CN109288934A - 一种痔疮中药制剂 - Google Patents
一种痔疮中药制剂 Download PDFInfo
- Publication number
- CN109288934A CN109288934A CN201811459990.XA CN201811459990A CN109288934A CN 109288934 A CN109288934 A CN 109288934A CN 201811459990 A CN201811459990 A CN 201811459990A CN 109288934 A CN109288934 A CN 109288934A
- Authority
- CN
- China
- Prior art keywords
- parts
- hemorrhoid
- materia medica
- chinese materia
- medica preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种痔疮中药制剂,其特征在于,其包括如下重量份的组分:苦参8.2‑10.5份;沙棘籽油3.2‑5.2份,雪莲3.2‑5.2份,藏红花3.2‑5.2份,蛇床子3.5‑5.5份,金银花3.0‑5.2份,板蓝根3.2‑5.2份,黄柏4.2‑5.2份,黄连2.0‑5.2,土荆皮3.0‑5.2份,花椒4.2‑5.2份。本发明一种痔疮中药制剂适用于:祛湿痒、各类痔疮、肛裂、肛瘘,祛核愈裂、抗炎阵痛,主要治疗消除痔疮核、肛裂、肛门瘙痒、止血止痒、抗菌消炎、抗肛周脓肿,具有良好的疗效,造福了痔疮病患者。
Description
技术领域
本发明涉及中药制剂领域,特别地,涉及一种痔疮中药制剂。
背景技术
痔疮一般是由便秘、盆腔肿瘤妊娠下迫、肝脏病潮湿等引发;痔疮分三种类形,内痔、外痔和混合痔,大的原发性为母痔,小的继发性为子痔,这三种痔疮给患者带来极在的痛苦。如不及时正确的治疗,影响正常工作、学习和生活。
目前,西医对该病常采用手术治疗、注射治疗或激光、冷冻等疗法,虽然治愈率较高,但存在患者痛苦大,安全系数较低且疗程长,易复发等缺点。而中医采用熏洗、外敷、肛门给药及一些内服药物等,虽然方法简便,但治疗效果不明显,治愈率较低。
发明内容
本发明的目的在于提供一种治疗效果明显,治愈率高的痔疮中药制剂。
本发明由如下技术方案实施:一种痔疮中药制剂,其特征在于,其包括如下重量份的组分:
君药:苦参8.2-10.5份;
臣药:沙棘籽油3.2-5.2份,雪莲3.2-5.2份,藏红花3.2-5.2份,蛇床子3.5-5.5份,金银花3.0-5.2份,板蓝根3.2-5.2份黄柏4.2-5.2份,黄连2.0-5.2,土荆皮3.0-5.2份,花椒4.2-5.2份。
进一步的,其还包括
佐药:天然茶树油3.0-5.2份,丁香3.2-5.2份,薄荷3.0-5.2份,紫花地丁3.0-5.2份,冰片4.2-5.2份,白芨4.5-5.5份,秦皮4.2-5.2份,马齿笕3.2-5.2份,大青叶3.0-5.2份,虎杖3.0-5.2份,鸭跖草3.0-5.2份,乌梅4.2-5.2份。
进一步的,其还包括
使药:稀土化合物4.2-5.2份,紫草4.2-5.2份。
进一步的,所述稀土化合物为硝酸铈或硫酸铈。
进一步的,所述稀土化合物为含有羟基、芳香基的稀土化合物。
进一步的,所述稀土化合物为钕化合物。
苦参是药用豆科槐属植物,苦参的干燥根,性寒味苦,始载于我国最早的《神农本草经》,据《本草纲目》记载:苦参、苦寒、无毒,具有清热解毒、祛风燥热、杀虫利尿等功效。随着分离提取技术的进步,发现苦参、苦豆子、广豆根存在同一类的苦参碱为代表的生物碱-苦参碱(matrine)、氧化苦参碱(oxymatrine),化学分子式分别为C15H24N2O和C15H24N2O2,分子量分别为266和288,是苦参型生物碱的主要活性成分,二者在一定条件下可以转化,有多方面的药理作用等功效,如抗菌、抗炎、抗寄生虫、抗心律失常、抗风湿、抗过敏、消肿利尿免疫及生物反应调节作用等。另研究苦参中含有黄酮类化合物,其主要成分为异戊二烯类黄酮,具有降血糖杀虫、抗菌、抗疟疾、抗肿瘤、抗心律失常等功能。
低浓度稀土化合物具有抑菌、杀菌和抗炎作用,如0.25%-0.5%的硝酸铈、硫酸铈溶液对绿浓杆菌、金色葡萄球菌、肺炎杆菌、奇异变形杆菌、粪链球菌、大肠杆菌、产碱假单胞菌、表皮葡萄球菌等有强烈的杀灭作用,作为烧伤药物,它的霜剂在全国8个医院临床使用发现,对烧伤早期和晚期的创面有较强的杀菌作用,而且不需要使用其他杀菌药物配合治疗。其次它有促进创面愈合的作用,同等条件愈合期比磺胺嘧啶银、洗必泰、新洁尔灭等可缩短3-5天,总共观察424例,总有效率达99%。
60年代以来还发现含有羟基、芳香基的稀土化合物具有消炎杀菌作用,其中钕化合物的作用比其他稀土元素大。国外利用稀土消炎杀菌性能在临床大量使用,如将钛铁制剂钐制成软膏,对治疗湿疹、过敏性皮炎、牙龈炎、鼻炎、静脉炎等取得很好的疗效。
本发明的优点:
本发明一种痔疮中药制剂适用于:祛湿痒、各类痔疮、肛裂、肛瘘,祛核愈裂、抗炎阵痛,主要治疗消除痔疮核、肛裂、肛门瘙痒、止血止痒、抗菌消炎、抗肛周脓肿,具有良好的疗效,造福了痔疮病患者。
