CN109394912A - A kind of complex external medicine and preparation method thereof for treating inflammatory acne - Google Patents
A kind of complex external medicine and preparation method thereof for treating inflammatory acne Download PDFInfo
- Publication number
- CN109394912A CN109394912A CN201811305702.5A CN201811305702A CN109394912A CN 109394912 A CN109394912 A CN 109394912A CN 201811305702 A CN201811305702 A CN 201811305702A CN 109394912 A CN109394912 A CN 109394912A
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- China
- Prior art keywords
- acid
- tinidazole
- coptis
- dandelion
- butanediol
- Prior art date
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- 239000003814 drug Substances 0.000 title claims abstract description 40
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 29
- 206010000496 acne Diseases 0.000 title claims abstract description 29
- 230000002757 inflammatory effect Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 54
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 36
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229960005053 tinidazole Drugs 0.000 claims abstract description 20
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims abstract description 18
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 18
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 18
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 18
- 241000219099 Parthenocissus quinquefolia Species 0.000 claims abstract description 18
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 claims abstract description 18
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 18
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 18
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960002510 mandelic acid Drugs 0.000 claims abstract description 18
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 18
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 18
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 18
- 241000245665 Taraxacum Species 0.000 claims abstract description 17
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
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- 206010040880 Skin irritation Diseases 0.000 description 6
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- 241000186427 Cutibacterium acnes Species 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229940055019 propionibacterium acne Drugs 0.000 description 5
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- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
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- 241000238876 Acari Species 0.000 description 1
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- 208000007536 Thrombosis Diseases 0.000 description 1
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- 238000011047 acute toxicity test Methods 0.000 description 1
- 229960002916 adapalene Drugs 0.000 description 1
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 description 1
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- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002804 anti-anaphylactic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- 238000010612 desalination reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
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- 230000010534 mechanism of action Effects 0.000 description 1
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/634—Forsythia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of complex external medicines and preparation method thereof for treating inflammatory acne, are made of the raw material of following weight: 250~400g of radix ampelopsis, 250~400g of dandelion, 200~300g of Fructus Forsythiae, 200~300g of radix scutellariae, 200~300g of the coptis, 200~300g of cortex moutan, 20~30g of Clindamycin Hydrochloride, 20~30g of Tinidazole, 10~20g of salicylic acid, 20~30g of mandelic acid, 10~20g of citric acid, 100~200g of Sodium Hyaluronate, 30~40g of butanediol, 10~30g of azone.The present invention reaches clearing heat and detoxicating, antibacterium, anti-inflammatory response, the multi-efficiency for adjusting follicular orifice exception cutin, inhibiting fat secretion, maintaining skin water and oil balance by drug synergism.
Description
Technical field
The invention belongs to treat the technical field of pharmaceuticals of acne more particularly to a kind of compound external-use medicine for treating inflammatory acne
Object and preparation method thereof.
Background technique
Inflammatory acne is to lead to sebum adenemphraxis, micro- life such as secondary propionibacterium acnes due to skin follicle mouth hyperkeratinization
Object infects a kind of inflammatory dermatosis caused.Chinese medicine think the acne interpretation of the cause, onset and process of an illness be lung heat, blood-head or it is damp and hot on attack stasis in head
Portion and chest and back and obtain.Acne is mainly shown as Head And Face and the red inflamed papules of chest and back, warts, tubercle, scar, seriously
Influence the appearance and physical and mental health of patient.The external drug of current treatment acne has antibiotics, and (such as clindamycin and metronidazole is put on the skin
Agent etc.), tretinoin medicines (adapalene gel etc.) and Chinese medicine etc., but curative effect is undesirable mostly, mechanism of action is single or secondary work
With larger, the microorganisms such as propionibacterium acnes, confrontation inflammatory mediator reaction can be killed by lacking one kind, while be adjustable hair follicle again
The abnormal cutin of sebaceous glands opening, the complex external medicine for inhibiting fat secretion, the combination of Chinese tradiational and Western medicine for maintaining skin water and oil balance.
Summary of the invention
In order to solve the problems, such as that existing inflammatory acne therapeutic agent effect is undesirable, the present invention proposes a kind of to treat inflammatory Cuo
Complex external medicine of sore and preparation method thereof, external drug of the invention use plurality of Chinese component and a variety of western medicine components
It is made after proportion, the microorganisms such as propionibacterium acnes can be killed, confrontation inflammatory mediator reacts, adjusting pilosebaceous duct is opened
The abnormal cutin of mouth inhibits fat secretion, maintains skin water and oil balance, and having no stimulation of the skin.
