CN109432325B - Traditional Chinese medicine composition for treating infantile fever and cough and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating infantile fever and cough and preparation method thereof Download PDF

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CN109432325B
CN109432325B CN201811614594.XA CN201811614594A CN109432325B CN 109432325 B CN109432325 B CN 109432325B CN 201811614594 A CN201811614594 A CN 201811614594A CN 109432325 B CN109432325 B CN 109432325B
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cough
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chinese medicine
medicine composition
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CN109432325A (en
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华春萱
徐裕彬
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Beijing Weiren Chinese herbal decoction Factory Co.,Ltd.
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Hebei Jujing Pharmaceutical Co ltd
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Abstract

The invention relates to the field of traditional Chinese medicines for children, and in particular relates to a traditional Chinese medicine composition for treating fever and cough in children and a preparation method thereof. A traditional Chinese medicine composition for treating infantile fever and cough is mainly prepared from the following effective raw materials: by weight, 3-6 parts of tabasheer, 5-10 parts of platycodon grandiflorum, 5-10 parts of immature bitter orange, 5-10 parts of poria cocos, 5-10 parts of scutellaria baicalensis, 5-10 parts of mangnolia officinalis, 5-10 parts of pericarpium citri reticulatae, 6-10 parts of fructus forsythiae, 6-10 parts of cortex mori radicis and 6-10 parts of radix peucedani. The concretio silicea bambusae disclosed by the invention is special for heart, is formed by the essence qi of bamboo, and has slight effect on bamboo juice, so that phlegm can be removed and orifices can be benefited, but the concretio silicea bambusae has the effects of removing wind, removing heat, cooling heart, treating wind-heat phlegm surge of infantile convulsion, and has moderate property and no cold and slippery trouble compared with the bamboo juice; the composition is matched with the products of white mulberry root-bark, whiteflower hogfennel root, baical skullcap root, platycodon root, Indian buead, tangerine peel, immature bitter orange, weeping forsythia capsule and officinal magnolia bark for clearing heat and descending lung, relieving cough and descending adverse qi, strengthening spleen and eliminating stagnation, and has the functions of clearing heat and descending lung, relieving cough and eliminating phlegm.

Description

Traditional Chinese medicine composition for treating infantile fever and cough and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines for children, and in particular relates to a traditional Chinese medicine composition for treating fever and cough in children and a preparation method thereof.
Background
The infantile convulsion is caused by exopathic seasonal pestilence, internal phlegm-heat, food retention and sudden fright, which causes fever, headache, cough, red throat, nasal discharge, heavy cough, tonsillitis, dysphoria, and even convulsion and coma in high fever.
In treatment, most of the existing traditional Chinese medicine preparations are mainly used for reducing phlegm, but the phlegm eliminating force is weak, and the treatment effect needs to be further improved.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating infantile fever and cough, wherein the concretio silicea bambusae in the formula is specially used for heart, is formed by essential qi of bamboo, has little effect with bamboo juice, can dispel phlegm and benefit orifices, but the concretio silicea bambusae is capable of dispelling wind and removing heat to cool the heart, and is used for treating wind-heat phlegm surge of infantile convulsion, and compared with the bamboo juice, the traditional Chinese medicine composition has moderate nature and is free from cold and slippery; the composition is matched with the products of white mulberry root-bark, whiteflower hogfennel root, baical skullcap root, platycodon root, Indian buead, tangerine peel, immature bitter orange, weeping forsythia capsule and officinal magnolia bark for clearing heat and descending lung, relieving cough and descending adverse qi, strengthening spleen and eliminating stagnation, and has the functions of clearing heat and descending lung, relieving cough and eliminating phlegm.
