CN109432266A - Application of the Chinese medicine in preparation anti-hypoxia medicament - Google Patents
Application of the Chinese medicine in preparation anti-hypoxia medicament Download PDFInfo
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- CN109432266A CN109432266A CN201811539283.1A CN201811539283A CN109432266A CN 109432266 A CN109432266 A CN 109432266A CN 201811539283 A CN201811539283 A CN 201811539283A CN 109432266 A CN109432266 A CN 109432266A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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Abstract
The present invention relates to the field of Chinese medicines, specifically, providing a kind of application of Chinese medicine in preparation anti-hypoxia medicament.Chinese medicine provided by the invention includes dog kidney, and deer's sinew takes the lead mouth and removes pawl sparrow meat, donkey kidney, dried shrimps, pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, radix achyranthis bidentatae, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, charred CORTEX EUCOMMIAE, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, salt fry semen astragali complanati, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Semen Cuscutae, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae.The drug has good effect on the hypoxia-bearing capability for promoting body, it is a discovery of the invention that the reduction of the oxygen-resistant ability as caused by body medication, Chinese medicine tool is significantly improved effect.The drug for improving resist oxygen lack be can be used as clinical practice.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of application of Chinese medicine in preparation anti-hypoxia medicament.
Background technique
" hippocampus Bushen Pills " are the prescription of China's Gu doctor, have the effect of enriching yin and nourishing kidney, strong brain tonic, decline for body
Weak, qi-blood deficiency, deficiency of kidney-QI is lean and haggard, heartbeat shortness of breath, soreness of waist and ache in legs, the illnesss such as amnesia void asthma.Currently, " hippocampus kidney tonifying
Ball " is mainly used for above-mentioned illness, if there are also other indications and therapy field not to know, i.e., there is no obtain for hippocampus Bushen Pills
It is utilized to sufficient.
In view of this, the present invention is specifically proposed.
Summary of the invention
The purpose of the present invention is to provide a kind of application of Chinese medicine in preparation anti-hypoxia medicament.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
A kind of application of Chinese medicine in preparation anti-hypoxia medicament；
Wherein, the raw material of the Chinese medicine includes: dog kidney, deer's sinew, takes the lead mouth and removes pawl sparrow meat, donkey kidney, dried shrimps,
Pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel,
Radix achyranthis bidentatae, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, charred CORTEX EUCOMMIAE, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, salt are fried husky
Yuan Zi, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Semen Cuscutae, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae.
Further, the dosage of the Chinese medicine is 1.1~2.2g/kg/ days.
Further, application of the Chinese medicine in the drug that preparation improves anoxic, the anoxic are swashed due to beta receptor
Dynamic agent causes；
Preferably, the beta receptor agonist includes isoprel, dobutamine or Dopexamine, preferably different
Third adrenaline.
Further, according to parts by weight, it dog kidney 1500-2500 parts, 20-80 parts of deer's sinew, 500-1200 parts of pilose antler, takes the lead
Mouth is gone to go 5500-9500 parts of pawl sparrow meat, 750-1100 parts of donkey kidney, 300-900 parts of dried shrimps, 100-1500 parts of hippocampus, extra large maggot
200-1000 parts, leopard bone 10-100 parts processed and gekko 100-850 parts.
Further, according to parts by weight, Radix Astragali 100-1200 parts, 300-1200 parts of ginseng, 300-1500 parts of Radix Angelicae Sinensis, meat
Osmanthus 200-750 parts, 300-1200 parts of radix achyranthis bidentatae, 3000-6000 parts of Rehmannia glutinosa, 3500-7000 parts of radix aconiti lateralis preparata, Fructus Caryophylli 1500-
4500 parts, 950-1800 parts and 700-1700 parts of salt psoralea corylifolia of salt fennel.
Further, according to parts by weight, Radix Codonopsis 1200-3000 parts, 100-1500 parts of rhizoma cibotii, 500-1500 parts of Poria cocos,
950-2500 parts of Chinese yam, 900-1700 parts of walnut kernel, 300-1200 parts of charred CORTEX EUCOMMIAE, 3000-6500 parts of wine Herba Cistanches, make excessive sheep
900-3500 parts of the leaves of pulse plants and salt fry semen astragali complanati 900-1700 parts.