A kind of complex external medicine for treating inflammatory acne, is made of the raw material of following weight:
250~400g of radix ampelopsis, 250~400g of dandelion, 200~300g of Fructus Forsythiae, 200~300g of radix scutellariae, 200~300g of the coptis,
200~300g of cortex moutan, 20~30g of Clindamycin Hydrochloride, 20~30g of Tinidazole, 10~20g of salicylic acid, mandelic acid 20~
30g, 10~20g of citric acid, 100~200g of Sodium Hyaluronate, 30~40g of butanediol, 10~30g of azone.
Further, the complex external medicine of the treatment inflammatory acne, is made of: radix ampelopsis the raw material of following weight
250g, dandelion 250g, Fructus Forsythiae 200g, radix scutellariae 200g, coptis 200g, cortex moutan 200g, Clindamycin Hydrochloride 20g, Tinidazole
20g, salicylic acid 10g, mandelic acid 20g, citric acid 20g, Sodium Hyaluronate 100g, butanediol 30g, azone 10g.
Further, the complex external medicine of the treatment inflammatory acne, is made of: radix ampelopsis the raw material of following weight
300g, dandelion 300g, Fructus Forsythiae 250g, radix scutellariae 250g, coptis 250g, cortex moutan 250g, Clindamycin Hydrochloride 25g, Tinidazole
25g, salicylic acid 15g, mandelic acid 25g, citric acid 25g, Sodium Hyaluronate 150g, butanediol 35g, azone 15g.
Further, the complex external medicine of the treatment inflammatory acne, is made of: radix ampelopsis the raw material of following weight
400g, dandelion 400g, Fructus Forsythiae 300g, radix scutellariae 300g, coptis 300g, cortex moutan 300g, Clindamycin Hydrochloride 30g, Tinidazole
30g, salicylic acid 20g, mandelic acid 30g, citric acid 30g, Sodium Hyaluronate 200g, butanediol 40g, azone 20g.
A method of preparing the complex external medicine of above-mentioned treatment inflammatory acne, comprising the following steps:
A, radix ampelopsis, dandelion, Fructus Forsythiae, radix scutellariae, the coptis and cortex moutan are weighed, powdery is ground into after mixing, and it is added to 200~
Be mixed evenly among the purified water of 300 ml, after being reacted for 24 hours under conditions of 35 DEG C, be added 75% ethyl alcohol 500~
800ml is stirred evenly, and is impregnated 14 days, every 3 days stirring 15min, is then separated, is filtered, take filtrate spare；
B, Tinidazole is weighed, stirring and dissolving among 100 degrees Celsius of 200~300 ml purified waters, then plus hydrochloric acid crin are added to
Mycin, salicylic acid, mandelic acid, citric acid, Sodium Hyaluronate, butanediol stirring and dissolving are added 95% 500~800ml of ethyl alcohol, stir
Filtering, takes filtrate spare after mixing uniformly；
C, it weighs in step a filtrate obtained in filtrate obtained and step b to mix by 1:1, is heated to 45~50 DEG C, adds laurel
Azone stirring and dissolving, be uniformly mixed to get.
Compared with prior art, the present invention have it is apparent the utility model has the advantages that
In the present invention, radix ampelopsis has effects that clearing heat and detoxicating, eliminating stagnation to stop pain, myogenic sore；Dandelion has clearing heat and detoxicating, scattered
The effect of knot detumescence；Fructus Forsythiae has effects that clearing heat and detoxicating, mass dissipating and swelling eliminating, anti-inflammatory response；Radix scutellariae have it is clearing heat and detoxicating, let out clearly
The effect of part of the body cavity above the diaphragm housing the heart and lungs lung-fire；The coptis have effects that purging intense heat eliminating dampness, it is main let out in feel terribly worried fire and stomach fire；Cortex moutan have clearing heat and cooling blood,
It activates blood circulation and disperses blood clots, antianaphylactic effect；Clindamycin Hydrochloride has the function of killing gram-positive bacteria and anaerobic bacteria；Tinidazole tool
Play the role of killing propionibacterium acnes and cutaneous mites；Salicylic acid has removal aging accumulation cutin, inhibits fat secretion, receives
Contracting pore, the effect for inhibiting hair follicle deep inflammation；Mandelic acid has the function of adjusting fat secretion, antibacterial anti-inflammatory, desalination pockmark；
Citric acid, which has, to be softened blocked up accumulation cutin, dissolution acne, eliminates pigmented effect；Sodium Hyaluronate has powerful skin
Skin moisture-keeping function；Butanediol has small molecule deep moisturizing and bacteriostasis；Azone, which has, promotes Drug Percutaneous Absorption
Effect.