具体实施方式:
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
一种痔疮中药制剂,包括如下重量份的组分:
取苦参82g,加浓度为60%乙醇溶液1000ml,煎煮2.5小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
取雪莲32g,藏红花32g,蛇床子35g,金银花30g,板蓝根32g,黄柏42g,黄连20g,土荆皮30g,花椒42g;加浓度为60%乙醇溶液1000ml,煎煮3小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,加入薄荷30g,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
将上述两次醇提得到的滤液合并,加入沙棘籽油32g,浓缩,得到痔疮洗剂。
实施例2:
一种痔疮中药制剂,包括如下重量份的组分:
取苦参82g,加浓度为60%乙醇溶液1000ml,煎煮2.5小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
取丁香32g,雪莲32g,紫花地丁30g,硝酸铈42g,藏红花32g,冰片42g,白芨45g,蛇床子35g,紫草42g,金银花30g,秦皮42g,板蓝根32g,黄柏42g,马齿笕32g,黄连20g,土荆皮30g,大青叶30g,虎杖30g,鸭跖草30g,花椒42g,乌梅42g;加浓度为60%乙醇溶液1000ml,煎煮3小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,加入薄荷30g,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
将上述两次醇提得到的滤液合并,加入沙棘籽油32g和天然茶树油30g,浓缩,得到痔疮洗剂。
实施例3:
取苦参82g,加浓度为60%乙醇溶液1000ml,煎煮2.5小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
取丁香40g,雪莲40g,紫花地丁40g,硝酸铈40g,藏红花40g,冰片45g,白芨50g,蛇床子45g,紫草45g,金银花40g,秦皮45g,板蓝根40g,黄柏45g,马齿笕40g,黄连35g,土荆皮40,大青叶40g,虎杖40g,鸭跖草40g,花椒45g,乌梅45g;加浓度为60%乙醇溶液1000ml,煎煮3小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,加入薄荷40g,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
将上述两次醇提得到的滤液合并,加入沙棘籽油40g和天然茶树油40g,浓缩,得到痔疮洗剂。
实施例4:
取苦参82g,加浓度为60%乙醇溶液1000ml,煎煮2.5小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
取丁香52g,雪莲52g,紫花地丁52g,钕化合物52g,藏红花52g,冰片52g,白芨55g,蛇床子55g,紫草52g,金银花52g,秦皮52g,板蓝根52g,黄柏52g,马齿笕52g,黄连52g,土荆皮52,大青叶52g,虎杖52g,鸭跖草52g,花椒52g,乌梅52g;加浓度为60%乙醇溶液1000ml,煎煮3小时,过滤,滤液备用,取残渣加入浓度为55%乙醇溶液800ml,加入薄荷52g,煎煮1.5小时,过滤,滤液备用,合并两次滤液,静置过滤,滤液备用;
将上述两次醇提得到的滤液合并,加入沙棘籽油52g和天然茶树油52g,浓缩,得到痔疮洗剂。
实施例5、确定实施例1、2、3、4所述痔疮洗剂的止血疗效。
取60只小鼠,按体重随机分成5组,分别为正常对照组和实验组(实施例1组、实施例2组、实施例3组、实施例4组),采用小鼠断尾法测定各组止血时间:即实验组切断小鼠尾巴2cm后立即用实施例1、2、3、4制得的痔疮洗剂清洗,正常对照组切断小鼠尾巴后不做处理,观察各组小鼠的平均止血时间,实验结果列于表1。
表1小鼠断尾法测定各组止血时间表(min)
实施例1组 | 实施例2组 | 实施例3组 | 实施例4组 | 正常对照组 | |
止血时间/s | 3.2±0.5 | 3.1±0.6 | 3.1±0.5 | 3.0±0.4 | 3.5±0.6 |
进一步的,取60只小鼠,按体重随机分成5组,分别为正常对照组(蒸馏水)和实验组(实施例1组、实施例2组、实施例3组、实施例4组),采用99.0%醋酸致小鼠肛周溃疡,评定溃疡程度,实验组对应用实施例1、2、3、4制得的痔疮洗剂清洗,正常对照组不做处理,方法为:取一张滤纸,用内径6mm的打孔器制成大小相等的滤纸片,展开滤纸,放入99.0%的醋酸溶液中,充分浸泡,分别降浸泡后的滤纸片放到肛周,使滤纸片紧密接触肛周皮肤及粘膜,每次粘贴1min,隔0.5min更换一次滤纸片。从致溃疡的第二天开始,用纱布巾浸润药物后外敷各组药物于溃疡处,每次用药5min,连续给药11天,并观察致溃疡后3,5,7,9,11d溃疡愈合情况,评定溃疡程度(评定标准,有溃疡渗液1分,有少量溃疡渗液2份,有焦痂、基本愈合3分,完全愈合4分),实验结果列于表2。
