CN109342625A - With the integrated glycolated hemoglobin analysis pump head of vent valve - Google Patents
With the integrated glycolated hemoglobin analysis pump head of vent valve Download PDFInfo
- Publication number
- CN109342625A CN109342625A CN201811499459.5A CN201811499459A CN109342625A CN 109342625 A CN109342625 A CN 109342625A CN 201811499459 A CN201811499459 A CN 201811499459A CN 109342625 A CN109342625 A CN 109342625A
- Authority
- CN
- China
- Prior art keywords
- matrix
- valve
- fluid path
- valve body
- positioning sleeve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010054147 Hemoglobins Proteins 0.000 title claims abstract description 13
- 102000001554 Hemoglobins Human genes 0.000 title claims abstract description 13
- 239000011159 matrix material Substances 0.000 claims abstract description 26
- 239000012530 fluid Substances 0.000 claims abstract description 17
- 239000007788 liquid Substances 0.000 claims abstract description 9
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 230000008676 import Effects 0.000 claims 1
- 238000005070 sampling Methods 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 2
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/328—Control of physical parameters of the fluid carrier of pressure or speed valves, e.g. check valves of pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
It is simple that the present invention discloses a kind of structure, cost can be reduced, improve reliability with the integrated glycolated hemoglobin analysis pump head of vent valve, there is matrix, liquid-inlet is equipped in matrix, fluid path and liquid outlet, positioning sleeve is additionally provided on matrix, plunger rod passes through positioning sleeve and the hole by being arranged on matrix is communicated with fluid path, primary seal circle and secondary seal ring are provided between the positioning sleeve both ends and plunger rod, pressure spring is cased with outside the push rod to connect with plunger rod to be placed in sheath, the air vent communicated with fluid path is equipped in described matrix, valve body is connected to air vent taper sealing, valve rear end connects with the hand button being placed in outside pedestal, exhaust passage is equipped in valve body and hand button, there are valve seals between valve body and matrix.
Description
Technical field
The present invention relates to a kind of glycolated hemoglobin analysis pump head, especially a kind of structure is simple, can reduce cost, mention
High reliability with the integrated glycolated hemoglobin analysis pump head of vent valve.
Background technique
Glycosylated hemoglobin is glucose and hemoglobin cross-linking products in blood, when the concentration of glucose in blood is higher
When, it is also just relatively high that human body is formed by saccharification hemoglobin content.Therefore, glycosylated hemoglobin as diabetes screening,
Diagnosis, glycemic control, efficacy assessment effective Testing index, be widely used in clinic.Existing HbAle egg
The principle of white analyzer is identical as high performance liquid chromatograph, and structure is provided with three-way switch valve, and three-way switch valve is respectively with
One syringe pump, the second syringe pump, first liang of direction changeover valve and sampling valve (six tunnel switching valves) connect, with first liang of direction changeover valve phase
It is connected to cleaning liquid storage tank and second liang of direction changeover valve, sampling valve is connected by two direction changeover valve of third with sample introduction needle；There are two if
Mobile phase storage tank, two mobile phase storage tanks pass sequentially through degasser, proportion magnetic valve and a high-pressure pump, and (double plunger is in parallel past
Multiple pump) connect, the output of high-pressure pump passes sequentially through pressure transmitter again, pot strainer connects with sampling valve, and sampling valve leads to again
Chromatographic column is crossed to connect with detector.The pump head structure of the double plunger of existing glycolated hemoglobin analysis and connection reciprocating pump is that have base
Body is equipped with liquid-inlet, fluid path and liquid outlet on matrix, while being additionally provided with the plunger rod etc. communicated with fluid path in matrix
For aspirating mobile phase.Although being equipped with degasser, mobile phase can still generate more bubble in aspiration procedure, therefore existing
There is the pump head of glycolated hemoglobin analysis to pass through pipeline to connect with blow valve, device structure is relative complex, it is at high cost and
Be also easy to because connector is bad generate leakage the problems such as.
Summary of the invention
The present invention is to provide that a kind of structure is simple, can reduce to solve above-mentioned technical problem present in the prior art
Cost, improve reliability with the integrated glycolated hemoglobin analysis pump head of vent valve.
The technical solution of the invention is as follows: a kind of and integrated glycolated hemoglobin analysis pump head of vent valve has
Matrix is equipped with liquid-inlet, fluid path and liquid outlet in matrix, positioning sleeve is additionally provided on matrix, and plunger rod passes through positioning sleeve
And the hole by being arranged on matrix is communicated with fluid path, is provided with primary seal circle and pair between the positioning sleeve both ends and plunger rod
Sealing ring, the push rod to connect with plunger rod are cased with pressure spring outside and are placed in sheath, put in described matrix equipped with what is communicated with fluid path
Stomata is connected to valve body with air vent taper sealing, and valve rear end connects with the hand button being placed in outside pedestal, in valve body and hand button
Equipped with exhaust passage, there are valve seals between valve body and matrix.
