CN109316360A - A kind of fullerene intensively lifts Essence - Google Patents
A kind of fullerene intensively lifts Essence Download PDFInfo
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- CN109316360A CN109316360A CN201811179236.0A CN201811179236A CN109316360A CN 109316360 A CN109316360 A CN 109316360A CN 201811179236 A CN201811179236 A CN 201811179236A CN 109316360 A CN109316360 A CN 109316360A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The present invention relates to cosmetic technical fields, more particularly to a kind of fullerene intensively lifts Essence and preparation method thereof, the Essence includes the following raw material: water, fullerene, butanediol, ethoxy urea, glycerol, biological carbohydrate gum -1, trehalose, royal jelly, palmityl tetrapeptide -7,1,2- hexylene glycol, glycerol polymethacrylates, allantoin, glycerine polyacrylate, tranexamic acid, 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer, dipotassium glycyrrhizinate, xanthan gum, Sodium Hyaluronate, essence.Fullerene of the present invention intensively lifts Essence, has excellent effect at Firm lifting, anti-acne, antibacterial aspect；Use fullerene, trehalose and biological carbohydrate gum -1, three kind substance that there is synergistic function to Essence in raw material, and humidification is significant.
Description
Technical field
The present invention relates to cosmetic technical fields more particularly to a kind of fullerene intensively to lift Essence and its preparation side
Method.
Background technique
Cutis laxa performance index has rank in three, and primary index: pore highlights；Intermediate index: face contour fogs；
High grade index: relaxation is sagging；After showing themselves in that 25 years old respectively, skin blood circulation beginning is slack-off, and subcutaneous tissue fat deposit is also opened
Beginning becomes relaxation and is short of elasticity, reduces so as to cause the tension between pore, so that pore is shown.Even if weight does not increase
Add, the facial line from ear-lobe to chin also starts to become slack and undisciplined, and no longer smooth clearly demarcated, side, which is seen, to be especially apparent.Cheekbone
On skin it is no longer full compact, facial highest point is slowly vacillated down, starts nasolabial groove occur (also call enables line)；No
It is fat, but inevitably there is double chin.
Collagen is the main component for maintaining skin and the elasticity of muscle, and there are about 70% to be for the composition of corium in human skin
Collagen, major function are the elasticity for maintaining skin tension and keeping skin.With the increase at age, collagen is gradually
It reduces, loose and wrinkle occurs in skin.Collagen fabric becomes tiny, and the elasticity of elastin laminin also decreases, originally true
Collagen in cortex, which interacts the well-regulated mesh structure of composition with elastin laminin, to be gradually disintegrated, and it is raw to finally result in wrinkle
At skin starts aging relaxation.Collagen is referred to as " bone in bone, the skin in skin ", the collagen containing high-content in skin
Albumen is Firm lifting important leverage, can the Skin Cell of aging prop up again, to reach elimination microgroove, improve pine
It relaxes, lifts compact effect.
Currently, skin, which lifts compact effect, to be realized by using skin care item and medical and beauty treatment.Have wound, it is risky,
The operation Firm method of convalescence length has gradually been eliminated with the development of modern medicine beautifying technique.Based on this, the present invention is mentioned
For a kind of tightening effect, significantly a kind of fullerene intensively lifts Essence.
Summary of the invention
Technical problem to be solved by the present invention lies in it is intensive to provide a kind of effective fullerene of Firm anti-loosening
Lift Essence and preparation method thereof.
