CN109452489A - The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body - Google Patents
The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body Download PDFInfo
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- CN109452489A CN109452489A CN201811353592.XA CN201811353592A CN109452489A CN 109452489 A CN109452489 A CN 109452489A CN 201811353592 A CN201811353592 A CN 201811353592A CN 109452489 A CN109452489 A CN 109452489A
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- feed addictive
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- poultry
- florfenicol
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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Abstract
The present invention provides the feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body, belongs to field of feed.Feed addictive comprises the following components in parts by weight: 1~2 part of Radix Glycyrrhizae, 1~2 part of mung bean, 2~3 parts of peanut shell, 2~3 parts of polygonum cuspidate, 1~2 part of ginger, 1~2 part of kelp, 1~2 part of dandelion and 1~2 part of aloe.Radix Glycyrrhizae, polygonum cuspidate, ginger, kelp, dandelion and the common this kind of food materials of medicinal plant and mung bean and this kind of industrial chemicals of peanut shell of aloe are combined, it is played in livestock and poultry body anti-oxidant, the biological actions such as anti-apoptotic, enhance the detoxification ability of livestock and poultry liver and the detoxification ability of kidney, promotes the energetic supersession of livestock and poultry body.Experiments have shown that: the animal flesh of feeding feed stuff additive, heart, liver, kidney, lung are respectively lower than national related limit standard to the content of the Florfenicol in musculature, and feed addictive effectively eliminates Florfenicol in poultry body.
Description
Technical field
The invention belongs to field of feed, and in particular to a kind of feed addition for eliminating fluoride protector in poultry body
Agent, feed and its preparation method and application.
Background technique
Residue of veterinary drug be show livestock and poultry using accumulate and be stored in after drug cell, tissue and intraorganic veterinary drug original shape,
Metabolite and veterinary drug impurity, including residual of the veterinary drug in ecological environment and veterinary drug in animal derived agricultural product (predominantly
Meat, egg and milk etc.) any edible part residual.In general, residue of veterinary drug includes the medicine for preventing and treating livestock and poultry
Furthermore object also contacts or eats the veterinary drug pollutant in environment including Drug feed addictive, livestock and poultry.In recent years, veterinary drug
The caused food poisoning of residual and the event for influencing animal derived export of farm produce trade frequently occur, and have become the world
The hot issue of relevant functional departments, various countries extensive concern.Currently, animal derived agricultural product veterinary drug residue seriously endangers livestock and poultry
Healthy aquaculture and human animal source property agricultural product quality and safety.
Florfenicol, alias Fluprofen, Florfenicol and Florfenicol, be in last century the eighties the later period successfully grind
The broad spectrum antibiotic of the new dedicated chloromycetin of animal doctor of one kind of system.Structure homologues of the Florfenicol as chloramphenicol, effect
Mechanism and antimicrobial spectrum are similar to chloramphenicol and Thiamphenicol, can inhibit phthalein acyltransferase activity, then in conjunction with 50S subunit
Inhibit the extension of phthalein chain, the biosynthesis of interferencing protein.China in approval Florfenicol in 2000 be the new beast of national two classes
Medicine has the characteristics that has a broad antifungal spectrum, absorbability are good, widely distributed and efficient in vivo, thin to livestock and poultry caused by common sensitive bacteria
Bacterium property disease prevention and cure effect is more significant.Currently, since chloramphenicol is disabled already, as the chloromycetin drug of a new generation,
Florfenicol has become the choice drug of current prevention and treatment poultry respiratory and alimentary canal bacterial infection disease.Therefore, fluorobenzene Buddhist nun
Examining is poultry (laying hen disabling) main residual animal medicine in vivo.Remaining Florfenicol main source is due to disease in poultry body
Disease prevention and treatment during Florfenicol use, drunk by Florfenicol pollute drinking-water or searched for food by Florfenicol pollution
Crops etc..In the Ministry of Agriculture, China No. 235 bulletin " animal food herbal medicine maximum residue limit " clear stipulaties poultry body
Florfenicol maximum residue limit.
