CN109381364A - A kind of toothpaste containing sanguinarine - Google Patents
A kind of toothpaste containing sanguinarine Download PDFInfo
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- CN109381364A CN109381364A CN201710673957.6A CN201710673957A CN109381364A CN 109381364 A CN109381364 A CN 109381364A CN 201710673957 A CN201710673957 A CN 201710673957A CN 109381364 A CN109381364 A CN 109381364A
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- CN
- China
- Prior art keywords
- sanguinarine
- toothpaste
- toothpaste containing
- containing sanguinarine
- plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of toothpaste containing sanguinarine, and the amount that wherein sanguinarine effective ingredient is added in toothpaste is 1-100ppm by mass；The sanguinarine is frequently seen plants such as greater celandine, macleaya cordata, in the plants such as snowpoppy obtained by traditional method for extracting；Toothpaste containing sanguinarine can reach preferable anti-inflammatory, and the effect of analgesic can improve oral health, especially have special efficacy to prevention or treatment canker sore, the mouth diseases such as swelling and aching of gum.
Description
Technical field
The invention belongs to daily-use chemical industry technical fields, and in particular to a kind of toothpaste containing sanguinarine.
Background technique
Toothpaste is by rubbing agent, wetting agent, surfactant, adhesive, fragrance, sweetener, water and other function
Additive is constituted.In functional additive, there are many kinds of selections now, can give tooth, and oral tape protects effect well
Fruit, such as vitamin E, tea polyphenols, calcirm-fluoride, Baical Skullcap root P.E, Notogineng Extract etc., specific effect are mainly two classes, a kind of
Mainly mothproof for tooth, whitening is another kind of to be directed to oral cavity gum, mainly anti-inflammatory, analgesic.Different additives are to tooth
Cream brings different functions, there is different attractions.
Sanguinarine is present in various plants, due to its extensive pharmacological action, by the traditional medicine of Chinese medicine and North America
Using having there is several centuries.Sanguinarine is antibacterial anti-inflammatory for treating various diseases, primary efficacy usually as Chinese medicine, is killed
Worm improves liver function, strengthen immunity, and according to domestic and international research, sanguinarine also has the effect of antitumor.
Currently, the Chinese medicine containing sanguinarine has been taken in by Compendium of Materia Medica in Chinese medicine, as macleaya cordata is (main effective
Composition is confirmed as sanguinarine through modern analysis) it has been widely used, it is interior with the scattered stasis of blood, wind-dispelling, removing toxic substances, analgesic, desinsection.Outside
With main pain sore malignant boil swollen, ulcer on the shank, hemorrhoid, eczema, snakebite and bugbite, treating swelling and pain by traumatic injury, rheumatic arthritis, caries pain, tinea etc..
Usual administration mode for oral administration is to take after decocting, and external application is made into emulsifiable paste, the patches such as emplastrum and affected part.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of toothpaste containing sanguinarine, it can achieve preferable pre- anti-caries
With the effect for improving oral health, in the toothpaste containing sanguinarine, the sanguinarine is as functional additive, effective ingredient
The amount added in toothpaste is 1-1000ppm by mass.
Preferred additive amount is 10-100ppm by mass.
The sanguinarine is frequently seen plants such as greater celandine, macleaya cordata, in the plants such as snowpoppy obtained by traditional method for extracting.
Preferably macleaya cordata, red root alkali content are more.Sanguinarine is in the content in extract usually between 20%-90%.It is described
Traditional extraction process extracted from plant tissue to use water, sour water or solvent by the methods of impregnating, boiling
Effect composition passes through neutralization again, and filtering or the method being concentrated are made into the various extracting modes of solid.
Toothpaste of the present invention may also include rubbing agent, wetting agent, surfactant, adhesive, fragrance and water.Friction
Agent can be one kind of calcium carbonate, dicalcium phosphate dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, silicic acid hydrate or aluminium hydroxide etc.