The second objective of the invention is to provide a preparation method of the traditional Chinese medicine composition for treating infantile fever and cough, the liquid medicine prepared by the method has excellent curative effect, and the preparation method is simple, convenient and feasible, and is easy for industrialized production.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
a traditional Chinese medicine composition for treating infantile fever and cough is mainly prepared from the following effective raw materials: by weight, 3-6 parts of tabasheer, 5-10 parts of platycodon grandiflorum, 5-10 parts of immature bitter orange, 5-10 parts of poria cocos, 5-10 parts of scutellaria baicalensis, 5-10 parts of mangnolia officinalis, 5-10 parts of pericarpium citri reticulatae, 6-10 parts of fructus forsythiae, 6-10 parts of cortex mori radicis and 6-10 parts of radix peucedani.
The medicine of the invention has reasonable compatibility, and the compatibility principle is as follows:
the Tian Zhu Huang is sweet in flavor and cold in nature. It enters heart, liver and gallbladder meridians. Has the effects of clearing heat, eliminating phlegm, clearing heart fire and arresting convulsion. The invention takes the effects of clearing heat and eliminating phlegm, and clearing heart fire and arresting convulsion.
Platycodon root, radix Platycodi is bitter and pungent in flavor and neutral in nature. It enters lung meridian. Has effects in dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Modern pharmacological research finds that platycodon grandiflorum has the effects of eliminating phlegm, relieving cough and relieving asthma. The invention takes the effect of dispersing lung and eliminating phlegm.
Zhi Shi is bitter, pungent and sour in flavor and slightly cold in nature. It enters spleen, stomach and large intestine meridians. Has the effects of relieving stagnant qi, removing food retention, resolving phlegm and dispersing masses. The present invention takes the actions of resolving food stagnation and resolving phlegm.
Poria cocos, is sweet and bland in taste and neutral in nature. It enters heart, lung, spleen and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. The present invention takes the effect of invigorating spleen and calming heart.
Baical skullcap root, radix Scutellariae is bitter in taste and cold in nature. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. Modern pharmacological research finds that the scutellaria has the effects of relieving fever, tranquilizing and relieving spasm. The invention takes the heat-clearing effect.
Hou Po is bitter and pungent in flavor and warm in nature. It enters spleen, stomach, lung and large intestine meridians. Has effects in promoting qi circulation, eliminating dampness, resolving food stagnation, and relieving asthma. The present invention takes the actions of resolving food stagnation and relieving dyspnea.
Tangerine peel is bitter and pungent in flavor and warm in nature. It enters lung and spleen meridians. Has the effects of regulating qi, invigorating spleen, eliminating dampness and phlegm. Modern pharmacological research finds that the volatile oil contained in the dried orange peel has the effect of stimulating and eliminating phlegm. The present invention takes its effect of invigorating spleen and resolving phlegm.
Forsythia fruit is bitter in taste and slightly cold in nature. It enters lung, heart and small intestine meridians. Has the effects of clearing away heat and toxic materials, relieving swelling, and dispersing pathogenic accumulation. Modern pharmacological research finds that the forsythia has the antipyretic effect. The present invention takes the actions of clearing heat and removing toxicity.
Sang Bai Pi is sweet in flavor and cold in nature. It enters lung meridian. Has the effects of purging lung, relieving asthma, inducing diuresis and relieving swelling. Modern pharmacological research finds that the cortex mori radicis has antipyretic and anti-inflammatory effects. The invention takes the effect of purging the lung.
Peucedanum root is bitter and pungent in flavor and slightly cold in nature. It enters lung meridian. Has the effects of dispelling pathogenic wind, clearing away heat, lowering qi and eliminating phlegm. Modern pharmacological research finds that the peucedanum praeruptorum has the effects of spasmolysis, phlegm elimination and anti-inflammation. The invention takes the effects of dispersing wind and clearing heat, and descending qi and eliminating phlegm.
Children experience wind evil, lung qi is not dispersed, spleen is often insufficient, food is not eaten normally, stagnation is accumulated to dissipate heat, exogenous pathogenic factors are combined with endogenous pathogenic factors, liquid is refined into phlegm, and the phlegm follows the adverse flow of qi, so cough is abundant in phlegm, thick and sticky and difficult to expectorate; ascending qi and fire, and interior heat fumigating, the symptoms of red face, red lips, dry mouth, thirst, restlessness, red tongue with yellow coating, slippery and rapid pulse, and purple finger print. For it is indicated for clearing heat and dispersing lung qi, relieving cough and eliminating phlegm.
