CN111888044A

CN111888044A - Atomization drug delivery device for experimental animals

Info

Publication number: CN111888044A
Application number: CN202010722947.9A
Authority: CN
Inventors: 庞敏; 王海龙; 郭民; 李婷; 王维; 李奔; 刘超峰; 孙佳; 王文桃; 刘跃华; 秦轲茹; 胡金瑞; 栗馨洋; 徐白雪; 于保锋; 刘红丽; 孟晓丽
Original assignee: First Hospital of Shanxi Medical University
Current assignee: First Hospital of Shanxi Medical University
Priority date: 2020-07-24
Filing date: 2020-07-24
Publication date: 2020-11-06

Abstract

The invention belongs to the technical field of animal experiment equipment, and particularly relates to an atomization drug delivery device for experimental animals. The invention is based on clinical practice, simulates clinical oral atomization administration, and has closer research conclusion to clinical application and more practical significance.

Description

Atomization drug delivery device for experimental animals

Technical Field

The invention belongs to the technical field of animal experiment equipment, and particularly relates to an atomization drug delivery device for an experimental animal.

Background

The aerosol inhalation of experimental animals is an important means for constructing respiratory system experimental animal models and carrying out research on medicaments and pharmacology related to respiratory system diseases. In clinical practice, the atomization administration to the respiratory system is carried out in an oral inhalation mode, so that the respiratory intensity can be increased, and the medicament can more easily reach the bronchus and the terminal bronchiole, thereby achieving the best treatment effect. In the prior art, the atomization administration of experimental animals is to fix the whole body, and the experimental animals are inhaled through a mask and a nasal cavity, so that the problems of large difference from clinical practice, low inhalation amount and low inhalation speed are caused.

Disclosure of Invention

The invention provides an atomization drug delivery device for experimental animals aiming at the problems.

In order to achieve the purpose, the invention adopts the following technical scheme:

the atomization drug delivery device for the experimental animals comprises an atomizer and a dispersion container, wherein the atomizer is arranged on the lower surface of the dispersion container and communicated with the dispersion container and used for conveying atomized gas into the dispersion container, a sealing end cover is arranged at the upper end of the dispersion container, a plurality of ventilation hoses are uniformly connected onto the side wall of the dispersion container, the tail end of each ventilation hose is divided into two branches, a ventilation hard pipe is connected to the tail end of each branch, the tail ends of the two ventilation hard pipes are oppositely arranged, a spring sheet is arranged between the two ventilation hard pipes to form a stethoscope structure, a plurality of outward-facing air outlet holes are formed in the side surface of the tail end of each ventilation hard pipe, a head fixing sleeve is arranged at the tail part of each ventilation hard pipe and can be spliced into a complete conical shell, and a base is arranged below each ventilation hard pipe, the base is provided with a fixing table for fixing the ventilation hard tube, one side of the opening of the head fixing sleeve is provided with a neck fixing piece, and the neck fixing piece is installed on the upper surface of the base.

Further, the neck fixing piece comprises a fastening belt and two upright posts which are symmetrically arranged on the base in a left-right manner, a sliding groove in the vertical direction is arranged on the upright post, a sliding block is arranged in the sliding groove, a screw is connected with the sliding block in a threaded manner to fix the sliding block, the slide block is also fixedly connected with a limiting block, the limiting block is provided with a sliding pore channel in the left-right direction, a movable rod is arranged in the sliding pore channel, a connecting block is arranged at the inner side end of the movable rod, a lifting hole is arranged between the two upright posts on the base, a lifting rod is movably arranged in the lifting hole, arc-shaped connecting sleeves are arranged on the connecting block and the lifting rod, the fastening belt sequentially passes through the three arc-shaped connecting sleeves, one end of the fastening belt is fixedly connected with the belt buckle, and the other end of the fastening belt penetrates through the belt buckle to realize the tightening or loosening of the fastening belt.

And furthermore, a motor is fixedly arranged in the middle of the sealing end cover, and a plurality of vertically arranged blades are arranged on an output shaft of the motor so as to uniformly disperse the gas sent into the dispersing container by the atomizer to the periphery, so that the gas dispersed into each ventilating hose is uniform as much as possible.

Still further, the dispersion container is connected with the air hose through a conical transition pipe, so that gas dispersed by the blades can be better sent into the air hose.

Still further, the conical transition pipe is arranged in an inclined mode, and the inclined direction of the conical transition pipe is the same as the rotating direction of the blades.

Still further, the fixed station includes that bilateral symmetry sets up two threaded rods on the base be provided with two nuts on the threaded rod, two the joint movement cover is equipped with two splint on the threaded rod, just two splint are located between two nuts, the hard tube that ventilates sets up between two splint.

And a sponge layer is arranged on the inner side of the arc-shaped connecting sleeve.