表2小鼠肛周溃疡评分
3d | 5d | 7d | 9d | 11d | |
空白对照 | 1.45±0.34 | 1.50±0.38 | 1.59±0.44 | 1.88±0.43 | 2.12±0.61 |
实施例1 | 2.34±0.48 | 2.42±0.52 | 2.48±0.32 | 2.86±0.57 | 3.00±0.51 |
实施例2 | 2.39±0.43 | 2.43±0.42 | 2.56±0.39 | 2.90±0.56 | 3.06±0.55 |
实施例3 | 2.40±0.50 | 2.43±0.47 | 2.55±0.48 | 2.87±0.52 | 3.02±0.53 |
实施例4 | 2.50±0.44 | 2.52±0.47 | 2.60±0.56 | 2.96±0.41 | 3.11±0.53 |
结论:实施例1、2、3、4制得的痔疮洗剂对小鼠肛周溃疡有着较好的治疗作用;而且实施例1、2、3、4制得的痔疮洗剂对小鼠断尾的止血作用依次加强,由此可见本发明君药和臣药的组合物,已经具有很好的治疗作用;。
实施例6、确定实施例1、2、3、4所述痔疮洗剂的抗菌消炎、抗肛周脓肿的疗效。
取60只小鼠,按体重随机分成5组,分别为正常对照组(蒸馏水)和实验组(实施例1组、实施例2组、实施例3组、实施例4组),采用在小鼠右耳施用二甲苯,左耳不作处理作为对照计算,而后实验组立即用实施例1、2、3、4制得的痔疮洗剂清洗右耳,十五分钟后处死,观察各组小鼠的右耳肿胀情况,观察得到,正常对照组的小鼠右耳出现明显的肿胀,而实验组的小鼠虽然出现肿胀,但是肿胀程度均不明显。结论:实施例1、2、3、4所述痔疮洗剂具有抗菌消炎、抗肿胀的作用。
表3,抗肿胀度疗效试验
表4本发明原料来源
原料 | 购买单位 | 购买日期 |
茶树油 | 呼和浩特市海日瀚生物技术有限公司 | 20160311 |
沙棘籽油 | 呼和浩特市海日瀚生物技术有限公司 | 20160311 |
硝酸铈 | 包头市华星稀土科技有限公司 | 20160226 |
其他中药药味 | 呼和浩特市孙冀生物医药有限责任公司 | 20160113 |
以上所述仅为本发明的较佳实施例而已,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (6)
1.一种痔疮中药制剂,其特征在于,其包括如下重量份的组分:
苦参8.2-10.5份;
沙棘籽油3.2-5.2份,雪莲3.2-5.2份,藏红花3.2-5.2份,蛇床子3.5-5.5份,金银花3.0-5.2份,板蓝根3.2-5.2份,黄柏4.2-5.2份,黄连2.0-5.2,土荆皮3.0-5.2份,花椒4.2-5.2份。
2.根据权利要求1所述的一种痔疮中药制剂,其特征在于,其还包括
天然茶树油3.0-5.2份,丁香3.2-5.2份,薄荷3.0-5.2份,紫花地丁3.0-5.2份,冰片4.2-5.2份,白芨4.5-5.5份,秦皮4.2-5.2份,马齿笕3.2-5.2份,大青叶3.0-5.2份,虎杖3.0-5.2份,鸭跖草3.0-5.2份,乌梅4.2-5.2份。
3.根据权利要求1所述的一种痔疮中药制剂,其特征在于,其还包括
稀土化合物4.2-5.2份,紫草4.2-5.2份。
4.根据权利要求3所述的一种痔疮中药制剂,其特征在于,所述稀土化合物为硝酸铈或硫酸铈。
5.根据权利要求3所述的一种痔疮中药制剂,其特征在于,所述稀土化合物为含有羟基、芳香基的稀土化合物。
6.根据权利要求3或5所述的一种痔疮中药制剂,其特征在于,所述稀土化合物为钕化合物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811459990.XA CN109288934A (zh) | 2018-11-30 | 2018-11-30 | 一种痔疮中药制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811459990.XA CN109288934A (zh) | 2018-11-30 | 2018-11-30 | 一种痔疮中药制剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109288934A true CN109288934A (zh) | 2019-02-01 |
Family
ID=65141981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811459990.XA Pending CN109288934A (zh) | 2018-11-30 | 2018-11-30 | 一种痔疮中药制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109288934A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118477014A (zh) * | 2024-05-13 | 2024-08-13 | 浙江爱尚日用品有限公司 | 去渍增白、抗炎镇痛、抗幽门螺旋杆菌的牙膏 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107714845A (zh) * | 2017-11-30 | 2018-02-23 | 康凤岐 | 一种药物组合物及其制剂和用途 |
