CN109350300A - Dog porcine head nose formula Inhalation device - Google Patents
Dog porcine head nose formula Inhalation device Download PDFInfo
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- CN109350300A CN109350300A CN201811390724.6A CN201811390724A CN109350300A CN 109350300 A CN109350300 A CN 109350300A CN 201811390724 A CN201811390724 A CN 201811390724A CN 109350300 A CN109350300 A CN 109350300A
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- 238000011109 contamination Methods 0.000 claims abstract description 85
- 210000003739 neck Anatomy 0.000 claims abstract description 55
- 238000002474 experimental method Methods 0.000 claims abstract description 34
- 239000007788 liquid Substances 0.000 claims abstract description 34
- 238000010171 animal model Methods 0.000 claims abstract description 30
- 239000000443 aerosol Substances 0.000 claims abstract description 29
- 239000002699 waste material Substances 0.000 claims abstract description 26
- 238000009833 condensation Methods 0.000 claims abstract description 25
- 230000005494 condensation Effects 0.000 claims abstract description 25
- 238000000926 separation method Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000005259 measurement Methods 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000003825 pressing Methods 0.000 claims description 32
- 238000010790 dilution Methods 0.000 claims description 27
- 239000012895 dilution Substances 0.000 claims description 27
- 238000000889 atomisation Methods 0.000 claims description 20
- 238000007789 sealing Methods 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 238000007373 indentation Methods 0.000 claims description 10
- 239000007921 spray Substances 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 10
- 239000012535 impurity Substances 0.000 claims description 9
- 238000005260 corrosion Methods 0.000 claims description 8
- 230000007797 corrosion Effects 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 4
- 238000009434 installation Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000012780 transparent material Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000003575 carbonaceous material Substances 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims description 2
- 230000003670 easy-to-clean Effects 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 241000233855 Orchidaceae Species 0.000 claims 1
- 238000013329 compounding Methods 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 230000002906 microbiologic effect Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 32
- 230000029058 respiratory gaseous exchange Effects 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 238000000034 method Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Housing For Livestock And Birds (AREA)
Abstract
The present invention provides a kind of dog porcine head nose formula Inhalation device, contamination cabin connect the contamination condensation aerosol for receiving controlled concentration with atomising device and is stirred evenly by mixing fan, the salable neck for fixing more dog porcine experimental animals of several neck seal windows for cabin of contaminating extend into contamination cabin by its head and nose while receiving Inhalation experiment, concentration sample mouth by neck seal window can acquire the concentration of measurement contamination aerosol, the following separation threeway of cabin of contaminating will contaminate exhaust gas by pneumatic filter and exhaust pump discharge, contamination waste liquid in waste liquid chamber is discharged by manual water valve and dewatering outlet, cabin bracket support contamination cabin simultaneously tested with adapting to operator's completion Inhalation by adjustable height.The beneficial effects of the invention are as follows solving dog porcine experimental animal to be not easy to carry out the technical problem of Inhalation experiment, provides a kind of can facilitate and seal fixed more dog porcine experimental animal necks while carrying out an experimental provision for nose formula Inhalation.
Description
Technical field
The present invention provides a kind of dog porcine head nose formula Inhalation device.
Background technique
Respiration test is carried out using animal especially dog porcine animals in recent years to pollute to study in respiratory medications and air
Object flourishes for the simulation experiment study of anthropogenic influence and application, and the respiration test of dog porcine experimental animal is adopted at present
Most of method is only to bundle dog porcine experimental animal and simply pass through the respiratory surface enclosure on animal nose soft
Pipe is connected to atomising device, without the fixing means of good experimental animal, the tension of bundle will affect experimental animal breathing and
Normal physiological limits, binding not will cause phenomena such as midway is escaped tightly, and breathing mask leakage and blow-by will cause respiration test
Inaccuracy and pollution environment, pipeline is not smooth can also to cause breathing anoxic to influence experiment sometimes, and cannot more experiments it is dynamic
Object does Inhalation experiment simultaneously, and various reasons limit the development of scientific research, so most of laboratories are carrying out dog pig
Being affected and restrict during class experimental animal respiration test becomes when previous big technical problem, develops a kind of facilitate and seals admittedly
Determine the neck of dog porcine experimental animal, the dedicated respiration test equipment of the dog porcine that more experimental animals can be tested simultaneously at
For current urgent needs.