The concretio silicea bambusae disclosed by the invention is special for heart, is formed by the essence qi of bamboo, and has slight effect on bamboo juice, so that phlegm can be removed and orifices can be benefited, but the concretio silicea bambusae has the effects of removing wind, removing heat, cooling heart, treating wind-heat phlegm surge of infantile convulsion, and has moderate property and no cold and slippery trouble compared with the bamboo juice; the composition is matched with the products of white mulberry root-bark, whiteflower hogfennel root, baical skullcap root, platycodon root, Indian buead, tangerine peel, immature bitter orange, weeping forsythia capsule and officinal magnolia bark for clearing heat and descending lung, relieving cough and descending adverse qi, strengthening spleen and eliminating stagnation, and has the functions of clearing heat and descending lung, relieving cough and eliminating phlegm.
The invention is guided by medical theories such as 'orthodox surgery', 'essential formula for surgical heart method' and the like, has reasonable compatibility, achieves better effect of treating infantile fever and cough through research in the direction of pure traditional Chinese medicines and matching relationship and proportion relationship of all raw materials, simultaneously effectively controls body temperature, can prevent and reduce risk of convulsion, and effectively improves the treatment and prevention effect of the traditional Chinese medicines.
In some embodiments, the composition comprises, by weight, 3-6 parts of concretio silicea bambusae, 5-8 parts of platycodon grandiflorum, 5-8 parts of immature bitter orange, 5-8 parts of poria cocos, 5-8 parts of scutellaria baicalensis, 5-8 parts of mangnolia officinalis, 5-8 parts of pericarpium citri reticulatae, 6-8 parts of fructus forsythiae, 6-10 parts of cortex mori radicis and 6-10 parts of radix peucedani.
In some embodiments, the composition comprises, by weight, 3-6 parts of concretio silicea bambusae, 5-6 parts of platycodon grandiflorum, 5-6 parts of immature bitter orange, 5-6 parts of poria cocos, 5-6 parts of scutellaria baicalensis, 5-6 parts of mangnolia officinalis, 5-6 parts of pericarpium citri reticulatae, 6-7 parts of fructus forsythiae, 6-8 parts of cortex mori radicis and 6-8 parts of radix peucedani.
In different embodiments, the formula of the traditional Chinese medicine composition for treating infantile fever and cough can be as follows:
3 parts of concretio silicea bambusae, 5 parts of platycodon grandiflorum, 5 parts of immature bitter orange, 5 parts of poria cocos, 5 parts of scutellaria baicalensis, 5 parts of mangnolia officinalis, 5 parts of pericarpium citri reticulatae, 6 parts of fructus forsythiae, 6 parts of cortex mori radicis and 6 parts of radix peucedani;
4 parts of concretio silicea bambusae, 6 parts of platycodon grandiflorum, 6 parts of immature bitter orange, 6 parts of poria cocos, 6 parts of scutellaria baicalensis, 6 parts of mangnolia officinalis, 6 parts of pericarpium citri reticulatae, 7 parts of fructus forsythiae, 8 parts of cortex mori radicis and 8 parts of radix peucedani;
6 parts of tabasheer, 10 parts of platycodon grandiflorum, 10 parts of immature bitter orange, 10 parts of poria cocos, 10 parts of scutellaria baicalensis, 10 parts of mangnolia officinalis, 10 parts of pericarpium citri reticulatae, 10 parts of fructus forsythiae, 10 parts of cortex mori and 10 parts of radix peucedani;
5 parts of concretio silicea bambusae, 8 parts of platycodon grandiflorum, 8 parts of immature bitter orange, 8 parts of poria cocos, 8 parts of scutellaria baicalensis, 8 parts of mangnolia officinalis, 8 parts of pericarpium citri reticulatae, 8 parts of fructus forsythiae, 8 parts of cortex mori radicis and 8 parts of radix peucedani; and so on.