Further, according to parts by weight, Radix Glycyrrhizae 100-900 parts, 1000-3000 parts of raspberry, Semen Cuscutae 600-1700
Part, 500-1500 part of fructus lycii, 250-1500 parts of calcined Dragon's bone, 300-1200 parts of wine Fructus Schisandrae (processed) and wine Fructus Corni (processed) 500-1800
Part.
Further, according to parts by weight, 1875 parts of dog kidney, 750 parts of pilose antler, take the lead mouth and go the fresh sparrow of pawl by 40 parts of deer's sinew
7500 parts of meat, 930 parts of donkey kidney, 500 parts of dried shrimps, 75 parts of hippocampus 3,375 parts of extra large maggot, 40 parts of leopard bone processed, 240 parts of gekko, Radix Astragali
It 625 parts, 750 parts of ginseng, 1000 parts of Radix Angelicae Sinensis, 375 parts of cortex cinnamomi, 750 parts of radix achyranthis bidentatae, 2500 parts of Fructus Caryophylli, 5000 parts of Rehmannia glutinosa, makes attached
5000 parts of son, 1250 parts of salt fennel, 1250 parts of salt psoralea corylifolia, 1875 parts of Radix Codonopsis, 375 parts of rhizoma cibotii, 750 parts of Poria cocos, Chinese yam
1500 parts, 1250 parts of walnut kernel, 750 parts of charred CORTEX EUCOMMIAE, 5000 parts of wine Herba Cistanches, 2000 parts of Herba Epimedii processed, salt fries semen astragali complanati
1250 parts, 375 portions of Radix Glycyrrhizae, 2000 parts of raspberry, 1250 parts of Semen Cuscutae, 750 parts of fructus lycii, 625 parts of wine Fructus Schisandrae (processed)s of calcined Dragon's bone
750 parts and 750 parts of wine Fructus Corni (processed).
Further, the Chinese medicine is prepared by the following method to obtain: it is former that water mentions condensed cream, wine powder and 29 tastes
The mixed-powder mixing pill of material, is coated with coating agent, obtains the Chinese medicine；
The water mentions condensed cream to boil 2-3 by Rehmannia glutinosa and before taking the lead the water that mouth goes pawl sparrow meat to add 5-10 times of weight
It is secondary, it boils every time 2-5 hours, merges decocting liquid, filtration, filtrate is condensed into the water concentrate that 45-55 DEG C of relative density is 1.1-1.5
Contracting cream；
The wine powder is to add 3000-5000 times of weight yellow rice wine to set in container donkey kidney, dog kidney, deer's sinew and dried shrimps,
Sealing is steamed until yellow rice wine is exhausted by medicinal material, is taken out, be dry, pulverize sieving and obtain；
The mixed-powder of the 29 taste raw material includes: pilose antler, hippocampus, extra large maggot, gekko, radix achyranthis bidentatae, ginseng, Radix Astragali, Radix Codonopsis, Fu
Siberian cocklebur, Chinese yam, rhizoma cibotii, Radix Angelicae Sinensis, cortex cinnamomi, walnut kernel, Semen Cuscutae, Fructus Caryophylli, radix aconiti lateralis preparata, leopard bone processed, raspberry, fructus lycii, salt system
Fennel, salt psoralea corylifolia, wine Herba Cistanches, Herba Epimedii processed, salt fry semen astragali complanati, wine Fructus Schisandrae (processed), wine Fructus Corni (processed), calcined Dragon's bone and
The mixed-powder of Radix Glycyrrhizae；
The coating agent is to be crushed into powder charred CORTEX EUCOMMIAE, crosses 120 meshes and obtains.
Further, the mixed-powder of the 29 taste raw material, wine powder and water propose condensed cream mixing, and proper honey is added
And water, then the step of carrying out pill.
Compared with prior art, the invention has the benefit that
Chinese medicine provided by the invention includes dog kidney, and deer's sinew takes the lead mouth and goes pawl sparrow meat, donkey kidney, dried shrimps, deer
Young pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, ox
Knee, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, charred CORTEX EUCOMMIAE, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, the garden Yan Chaosha
Son, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Semen Cuscutae, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae, as raising anti-hypoxia medicament
With significant curative effect.The drug has good effect on the hypoxia-bearing capability for promoting body, it is a discovery of the invention that due to machine
The reduction of oxygen-resistant ability caused by body medication, Chinese medicine tool are significantly improved effect.It can be used as and improve resist oxygen lack
Drug is used for clinical practice, to the drug make full use of and exploitation plays significance, and give research direction.Together
When, which derives from crude drug, is free from side effects, safely and effectively.
