CN109303904A - A kind of Chinese medicine composition and preparation method thereof for treating duck flower hepatopathy - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating duck flower hepatopathy Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract
The present invention relates to a kind of Chinese medicine compositions for treating duck flower hepatopathy, are prepared by radix bupleuri, radix scutellariae, the tuber of pinellia, Radix Codonopsis, the dried immature fruit of citron orange, Radix Paeoniae Alba, oriental wormwood, Poria cocos, rhizoma zingiberis, monkshood, peach kernel and safflower.The Chinese medicine composition can be powder, and preparation step is: (1) weighing each Chinese medicine by formula ratio；(2) Chinese medicine is crushed, crosses 40-100 mesh；(3) mixing 5-15min obtains traditional Chinese medicine powder；(4) traditional Chinese medicine powder is dispensed by every bag of 100-300g to get finished product.This prescription has the effect of nourishing blood and liver, heat-clearing and damp-drying drug, tonifying middle-Jiao and Qi, recover Yang and smooth venation, promoting blood circulation.Using traditional Chinese medicine composition for treating duck provided by the present invention flower hepatopathy, cure rate is up to 95.79%.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind of Chinese medicine composition for treating duck flower hepatopathy and its preparation side
Method.
Background technique
Duck flower hepatopathy is to cause a kind of acute, highly contagious disease of duckling by reovirus.Clinically with hair
It is sick anxious, propagate that fast, the death rate is high, liver has the downright bad point of white not of uniform size from surface to essence, and be spy in piebald shape
Venereal disease is levied to become.For this disease based on kind duck generation, Mule duck and sheldrake etc. also have infection, throughout the year can be popular, but with spring, summer
Wet season occurs more serious.The duckling for seeing 3 ages in days earliest, sees the middle duck of 50 ages in days, especially with 10 ages in days or so the latest
Duckling occur most frequently, disease incidence is 40%~90%, and the death rate is 40%~80%, causes very big economic damage to raiser
It loses.
Sick duck shows as that spirit is depressed, and malaise, foot is soft, appetite stimulator, diarrhea, row's white or green loose stool, grave illness
Duck is short of breath, body dehydration, thin rapidly, is finally died because dying of exhaustion.Its visible liver of dissect, pancreas swelling, fills spleen
Blood has white necrotic spot.
To the control of the disease, there has been no specific drugs at present, mainly aim at prevention.It can be prevented by maternal antibody 20
Duckling in age infects flower hepatopathy, to the duckling of no maternal antibody, injectable " flower hepatopathy " high immunity yolk antibody, preventive effect compared with
It is good but then not satisfactory to the protecting effect for symptom and dead sick duck group occurred, therefore be badly in need of developing and a kind of can effectively control
The newtype drug of duck flower hepatopathy processed.China's natural resources of Chinese medicinal materials is abundant, and theory of traditional Chinese medical science is of extensive knowledge and profound scholarship, the duck flower hepatopathy of Chinese medicine treatment at present
It reports also less, therefore makes full use of China's traditional advantage, developing a kind of Chinese materia medica preparation for duck flower hepatopathy is to treat this
One of effective way of disease.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies of the prior art and provide it is a kind of it is significant in efficacy, cure rate is high, secondary
Act on low Chinese medicine composition.
Another technical problem to be solved by the present invention is that: a kind of Chinese medicine preparation for treating duck flower hepatopathy is provided.
Another technical problem to be solved by the present invention is that: the preparation method of the powder of above-mentioned Chinese medicine composition is provided.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: a kind of Chinese traditional medicine composition for treating duck flower hepatopathy
Object, it is characterised in that: be prepared by the raw material of following mass fraction: 10-18 parts of radix bupleuri, 6-10 parts of radix scutellariae, 4-10 parts of the tuber of pinellia,
4-10 parts of Radix Codonopsis, 4-8 parts of the dried immature fruit of citron orange, 10-16 parts of Radix Paeoniae Alba, 8-12 parts of oriental wormwood, 5-8 parts of Poria cocos, 4-6 parts of rhizoma zingiberis, 4-6 parts of monkshood, peach
6-14 parts of benevolence, 6-14 parts of safflower.
Further, the mass fraction of the optimum feed stock of the Chinese medicine composition is as follows: 12 parts of radix bupleuri, 6 parts of radix scutellariae, the tuber of pinellia 6
Part, 8 parts of Radix Codonopsis, 6 parts of the dried immature fruit of citron orange, 12 parts of Radix Paeoniae Alba, 10 parts of oriental wormwood, 8 parts of Poria cocos, 6 parts of rhizoma zingiberis, 6 parts of monkshood, 10 parts of peach kernel, safflower 10
Part.