Present invention fullerene to be provided intensively lifts Essence and preparation method thereof, gives by following technical solution
It realizes:
A kind of fullerene intensively lifts Essence, by being prepared comprising following raw material: 80~140 parts of water, rich
Strangle 5~12 parts of alkene, 4~8 parts of butanediol, 1~5 part of ethoxy urea, 3~8 parts of glycerol, biological -1 2~5 part of carbohydrate gum, trehalose 2
~5 parts, 1~8 part of royal jelly, -7 2~10 parts of palmityl tetrapeptide, 4~10 parts of 1,2- hexylene glycol, glycerol polymethacrylates 3
~6 parts, 0.5~2.5 part of allantoin, 1.5~4.5 parts of glycerine polyacrylate, 0.1~1.5 part of tranexamic acid, in 1- methyl second
1~3 part of uride -2- acid imide, 0.1~1 part of dimethyl silicone polymer, 0.5~1.5 part of dipotassium glycyrrhizinate, xanthan gum 0.5~1
Part, 1~2 part of Sodium Hyaluronate, 0.1~0.5 part of essence.
As a preferred embodiment, the fullerene intensively lifts Essence, by preparing comprising following raw material
It obtains: 100~120 parts of water, 7~10 parts of fullerene, 5~7 parts of butanediol, 2~4 parts of ethoxy urea, 4~7 parts of glycerol, biology
3~4 parts of carbohydrate gum -1,3~4 parts of trehalose, 3~6 parts of royal jelly, -7 4~8 parts of palmityl tetrapeptide, 1,2- hexylene glycol 6~8
Part, 4~5 parts of glycerol polymethacrylates, 1~2 part of allantoin, 2~4 parts of glycerine polyacrylate, 0.6~1 part of tranexamic acid,
1.5~2.5 parts of 1- methyl hydantoin -2- acid imide, 0.4~0.7 part of dimethyl silicone polymer, dipotassium glycyrrhizinate 0.8~1.2
Part, 0.6~0.9 part of xanthan gum, 1.4~1.6 parts of Sodium Hyaluronate, 0.2~0.4 part of essence.
As a kind of optimal case, the fullerene intensively lifts Essence, by preparing comprising following raw material
It obtains: 110 parts of water, 8 parts of fullerene, 6 parts of butanediol, 3 parts of ethoxy urea, 6 parts of glycerol, biological -1 3.5 part of carbohydrate gum, trehalose
3.5 parts, 4.5 parts of royal jelly, -7 6 parts of palmityl tetrapeptide, 7 parts of 1,2- hexylene glycol, 4.5 parts of glycerol polymethacrylates, urine
1.5 parts of Bursin, 3 parts of glycerine polyacrylate, 0.8 part of tranexamic acid, 2 parts of 1- methyl hydantoin -2- acid imide, poly dimethyl silicon
0.5 part of oxygen alkane, 1 part of dipotassium glycyrrhizinate, 0.7 part of xanthan gum, 1.5 parts of Sodium Hyaluronate, 0.3 part of essence.
As a preferred embodiment, the essence is dried orange peel essence.
As a preferred embodiment, the preparation method of the trehalose, comprises the following steps:
(1) using the soluble starch of 25%~35 (W/V) as substrate, malt oligosaccharide based mycose synthetase is added, in pH
45~50h, mixed liquor filtering are reacted at 6.0~7.0,56~62 DEG C, filtering accuracy is 5 μm, obtains filtrate；
(2) mass fraction of filtrate evaporative crystallization to trehalose is 50~55%, then carries out crystallisation by cooling, works as crystallisation by cooling
Temperature when being down to 12~15 DEG C, obtain crystallisation by cooling liquid；
(3) crystallisation by cooling liquid is centrifuged, it is 1~1.3% that solid, which is dried to water content, obtains trehalose.
As a preferred embodiment, the preparation method of the biological carbohydrate gum -1, comprises the following steps:
(1) algae powder is taken, it is that 1g:60~70ml is added in distilled water by solid-liquid ratio that drying to constant weight, ultrasonic treatment 60~
80min, sonification power are 130~150W, and ultrasonic treatment temperature is 76~82 DEG C；
(2) 4000~5000r/min are centrifuged 3~5min, and extracting centrifugal liquid is concentrated, and concentrate is added to volume as concentration
In the dehydrated alcohol that 3.5~4 times of liquid, it is centrifuged after placing 12h with 4000~5000r/min, drying precipitate to constant weight obtains life
Object carbohydrate gum -1.