The liquid medicine prepared by the traditional Chinese medicines with the formulas has no obvious effect difference.
The traditional Chinese medicine composition provided by the invention can be prepared into different pharmaceutical dosage forms according to the actual convenience of taking.
The traditional Chinese medicine composition provided by the invention also comprises auxiliary materials for preparing the traditional Chinese medicine composition into various pharmaceutical dosage forms.
Further, the dosage forms comprise decoction, granules, tablets, pills, drink tablets and capsules.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
the effective raw materials are decocted with water to obtain liquid medicine.
The method is simple and convenient to prepare and easy for industrial production.
Further, the effective raw materials are firstly soaked in water for 30-40 minutes and then decocted.
Furthermore, the number of times of decoction is 1-2.
Further, the number of times of decoction is 2, and the steps are as follows:
boiling with strong fire, then decocting with slow fire for 20-30 minutes, and filtering to obtain a first filtrate;
adding water into the filter residue, boiling with strong fire, decocting with slow fire for 15-20 minutes, and filtering to obtain a second filtrate;
and combining the first filtrate and the second filtrate to obtain the liquid medicine.
The strong fire refers to a strong and urgent fire, i.e. a strong fire. Slow fire refers to a small and slow fire when decocting herbs, i.e. a small fire. The effective components in the Chinese herbal medicines are fully dissolved in the liquid medicine when the medicine is decocted firstly with strong fire and then with slow fire.
Further, the volume of the first filtrate is 180 ml and 250 ml in terms of grams of the effective raw materials;
the volume of the second filtrate was 180 ml and 250 ml.
In the invention, when water is added for the first time, the water surface is 2-3cm higher than the medicine; adding water into the residue, and slightly increasing the water level to obtain the final product.
In the invention, the common traditional Chinese medicine earthen pot is adopted for decoction, and of course, other containers can be adopted for processing.
Compared with the prior art, the invention has the beneficial effects that:
(1) the traditional Chinese medicine composition for treating infantile fever and cough provided by the invention has the advantages that the middle-aged tabasheer is special for heart, the tabasheer can remove wind and remove heat to cool the heart, and the wind-heat phlegm surge of infantile convulsion is treated, so that the nature is moderate, and the children are not suffered from cold and slippery; the composition is matched with the products of white mulberry root-bark, whiteflower hogfennel root, baical skullcap root, platycodon root, Indian buead, tangerine peel, immature bitter orange, weeping forsythia capsule and officinal magnolia bark for clearing heat and descending lung, relieving cough and descending adverse qi, strengthening spleen and eliminating stagnation, and has the functions of clearing heat and descending lung, relieving cough and eliminating phlegm.
(2) The traditional Chinese medicine composition provided by the invention can be prepared into different pharmaceutical dosage forms according to requirements so as to be convenient to take.
(3) The invention also provides a preparation method of the traditional Chinese medicine composition for treating infantile fever and cough, the liquid medicine prepared by the method has excellent curative effect, and the preparation method is simple, convenient and feasible, and is easy for industrialized production.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Example 1
A traditional Chinese medicine composition for treating infantile fever and cough is prepared from the following raw materials in parts by weight:
3 g of concretio silicea bambusae, 5 g of platycodon grandiflorum, 5 g of immature bitter orange, 5 g of poria cocos, 5 g of scutellaria baicalensis, 5 g of mangnolia officinalis, 5 g of pericarpium citri reticulatae, 6 g of fructus forsythiae, 6 g of cortex mori radicis and 6 g of radix peucedani.
And respectively packaging the decoction pieces with the weight, and then mixing and packaging.