It is big that remaining harmfulness is examined from the Fluorine in Foods benzene Buddhist nun of poultry, especially for children and the elderly, harm
It is more serious.Poultry based food is once polluted by Florfenicol, it is difficult to be thoroughly removed, and general cooking process is difficult to eliminate fluorine
Benzene Buddhist nun examines residual.Fluoride protector not only directly can generate acute and chronic toxic effect to human body, cause bacterial drug resistance
Increase, but also human health can be caused indirectly potentially hazardous by the effect of environment and food chain.Florfenicol tool
There are teratogenesis, carcinogenic and mutagenic effect, the allergic reaction of humans and animals, disturbance endocrine function, damage life can also be caused
Grow system function.In addition, fluoride protector influences poultry and people to the drug resistance of pathogen, it is flat to destroy microorganism in gastrointestinal tract
Weighing apparatus makes body easily send out infectious diseases, and greatly improves treatment difficulty due to generating drug resistance.Reduce the intracorporal fluorine of poultry
Benzene Buddhist nun, which examines residual, will can ensure the safety of animality agricultural product, prevent due to having eaten the exceeded family's avian of fluoride protector
Human health risk caused by agricultural production.In addition, family's avian agriculture in China can be promoted by reducing poultry fluoride protector
The competitiveness in international market of product promotes the good development of foreign trade, remarkable in economical benefits.Therefore, it takes effectively
Measure it is very urgent come the generation for reducing and controlling fluoride protector in family's avian agricultural product.
Currently, although countries in the world still face many difficulties to the prevention and control pay attention to day by day of poultry fluoride protector,
Florfenicol is excessively used as poultry feeders blindly pursue productivity effect, not the administrative provisions of strict implement drug off-drug period
Deng.Still lack the drug for safely and effectively reducing poultry fluoride protector at present.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of feed additions of fluoride protector in elimination poultry body
Agent, feed and its preparation method and application, the feed addictive can effectively eliminate poultry fluoride protector, and safety is without pair
Effect.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of feed addictives of fluoride protector in elimination poultry body, including following parts by weight
Component: 1~2 part of Radix Glycyrrhizae, 1~2 part of mung bean, 2~3 parts of peanut shell, 2~3 parts of polygonum cuspidate, 1~2 part of ginger, 1~2 part of kelp, Pu Gong
1~2 part and 1~2 part of aloe of English.
Preferably, it comprises the following components in parts by weight: 1.5 parts of Radix Glycyrrhizae, 1.5 parts of mung bean, 2.5 parts of peanut shell, polygonum cuspidate 2.5
Part, 1.5 parts of ginger, 1.5 parts of kelp, 1.5 parts of dandelion and 1.5 parts of aloe.
The present invention provides the preparation methods of the feed addictive, by Radix Glycyrrhizae, mung bean, peanut shell, polygonum cuspidate, ginger, sea
Band, dandelion and aloe are successively dry, crush, sieving, and fine powder obtains feed addictive under collection screen.
Preferably, the temperature of the drying is 40~60 DEG C；The time of the drying is 6~8h.
Preferably, the partial size of the fine powder is 200~300 mesh.
The present invention provides a kind of feeds of fluoride protector in elimination poultry body, including poultry basal feed and described
Feed addictive；
The mass ratio of the feed addictive and poultry basal feed is 1:500~1000.
The feed addictive or the feed prepared the present invention provides the feed addictive, the method is disappearing
Except the application in poultry body in fluoride protector.
Preferably, the feed addictive or feed are fed house by the method for eliminating fluoride protector in poultry body
Fowl.
Preferably, the scale of feeding of the feed addictive is 0.03~0.1g/ times, is fed 2~3 times within one day, the day of feeding
Number is 7~10d.