As a preferred embodiment, the preparation method of the Essence, comprises the following steps:
S1. water, biological carbohydrate gum -1, trehalose, royal jelly, glycerol polymethacrylates, glycerol are weighed according to parts by weight
Polyacrylate, 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer, dipotassium glycyrrhizinate, xanthan gum, essence, stirring
Uniformly, it is kept the temperature after heating, obtains mixture 1；
S2. mixture 1 cools down, and parts by weight butanediol, ethoxy urea, Sodium Hyaluronate is added, stirs evenly, is mixed
Object 2；
S3. it by parts by weight fullerene, allantoin, tranexamic acid, glycerol, stirs evenly, is kept the temperature after heating, obtain mixture 3；
S4. mixture 2,3 system of mixture in step S2., S3. are cooled down, then mixture 2, mixture 3 is mixed
It closes, stirs evenly, obtain mixture 4；
S5. mixture 4 cools down, and palmityl tetrapeptide -7,1,2- hexylene glycol is added, stirs evenly close to get the fullerene
Collection lifting Essence.
As a preferred embodiment, heating temperature described in S1. is 65~75 DEG C, and soaking time is 20~28min.
As a preferred embodiment, the cooling temperature range of mixture 1 described in S2. is 45~55 DEG C.
As a preferred embodiment, heating temperature described in S3. is 75~85 DEG C, and soaking time is 30~60min.
As a preferred embodiment, mixture 2 described in S4., 3 system of mixture cooling temperature range are 40~45
℃。
As a preferred embodiment, the cooling of mixture 4 described in S5. temperature range is 30~35 DEG C.
The utility model has the advantages that fullerene of the present invention intensively lifts Essence, in Firm lifting, anti-acne effect, antibacterial work
With etc. show excellent effect；Use fullerene, trehalose and biological carbohydrate gum -1, three kind substance to essence in raw material
Magnificent liquid has certain synergistic function, and humidification is obvious the effect of to Essence of the present invention.
Specific embodiment
It is explained further the present invention with reference to embodiments, but embodiment do not do any form to the present invention and limit.
A kind of fullerene of embodiment 1 intensively lifts Essence
Composition of raw materials: 110 parts of water, 8 parts of fullerene, 6 parts of butanediol, 3 parts of ethoxy urea, 6 parts of glycerol, biological carbohydrate gum -1
3.5 parts, 3.5 parts of trehalose, 4.5 parts of royal jelly, -7 6 parts of palmityl tetrapeptide, 7 parts of 1,2- hexylene glycol, glycerol polymethylacrylic acid
4.5 parts of ester, 1.5 parts of allantoin, 3 parts of glycerine polyacrylate, 0.8 part of tranexamic acid, 2 parts of 1- methyl hydantoin -2- acid imide,
0.5 part of dimethyl silicone polymer, 1 part of dipotassium glycyrrhizinate, 0.7 part of xanthan gum, 1.5 parts of Sodium Hyaluronate, 0.3 part of dried orange peel essence.
The trehalose the preparation method comprises the following steps:
(1) using the soluble starch of 30% (W/V) as substrate, malt oligosaccharide based mycose synthetase is added, in pH=
7.0,48h, mixed liquor filtering are reacted at 60 DEG C, filtering accuracy is 5 μm, obtains filtrate；
(2) mass fraction of filtrate evaporative crystallization to trehalose is 52%, then carries out crystallisation by cooling, when the temperature of crystallisation by cooling
When degree is down to 13 DEG C, crystallisation by cooling liquid is obtained；
(3) crystallisation by cooling liquid is centrifuged, it is 1.2% that solid, which is dried to water content, obtains trehalose.