Summary of the invention
To solve the above problems, the object of the present invention is to provide a kind of dog porcine head nose formula Inhalation devices, using more
A neck seal window fixes neck and the sealing of more dog porcine experimental animals to facilitate, and guarantee makes its head and nose complete
It extend into contamination cabin while carrying out Inhalation experiment and do not reveal, atomising device guarantees that the aerosol of sucking is controlled concentration
And uniformly, it is ensured that the reliability and precision of experiment being normally carried out with experimental data.
To achieve the above object, the technical solution adopted by the present invention is that the contamination cabin of the device connect with atomising device and connects
It receives the contamination condensation aerosol of controlled concentration and is stirred evenly by mixing fan, several neck seal windows for cabin of contaminating can be close
The neck that envelope fixes more dog porcine experimental animals extend into contamination cabin by its head and nose while receiving sucking dye
Poison is tested, and the concentration sample mouth by neck seal window can acquire the concentration of measurement contamination aerosol, the following separation of contamination cabin
Threeway discharges contamination exhaust gas by pneumatic filter and exhaust pump, and the contamination waste liquid in waste liquid chamber is by manual water valve and discharges water
Mouth discharge, cabin bracket support contamination cabin and adjustable height are to adapt to operator's completion Inhalation experiment.
The beneficial effects of the invention are as follows a kind of dog porcine head nose formula Inhalation device is developed, solves the experiment of dog porcine
Animal is not easy to carry out the technical problem of Inhalation experiment, and providing one kind can facilitate the fixed more dog porcines experiment of sealing dynamic
Object neck carries out an experimental provision for nose formula Inhalation simultaneously, incites somebody to action in respiratory disease pathology and medicament research and development scientific research
To extensive use.
Detailed description of the invention
Attached drawing 1 is a kind of structural schematic diagram of dog porcine head nose formula Inhalation device of the present invention
In figure
1. atomising device 2., which dilutes tracheae 3., is atomized atomization 6. dilution flow meter 7. of the flow valve atomization of 4. dilution flow rate valve 5. of tracheae
Flowmeter
8. 9. exhaust outlet of inlet manifold, 10. 14. liquid inlet suction pipe of careful 11. filter layer of layer 12. adsorption layer, 13. coarse net layer, 15. feed liquor
Metering pump
16. 17. flask for medicinal preparations of medicament, 18. pneumatic filter, I 19. air inlet, 20. air inlet air pump, 21. neck seal window, 22. spiral shell of contaminating
Silk mouth
23. concentration sample mouth 24 seals the exhaust of 26. closing handle of soft 25. cabin bracket of mouth, 27. pneumatic filter II 28.
Pump
29. 32. dewatering outlet of fixation clip 30. exhaust manifold, 31. waste liquid chamber, 33. manual water valve 34. separates the lower vertebra of threeway 35.
Body
36. movable supporting leg 37. is kept a foothold, 38. branch pipes 39. of keeping a foothold adjust the lower neck of 40. pivot flange of sleeve, 41. rack beam 42.
Portion's soft board
43. 47. main nacelle 48. of neck soft board mixes fan 49. and contaminates on 44. locking bolt of pressing plate sliding slot, 45. movable pressing board 46.
Malicious cabin
50. 51. diffuser of centrum, 52. dispatch tube, 53. mixed cabin, 54. atomizer 55. dilutes spray head on.
Specific embodiment
A kind of dog porcine head nose formula Inhalation apparatus structure of the invention is illustrated in conjunction with attached drawing 1 and embodiment.
