CN109258713A - A kind of Chinese medicine corrosion-proof and sterilization agent and preparation method thereof - Google Patents
A kind of Chinese medicine corrosion-proof and sterilization agent and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine corrosion-proof and sterilization agent and preparation method thereof, are related to the field of Chinese medicines.According to parts by weight, raw material includes the climbing groundsel of 20-30 parts by weight, the honeysuckle of 20-30 parts by weight, the chrysanthemum of 20-30 parts by weight, the peppermint of 20-30 parts by weight, the ethyl alcohol of 15-25 parts by weight and 4-6 parts by weight to chloroxylenol for the Chinese medicine corrosion-proof and sterilization agent.The Chinese medicine corrosion-proof and sterilization agent prescription is reasonable, can effectively be rapidly achieved disinfection and sterilization corrosion-resistant effect, can be used for include skin, mucous membrane, clothing, household, farm and epidemic situation protection etc. disinfection.Preparation method includes the following steps: decocting climbing groundsel, honeysuckle, chrysanthemum and peppermint, obtains decoction liquor, is cooled to 40 DEG C hereinafter, adjusting pH value is 9-10.5, standing collects supernatant, and dehydration obtains Chinese medical extract.Mixing is to chloroxylenol, ethyl alcohol and Chinese medical extract.The preparation method is simple, and time-consuming short, process is easily-controllable.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine corrosion-proof and sterilization agent and preparation method thereof.
Background technique
With the development of economic society and the progress of modern science and technology, huge change is had occurred in environment for human survival, living standard
Change.Great variety, understanding of the mankind to health also just occur for adaptable human diseases spectrum, medical model and medical model therewith
It is continuously improved, the pursuit of health is increasingly enhanced, the international market of traditional medicine is continuously increased.The doctor growing in face of various countries
Health care expense is treated, modern medicine cannot sufficiently meet worldwide disease preventing and treating, sanatory great demand, international
Society has appreciated that the knot of the health care theory of traditional medicine, especially traditional Chinese medicine, the validity of medical practice and modern medicine
Conjunction will likely provide medical and health care new model for the mankind.
Summary of the invention
One of the objects of the present invention is to provide a kind of Chinese medicine corrosion-proof and sterilization agent, and the Chinese medicine corrosion-proof and sterilization agent prescription is reasonable,
It can be effectively rapidly achieved disinfection and sterilization corrosion-resistant effect, can be used for including skin, mucous membrane, clothing, household, farm and epidemic situation
The disinfection of protection etc..
Another object of the present invention is to provide a kind of preparation methods of above-mentioned Chinese medicine corrosion-proof and sterilization agent.
The present invention solves its technical problem and adopts the following technical solutions to realize.
The invention proposes a kind of Chinese medicine corrosion-proof and sterilization agent, according to parts by weight, the raw material packet of the Chinese medicine corrosion-proof and sterilization agent
Include the climbing groundsel of 20-30 parts by weight, the honeysuckle of 20-30 parts by weight, the chrysanthemum of 20-30 parts by weight, 20-30 parts by weight it is thin
Lotus, the ethyl alcohol of 15-25 parts by weight and 4-6 parts by weight to chloroxylenol.
The invention also provides a kind of preparation methods of above-mentioned Chinese medicine corrosion-proof and sterilization agent, comprising the following steps:
Climbing groundsel, honeysuckle, chrysanthemum and peppermint are decocted, decoction liquor is obtained, is cooled to 40 DEG C hereinafter, adjusting pH value is 9-
10.5, it stands, collects supernatant, dehydration obtains Chinese medical extract.
Mixing is to chloroxylenol, ethyl alcohol and Chinese medical extract.
The beneficial effect for the Chinese medicine corrosion-proof and sterilization agent and preparation method thereof that present pre-ferred embodiments provide includes:
The Chinese medicine corrosion-proof and sterilization agent prescription that present pre-ferred embodiments provide is reasonable, can effectively be rapidly achieved disinfection and sterilization
Corrosion-resistant effect, can be used for include skin, mucous membrane, clothing, household, farm and epidemic situation protection etc. disinfection.Preparation method
Simply, time-consuming short, process is easily-controllable.