Compared with the prior art, the invention has the following advantages:

1. based on clinical practice, in the preparation of experimental animal models and the pharmacological research of drugs, the head of an experimental animal is fixed through the head fixing sleeve, the atomized gas is directly conveyed into the mouth of the animal through the ventilating hard tube, the clinical oral atomization administration is simulated, the research conclusion is closer to the clinic and the practical significance is achieved, meanwhile, the air outlet hole in the ventilating hard tube is formed towards the throat part of the animal, the inhalation volume of the animal is directly increased, the waste of drugs is avoided, and the experimental efficiency is improved;

2. compared with the whole-body fixation in the existing atomization device, the neck fixing piece and the head fixing sleeve are used for fixing the animal, the neck fixing piece and the head fixing sleeve utilize the instinct that the animal wants to take off, and the animal struggles after the neck is fixed, so that the amount of exercise of the animal is increased, and the amount of medicine sucked by the animal is increased.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic diagram of the construction of the present invention without the atomizer and the dispersion vessel;

FIG. 3 is a schematic view of a stethoscope constructed with a flexible air tube and a rigid air tube according to the present invention;

FIG. 4 is a schematic view of the structure of the fixing table and the neck fixing member of the present invention;

FIG. 5 is a schematic diagram of the construction of an atomizer and dispersion vessel according to the present invention;

in the figure, an atomizer-1, a dispersion container-2, a sealing end cover-3, a ventilation hose-4, a ventilation hard tube-5, a spring sheet-6, an air outlet-7, a fixed platform-8, a neck fixing piece-9, a head fixing sleeve-10, a base-11, a motor-12, a blade-13, a conical transition tube-14, a threaded rod-801, a nut-802, a clamping plate-803, a fastening belt-901, a stand column-902, a sliding chute-903, a sliding block-904, a limiting block-906, a sliding hole channel-907, a movable rod-908, a connecting block-909, a lifting hole-910, a lifting rod-911, an arc connecting sleeve-912 and a belt fastener-913 are arranged.

Detailed Description

In order to further illustrate the technical solution of the present invention, the present invention is further illustrated by the following examples.

As shown in fig. 1 to 5, the atomizing medicine feeding device for experimental animals comprises an atomizer 1 and a dispersing container 2, wherein the atomizer 1 is arranged on the lower surface of the dispersing container 2, the atomizer 1 is communicated with the dispersing container 2 and is used for conveying atomized gas into the dispersing container 2, a sealing end cover 3 is arranged at the upper end of the dispersing container 2, a motor 12 is fixedly arranged in the middle of the sealing end cover 3, and a plurality of vertically arranged blades 13 are arranged on an output shaft of the motor 12 so as to uniformly disperse the gas fed into the dispersing container 2 by the atomizer 1 to the periphery, so that the gas dispersed into each ventilating hose 4 is uniform as much as possible. A plurality of air hoses 4 are uniformly connected to the side wall of the dispersion container 2, and the dispersion container 2 and the air hoses 4 are connected through a tapered transition pipe 14, so that the gas dispersed by the blades 13 can be better sent into the air hoses 4. The tapered transition pipe 14 is arranged in an inclined manner, and the inclined direction of the tapered transition pipe 14 is the same as the rotating direction of the blades 13. The tail end of the ventilation hose 4 is divided into two branches, the tail end of each branch is connected with a ventilation hard tube 5, the tail ends of the two ventilation hard tubes 5 are arranged oppositely, a spring piece 6 is arranged between the two ventilation hard tubes 5 to form a stethoscope structure, a plurality of outward air outlet holes 7 are arranged on the side surface of the tail end of the ventilation hard tube 5, a head fixing sleeve 10 is arranged at the tail part of the ventilation hard tube 5, the two head fixing sleeves 10 can be spliced into a complete conical shell, a base 11 is arranged below the ventilation hard tube 5, a fixing table 8 for fixing the ventilation hard tube 5 is arranged on the base 11, the fixing table 8 comprises two threaded rods 801 which are symmetrically arranged on the base 11, two nuts 802 are arranged on the threaded rods 801, and two clamping plates 803 are movably sleeved on the two threaded rods 801 together, and the two clamping plates 803 are positioned between the two nuts 802, and the vent hard tube 5 is arranged between the two clamping plates 803. A neck fixing piece 9 is arranged on one side of the opening of the head fixing sleeve 10, and the neck fixing piece 9 is arranged on the upper surface of the base 11. The neck fixing part 9 comprises a fastening belt 901 and two upright posts 902 arranged on a base 11 in bilateral symmetry, wherein the upright posts 902 are provided with sliding grooves 903 in the vertical direction, the sliding grooves 903 are internally provided with sliding blocks 904, the sliding blocks 904 are in threaded connection with screws to fix the sliding blocks 904, the sliding blocks 904 are also fixedly connected with limiting blocks 906, the limiting blocks 906 are provided with sliding hole ways 907 in the left and right directions, the sliding hole ways 907 are internally provided with movable rods 908, the inner side ends of the movable rods 908 are provided with connecting blocks 909, a lifting hole 910 is arranged in the middle of the two upright posts 902 on the base 11, the lifting rods 911 are movably arranged in the lifting hole 910, the connecting blocks 909 and the lifting rods 911 are both provided with arc-shaped connecting sleeves 912, and the inner sides of the arc-shaped connecting sleeves 912 are provided with sponge layers. The fastening belt 901 sequentially penetrates through the three arc-shaped connecting sleeves 912, one end of the fastening belt 901 is fixedly connected with a belt buckle 913, and the other end of the fastening belt 901 penetrates through the belt buckle 913, so that the fastening belt 901 is tightened or loosened.