As shown in Fig. 1, the present invention provides a kind of dog porcine head nose formula Inhalation device, which includes one in cabin
The contamination cabin 49 installed on body support frame 25, contamination cabin 49 are that the surfaces externally and internally that is made by corrosion-resistant transparent material is smooth
Polyhedron airtight cavity, main nacelle 47 among contamination cabin 49 by several flat sheet combinations with neck seal window 21 and
At the contamination condensation aerosol that being fitted with mixing fan 48 on each plate can will go into main nacelle 47 stirs equal
It is even, it is fitted with 22 fixing belt of screw-socket on each plate and seals the concentration sample mouth 23 of soft mouth 24 for the dye of acquisition measurement at any time
The actual concentrations numerical value of contamination condensation aerosol in malicious cabin 49, opening is gradually reduced with one in the upper end of main nacelle 47 upwards
Upper centrum 50 be tightly connected, the small opening of upper 50 upper end of the centrum diffuser downward with a horn mouth of atomising device 1 again
51 airtight connections, atomising device 1 are the atomizer 54 and dilution spray head 55 and atomization flow valve 5 by installing in mixed cabin 53
With the dedicated aerosol atomizing generator of atomization flowmeter 7, dilution flow rate valve 4 and 6 component of dilution flow meter composition, one is held
Have illicit sexual relations toxicant 16 flask for medicinal preparations 17 in be placed with liquid inlet suction pipe 14, persistently provide the contamination of doses by feed liquor metering pump 15
Medicament 16 arrives atomizer 54, and the high pressure gas that air inlet air pump 20 generates is divided after pneumatic filter I18 purification by inlet manifold 8
It flows one and provides atomization gas source to atomizer 54 under the control of atomization flow valve 5 and atomization flowmeter 7 to atomization tracheae 3,
Inlet manifold 8 shunts another and gives dilution spray head 55 under the control of dilution flow rate valve 4 and dilution flow meter 6 to dilution tracheae 2
Dilution gas source is provided, mixed cabin 53 is the band that is made by the firm corrosion-resistant smooth transparent material easy to clean of surfaces externally and internally
Have a sealing container of dispatch tube 52 and diffuser 51, the circular hole there are two small diameter is opened on the right of mixed cabin 53, by this two
A circular hole sealing is installed with atomizer 54 and dilutes spray head 55, the circular hole for being provided with a small diameter below of mixed cabin 53,
The liquid inlet suction pipe 14 with feed liquor metering pump 15 is installed by the sealing of this circular hole to be connected on atomizer 54, a left side for mixed cabin 53
While being provided with a larger-diameter circular hole is tightly connected the dispatch tube 52 of an elbow sample and the diffuser that a horn mouth is downward
51, the 50 top airtight connection of upper centrum of the downward diffuser 51 of horn mouth and contamination cabin 49, atomizer 54 and dilution are sprayed
The contamination condensation aerosol of first 55 formation controlled concentration is transported to contamination cabin 49 to dog pig by dispatch tube 52 and diffuser 51
Class experimental animal carries out the experiment of head nose formula Inhalation；The lower end of main nacelle 47 and another downward lower vertebra that opening is gradually reduced
Body 35 is tightly connected, the small opening of 35 lower end of hypocentrum again with separate 34 upper opening airtight connection of threeway discharge exposure experiment
The waste liquid generated is condensed during contamination condensation aerosol exhaust gas and exposure experiment；The main nacelle 47 for cabin 49 of contaminating receives atomization
The contamination condensation aerosol for the controlled concentration that device 1 is formed enters in main nacelle 47, and main nacelle 47 has neck by several
The flat sheet combination of hermetyic window 21 forms, and neck seal window 21 is the work being made by light solid corrosion-resistant surface lubricious material
Dynamic mechanical device is provided with a square aperture in the plane middle of main nacelle 47, and square aperture seals one band of installation below
The fixation clip 29 for the semicircular indentations opened upwards, inlaying low portion of neck soft board 42 on the semicircular indentations of fixation clip 29 can
Sealing function is played below to its neck in the neck of fixed dog porcine experimental animal, square aperture two sides are symmetrically installed with one
The pressing plate sliding slot 43 of locking bolt 44 is had to top, and the work for the semicircular indentations that a band is opened downwards is inserted in pressing plate sliding slot 43
Dynamic pressure plate 45, inlay on the semicircular indentations of movable pressing board 45 go up neck soft board 46 can be in fixed dog porcine experimental animal
Sealing function is played to its neck top when neck, it is real that the up and down adjustment in pressing plate sliding slot 43 of movable pressing board 45 fixes well dog porcine