Preferably, the scale of feeding of the feed is 50~200g/ time, is fed 2~3 times within one day, the number of days of feeding for 7~
10d。
The present invention provides a kind of feed addictives of fluoride protector in elimination poultry body, and the present invention is according to fluorobenzene Buddhist nun
The rule for remaining in poultry body intracellular metabolite is examined, using reasonable technical measures, using stronger with decorporation Florfenicol effect
Various bioactivators form compound, provide one kind and Florfenicol remaining feed addition in poultry body is effectively reduced
Agent.By Radix Glycyrrhizae, polygonum cuspidate, ginger, kelp, dandelion and aloe it is common this kind of food materials of medicinal plant and mung bean and peanut shell it is this kind of
The effect of industrial chemicals is combined, and Radix Glycyrrhizae plays and invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription,
Polygonum cuspidate plays expelling wind and removing dampness, scattered stasis pain, relieving cough and reducing sputum effect；Ginger expelling cold, eliminating, warming middle energizer to arrest vomiting, warm lung cough-relieving, removing toxic substances
The effect of；Kelp is rich in mineral matter elements such as iodine, calcium and iron, and with reducing blood lipid, antioedematous, hypoglycemic, adjusting is immune, anti-artery
Hardening, anticoagulation and the various biologicals effect such as antitumor；Dandelion has inhibiting bacteria and diminishing inflammation effect；Aloe is rich in aloearbonaside, reed
Luxuriant growth rheum emodin, Aloesin, aloe polysaccharide and aloe saponin, while containing there are many amino acid, organic acid, cellulose, active matters
Matter, ferment substance and microelement, have improve blood circulation, activation and the intracorporal beneficial flora of proliferation machine, anti-inflammatory, analgesia,
Hemostasis, effect that is sun-proof, promoting wound healing, calmness and enhancing immune function；Mung bean play it is clearing heat and detoxicating, relieve summer heat, stopping leak dysentery,
Li Shui, antibacterial, antibacterial effect；Peanut shell plays lowering blood pressure and blood fat, antiviral, inhibition tumour and promotes gastrointestinal disturbances
Function.By said components compatibility, can cancel out each other the present invention toxic side effect, and enhance respective pharmacotoxicological effect.The feed
Additive plays anti-oxidant, the biological actions such as anti-apoptotic in livestock and poultry body, enhances the detoxification ability and kidney of livestock and poultry liver
Detoxification ability, promote livestock and poultry body energetic supersession, for prevention and control poultry fluoride protector provide one kind newly by way of.By this hair
The biological action of various plant origin compounds in bright promotes poultry growth and promotes the general level of the health of poultry, can get
Preferable economic and social benefit meets the policy of national poultry healthy aquaculture and green food.
Meanwhile feed addictive provided by the invention, the component of selection are plant origin, and have from a wealth of sources, nothing
Toxic side effect, cost is relatively low, prepares the features such as simple and easy to use, and application prospect is good.
Specific embodiment
The present invention provides a kind of feed addictives of fluoride protector in elimination poultry body, including following parts by weight
Component: 1~2 part of Radix Glycyrrhizae, 1~2 part of mung bean, 2~3 parts of peanut shell, 2~3 parts of polygonum cuspidate, 1~2 part of ginger, 1~2 part of kelp, Pu Gong
1~2 part and 1~2 part of aloe of English.
Feed addictive provided by the invention includes Radix Glycyrrhizae.By weight, the Radix Glycyrrhizae includes 1~2 part, more preferably
1.5 part.The Radix Glycyrrhizae: alias state is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root.Pulse family, Glycyrrhiza perennial herb, root and root shape
Stem thickness is strong, is a kind of help Chinese herbal medicine.With invigorating the spleen and benefiting qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, the function of coordinating the drug actions of a prescription
Effect.It is usually used in weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus resists swollen
Tumor.
Feed addictive provided by the invention includes polygonum cuspidate.By weight, the polygonum cuspidate includes 2~3 parts, more preferably
2.5 part.The polygonum cuspidate: polygonaceae belongs to herbaceos perennial.Rhizomes hyoscine has expelling wind and removing dampness, scattered stasis pain, cough-relieving
The effect of resolving sputum.For treating arthralgia, jaundice with damp-heat pathogen, menostasis, abdominal mass, scald, injury from falling down, carbuncle sore tumefacting virus, cough
The diseases such as abundant expectoration of coughing.
Feed addictive provided by the invention includes ginger.By weight, the ginger includes 1~2 part, more preferably
1.5 part.The ginger, alias have race, Bailayun, another name for ginger, hook finger, because ground is pungent, cool kid, fresh ginger, belong to Zingiber, it is perennial
The fresh rhizome of herbaceous plant ginger.Ginger acrid flavour, slightly warm in nature.Return lung, spleen, stomach meridian.With expelling cold, eliminating, warming middle energizer to arrest vomiting, warm lung
The effect of cough-relieving, removing toxic substances, is usually used in treating anemofrigid cold, taste sympotoms caused by cold factors, gastrofrigid vomiting, solving toxin of fish and crab, lung cold cough, rheumatism numbness
Bitterly, taste-blindness rate etc..
