CN111150521A - Airway drug experiment system - Google Patents

Airway drug experiment system Download PDF

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Publication number
CN111150521A
CN111150521A CN202010056507.4A CN202010056507A CN111150521A CN 111150521 A CN111150521 A CN 111150521A CN 202010056507 A CN202010056507 A CN 202010056507A CN 111150521 A CN111150521 A CN 111150521A
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CN
China
Prior art keywords
medicine
storehouse
drug
atomizer
airway
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Pending
Application number
CN202010056507.4A
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Chinese (zh)
Inventor
李豫
周琼
彭文贝
王子豪
王旭
向烜
叶淋淋
韦晓山
牛怡然
张丝雨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tongji Medical College of Huazhong University of Science and Technology
Union Hospital Tongji Medical College Huazhong University of Science and Technology
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
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Application filed by Union Hospital Tongji Medical College Huazhong University of Science and Technology filed Critical Union Hospital Tongji Medical College Huazhong University of Science and Technology
Priority to CN202010056507.4A priority Critical patent/CN111150521A/en
Publication of CN111150521A publication Critical patent/CN111150521A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A61D7/04Devices for anaesthetising animals by gases or vapours; Inhaling devices

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Catching Or Destruction (AREA)

Abstract

The invention relates to an airway drug experiment system which comprises a supporting seat, drug bins and drug delivery devices, wherein the supporting seat comprises vertically arranged supporting rods, a base and a plurality of trays, the trays are symmetrically arranged around the supporting rods by taking the supporting rods as centers, the base is arranged at the bottom ends of the supporting rods, the drug bins are arranged in the trays, the drug delivery devices comprise drug bottles, drug delivery tubes and atomizers, the number of the drug bottles is consistent with that of the trays, the drug bottles are symmetrically arranged at the top ends of the supporting rods by taking the supporting rods as centers, the atomizers are arranged on the side faces of the drug bins, each drug bottle is connected with the atomizers through the drug delivery tubes, and the supporting rods are provided with controllers of the atomizers. The invention is used for carrying out different drug administration on a plurality of experimental animals simultaneously in an airway drug experiment, effectively improves the experimental efficiency, enables the animals to uniformly inhale the drugs and ensures the accurate experimental result.