Or it is any a variety of.Wetting agent can be one kind or any a variety of of glycerol, propylene glycol, sorbierite etc..Surfactant is generally adopted
It with neutral detergent, such as sodium lauryl sulfonate, can foam, and the dirt in capable of rinsing the mouth, free from extraneous odour.Adhesive can make tooth
Ingredient is uniformly dispersed in cream, and range of choice generally comprises sanlose and its derivative, sodium alginate.Fragrance is general
For pennyroyal fragrance, specifically peppermint oil, menthol, toothpaste can be assigned and clearly felt, fruits essence, such as citrus are also possible to
Class essence etc. or the other types of fragrance for being adapted to enter into oral cavity.
It has been found that concentration of the sanguinarine in toothpaste is given by way of brushing teeth in the oral cavity in 1-1000ppm
Medicine can give full play to the glucosyl group for inhibiting to produce cariogenic Streptococcus mutans growth in oral cavity and reducing synthesis glucan
The active effect of transferase (GTF), to reach the generation of the water-insoluble glucan (WIG) for inhibiting strong adhesion and acid
Effect prevents plaque from generating, and then achievees the effect that pre- anti-caries.The antibacterial and anti-inflammation functions of sanguinarine can be good at simultaneously
Improve oral health, especially to swelling and aching of gum, canker sore has special efficacy, plays good preventive and therapeutic action.
Peter J Becci et al. (Journal of Toxicology and Environmental Health,
1987,20:199-208) studies have shown that the LD50 of Oral Administration in Rats sanguinarine is 1658mg/kg, the LD50 of intravenous injection is
29mg/kg is added after 150 μ g/g sanguinarine are fed 15 days and the stomach-filling of 0.6mg/g dosage 30 days in rat daily ration and is had no big
There is toxic reaction in mouse, and the LD50 of rabbit intramuscular injection sanguinarine is 1658mg/kg.Therefore, it is added in sanguinarine of the invention
It is safe and reliable to human body in dosage.
Specific embodiment:
The present invention is further described in following embodiment, but not as the limitation of the invention.
Following percentage is mass percent, and macleaya cordata fruit pod as described below is purchased from Hunan Yuanling
The acquisition of 1 sanguinarine of embodiment
Sanguinarine is a kind of natural alkaloid present in many plants, and the present embodiment is fallen with traditional extracting method from rich
It returns in fruit pod and has extracted sanguinarine effective component, and in the toothpaste preparation after being used in.
Macleaya cordata fruit pod 100g is taken, 40 mesh are crushed to, the hydrochloric acid solution 300ml of 1mol/L is added, ultrasonic room temperature extracts 3
Secondary, 15 minutes every time, filtering, combined extract was neutralized to PH=8 with the NaOH of 1mol/L, solid is precipitated, filtered, and concentration obtains
To dark red solid, as sanguinarine extract, through high performance liquid chromatography detection, wherein red root alkali content is 30-50%.
The formula of toothpaste of the embodiment 2 containing sanguinarine
Sanguinarine 0.1g (is calculated, converted by sanguinarine prepared by embodiment 1 according to content) with scale, dicalcium phosphate dihydrate
450g, glycerol 100g, sorbierite 100g, carboxymethyl cellulose 10g, Sodium Laurylsulfate 50g, menthol 100g add water to be made into always
Weight 1000g obtains the functional toothpaste of the 100ppm of effective ingredient containing sanguinarine with commonsense method mixing.
Formulation of tooth-paste of the embodiment 3 containing sanguinarine
Sanguinarine 0.01g (is calculated, converted by sanguinarine prepared by embodiment 1 according to content) with scale, calcium pyrophosphate
450g, glycerol 100g, sorbierite 100g, carboxymethyl cellulose 10g, Sodium Laurylsulfate 50g, menthol 100g add water to be made into always
Weight 1000g obtains the functional toothpaste of the 10ppm of effective ingredient containing sanguinarine with commonsense method mixing.