Detailed description of the invention
Fig. 1 is the influence that Chinese medicine causes the anoxia in mice time-to-live to isoprel in the embodiment of the present invention 2.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.
A kind of application of Chinese medicine in preparation anti-hypoxia medicament；Wherein, the raw material of Chinese medicine includes: dog kidney, deer
Muscle takes the lead mouth and removes pawl sparrow meat, donkey kidney, dried shrimps, pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis,
Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, radix achyranthis bidentatae, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, charred CORTEX EUCOMMIAE, dog
Ridge, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, salt fry semen astragali complanati, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Semen Cuscutae, wine system
Fructus Corni, calcined Dragon's bone and Radix Glycyrrhizae.
The drug has good effect on the hypoxia-bearing capability for promoting body, it is a discovery of the invention that due to body medication
The reduction of caused oxygen-resistant ability, Chinese medicine tool are significantly improved effect.It can be used as the drug use for improving resist oxygen lack
In clinical practice, to the drug make full use of and exploitation plays significance, and give research direction.Meanwhile in this
Medicine medicament sources are free from side effects in crude drug, safely and effectively.
In some embodiments of the present invention, the dosage of Chinese medicine is 1.1~2.2g/kg/ days.To body under the dosage
Oxygen resistence have good promotion, can be effectively improved due to medication generate body hypoxic conditions.
In some embodiments of the present invention, application of the Chinese medicine in the drug that preparation improves anoxic, wherein anoxic
Since beta receptor agonist causes.Beta receptor agonist has for treating and preventing the respiratory disorder such as asthma, bronchitis
Certain side effect, such as the hypoxia-bearing capability decline of body, the Chinese medicine can be effectively improved these side effects.
In certain embodiments of the present invention, beta receptor agonist includes isoprel, dobutamine or more trainings
Sha Ming, preferably isoprel.
In some embodiments of the present invention, according to parts by weight, 1500-2500 parts of dog kidney, 20-80 parts of deer's sinew, pilose antler
It 500-1200 parts, takes the lead mouth and goes 5500-9500 parts of pawl sparrow meat, 750-1100 parts of donkey kidney, 300-900 parts of dried shrimps, hippocampus
100-1500 parts, extra large maggot 200-1000 parts, leopard bone 10-100 parts processed and gekko 100-850 parts.It should be noted that by weight
Number meter, typical but non-limiting dog kidney is 1500 parts, 1700 parts, 1900 parts, 2000 parts, 2200 parts or 2500 parts；Deer's sinew allusion quotation
Type but it is unrestricted be 20 parts, 40 parts, 60 parts or 80 parts；It is 500 parts that pilose antler is typical but non-limiting, 700 parts, 900 parts,
1000 parts or 1200 parts；Take the lead mouth go pawl sparrow meat it is typical but non-limiting be 5500 parts, 6500 parts, 7500 parts, 8500
Part or 9500 parts；Typical but non-limiting donkey kidney is 750 parts, 850 parts, 950 parts, 1050 parts or 1100 parts；Dried shrimps are typical
But unrestricted is 300 parts, 500 parts, 700 parts or 900 parts；It is 100 parts that hippocampus is typical but non-limiting, 300 parts, 500
Part, 700 parts, 900 parts, 1100 parts, 1400 parts or 1500 parts；It is 200 parts that extra large maggot is typical but non-limiting, 400 parts, 600 parts,
800 parts or 1000 parts；Typical but non-limiting leopard bone processed is 10 parts, 30 parts, 50 parts, 70 parts, 90 parts or 100 parts；Gekko allusion quotation
Type but it is unrestricted be 100 parts, 300 parts, 500 parts, 700 parts or 850 parts.
