CN110496181B - Chinese medicinal capsule and its preparation method - Google Patents
Chinese medicinal capsule and its preparation method Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a Chinese medicinal capsule preparation and its preparing process, wherein the capsule is prepared from gecko, hispid fig root, Chinese yam, epimeddium and yerbadetajo herb. The traditional Chinese medicine capsule preparation is prepared from natural hormone medicinal materials of animals and plants, is convenient to obtain, has little side effect, and adapts to the life law of human bodies and nature. The invention uses the medicine entering the kidney channel such as gecko, epimedium herb and the like to warm the kidney, benefit the lung and relieve asthma, can relieve the stable period of chronic obstructive pulmonary disease, can improve the walking ability of patients after treatment, can reduce the acute attack times of COPD and can improve the body mass index of the patients.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine capsule preparation and a preparation method thereof.
Background
Chronic Obstructive Pulmonary Disease (COPD) is an important chronic disease of the respiratory system with high prevalence and high mortality. COPD is a longer course and stable treatment is beneficial to improve the quality of life of patients and to improve the psychological state of patients. Clinically, for the treatment of COPD in the stationary phase, most western medicine uses long-acting or short-acting bronchodilators, such as LAMA (long-acting anticholinergic), LABA (long-acting beta receptor agonist), ICS (glucocorticoid) and the like. Doctors often use 2-3 kinds of expanding agents comprehensively, but the defects of long treatment period, high cost and easy generation of drug resistance and side effects after long-term use exist.
The traditional Chinese medicine has the advantages of treating the disease and seeking the basis, and strengthening and protecting healthy qi to drive out evil in the stable period of COPD. COPD belongs to the categories of 'lung distention' and 'asthma syndrome' in traditional Chinese medicine, and the pathogenesis changes are complex. In the clinical stable phase, lung qi or lung yin deficiency, lung-spleen qi deficiency, lung-kidney deficiency and the like are mainly seen, and although the disease is located in the lung, it is closely related to the spleen and kidney. In the past, lung and spleen qi deficiency pathogenesis is taken as a research object, a 'banking up and golden' treatment rule is proposed, clinically commonly used medicaments for tonifying spleen, tonifying lung and replenishing qi such as Yupingfeng powder, six monarch drugs decoction, ginseng, poria and largehead atractylodes rhizome powder and the like are used, and the method for treating the stable stage of the disease by tonifying lung and kidney is rarely involved.
According to the existing problems, the development of a traditional Chinese medicine for tonifying lung and kidney aiming at chronic obstructive pulmonary disease is a problem to be solved urgently at present.
Disclosure of Invention
The invention mainly aims at a preparation method of a traditional Chinese medicine capsule preparation.
The invention also aims to provide the traditional Chinese medicine capsule preparation prepared by the method.
The invention also aims to provide application of the traditional Chinese medicine capsule preparation.
The formula of the traditional Chinese medicine capsule preparation (namely yang-combined capsule) is originally created by Lijunxiong professor in the traditional Chinese and western medicine combined hospital in Guangdong province, Lijunxiong professor aims at treating respiratory system diseases by combining traditional Chinese and western medicine for many years, and the clinical value of geckos in treating chronic cough and asthma in the COPD stable period is found. Therefore, the formula is selected to be prepared into capsules, and the capsules are convenient to take.
Aiming at the defects of high cost, more side reactions and impairment of vital energy of a human body in the stable period of treating COPD by using a duplex or even a triplet long-acting or short-acting bronchodilator for a long time and the problem of insufficient types of patent medicines of a lung and kidney tonifying prescription in traditional Chinese medicine treatment, the invention aims to supplement a safe, effective and low-cost Chinese patent medicine for tonifying lung and kidney and absorbing qi and relieving asthma, and provides a treatment prescription for strengthening and protecting the qi of two organs of lung and kidney, enhancing the vital energy of the human body, reducing the acute attack times of COPD and improving the life quality for patients in the stable period of COPD.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a Chinese medicinal capsule is prepared from Gecko, hispid Fig, rhizoma Dioscoreae, herba Epimedii, and Ecliptae herba.
Further, the traditional Chinese medicine capsule preparation is prepared from the following components in parts by mass: 2-5 pairs of geckos, 50-80 g of hispid fig, 50-80 g of Chinese yam, 15-45 g of epimedium and 15-45 g of eclipta.