Specific embodiment
Chinese medicine corrosion-proof and sterilization agent provided in an embodiment of the present invention and preparation method thereof is specifically described below.
The application provides a kind of Chinese medicine corrosion-proof and sterilization agent, and according to parts by weight, the raw material of the Chinese medicine corrosion-proof and sterilization agent includes
The climbing groundsel of 20-30 parts by weight, the honeysuckle of 20-30 parts by weight, the chrysanthemum of 20-30 parts by weight, 20-30 parts by weight peppermint,
The ethyl alcohol of 15-25 parts by weight and 4-6 parts by weight to chloroxylenol.
In some preferred embodiments, raw material includes the gold and silver of the climbing groundsel of 22-28 parts by weight, 22-28 parts by weight
Flower, the chrysanthemum of 22-28 parts by weight, the peppermint of 22-28 parts by weight, the ethyl alcohol of 18-22 parts by weight and 4.5-5.5 parts by weight pair
Chloroxylenol.
In some preferred embodiments, raw material includes the climbing groundsel of 25 parts by weight, the honeysuckle of 25 parts by weight, 25
The chrysanthemum of parts by weight, the peppermint of 25 parts by weight, the ethyl alcohol of 20 parts by weight and 5 parts by weight to chloroxylenol.
Wherein, climbing groundsel is bitter in taste, trembles with fear, and return lung, liver, large intestine channel have clearing heat and detoxicating, and improving eyesight and antipruritic function control wind
Thermal sensation emits, red eye, swell pain, dysentery, skin eczema, boil.It has shiga's dysentery bar mattress and staphylococcus aureus
Stronger antibacterial action, to typhoid fever, paratyphoid A, paratyphoid B, dysentery (Freund, Boydii, sonnei), large intestine, deformation, cured sample charcoal
The bacillus such as subcutaneous ulcer and sarcine all have inhibitory or killing effect.But it is worth noting that climbing groundsel contains liver poison Pyrrolizidine alkaloid,
Its acute and chronic poisoning can cause the sinus hepaticus of liver to block syndrome, liver macrocytosis or liver fibrosis.
Honeysuckle nature and flavor are sweet, tremble with fear, enter lung, stomach meridian, there is effects for removing toxic heat, control warm disease heating, toxic-heat and blood stasis, and large carbuncle swells
Poison, scrofula, anal fistula.It is to the various pathogens such as hemolytic streptococcus, Staphylococcus aureus and infection of the upper respiratory tract Causative virus
Etc. there is stronger inhibitory or killing effect.
Chrysanthemum nature and flavor sweetness and bitterness, it is cool, enter lung, Liver Channel has dispelling wind, and disappear heat, improving eyesight, control headache, dizziness, hot eyes, ambition dysphoria with smothery sensation,
The effect of furunculosis.The application is mainly used for neutralizing and dissolving toxicity possessed by climbing groundsel, make as one of material composition
Chinese medicine corrosion-proof and sterilization agent is harmless to the human body.Preferably, chrysanthemum used herein is milli chrysanthemum, such chrysanthemum is in climbing groundsel
Contained liver poison Pyrrolizidine alkaloid has significant detoxifying effect.
Peppermint nature and flavor are pungent, cool, enter lung, Liver Channel, there is dispelling wind, and heat dissipation wards off dirty function, controls affection of exogenous wind-heat, have a headache, hot eyes,
Abscess of throat, food stagnation inflatable, aphtha, toothache, sore scabies, urticaria.In this application, on the one hand peppermint is used to play antibacterium, resists
On the other hand fungi and antiviral effect are also used to cooperate with chrysanthemum and play the role of eliminating toxicity to climbing groundsel.In addition, working as
When the application Chinese medicine corrosion-proof and sterilization agent is used for skin, peppermint can also promote drug ingedient to pass through keratoderma barrier, improve
Its transdermal rate, to play preferable Disinfection Effect.