Test behind the position of the neck of animal tighten locking bolt 44 movable pressing board 45 is fixed on it is motionless in pressing plate sliding slot 43；Several necks
Portion's hermetyic window 21 fixes the neck of more dog porcine experimental animals, its head is extend among contamination cabin 49 while being received
Head nose formula Inhalation experiment, mixing fan 48 is each fitted on the plate with neck seal window 21 will go into
Contamination condensation aerosol in main nacelle 47 stirs evenly, and is fitted with screw-socket on each plate with neck seal window 21
22 fixing belts seal the concentration sample mouth 24 of soft mouth 24, and concentration sample mouth 24 is used to the dye in the contamination cabin 49 of acquisition measurement at any time
The actual concentrations numerical value of malicious condensation aerosol；The hypocentrum 35 that opening is gradually reduced downwards with another for the lower end of main nacelle 47 is close
Envelope connection, again with the upper opening airtight connection that separates threeway 34, separation threeway 34 is sealing peace for the small opening of hypocentrum lower end
The a set of gas-liquid separation device that by firm resistant material is made following mounted in the hypocentrum 35 of contamination cabin 49, separation
34 top of threeway has an opening and the following opening of the hypocentrum 35 of contamination cabin 49 to be tightly connected, and separates in 34 side of threeway
Portion has an opening to be tightly connected with the exhaust manifold 30 for being connected to pneumatic filter II 27 and exhaust pump 28, can be vented
Pump 28 swabbing action under by contaminate cabin 49 in contamination condensation aerosol exhaust gas by pneumatic filter II 27 filtering and
What is exported after absorption has been that innoxious clean gas emits, and separation threeway 34 is connected with waste liquid chamber 31 below, can be with
The waste liquid generated is condensed during storage exposure experiment, 31 bottom of waste liquid chamber has an opening to pass through a manual water valve 33 and put
The mouth of a river 32 is tightly connected, and condensation generates useless during the contamination that can will be stored in waste liquid chamber 31 when pulling open manual water valve 33
Liquid discharge is clean；Pneumatic filter I 18 and pneumatic filter II 27 is rear end and the exhaust for being respectively arranged in air inlet air pump 20
The special equipment for being used to purify the gaseous impurity passed through of 28 front ends is pumped, the both ends of pneumatic filter I 18 are respectively provided with one respectively
Nozzle, what is connect with air inlet air pump 20 is air inlet 19, and connection inlet manifold's 8 is exhaust outlet 9, and pneumatic filter I 18 is gentle
The shell of body filter II 27 is the airtight cavity that a rigid, corrosion resistant material is made, and airtight cavity is interior from air inlet
19 successively arrange the coarse net layer 13 that useful multiple compact metal net is made to exhaust outlet 9, carries in gas for intercepting
Large particle and fiber impurity, the adsorption layer 12 that useful activity Carbon Materials are made are various for what is contained in adsorbed gas
Organic impurities, the filter layer 11 that useful specialty fibers material is made, for filtering various fine contained in gas
Grain impurity, the careful layer 10 that useful high molecular material is made are miscellaneous for adsorbing the various microorganisms contained in shroud gas
Matter, by pneumatic filter I 18 and pneumatic filter II 27 filtering and absorption output be innoxious pure gas
Body；Contamination cabin 49 is placed on experiment room floor by the way that a cabin bracket 25 is stable, and cabin bracket 25 is held by firm
What weight rigid material was made is firmly fixed the complex mechanical mechanisms for being supported on contamination 49 lower surface of cabin, in its top
It is that the quadrangle of closure quadrangle is equipped with the rack beam 41 of pivot flange 40, the following of each pivot flange 40 is vertically consolidated
A fixed movable supporting leg 36, the lower end of each movable supporting leg 36 is cased with one section of adjusting sleeve 39, each 39 side of adjusting sleeve
It is upper to be all fixed with closing handle 26 again, when unclamping closing handle 26, it will be able to change the insertion of movable supporting leg 36 and adjust sleeve
Length between 39 also just changes the height of movable supporting leg 36, when tightening closing handle 26, the height of movable supporting leg 36
Degree be fixed it is motionless, each adjust sleeve 39 lower end connect one with keep a foothold 37 branch pipe 38 of keeping a foothold, can be stable
It is placed on experiment room floor, by adjusting the height of the movable supporting leg 36 of quadrangle, it will be able to which free adjustment up and down is entire
The height for cabin 49 of contaminating is tested with the completion Inhalation for adapting to operator's safe ready.