In certain embodiments of the present invention, according to parts by weight, Radix Astragali 100-1200 parts, 300-1200 parts of ginseng,
300-1500 parts of Radix Angelicae Sinensis, 200-750 parts of cortex cinnamomi, 300-1200 parts of radix achyranthis bidentatae, 1500-4500 parts of Fructus Caryophylli, Rehmannia glutinosa 3000-6000
Part, 3500-7000 parts of radix aconiti lateralis preparata, 950-1800 parts of salt fennel and 700-1700 parts of salt psoralea corylifolia.It should be noted that
Typical but non-limiting Radix Astragali is 100 parts, 300 parts, 500 parts, 700 parts, 900 parts, 1000 parts or 1200 parts；Ginseng it is typical but
Unrestricted is 300 parts, 500 parts, 700 parts, 900 parts, 1000 parts or 1200 parts；Typical but non-limiting Radix Angelicae Sinensis is 300
Part, 500 parts, 700 parts, 900 parts, 1000 parts, 1200 parts or 1500 parts；It is 200 parts that cortex cinnamomi is typical but non-limiting, 400 parts,
600 parts or 750 parts；Typical but non-limiting Fructus Caryophylli is 1500 parts, 2500 parts, 3500 parts or 4500 parts；Radix achyranthis bidentatae it is typical but
Unrestricted is 300 parts, 500 parts, 700 parts, 900 parts, 1000 parts or 1200 parts；Rehmannia glutinosa is typical but non-limiting to be
3000 parts, 4000 parts, 5000 parts or 6000 parts；It is 3500 parts that radix aconiti lateralis preparata is typical but non-limiting, 4500 parts, 5500 parts,
6500 parts or 7500 parts；Salt fennel is typical but non-limiting be 950 parts, 1050 parts, 1350 parts, 1550 parts, 1750 parts or
1800 parts；Typical but non-limiting salt psoralea corylifolia is 700 parts, 900 parts, 1100 parts, 1300 parts, 1500 parts or 1700 parts.
In certain embodiments of the present invention, according to parts by weight, Radix Codonopsis 1200-3000 parts, 100-1500 parts of rhizoma cibotii,
500-1500 parts of Poria cocos, 950-2500 parts of Chinese yam, 900-1700 parts of walnut kernel, 300-1200 parts of charred CORTEX EUCOMMIAE, wine Herba Cistanches
3000-6500 parts, Herba Epimedii 900-3500 parts processed and semen astragali complanati 900-1700 parts of salt stir-fry.It should be noted that Radix Codonopsis it is typical but
It is unrestricted be 1200 parts, 1400 parts, 1600 parts, 1800 parts, 2000 parts, 2200 parts, 2400 parts, 2600 parts, 2800 parts or
3000 parts；Rhizoma cibotii is typical but non-limiting be 100 parts, 300 parts, 500 parts, 700 parts, 900 parts, 1100 parts, 1300 parts or
1500 parts；Typical but non-limiting Poria cocos is 500 parts, 700 parts, 900 parts, 1100 parts, 1300 parts or 1500 parts；Chinese yam is typical
But unrestricted is 950 parts, 1150 parts, 1350 parts, 1550 parts, 1750 parts, 1950 parts, 2150 parts, 2350 parts or 2500 parts；
Typical but non-limiting walnut kernel is 900 parts, 1100 parts, 1300 parts, 1500 parts or 1700 parts；Charred CORTEX EUCOMMIAE is typical but unrestricted
Property is 300 parts, 500 parts, 700 parts, 900 parts, 1000 parts or 1200 parts；Typical but non-limiting wine Herba Cistanches are 3000
Part, 4000 parts, 5000 parts, 6000 parts or 6500 parts；It is 900 parts that Herba Epimedii processed is typical but non-limiting, 1100 parts, 2100
Part, 3100 parts or 3500 parts；Salt fry semen astragali complanati it is typical but non-limiting be 900 parts, 1100 parts, 1300 parts, 1500 parts or
1700 parts.
