Step 2) described in the mass volume ratio of rosemary raw material and extractant be 1:3-12 g/ml, extraction time is
5-30 minutes, temperature be 30-45 DEG C, pressure be 0.3-0.6 Mpa, cycling extraction 1-3 time.
Step 2) described in precipitation temperature be 30-45 DEG C.
Step 3) described in the mass volume ratio of extract and distilled water be 1:1-5 g/ml, steam distillation temperature 100
DEG C, 60-90 min of distillation time.
Step 4) described in short-path distillation condition are as follows: vacuum degree≤0.013 Pa, 2-4 mL/min of material flow are scraped
400-500 rpm of film revolving speed, 100-110 DEG C of vapo(u)rizing temperature.
Step 5) described in the mass volume ratio of Rosemary Oil and modifier aqueous solution be 1:250-500 g/ml.
Step 5) described in modifier aqueous solution be hydroxypropyl-β1-5% aqueous solution of cyclodextrin or chitosan.
Step 5) described in ultrasonic wave auxiliary power be 0.2-0.8 Kw, 2450 MHz of microwave frequency, homogeneous stirring speed
Spend 15000-25000 rpm, 15-30 min of time, vacuum freeze drying condition are as follows:-60 DEG C of 24 h of pre-freeze, 30 DEG C of dryings
24-48 h, 100 Pa of vacuum degree.
Step 6) described in modified Rosemary Oil, glycerol, sodium sulfate of polyethenoxy ether of fatty alcohol, coconut oleoyl amine
Propyl betaine, alkyl-glucoside, citric acid, sodium chloride and Kathon CG with mass fraction 0.5-2%, 1-3%, 8-10%, 4-6%,
3-5%, 0.3-0.5%, 1.0-1.5% and 0.05-0.1% ratio mixing, and 100% is supplemented to rosemary hydrosol.
Step 6) described in 5000-10000 rpm of homogeneous mixing speed, 5-10 min of time.
The positive effect of the present invention is: (1) making rosemary cell wall rupture using zymolysis technique, make intracellular essence as far as possible
Oil releases, and increases substantially the recovery rate of Rosemary Oil, and farthest retain in conjunction with low-temperature solvent abstraction technique
Fragrance and active constituent in essential oil can be obviously improved the flavouring essence qualities of final products and antibacterial, anti-inflammatory, antipruritic, anti-oxidant
Etc. performances, and be free from side effects.(2) to Rosmarinus officinalis extract rather than fresh leaf carry out steam distillation, greatly improve water steaming
The processing capacity of steam distillation shortens the production cycle while reducing energy consumption.(3) rosemary is handled using molecular distillation technique
Extract can farthest prevent dissolvent residual and obtain the Rosemary Oil of very high purity, promote product quality.(4)
Rosemary Oil is modified using microcapsule embedded technology, improve its dissolution, release etc. characteristics, make its fragrance persistently, tool
There is the longer antibacterial time.
In short, rosemary bacteriostatic hand sanitizer natural component content prepared by the present invention is high, effect is good, have very wide
Application prospect.