Feed addictive provided by the invention includes kelp.By weight, the kelp includes 1~2 part, more preferably
1.5 part.The kelp alias thallus laminariae, river Chinese cabbage, synthetic fibre cloth, Hai Kunbu, hippocampus Lin, kelp dish, sea grass Phaeophyta swim Sporozoa sea
Band mesh Laminariaceae Larminaria, it is flexible to gain the name like band because it is grown in seawater.The mineral such as kelp iodine rich in, calcium and iron
Prime element is both a kind of very high vegetables of nutritive value, it may have certain medical value has reducing blood lipid, antioedematous, drop blood
Sugar adjusts immune, anti arteriosclerosis, anticoagulation and the various biologicals effect such as antitumor.
Feed addictive provided by the invention includes dandelion.By weight, the dandelion includes 1~2 part, more excellent
It is selected as 1.5 parts.The dandelion, alias chrysanthemum seedling, Po Poding, dandelion, chrysanthemum youth, the wooden Chinese yam, slurry is very thin, mend patch,
Milk or bitter Mu etc., herbaceos perennial.Acute mastitis is cured mainly, parotitis, adenolymphitis, scrofula, carbuncle toxin is treated, is acute
Conjunctivitis, pharyngitis, cat fever, acute tonsillitis, rheumatic arthritis, acute bronchitis, gastritis, hepatitis, pneumonia, gallbladder
Capsulitis, acute and chronic appendicitis, urinary system infection contamination, osteomyelitis, vaginitis, pelvic inflammatory disease, duodenal ulcer, acne, acne, calculus
The tens of kinds of illnesss such as disease and kinds cancer.
Feed addictive provided by the invention includes aloe.By weight, the aloe includes 1~2 part, more preferably
1.5 part.The maximum effective component of content is aloearbonaside, aloe-emodin, Aloesin, aloe polysaccharide and aloe in the aloe
Saponin, while also there are many amino acid, organic acid, cellulose, active material, ferment substance and microelements etc..With improvement
Blood circulation, activation and the intracorporal beneficial flora of proliferation machine, anti-inflammatory, analgesia, hemostasis, sun-proof, promotion wound healing, calmness and increasing
The effect of strong immune function, can treat ulcer, constipation, wet tinea, infantile malnutrition and colitis, and a kind of natural preservative and
Wetting agent.
Feed addictive provided by the invention includes mung bean.By weight, the mung bean includes 1~2 part, more preferably
1.5 part.The mung bean alias Semen phaseoli radiati, Lu beans, plant beans etc., belong to pulse family.Major function be it is clearing heat and detoxicating, relieve summer heat, stopping leak dysentery,
Li Shui, antibacterial, antibacterial, reducing blood lipid and antitumor.
Feed addictive provided by the invention includes peanut shell.By weight, the peanut shell includes 2~3 parts, more excellent
It is selected as 2.5 parts.The peanut shell has the function of lowering blood pressure and blood fat, antiviral, inhibition tumour and promotes gastrointestinal disturbances.
The present invention provides the preparation methods of the feed addictive, by Radix Glycyrrhizae, mung bean, peanut shell, polygonum cuspidate, ginger, sea
Band, dandelion and aloe are successively dry, crush, sieving, and fine powder obtains feed addictive under collection screen.
In the present invention, the temperature of the drying is preferably 40~60 DEG C；The time of the drying is preferably 6~8h.Institute
The partial size for stating fine powder is preferably 200~300 mesh.The present invention is not particularly limited the method for the drying, crushing, sieving, adopts
With the scheme of drying known in the art, crushing, sieving.
The present invention provides a kind of feeds of fluoride protector in elimination poultry body, including poultry basal feed and described
Feed addictive；The mass ratio of the feed addictive and poultry basal feed be 1:500~1000, preferably 1:600~
900, more preferably 1:700~800, most preferably 1:750.The present invention does not do specifically the type of poultry basal feed and source
It limits, using poultry basal feed known in the art.
In the present invention, the preparation method of the feed is preferably by the poultry basal feed and the feed addictive
It is mixed.
The feed addictive or the feed prepared the present invention provides the feed addictive, the method is disappearing
Except the application in poultry body in fluoride protector.