Embodiment:
It should first have to before being tested using a kind of dog porcine head nose formula Inhalation device of the present invention according to operator's
Demand adjusts the height of dog porcine head nose formula Inhalation device, first unclamps the closing handle 26 adjusted on sleeve 39, then
Change the length between the insertion adjusting sleeve 39 of movable supporting leg 36 to desired value, also just changes the height of movable supporting leg 36
Degree, then tightens closing handle 26, the height of movable supporting leg 36 be just adjusted it is fixed, then again with same method
It is sequentially adjusted in the height of other 3 movable supporting legs 36, guarantees four movable supporting legs 36 in sustained height, each adjusting set
Cylinder 39 lower end connect one with keep a foothold 37 branch pipe 38 of keeping a foothold, can be stable be placed in experiment room floor on, in this way tune
The height of whole good entire contamination cabin 49 is tested with the completion Inhalation for adapting to operator's safe ready；It is then ready for reality
The required contamination medicament 16 used when testing, it is poured into flask for medicinal preparations 17 according to requirement of experiment, is ready to do the dog pig tested
Class experimental animal and suitable fixation clip 29, low portion of neck soft board 42, movable pressing board 45 and upper neck soft board 46, in main nacelle 47
Plane middle square aperture on install the fixation clips 29 of the semicircular indentations that the band of preparation is opened upwards, then solid
Inlayed on the semicircular indentations of fixed pressuring plate 29 low portion of neck soft board 42 so as in the neck of fixed dog porcine experimental animal to it
Neck plays sealing function below, pacifies the dog porcine experimental animal of experiment now and it is allowed quietly to stand in main nacelle 47
Plane middle square aperture before, unclamp the locking bolt 44 on the pressing plate sliding slot 43 that is symmetrically installed of square aperture two sides,
The movable pressing board 45 for the semicircular indentations that band is opened downwards is inserted into pressing plate sliding slot 43, and then the semicircle of movable pressing board 45 is lacked
Neck soft board 46 is inlayed on mouth to make to play sealing to its neck top in the neck of fixed dog porcine experimental animal
With, the head of experimental animal is extend among contamination cabin 49, it is then that movable pressing board 45 is upper in pressing plate sliding slot 43 to lower
It saves and tightens locking bolt 44 behind the position of the neck of fixed dog porcine experimental animal movable pressing board 45 is fixed on pressing plate sliding slot
It is motionless in 43；It according to experiment needs that more dog porcines can be fixed by several neck seal windows 21 using above method real
The neck for testing animal extend into their head among contamination cabin 49；Connect contamination cabin 49, feed liquor metering pump 15, into
The power supply of gas air pump 20 and exhaust pump 28, the liquid inlet suction pipe 14 being contained in the flask for medicinal preparations 17 of contamination medicament 16, passes through feed liquor meter
The contamination medicament 16 that amount pump 15 persistently provides doses arrives atomizer 54, and the high pressure gas that air inlet air pump 20 generates is through gas
One is shunted to atomization tracheae 3 in atomization flow valve 5 and atomization flowmeter 7 by inlet manifold 8 after the purification of 18 multilayer of filter I
Control under give atomizer 54 provide atomization gas source, inlet manifold 8 shunt another to dilution tracheae 2 in dilution flow rate valve 4
Dilution spray head 55 is given to provide dilution gas source under control with dilution flow meter 6, atomizer 54 and dilution spray head 55 are formed controllably
The contamination condensation aerosol of concentration is transported to contamination cabin 49, the main nacelle for cabin 49 of contaminating by dispatch tube 52 and diffuser 51
The contamination condensation aerosol for the controlled concentration that 47 reception atomising devices 1 are formed enters in main nacelle 47, each of main nacelle 47
The contamination condensation aerosol that mixing fan 48 on plate will go into main nacelle 47 stirs evenly, several neck seal windows
21 securing more dogs porcine experimental animals start simultaneously at the experiment of accepting header nose formula Inhalation, and the concentration on each plate is adopted
Sample mouth 23 acquires the actual concentrations numerical value of the contamination condensation aerosol in measurement contamination cabin 49 at any time；During exposure experiment,
Being sealingly mounted at the separation threeway 34 of the hypocentrum 35 of contamination cabin 49 below at any time will dye under the swabbing action of exhaust pump 28