Ethyl alcohol is dissolved mainly as solvent to chloroxylenol, by that will be dissolved in second to chloroxylenol in this application
Alcohol is capable of increasing chloroxylenol and climbing groundsel, honeysuckle, chrysanthemum and the contact area of peppermint, improves the speed of action.
Sterilization and antisepsis are played simultaneously in this application to chloroxylenol, to gram-positive bacteria, gram-negative
Property bacterium and mould all have preferable killing effect, and Chinese medicine corrosion-proof and sterilization agent provided herein can be made to answer in many sterilizations
It can be efficient in and avirulent plays a role.In addition, in ethanol can be to by climbing groundsel, honeysuckle, chrysanthemum to chloroxylenol
The colored and resulting Chinese medical extract of peppermint plays solubilization, increases alcohol solvent to the solubility of Chinese medical extract, is conducive to
Active constituent plays a role in Chinese medical extract, while it does not react with Chinese medical extract again and generates new compound, will not drop
The function and effect of low Chinese medical extract can cooperate the sterilization for improving the agent of Chinese medicine corrosion-proof and sterilization instead and be prevented with Chinese medical extract
It is rotten.
It holds, with climbing groundsel, honeysuckle, chrysanthemum, peppermint, ethyl alcohol and to chlorine two in the Chinese medicine corrosion-proof and sterilization agent of the application
Cresols is cooperated, so that each material medicine mutually generates synergistic effect, to be effectively rapidly achieved disinfection and sterilization corrosion-resistant effect
Fruit can refer to ground, and above-mentioned Chinese medicine corrosion-proof and sterilization agent is to staphylococcus aureus, hemolytic streptococcus, Escherichia coli, dysentery bar
Bacterium, comma bacillus, typhoid bacillus, paratyphosum Bacterium, pneumococcus, diplococcus meningitidis, Pseudomonas aeruginosa and tubercle bacillus etc.
There is suppression to kill effect.
In addition, can comprise the following steps that present invention also provides a kind of preparation method of above-mentioned Chinese medicine corrosion-proof and sterilization agent
Climbing groundsel, honeysuckle, chrysanthemum and peppermint are decocted, decoction liquor is obtained, is cooled to 40 DEG C hereinafter, adjusting pH value is 9-
10.5, it stands, collects supernatant, dehydration obtains Chinese medical extract.Mixing is to chloroxylenol, ethyl alcohol and Chinese medical extract.
Before decoction, it can stock up in the following manner to each raw material.Wherein, climbing groundsel: taking crude drug, removes impurity, washes
Only, it slightly dries in the air, dissection is dry.Honeysuckle: weeding out silt, picks net impurity.Chrysanthemum: net leaf stalk, anthocaulus and spare impurity are picked.Peppermint:
Pick net impurity, remove undesirable root, first by leaf tremble it is lower separately put, stem is then sprayed into clear water, rear dissection is moisturized, dries, then with leaf and even.
Then climbing groundsel, honeysuckle, chrysanthemum and the peppermint after stock are mixed according to the ratio, is decocted.In this application, it decocts
Boiling can carry out under conditions of 80-120 DEG C.Decoction also can be only 1 time, or repeatedly, for example, 2 times, 3 times or 3 times with
On, when it is multiple for decocting number, the rear primary resulting decoction dregs of a decoction after once being decocted before decocting object and being, eventually for
The total decoction liquor stood is the mixed liquor of the resulting decoction medical fluid after decocting every time.
In some embodiments, decocting number is 2 times, including decocts decoct with second for the first time.It decocts for the first time
It is by climbing groundsel, honeysuckle, chrysanthemum and the hybrid medicine of peppermint and water with weight ratio is that 1:7.5-9.5 is mixed, then first
Secondary cooking 80-100min is obtained and is cooked liquid for the first time.It is filtered for the first time with inorganic ceramic membrane, separation, impurity removal obtains the first filtrate and the
One filter residue.
It is to cook 50- second after mixing above-mentioned first filter residue for 1:5.5-6.5 with weight ratio with water that second, which decocts,
70min obtains second of cooking liquid.Second is filtered with second of hollow fiber ultrafiltration membrane and cooks liquid, obtains the second filtrate and the second filter
Slag.