In the present invention, the method for eliminating fluoride protector in poultry body is preferably by the feed addictive or feeding
Expect feed for poultry.The scale of feeding of the feed addictive is preferably 0.03~0.1g/ times, preferred feeding in one day 2~3 times, feeding
Number of days be preferably 7~10d, more preferably 8d.The scale of feeding of the feed is preferably 50~200g/ times, preferred feeding 2 in one day
~3 times, the number of days of feeding is preferably 7~10d, more preferably 8d.
Using feed addictive provided by the invention or feed raise poultry animal, as a result, it has been found that: it is examined using national standard
Survey method detects the Florfenicol content in each group Muscle of chicken tissue respectively on high performance liquid chromatograph.The result shows that raising
The respectively lower than national related limitation mark of the feed additives group broiler chicken heart, liver, kidney, lung and the content of the Florfenicol in musculature
It is quasi-.This shows that plant origin additive of the invention significantly reduces Florfenicol in the accumulation of above-mentioned organ.
Below with reference to embodiment to it is provided by the invention it is a kind of eliminate poultry body in fluoride protector feed addictive,
Feed and its preparation method and application is described in detail, but they cannot be interpreted as the limit to the scope of the present invention
It is fixed.
Embodiment 1
Weigh following dry matter component mixing, Radix Glycyrrhizae 1kg, mung bean 1kg, peanut shell 2kg, polygonum cuspidate 2kg, ginger 1kg, kelp
1kg, dandelion 1kg and aloe 1kg.
Above-mentioned plant origin mixture is placed in the dry 6h of 50 DEG C of Constant Temp. Ovens.
Plant mixture is crushed through pulverizer, grinding time 20min, then successively through 50 mesh, 100 mesh and 300 mesh
Sieving, fine powder under collection screen, obtains feed addictive.
The feed addictive prepared is added to feed mixing machine, by feed addictive and poultry feed according to 1:500
Mass ratio be added feed in, be uniformly mixed, the feed of fluoride protector in the poultry body that is eliminated.
Embodiment 2
Weigh following dry matter component mixing, Radix Glycyrrhizae 2kg, mung bean 2kg, peanut shell 3kg, polygonum cuspidate 3kg, ginger 2kg, kelp
2kg, dandelion 2kg and aloe 2kg.
Above-mentioned plant origin mixture is placed in the dry 8h of 50 DEG C of Constant Temp. Ovens.
Plant mixture is crushed through pulverizer, grinding time 30min, then successively through 50 mesh, 100 mesh and 300 mesh
Sieving, fine powder under collection screen, obtains feed addictive.
The feed addictive prepared is added to feed mixing machine, by feed addictive and poultry feed according to 1:1000
Mass ratio be added feed in, be uniformly mixed, the feed of fluoride protector in the poultry body that is eliminated.
Embodiment 3
Weigh following dry matter component mixing, Radix Glycyrrhizae 1.5kg, mung bean 1.5kg, peanut shell 2.5kg, polygonum cuspidate 2.5kg, ginger
1.5kg, kelp 1.5kg, dandelion 1.5kg and aloe 1.5kg.
Above-mentioned plant origin mixture is placed in the dry 7h of 50 DEG C of Constant Temp. Ovens.
Plant mixture is crushed through pulverizer, grinding time 20-30min, then successively through 50 mesh, 100 mesh and 300
Mesh filters, and fine powder under collection screen obtains feed addictive.
The feed addictive prepared is added to feed mixing machine, by feed addictive and poultry feed according to 1:800
Mass ratio be added feed in, be uniformly mixed, the feed of fluoride protector in the poultry body that is eliminated.
Embodiment 4
21 age in days health broiler chicken 80 are chosen, are divided into 4 groups: control group, Florfenicol group, treatment group and plant origin feed
Additive control group, every group of 20 chickens, half male and half female.Control group fed chow diet, the feeding of Florfenicol group are mixed with fluorobenzene
The feed that Buddhist nun examines, Florfenicol and plant origin feed addictive group are given Florfenicol (being 2g/kg with feed ratio) and are added
The feed for the feed addictive for having added embodiment 2 to prepare.
After continuous feeding 7 days, etherization acquires blood, and 3500 turns/min is centrifuged 10min, separates serum, be stored in-
It is to be measured in 20 DEG C of refrigerators.Muscle of chicken tissue is taken, is frozen in be measured in -20 DEG C of refrigerators.