Further, the traditional Chinese medicine capsule preparation is prepared from the following components in parts by mass: 2-3 pairs of geckos, 50-60 g of hispid fig, 50-60 g of Chinese yam, 15-25 g of epimedium and 15-25 g of eclipta.
Further, the traditional Chinese medicine capsule preparation is prepared from the following components in parts by mass: 2 pairs of geckos, 50g of hispid fig, 50g of Chinese yam, 15g of epimedium herb and 15g of yerbadetajo herb.
Further, the composition is at least one of capsules, soft extracts, external patches, tablets and granules.
The preparation method of any one of the above traditional Chinese medicine capsule preparations comprises the following steps:
1) weighing geckos, hispid fig, epimedium and yerbadetajo herb which are subjected to head and foot removal according to any one of the formulas, soaking in water, adding 9-10 times of water for heating and decocting, filtering to obtain a liquid medicine 1 and a residue 1, adding 6-7 times of water for decocting the residue 1, filtering to obtain a liquid medicine 2 and a residue 2, adding 6-7 times of water for decocting the residue 2, filtering to obtain a liquid medicine 3 and a residue 3, and combining the liquid medicines 1-3;
2) concentrating the combined liquid medicine into extract; concentrating to obtain extract;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, and drying at 60-80 ℃;
4) pulverizing, sieving, adding pharmaceutically acceptable adjuvants, mixing, and making into Chinese medicinal capsule.
Further, 9-10 times of water is added for heating and boiling for 2-3 hours, 6-7 times of water is added for heating and boiling for 1.5-2 hours, and 6-7 times of water is added for heating and boiling for 1-1.5 hours.
Further, concentrating the extract obtained in the step 2) to obtain an extract with the volume of 150-200 mL and the relative density of 1.25-1.37.
Further, in the step 4), sieving by using a sieve of 80-100 meshes.
The traditional Chinese medicine capsule preparation has the function of preparing a medicine for preventing/improving the chronic obstructive pulmonary disease in the stable period.
The application of any one of the traditional Chinese medicine capsule preparations in preparing medicines for preventing and treating acute attack in the stable phase of chronic obstructive pulmonary disease.
The using method comprises the following steps: is administered orally
Gecko is gecko, is an animal of Gekkonidae, has salty taste and mild nature, enters lung and kidney meridians, has the effects of absorbing qi, relieving asthma and tonifying lung and kidney, and is an essential drug for treating chronic cough and dyspnea, and also is a monarch drug of the capsule, as modern pharmacological studies show that the gecko has the effects of resisting inflammation, relieving asthma and enhancing immunity and hormone-like effects.
Herba Epimedii is pungent and sweet in flavor, warm in nature, and enters liver and kidney channels, has effects of replenishing vital essence and invigorating kidney, has good curative effect on chronic cough and asthma with kidney deficiency and no inspiration, and related lung diseases (such as chronic bronchitis and COPD stabilization phase) with frequent exacerbation, and is used as ministerial drug.
The five medicines of the traditional Chinese medicine capsule preparation (yang-combined capsule) are medicines with different prescriptions selected according to the traditional Chinese medicine monarch, minister, assistant and guide theory, wherein gecko is monarch and can promote qi and relieve asthma; herba Epimedii is effective in invigorating kidney and tonifying yang, Ecliptae herba is effective in nourishing yin and invigorating kidney, and can be used together for invigorating yin and yang, invigorating kidney and promoting inspiration to relieve asthma; the radix fici simplicissimae and the Chinese yam have the effects of tonifying qi and spleen, enhancing the effects of receiving qi and relieving asthma of monarch drugs and ministerial drugs and are all adjuvant drugs. The whole formula is combined, the formula is simple, effective and powerful, and the effects of tonifying kidney, promoting inspiration, relieving asthma, strengthening spleen, tonifying qi and strengthening exterior are achieved. Similar hormone-like effects and resistance-enhancing effects can also be achieved. In addition, herba Epimedii also has effects of relieving cough and eliminating phlegm.
The invention has the beneficial effects that:
the traditional Chinese medicine capsule preparation (yang-combined capsule) is prepared from natural animal and plant hormone medicinal materials, is convenient to obtain, low in price, green and environment-friendly, and has few side effects. The invention uses the medicine entering the kidney channel such as gecko, epimedium herb and the like, has the effects of benefiting lung and tonifying kidney, particularly warming kidney and benefiting lung and relieving asthma, can prevent/improve/treat the stable stage of chronic obstructive pulmonary disease, can improve the walking ability of a patient after treatment, can reduce the acute attack times of COPD (chronic obstructive pulmonary disease) of the patient and can improve the body mass index of the patient.