Reach clearing heat and detoxicating by drug synergism, antibacterium, anti-inflammatory response, adjust follicular orifice exception cutin, suppression
Fat secretion processed, the multi-efficiency for maintaining skin water and oil balance, compound medicine of the invention can kill propionibacterium acnes and
The microorganisms such as staphylococcus aureus, adjust the abnormal cutin of pilosebaceous follicle opening, inhibit grease point the reaction of confrontation inflammatory mediator
Secrete, maintain skin water and oil balance, to show as erythema, papule, warts, tubercle inflammatory acne tool have a better effect, and
No obvious stimulation effect, is verified through clinical test, significant in efficacy.
Specific embodiment
Beneficial effects of the present invention are further elaborated below by following test.
Test 1: acute toxicity test in mice
According to trial test as a result, using HornShi method, if 21500/kg, 10000/kg, 4640/kg, 2150/kg 4
Dosage group, experimental animal select Kun Ming mice, and 18~22 grams of weight, 10 animals of each dosage group are female, male fifty-fifty, adopt
Intragastrically is calculated to tested material, stomach-filling volume by 0.4mL/10g weight, is observed two weeks.
Test result: the nontoxic grade in the true border of acute toxicity.
Test 2: multiple Skin Irritation Test
Using multiple Skin Irritation Test method, experimental animal selects adult white rabbit 4 of health, weight be 2Kg it is left,
The right side, test cut family's rabbit back backbone diamond wool in first 24 hours, and unhairing range left and right side is 3 × 3 square centimeters, respectively
Test side and control sides are set as, takes external drug 0.5mL of the invention to be applied on rabbit test side skin, smears one daily
It is secondary, it is continuous to smear 14 days；Control sides smear distilled water, observe dermoreaction daily, and experiment terminates to take the spreader portion of test side
Position skin carries out histopathologic examination.
Test result: all tested skin is showed no the skin wound repairs such as erythema, oedema and furfur, multiple skin irritatin
Exponential integral is zero；Histopathologic examination, epidermis and corium find no pathological change, and pathologic diagnosis integral is
Zero.
It is evaluated according to the evaluation criterion of multiple Skin Irritation Test, to no skin irritation.
Test 3: Skin Irritation Test
Using a Skin Irritation Test method, experimental animal selects adult white rabbit 4 of health, and weight 2~
2.5Kg；
Test cuts family's rabbit back backbone diamond wool in preceding 24 hours, is set to test side and control sides, take it is of the invention outside
Skin of back with drug 0.5mL drop on four layers of gauze of 2.5 × 2.5cm size, by gauze application in rabbit test side
On, gauze then is covered with one layer of glassine paper, then use immobilization with adhesive tape；Control sides have the gauze of distilled water to compare with drop, apply
6 hours, 4 hours, the 24 hours and 48 hours observation local skins reaction after removing gauze.
Test result, 4 hours, 24 hours and 48 hours test side local skins after removing gauze are without erythema and oedema
It is formed, skin wound repair intensity ratings are 0 point.
It is evaluated according to skin irritatin intensity evaluation standard, is had no stimulation to family's rabbit skin.
Test 4: eye irritant test
With healthy adult rabbit 4, the side eye conjunctiva that external drug of the invention is instilled rabbit is intracapsular, 2 drop of drop, another
Drop distilled water compares in branch hole conjunctival sac.6 hours, 24 hours, 48 hours and 4 days after eye drip, after 7 days, rabbit eyes are checked
Conjunctiva, the damage of iris and cornea and recovery situation.
Test result, the eye of rabbit two sides is showed no the eyes such as conjunctiva, iris hyperemia, oedema and secretion at the appointed time
Stimulate the reaction, has no the opacity of the cornea, and acute eye irritation score index is zero.
According to the evaluation criterion to Eye irritation intensity, external drug of the invention is nonirritant to eye.
Test 5: clinical observation
Patient 80 with facial inflammatory acne are selected, treatment group and control group are randomly divided into.Treatment group uses this drug,
Daily affected part is respectively embrocated in the morning, afternoon and evening 3 times, totally 4 weeks.Control group uses clindamycin and metronidazole liniment, and application method is the same.As a result
Display: treatment group fully recovers 20, and effective 17, effective 3, invalid 0, obvious effective rate 92.50%.Control group is fully recovered 9, is shown
Effect 16, effective 16, invalid 1, obvious effective rate 57.50%.The obvious effective rate difference for the treatment of group and control group is statistically significant
(P < 0.05).