Detect the fluorine in each group Muscle of chicken tissue respectively on high performance liquid chromatograph referring to national standard detection method
Benzene Buddhist nun examines content.The result shows that the feed addictive group broiler chicken heart, liver, kidney, lung and the Florfenicol in musculature content
(being shown in Table 2) respectively lower than related limit standard (being shown in Table 1) of country, meets animal derived food healthy requirement, and fluorobenzene
The content that Buddhist nun examines the broiler chicken heart organized, liver, kidney, lung and the above-mentioned Florfenicol in musculature is significantly higher than feed addition respectively
Agent group and control group show that plant origin additive of the invention significantly reduces Florfenicol in the accumulation of above-mentioned organ.
The intracorporal Florfenicol maximum residue limit of 1 poultry of table
Note: quoted from No. 235 bulletins " animal food herbal medicine maximum residue limit " of the Ministry of Agriculture.
Florfenicol concentration (μ g/kg, n=20) in the 2 broiler chicken heart of table, liver, kidney, lung and musculature
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
Serum of broilers glutathione S-transferring enzymes (glutathione is detected on ultraviolet specrophotometer using biochemical method
S-transferase, GST) (bioengineering is built up in Nanjing for active (Bioengineering Research Institute, A004 are built up in Nanjing) and total sulfydryl
Research institute, A063-1) content.Existed using 3 activity detection kit of caspase (green skies biotechnology research institute, C1115)
The activity of the apoptosis marker enzyme caspase-3 in serum of broilers is detected in all-wave length microplate reader.The results show that plant of the invention
Carry out source feed additive and is able to maintain that GST activity and total sulfhydryl content.In addition, Apoptosis marker enzyme caspase-3 activity is examined
It surveys the results show that plant origin feed addictive of the invention has effects that the Apoptosis of anti-Florfenicol induction.
3 serum of broilers drug metabolism of table and Apoptosis index of correlation testing result (n=20)
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
Liver is the most important toxicant metabolism of body and energetic supersession organ, and the normal poisonous substance to body of function converts
Play the role of with discharge main.Use ATP assay kit (Bioengineering Research Institute, A095-1 are built up in Nanjing), Na+-K+Atpase assay kit (Bioengineering Research Institute, A070-6 are built up in Nanjing) detects on ultraviolet specrophotometer respectively
Hepatic tissue ATP content and liver Na+-K+Atpase activity.It is maintained the result shows that plant origin feed addictive of the invention has
The effect of liver cell energetic supersession stable state, (is shown in Table 4).
4 broiler chicken energetic supersession index of correlation testing result (n=20) of table
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
Nanjing is respectively adopted and builds up Bioengineering Research Institute's ALT testing cassete (reitman-frankel method, C009-2) and AST testing cassete
(C010-2) detection serum of broilers ALT and AST activity.Nanjing is respectively adopted and builds up Bioengineering Research Institute's creatinine assay kit
(enzymic creatinine assay method, C011-2) and uric acid detection kit detect serum of broilers creatinine and uric acid content.The results show that raising
Feed additives effectively alleviate liver function caused by Florfenicol and renal impairment, and to the liver and kidney of healthy broiler chicken
Nonhazardous acts on (being shown in Table 5).
5 serum of broilers liver function of table and renal function biochemical indicator testing result (n=20)
Note:*Indicate significant difference compared with the control group；#Indicate significant difference (p < 0.05) compared with Florfenicol group.
Embodiment 2
2 monthly age health geese 80 are chosen, be divided into 4 groups: control group, Florfenicol group, treatment group and plant origin feed add
Add agent control group, every group of 20 geese, half male and half female.Control group fed chow diet, the feeding of Florfenicol group are mixed with fluorobenzene Buddhist nun
The feed examined, Florfenicol and plant origin feed addictive group give Florfenicol (being 2g/kg with feed ratio) and addition
The feed of 3 feed addictive of embodiment.
After continuous feeding 7 days, anesthesia acquires blood, and 3500 turns/min is centrifuged 10min, separates serum, is stored in -20 DEG C
It is to be measured in refrigerator.The goose heart, liver, kidney, lung and musculature are taken, is frozen in be measured in -20 DEG C of refrigerators.