Detailed Description
A Chinese medicinal capsule is prepared from Gecko, hispid Fig, rhizoma Dioscoreae, herba Epimedii, and Ecliptae herba.
Preferably, the traditional Chinese medicine capsule preparation is prepared from the following components in parts by mass: 2-5 pairs of geckos, 50-80 g of hispid fig, 50-80 g of Chinese yam, 15-45 g of epimedium and 15-45 g of eclipta.
Preferably, the traditional Chinese medicine capsule preparation is prepared from the following components in parts by mass: 2-3 pairs of geckos, 50-60 g of hispid fig, 50-60 g of Chinese yam, 15-25 g of epimedium and 15-25 g of eclipta.
Preferably, the traditional Chinese medicine capsule preparation is prepared from the following components in parts by mass: 2 pairs of geckos, 50g of hispid fig, 50g of Chinese yam, 15g of epimedium herb and 15g of yerbadetajo herb.
Preferably, the composition is at least one of capsule, soft extract, external patch, tablet and granule.
The preparation method of any one of the above traditional Chinese medicine capsule preparations comprises the following steps:
1) weighing geckos, hispid fig, epimedium and yerbadetajo herb which are subjected to head and foot removal according to any one of the formulas, soaking in water, adding 9-10 times of water for heating and decocting, filtering to obtain a liquid medicine 1 and a residue 1, adding 6-7 times of water for decocting the residue 1, filtering to obtain a liquid medicine 2 and a residue 2, adding 6-7 times of water for decocting the residue 2, filtering to obtain a liquid medicine 3 and a residue 3, and combining the liquid medicines 1-3;
2) concentrating the combined liquid medicine into extract; concentrating to obtain extract;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, and drying at 60-80 ℃;
4) pulverizing, sieving, adding pharmaceutically acceptable adjuvants, mixing, and making into Chinese medicinal capsule.
Preferably, 9-10 times of water is added for heating and boiling for 2-3 hours, 6-7 times of water is added for heating and boiling for 1.5-2 hours, and 6-7 times of water is added for heating and boiling for 1-1.5 hours.
Preferably, the extract obtained in the step 2) is concentrated to 150-200 mL in volume and has a relative density of 1.25-1.37.
Preferably, the step 4) is carried out by sieving with a sieve of 80-100 meshes.
The use of any one of the above traditional Chinese medicine capsule preparations for preventing/ameliorating chronic obstructive pulmonary disease.
Example 1
A Chinese medicinal capsule is prepared from Gecko 2 pairs, hispid Fig 50g, rhizoma Dioscoreae 50g, herba Epimedii 15g, and Ecliptae herba 15 g.
1) Weighing geckos, hispid fig, Chinese yam, epimedium herb and yerbadetajo herb which are subjected to head and foot removal according to the formula, soaking in water, adding 9-10 times of water, heating and decocting for 2-3 hours, filtering to obtain a liquid medicine 1 and a decoction residue 1, adding 6-7 times of water into the decoction residue 1, decocting for 1.5-2 hours, filtering to obtain a liquid medicine 2 and a decoction residue 2, adding 6-7 times of water into the decoction residue 2, decocting for 1-1.5 hours, filtering to obtain a liquid medicine 3 and a decoction residue 3, and combining the liquid medicines 1-3; stirring is carried out frequently in the decoction process so as to facilitate the dissolution of medicinal components;
2) concentrating the combined liquid medicine into extract; concentrating the extract into an extract with the volume of 150-200 mL and the relative density of 1.25-1.37;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, drying at 60-80 ℃, and preventing the thick paste from being burnt;
4) pulverizing, sieving with 100 mesh sieve, adding pharmaceutically acceptable adjuvants, mixing, and making into capsule; the capsules were filled in 650 mg/capsule.
The packaging needs to be sealed by proper materials to prevent pollution, seal, label and packaging container from being damaged.
Example 2
A Chinese medicinal capsule is prepared from Gecko 3 pairs, hispid Fig 60g, rhizoma Dioscoreae 60g, herba Epimedii 25g, and Ecliptae herba 25 g.