The present invention is that the components such as vent valve and plunger rod are integrated, and can be saved material, reduces cost, and be can avoid
Cross leakage risk present in Multi-connecting head, good reliability, while can bubble effectively in exhaust flow phase, improve detection essence
Degree.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the embodiment of the present invention.
Fig. 2 is the A-A view of Fig. 1.
Fig. 3 is the B-B view of Fig. 1.
Specific embodiment
Of the invention is as shown in Figure 1, 2, 3 with the integrated glycolated hemoglobin analysis pump head of vent valve, there is matrix 1,
It is equipped with liquid-inlet 2, fluid path 3 and liquid outlet 4 in matrix 1, positioning sleeve 5 is additionally provided on matrix 1, plunger rod 6 passes through positioning
It covers 5 and the hole 7 by being arranged on matrix 1 is communicated with fluid path 3, it is close that master is provided between 5 both ends of positioning sleeve and plunger rod 6
Seal 8 and secondary seal ring 9, the push rod 10 to connect with plunger rod 6 are cased with pressure spring 11 outside and are placed in sheath 12, be equipped in matrix 1
The air vent 13 communicated with fluid path 3 is connected to valve body 14 with 13 taper sealing of air vent, 14 rear end of valve body and is placed in outside pedestal 1
Hand button 15 connect, in valve body 14 and hand button 15 be equipped with exhaust passage 16, have valve seals between valve body 14 and matrix 1
17。
The course of work:
In use, liquid-inlet 2 and liquid outlet 4 are connect with mobile phase fluid path respectively, mobile phase is aspirated repeatedly in plunger rod 6
Fluid path 3 is flowed through under effect.Can timing rotation hand button 15, the gas in fluid path 3 in mobile phase can be by valve body 14 and hand button 15
Exhaust passage 16 flow out.
Claims (1)
1. a kind of and integrated glycolated hemoglobin analysis pump head of vent valve, there is matrix (1), liquid is equipped in matrix (1)
Import (2), fluid path (3) and liquid outlet (4), it is characterised in that: be additionally provided on matrix (1) positioning sleeve (5), plunger rod (6)
Across positioning sleeve (5) and the hole (7) by being arranged on matrix (1) is communicated with fluid path (3), positioning sleeve (5) both ends and column
It is provided with primary seal circle (8) and secondary seal ring (9) between stopper rod (6), pressure spring is cased with outside the push rod (10) to connect with plunger rod (6)
(11) it is placed in sheath (12), the air vent (13) communicated with fluid path (3) is equipped in described matrix (1), with air vent (13)
Taper sealing is connected to valve body (14), and valve body (14) rear end connects with the hand button (15) of pedestal (1) outside is placed in, in valve body (14) and
Exhaust passage (16) are equipped in hand button (15), there are valve seals (17) between valve body (14) and matrix (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811499459.5A CN109342625A (en) | 2018-12-09 | 2018-12-09 | With the integrated glycolated hemoglobin analysis pump head of vent valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811499459.5A CN109342625A (en) | 2018-12-09 | 2018-12-09 | With the integrated glycolated hemoglobin analysis pump head of vent valve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109342625A true CN109342625A (en) | 2019-02-15 |
Family
ID=65303073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811499459.5A Pending CN109342625A (en) | 2018-12-09 | 2018-12-09 | With the integrated glycolated hemoglobin analysis pump head of vent valve |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109342625A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204789500U (en) * | 2015-06-08 | 2015-11-18 | 大连技嘉科技有限公司 | Pressure transmitter with bleed valve integration |
| CN207420843U (en) * | 2017-08-25 | 2018-05-29 | 大连技嘉科技有限公司 | With the integrated high-pressure pump of vent valve |
-
2018
- 2018-12-09 CN CN201811499459.5A patent/CN109342625A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204789500U (en) * | 2015-06-08 | 2015-11-18 | 大连技嘉科技有限公司 | Pressure transmitter with bleed valve integration |
| CN207420843U (en) * | 2017-08-25 | 2018-05-29 | 大连技嘉科技有限公司 | With the integrated high-pressure pump of vent valve |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200603 Address after: 215011 building 2-2-211, No.2, Peiyuan Road, high tech Zone, Suzhou City, Jiangsu Province Applicant after: Suzhou Borui Jiasheng Medical Technology Co.,Ltd. Address before: 116000 north side of No. 20, AI Xian street, hi tech Industrial Park, Dalian, Liaoning. Applicant before: DALIAN JIJIA TECHNOLOGY Co.,Ltd. |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190215 |