CN109415372B - 螺-内酰胺nmda受体调节剂及其用途 - Google Patents

螺-内酰胺nmda受体调节剂及其用途 Download PDF

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CN109415372B
CN109415372B CN201780040033.0A CN201780040033A CN109415372B CN 109415372 B CN109415372 B CN 109415372B CN 201780040033 A CN201780040033 A CN 201780040033A CN 109415372 B CN109415372 B CN 109415372B
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CN109415372A (zh
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M·A·克翰
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Aptinyx Inc
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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CN201780040033.0A 2016-05-19 2017-05-18 螺-内酰胺nmda受体调节剂及其用途 Expired - Fee Related CN109415372B (zh)

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US201662338767P 2016-05-19 2016-05-19
US62/338,767 2016-05-19
PCT/US2017/033323 WO2017201283A1 (en) 2016-05-19 2017-05-18 Spiro-lactam nmda receptor modulators and uses thereof

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CN109415372B true CN109415372B (zh) 2021-01-15

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EP (1) EP3458458B1 (enExample)
JP (1) JP6823083B2 (enExample)
KR (1) KR102128675B1 (enExample)
CN (1) CN109415372B (enExample)
AU (1) AU2017267708B2 (enExample)
BR (1) BR112018073663A2 (enExample)
CA (1) CA3024606C (enExample)
CL (1) CL2018003265A1 (enExample)
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WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
MX378566B (es) * 2016-05-19 2025-03-11 Aptinyx Inc Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos.
EA201990424A1 (ru) 2016-08-01 2019-08-30 Аптиникс Инк. Спиролактамовые модуляторы nmda-рецептора и их применение
EP3490974B1 (en) 2016-08-01 2023-12-06 Tenacia Biotechnology (Hong Kong) Co., Limited Spiro-lactam nmda receptor modulators and uses thereof
AU2017305240B2 (en) 2016-08-01 2021-12-09 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
SG11201900546UA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
KR102538803B1 (ko) 2016-08-01 2023-06-01 앱티닉스 인크. 스피로-락탐 nmda 조정제 및 그의 사용 방법
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
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SG11202007251XA (en) * 2018-01-31 2020-08-28 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
US11578072B2 (en) 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
EP3986399A4 (en) * 2019-06-24 2023-06-07 Naurex Inc. Solid forms of tert-butyl (s)-2-((2s,3r) -1-amino-3-hydroxy-1-oxobu tan-2-yl)-1-oxo-2, 5-diazaspiro [3.4] octan e-5-carboxylate and methods of preparing them
TWI887245B (zh) * 2019-06-24 2025-06-21 美商諾雷克斯股份有限公司 用於產生二氮雜螺內醯胺化合物之方法及中間物
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