Further, which is the various conventional extract oral drug preparations for containing or not contain pharmaceutic adjuvant
Form.
Further, the preparation can be powder.
Further, the preparation method of the powder of the composition is: (1) weighing each Chinese medicine by formula ratio, (2) are by traditional Chinese medicine powder
It is broken, cross 40-100 mesh；(3) mixing 5-15min obtains traditional Chinese medicine powder；(4) by traditional Chinese medicine powder by every bag of 100-300g packing to get at
Product.
The advantages and positive effects of the present invention are:
(1) this prescription has nourishing blood and liver, heat-clearing and damp-drying drug, tonifying middle-Jiao and Qi, Hui Yangtong according to tcm theory, scientific compatibility
The effect of arteries and veins, promoting blood circulation, significant in efficacy through clinical examination treatment duck flower hepatopathy, cure rate is up to 95.79%.
(2) pharmacological action of each Chinese medicine material of the present invention is:
Radix bupleuri: soothing liver-qi stagnation, lifting disease；
Radix scutellariae: heat-clearing and damp-drying drug；
The tuber of pinellia: eliminating dampness and eliminating phlegm；
Radix Codonopsis: it invigorates the spleen and benefits qi；
The dried immature fruit of citron orange: relieving stagnant Qi disperse accumulation；
Radix Paeoniae Alba: suppressing liver-YANG, nourishing blood and liver；
Oriental wormwood: eliminating dampness and heat, normalizing gallbladder to cure jaundice；
Poria cocos: inducing diuresis for removing edema；
Rhizoma zingiberis: warming spleen and stomach for dispelling cold, recover Yang and smooth venation；
Monkshood: recuperating depleted yang, mends fire supporing yang；
Peach kernel: promoting blood circulation；
Safflower: blood circulation and channel invigorating, stasis-dispelling and pain-killing.
Among formula, radix bupleuri item reaches irritability, and soothing liver-qi stagnation rises the gas for lifting the clear sun of taste, controls the deficiency of qi in middle-jiao, collapse from qi deficiency institute
Cause deficiency of food and tireness, chronic diarrhea；The gas of Radix Codonopsis tonifying spleen lung controls the physically weak burnout of the deficiency of qi in middle-jiao, anorexia and loose stool；The dry stomach of the tuber of pinellia is wet, beneficial spleen
Stomach Qi removes stomach cold, into diet；Radix scutellariae taste bitter and cold, heat-clearing and damp-drying drug are longer than dampness-heat in upper jiao in clear especially；Dried immature fruit of citron orange relieving stagnant Qi removes ruffian, disperse accumulation
Promoting shares with radix scutellariae and controls damp-heat dysentery；Radix Paeoniae Alba convergence liver-yin is relieved pain with blood-nourishing, nourishing blood and liver, controls liver-blood deficiency, side of body rib pain
Bitterly；Oriental wormwood taste liver and gallbladder damp-heat sharp clearly, antipyretic liver protection；Poria cocos inducing diuresis for removing edema, invigorating the spleen excreting dampness and antidiarrheal；The high supplementing Yuanyang of monkshood；It is dry
During Jiang Wenyang is kept, recover Yang and smooth venation mutually must be used with monkshood, control deficiency-cold of the stomach, Yuanyang is wild；Peach kernel enters conscience blood system, lets out stasis,
Dissolving stasis power is strong；Safflower promoting blood circulation, and energy blood circulation and channel invigorating is to change stagnant ecchymose removing.
Above-mentioned 12 taste medicine compatible use has nourishing blood and liver, heat-clearing and damp-drying drug, tonifying middle-Jiao and Qi, recover Yang and smooth venation, promoting blood circulation
The effect of, treatment duck flower hepatopathy is significant in efficacy.
Specific embodiment
The present invention is further described below by specific embodiment, it is not limit that following embodiment, which is descriptive,
Qualitatively, this does not limit the scope of protection of the present invention.
Embodiment 1
A kind of traditional Chinese powder medicine for treating duck flower hepatopathy, the parts by weight of each raw material are as follows: 12 parts of radix bupleuri, 6 parts of radix scutellariae, the tuber of pinellia
6 parts, 8 parts of Radix Codonopsis, 6 parts of the dried immature fruit of citron orange, 12 parts of Radix Paeoniae Alba, 10 parts of oriental wormwood, 8 parts of Poria cocos, 6 parts of rhizoma zingiberis, 6 parts of monkshood, 10 parts of peach kernel, safflower 10
Part is prepared.Preparation method is: (1) weighing each Chinese medicine by formula ratio；(2) Chinese medicine is crushed, crosses 60 meshes；(3) it mixes
10min obtains traditional Chinese medicine powder；(4) traditional Chinese medicine powder is dispensed by every bag of 200g to get finished product.