-
2018
- 2018-11-30 CN CN201811459990.XA patent/CN109288934A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107714845A (zh) * | 2017-11-30 | 2018-02-23 | 康凤岐 | 一种药物组合物及其制剂和用途 |
CN108272915A (zh) * | 2017-11-30 | 2018-07-13 | 康凤岐 | 一种药物组合物及其制剂和用途 |
Non-Patent Citations (2)
Title |
---|
苗健等主编: "《微量元素与相关疾病》", 31 December 1997, 河南医科大学出版社 * |
郭加朋主编: "《工业维生素 稀土》", 30 June 2016, 山东科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118477014A (zh) * | 2024-05-13 | 2024-08-13 | 浙江爱尚日用品有限公司 | 去渍增白、抗炎镇痛、抗幽门螺旋杆菌的牙膏 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101445010B1 (ko) | 소염, 부기제거, 진통에 사용되는 중국 생약 조성물, 그 제조 방법 및 용도 | |
EA018425B1 (ru) | Фармацевтический, дезинфицирующий или консервирующий экстракт пажитника сенного (trigonella foenum-graecum), способ его получения и применение экстракта | |
US20120328721A1 (en) | Aloe vera sprout concentrate or extract having superior skin cell growth promotion, antioxidant, and anti-allergy effects | |
CN108685769A (zh) | 一种复方中药乌发防脱洗发水及其制备方法 | |
CN106860482A (zh) | 蜂胶乙醇提取物的应用 | |
JP4495406B2 (ja) | センダングサ属植物抽出物含有組成物 | |
CN111437225A (zh) | 一种止血生肌抗菌组合物及其应用 | |
CN110339249B (zh) | 一种用于痔疮肛裂的中药组合物及其制备方法和应用 | |
CN112741795A (zh) | 一种含有天然植物提取物成分的护肤沐浴露及制备方法 | |
CN110327232B (zh) | 一种救必应漱口水 | |
CN109288934A (zh) | 一种痔疮中药制剂 | |
CN107913301A (zh) | 一种用于女性私处养护的中药组合物及其含该组合物提取物的精华液 | |
JP6590233B1 (ja) | 皮膚疾患治療剤及びその製造方法 | |
CN110755340A (zh) | 一种含有天然植物提取物成分的护肤沐浴液及其制备方法 | |
CN114306526B (zh) | 一种复方苦丁茶中药提取物及其在制备沐浴露或洗手液中的应用 | |
CN113616774B (zh) | 一种含植物干细胞的抑菌组合物、养护抑菌液及其制备方法 | |
JP2007084448A (ja) | ヒアルロン酸産生促進剤および皮膚外用剤 | |
JP2007045733A (ja) | ヒアルロニダーゼ阻害剤 | |
CN112755143B (zh) | 一种治疗湿疹的中药组合物及其应用 | |
EP1539201B1 (en) | Antipyrotic and method of manufacturing the same | |
JP2004244370A (ja) | ニキビ用の皮膚外用剤 | |
CN107982300B (zh) | 一种喷雾剂及其制备方法和应用 | |
CN107569580B (zh) | 一种治疗痔疮的外用中药组合物及其制备方法 | |
JP5325727B2 (ja) | センダングサ属植物抽出物含有組成物 | |
CN113813308A (zh) | 一种治疗烧烫伤的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190201 |
|
RJ01 | Rejection of invention patent application after publication |