Specific embodiment
A kind of rosemary bacteriostatic hand sanitizer and preparation method thereof, comprising the following steps:
Step 1) pretreatment: rosemary fresh leaf sample is beaten, the complex enzyme formulation (cellulose of sample total weight 1-5% is added
The mass ratio of enzyme, hemicellulase and glucosidase is 1:0.5-1:0.4-0.8), 1-3 is digested under the conditions of 30-40 DEG C
h；
Step 2) extraction: by step 1) pretreated rosemary fresh leaf is placed in closed extractor, it vacuumizes until extractor
Interior vacuum degree reaches-100 kPa, and DME and R134a(1:0.5-1 is injected into extractor), sample is totally submerged, item is extracted
Part is that the mass volume ratio of raw material and extractant is 1:3-12 g/ml, extraction time 5-30 minutes, 30-45 DEG C of temperature, and pressure
0.3-0.6 Mpa of power, cycling extraction 1-3 time；Extraction terminates liquid solvent being pumped into knockout drum, simultaneously to extractor and knockout drum
It carries out constant temperature and subtracts molten processing, 30-45 DEG C of precipitation temperature, obtain sample and extract extracted；
Step 3) distillation: step 2) it is extract obtained mixed with distilled water by mass volume ratio 1:1-5 g/ml, 100 DEG C steam
60-90 min are evaporated, through the isolated Rosemary Oil of oil water separator and hydrosol；
Step 4) purification: by step 3) distillation gained Rosemary Oil with constant flow rate inject molecular still, distillation condition:
Vacuum degree≤0.013 Pa, 2-4 mL/min of material flow, 400-500 rpm of knifing rotating speed, steam by 100-110 DEG C of vapo(u)rizing temperature
Rosemary Oil after evaporating after collecting light component and being refined；
Step 5) it is modified: by step 4) Rosemary Oil after gained purification by mass volume ratio be 1:250-500 g/ml with
The hydroxypropyl-that concentration is 1-5%βCyclodextrin or chitosan aqueous solution mixing, 0.2-0.8 Kw ultrasonic wave auxiliary under with
15-30 min of revolving speed homogeneous of 15000-25000 rpm, after the completion of homogeneous under the conditions of-60 DEG C 24 h of pre-freeze, then at temperature
30 DEG C, dry 24-48 h under the conditions of 100 Pa of vacuum degree, obtain modified Rosemary Oil.
Step 6) prepare hand cleanser: by weight percent by 0.5-2% step 5) the modified Rosemary Oil of gained with
1-3% glycerol, 8-10% sodium sulfate of polyethenoxy ether of fatty alcohol, 4-6% Cocoamidopropyl betaines, 3-5% alkyl-glucosides,
0.3-0.5% citric acid, 1.0-1.5% sodium chloride and the mixing of 0.05-0.1% Kathon CG, and it is supplemented to 100% with rosemary hydrosol,
5-10 min of homogeneous is under 5000-10000 rpm revolving speeds to get rosemary bacteriostatic hand sanitizer.
Embodiment 1
500 g rosemary fresh leafs are beaten, 1% complex enzyme formulation (cellulase, hemicellulase and glucosidase is added
Mass ratio is 1:0.6:0.6), 2.5 h are digested under the conditions of 30 DEG C；Fresh leaf slurry is placed in closed extractor after the completion of enzymatic hydrolysis,
Vacuumize until vacuum degree reaches -100 kPa in extractor, DME and R134a(v/v, 1:0.5 injected into extractor), it will
Sample is totally submerged, and the mass volume ratio of raw material and hybrid extraction solvent is 1:10 g/ml, and extraction time 25 minutes, temperature 40
DEG C, 0.5 Mpa of pressure, cycling extraction 2 times；Extraction terminates liquid solvent being pumped into knockout drum, simultaneously to extractor and knockout drum
Constant temperature carrying out precipitation treatment is carried out, 40 DEG C of precipitation temperature, respectively obtains sample and extract extracted；By extract obtained and steaming
Distilled water is mixed by mass volume ratio 1:4 g/ml, 100 DEG C of 70 min of distillation, through the isolated Rosemary Oil of oil water separator
With hydrosol.
Gained Rosemary Oil is injected into molecular still, distillation condition: vacuum degree≤0.013 with 4 mL/min flow velocitys
Pa, 480 rpm of knifing rotating speed, are collecting light component and are being 1:350 by mass volume ratio after distillation by 102 DEG C of vapo(u)rizing temperature
The hydroxypropyl-that g/ml and concentration are 1.5%βCyclodextrin aqueous solution mixing, with 18000 rpm's under 0.6 Kw ultrasonic wave auxiliary
15 min of revolving speed homogeneous, after the completion of homogeneous under the conditions of -60 DEG C 24 h of pre-freeze, then at 30 DEG C of temperature, 100 Pa item of vacuum degree
Dry 36 h, obtain modified Rosemary Oil under part.
Each component is mixed by formula shown in table 1, is washed with 7 min of revolving speed homogeneous of 8000 rpm to get rosemary is antibacterial
Hand liquid.