The biological carbohydrate gum -1 the preparation method comprises the following steps:
(1) algae powder is taken, drying to constant weight, is that 1g:65ml is added in distilled water by solid-liquid ratio, is ultrasonically treated 70min, ultrasound
Processing power is 140W, and ultrasonic treatment temperature is 78 DEG C；
(2) 4500r/min is centrifuged 4min, and extracting centrifugal liquid is concentrated, and it is 3.8 times of concentrate that concentrate, which is added to volume,
In dehydrated alcohol, it is centrifuged after placing 12h with 4500r/min, drying precipitate to constant weight obtains biological carbohydrate gum -1.
The Essence the preparation method comprises the following steps:
S1. water, biological carbohydrate gum -1, trehalose, royal jelly, glycerol polymethacrylates, glycerol are weighed according to mass parts
Polyacrylate, 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer, dipotassium glycyrrhizinate, xanthan gum, dried orange peel essence,
It stirs evenly, after being heated to 70 DEG C, keeps the temperature 25min, obtain mixture 1；
S2. mixture 1 is cooled to 50 DEG C, and parts by weight butanediol, ethoxy urea, Sodium Hyaluronate is added, stirs evenly, obtains
To mixture 2；
S3. it by parts by weight fullerene, allantoin, tranexamic acid, glycerol, stirs evenly, after being heated to 80 DEG C, keeps the temperature 40min,
Obtain mixture 3；
S4. mixture 2,3 system of mixture in step S2., S3. are cooled to 42 DEG C, then by mixture 2, mixture 3 into
Row mixing, stirs evenly, obtains mixture 4；
S5. mixture 4 is cooled to 32 DEG C, and palmityl tetrapeptide -7,1,2- hexylene glycol is added, stirs evenly to get the richness
It strangles alkene and intensively lifts Essence.
A kind of fullerene of embodiment 2 intensively lifts Essence
Composition of raw materials: 80 parts of water, 5 parts of fullerene, 4 parts of butanediol, 1 part of ethoxy urea, 3 parts of glycerol, biological carbohydrate gum -1 2
Part, 2 parts of trehalose, 1 part of royal jelly, -7 2 parts of palmityl tetrapeptide, 4 parts of 1,2- hexylene glycol, 3 parts of glycerol polymethacrylates,
0.5 part of allantoin, 1.5 parts of glycerine polyacrylate, 0.1 part of tranexamic acid, 1 part of 1- methyl hydantoin -2- acid imide, poly- two
0.1 part of methylsiloxane, 0.5 part of dipotassium glycyrrhizinate, 0.5 part of xanthan gum, 1 part of Sodium Hyaluronate, 0.1 part of dried orange peel essence.
The preparation method of trehalose as described in example 2 and biological carbohydrate gum -1 is same as Example 1.
The preparation method of the Essence of embodiment 2 is same as Example 1.
A kind of fullerene of embodiment 3 intensively lifts Essence
Composition of raw materials: 140 parts of water, 12 parts of fullerene, 8 parts of butanediol, 5 parts of ethoxy urea, 8 parts of glycerol, biological carbohydrate gum -1
5 parts, 5 parts of trehalose, 8 parts of royal jelly, -7 10 parts of palmityl tetrapeptide, 10 parts of 1,2- hexylene glycol, glycerol polymethacrylates 6
Part, 4.5 parts of glycerine polyacrylate, 1.5 parts of tranexamic acid, 3 parts of 1- methyl hydantoin -2- acid imide, is gathered 2.5 parts of allantoin
1 part of dimethyl siloxane, 1.5 parts of dipotassium glycyrrhizinate, 1 part of xanthan gum, 2 parts of Sodium Hyaluronate, 0.5 part of dried orange peel essence.
The preparation method of trehalose described in embodiment 3 and biological carbohydrate gum -1 is same as Example 1.
The preparation method of the Essence of embodiment 3 is same as Example 1.
A kind of fullerene of embodiment 4 intensively lifts Essence
Composition of raw materials: the composition of raw materials of embodiment 4 is same as Example 1.