When the medicine is used, a patient opens a package, the medicines are mixed and placed in an earthenware pot, clear water is added, the water level is 2-3cm higher than the medicines, the medicines are soaked for 30-40 minutes, the medicines are decocted with strong fire, the water level is changed to be 2-3cm higher than the medicines, the medicines are decocted for 20-30 minutes, about 200ml of medicine liquid is decocted, the medicine liquid is combed out, medicine residues are left in the pot, clear water is added into the pot, the medicine residues are slightly higher than the water level, the medicines are decocted with strong fire until the pot is opened, the medicines are decocted with slow fire for 15-20 minutes, about 200ml of medicine liquid is decocted, the medicine liquid is combed out, the medicine liquid and the first decocted medicine are uniformly mixed, the medicine is taken warmly (the medicine can be heated.
Example 2
A traditional Chinese medicine composition for treating infantile fever and cough is prepared from the following raw materials in parts by weight:
6 g of concretio silicea bambusae, 10 g of platycodon grandiflorum, 10 g of immature bitter orange, 10 g of poria cocos, 10 g of scutellaria baicalensis, 10 g of mangnolia officinalis, 10 g of pericarpium citri reticulatae, 10 g of fructus forsythiae, 10 g of cortex mori radicis and 10 g of radix peucedani.
And respectively packaging the decoction pieces with the weight, and then mixing and packaging.
When the medicine is used, a patient opens a package, the medicines are mixed and placed in an earthenware pot, clear water is added, the water level is 2-3cm higher than the medicines, the medicines are soaked for 30-40 minutes, the medicines are decocted with strong fire, the water level is changed to be 2-3cm higher than the medicines, the medicines are decocted for 20-30 minutes, about 200ml of medicine liquid is decocted, the medicine liquid is combed out, medicine residues are left in the pot, clear water is added into the pot, the medicine residues are slightly higher than the water level, the medicines are decocted with strong fire until the pot is opened, the medicines are decocted with slow fire for 15-20 minutes, about 200ml of medicine liquid is decocted, the medicine liquid is combed out, the medicine liquid and the first decocted medicine are uniformly mixed, the medicine is taken warmly (the medicine can be heated.
Experimental example 1
1. Acute toxicity test
The traditional Chinese medicine composition for treating infantile fever and cough in the embodiment is subjected to an acute toxicity test, and the maximum tolerance test is carried out under the condition that the acute toxicity of animals is not detected. 50ml/kg of a decoction of a traditional Chinese medicine composition for treating fever and cough in children is taken twice a day by a Kunming mouse through the stomach, the continuous observation is carried out for 2 weeks, the toxicity performance of the animals after the administration is recorded, and the result shows that the animals are in a quiet state within 2 hours after the administration, and the food intake, the activity condition, the hair color, the defecation condition and other poisoning phenomena caused by the medicine are not seen. None of the animals tested died. The dosage is about 20 times the amount ingested by humans.
The embodiment of the traditional Chinese medicine composition for treating infantile fever and cough is safe and reliable when being taken in a short term within the dosage, and the fact that the clinical planned dose of a human is safe and reliable when being taken in the short term is inferred.
2. Long term toxicity test
The traditional Chinese medicine composition for treating the infantile fever and cough in the embodiment is subjected to a long-term toxicity test, the oral treatment course of the traditional Chinese medicine composition for treating the infantile fever and cough is 3 to 7 days, a long-term toxicity test of 2-week rat gavage administration is carried out, 3 days, 7 days, 2 weeks of administration and 2 weeks after drug withdrawal are respectively subjected to various tests of hematology, hematology and biochemistry and the like, and the result of the test has no obvious toxic reaction compared with that of a water control group.
Wherein the high dose group: 50ml/kg, about 20 times the intake of human; the medium dose group: 25ml/kg, about 10 times the human intake; low dose group: 12.5ml/kg, which is about 5 times the amount ingested by humans.
The test result shows that the animal is safe when the composition is administrated to animals according to the dosage within the administration period (within 14 days), and delayed toxic reaction is not found after the administration is stopped, and the result indicates that the pharmaceutical composition has a large safe range of the administration dosage and a long safe administration period.
Experimental example 2
In order to show the clinical application effect of the invention, the invention is proved by clinical tests that: the composition of example 1 and example 2 was tested for efficacy in children of different ages and sexes for a total of 200 patients, and 100 patients of example 1 and example 2 were tested for efficacy in random cases, and the efficacy of example 1 and example 2 was not significantly different, and the total efficacy was calculated to be 93%.