In certain embodiments of the present invention, according to parts by weight, Radix Glycyrrhizae 100-900 parts, raspberry 1000-3000
Part, 600-1700 part of Semen Cuscutae, 500-1500 parts of fructus lycii, 250-1500 parts of calcined Dragon's bone, 300-1200 parts of wine Fructus Schisandrae (processed) with
500-1800 parts of wine Fructus Corni (processed).It should be noted that Radix Glycyrrhizae is typical but non-limiting is 100 parts, 300 parts, 500 parts, 700
Part or 900 parts；Typical but non-limiting raspberry is 1000 parts, 2000 parts or 3000 parts；Semen Cuscutae is typical but non-limiting
It is 600 parts, 800 parts, 1000 parts, 1200 parts, 1400 parts, 1600 parts or 1700 parts；Fructus lycii is typical but non-limiting to be
500 parts, 700 parts, 900 parts, 1100 parts, 1300 parts or 1500 parts；It is 250 parts that calcined Dragon's bone is typical but non-limiting, 550 parts,
850 parts, 1150 parts, 1350 parts or 1500 parts；It is 300 parts that wine Fructus Schisandrae (processed) is typical but non-limiting, 500 parts, 700 parts, 900
Part, 1000 parts or 1200 parts；It is 500 parts that wine Fructus Corni (processed) is typical but non-limiting, 800 parts, 1100 parts, 1400 parts, 1600
Part or 1800 parts.
In the present invention, one is preferably carried out in mode, according to parts by weight, 1875 parts of dog kidney, 40 parts of deer's sinew, pilose antler 750
Part, it takes the lead mouth and goes 7500 parts of pawl sparrow meat, 930 parts of donkey kidney, 500 parts of dried shrimps, 75 parts of hippocampus 3,375 parts of extra large maggot, leopard bone processed
40 parts, 240 parts of gekko, 625 parts of Radix Astragali, 750 parts of ginseng, 1000 parts of Radix Angelicae Sinensis, 375 parts of rhizoma cibotii, 375 parts of cortex cinnamomi, 750 parts of radix achyranthis bidentatae,
1875 parts of Radix Codonopsis, 750 parts of Poria cocos, 1500 parts of Chinese yam, 5000 parts of Rehmannia glutinosa, 5000 parts of radix aconiti lateralis preparata, 2000 parts of raspberry, Fructus Caryophylli
2500 parts, 750 parts of charred CORTEX EUCOMMIAE, 1250 parts of Semen Cuscutae, 1250 parts of salt fennel, 1250 parts of salt psoralea corylifolia, wine Herba Cistanches
5000 parts, 1250 parts of walnut kernel, 2000 parts of Herba Epimedii processed, 1250 parts of semen astragali complanati of salt stir-fry, 750 parts of fructus lycii, wine Fructus Schisandrae (processed) 750
Part, 750 parts of wine Fructus Corni (processed), 625 parts and 375 parts of Radix Glycyrrhizae of calcined Dragon's bone.The Chinese medicine each group distribution ratio is reasonable, and efficacy stability is aobvious
It writes.
The present invention one be preferably carried out in mode, Chinese medicine is prepared by the following method to obtain: water mention condensed cream,
The mixed-powder mixing pill of wine powder and 29 taste raw materials, is coated with coating agent, obtains Chinese medicine,
Wherein, water mentions condensed cream to boil 2-3 by Rehmannia glutinosa and before taking the lead the water that mouth goes pawl sparrow meat to add 5-10 times of weight
It is secondary, it boils every time 2-5 hours, merges decocting liquid, filtration, filtrate is condensed into the water concentrate that 45-55 DEG C of relative density is 1.1-1.5
Contracting cream；
Wine powder is to add 3000-5000 times of weight yellow rice wine to set in container donkey kidney, dog kidney, deer's sinew and dried shrimps, is sealed,
It steams until yellow rice wine is exhausted by medicinal material, takes out, dry, pulverize sieving and obtain；
The mixed-powder of 29 taste raw materials includes: pilose antler, hippocampus, extra large maggot, gekko, radix achyranthis bidentatae, ginseng, Radix Astragali, Radix Codonopsis, Poria cocos,
Chinese yam, rhizoma cibotii, Radix Angelicae Sinensis, walnut kernel, cortex cinnamomi, leopard bone processed, radix aconiti lateralis preparata, Fructus Caryophylli, Semen Cuscutae, raspberry, fructus lycii, salt fennel
Perfume (or spice), salt psoralea corylifolia, wine Herba Cistanches, Herba Epimedii processed, salt fry semen astragali complanati, wine Fructus Schisandrae (processed), wine Fructus Corni (processed), calcined Dragon's bone and sweet
The mixed-powder of grass；
Coating agent is to be crushed into powder charred CORTEX EUCOMMIAE, crosses 120 meshes and obtains.Chinese medicine is prepared by this method, is remained
The effective component of medicinal material, efficacy stability are significant.