Description

Airway drug experiment system
The technical field is as follows:
the invention relates to the technical field of animal experiments, in particular to an airway drug experiment system.
Background art:
animal experiment is the means that medical science medicine experiment is commonly used, to some medicines of being applied to the air flue, medicine such as treatment asthma and airway inflammation, animal air flue experiment often needs to be carried out, the artifical nasal cavity department that toward experimental animal of adopting of present air flue medicine research mostly drips the medicine, by the passive inspiratory method of experimental animal again, also there are some auxiliary assembly at present and can help the experimenter to administer to the animal, the patent for ZL201821342393.4 can avoid causing the damage when can making injecting the mouse oral cavity through setting up rubber circle and gasbag in hollow fixed intraductal, and can strut the mouse oral area, thereby conveniently administer, in addition still set up movable tube and spout and can make and adjust the length when injecting as required, thereby be convenient for master the precision of dosing. However, whether the artificial nasal drop or the auxiliary oral administration is carried out, the following defects exist: 1. the experimental animal passively inhales the medicine, so that the medicine cannot uniformly act on the respiratory tract, deviation of experimental results is caused, and the behavior change condition of the experimental animal in the medicine treatment process cannot be observed; 2. one experimenter cannot simultaneously perform a plurality of groups of operations with different concentrations, different dosages and different action times, and when the number of experimental animals is large, the experimenter cannot quickly complete the experiment operation, which wastes time and labor; 3. the experimenter operates with bare hands, the experimenter is easily scratched by the experimental animal, and some substances with high toxicity are directly contacted by the experimenter and act on the experimenter, so that certain potential safety hazards exist.
The invention content is as follows:
technical problem to be solved
The invention aims to provide an airway drug experiment system, which is used for airway drug experiments and solves the problems that experimental result deviation is easily caused in the existing airway drug experiments, one experimenter cannot simultaneously perform multiple groups of operations, time and labor are wasted in operation when a plurality of experimental animals are in use, the behavior change condition of the experimental animals cannot be observed, and potential safety hazards such as injury or poisoning exist in the experimenter.
The technical scheme is as follows:
in order to solve the technical problems, the invention adopts the following technical scheme: an airway drug experiment system comprises a supporting seat, a drug bin and a drug delivery device, wherein the supporting seat comprises a supporting rod, a base and a plurality of trays which are vertically arranged, the supporting rods are symmetrically arranged around the supporting rods by taking the supporting rods as the center, the base is arranged at the bottom ends of the supporting rods, the medicine bin is arranged in each tray, the drug delivery device comprises drug bottles, drug delivery tubes and atomizers, the number of the drug bottles and the atomizers is consistent with that of the trays, the medicine bottles are symmetrically arranged at the top end of the supporting rod by taking the supporting rod as a center, the atomizers are arranged on the side surface of the medicine bin, each medicine bottle is connected with the corresponding atomizer through the medicine conveying pipe, the support rod is provided with a controller of the atomizer, the medicine bin is internally provided with a medicine spraying opening, and the medicine spraying opening is communicated with the atomizer.
The tray is arranged on the supporting rod and used for supporting the medicine bin, the medicine bin is used for placing experimental animals, the medicine bottles are used for storing experimental medicines, a plurality of medicine bins can be used for simultaneously placing a plurality of or different types of experimental animals, each medicine bottle corresponds to one medicine bin, different medicine bottles can store different experimental medicines, airway experiments of various medicines can be simultaneously carried out, the medicine bins can be taken out of the tray, the positions of the medicine bins can be changed in the experiment process, so that the experimental animals can successively inhale different medicines, the combined medicine using experiment of different medicines is convenient, the medicines in the medicine bottles enter the atomizer through the medicine conveying pipe and are atomized, and then are sprayed into the medicine bin through the medicine spraying ports to be inhaled by the experimental animals, the controller is used for controlling the opening and closing of the atomizer, the animal is the initiative inhalation to the inhalation of medicine in the experimentation, is favorable to improving the experiment rate of accuracy, and can carry out the joint experiment of multiple medicine of multiple animal simultaneously, medicine and experimental animal not with the experimenter direct contact, guarantee safety, the animal also can freely move in the medicine storehouse, be convenient for observe the behavioural situation of change after the experimental animal inhales the medicine.
Further, the medicine storehouse includes transparent bulkhead, the bottom of the storehouse and top cap, top cap detachably lid is in the top of bulkhead, be equipped with the ventilation hole on the top cap, the bottom of the storehouse sets up bulkhead bottom, the bottom of the storehouse below is equipped with and takes scale buret, take scale buret's top is equipped with the sealing plug, the tray bottom is equipped with the confession take the bottom hole that scale buret passed, the ventilation hole can be guaranteed circulation of air in the medicine storehouse, take scale buret to be used for collecting the experiment back the waste liquid of condensation in the medicine storehouse, the accurate medicine suction volume of experimental animals of being convenient for is calculated, the sealing plug is used for sealing take scale buret, also conveniently pour the waste liquid when necessary and clear up.