In these cases, the total decoction liquor finally stood is the mixed liquor of the first filtrate Yu the second filtrate.If decocting
Number is greater than 2 times, and operation, which can refer to, decocts the step that number is 2 times.
In this application, before cooking for the first time and before cooking for second, the pH value for adjusting system to be cooked respectively is
4-5.It preferably, further include directly impregnating 30-40min after mixing hybrid medicine with water in water before cooking for the first time.
In this application, before standing, total decoction liquor is first cooled to 40 DEG C hereinafter, then adjusting the pH of decoction liquor with alkali
Value is 9-10.
It can refer to ground, time of repose can be 20-30min, after standing, cross 200 meshes, collect supernatant nanofiltration and anti-
Permeable membrane dehydration, concentration extraction active constituent, obtains Chinese medical extract.
Then chloroxylenol, ethyl alcohol and Chinese medical extract will be mixed.Preferably, chloroxylenol will be first dissolved in
In ethyl alcohol, then mixed again with Chinese medical extract.
Chinese medicine corrosion-proof and sterilization agent provided herein can effectively be rapidly achieved disinfection and sterilization corrosion-resistant effect, can be used for
Disinfection including skin, mucous membrane, clothing, household, farm and epidemic situation protection etc..It can refer to ground, which makes
With method can include:
(1), slight scuffing or abrasive wound are used in: taking Chinese medicine corrosion-proof and sterilization agent provided by the present application about 15mL
250mL water is added, clean a wound 3-5min, then uses dry gauze or bandaging.
(2), it is used in skin degerming: taking Chinese medicine corrosion-proof and sterilization agent provided by the present application about 15mL that 250mL water is added, use
This dilution rinses or embrocates 3-5min in the position that needs sterilize.
(3), it is used in mucous membrane disinfection: taking this product about 15mL that 600mL water is added, impregnate or embrocate 3-5min.
(4), it is used in clothing disinfection: taking this product about 60mL that 3000mL water is added, impregnated for underwear, coat, socks etc.
3-5min, the about 5min such as swimsuit, Children's diaper, rag, napkin, towel.
(5), the surface sterilizations such as floor, household are used in: Chinese medicine corrosion-proof and sterilization agent provided by the present application about 75mL being taken to be added
1250mL water, for cleaning household body surface 5min.
(6), lavatory, sink, irrigation canals and ditches, litter-bin, farm etc. are used in: taking appropriate Chinese medicine anti-corrosion provided by the present application
Disinfectant stock solution treats sterilising zone and rinses 5min.
(7), air-conditioning, automobile, workbench etc. are used in: Chinese medicine corrosion-proof and sterilization agent provided by the present application about 75mL being taken to be added
1250mL water, for cleaning household body surface 5min.
(8), be used in epidemic situation protection disinfection: Chinese medicine corrosion-proof and sterilization agent provided by the present application is dilute in the ratio and water of 1:100
It releases, impregnates, sprays or clean contactant, sterilize 10min.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
It stocks up in the following manner:
Climbing groundsel: taking crude drug, removes impurity, cleans, slightly dries in the air, and dissection is dry.Honeysuckle: weeding out silt, picks net miscellaneous
Matter.Milli chrysanthemum: net leaf stalk, anthocaulus and spare impurity are picked.Peppermint: picking net impurity, removes undesirable root, first by leaf tremble it is lower separately put, then
Stem is sprayed into clear water, rear dissection is moisturized, dries, then with leaf and even.
Mix the thin of the climbing groundsel of 25 parts by weight, the honeysuckle of 25 parts by weight, the chrysanthemum of 25 parts by weight and 25 parts by weight
Lotus obtains hybrid medicine.Hybrid medicine is mixed with water with weight ratio for 1:8, the pH value for adjusting mixed system is 4.5, is impregnated
Then 30min cooks 90min under conditions of 100 DEG C for the first time, obtain and cook liquid for the first time.With inorganic ceramic membrane first time mistake
Filter, separation, impurity removal obtain the first filtrate and the first filter residue.