In certain embodiments of the present invention, the mixed-powder of 29 taste raw materials, wine powder and water propose condensed cream mixing,
Proper honey and water, then the step of carrying out pill is added.Honey is added and water is conducive to improve the mouthfeel of drug.
Present invention will be further explained by specific examples below, it should be understood, however, that, these embodiments are only
It is used, is but should not be understood as present invention is limited in any form for being described in more detail.
1 Chinese medicine of embodiment and preparation
(a) 750 parts of charred CORTEX EUCOMMIAEs are crushed into powder, it is spare crosses 120 meshes；
(b) 5000 parts of Rehmannia glutinosas and 7500 parts are taken the lead to boil before the water that mouth goes pawl sparrow meat to add 8 times of weight 8 times, every time
It boils 3 hours, merges decocting liquid, filtration, the condensed cream that it is 1.5 in 50 DEG C of relative densities that filtrate, which is condensed into,；
(c) 4000 times of weight yellow rice wine are added to set container 930 parts of donkey kidneys, 1875 parts of dog kidneys, 40 parts of deer's sinews and 500 parts of dried shrimps
Interior, sealing is steamed until yellow rice wine is exhausted by medicinal material, is taken out, be dry, pulverize sieving；
(d) by remaining 29 taste raw material (750 parts of pilose antler, 75 parts of hippocampus 3,375 parts of extra large maggot, 40 parts of leopard bone processed, 240 parts of gekko,
750 parts of ginseng, 625 parts of Radix Astragali, 1000 parts of Radix Angelicae Sinensis, 5000 parts of radix aconiti lateralis preparata, 375 parts of cortex cinnamomi, 2500 parts of Fructus Caryophylli, salt fennel
1250 parts, 750 parts of radix achyranthis bidentatae, 1250 parts of salt psoralea corylifolia, 1875 parts of Radix Codonopsis, 750 parts of Poria cocos, 1500 parts of Chinese yam, 375 parts of rhizoma cibotii,
5000 parts of wine Herba Cistanches, 1250 parts of walnut kernel, 2000 parts of Herba Epimedii processed, 1250 parts of semen astragali complanati of salt stir-fry, 2000 parts of raspberry, Chinese holly
750 parts of matrimony vine, 750 parts of wine Fructus Schisandrae (processed), 1250 parts of Semen Cuscutae, 750 parts of wine Fructus Corni (processed), 625 parts of calcined Dragon's bone and Radix Glycyrrhizae 375
Part) pulverize and sieve；Powder made from step (c) is added, condensed cream made from step (b) is added, proper honey and water, system is added
Ball rushes circle, dry, is coated with step (a) Cortex Eucommiae powdered carbon, polishing, it is dry to get.
Influence of 2 Chinese medicine of embodiment to resist oxygen lack
Anoxia in mice model is caused using injection isoprel.Select healthy Kunming mouse 84, half male and half female, body
Weight (16-18) g, is grouped, every group 12 by weight Stochastic Equilibrium, and experiment sets the different mountain of Normal group, model control group, single nitric acid
Pear ester piece 40mg/kg, guilingji capsules 0.24g/kg, Chinese medicine (0.55,1.1,2.2) tri- dosage groups of g/kg, totally 7 groups.Respectively give
The daily gastric infusion of medicine group 1 time, Normal group give the distilled water of equivalent, and model control group gives corresponding volume 0.5%
CMC-Na, continuous 5 days, administration volume was 20ml/kg.bw.In 1h after the last administration, the physiology of the capacity such as Normal group injection
Isoprenaline hydrochloride 20mg/kg (10mL/kg) is subcutaneously injected in salt water, remaining each group.After 15min, by each group mouse point
It not being put into the 200mL wide-mouth bottle for filling 10g soda lime, 1 mouse of every bottle of placement, bottle stopper is sealed with vaseline, timing immediately,
The survival time under hypoxic condition of record mouse, calculating prolonging survival rate, rate elongation=(when administration group time-to-live-model group survival
Between)/model group time-to-live * 100%, it the results are shown in Table 1, Fig. 1.
1. Chinese medicine of table causes anoxia in mice time-to-live, prolonging survival rate to influence (n=12) isoprel
Compared with Normal group,△△P<0.01；Compared with model group,﹡P < 0.05,**P<0.01；N: number of animals.