Further, the tray with the cross sectional shape in medicine storehouse is regular hexagon, be equipped with in the medicine storehouse will six baffles of six equant divisions in medicine storehouse, every in the medicine storehouse spout medicine mouth also have six, set up respectively on six sides in medicine storehouse, can make the space maximize utilization in medicine storehouse is convenient for place more experimental animals simultaneously and is experimented.
Further, the baffle with the medicine storehouse is for dismantling the connection, can be according to the size of experimental animals size, through the installation or take out the baffle adjusts the size of medicine storehouse inner space, is convenient for place the experimental animals of different sizes of sizes simultaneously and experiments.
Furthermore, the medicine conveying pipe is provided with a detachable joint at the joint of the atomizer, and the medicine bin is replaced or changed at the position on the tray, so that the atomizer can be conveniently and differently changed through the detachable joint and the connection between the medicine conveying pipes.
Furthermore, the medicine conveying pipe is provided with an adjusting valve, and the adjusting valve is used for adjusting the medicine conveying speed of the medicine bottle to the atomizer, so that the amount of the atomized medicine in the medicine bin can be adjusted during the experiment.
Further, the bottom in medicine storehouse still is equipped with the metal mesh, the metal mesh can be when the bearing experiment animal be right animal hair or other impurity in the medicine storehouse keep apart, prevent that remaining medicine from flowing into carry impurity when taking in the scale graduated flask, influence experiment measuring result.
Furthermore, an inclination angle of 3 degrees is formed between the cross section of the bin bottom and the horizontal plane, and the graduated cylinder is arranged at the lowest end of the bin bottom, so that atomized and condensed medicines can conveniently flow into the graduated cylinder from the bin bottom, and residues are reduced.
Furthermore, the graduated cylinder is arranged obliquely, a certain inclination angle is formed between the graduated cylinder and the central axis of the medicine bin, and the medicine in the graduated cylinder can be poured out by conveniently unscrewing the sealing plug.
(III) the beneficial effects are as follows:
compared with the prior art, the invention has the following beneficial effects: (1) the atomizer is respectively connected with the medicine bottle and the medicine bin, and the medicine is atomized and sprayed into the medicine bin, so that the experimental animal can freely move in the medicine bin and naturally inhale the medicine, the medicine can uniformly act on the respiratory tract of the experimental animal, the behavior change condition of the animal in the experimental process can be conveniently observed, and the accuracy of the experimental result is ensured; (2) the supporting seat is provided with the plurality of trays, each tray is internally provided with the medicine bin which can be separated by the partition plate, and each medicine bin can be respectively dosed through the atomizer, so that the airway medicine experiment of various medicines and various animals can be simultaneously carried out, the combined medicine experiment can also be carried out, the experiment efficiency is greatly improved, and the workload of experimenters is effectively reduced; (3) the contact of experimental animals and medicines with people is isolated through the sealed medicine bin, and the experimenter can effectively avoid the condition that the experimenter inhales the medicines with toxicity or is accidentally injured by the animals in the experimental process through the control of the controller and the regulating valve.
Description of the drawings:
in order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings required to be used in the embodiments will be briefly described below.
FIG. 1 is a schematic diagram of an overall top view of an airway drug experiment system according to an embodiment of the present invention;
FIG. 2 is a top view of the internal structure of the cartridge of the airway drug experiment system according to the embodiment of the present invention;
FIG. 3 is a schematic cross-sectional view taken along line A-A of the cartridge of the airway drug testing system according to the embodiment of the present invention;
FIG. 4 is a schematic diagram of an overall cross-sectional structure of an airway drug experiment system B-B according to an embodiment of the present invention;
in the figure: 1. a supporting seat; 11. a base; 12. a support bar; 13. a tray; 14. a bottom hole; 2. a medicine bin; 21. a wall of the silo; 22. a bin bottom; 23. a top cover; 24. a vent hole; 25. a measuring tube with scales; 26. a sealing plug; 3. a drug delivery device; 31. a medicine bottle; 32. a drug delivery tube; 33. an atomizer; 34. a controller; 35. a medicine spraying port; 4. a partition plate; 5. a detachable joint; 6. adjusting a valve; 7. a metal mesh;
the specific implementation mode is as follows:
the technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
As shown in fig. 1, fig. 2, fig. 3 and fig. 4, the airway drug experiment system comprises a support base 1, a drug bin 2 and a drug delivery device 3, wherein the support base 1 comprises a support rod 12, a base 11 and trays 13 which are vertically arranged, the number of the trays 13 is 6, use the bracing piece 12 to set up around bracing piece 12 as central symmetry, base 11 sets up in 12 bottoms of bracing piece, all be equipped with medicine storehouse 2 in every tray 13, drug delivery device 3 includes medicine bottle 31, drug delivery pipe 32 and atomizer 33, the quantity of medicine bottle 31 and atomizer 33 also has 6, medicine bottle 31 uses bracing piece 12 to set up on the top of bracing piece 12 as central symmetry, atomizer 33 sets up the side at medicine storehouse 2, every medicine bottle 31 is connected with the atomizer 33 that corresponds respectively through drug delivery pipe 32, be equipped with the controller 34 of atomizer 33 on the bracing piece 12, be equipped with in the medicine storehouse 2 and spout medicine mouth 35, spout medicine mouth 35 and atomizer 33 intercommunication.