1) Weighing gecko, hispid fig, Chinese yam, epimedium herb and yerbadetajo herb according to the formula, soaking in water, adding 9-10 times of water, heating and decocting for 2-3 hours, filtering to obtain a liquid medicine 1 and a decoction residue 1, adding 6-7 times of water into the decoction residue 1, decocting for 1.5-2 hours, filtering to obtain a liquid medicine 2 and a decoction residue 2, adding 6-7 times of water into the decoction residue 2, decocting for 1-1.5 hours, filtering to obtain a liquid medicine 3 and a decoction residue 3, and combining the liquid medicines 1-3; stirring is carried out frequently in the decoction process so as to facilitate the dissolution of medicinal components;
2) concentrating the combined liquid medicine into extract; concentrating the extract into an extract with the volume of 150-200 mL and the relative density of 1.25-1.37;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, drying at 60-80 ℃, and preventing the thick paste from being burnt;
4) pulverizing, sieving with 100 mesh sieve, adding pharmaceutically acceptable adjuvants, mixing, and making into capsule; the capsules were filled in 650 mg/capsule.
Example 3
A Chinese medicinal capsule is prepared from Gecko 5 pairs, hispid Fig 80g, rhizoma Dioscoreae 80g, herba Epimedii 45g, and Ecliptae herba 45 g.
1) Weighing gecko, hispid fig, Chinese yam, epimedium herb and yerbadetajo herb according to the formula, soaking in water, adding 9-10 times of water, heating and decocting for 2-3 hours, filtering to obtain a liquid medicine 1 and a decoction residue 1, adding 6-7 times of water into the decoction residue 1, decocting for 1.5-2 hours, filtering to obtain a liquid medicine 2 and a decoction residue 2, adding 6-7 times of water into the decoction residue 2, decocting for 1-1.5 hours, filtering to obtain a liquid medicine 3 and a decoction residue 3, and combining the liquid medicines 1-3; stirring is carried out frequently in the decoction process so as to facilitate the dissolution of medicinal components;
2) concentrating the combined liquid medicine into extract; concentrating the extract into an extract with the volume of 150-200 mL and the relative density of 1.25-1.37;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, drying at 60-80 ℃, and preventing the thick paste from being burnt;
4) pulverizing, sieving with 100 mesh sieve, adding pharmaceutically acceptable adjuvants, mixing, and making into capsule; the capsules were filled in 650 mg/capsule.
Example 4
A Chinese medicinal capsule is prepared from Gecko 4 pairs, hispid Fig 60g, rhizoma Dioscoreae 60g, herba Epimedii 35g, and Ecliptae herba 30 g.
1) Weighing gecko, hispid fig, Chinese yam, epimedium herb and yerbadetajo herb according to the formula, soaking in water, adding 9-10 times of water, heating and decocting for 2-3 hours, filtering to obtain a liquid medicine 1 and a decoction residue 1, adding 6-7 times of water into the decoction residue 1, decocting for 1.5-2 hours, filtering to obtain a liquid medicine 2 and a decoction residue 2, adding 6-7 times of water into the decoction residue 2, decocting for 1-1.5 hours, filtering to obtain a liquid medicine 3 and a decoction residue 3, and combining the liquid medicines 1-3; stirring is carried out frequently in the decoction process so as to facilitate the dissolution of medicinal components;
2) concentrating the combined liquid medicine into extract; concentrating the extract into an extract with the volume of 150-200 mL and the relative density of 1.25-1.37;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, drying at 60-80 ℃, and preventing the thick paste from being burnt;
4) pulverizing, sieving with 100 mesh sieve, adding pharmaceutically acceptable adjuvants, mixing, and making into capsule; the capsules were filled in 650 mg/capsule.
Example 5
A Chinese medicinal capsule is prepared from Gecko 4 pairs, hispid Fig 70g, rhizoma Dioscoreae 70g, herba Epimedii 30g, and Ecliptae herba 30 g.