First filter residue is mixed with water with weight ratio for 1:6, adjusting pH value is 4.5, then second under conditions of 100 DEG C
Secondary cooking 60min obtains second of cooking liquid.Filter second with hollow fiber ultrafiltration membrane second and cook liquid, obtain the second filtrate and
Second filter residue.
Above-mentioned first filtrate and the second filtrate are mixed, decoction liquor is obtained.Decoction liquor is cooled to 30 DEG C, alkali is added to adjust decoction liquor
PH value be 10, stand 25min, cross 200 mesh 2 times, collect supernatant, be dehydrated with nanofiltration and reverse osmosis membrane, concentration extraction is lived
Property ingredient, obtains Chinese medical extract.
By being dissolved in the ethyl alcohol of 20 parts by weight to chloroxylenol for 5 parts by weight, 10min is stirred, is obtained to xylene dichloride
Then phenol liquid is mixed with above-mentioned Chinese medical extract, obtain Chinese medicine corrosion-proof and sterilization agent.
Embodiment 2
It stocks up in the following manner:
Climbing groundsel: taking crude drug, removes impurity, cleans, slightly dries in the air, and dissection is dry.Honeysuckle: weeding out silt, picks net miscellaneous
Matter.Milli chrysanthemum: net leaf stalk, anthocaulus and spare impurity are picked.Peppermint: picking net impurity, removes undesirable root, first by leaf tremble it is lower separately put, then
Stem is sprayed into clear water, rear dissection is moisturized, dries, then with leaf and even.
Mix the thin of the climbing groundsel of 20 parts by weight, the honeysuckle of 20 parts by weight, the chrysanthemum of 20 parts by weight and 20 parts by weight
Lotus obtains hybrid medicine.Hybrid medicine is mixed with water with weight ratio for 1:7.5, the pH value for adjusting mixed system is 4, is impregnated
Then 30min cooks 100min under conditions of 80 DEG C for the first time, obtain and cook liquid for the first time.With inorganic ceramic membrane first time mistake
Filter, separation, impurity removal obtain the first filtrate and the first filter residue.
First filter residue is mixed with water with weight ratio for 1:5.5, adjusting pH value is 4, then second under conditions of 80 DEG C
Secondary cooking 100min obtains second of cooking liquid.Filter second with hollow fiber ultrafiltration membrane second and cook liquid, obtain the second filtrate and
Second filter residue.
Above-mentioned first filtrate and the second filtrate are mixed, decoction liquor is obtained.Decoction liquor is cooled to 38 DEG C, alkali is added to adjust decoction liquor
PH value be 9, stand 20min, cross 200 mesh 2 times, collect supernatant, be dehydrated with nanofiltration and reverse osmosis membrane, concentration extraction activity
Ingredient obtains Chinese medical extract.
By being dissolved in the ethyl alcohol of 15 parts by weight to chloroxylenol for 4 parts by weight, 10min is stirred, is obtained to xylene dichloride
Then phenol liquid is mixed with above-mentioned Chinese medical extract, obtain Chinese medicine corrosion-proof and sterilization agent.
Embodiment 3
It stocks up in the following manner:
Climbing groundsel: taking crude drug, removes impurity, cleans, slightly dries in the air, and dissection is dry.Honeysuckle: weeding out silt, picks net miscellaneous
Matter.Milli chrysanthemum: net leaf stalk, anthocaulus and spare impurity are picked.Peppermint: picking net impurity, removes undesirable root, first by leaf tremble it is lower separately put, then
Stem is sprayed into clear water, rear dissection is moisturized, dries, then with leaf and even.
Mix the thin of the climbing groundsel of 30 parts by weight, the honeysuckle of 30 parts by weight, the chrysanthemum of 30 parts by weight and 30 parts by weight
Lotus obtains hybrid medicine.Hybrid medicine is mixed with water with weight ratio for 1:9.5, the pH value for adjusting mixed system is 5, is impregnated
Then 40min cooks 80min under conditions of 120 DEG C for the first time, obtain and cook liquid for the first time.With inorganic ceramic membrane first time mistake
Filter, separation, impurity removal obtain the first filtrate and the first filter residue.