The specific clinical examples are as follows:
example 1: li Shi, female, 5 years old, 1 month and 12 days in 2017. The main complaints are: fever with cough for 1 day. The following symptoms are marked: fever, a body temperature of 38.2 ℃, cough, profuse sputum, sticky texture, difficult cough, poor appetite, dry stool, yellow urine, red tongue, alternate white and yellow coating and smooth and rapid pulse. The history of hyperpyrexia and infantile convulsion. For example 1, the preparation is administered four times a day, 100ml each time, and the body temperature is gradually reduced to 37.5-37.8 deg.C; the medicine is taken four times the next day, each time 100ml, and the body temperature is gradually reduced to 37-37.3 deg.C; the medicine is taken for four times in the third day, each time is 100ml, the body temperature is gradually reduced to below 37 ℃, and the amount of phlegm is reduced; the medicine is taken three times a day from the fourth day to the seventh day, 100ml of the medicine is taken each time, the body temperature is normal, the cough is gradually relieved, the sputum amount is gradually reduced, and the patient can be cured after eating the medicine as usual.
Example 2: in summer, men are 3 years old and are treated in 2017 in 1 month and 16 days. The main complaints are: fever occurred for 2 days. The following symptoms are marked: fever, body temperature 38.5 ℃, flushed face, coarse breath, cough with heavy voice, anorexia, vomiting once, stomach contents, phlegm and saliva, anorexia, stool, yellow urine, red tongue, white and thick coating, and smooth and rapid pulse. For example 1, the preparation is administered four times a day, 50ml each time, and the body temperature is gradually reduced to 38-38.2 deg.C; the composition is taken four times the next day, each time at 100ml, the body temperature gradually decreases to 37.5-37.8 deg.C, and emesis is once for phlegm and saliva; taken four times every day, each time 100ml, the body temperature gradually decreases to below 37-37.2 deg.C, the face is red, the qi is coarse, and the pharyngalgia is improved; the medicine is taken for four times in the fourth day, 50ml of the medicine is taken each time, the body temperature is gradually reduced to below 37 ℃, and the cough sound weight is improved; the medicine is continuously taken for the seventh day, 50ml of the medicine is taken three times a day, the body temperature is normal, all symptoms are improved, and the patients are cured after eating the medicine as usual.
Example 3: zhangqi, male, 9 years old, 2 months and 13 days in 2017. The main complaints are: fever with cough for 2 days. The following symptoms are marked: fever, body temperature 38.1 ℃, cough with heavy voice, phlegm in the throat, sticky phlegm difficult to cough out, poor appetite, slightly dry stool, yellow urine, red tongue with yellow and thick coating, and slippery and rapid pulse. For example 2, the traditional Chinese medicine composition is taken four times a day, 100ml each time, and the body temperature is gradually reduced to 37.5-38 ℃; the medicine is taken four times the next day, each time 100ml, and the body temperature is gradually reduced to 37-37.5 deg.C; the medicine is taken for four times in the third day, each time is 100ml, the body temperature is gradually reduced to normal, and cough and expectoration are relieved; the medicine is taken three times in the fourth day, each time is 100ml, the body temperature is normal, cough and expectoration are further improved, and defecate is smooth; the traditional Chinese medicine composition is taken to the seventh day, three times a day, 100ml each time, normal body temperature, slight cough, light diet, improvement of various symptoms, and recovery after frequent diet.