Table 1 is as the result is shown: compared with Normal group, model control group the survival time under hypoxic condition significantly shortens, model success.
Compared with model control group, Chinese medicine 1.1,2.2g/kg dosage group can extend the anoxia in mice time-to-live to some extent, mention
It is shown with and mouse hypoxia-bearing capability is remarkably reinforced.Guilingji capsules 0.24g/kg can significantly extend the mouse survival time, positive drug single nitric acid
Soquad effect is similar.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of application of Chinese medicine in preparation anti-hypoxia medicament；
Wherein, the raw material of the Chinese medicine includes: dog kidney, and deer's sinew takes the lead mouth and goes pawl sparrow meat, donkey kidney, dried shrimps, deer
Young pilose antler, hippocampus, extra large maggot, leopard bone processed, gekko, ginseng, Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, radix aconiti lateralis preparata, cortex cinnamomi, Fructus Caryophylli, salt fennel, ox
Knee, salt psoralea corylifolia, Radix Codonopsis, Poria cocos, Chinese yam, charred CORTEX EUCOMMIAE, rhizoma cibotii, wine Herba Cistanches, walnut kernel, Herba Epimedii processed, the garden Yan Chaosha
Son, raspberry, fructus lycii, wine Fructus Schisandrae (processed), Semen Cuscutae, wine Fructus Corni (processed), calcined Dragon's bone and Radix Glycyrrhizae.
2. application according to claim 1, which is characterized in that the dosage of the Chinese medicine is 1.1~2.2g/kg/ days.
3. application according to claim 1, which is characterized in that the Chinese medicine is in the drug that preparation improves anoxic
Using the anoxic is caused due to beta receptor agonist；
Preferably, the beta receptor agonist includes isoprel, dobutamine or Dopexamine, preferably isopropyl kidney
Upper parathyrine.
4. application according to claim 1, which is characterized in that according to parts by weight, 1500-2500 parts of dog kidney, deer's sinew 20-
It 80 parts, 500-1200 parts of pilose antler, takes the lead mouth and goes 5500-9500 parts of pawl sparrow meat, 750-1100 parts of donkey kidney, dried shrimps 300-
900 parts, 100-1500 parts of hippocampus, extra large maggot 200-1000 parts, leopard bone 10-100 parts processed and gekko 100-850 parts.
5. application according to claim 4, which is characterized in that according to parts by weight, 100-1200 parts of Radix Astragali, ginseng 300-
1200 parts, 300-1500 parts of Radix Angelicae Sinensis, 200-750 parts of cortex cinnamomi, 300-1200 parts of radix achyranthis bidentatae, 1500-4500 parts of Fructus Caryophylli, Rehmannia glutinosa
3000-6000 parts, 3500-7000 parts of radix aconiti lateralis preparata, 950-1800 parts and 700-1700 parts of salt psoralea corylifolia of salt fennel.
6. application according to claim 5, which is characterized in that according to parts by weight, 1200-3000 parts of Radix Codonopsis, rhizoma cibotii
100-1500 parts, 500-1500 parts of Poria cocos, 950-2500 parts of Chinese yam, 900-1700 parts of walnut kernel, 300-1200 parts of charred CORTEX EUCOMMIAE, wine
Herba Cistanches 3000-6500 parts processed, Herba Epimedii 900-3500 parts processed and semen astragali complanati 900-1700 parts of salt stir-fry.
7. application according to claim 6, which is characterized in that according to parts by weight, 100-900 parts of Radix Glycyrrhizae, raspberry
1000-3000 parts, 600-1700 parts of Semen Cuscutae, 500-1500 parts of fructus lycii, 250-1500 parts of calcined Dragon's bone, wine Fructus Schisandrae (processed) 300-
1200 parts and 500-1800 parts of wine Fructus Corni (processed).