The preparation method of trehalose as described in example 4 and biological carbohydrate gum -1 is same as Example 1.
The Essence the preparation method comprises the following steps:
S1. water, biological carbohydrate gum -1, trehalose, royal jelly, glycerol polymethacrylates, glycerol are weighed according to mass parts
Polyacrylate, 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer, dipotassium glycyrrhizinate, xanthan gum, dried orange peel essence,
It stirs evenly, after being heated to 65 DEG C, keeps the temperature 20min, obtain mixture 1；
S2. mixture 1 is cooled to 45 DEG C, and parts by weight butanediol, ethoxy urea, Sodium Hyaluronate is added, stirs evenly, obtains
To mixture 2；
S3. it by parts by weight fullerene, allantoin, tranexamic acid, glycerol, stirs evenly, after being heated to 75 DEG C, keeps the temperature 30min,
Obtain mixture 3；
S4. mixture 2,3 system of mixture in step S2., S3. are cooled to 40 DEG C, then by mixture 2, mixture 3 into
Row mixing, stirs evenly, obtains mixture 4；
S5. mixture 4 is cooled to 30 DEG C, and palmityl tetrapeptide -7,1,2- hexylene glycol is added, stirs evenly to get the richness
It strangles alkene and intensively lifts Essence.
A kind of fullerene of embodiment 5 intensively lifts Essence
Composition of raw materials: the composition of raw materials of embodiment 5 is same as Example 1.
The preparation method of trehalose described in embodiment 5 and biological carbohydrate gum -1 is same as Example 1.
The Essence the preparation method comprises the following steps:
S1. water, biological carbohydrate gum -1, trehalose, royal jelly, glycerol polymethacrylates, glycerol are weighed according to mass parts
Polyacrylate, 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer, dipotassium glycyrrhizinate, xanthan gum, dried orange peel essence,
It stirs evenly, after being heated to 75 DEG C, keeps the temperature 28min, obtain mixture 1；
S2. mixture 1 is cooled to 55 DEG C, and parts by weight butanediol, ethoxy urea, Sodium Hyaluronate is added, stirs evenly, obtains
To mixture 2；
S3. it by parts by weight fullerene, allantoin, tranexamic acid, glycerol, stirs evenly, after being heated to 85 DEG C, keeps the temperature 60min,
Obtain mixture 3；
S4. mixture 2,3 system of mixture in step S2., S3. are cooled to 45 DEG C, then by mixture 2, mixture 3 into
Row mixing, stirs evenly, obtains mixture 4；
S5. mixture 4 is cooled to 35 DEG C, and palmityl tetrapeptide -7,1,2- hexylene glycol is added, stirs evenly to get the richness
It strangles alkene and intensively lifts Essence.
Embodiment 6
Composition of raw materials: 110 parts of water, 8 parts of fullerene, 6 parts of butanediol, 3 parts of ethoxy urea, 6 parts of glycerol, biological carbohydrate gum -1
3.5 parts (be purchased from Pu Rui biological medicine technology Co., Ltd), 3.5 parts of trehalose (being purchased from Wuhan Xin Weiye Chemical Co., Ltd.),
4.5 parts of royal jelly, -7 6 parts of palmityl tetrapeptide, 7 parts of 1,2- hexylene glycol, 4.5 parts of glycerol polymethacrylates, allantoin 1.5
Part, 3 parts of glycerine polyacrylate, 0.8 part of tranexamic acid, 2 parts of 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer 0.5
Part, 1 part of dipotassium glycyrrhizinate, 0.7 part of xanthan gum, 1.5 parts of Sodium Hyaluronate, 0.3 part of dried orange peel essence.The composition of raw materials of embodiment 6
Difference is with general commercially available biological carbohydrate gum -1, trehalose instead biological carbohydrate gum -1, trehalose of the present invention.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of embodiment 6 is same as Example 1.
