CN109311945A - T细胞调节性多聚体多肽及其使用方法 - Google Patents

T细胞调节性多聚体多肽及其使用方法 Download PDF

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Publication number
CN109311945A
CN109311945A CN201780027232.8A CN201780027232A CN109311945A CN 109311945 A CN109311945 A CN 109311945A CN 201780027232 A CN201780027232 A CN 201780027232A CN 109311945 A CN109311945 A CN 109311945A
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polypeptide
amino acid
acid sequence
variant
cases
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R·D·塞戴尔第三
R·查帕罗
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Cue Biopharma Inc
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Cue Biopharma Inc
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
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    • C12N15/09—Recombinant DNA-technology
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001124—CD20
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    • A61K8/00—Cosmetics or similar toiletry preparations
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CN201780027232.8A 2016-03-02 2017-03-01 T细胞调节性多聚体多肽及其使用方法 Pending CN109311945A (zh)

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US201662302654P 2016-03-02 2016-03-02
US62/302,654 2016-03-02
PCT/US2017/020276 WO2017151818A2 (en) 2016-03-02 2017-03-01 T-cell modulatory multimeric polypeptides and methods of use thereof

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EP (1) EP3423108A4 (https=)
JP (1) JP2019516665A (https=)
KR (1) KR20180132663A (https=)
CN (1) CN109311945A (https=)
AU (1) AU2017226269B2 (https=)
CA (1) CA3014458A1 (https=)
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CN114126635A (zh) * 2019-05-29 2022-03-01 Cue生物制药股份有限公司 多聚体t细胞调节多肽及其使用方法
CN114423284A (zh) * 2019-09-20 2022-04-29 库尔生物制药有限公司 T细胞调节多肽及其使用方法

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CA2894511C (en) 2012-12-11 2021-12-07 Albert Einstein College Of Medicine Of Yeshiva University Methods for high throughput receptor:ligand identification
CN121159719A (zh) 2015-04-17 2025-12-19 高山免疫科学股份有限公司 具有可调的亲和力的免疫调节蛋白
US10273281B2 (en) 2015-11-02 2019-04-30 Five Prime Therapeutics, Inc. CD80 extracellular domain polypeptides and their use in cancer treatment
WO2017181152A2 (en) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
CN109689096A (zh) 2016-05-18 2019-04-26 阿尔伯特爱因斯坦医学院公司 变体pd-l1多肽、t细胞调节性多聚体多肽及其使用方法
WO2017201210A1 (en) 2016-05-18 2017-11-23 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
ES2973548T3 (es) 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
EP3565829A4 (en) 2017-01-09 2021-01-27 Cue Biopharma, Inc. T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHOD OF USING THEREOF
US20200010528A1 (en) 2017-03-15 2020-01-09 Cue Biopharma, Inc. Methods for modulating an immune response
SG11201907769XA (en) 2017-03-16 2019-09-27 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof
KR20190139216A (ko) 2017-04-28 2019-12-17 파이브 프라임 테라퓨틱스, 인크. Cd80 세포외 도메인 폴리펩티드를 이용한 치료 방법
JP2020534352A (ja) * 2017-09-07 2020-11-26 キュー バイオファーマ，インコーポレーテッド コンジュゲーション部位を有するｔ細胞調節多量体ポリペプチド及びその使用方法
EP3678677A4 (en) * 2017-09-07 2021-06-16 Cue Biopharma, Inc. Antigen-presenting polypeptides and methods of use thereof
CN111886241A (zh) 2018-01-09 2020-11-03 库尔生物制药有限公司 多聚体t细胞调节多肽及其使用方法
EP3897690A4 (en) * 2018-12-19 2022-09-28 Cue Biopharma, Inc. T LYMPHOCYTE MODULATOR MULTIMERIC POLYPEPTIDES HAVING CONJUGATION SITES AND METHODS OF USE THEREOF
US12589132B2 (en) 2019-02-22 2026-03-31 Five Prime Therapeutics, Inc. CD80 extracellular domain Fc fusion proteins for treating PD-L1 negative tumors
WO2020181272A1 (en) * 2019-03-06 2020-09-10 Cue Biopharma, Inc. Antigen-presenting polypeptides with chemical conjugation sites and methods of use thereof
DK4034170T3 (da) 2019-10-23 2026-03-30 Cue Biopharma Inc Tgf-beta-polypeptider
US20230126784A1 (en) * 2020-03-06 2023-04-27 Albert Einstein College Of Medicine A method to generate chimeric antigen receptor (car) t-cells (car-t cells) from pathogen-specific cytotoxic lymphocytes to enable the subsequent in vivo modulation of their functional activity
EP4118105A2 (en) * 2020-03-09 2023-01-18 Pfizer Inc. Cd80-fc fusion protein and uses thereof
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
US20230218731A1 (en) * 2020-05-26 2023-07-13 Cue Biopharma, Inc. Antigen Presenting Polypeptide Complexes and Methods of Use Thereof
WO2021242935A1 (en) * 2020-05-26 2021-12-02 Cue Biopharma, Inc. Antigen presenting polypeptide complexes and methods of use thereof
IL299834A (en) * 2020-07-14 2023-03-01 Cue Biopharma Inc with binding sites and methods for using them T - cellular modulatory polypeptides
WO2022056014A1 (en) 2020-09-09 2022-03-17 Cue Biopharma, Inc. Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof
CA3216273A1 (en) * 2021-04-21 2022-10-27 Ronald D. SEIDEL III Antigen presenting polypeptide complexes bearing tgf-beta and methods of use thereof
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Publication number Priority date Publication date Assignee Title
CN114126635A (zh) * 2019-05-29 2022-03-01 Cue生物制药股份有限公司 多聚体t细胞调节多肽及其使用方法
CN114423284A (zh) * 2019-09-20 2022-04-29 库尔生物制药有限公司 T细胞调节多肽及其使用方法

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JP2019516665A (ja) 2019-06-20
CA3014458A1 (en) 2017-09-08
AU2017226269A1 (en) 2018-09-06
WO2017151818A2 (en) 2017-09-08
US20190062400A1 (en) 2019-02-28
IL261401A (en) 2018-10-31
US20230227530A1 (en) 2023-07-20
EP3423108A2 (en) 2019-01-09
WO2017151818A3 (en) 2017-10-26
EP3423108A4 (en) 2019-10-02
KR20180132663A (ko) 2018-12-12

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Application publication date: 20190205