8. application according to claim 1, which is characterized in that according to parts by weight, 1875 parts of dog kidney, 40 parts of deer's sinew, deer
It is 750 parts fine and soft, it takes the lead mouth and goes 7500 parts of pawl sparrow meat, 930 parts of donkey kidney, 500 parts of dried shrimps, 75 parts of hippocampus 3,375 parts of extra large maggot is made
40 parts of leopard bone, 240 parts of gekko, 625 parts of Radix Astragali, 750 parts of ginseng, 1000 parts of Radix Angelicae Sinensis, 375 parts of cortex cinnamomi, 750 parts of radix achyranthis bidentatae, Fructus Caryophylli
2500 parts, 5000 parts of Rehmannia glutinosa, 5000 parts of radix aconiti lateralis preparata, 1250 parts of salt fennel, 1250 parts of salt psoralea corylifolia, 1875 parts of Radix Codonopsis,
It 375 parts of rhizoma cibotii, 750 parts of Poria cocos, 1500 parts of Chinese yam, 1250 parts of walnut kernel, 750 parts of charred CORTEX EUCOMMIAE, 5000 parts of wine Herba Cistanches, makes excessive
2000 parts of the sheep leaves of pulse plants, 1250 parts of semen astragali complanati of salt stir-fry, 375 parts of Radix Glycyrrhizae, 2000 parts of raspberry, 1250 parts of Semen Cuscutae, 750 parts of fructus lycii,
625 parts of calcined Dragon's bone, 750 parts and 750 parts of wine Fructus Corni (processed) of wine Fructus Schisandrae (processed).
9. application according to claim 1, which is characterized in that the Chinese medicine is prepared by the following method to obtain: water
The mixed-powder mixing pill for mentioning condensed cream, wine powder and 29 taste raw materials, is coated with coating agent, obtains the Chinese medicine；
The water mentions condensed cream to boil 2-3 times by Rehmannia glutinosa and before taking the lead the water that mouth goes pawl sparrow meat to add 5-10 times of weight, often
It is secondary to boil 2-5 hours, merge decocting liquid, filtration, filtrate, which is condensed into, mentions condensed cream in the water that 45-55 DEG C of relative density is 1.1-1.5；
The wine powder is to add 3000-5000 times of weight yellow rice wine to set in container donkey kidney, dog kidney, deer's sinew and dried shrimps, is sealed,
It steams until yellow rice wine is exhausted by medicinal material, takes out, dry, pulverize sieving and obtain；
The mixed-powder of the 29 taste raw material includes: pilose antler, hippocampus, extra large maggot, gekko, radix achyranthis bidentatae, ginseng, Radix Astragali, Radix Codonopsis, Poria cocos,
Chinese yam, rhizoma cibotii, Radix Angelicae Sinensis, cortex cinnamomi, walnut kernel, Semen Cuscutae, Fructus Caryophylli, radix aconiti lateralis preparata, leopard bone processed, raspberry, fructus lycii, salt fennel
Perfume (or spice), salt psoralea corylifolia, wine Herba Cistanches, Herba Epimedii processed, salt fry semen astragali complanati, wine Fructus Schisandrae (processed), wine Fructus Corni (processed), calcined Dragon's bone and sweet
The mixed-powder of grass；
The coating agent is to be crushed into powder charred CORTEX EUCOMMIAE, crosses 120 meshes and obtains.
10. according to going application as claimed in claim 9, which is characterized in that the mixed-powder of the 29 taste raw material, wine powder and
Water proposes condensed cream mixing, and proper honey and water, then the step of carrying out pill is added.
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| CN201811539283.1A CN109432266A (en) | 2018-12-14 | 2018-12-14 | Application of the Chinese medicine in preparation anti-hypoxia medicament |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973872A (en) * | 2006-12-04 | 2007-06-06 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Medicine for nourishing Yin, invigorating kidney, strengthening physique and nourishing brain and its prepn |
| CN106138605A (en) * | 2016-04-22 | 2016-11-23 | 李光亮 | A kind of invigorating the kidney and strengthening the bones wine and preparation method thereof |
| CN106421355A (en) * | 2016-04-22 | 2017-02-22 | 李光亮 | Kidney tonifying and bone reinforcing wine and making method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973872A (en) * | 2006-12-04 | 2007-06-06 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Medicine for nourishing Yin, invigorating kidney, strengthening physique and nourishing brain and its prepn |
| CN106138605A (en) * | 2016-04-22 | 2016-11-23 | 李光亮 | A kind of invigorating the kidney and strengthening the bones wine and preparation method thereof |
| CN106421355A (en) * | 2016-04-22 | 2017-02-22 | 李光亮 | Kidney tonifying and bone reinforcing wine and making method thereof |
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Application publication date: 20190308 |