1) Weighing gecko, hispid fig, Chinese yam, epimedium herb and yerbadetajo herb according to the formula, soaking in water, adding 9-10 times of water, heating and decocting for 2-3 hours, filtering to obtain a liquid medicine 1 and a decoction residue 1, adding 6-7 times of water into the decoction residue 1, decocting for 1.5-2 hours, filtering to obtain a liquid medicine 2 and a decoction residue 2, adding 6-7 times of water into the decoction residue 2, decocting for 1-1.5 hours, filtering to obtain a liquid medicine 3 and a decoction residue 3, and combining the liquid medicines 1-3; stirring is carried out frequently in the decoction process so as to facilitate the dissolution of medicinal components;
2) concentrating the combined liquid medicine into extract; concentrating the extract into an extract with the volume of 150-200 mL and the relative density of 1.25-1.37;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, drying at 60-80 ℃, and preventing the thick paste from being burnt;
4) pulverizing, sieving with 100 mesh sieve, adding pharmaceutically acceptable adjuvants, mixing, and making into capsule; the capsules were filled in 650 mg/capsule.
The Chinese medicinal capsule preparation prepared by the invention is further tested for curative effect:
1) clinical data are selected from 60 patients meeting COPD diagnosis standards in a national medical hall outpatient service of a combined Chinese and western medicine hospital in Guangdong province from 2018 to 2019 for visiting in 1 month, and the patients are randomly divided into 30 patients in an observation group and a control group. The difference between the observed group and the control group has no statistical significance (P is less than 0.05) compared with the general data such as sex, age, body mass index, COPD grading, course of disease and the like of patients.
2) Method of treatment
The same treatment pattern was used for the acute phase of group 2 according to conventional therapy.
The group 2 stationary phase treatments were as follows:
the control group was not treated with other drugs except for the conventional health promotion.
The observation group orally took the Chinese medicinal capsule preparation (yang-combined capsule, namely, the example 1 of the present invention) prepared by the present invention for treatment. 2 times per day and 2 grains per time.
3) Observation index
a. Compare 2 groups of results from a 6 minute walk experiment before and after treatment: recording walking distance within 6 minutes for 2 groups of patients;
b. comparing the number of COPD episodes in group 2 treatments over 1 year;
c. the change in body mass index before and after treatment was compared in 2 patients.
Therapeutic results
a.2 group comparison of test results 6 minutes before and after treatment
TABLE 12 comparison of results from 6 min before and after treatment group: (
) Unit is rice
Note: compared with the same group before treatment, a is that P is less than 0.05; p is less than 0.05 compared with the control group after treatment.
As a result: as can be seen from Table 1, there was no difference in walking distance between the observation group and the control group at 6 minutes before treatment (P > 0.05); after no treatment with the traditional Chinese medicine, the walking distance of the observed group at 6 minutes is obviously increased compared with that of the group before treatment and the control group (P is less than 0.05).
b.2 group treatment comparison of number of acute episodes of COPD within 1 year
TABLE 22 comparison of the number of acute episodes of COPD within 1 year of treatment group: (
) The unit is the order
Note: compared with the control group, the a: P is less than 0.05.
As a result: as can be seen from table 2, the number of acute attacks in the observation group was significantly reduced compared to the control group 1 year before the treatment in the 2 groups, namely the observation group and the control group. (P < 0.05)
C.2 group pre-and post-treatment body mass index comparison
TABLE 32 pretreatment and hindbody Mass index comparison (
) Unit: kg/m2
Note: compared with the same group before treatment, a is that P is less than 0.05; p is less than 0.05 compared with the control group after treatment.
As a result: as can be seen from Table 3, there was no difference in the body mass index of the observation group and the control group in the 2 groups (P > 0.05); after treatment, the observed body mass index was increased (P < 0.05) compared to both the pre-treatment and control groups, and the body mass index was decreased (P < 0.05) compared to the pre-treatment group. Body mass index refers to BMI, i.e. Body Mass Index (BMI) = weight (kg) ÷ height (m), commonly used to assess the nutritional status of COPD patients. The smaller the BMI, the leaner and weaker the patient, the poorer the nutritional status, and the more acute exacerbation (since COPD is a chronic wasting disease, the nutritional status of patients in the stationary phase is closely related to the number of acute exacerbations of COPD).
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (9)
1. A traditional Chinese medicine capsule preparation for treating a chronic obstructive pulmonary disease in a stable period is characterized by being prepared from the following components in parts by mass: 2-5 pairs of geckos, 50-80 g of hispid fig, 50-80 g of Chinese yam, 15-45 g of epimedium and 15-45 g of eclipta.
2. The traditional Chinese medicine capsule preparation of claim 1, which is prepared from the following components in parts by mass: 2-3 pairs of geckos, 50-60 g of hispid fig, 50-60 g of Chinese yam, 15-25 g of epimedium and 15-25 g of eclipta.
