CN109415378A - 水溶性Epothilone衍生物及其制备方法 - Google Patents
水溶性Epothilone衍生物及其制备方法 Download PDFInfo
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- CN109415378A CN109415378A CN201780027084.XA CN201780027084A CN109415378A CN 109415378 A CN109415378 A CN 109415378A CN 201780027084 A CN201780027084 A CN 201780027084A CN 109415378 A CN109415378 A CN 109415378A
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
提供水溶性的通式(I)所示的Epothilone衍生物、制备方法及其中间体，以及它们在制备抑制肿瘤细胞生长的药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610307285 | 2016-05-10 | ||
| CN2016103072852 | 2016-05-10 | ||
| PCT/CN2017/080254 WO2017193757A1 (zh) | 2016-05-10 | 2017-04-12 | 水溶性Epothilone衍生物及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109415378A true CN109415378A (zh) | 2019-03-01 |
| CN109415378B CN109415378B (zh) | 2021-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780027084.XA Active CN109415378B (zh) | 2016-05-10 | 2017-04-12 | 水溶性Epothilone衍生物及其制备方法 |
Country Status (1)
| Country | Link |
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| CN (1) | CN109415378B (zh) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217662A (zh) * | 1996-03-12 | 1999-05-26 | Pg－Txl有限公司 | 水溶性紫杉醇产品 |
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2017
- 2017-04-12 CN CN201780027084.XA patent/CN109415378B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217662A (zh) * | 1996-03-12 | 1999-05-26 | Pg－Txl有限公司 | 水溶性紫杉醇产品 |
Non-Patent Citations (5)
| Title |
|---|
| WANG， HAI-BO等: "Synthesis and Evaluation of A Water-Soluble Epothilone B Prodrug with Remarkably Decreased Toxicity", 《LETTERS IN ORGANIC CHEMISTRY》 * |
| 张海艳等: "聚乙二醇修饰埃坡霉素B偶联物的合成及其体外抗肿瘤作用", 《国际药学研究杂志》 * |
| 汪海波等: "PEG-Epothilone B的合成及其初步抗肿瘤活性研究", 《中国医药工业杂志》 * |
| 王堃: "埃博霉素B的制备分析及PEG修饰", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 黄宪等编著: "《新编有机合成化学》", 31 January 2003 * |
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| Publication number | Publication date |
|---|---|
| CN109415378B (zh) | 2021-11-09 |
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