Embodiment 2
A kind of traditional Chinese powder medicine for treating duck flower hepatopathy, the parts by weight of each raw material are as follows: 18 parts of radix bupleuri, 10 parts of radix scutellariae, half
10 parts of summer, 10 parts of Radix Codonopsis, 8 parts of the dried immature fruit of citron orange, 10 parts of Radix Paeoniae Alba, 8 parts of oriental wormwood, 6 parts of Poria cocos, 4 parts of rhizoma zingiberis, 4 parts of monkshood, 6 parts of peach kernel, safflower
6 parts are prepared.Preparation method is: (1) weighing each Chinese medicine by formula ratio；(2) Chinese medicine is crushed, crosses 60 meshes；(3) it mixes
10min obtains traditional Chinese medicine powder；(4) traditional Chinese medicine powder is dispensed by every bag of 200g to get finished product.
Embodiment 3
A kind of traditional Chinese powder medicine for treating duck flower hepatopathy, the parts by weight of each raw material are as follows: 10 parts of radix bupleuri, 7 parts of radix scutellariae, the tuber of pinellia
4 parts, 4 parts of Radix Codonopsis, 4 parts of the dried immature fruit of citron orange, 16 parts of Radix Paeoniae Alba, 12 parts of oriental wormwood, 5 parts of Poria cocos, 5 parts of rhizoma zingiberis, 5 parts of monkshood, 14 parts of peach kernel, safflower 14
Part is prepared.Preparation method is: (1) weighing each Chinese medicine by formula ratio；(2) Chinese medicine is crushed, crosses 60 meshes；(3) it mixes
10min obtains traditional Chinese medicine powder；(4) traditional Chinese medicine powder is dispensed by every bag of 200g to get finished product.
Clinical test
Experiment 1:
One raiser of Anhui Province Bengbu newly buys the raising of 1000 muscovy duckling seedlings, sudden onset when 20 age in days.Sick duck essence
Refreshing depressed, loss of appetite, feather is fluffy, matt, and malaise, foot is soft, draws white or green loose stool, and the breathing of grave illness duck is anxious
Promote, body dehydration is dead rapidly.Only the whole audience on the 2nd has fallen ill more than 100 only, and dead 12.Wherein 6 dead sick ducks are visible for dissect
Liver has blutpunkte, and liver, spleen have the small downright bad point of canescence, be in piebald shape, also have downright bad point, nephrorrhagia swelling, heart on pancreas
There is fibroid exudate, at bulk blutpunkte, the bursa of farbricius has fibroid exudation, bleeding.According to sick duck clinical symptoms and dissect knot
Fruit is diagnosed as duck flower hepatopathy.The muscovy duckling fallen ill is isolated immediately and is treated, the powder of Chinese traditional medicine obtained by the embodiment of the present invention 1
Agent spice, every 200g powder: 100Kg feed is twice a day used in conjunction 7 days.Remaining kind duck intramuscular injection that do not fall ill " flower hepatopathy "
Purification high immunity yolk antibody 1.5ml/ is only prevented.A the 2nd day dead kind duck number reduces to 4 after medication, does not occur again from the 3rd day
Death, the state of an illness are effectively controlled.It pays a return visit after half a month, full group has got well.
Experiment 1 the result shows that, the present invention obtained by traditional Chinese powder medicine treatment duck flower hepatopathy it is significant in efficacy, can obtain satisfied
Therapeutic effect.