Example 4: when waiting for a certain time, men are 2 and half years old, and the doctor is seen in 2017, 2 months and 27 days. The main complaints are: fever occurred for 1 day. The following symptoms are marked: fever, body temperature 37.8 ℃, cough with heavy voice, dry stool, normal urine, red tongue with yellow coating, and slippery and rapid pulse. For example 1, the medicine is taken four times a day, 50ml each time, and the body temperature is gradually reduced to 37.2-37.5 ℃; the medicine is taken four times the next day, each time 50ml, and the body temperature fluctuation is 37.2-37.5 deg.C; the medicine is taken for four times in the third day, 50ml each time, and the cough still exists when the body temperature fluctuation is about 37 ℃; the medicine is taken four times on the fourth day, 50ml of the medicine is taken each time, and the body temperature returns to normal; the cough and the heaviness symptom are obviously improved when the medicine is taken for the sixth day and taken for three times every day, 50ml of the medicine is taken every time.
Example 5: visit on 2 years old, 3 months and 17 days in 2018 for Han-Zhi-g. The main complaints are: fever with cough for half a day. The following symptoms are marked: fever, body temperature 37.6 ℃, cough with heavy voice, anorexia, constipation, red tongue with yellow coating, and rapid pulse. The history of hyperpyrexia and infantile convulsion. Example 1, the preparation is administered three times a day, 50ml each time, with body temperature fluctuation of 37.4-37.8 deg.C; the medicine is taken four times the next day, 50ml each time, and the body temperature fluctuation is 37.2-37.5 deg.C; taking the medicine for three times in the third day, wherein each time is 50ml, and the body temperature fluctuation is 36.8-37.2 ℃; taking the medicine for three times in the fourth day, wherein the dose is 50ml once, the body temperature is reduced to normal, and cough is occasionally caused; the cough is also improved after taking the medicine twice a day and 50ml once.
Example 6: liu Yi, female, 11 years old, and the doctor visits 4 months and 6 days in 2017. The main complaints are: cough with more sputum for 4 days. The following symptoms are marked: normal body temperature, cough with profuse sputum, sore throat, poor appetite, dry stool, three days of non-movement, yellow urine, red tongue with yellow and thick coating, and smooth and rapid pulse. Example 2, the medicine is taken three times a day, 100ml each time, stool is already gone, and pharyngalgia is relieved; the medicine is taken for five days, two to three times a day, and 100ml of the medicine is taken once, pharyngalgia is cured, cough with excessive phlegm is obviously improved, and defecation is normal and tends to be cured; order to eat light diet, and continue taking two days for further consultation.
Example 7: yang Shi, male, 12 years old, and the physician can see the disease 4-11 days in 2017. The main complaints are: fever with cough and expectoration for 3 days. The following symptoms are marked: the body temperature is 37.4 ℃, cough and expectoration are caused, the sputum is large, the expectoration can be realized, the sputum is yellow, the phlegm can be received, the convenient adjustment can be realized, the tongue is red, the tongue coating is yellow, and the pulse is smooth. For example 2, the medicine is taken three times a day, 100ml is taken each time, the body temperature is gradually normal after the medicine is taken for two days, and the sputum volume is reduced; the medicine is continuously taken for 7 days, two to three times a day, and 100ml of the medicine is taken once, so that cough and expectoration are cured.
Example 8: strictly, women, age 4, visit 8/12 in 2017. The main complaints are: fever occurred for 1 day. The following symptoms are marked: fever, body temperature 38.2 ℃, flushed face, thick breath, phlegm in the throat, poor appetite, dry stool, irregular urine, pale red tongue with white and thick coating, and slippery and rapid pulse. The history of hyperpyrexia and infantile convulsion. Example 1, the composition is administered four times a day, 50ml each time, with body temperature fluctuation at 38-38.2 deg.C; the medicine is taken for four times in the second day, each time is 100ml, the body temperature is gradually reduced to about 37.8 ℃, and cough is caused; the medicine is taken for four times in the third day, each time is 100ml, the body temperature gradually decreases to normal, and the amount of phlegm decreases; the medicine is taken for seven days continuously, 50ml of the medicine is taken three times a day, the body temperature is normal, cough and expectoration disappear, and the patient can be cured after eating the medicine as usual.