Comparative example 1
Composition of raw materials: the composition of raw materials of comparative example 1 is not the difference from embodiment 1 is that add 3.5 parts by weight biology sugar
Glue -1, is added to 3.5 parts by weight trehaloses more, remaining component and content are identical.
The preparation method of trehalose described in comparative example 1 is same as Example 1.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of comparative example 1 is same as Example 1.
Comparative example 2
Composition of raw materials: the composition of raw materials of comparative example 2 is not the difference from embodiment 1 is that add 3.5 parts by weight seaweed
Sugar is added to 3.5 parts by weight biology carbohydrate gum -1 more, remaining component and content are identical.
The preparation method of biological carbohydrate gum -1 described in comparative example 2 is same as Example 1.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of comparative example 2 is same as Example 1.
Comparative example 3
Composition of raw materials: the composition of raw materials of comparative example 3 the difference from embodiment 1 is that do not add 8 parts by weight fullerenes,
It is added to 4 parts by weight trehaloses more, is added to 4 parts by weight biology carbohydrate gum -1, remaining component and content are identical more.
The preparation method of trehalose described in comparative example 3 and biological carbohydrate gum -1 is same as Example 1.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of comparative example 3 is same as Example 1.
Comparative example 4
Composition of raw materials: the composition of raw materials of comparative example 4 is not the difference from embodiment 1 is that add 3.5 parts by weight biology sugar
Glue -1 and 3.5 parts by weight trehaloses, are added to 7 parts by weight fullerenes more, remaining component and content are identical.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of comparative example 4 is same as Example 1.
Comparative example 5
Composition of raw materials: the composition of raw materials of comparative example 5 is not the difference from embodiment 1 is that add 3.5 parts by weight biology sugar
Glue -1 and 8 parts by weight fullerenes, are added to 11.5 parts by weight trehaloses more, remaining component and content are identical.
The preparation method of trehalose described in comparative example 5 is same as Example 1.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of comparative example 5 is same as Example 1.
Comparative example 6
Composition of raw materials: the composition of raw materials of comparative example 6 is not the difference from embodiment 1 is that add 3.5 parts by weight trehaloses
With 8 parts by weight fullerenes, it is added to 11.5 parts by weight biology carbohydrate gum -1, remaining component and content are identical more.
The preparation method of biological carbohydrate gum -1 described in comparative example 6 is same as Example 1.
The Essence the preparation method comprises the following steps: the preparation method of the Essence of comparative example 6 is same as Example 1.
Effect test:
The evaluation of 1 Firm of test case lifting effect
As dermal matrix index components, this functional materials can be used to judge skin texture and function weight collagen
The effect built, the collagen containing high-content is Firm lifting important leverage in skin
Method: using human skin fibroblasts and people's epidermal keratinocyte as system, addition film liquid cultivates cell, cultivates
After 60h, collagen content is measured with ELISA kit, calculates collagen rate of growth, as a result as shown in table 1 below.
Test case 2
The evaluation of bacteriostasis:
Propionibacterium acnes are the bacteriums that small pox is inflamed, and can be commented through the invention propionibacterium acnes inhibitory effect
Valence bacteriostasis and anti-acne effect.
It using inhibition zone method, is punched in test panel with sterilized punch or steel pipe, equivalent is injected into hole
The sample to be tested that mass concentration is 0.5% measures inhibition zone size after cultivating a period of time, is determined to press down according to inhibition zone size
The height of bacterium effect, as a result as shown in the following table 1.
Test case 3
The test and evaluation of anti-acne effect:
Tested crowd: face obviously has small pox
Tested number: 240 people are divided into 12 groups, and every group of tested number is 20 people.