Below by specific embodiment, the technical scheme of the present invention will be explained in further detail.
Embodiment 1
A kind of complex external medicine for treating inflammatory acne, is made of the raw material of following weight:
Radix ampelopsis 250g, dandelion 250g, Fructus Forsythiae 200g, radix scutellariae 200g, coptis 200g, cortex moutan 200g, Clindamycin Hydrochloride
20g, Tinidazole 20g, salicylic acid 10g, mandelic acid 20g, citric acid 20g, Sodium Hyaluronate 100g, butanediol 30g, azone
10g。
A kind of preparation method of complex external medicine that treating inflammatory acne, comprising the following steps:
A, radix ampelopsis 250g, dandelion 250g, Fructus Forsythiae 200g, radix scutellariae 200g, coptis 200g and cortex moutan 200g are weighed, is ground after mixing
Powdery is worn into, is added among the purified water of 200ml and is mixed evenly, after being reacted for 24 hours under conditions of 35 DEG C, is added
75% ethyl alcohol 500ml, stirs evenly, and impregnates 14 days, every 3 days stirring 15min, then separates, filters, take filtrate spare；
B, weigh Tinidazole 20g, be added to 100 degrees Celsius, stirring and dissolving among the purified water of 200ml, then plus hydrochloric acid crin it is mould
Plain 20g, salicylic acid 10g, mandelic acid 20g, citric acid 20g, Sodium Hyaluronate 100g, butanediol 30g stirring and dissolving are added 95%
Ethyl alcohol 500ml, is filtered after mixing evenly, takes filtrate spare；
C, it weighs in step a filtrate obtained in filtrate obtained and step b to mix by 1:1, is heated to 45~50 DEG C, adds laurel
Azone 10g stirring and dissolving, be uniformly mixed to get.
Embodiment 2
A kind of complex external medicine for treating inflammatory acne, is made of the raw material of following weight:
Radix ampelopsis 300g, dandelion 300g, Fructus Forsythiae 250g, radix scutellariae 250g, coptis 250g, cortex moutan 250g, Clindamycin Hydrochloride
25g, Tinidazole 25g, salicylic acid 15g, mandelic acid 25g, citric acid 25g, Sodium Hyaluronate 150g, butanediol 35g, azone
15g。
A kind of preparation method of complex external medicine that treating inflammatory acne, comprising the following steps:
A, radix ampelopsis 300g, dandelion 300g, Fructus Forsythiae 250g, radix scutellariae 250g, coptis 250g and cortex moutan 250g are weighed, is ground after mixing
Powdery is worn into, is added among the purified water of 300ml and is mixed evenly, after being reacted for 24 hours under conditions of 35 DEG C, is added
75% ethyl alcohol 700ml, stirs evenly, and impregnates 14 days, every 3 days stirring 15min, then separates, filters, take filtrate spare；
B, Tinidazole 25g is weighed, is added to 100 degrees Celsius, stirring and dissolving among 300ml purified water, then plus Clindamycin Hydrochloride
25g, Tinidazole 25g, salicylic acid 15g, mandelic acid 25g, citric acid 25g, Sodium Hyaluronate 150g and butanediol 35g stirring are molten
Solution is added 95% ethyl alcohol 700ml, filters after mixing evenly, take filtrate spare；
C, it weighs in step a filtrate obtained in filtrate obtained and step b to mix by 1:1, is heated to 45~50 DEG C, adds laurel
Azone 15g stirring and dissolving, be uniformly mixed to get.
Embodiment 3
A kind of complex external medicine for treating inflammatory acne, is made of the raw material of following weight:
Radix ampelopsis 400g, dandelion 400g, Fructus Forsythiae 300g, radix scutellariae 300g, coptis 300g, cortex moutan 300g, Clindamycin Hydrochloride
30g, Tinidazole 30g, salicylic acid 20g, mandelic acid 30g, citric acid 30g, Sodium Hyaluronate 200g, butanediol 40g, azone
20g。
A kind of preparation method of complex external medicine that treating inflammatory acne, comprising the following steps:
A, radix ampelopsis 400g, dandelion 400g, Fructus Forsythiae 300g, radix scutellariae 300g, coptis 300g and cortex moutan 300g are weighed, is ground after mixing
Powdery is worn into, is added among 300ml purified water and is mixed evenly, after reacting for 24 hours under conditions of 35 DEG C, is added 75%
Ethyl alcohol 700ml, stirs evenly, and impregnates 14 days, every 3 days stirring 15min, then separates, filters, take filtrate spare；
B, Tinidazole 30g is weighed, is added to 100 degrees Celsius, stirring and dissolving among 300ml purified water, then plus Clindamycin Hydrochloride
30g, Tinidazole 30g, salicylic acid 20g, mandelic acid 30g, citric acid 30g, Sodium Hyaluronate 200g and butanediol 40g stirring are molten
Solution is added 95% ethyl alcohol 700ml, filters after mixing evenly, take filtrate spare；
C, it weighs in step a filtrate obtained in filtrate obtained and step b to mix by 1:1, is heated to 45~50 DEG C, adds laurel
Azone 20g stirring and dissolving, be uniformly mixed to get.
