CN109310692B - 治疗眼部病状的方法 - Google Patents

治疗眼部病状的方法 Download PDF

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Publication number
CN109310692B
CN109310692B CN201780034734.3A CN201780034734A CN109310692B CN 109310692 B CN109310692 B CN 109310692B CN 201780034734 A CN201780034734 A CN 201780034734A CN 109310692 B CN109310692 B CN 109310692B
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formula
compound
iiib
iiia
nasal cavity
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CN201780034734.3A
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Chinese (zh)
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CN109310692A (zh
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D·M·阿克曼
J·劳丁
K·J·曼德尔
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Oyster Point Pharma Inc
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Oyster Point Pharma Inc
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Priority to CN202210040168.XA priority Critical patent/CN114432313A/zh
Priority to CN202210034408.5A priority patent/CN114533737B/zh
Publication of CN109310692A publication Critical patent/CN109310692A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201780034734.3A 2016-04-07 2017-04-06 治疗眼部病状的方法 Active CN109310692B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210040168.XA CN114432313A (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN202210034408.5A CN114533737B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319648P 2016-04-07 2016-04-07
US62/319,648 2016-04-07
PCT/US2017/026385 WO2017177024A1 (en) 2016-04-07 2017-04-06 Methods of treating ocular conditions

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202210034408.5A Division CN114533737B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN202210040168.XA Division CN114432313A (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Publications (2)

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CN109310692A CN109310692A (zh) 2019-02-05
CN109310692B true CN109310692B (zh) 2022-01-25

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CN201780034734.3A Active CN109310692B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN202210034408.5A Active CN114533737B (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法
CN202210040168.XA Pending CN114432313A (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

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CN202210040168.XA Pending CN114432313A (zh) 2016-04-07 2017-04-06 治疗眼部病状的方法

Country Status (19)

Country Link
US (3) US10709707B2 (https=)
EP (2) EP3439661B1 (https=)
JP (3) JP7090551B2 (https=)
KR (2) KR102485299B1 (https=)
CN (3) CN109310692B (https=)
AU (1) AU2017248276B2 (https=)
DK (1) DK3439661T3 (https=)
EA (1) EA201892265A1 (https=)
ES (1) ES2893126T3 (https=)
IL (3) IL299204A (https=)
MX (2) MX385698B (https=)
MY (1) MY199237A (https=)
NZ (1) NZ746468A (https=)
PH (1) PH12018502154A1 (https=)
PT (1) PT3439661T (https=)
SG (1) SG11201808650QA (https=)
TW (2) TWI790997B (https=)
WO (1) WO2017177024A1 (https=)
ZA (1) ZA201807438B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533737B (zh) * 2016-04-07 2024-05-31 奥伊斯特普安生物制药公司 治疗眼部病状的方法

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US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
SG10202011669PA (en) 2014-10-20 2020-12-30 Oyster Point Pharma Inc Methods of treating ocular conditions
TW202019417A (zh) 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 治療眼部症狀之正向異位調節劑與菸鹼乙醯膽鹼受體促效劑之組合
TW202019424A (zh) 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 治療眼部症狀之方法
ES3039903T3 (en) 2020-04-28 2025-10-27 Oyster Point Pharma Inc Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections
CN117355307A (zh) * 2021-05-07 2024-01-05 奥伊斯特普安生物制药公司 载体与烟碱激动剂的协同疗法
WO2026080563A1 (en) 2024-10-09 2026-04-16 Oyster Point Pharma, Inc. Simpinicline oral formations and use thereof

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CN114533737B (zh) * 2016-04-07 2024-05-31 奥伊斯特普安生物制药公司 治疗眼部病状的方法

Also Published As

Publication number Publication date
US10709707B2 (en) 2020-07-14
IL262102B (en) 2022-03-01
ES2893126T8 (es) 2022-05-23
TW201737917A (zh) 2017-11-01
CN114533737A (zh) 2022-05-27
TW202320785A (zh) 2023-06-01
TWI790997B (zh) 2023-02-01
BR112018070497A2 (pt) 2019-01-29
CA3020170A1 (en) 2017-10-12
US20200345734A1 (en) 2020-11-05
CN114432313A (zh) 2022-05-06
EP3439661B1 (en) 2021-08-04
PH12018502154A1 (en) 2019-07-08
AU2017248276A1 (en) 2018-11-22
WO2017177024A1 (en) 2017-10-12
JP2019513759A (ja) 2019-05-30
DK3439661T3 (da) 2021-10-18
EP3970724A1 (en) 2022-03-23
SG11201808650QA (en) 2018-10-30
PT3439661T (pt) 2021-09-30
ZA201807438B (en) 2024-09-25
ES2893126T3 (es) 2022-02-08
IL262102A (en) 2018-11-29
EA201892265A1 (ru) 2019-04-30
IL290069A (en) 2022-03-01
MY199237A (en) 2023-10-22
KR20190005859A (ko) 2019-01-16
CN114533737B (zh) 2024-05-31
US20250000861A1 (en) 2025-01-02
MX385698B (es) 2025-03-18
EP3439661A1 (en) 2019-02-13
KR20230010813A (ko) 2023-01-19
IL290069B2 (en) 2023-05-01
NZ785093A (en) 2024-07-05
JP7090551B2 (ja) 2022-06-24
JP2024103594A (ja) 2024-08-01
WO2017177024A8 (en) 2018-11-08
KR102512777B1 (ko) 2023-03-23
CN109310692A (zh) 2019-02-05
NZ746468A (en) 2023-06-30
KR102485299B1 (ko) 2023-01-06
IL290069B1 (en) 2023-01-01
IL299204A (en) 2023-02-01
AU2017248276B2 (en) 2023-07-13
TWI876258B (zh) 2025-03-11
MX2021010399A (es) 2022-01-18
US20190201397A1 (en) 2019-07-04
JP2022120125A (ja) 2022-08-17
MX2018012230A (es) 2019-03-28

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Inventor after: Trail Glass M Ackerman

Inventor after: J laudien

Inventor after: K J Mandel

Inventor before: D. M. Akman

Inventor before: J laudien

Inventor before: K J Mandel