Position on probation: face, the position of especially long acne
Use the time: 15 weeks
Evaluation method: software is analyzed by skin surface part analyzer VISIA CR (Canfield, the U.S.) and face-image
Photographic analysis is carried out before Image-Pro Plus (Media Cybernetics, Inc.) is on probation to subject and after use, is calculated
Inflammatory papules number or the per capita reduction amount of warts number per capita；It is excellent if reducing 80% or more；If reducing 60%-
80%, then it is good；It is preferable if reducing 40%-60%；If reduce 40% hereinafter, if to be poor, as a result such as the following table 1 institute
Show.
The evaluation of 1 Essence effect of table
It can be seen that by 1 data of table, the embodiment of the present invention 1 is best-of-breed technology scheme, and it is all best for surveying every effect；Implement
Example 1 is compared with embodiment 4~5, it is seen that if operating parameter is different from embodiment 1, the Essence effect being prepared is declined；
Embodiment 1 is compared with Example 6, it can be seen that if the present invention is with general commercially available biological carbohydrate gum -1, trehalose instead by the present invention
Biological carbohydrate gum -1, the trehalose that the preparation method obtains, the effect of will cause Essence of the present invention humidification not
Obviously, synergistic function is had no；Embodiment 1 is compared with comparative example 1~3, it is seen that be not added to biological carbohydrate gum -1, trehalose and
One of fullerene will cause the decline of the effect of Essence；Embodiment 1 is compared with comparative example 4~6, it is seen that only adds biology sugar
The effect of one of glue -1, trehalose and fullerene will cause Essence declines even more serious.
In conclusion fullerene of the present invention intensive lifting Essence living, to skin texture and reconstruction
Effect, Firm lifting, anti-acne effect, bacteriostasis etc. show excellent effect；Fullerene, life have been used in raw material
Object carbohydrate gum -1, trehalose, three kinds of substances have certain synergistic function, and enhancing is made the effect of to Essence of the present invention
With obvious.
Claims (10)
1. a kind of fullerene intensively lifts Essence, which is characterized in that the fullerene intensively lifts Essence, by comprising such as
Lower raw material is prepared: 80 ~ 140 parts of water, 5 ~ 12 parts of fullerene, 4 ~ 8 parts of butanediol, 1 ~ 5 part of ethoxy urea, glycerol 3 ~
8 parts, biological -1 2 ~ 5 part of carbohydrate gum, 2 ~ 5 parts of trehalose, 1 ~ 8 part of royal jelly, -7 2 ~ 10 parts of palmityl tetrapeptide, 1,2- hexylene glycol 4
~ 10 parts, 3 ~ 6 parts of glycerol polymethacrylates, 0.5 ~ 2.5 part of allantoin, 1.5 ~ 4.5 parts of glycerine polyacrylate, blood coagulation
0.1 ~ 1.5 part of acid, 1 ~ 3 part of 1- methyl hydantoin -2- acid imide, 0.1 ~ 1 part of dimethyl silicone polymer, dipotassium glycyrrhizinate 0.5 ~
1.5 parts, 0.5 ~ 1 part of xanthan gum, 1 ~ 2 part of Sodium Hyaluronate, 0.1 ~ 0.5 part of essence.
2. fullerene according to claim 1 intensively lifts Essence, which is characterized in that the fullerene intensively lifts
Essence, by being prepared comprising following raw material: 100 ~ 120 parts of water, 7 ~ 10 parts of fullerene, 5 ~ 7 parts of butanediol, hydroxyl second
2 ~ 4 parts of base urea, 4 ~ 7 parts of glycerol, biological -1 3 ~ 4 part of carbohydrate gum, 3 ~ 4 parts of trehalose, 3 ~ 6 parts of royal jelly, palmityl tetrapeptide -7 4 ~
8 parts, 6 ~ 8 parts of 1,2- hexylene glycol, 4 ~ 5 parts of glycerol polymethacrylates, 1 ~ 2 part of allantoin, glycerine polyacrylate 2 ~ 4
It is part, 0.6 ~ 1 part of tranexamic acid, 1.5 ~ 2.5 parts of 1- methyl hydantoin -2- acid imide, 0.4 ~ 0.7 part of dimethyl silicone polymer, sweet
0.8 ~ 1.2 part of oxalic acid dipotassium, 0.6 ~ 0.9 part of xanthan gum, 1.4 ~ 1.6 parts of Sodium Hyaluronate, 0.2 ~ 0.4 part of essence.