Referring to national standard detection method on shimadzu high performance liquid chromatograph respectively detect each group goose heart, liver, kidney, lung and
Florfenicol content in musculature.The result shows that fluorobenzene Buddhist nun in the heart of Florfenicol group goose, liver, kidney, lung and musculature
The content examined is significantly higher than feed addictive group and control group respectively, the heart of feed addictive and Florfenicol joint group goose,
The content (being shown in Table 6) of Florfenicol in liver, kidney, lung and musculature is below Florfenicol group, while meeting national correlation
Limit standard meets animal derived food healthy requirement, discloses plant origin additive of the invention and significantly reduces
Accumulation of the Florfenicol in the above-mentioned organ of goose.
Florfenicol concentration (μ g/kg, n=20) in the 6 goose heart of table, liver, kidney, lung and musculature
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
Nanjing is respectively adopted and builds up Bioengineering Research Institute's ALT testing cassete (reitman-frankel method, C009-2) and AST testing cassete
(C010-2) detection serum of broilers ALT and AST activity.Nanjing is respectively adopted and builds up Bioengineering Research Institute's creatinine assay kit
(enzymic creatinine assay method, C011-2) and uric acid detection kit detect goose serum creatinine and uric acid content.The results show that feed
Additive effectively alleviates foie gras function caused by Florfenicol and renal impairment (being shown in Table 7), and to healthy Goose Liver and
Kidney nonhazardous effect.
7 goose serum liver function of table and renal function biochemical indicator testing result (μ g/kg, n=20)
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
Embodiment 3
21 age in days health ducks 80 are chosen, are divided into 4 groups: control group, Florfenicol group, plant origin feed addictive and fluorine
Benzene Buddhist nun examines joint group and plant origin feed addictive control group, every group of 20 chickens, half male and half female.Control group fed is normally raised
Material, Florfenicol group feed the feed for being mixed with Florfenicol, and Florfenicol and plant origin feed addictive group give fluorobenzene
Buddhist nun examines (being 2g/kg with feed ratio) and the feed for being added to 1 feed addictive of embodiment.
After continuous feeding 7 days, anesthesia acquires blood, and 3500 turns/min is centrifuged 10min, separates serum, is stored in -20 DEG C
It is to be measured in refrigerator.Duck musculature is taken, is frozen in be measured in -20 DEG C of refrigerators.
Detect each group duck heart, liver, kidney, lung and muscle respectively on high performance liquid chromatograph referring to national standard detection method
Florfenicol content in tissue.The result shows that the Florfenicol in the feed addictive group duck heart, liver, kidney, lung and musculature
Content (being shown in Table 8) be respectively lower than relevant national standard, meet animal derived food healthy requirement, and Florfenicol group
The duck heart, liver, kidney, lung and the above-mentioned Florfenicol in musculature content be significantly higher than feed addictive group and right respectively
According to group, discloses plant origin additive of the invention and significantly reduce Florfenicol in the accumulation of the above-mentioned organ of duck.
Florfenicol concentration (μ g/kg, n=20) in the 8 duck heart of table, liver, kidney, lung and musculature
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
Nanjing is respectively adopted and builds up Bioengineering Research Institute's ALT testing cassete (reitman-frankel method, C009-2) and AST testing cassete
(C010-2) duck Serum ALT and AST activity are detected.Nanjing is respectively adopted and builds up Bioengineering Research Institute's creatinine assay kit
(enzymic creatinine assay method, C011-2) and uric acid detection kit detect duck serum creatinine and uric acid content.The results show that feed
Additive effectively alleviates duck liver function caused by Florfenicol and renal impairment (being shown in Table 9), and to the liver of healthy duck
It is acted on kidney nonhazardous.
9 duck blood clearing liver function of table and renal function biochemical indicator testing result (n=20)
Note: * indicates significant difference compared with the control group；# indicates significant difference (p < 0.05) compared with Florfenicol group.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of feed addictive for eliminating fluoride protector in poultry body, which is characterized in that the group including following parts by weight
Point: 1~2 part of Radix Glycyrrhizae, 1~2 part of mung bean, 2~3 parts of peanut shell, 2~3 parts of polygonum cuspidate, 1~2 part of ginger, 1~2 part of kelp, dandelion
1~2 part and 1~2 part of aloe.