Example 9: wangzhi, man, 7 years old, in 2018, and visit 5 months and 10 months. The main complaints are: fever with cough and expectoration for 2 days. The following symptoms are marked: fever, body temperature 37.3 ℃, cough with heavy voice, more sputum, yellow and sticky sputum, poor appetite, stool going for two days, yellow and scanty urine, red tongue, white and greasy coating, and slippery pulse. Example 2, three times a day with 100ml each time, with body temperature fluctuation at 37.2-37.5 deg.C; three times per day with 100ml each time, and body temperature fluctuation at 36.8-37.3 deg.C; taken three times in the third day, each time is 100ml, the body temperature fluctuation is 36.5-37 ℃, the cough sound weight is obviously reduced, and the sputum volume is reduced; on the fourth to seventh days, 100ml twice a day, the symptoms are improved by ordering a light diet.
Example 10: visit some womb and female in 10 years, in 2018, 10 months and 9 days. The main complaints are: fever occurred for 2 days. The following symptoms are marked: fever, body temperature 37.9 ℃, flushed face, thick breath, dry stool, yellow and short urine, red tongue with yellow and thick coating, and slippery and rapid pulse. The history of hyperpyrexia and infantile convulsion. Example 2, the composition is taken four times a day, 100ml each time, and the body temperature fluctuation is 37.6-38 ℃; the medicine is taken for four times in the second day, each time is 100ml, and the body temperature is gradually reduced to about 37.5 ℃; three times in the third day, each time 100ml, the body temperature is gradually reduced to 36.8-37.3 ℃; the medicine is taken three times on the fourth day, 100ml is taken once, and the body temperature is normal; taken twice a fifth day, once 100 ml. Normal body temperature, recovery and stopping taking medicine.
While particular embodiments of the present invention have been illustrated and described, it would be obvious that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (8)

1. A traditional Chinese medicine composition for treating infantile fever and cough is characterized by comprising the following effective raw materials: by weight, 3-6 parts of tabasheer, 5-10 parts of platycodon grandiflorum, 5-10 parts of immature bitter orange, 5-10 parts of poria cocos, 5-10 parts of scutellaria baicalensis, 5-10 parts of mangnolia officinalis, 5-10 parts of pericarpium citri reticulatae, 6-10 parts of fructus forsythiae, 6-10 parts of cortex mori radicis and 6-10 parts of radix peucedani.
2. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 3-6 parts of tabasheer, 5-8 parts of platycodon grandiflorum, 5-8 parts of immature bitter orange, 5-8 parts of poria cocos, 5-8 parts of scutellaria baicalensis, 5-8 parts of mangnolia officinalis, 5-8 parts of pericarpium citri reticulatae, 6-8 parts of fructus forsythiae, 6-10 parts of cortex mori and 6-10 parts of radix peucedani.
3. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition comprises, by weight, 3-6 parts of tabasheer, 5-6 parts of platycodon grandiflorum, 5-6 parts of immature bitter orange, 5-6 parts of poria cocos, 5-6 parts of scutellaria baicalensis, 5-6 parts of mangnolia officinalis, 5-6 parts of pericarpium citri reticulatae, 6-7 parts of fructus forsythiae, 6-8 parts of cortex mori and 6-8 parts of radix peucedani.
4. The composition of any one of claims 1-3, further comprising an adjuvant for making the composition into pharmaceutical dosage forms, including decoction, granule, tablet, pill, and capsule.
5. A method for preparing the Chinese medicinal composition of any one of claims 1 to 3, which comprises the following steps:
the effective raw materials are decocted with water to obtain liquid medicine.
6. The preparation method according to claim 5, wherein the effective ingredients are first soaked in water for 30-40 minutes and then decocted.
7. The method of claim 6, wherein the number of times of decoction is 1-2.
8. The method of claim 6, wherein the number of times of decoction is 2, and the steps are as follows:
boiling with strong fire, then decocting with slow fire for 20-30 minutes, and filtering to obtain a first filtrate;
adding water into the filter residue, boiling with strong fire, decocting with slow fire for 15-20 minutes, and filtering to obtain a second filtrate;
and combining the first filtrate and the second filtrate to obtain the liquid medicine.
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