The formula of 1 embodiment of table, 1 rosemary bacteriostatic hand sanitizer
The performance of the made rosemary bacteriostatic hand sanitizer of the present embodiment is as shown in table 2.1 institute of the embodiment of the present invention as can be seen from the table
Hand cleanser processed have good heat-resistant stability, resistance to cold stability and 5 min foam volume performances, gross activity content of material with
And it is significant to the rejection ability aspect of performance of the bacterial strains such as staphylococcus aureus, Escherichia coli, bacillus subtilis, salmonella
Better than certain commercially available hand cleanser, and it is non-stimulated to skin, it is a kind of product for meeting people's good life needs.
The performance of the made rosemary bacteriostatic hand sanitizer of 2 embodiment of table 1
Embodiment 2
By 400 g rosemary fresh leafs be beaten, be added 3% complex enzyme formulation (cellulase: hemicellulase: glucosidase=
1:1:0.6), 3 h are digested under the conditions of 30 DEG C；Fresh leaf slurry is placed in closed extractor after the completion of enzymatic hydrolysis, is vacuumized until extraction
Take vacuum degree in tank to reach -100 kPa, DME and R134a(v/v, 1:1 injected into extractor), sample is totally submerged, it is former
Expect to be 1:10 g/ml with the mass volume ratio of hybrid extraction solvent, extraction time 30 minutes, 35 DEG C of temperature, 0.4 Mpa of pressure,
Cycling extraction 3 times；Extraction terminates liquid solvent being pumped into knockout drum, carries out at constant temperature precipitation simultaneously to extractor and knockout drum
Reason, respectively obtains sample and extract extracted by 35 DEG C of precipitation temperature；Quality volume is pressed with distilled water by extract obtained
It is mixed than 1:5 g/ml, 100 DEG C of 60 min of distillation, through the isolated Rosemary Oil of oil water separator and hydrosol.
Gained Rosemary Oil is injected into molecular still, distillation condition: vacuum degree≤0.013 with 4 mL/min flow velocitys
Pa, 500 rpm of knifing rotating speed, are collecting light component and are being 1:400 by mass volume ratio after distillation by 110 DEG C of vapo(u)rizing temperature
G/ml is mixed with the chitosan aqueous solution that concentration is 2.3%, with the revolving speed homogeneous of 16000 rpm under 0.8 Kw ultrasonic wave auxiliary
20 min, after the completion of homogeneous under the conditions of -60 DEG C 24 h of pre-freeze, it is dry under the conditions of 30 DEG C of temperature, 100 Pa of vacuum degree
40 h obtain modified Rosemary Oil.
Each component is mixed by formula shown in table 3, is washed with 5 min of revolving speed homogeneous of 9000 rpm to get rosemary is antibacterial
Hand liquid.
The formula of 3 embodiment of table, 2 rosemary bacteriostatic hand sanitizer
The performance of the made rosemary bacteriostatic hand sanitizer of the present embodiment is as shown in table 4.2 institute of the embodiment of the present invention as can be seen from the table
Hand cleanser processed have good heat-resistant stability, resistance to cold stability and 5 min foam volume performances, gross activity content of material with
And it is significant to the rejection ability aspect of performance of the bacterial strains such as staphylococcus aureus, Escherichia coli, bacillus subtilis, salmonella
Better than certain commercially available hand cleanser, and it is non-stimulated to skin, it is a kind of product for meeting people's good life needs.
The performance of the made rosemary bacteriostatic hand sanitizer of 4 embodiment of table 2
Embodiment 3
The made modified Rosemary Oil of Example 1 and hydrosol are mixed each component by formula shown in table 5, with 8000 rpm
5 min of revolving speed homogeneous to get rosemary bacteriostatic hand sanitizer.
The formula of 5 embodiment of table, 3 rosemary bacteriostatic hand sanitizer
The performance of the made rosemary bacteriostatic hand sanitizer of the present embodiment is as shown in table 6.3 institute of the embodiment of the present invention as can be seen from the table
Hand cleanser processed have good heat-resistant stability, resistance to cold stability and 5 min foam volume performances, gross activity content of material with
And it is significant to the rejection ability aspect of performance of the bacterial strains such as staphylococcus aureus, Escherichia coli, bacillus subtilis, salmonella
Better than certain commercially available hand cleanser, and it is non-stimulated to skin, it is a kind of product for meeting people's good life needs.