Formulation of tooth-paste of the embodiment 4 containing sanguinarine
Sanguinarine 0.001g (is calculated, converted by sanguinarine prepared by embodiment 1 according to content) with scale, calcium pyrophosphate
450g, glycerol 100g, sorbierite 100g, carboxymethyl cellulose 10g, Sodium Laurylsulfate 50g, menthol 100g add water to be made into always
Weight 1000g obtains the functional toothpaste of the 1ppm of effective ingredient containing sanguinarine with commonsense method mixing.
Formulation of tooth-paste of the embodiment 5 containing sanguinarine
Sanguinarine 1g (is calculated, converted by sanguinarine prepared by embodiment 1 according to content) with scale, calcium pyrophosphate 450g,
Glycerol 100g, sorbierite 100g, carboxymethyl cellulose 10g, Sodium Laurylsulfate 50g, menthol 100g add water to be made into total weight
1000g obtains the functional toothpaste of the 1000ppm of effective ingredient containing sanguinarine with commonsense method mixing.
Above description is not limitation of the present invention, and the present invention is also not limited to the example above, the art it is common
Technical staff, within the scope of the invention, the variation made change addition or replacement, all should belong to protection scope of the present invention.
Claims (3)
1. a kind of toothpaste containing sanguinarine, it is characterised in that: the amount that the sanguinarine effective ingredient is added in toothpaste is by quality
It is calculated as 1-1000ppm.
2. a kind of toothpaste containing sanguinarine according to claim 1, it is characterised in that: preferred additive amount is by mass
For 10-100ppm.
3. a kind of toothpaste containing sanguinarine according to claim 1, it is characterised in that: further include friction in the toothpaste
Agent, wetting agent, surfactant, adhesive, fragrance and water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710673957.6A CN109381364A (en) | 2017-08-09 | 2017-08-09 | A kind of toothpaste containing sanguinarine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710673957.6A CN109381364A (en) | 2017-08-09 | 2017-08-09 | A kind of toothpaste containing sanguinarine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109381364A true CN109381364A (en) | 2019-02-26 |
Family
ID=65415098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710673957.6A Pending CN109381364A (en) | 2017-08-09 | 2017-08-09 | A kind of toothpaste containing sanguinarine |
Country Status (1)
| Country | Link |
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| CN (1) | CN109381364A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4590061A (en) * | 1983-12-29 | 1986-05-20 | Vipont Laboratories, Inc. | Antimicrobial plaque disclosing agent |
| US4689216A (en) * | 1986-03-20 | 1987-08-25 | Vipont Laboratories, Inc. | Sanguinarine dental compositions with hydrated silica |
| CN101795686A (en) * | 2007-09-06 | 2010-08-04 | 高露洁-棕榄公司 | Dentifrice compositions for treating xerostomia |
| CN107184403A (en) * | 2017-06-22 | 2017-09-22 | 缪来耿 | A kind of toothpaste and preparation method thereof |
-
2017
- 2017-08-09 CN CN201710673957.6A patent/CN109381364A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4590061A (en) * | 1983-12-29 | 1986-05-20 | Vipont Laboratories, Inc. | Antimicrobial plaque disclosing agent |
| US4689216A (en) * | 1986-03-20 | 1987-08-25 | Vipont Laboratories, Inc. | Sanguinarine dental compositions with hydrated silica |
| CN101795686A (en) * | 2007-09-06 | 2010-08-04 | 高露洁-棕榄公司 | Dentifrice compositions for treating xerostomia |
| CN107184403A (en) * | 2017-06-22 | 2017-09-22 | 缪来耿 | A kind of toothpaste and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| J.J HANNAH DDS等: "Long-term clinical evaluation of toothpaste and oral rinse containing sanguinaria extract in controlling plaque, gingival inflammation, and sulcular bleeding during orthodontic treatment", 《AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS》 * |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190226 |
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