Experiment 2:
It newly falls ill into a collection of kind newly-hatched duckling 1200 into 15 days after seedling at the beginning of Nanjing raiser 6 months.Illness kind
Duck spirit is depressed, appetite stimulator, and row's white or green loose stool, bipod is weak and feeble, part duck toe joint or gambrel swelling, happiness
It squats, neck is powerlessly sagging.The same day dead 6, second day The dead quantity increases to 15.Dissect death sick duck, it is seen that its liver
Dark red, enlargement, gather canescence necrosis point, and edge is uneven, matt, is in spider reticulation.According to sick duck clinical symptoms and flower
The feature of spot sample liver is diagnosed as duck flower hepatopathy.Sick duck is subjected to isolation treatment immediately, harmless treatment is only made to dead duck, it is right
Duck intramuscular injection " flower hepatopathy " high immunity yolk antibody 1.5ml/ is uninfected by only to be prevented.570 morbidity kind ducks are divided into three
Group, every group 190, different therapeutic schemes is respectively adopted: high immunity yolk antibody 2ml/ is only for first group of intramuscular injection " flower hepatopathy "；
Second group of " flower hepatopathy " high immunity yolk antibody (2ml/ is only)+benzylpenicillin potassium (80,000 IU/Kg)+virazole (15mg/Kg) intramuscular injection, one
It is primary, continuous injection 3 days；Traditional Chinese powder medicine spice obtained by the third group embodiment of the present invention 1, spice ratio are 200mg powder:
100Kg feed is twice a day used in conjunction 7 days.Each group treatment results are shown in Table 1:
Table 1: different pharmaceutical treatment duck flower hepatopathy curative effect compares
As it can be seen from table 1 " flower hepatopathy " high immunity yolk antibody group cure rate is only 51.58%, antibody combined penicillin
Potassium and virazole group cure rate are 72.11%, and traditional Chinese powder medicine group cure rate is 95.79%, hence it is evident that are higher than other two groups, have significant
Difference.
Experiment 2 the result shows that, traditional Chinese powder medicine of the present invention treatment duck flower hepatopathy good effect, cure rate is high, and without it is any not
Good reaction is suitble to clinical promotion and application.
The above, preferred embodiments only of the invention are illustrative without being restrictive, can be defined by
Range enumerates several embodiments, therefore the change and modification in the case where not departing from present general inventive concept, should belong to of the invention
Within protection scope.
Claims (5)
1. a kind of Chinese medicine composition for treating duck flower hepatopathy, which is characterized in that be prepared by the raw material of following mass fraction:
10-18 parts of radix bupleuri, 6-10 parts of radix scutellariae, 4-10 parts of the tuber of pinellia, 4-10 parts of Radix Codonopsis, 4-8 parts of the dried immature fruit of citron orange, 10-16 parts of Radix Paeoniae Alba, oriental wormwood 8-
12 parts, 5-8 parts of Poria cocos, 4-6 parts of rhizoma zingiberis, 4-6 parts of monkshood, 6-14 parts of peach kernel, 6-14 parts of safflower.
2. a kind of Chinese medicine composition for treating duck flower hepatopathy according to claim 1, it is characterised in that: the matter of optimum feed stock
It is as follows to measure number:
12 parts of radix bupleuri, 6 parts of radix scutellariae, 6 parts of the tuber of pinellia, 8 parts of Radix Codonopsis, 6 parts of the dried immature fruit of citron orange, 12 parts of Radix Paeoniae Alba, 10 parts of oriental wormwood, 8 parts of Poria cocos, rhizoma zingiberis 6
Part, 6 parts of monkshood, 10 parts of peach kernel, 10 parts of safflower.
3. the Chinese medicine composition for the treatment of duck flower hepatopathy according to claim 1 or 2, it is characterised in that: the Chinese medicine composition
It is the various conventional extract oral drug dosage forms for containing or not contain pharmaceutic adjuvant.
4. a kind of Chinese medicine composition for the treatment of duck flower hepatopathy according to claim 3, it is characterised in that: the preparation can be with
It is powder.
5. a kind of method for the traditional Chinese powder medicine for preparing treatment duck flower hepatopathy as claimed in claim 4, which is characterized in that preparation side
Method is: (1) weighing each Chinese medicine by formula ratio；(2) Chinese medicine is crushed, crosses 40-100 mesh；(3) mixing 5-15min obtains traditional Chinese medicine powder；
(4) traditional Chinese medicine powder is dispensed by every bag of 100-300g to get finished product.
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| CN101062171A (en) * | 2007-05-18 | 2007-10-31 | 湛江市第一兽药厂 | Method for producing bacterial virus element medicine for preventing bacterial virus mixed infection for critter, fowl and aquatic animals |
| CN101468067A (en) * | 2007-12-25 | 2009-07-01 | 郑州后羿制药有限公司 | Veterinary medicament for treating bacteriosis, virosis and mixed infection of bird and preparation method thereof |
| CN103272200A (en) * | 2013-05-31 | 2013-09-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine oral liquid for treating duck viral hepatitis and preparation method thereof |
| CN105434636A (en) * | 2015-12-21 | 2016-03-30 | 天农大（天津）生物科技有限公司 | Traditional Chinese medicine composition used for treating duckling hepatitis, and preparation method thereof |
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