Claims (5)
1. a kind of complex external medicine for treating inflammatory acne, which is characterized in that be made of the raw material of following weight:
250~400g of radix ampelopsis, 250~400g of dandelion, 200~300g of Fructus Forsythiae, 200~300g of radix scutellariae, 200~300g of the coptis,
200~300g of cortex moutan, 20~30g of Clindamycin Hydrochloride, 20~30g of Tinidazole, 10~20g of salicylic acid, mandelic acid 20~
30g, 10~20g of citric acid, 100~200g of Sodium Hyaluronate, 30~40g of butanediol, 10~30g of azone.
2. the complex external medicine for the treatment of inflammatory acne according to claim 1, which is characterized in that by the original of following weight
Material composition: radix ampelopsis 250g, dandelion 250g, Fructus Forsythiae 200g, radix scutellariae 200g, coptis 200g, cortex moutan 200g, Clindamycin Hydrochloride
20g, Tinidazole 20g, salicylic acid 10g, mandelic acid 20g, citric acid 20g, Sodium Hyaluronate 100g, butanediol 30g, azone
10g。
3. the complex external medicine for the treatment of inflammatory acne according to claim 1, which is characterized in that by the original of following weight
Material composition: radix ampelopsis 300g, dandelion 300g, Fructus Forsythiae 250g, radix scutellariae 250g, coptis 250g, cortex moutan 250g, Clindamycin Hydrochloride
25g, Tinidazole 25g, salicylic acid 15g, mandelic acid 25g, citric acid 25g, Sodium Hyaluronate 150g, butanediol 35g, azone
15g。
4. the complex external medicine for the treatment of inflammatory acne according to claim 1, which is characterized in that by the original of following weight
Material composition: radix ampelopsis 400g, dandelion 400g, Fructus Forsythiae 300g, radix scutellariae 300g, coptis 300g, cortex moutan 300g, Clindamycin Hydrochloride
30g, Tinidazole 30g, salicylic acid 20g, mandelic acid 30g, citric acid 30g, Sodium Hyaluronate 200g, butanediol 40g, azone
20g。
5. a kind of preparation method of the complex external medicine of the inflammatory acne for the treatment of as described in claim 1, which is characterized in that including
Following steps:
A, radix ampelopsis, dandelion, Fructus Forsythiae, radix scutellariae, the coptis and cortex moutan are weighed, powdery is ground into after mixing, and it is added to 200~
Be mixed evenly among the purified water of 300 ml, after being reacted for 24 hours under conditions of 35 DEG C, be added 75% ethyl alcohol 500~
800ml is stirred evenly, and is impregnated 14 days, every 3 days stirring 15min, is then separated, is filtered, take filtrate spare；
B, Tinidazole is weighed, stirring and dissolving among 100 degrees Celsius of 200~300 ml purified waters, then plus hydrochloric acid crin are added to
Mycin, salicylic acid, mandelic acid, citric acid, Sodium Hyaluronate, butanediol stirring and dissolving are added 95% 500~800ml of ethyl alcohol, stir
Filtering, takes filtrate spare after mixing uniformly；
C, it weighs in step a filtrate obtained in filtrate obtained and step b to mix by 1:1, is heated to 45~50 DEG C, adds laurel
Azone stirring and dissolving, be uniformly mixed to get.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259172A (en) * | 2007-03-06 | 2008-09-10 | 上海家化联合股份有限公司 | Chinese medicinal composition for treating acne, preparation and application thereof |
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2018
- 2018-11-05 CN CN201811305702.5A patent/CN109394912A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259172A (en) * | 2007-03-06 | 2008-09-10 | 上海家化联合股份有限公司 | Chinese medicinal composition for treating acne, preparation and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 孙炬华等: "复方克林霉素凝胶的研制及疗效观察", 《首都医药》 * |
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Application publication date: 20190301 |