Preferably, the medicine bin 2 comprises a transparent bin wall 21, a bin bottom 22 and a top cover 23, the top cover 23 is detachably covered on the top of the bin wall 21, the top cover 23 is provided with a vent hole 24, the bin bottom 22 is arranged at the bottom of the bin wall 21, a graduated tube 25 is arranged below the bin bottom 22, a sealing plug 26 is arranged at the top end of the graduated tube 25, a bottom hole 14 for the graduated tube 25 to pass through is formed in the bottom of the tray 13, the vent hole 24 can ensure air circulation in the medicine bin 2, the graduated tube 25 is used for collecting waste liquid condensed in the medicine bin 2 after an experiment, so that the medicine suction volume of an experimental animal can be accurately calculated, the graduated tube 26 is used for sealing the graduated tube 25, and the waste liquid can be conveniently poured out for cleaning when necessary.
Preferably, tray 13 and medicine storehouse 2's cross sectional shape are regular hexagon, are equipped with six baffles 4 with six equant divisions of medicine storehouse 2 in the medicine storehouse 2, and the medicine mouth 35 that spouts in every medicine storehouse 2 also has six, sets up respectively on six sides of medicine storehouse 2, can make the space maximize utilization of medicine storehouse 2, is convenient for place more experimental animals simultaneously and experiments.
Preferably, baffle 4 and medicine storehouse 2 are for dismantling the connection, can be according to the size of experimental animals size, adjust the size of 2 inner spaces in medicine storehouse through the installation or take out baffle 4, are convenient for place the experimental animals of different sizes of sizes simultaneously and experiment.
Preferably, the connection between the drug delivery tube 32 and the atomizer 33 is provided with a detachable joint 5, so that when the drug cartridge 2 is replaced or the position on the tray 13 is changed, the connection between different atomizers 33 and drug delivery tubes 32 can be conveniently changed through the detachable joint 5.
Preferably, the medicine conveying pipe 32 is provided with an adjusting valve 6, and the adjusting valve 6 is used for adjusting the medicine conveying speed of the medicine bottle 31 to the atomizer 33, so as to adjust the amount of the atomized medicine in the medicine bin 2 during the experiment.
Preferably, the bottom in medicine storehouse 2 still is equipped with metal mesh 7, and metal mesh 7 can keep apart animal hair or other impurity in medicine storehouse 2 when the bearing experiment animal, carries impurity when preventing remaining medicine from flowing into in the graduated flask 25 of taking, influences experiment measuring result.
Preferably, the cross section of the bin bottom 22 has an inclination angle of 3 degrees with the horizontal plane, and the graduated cylinder 25 is arranged at the lowest end of the bin bottom 22, so that atomized and condensed medicine can conveniently flow into the graduated cylinder 25 from the bin bottom 22, and residue is reduced.
Preferably, the graduated cylinder 25 is arranged obliquely, and has a certain inclination angle with the central axis of the medicine bin 2, so that the medicine in the graduated cylinder 25 can be poured out conveniently by unscrewing the sealing plug 26.
The use method of the airway drug experiment system comprises the following steps:
different experimental animals with different sizes and different types are respectively put into different medicine cabins 2, the top cover 23 is covered, the size of the space in the medicine cabin 2 can be adjusted by installing or taking out the partition plate 4 according to the size of the body of the experimental animal, the experimental animals with different body sizes can be conveniently placed at the same time, the medicine cabin 2 is put into the tray 13, the atomizer 33 on the side surface of the medicine cabin 2 is connected with the medicine conveying pipe 32 through the detachable joint 5, different experimental medicines are put into different medicine bottles 31, each medicine bottle 31 corresponds to one medicine cabin 2, the atomizer 33 is started through the controller 34 to atomize the medicines, the medicines are sprayed into the medicine cabin 2 through the medicine spraying port to be inhaled by the experimental animal, the inflow speed of the medicines into the atomizer 33 can be adjusted through the adjusting valve 6, the amount of the atomized medicines in the medicine cabin 2 is adjusted when the experiment is convenient, the medicine cabin 2 can be discharged from the tray 13, the position of the medicine cabin 2 can be changed in, make the experimental animal successively inhale different medicines, be convenient for carry out the joint medication experiment of different medicines, the waste liquid of condensation flows into in the experiment back medicine storehouse 2 takes the scale graduated flask 25 in, be convenient for accurately calculate experimental animal's medicine suction volume, the animal is the initiative suction to the inhalation of medicine in the experimentation, be favorable to improving the experiment rate of accuracy, medicine and experimental animal do not with experimenter direct contact, guarantee safety, the animal also can be in medicine storehouse 2 free activity, be convenient for observe the behaviourological change condition after the experimental animal inhales the medicine, can clear up to taking the scale graduated flask 25 through unscrewing sealing plug 26 after the experiment finishes.
In conclusion, the airway drug experiment system provided by the invention is used for airway drug experiments, and solves the problems that experiment result deviation is easily caused in the existing airway drug experiments, one experimenter cannot simultaneously perform multiple groups of operations, the operation of many experimental animals wastes time and labor, the behavior change condition of the experimental animals cannot be observed, and potential safety hazards such as injury or poisoning exist in the experimenter.
The present invention has been described above by way of example, but the present invention is not limited to the above-described specific embodiments, and any modification or variation made based on the present invention is within the scope of the present invention as claimed.