The performance of the made rosemary bacteriostatic hand sanitizer of 6 embodiment of table 3
Embodiment 4
The made modified Rosemary Oil of Example 2 and hydrosol are mixed each component by formula shown in table 7, with 8500 rpm
5 min of revolving speed homogeneous to get rosemary bacteriostatic hand sanitizer.
The formula of 7 embodiment of table, 4 rosemary bacteriostatic hand sanitizer
The performance of the made rosemary bacteriostatic hand sanitizer of the present embodiment is as shown in table 8.As can be seen from the table, although the present invention is implemented
Glycerol, sodium sulfate of polyethenoxy ether of fatty alcohol, Cocoamidopropyl betaine, alkyl-glucoside, lemon in the made hand cleanser of example 4
The basic ingredients content such as lemon acid, sodium chloride and Kathon CG decreases, but still have good heat-resistant stability, resistance to cold stability and
5 min foam volume performances, gross activity content of material and to staphylococcus aureus, Escherichia coli, bacillus subtilis,
The rejection ability aspect of performance of the bacterial strains such as salmonella is significantly better than certain commercially available hand cleanser, and non-stimulated to skin, is a kind of symbol
Close the product that people's good life needs.
The performance of the made rosemary bacteriostatic hand sanitizer of 8 embodiment of table 4
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not intended to limit the invention, the present disclosure applies equally to
Other sample classes.Any person skilled in the art, without departing from the spirit and scope of the present invention, can all do various change with
Modification, therefore protection scope of the present invention should subject to the definition of the claims.
Claims (10)
1. a kind of rosemary bacteriostatic hand sanitizer, it is characterised in that: its raw material includes: modified rosemary essence by weight percent
Oily 0.5-2%, glycerol 1-3%, sodium sulfate of polyethenoxy ether of fatty alcohol 8-10%, Cocoamidopropyl betaine 4-6%, alkyl grape
Glucosides 3-5%, citric acid 0.3-0.5%, sodium chloride 1.0-1.5%, Kathon CG 0.05-0.1%, surplus are rosemary hydrosol.
2. rosemary bacteriostatic hand sanitizer according to claim 1, it is characterised in that: its raw material includes: by weight percent
Modified Rosemary Oil 0.5%, glycerol 1%, sodium sulfate of polyethenoxy ether of fatty alcohol 8%, Cocoamidopropyl betaine 4%,
Alkyl-glucoside 3%, citric acid 0.3%, sodium chloride 1.0%, Kathon CG 0.05%, surplus are rosemary hydrosol.
3. the preparation method of rosemary bacteriostatic hand sanitizer according to claim 1, it is characterised in that: the following steps are included:
Step 1) pretreatment: rosemary fresh leaf is beaten, complex enzyme formulation is added, 1-3 h is digested under the conditions of 30-40 DEG C；
Step 2) extraction: by step 1) enzymatic hydrolysis after rosemary sample be placed in closed extractor, vacuumize until in extractor
Vacuum degree reaches -100 kPa, and extractant is injected into extractor, extracts after sample is totally submerged；Extraction terminate by
Liquid solvent is pumped into knockout drum, carries out constant temperature carrying out precipitation treatment simultaneously to extractor and knockout drum, respectively obtain rosemary residue with
Extract；
Step 3) distillation: by step 2) it is extract obtained mix with distilled water, progress steam distillation, through oil water separator divide
From respectively obtaining Rosemary Oil and hydrosol；
Step 4) purification: by step 3) and gained Rosemary Oil is distilled with constant flow rate injection molecular still, carry out short distance
Distillation, the Rosemary Oil after as being refined in light component receiving flask after distillation；
Step 5) modified: by step 4) Rosemary Oil after gained purification is added in modifier aqueous solution, in ultrasonic wave
Auxiliary is lower to carry out homogeneous, is freeze-dried after the completion of homogeneous, obtains modified Rosemary Oil；
Step 6) prepare hand cleanser: by weight percent by step 5) obtained in modified Rosemary Oil 0.5-2% with
1-3% glycerol, 8-10% sodium sulfate of polyethenoxy ether of fatty alcohol, 4-6% Cocoamidopropyl betaines, 3-5% alkyl-glucosides,
0.3-0.5% citric acid, 1.0-1.5% sodium chloride and the mixing of 0.05-0.1% Kathon CG, then with step 3) gained rosemary hydrosol benefit
It is charged to 100%, homogeneous stirs and evenly mixs up to hand cleanser.