3. fullerene according to claim 1 intensively lifts Essence, which is characterized in that the fullerene intensively lifts
Essence, by being prepared comprising following raw material: 110 parts of water, 8 parts of fullerene, 6 parts of butanediol, 3 parts of ethoxy urea,
6 parts of glycerol, biological -1 3.5 part of carbohydrate gum, 3.5 parts of trehalose, 4.5 parts of royal jelly, -7 6 parts of palmityl tetrapeptide, 1,2- hexylene glycol 7
Part, 4.5 parts of glycerol polymethacrylates, 1.5 parts of allantoin, 3 parts of glycerine polyacrylate, 0.8 part of tranexamic acid, 1- methyl
2 parts of hydantoins -2- acid imide, 0.5 part of dimethyl silicone polymer, 1 part of dipotassium glycyrrhizinate, 0.7 part of xanthan gum, Sodium Hyaluronate
1.5 parts, 0.3 part of essence.
4. fullerene according to claim 1 intensively lifts Essence, which is characterized in that the essence is that dried orange peel is fragrant
Essence.
5. the preparation method that any fullerene of claim 1 ~ 4 intensively lifts Essence, which is characterized in that the essence
The preparation method of liquid comprises the following steps:
S1. water, biological carbohydrate gum -1, trehalose, royal jelly, glycerol polymethacrylates, glycerol poly- third are weighed according to parts by weight
Olefin(e) acid ester, 1- methyl hydantoin -2- acid imide, dimethyl silicone polymer, dipotassium glycyrrhizinate, xanthan gum, essence, stirring are equal
It is even, it is kept the temperature after heating, obtains mixture 1；
S2. mixture 1 cools down, and parts by weight butanediol, ethoxy urea, Sodium Hyaluronate is added, stirs evenly, obtains mixture 2；
S3. it by parts by weight fullerene, allantoin, tranexamic acid, glycerol, stirs evenly, is kept the temperature after heating, obtain mixture 3；
S4. mixture 2,3 system of mixture in step S2., S3. are cooled down, then mixture 2, mixture 3 is mixed, stirred
It mixes uniformly, obtains mixture 4；
S5. mixture 4 cools down, and palmityl tetrapeptide -7,1,2- hexylene glycol is added, stirs evenly and intensively mentions to get the fullerene
Draw Essence.
6. the preparation method that fullerene according to claim 5 intensively lifts Essence, which is characterized in that described in S1.
Heating temperature be 65 ~ 75 DEG C, soaking time be 20 ~ 28min.
7. the preparation method that fullerene according to claim 5 intensively lifts Essence, which is characterized in that described in S2.
Mixture 1 cooling temperature range be 45 ~ 55 DEG C.
8. the preparation method that fullerene according to claim 5 intensively lifts Essence, which is characterized in that described in S3.
Heating temperature be 75 ~ 85 DEG C, soaking time be 30 ~ 60min.
9. the preparation method that fullerene according to claim 5 intensively lifts Essence, which is characterized in that described in S4.
Mixture 2,3 system of mixture cooling temperature range be 40 ~ 45 DEG C.
10. the preparation method that fullerene according to claim 5 intensively lifts Essence, which is characterized in that described in S5.
Mixture 4 cool down temperature range be 30 ~ 35 DEG C.
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| CN110123733A (en) * | 2019-05-13 | 2019-08-16 | 广州丽彦妆生物科技有限公司 | A kind of fullerene Essence and preparation method thereof |
| CN112915045A (en) * | 2021-02-07 | 2021-06-08 | 广州市科能化妆品科研有限公司 | Composition for lifting and tightening skin and preparation method and application thereof |
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