Multiple filtration and absorption of the contamination condensation aerosol exhaust gas that exposure experiment generates in malicious cabin 49 by pneumatic filter II 27
What is exported afterwards has been that innoxious clean gas emits；The storage contamination of waste liquid chamber 31 that separation threeway 34 connects below is real
The opening of the waste liquid that condensation generates during testing, 31 bottom of waste liquid chamber is connected by a manual water valve 33 and the sealing of dewatering outlet 32
It connects, when needing to discharge waste liquid, will be condensed during the contamination stored in waste liquid chamber 31 when pulling open manual water valve 33 through dewatering outlet
The discharging of waste liquid of generation is clean；After the completion of experiment, the locking on the pressing plate sliding slot 43 that square aperture two sides are symmetrically installed is unclamped again
Bolt 44 is lifted up movable pressing board 45 out of pressing plate sliding slot 43, sealing fixed dog porcine experimental animal when unclamping experiment
Neck, the head of experimental animal is released from contamination cabin 49, it is sliding that movable pressing board 45 then turned back to pressing plate again
Locking bolt 44 is tightened in slot 43 movable pressing board 45 is fixed in pressing plate sliding slot 43, remaining contamination medicament 16 has been collected guarantor
It retains to do and use next time, whole cleaning and disinfection are done to contamination cabin 49, by contamination condensation aerosol exhaust gas and experimental waste liquid
All discharge is clean, be then turned off contamination cabin 49, feed liquor metering pump 15, air inlet air pump 20 and exhaust pump 28 power supply, experiment
Animal, which is sent to, does further scientific analysis and research.
Claims (8)
1. a kind of dog porcine head nose formula Inhalation device is pacified on cabin bracket (25) it is characterized in that: the device includes one
The upper centrum of opening is gradually reduced with one upwards for the contamination cabin (49) of dress, the upper end of the main nacelle (47) of contamination cabin (49)
(50) it is tightly connected, the small opening of upper centrum (50) upper end and the diffuser downward with a horn mouth of atomising device (1)
(51) airtight connection, the contamination condensation aerosol for receiving the controlled concentration that atomising device (1) is formed enter in main nacelle (47),
The intermediate main nacelle (47) of contamination cabin (49) is formed by several flat sheet combinations with neck seal window (21), several necks
Portion's hermetyic window (21) can fix the neck of more dog porcine experimental animals, and it is intermediate that its head is extend into contamination cabin (49)
Accepting header nose formula Inhalation experiment simultaneously, being each equipped with mixing fan (48) on the plate with neck seal window (21) can
It is stirred evenly with the contamination condensation aerosol that will go into main nacelle (47), on each plate with neck seal window (21)
It is fitted with the concentration sample mouth (24) that screw-socket (22) fixing belt seals soft mouth (24), concentration sample mouth (24) is used to adopt at any time
Collection measurement contamination cabin (49) in contamination condensation aerosol actual concentrations numerical value, the lower end of main nacelle (47) and another to
Under the hypocentrum (35) of opening be gradually reduced be tightly connected, the small opening of hypocentrum lower end is opened with the top for separating threeway (34) again
Mouth airtight connection, separation threeway (34) middle side edge have an opening and are connected to pneumatic filter II(27) and exhaust pump (28)
Exhaust manifold (30) be tightly connected, can under the swabbing action of exhaust pump (28) will contaminate cabin (49) in contamination atomization
What aerosol exhaust gas exported after the filtering and absorption of pneumatic filter (27) has been that innoxious clean gas gives off
It goes, separation threeway (34) has a waste liquid chamber (31) below, can store the waste liquid of condensation generation during exposure experiment, waste liquid
Room (31) bottom has an opening to be tightly connected by a manual water valve (33) and dewatering outlet (32), is pulling open manual water valve
(33) can be clean by the discharging of waste liquid for condensing generation during the contamination stored in waste liquid chamber (31) when, contamination cabin (49) is logical
It crosses stable being placed in of a cabin bracket (25) to test on room floor, and the height of the movable supporting leg (36) by adjusting quadrangle
Degree, it will be able to the height of entire contamination cabin (49) is adjusted above and below free to adapt to the completion sucking of operator's safe ready
Exposure experiment.
2. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the contamination cabin
It (49) is the smooth polyhedron airtight cavity of surfaces externally and internally that is made by corrosion-resistant transparent material, among contamination cabin (49)
Main nacelle (47) is formed by several flat sheet combinations with neck seal window (21), and mixing fan is equipped on each plate
(48) the contamination condensation aerosol that can be will go into main nacelle (47) stirs evenly, and is fitted with screw-socket on each plate
(22) the concentration sample mouth (23) that fixing belt seals soft mouth (24) is used to contamination atomization in acquisition measurement contamination cabin (49) at any time
The actual concentrations numerical value of aerosol, upper centrum (50) sealing that opening is gradually reduced with one in the upper end of main nacelle (47) upwards connect
It connects, the small opening of upper centrum (50) upper end and diffuser (51) airtight connection downward with a horn mouth of atomising device (1),
The lower end of main nacelle (47) and another hypocentrum (35) that opening is gradually reduced downwards are tightly connected, hypocentrum (35) lower end
It is small opening again with separate threeway (34) upper opening airtight connection discharge exposure experiment contamination condensation aerosol exhaust gas and contamination
The waste liquid of generation is condensed in experimentation.
3. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the separation threeway
(34) be sealingly mounted at contamination cabin (49) hypocentrum (35) it is following be made by firm resistant material it is a set of
Gas-liquid separation device, separation threeway (34) top have an opening and the opening below of the hypocentrum (35) of contamination cabin (49) close
Envelope connection, separation threeway (34) middle side edge have one opening be connected to pneumatic filter II(27) and exhaust pump (28) give up
Gas comb (30), which is tightly connected, is used to discharge exhaust gas, and separation threeway (34) is connected with waste liquid chamber (31) below, waste liquid chamber (31) bottom
Portion has an opening to be tightly connected by a manual water valve (33) and dewatering outlet (32) for waste discharge.
4. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the neck seal window
It (21) is the mobile machine device being made by light solid corrosion-resistant surface lubricious material, in the main cabin of contamination cabin (49)
The plane middle of body (47) is provided with a square aperture, and square aperture seals the semicircle that one band of installation is opened upwards below and lacks
Mouthful fixation clip (29), low portion of neck soft board (42) is inlayed on the semicircular indentations of fixation clip (29) can be in fixed dog pig
Sealing function is played below to its neck when the neck of class experimental animal, square aperture two sides are symmetrically installed with a pair of of top and have
The pressing plate sliding slot (43) of locking bolt (44), the interior activity pressure for being inserted with the semicircular indentations that a band is opened downwards of pressing plate sliding slot (43)
Plate (45), inlay on the semicircular indentations of movable pressing board (45) go up neck soft board (46) can be in fixed dog porcine experimental animal
Neck when sealing function played to its neck top, movable pressing board (45) fixes well dog in pressing plate sliding slot (43) interior up and down adjustment
It tightens locking bolt (44) behind the position of the neck of porcine experimental animal movable pressing board (45) is fixed in pressing plate sliding slot (43)
It is motionless.
5. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the atomising device
It (1) is by the atomizer (54) of installation in mixed cabin (53) and dilution spray head (55) and atomization flow valve (5) and atomized flow
The dedicated aerosol atomizing generator of meter (7), dilution flow rate valve (4) and dilution flow meter (6) component composition, one is contained with
Liquid inlet suction pipe (14) are placed in the flask for medicinal preparations (17) of contamination medicament (16), persistently provide doses by feed liquor metering pump (15)
Contamination medicament (16) arrive atomizer (54), air inlet air pump (20) generate high pressure gas through pneumatic filter I(18) purify
One is shunted by inlet manifold (8) afterwards to give under the control of atomization flow valve (5) and atomization flowmeter (7) to atomization tracheae (3)
Atomizer (54) provides atomization gas source, inlet manifold (8) shunt another to dilution tracheae (2) in dilution flow rate valve (4) and
Dilution spray head (55) is given to provide dilution gas source, the atomizer being mounted in mixed cabin (53) under the control of dilution flow meter (6)
(54) it is conveyed with the contamination condensation aerosol of dilution spray head (55) formation controlled concentration by dispatch tube (52) and diffuser (51)
Inhalation experiment is carried out to dog porcine experimental animal to contamination cabin (49).
6. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the mixed cabin (53)
It is that one is made by the firm corrosion-resistant smooth transparent material easy to clean of surfaces externally and internally with dispatch tube (52) and diffuser
(51) sealing container opens the circular hole there are two small diameter on the right of mixed cabin (53), passes through the sealing installation of the two circular holes
Atomizer (54) and dilution spray head (55), mixed cabin (53) be provided with the circular hole of a small diameter below, pass through this
Circular hole sealing is installed with the liquid inlet suction pipe with feed liquor metering pump (15) (14) and is connected on atomizer (54), a left side for mixed cabin (53)
While being provided with a larger-diameter circular hole is tightly connected the dispatch tube (52) of an elbow sample and the diffusion that a horn mouth is downward
It manages (51), upper centrum (50) top airtight connection of the downward diffuser of horn mouth (51) and contamination cabin (49).
7. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the pneumatic filter
I(18) and pneumatic filter II(27) be respectively arranged in air inlet air pump (20) rear end and exhaust pump (28) front end be used to it is net
Change the special equipment of gaseous impurity passed through, pneumatic filter I(18) both ends be respectively provided with a nozzle respectively, with air inlet air pump
(20) connection is air inlet (19), and connection inlet manifold (8) is exhaust outlet (9), pneumatic filter I(18) and gas filtration
Device II(27) shell be airtight cavity that a rigid, corrosion resistant material is made, in airtight cavity from air inlet (19) to
Exhaust outlet (9) successively arranges the coarse net layer (13) that useful multiple compact metal net is made, and carries in gas for intercepting
Large particle and fiber impurity, the adsorption layer (12) that useful activity Carbon Materials are made are each for what is contained in adsorbed gas
Kind of organic impurities, the filter layer (11) that useful specialty fibers material is made, for filter contain in gas it is various micro-
Fine grained impurity, the careful layer (10) that useful high molecular material is made, for adsorb contain in shroud gas it is various micro-
Biological impurities, by pneumatic filter I(18) and pneumatic filter II(27) filtering and absorption output be innoxious
Clean gas.
8. a kind of dog porcine head nose formula Inhalation device according to claim 1, it is characterized in that: the cabin bracket
(25) it is compounding machine that being firmly fixed of being made by firm load-bearing rigid material is supported on contamination cabin (49) lower surface
Tool device is that the quadrangle of closure quadrangle is equipped with the rack beam (41) of pivot flange (40) in its top, each branch
Staying orchid (40) vertically fixes a movable supporting leg (36) below, and the lower end of each movable supporting leg (36) is cased with one section
It adjusts sleeve (39), is fixed with closing handle (26) again on each adjusting sleeve (39) side, when unclamping closing handle (26),
The length between movable supporting leg (36) insertion adjusting sleeve (39) can be changed, also just change movable supporting leg (36)
Highly, when tightening closing handle (26), the height of movable supporting leg (36) is fixed motionless, each adjusts sleeve (39)
Lower end connects one with the branch pipe of keeping a foothold (38) of (37) of keeping a foothold, can be stable be placed on experiment room floor.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811390724.6A CN109350300B (en) | 2018-11-21 | 2018-11-21 | Nose-head inhalation contamination device for dogs and pigs |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811390724.6A CN109350300B (en) | 2018-11-21 | 2018-11-21 | Nose-head inhalation contamination device for dogs and pigs |
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| CN109350300B CN109350300B (en) | 2024-05-28 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111888044A (en) * | 2020-07-24 | 2020-11-06 | 山西医科大学第一医院 | Atomization drug delivery device for experimental animals |
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| CN206266597U (en) * | 2016-11-18 | 2017-06-20 | 天津开发区合普工贸有限公司 | Tissue Culture Dish bacterium infection experimental provision |
| CN209864165U (en) * | 2018-11-21 | 2019-12-31 | 天津开发区合普工贸有限公司 | Dog and pig head nose type inhalation contamination device |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389339A (en) * | 2011-07-06 | 2012-03-28 | 天津开发区合普工贸有限公司 | Only-nose inhaling poison exposure experimental equipment for rodent |
| CN106434303A (en) * | 2016-11-18 | 2017-02-22 | 天津开发区合普工贸有限公司 | Bacterial infection experiment device for cell culture dishes |
| CN206266597U (en) * | 2016-11-18 | 2017-06-20 | 天津开发区合普工贸有限公司 | Tissue Culture Dish bacterium infection experimental provision |
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| CN111888044A (en) * | 2020-07-24 | 2020-11-06 | 山西医科大学第一医院 | Atomization drug delivery device for experimental animals |
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