First filter residue is mixed with water with weight ratio for 1:6.5, adjusting pH value is 5, then second under conditions of 120 DEG C
Secondary cooking 80min obtains second of cooking liquid.Filter second with hollow fiber ultrafiltration membrane second and cook liquid, obtain the second filtrate and
Second filter residue.
Above-mentioned first filtrate and the second filtrate are mixed, decoction liquor is obtained.Decoction liquor is cooled to 25 DEG C, alkali is added to adjust decoction liquor
PH value be 9.5, stand 30min, cross 200 mesh 2 times, collect supernatant, be dehydrated with nanofiltration and reverse osmosis membrane, concentration extraction is lived
Property ingredient, obtains Chinese medical extract.
The menthol of 6 parts by weight is dissolved in the ethyl alcohol of 25 parts by weight, stirs 10min, obtain to chloroxylenol liquid, so
It is mixed afterwards with above-mentioned Chinese medical extract, obtains Chinese medicine corrosion-proof and sterilization agent.
Embodiment 4
The present embodiment the difference from embodiment 1 is that: in Chinese medicine corrosion-proof and sterilization agent raw materials used climbing groundsel be 22 parts by weight,
Honeysuckle is 28 parts by weight, milli chrysanthemum is 22 parts by weight, peppermint is 28 parts by weight, ethyl alcohol is 18 parts by weight and to xylene dichloride
Phenol is 5.5 parts by weight.
Embodiment 5
The present embodiment the difference from embodiment 1 is that: in Chinese medicine corrosion-proof and sterilization agent raw materials used climbing groundsel be 28 parts by weight,
Honeysuckle is 22 parts by weight, milli chrysanthemum is 28 parts by weight, peppermint is 22 parts by weight, ethyl alcohol is 22 parts by weight and to xylene dichloride
Phenol is 4.5 parts by weight.
Embodiment 6
The present embodiment the difference from embodiment 1 is that: decoct number be only 1 time.
Embodiment 7
The present embodiment the difference from embodiment 1 is that: decoct number be 3 times, for standing total decoction liquor be for the first time
The mixing of resulting first filtrate, the second filtrate and third filtrate respectively after decocting, decocting and decoct for the third time for second
Liquid.
Test example 1
Embodiment above-described embodiment 1-7 is repeated, enough Chinese medicine corrosion-proof and sterilization agent are obtained, in Anhui Province's disease prevention control
Center processed carries out Germicidal test and Simulation field test.
1. materials and methods
1.1 material
Given the test agent: Chinese medicine corrosion-proof and sterilization agent, weak yellow liquid, pH value 9.56, specific gravity 1.10g/mL are stored at room temperature,
Storage life 24 months.Purified water is configured to required concentration for examination.
Test strain: Escherichia coli (8099) 4-5 generation (strain source is in China General Microbiological Culture Collection Center),
The 3rd generation of staphylococcus aureus (ATCC6538) (strain source is in China General Microbiological Culture Collection Center), verdigris are false single
The 3rd generation of born of the same parents bacterium (ATCC15442) (strain source is in China General Microbiological Culture Collection Center), Candida albicans
(ATCC10231) 3-5 generation (strain source is in China General Microbiological Culture Collection Center).
Neutralization reagent: the TSB solution of+10g/L glycine+50g/L Tween-80 of lecithin containing 30g/L.
Dilution: the PBS solution containing 0.1% Tween 80.
Sterile cotton swab, dimension board (5cm × 5cm).
Ordinary nutrient agar culture medium, standard hard water.
1.2 method
1.2.1 Guantitative bactericidal test: quantitatively killing test method(s) using suspending, and test basis is referring to " disinfection technology rule
Model " the 2.1.1.7.4 articles of (version in 2002).The agent of Chinese medicine corrosion-proof and sterilization is to staphylococcus aureus, Escherichia coli, P. aeruginosa
The action time of bacterium is 1.5min, 3.0min and 4.5min, and the activity to staphylococcus aureus, Escherichia coli is
60 times of dilution, being to the activity of pseudomonas aeruginosa is 50 times of dilution；Experimental temperature is (20 ± 1) DEG C, and test repeats
Three times.