3. The traditional Chinese medicine capsule preparation of claim 1, which is prepared from the following components in parts by mass: 2 pairs of geckos, 50g of hispid fig, 50g of Chinese yam, 15g of epimedium herb and 15g of yerbadetajo herb.
4. The method for preparing a Chinese medicinal capsule preparation of any one of claims 1 to 3, comprising the steps of:
1) weighing gecko, hispid fig, epimedium herb and yerbadetajo herb which are subjected to head and foot removal according to the components in any one of claims 1 to 3, adding 9 to 10 times of water for heating and decocting after soaking in water, filtering and dividing into a liquid medicine 1 and a decoction residue 1, adding 6 to 7 times of water for decocting the decoction residue 1 again, filtering and dividing into a liquid medicine 2 and a decoction residue 2, adding 6 to 7 times of water for decocting the decoction residue 2, filtering and dividing into a liquid medicine 3 and a decoction residue 3, and combining the liquid medicines 1 to 3;
2) concentrating the combined liquid medicine into extract;
3) concentrating, adding the powdered Chinese yam, uniformly stirring, and drying at 60-80 ℃;
4) pulverizing, sieving, adding pharmaceutically acceptable adjuvants, mixing, and making into Chinese medicinal capsule.
5. The preparation method according to claim 4, wherein the mixture is soaked in water, then boiled with 9-10 times of water for 2-3 hours; adding 6-7 times of water into the residue 1, heating and boiling for 1.5-2 hours; and adding 6-7 times of water into the medicine residue 2, and heating and decocting for 1-1.5 hours.
6. The preparation method according to claim 4, wherein the step 2) is performed to obtain an extract with a volume of 150-200 mL and a relative density of 1.25-1.37.
7. The preparation method of claim 4, wherein the step 4) is carried out by sieving with a sieve of 80-100 meshes.
8. A use of the Chinese medicinal capsule preparation of any one of claims 1-3 in preparing a medicament for treating chronic obstructive pulmonary disease in a stable period.
9. Use of the Chinese medicinal capsule preparation of any one of claims 1 to 3 in the preparation of a medicament for treating acute attack in the stationary phase of chronic obstructive pulmonary disease.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234166A (en) * | 2008-02-27 | 2008-08-06 | 河源市金源绿色生命有限公司 | Pharmaceutical combination for treating chronic obstructive pulmonary disease and preparation and application thereof |
| CN102416129A (en) * | 2011-12-02 | 2012-04-18 | 香河县气管炎哮喘医院 | Chinese medicine for treating paracmastic chronic obstructive pulmonary disease |
| CN109602862A (en) * | 2018-11-19 | 2019-04-12 | 刘敏如 | Traditional Chinese medicine for reinforcing spleen to promote digestion composition and its preparation method and application |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101234166A (en) * | 2008-02-27 | 2008-08-06 | 河源市金源绿色生命有限公司 | Pharmaceutical combination for treating chronic obstructive pulmonary disease and preparation and application thereof |
| CN102416129A (en) * | 2011-12-02 | 2012-04-18 | 香河县气管炎哮喘医院 | Chinese medicine for treating paracmastic chronic obstructive pulmonary disease |
| CN109602862A (en) * | 2018-11-19 | 2019-04-12 | 刘敏如 | Traditional Chinese medicine for reinforcing spleen to promote digestion composition and its preparation method and application |
Non-Patent Citations (5)
| Title |
|---|
| 从虚、痰、气、瘀论治慢性阻塞性肺病经验;滑宬等;《环球中医药》;20170706;第10卷(第07期);第853-855页第1.3、1.4节 * |
| 刘敬霞.李建生教授辨脉调气论治慢性阻塞性肺疾病.《中医研究》.2009,第22卷(第12期),第41-44页第3节. * |
| 李俊雄教授治疗支气管哮喘特色经验介绍;曾韵怡等;《中国中医急症》;20170315;第26卷(第03期);第434-436页 * |
| 李建生教授辨脉调气论治慢性阻塞性肺疾病;刘敬霞;《中医研究》;20091210;第22卷(第12期);第41-44页第3节 * |
| 滑宬等.从虚、痰、气、瘀论治慢性阻塞性肺病经验.《环球中医药》.2017,第10卷(第07期),第853-855页第1.3、1.4节. * |
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