2. feed addictive according to claim 1, which is characterized in that comprise the following components in parts by weight: Radix Glycyrrhizae 1.5
Part, 1.5 parts of mung bean, 2.5 parts of peanut shell, 2.5 parts of polygonum cuspidate, 1.5 parts of ginger, 1.5 parts of kelp, 1.5 parts of dandelion and aloe 1.5
Part.
3. the preparation method of feed addictive of any of claims 1 or 2, which is characterized in that by Radix Glycyrrhizae, mung bean, peanut shell, tiger
Cane, ginger, kelp, dandelion and aloe are successively dry, crush, sieving, and fine powder obtains feed addictive under collection screen.
4. preparation method according to claim 3, which is characterized in that the temperature of the drying is 40~60 DEG C；It is described dry
The dry time is 6~8h.
5. preparation method according to claim 3, which is characterized in that the partial size of the fine powder is 200~300 mesh.
6. a kind of feed for eliminating fluoride protector in poultry body, which is characterized in that wanted including poultry basal feed and right
Feed addictive described in asking 1 or 2；
The mass ratio of the feed addictive and poultry basal feed is 1:500~1000.
7. the feed addition of feed addictive of any of claims 1 or 2, claim 3~5 any one the method preparation
Agent or feed as claimed in claim 6 are eliminating the application in poultry body in fluoride protector.
8. application according to claim 7, which is characterized in that the method for eliminating fluoride protector in poultry body will
The feed addictive or feed feed for poultry.
9. application according to claim 8, which is characterized in that the scale of feeding of the feed addictive is 0.03~0.1g/
It is secondary, it feeds 2~3 times within one day, the number of days of feeding is 7~10d.
10. application according to claim 8, which is characterized in that the scale of feeding of the feed is 50~200g/ times, one day
Feeding 2~3 times, the number of days of feeding are 7~10d.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811353592.XA CN109452489A (en) | 2018-11-14 | 2018-11-14 | The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811353592.XA CN109452489A (en) | 2018-11-14 | 2018-11-14 | The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body |
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| CN109452489A true CN109452489A (en) | 2019-03-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811353592.XA Pending CN109452489A (en) | 2018-11-14 | 2018-11-14 | The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110960541A (en) * | 2019-12-13 | 2020-04-07 | 西南大学 | Pharmaceutical composition for penaeus vannamei boone |
| CN111227115A (en) * | 2020-03-18 | 2020-06-05 | 广州市致善生物科技有限公司 | Feed additive and preparation method and application thereof |
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| CN102335365A (en) * | 2011-10-11 | 2012-02-01 | 张庆强 | Liver-nourishing toxin-expelling powder |
| CN104543404A (en) * | 2015-01-17 | 2015-04-29 | 东北农业大学 | Natural compound feed additive for removing veterinary drug residues |
| CN105106315A (en) * | 2015-08-28 | 2015-12-02 | 河南大德广动物药业有限公司 | Traditional Chinese medicine formulation for promoting growth and development of viscera of young poultry and preparation method thereof |
| CN105726661A (en) * | 2016-03-29 | 2016-07-06 | 郑州赛科药业科技有限公司 | Compound preparation for eliminating toxins in livestock and poultry bodies and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335365A (en) * | 2011-10-11 | 2012-02-01 | 张庆强 | Liver-nourishing toxin-expelling powder |
| CN104543404A (en) * | 2015-01-17 | 2015-04-29 | 东北农业大学 | Natural compound feed additive for removing veterinary drug residues |
| CN105106315A (en) * | 2015-08-28 | 2015-12-02 | 河南大德广动物药业有限公司 | Traditional Chinese medicine formulation for promoting growth and development of viscera of young poultry and preparation method thereof |
| CN105726661A (en) * | 2016-03-29 | 2016-07-06 | 郑州赛科药业科技有限公司 | Compound preparation for eliminating toxins in livestock and poultry bodies and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110960541A (en) * | 2019-12-13 | 2020-04-07 | 西南大学 | Pharmaceutical composition for penaeus vannamei boone |
| CN110960541B (en) * | 2019-12-13 | 2022-10-28 | 西南大学 | Pharmaceutical composition for penaeus vannamei |
| CN111227115A (en) * | 2020-03-18 | 2020-06-05 | 广州市致善生物科技有限公司 | Feed additive and preparation method and application thereof |
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Application publication date: 20190312 |