4. the preparation method of rosemary bacteriostatic hand sanitizer according to claim 3, it is characterised in that: step 1) described in
Complex enzyme formulation additive amount be rosemary fresh leaf gross mass 1-5%, complex enzyme formulation be cellulase, hemicellulase
With the mixture of glucosidase, mixing mass ratio is 1:0.5-1:0.4-0.8.
5. the preparation method of rosemary bacteriostatic hand sanitizer according to claim 3, it is characterised in that: step 2) described in
Extractant is the mixture of dimethyl ether (DME) and tetrafluoroethane (R134a), and mixed proportion is volume ratio 1:0.5-1；
Step 2) described in the mass volume ratio of rosemary raw material and extractant be 1:3-12 g/ml, extraction time is 5-30
Minute, temperature be 30-45 DEG C, pressure be 0.3-0.6 Mpa, cycling extraction 1-3 time；
Step 2) described in precipitation temperature be 30-45 DEG C.
6. the preparation method of rosemary bacteriostatic hand sanitizer according to claim 3, it is characterised in that: step 3) described in
The mass volume ratio of extract and distilled water be 1:1-5 g/ml, 100 DEG C of steam distillation temperature, distillation time 60-90
min。
7. the preparation method of rosemary bacteriostatic hand sanitizer according to claim 3, it is characterised in that: step 4) described in
The condition of short-path distillation are as follows: vacuum degree≤0.013 Pa, 2-4 mL/min of material flow, 400-500 rpm of knifing rotating speed steam
Evaporate 100-110 DEG C of temperature.
8. according to the preparation method of the described in any item rosemary bacteriostatic hand sanitizers of claim 3-7, it is characterised in that: step
Five) mass volume ratio of Rosemary Oil described in and modifier aqueous solution is 1:250-500 g/ml；
Step 5) described in modifier aqueous solution be hydroxypropyl-β1-5% aqueous solution of cyclodextrin or chitosan.
9. according to the preparation method of the described in any item rosemary bacteriostatic hand sanitizers of claim 3-7, it is characterised in that: step
Five) ultrasonic wave auxiliary power described in is 0.2-0.8 Kw, 2450 MHz of microwave frequency, homogeneous mixing speed 15000-25000
Rpm, 15-30 min of time, vacuum freeze drying condition are as follows:-60 DEG C of pre-freeze 24 h, 30 DEG C of 24-48 h of drying, vacuum degree
100 Pa。
10. according to the preparation method of the described in any item rosemary bacteriostatic hand sanitizers of claim 3-7, it is characterised in that: step
Six) 5000-10000 rpm of homogeneous mixing speed described in, 5-10 min of time.
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| CN (1) | CN109453071A (en) |
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| CN112336657A (en) * | 2019-08-06 | 2021-02-09 | 广州御延堂生物科技有限公司 | Cleaning and disinfecting hand sanitizer and preparation method thereof |
| CN114557922A (en) * | 2022-03-16 | 2022-05-31 | 全芯生物科技(澳门)有限公司 | Rosemary essential oil face cream and preparation method thereof |
| CN114917164A (en) * | 2022-06-27 | 2022-08-19 | 哈尔滨工业大学重庆研究院 | Antibacterial hand sanitizer containing hawk tea extract and preparation method thereof |
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Cited By (4)
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|---|---|---|---|---|
| CN112336657A (en) * | 2019-08-06 | 2021-02-09 | 广州御延堂生物科技有限公司 | Cleaning and disinfecting hand sanitizer and preparation method thereof |
| CN114557922A (en) * | 2022-03-16 | 2022-05-31 | 全芯生物科技(澳门)有限公司 | Rosemary essential oil face cream and preparation method thereof |
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| CN114917164A (en) * | 2022-06-27 | 2022-08-19 | 哈尔滨工业大学重庆研究院 | Antibacterial hand sanitizer containing hawk tea extract and preparation method thereof |
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Application publication date: 20190312 |