Claims (9)

1. An airway drug experiment system is characterized in that: including supporting seat, medicine storehouse and the device of dosing, the supporting seat includes vertical bracing piece, base and the tray of establishhing, the tray has a plurality of, with the bracing piece sets up as central symmetry around the bracing piece, the base sets up bracing piece bottom, every all be equipped with in the tray the medicine storehouse, the device of dosing includes medicine bottle, drug delivery pipe and atomizer, the medicine bottle with the quantity of atomizer with the quantity of tray is unanimous, the medicine bottle with the bracing piece sets up as central symmetry the top of bracing piece, the atomizer sets up the side in medicine storehouse, every the medicine bottle passes through drug delivery pipe with correspond the atomizer is connected, be equipped with on the bracing piece the controller of atomizer, be equipped with in the medicine storehouse and spout the medicine mouth, spout the medicine mouth with the atomizer intercommunication.
2. An airway drug testing system according to claim 1 and characterised in that: the medicine storehouse includes transparent bulkhead, the bottom of the storehouse and top cap, top cap detachably lid the top of bulkhead, be equipped with the ventilation hole on the top cap, the bottom of the storehouse sets up bulkhead bottom, the bottom of the storehouse below is equipped with and takes scale buret, take scale buret's top is equipped with the sealing plug, the tray bottom is equipped with the confession take scale buret the bottom hole that passes.
3. An airway drug testing system according to claim 2 and characterised in that: the tray with the cross-sectional shape in medicine storehouse is regular hexagon, be equipped with in the medicine storehouse with six baffles of six equant divisions in the medicine storehouse, every in the medicine storehouse spout medicine mouth also have six, set up respectively on six sides in the medicine storehouse.
4. An airway drug testing system according to claim 3 wherein: the baffle with the medicine storehouse is for dismantling the connection.
5. An airway drug testing system according to claim 1 and characterised in that: the connection part of the medicine conveying pipe and the atomizer is provided with a detachable joint.
6. An airway drug testing system according to claim 1 and characterised in that: the medicine conveying pipe is provided with an adjusting valve.
7. An airway drug testing system according to claim 2 and characterised in that: the bottom of the medicine bin is also provided with a metal net.
8. An airway drug testing system according to claim 7 and characterized in that: an inclination angle of 3 degrees is formed between the cross section of the bin bottom and the horizontal plane, and the graduated measuring cylinder is arranged at the lowest end of the bin bottom.
9. An airway drug testing system according to claim 8 and characterised in that: the graduated cylinder is obliquely arranged and has a certain inclination angle with the central axis of the medicine bin.
CN202010056507.4A 2020-01-18 2020-01-18 Airway drug experiment system Pending CN111150521A (en)

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CN202010056507.4A CN111150521A (en) 2020-01-18 2020-01-18 Airway drug experiment system

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888044A (en) * 2020-07-24 2020-11-06 山西医科大学第一医院 Atomization drug delivery device for experimental animals
CN112704578A (en) * 2020-12-31 2021-04-27 西安医学院 Adjustable and controllable atomization inhalation device for small animals
CN114767320A (en) * 2022-04-29 2022-07-22 潍坊医学院 Atomized medicine detects box

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111184595A (en) * 2020-01-17 2020-05-22 华中科技大学同济医学院附属协和医院 Airway drug experiment system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111184595A (en) * 2020-01-17 2020-05-22 华中科技大学同济医学院附属协和医院 Airway drug experiment system

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888044A (en) * 2020-07-24 2020-11-06 山西医科大学第一医院 Atomization drug delivery device for experimental animals
CN112704578A (en) * 2020-12-31 2021-04-27 西安医学院 Adjustable and controllable atomization inhalation device for small animals
CN114767320A (en) * 2022-04-29 2022-07-22 潍坊医学院 Atomized medicine detects box

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