CN109419818B - 一种用于治疗肿瘤的埃可病毒 - Google Patents

一种用于治疗肿瘤的埃可病毒 Download PDF

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CN109419818B
CN109419818B CN201710734483.1A CN201710734483A CN109419818B CN 109419818 B CN109419818 B CN 109419818B CN 201710734483 A CN201710734483 A CN 201710734483A CN 109419818 B CN109419818 B CN 109419818B
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echo25
sequence
modified
nucleic acid
cancer
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Chinese (zh)
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CN109419818A (zh
Inventor
程通
王玮
万俊凯
徐龙发
叶祥忠
张军
夏宁邵
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Yang Sheng Tang Co Ltd
Xiamen University
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Yang Sheng Tang Co Ltd
Xiamen University
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Priority to CN201710734483.1A priority Critical patent/CN109419818B/zh
Application filed by Yang Sheng Tang Co Ltd, Xiamen University filed Critical Yang Sheng Tang Co Ltd
Priority to JP2020531804A priority patent/JP7373168B2/ja
Priority to KR1020207008441A priority patent/KR102818964B1/ko
Priority to EP18849336.5A priority patent/EP3674398A4/en
Priority to AU2018320550A priority patent/AU2018320550B2/en
Priority to US16/641,117 priority patent/US11707496B2/en
Priority to CA3073770A priority patent/CA3073770A1/en
Priority to PCT/CN2018/100708 priority patent/WO2019037642A1/zh
Publication of CN109419818A publication Critical patent/CN109419818A/zh
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CN201710734483.1A 2017-08-24 2017-08-24 一种用于治疗肿瘤的埃可病毒 Active CN109419818B (zh)

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Application Number Priority Date Filing Date Title
CN201710734483.1A CN109419818B (zh) 2017-08-24 2017-08-24 一种用于治疗肿瘤的埃可病毒
KR1020207008441A KR102818964B1 (ko) 2017-08-24 2018-08-15 종양 치료용 에코바이러스
EP18849336.5A EP3674398A4 (en) 2017-08-24 2018-08-15 ECHOVIRUS FOR TUMOR TREATMENT
AU2018320550A AU2018320550B2 (en) 2017-08-24 2018-08-15 Echovirus for treating tumor
JP2020531804A JP7373168B2 (ja) 2017-08-24 2018-08-15 腫瘍を治療するためのエコーウイルス
US16/641,117 US11707496B2 (en) 2017-08-24 2018-08-15 Echovirus for treatment of tumors
CA3073770A CA3073770A1 (en) 2017-08-24 2018-08-15 An echovirus for treatment of tumors
PCT/CN2018/100708 WO2019037642A1 (zh) 2017-08-24 2018-08-15 一种用于治疗肿瘤的埃可病毒

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CN201710734483.1A CN109419818B (zh) 2017-08-24 2017-08-24 一种用于治疗肿瘤的埃可病毒

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CN109419818A CN109419818A (zh) 2019-03-05
CN109419818B true CN109419818B (zh) 2021-08-10

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Publication number Priority date Publication date Assignee Title
EP3765048B1 (en) * 2018-03-12 2025-08-27 Mayo Foundation for Medical Education and Research Using infectious nucleic acid to treat cancer
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1784242A (zh) * 2002-12-18 2006-06-07 维若塔歌私人有限公司 通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法
CN101132798A (zh) * 2005-01-17 2008-02-27 溶瘤病毒有限公司 治疗肿瘤的方法和组合物
CN105518128A (zh) * 2013-07-16 2016-04-20 迪特桑有限公司 遗传稳定的溶瘤性rna病毒、其制备方法及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2125032A4 (en) 2007-02-20 2011-02-23 Mayo Foundation CANCER TREATMENT WITH VIRAL NUCLEIC ACID
RU2436873C2 (ru) 2010-01-20 2011-12-20 Федеральное государственное образовательное учреждение высшего профессионального образования "РОССИЙСКИЙ ГОСУДАРСТВЕННЫЙ АГРАРНЫЙ ЗАОЧНЫЙ УНИВЕРСИТЕТ" Устройство для нанесения покрытий
KR101942237B1 (ko) 2011-01-04 2019-01-25 신라젠(주) 종양 항원에 대한 항체의 생산 및 종양용해 우두 바이러스의 투여에 의한 종양 특이적 보체 의존적 세포독성의 생산
RU2496873C1 (ru) * 2012-06-04 2013-10-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (НГУ) ШТАММ ЭНТЕРОВИРУСА КОКСАКИ В6, СЕЛЕКТИВНО ИНФИЦИРУЮЩИЙ И ЛИЗИРУЮЩИЙ ОПУХОЛЕВЫЕ КЛЕТКИ ЧЕЛОВЕКА in vitro
JP6396891B2 (ja) 2013-04-17 2018-09-26 新日本製薬株式会社 遺伝子改変コクサッキーウイルス
CN107669707A (zh) 2017-11-16 2018-02-09 邹罡 埃可病毒作为溶瘤病毒在抗肿瘤中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1784242A (zh) * 2002-12-18 2006-06-07 维若塔歌私人有限公司 通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法
CN101132798A (zh) * 2005-01-17 2008-02-27 溶瘤病毒有限公司 治疗肿瘤的方法和组合物
CN105518128A (zh) * 2013-07-16 2016-04-20 迪特桑有限公司 遗传稳定的溶瘤性rna病毒、其制备方法及用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KP099941.1;Genbank;《Genbank》;20150610;全文 *
Oncolysis of human ovarian cancers by Echovirus Type 1;Darren R. Shafren et al.;《Int. J. Cancer》;20051231;第115卷;全文 *

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