The aerosol administration device for laboratory animals according to the present embodiment can be used for general laboratory animals such as rats, mice, rabbits, guinea pigs, and small dogs.

While there have been shown and described what are at present considered to be the essential features and advantages of the invention, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. Atomizing device of dosing for laboratory animal, its characterized in that: including atomizer (1) and dispersion container (2), atomizer (1) sets up the lower surface at dispersion container (2), just atomizer (1) with dispersion container (2) intercommunication for carry the gas after atomizing to dispersion container (2) in the upper end of dispersion container (2) is provided with end cover (3) evenly be connected with a plurality of ventilation hose (4) on the lateral wall of dispersion container (2), the end of ventilation hose (4) falls into two branches, and all is connected with ventilation hard tube (5) at the end of every branch road, and the end of two ventilation hard tube (5) sets up relatively, is provided with spring leaf (6) between two ventilation hard tube (5), forms the stethoscope structure ventilation hard tube (5) terminal side be provided with a plurality of ventholes (7) towards the outside, ventilation hard tube (5)'s afterbody is provided with head fixed cover (10), the two head fixing sleeves (10) can be spliced into a complete conical shell, a base (11) is arranged below the ventilating hard tube (5), a fixing table (8) for fixing the ventilating hard tube (5) is arranged on the base (11), a neck fixing piece (9) is arranged on one side of an opening of the head fixing sleeve (10), and the neck fixing piece (9) is arranged on the upper surface of the base (11).

2. The aerosolized drug delivery apparatus for laboratory animals according to claim 1, characterized in that: the neck fixing piece (9) comprises a fastening belt (901) and two upright posts (902) which are arranged on a base (11) in a bilateral symmetry manner, a sliding groove (903) in the vertical direction is formed in each upright post (902), a sliding block (904) is arranged in each sliding groove (903), a screw is connected to each sliding block (904) in a threaded manner so as to fix each sliding block (904), a limiting block (906) is fixedly connected to each sliding block (904), a sliding hole channel (907) in the left-right direction is formed in each limiting block (906), a movable rod (908) is arranged in each sliding hole channel (907), a connecting block (909) is arranged at the inner side end of each movable rod (908), a lifting hole (910) is formed in the middle of each upright post (902) on the base (11), a lifting rod (911) is movably arranged in each lifting hole (910), and arc-shaped connecting sleeves (912) are arranged on each connecting block (909) and each lifting rod (911), the fastening belt (901) sequentially penetrates through the three arc-shaped connecting sleeves (912), one end of the fastening belt (901) is fixedly connected with a belt buckle (913), and the other end of the fastening belt (901) penetrates through the belt buckle (913) so as to achieve the tightening or loosening of the fastening belt (901).

3. The aerosolized drug delivery apparatus for laboratory animals according to claim 1, characterized in that: the middle part of the sealing end cover (3) is fixedly provided with a motor (12), and a plurality of vertically arranged blades (13) are arranged on an output shaft of the motor (12) so as to uniformly disperse the gas sent into the dispersing container (2) by the atomizer (1) to the periphery, so that the gas dispersed into each ventilation hose (4) is uniform as much as possible.

4. The aerosolized drug delivery apparatus for laboratory animals according to claim 3, characterized in that: the dispersing container (2) is connected with the ventilating hose (4) through a conical transition pipe (14) so as to better send the gas dispersed by the blades (13) into the ventilating hose (4).

5. The aerosolized drug delivery apparatus for laboratory animals according to claim 4, characterized in that: the conical transition pipe (14) is obliquely arranged, and the oblique direction of the conical transition pipe (14) is the same as the rotating direction of the blades (13).

6. The aerosolized drug delivery apparatus for laboratory animals according to claim 1, characterized in that: fixed station (8) include that bilateral symmetry sets up two threaded rods (801) on base (11) be provided with two nuts (802) on threaded rod (801), two the joint activity cover is equipped with two splint (803) on threaded rod (801), just two splint (803) are located between two nuts (802), ventilation hard tube (5) set up between two splint (803).

7. The aerosolized drug delivery apparatus for laboratory animals according to claim 1, characterized in that: a sponge layer is arranged on the inner side of the arc-shaped connecting sleeve (912).