1.2.2 fungi quantitatively kills test: quantitatively killing test method(s) using suspending, test basis is referring to " disinfection technology rule
Model " the 2.1.1.7.4 articles of (version in 2002).The agent of Chinese medicine corrosion-proof and sterilization to action time of Candida albicans be 1.5min,
3.0min and 4.5min, activity be dilution 50 times and 60 times；Experimental temperature is 19 DEG C -21 DEG C, and test is in triplicate.
1.2.3 to surface disinfection field test: the 2.1.2.10 articles of reference " disinfection technology standard " (version in 2002)
Disinfectant is to other surfaces disinfection situ appraisal test.Body surface (desk tops, table top, door etc.) is taken at random, uses dimension board
The block that 2 pieces of areas are respectively 25cm is demarcated, one for sampling before sterilizing, another for sterilizing post-sampling.Before disinfection, by sterile cotton swab in
It is bedewed in the test tube of dilution containing 5mL, it is vertical and horizontal each 8 times round-trip to a region unit swabing sampling.After sampling, in a manner of sterile working
Cotton swab sampling end is cut in former dilution test tube, is shaken 80 times, as positive controls sample.Be dilution 20 times in
Medicine corrosion-proof and sterilization agent is embrocated to carry out disinfection in body surface, after disinfection 5min, by sterile cotton swab in the test tube of neutralizer containing 5ml
Middle adhesional wetting, it is vertical and horizontal each 8 times round-trip to sterile zones block swabing sampling.After sampling, in a manner of sterile working by cotton swab sampling end cut into
Disinfection group sample is used as in former sample solution test tube.By used same batch neutralizer, each 1.0mL inoculation medium of dilution, make
For negative control group.Experimental temperature is 19 DEG C -21 DEG C, relative humidity 52%-54%.
1.2.4 skin degerming effect field test: referring to " disinfection technology standard " (version in 2002) the 2.1.2.8 articles disinfection
Agent is to skin degerming field test.Before disinfection, allow subject by left and right inner forearm interrupt mutually sufficiently to stranding after, by dimension board
Section surface in being put on the inside of subject left forearm, is bedewed in the test tube of dilution containing 10ml with sterile cotton swab, in extracting on tube wall
Afterwards, swabing sampling is carried out in the region that dimension board is confined as positive controls sample: picking dilution 50 with sterile cotton swab
Chinese medicine corrosion-proof and sterilization dilution agent liquid again wipes the region that middle section surface specifications sheet frame is fixed on the inside of its right forearm and carries out disinfection, disappears
For toxic action 3min post-sampling as test group sample, the method for sampling is the same.After sampling, by cotton swab sub-sampling in a manner of sterile working
It cuts into progress count plate in sample solution test tube at end.Respectively by unworn with batch neutralizer, each 1.0ml of dilution, 2 parts of cotton swab
As negative control group sample.Detecting environment temperature is 22 DEG C, relative humidity 52%-54%.
2. result
2.1 Guantitative bactericidal test results
Under 19 DEG C of -21 DEG C of test temperatures, the agent of Chinese medicine corrosion-proof and sterilization is dense to the effect of staphylococcus aureus, Escherichia coli
Degree is 60 times of dilution, and the activity to pseudomonas aeruginosa is 50 times of dilution, to staphylococcus aureus, Escherichia coli, copper
The action time of green pseudomonad is 1.5min, 3.0min and 4.5min, averagely the killing equal > 5.00 of logarithm, and result is such as
Shown in table 1 to table 3.
Killing effect of the table 1 to staphylococcus aureus
Note: negative control group asepsis growth.
Killing effect of the table 2 to Escherichia coli
Note: negative control group asepsis growth.
Killing effect of the table 3 to pseudomonas aeruginosa
Note: negative control group asepsis growth.
2.2 fungies quantitatively kill test result
Under 19 DEG C of -21 DEG C of test temperatures, the agent of Chinese medicine corrosion-proof and sterilization is 50 times of dilutions to the activity of Candida albicans
Liquid, action time are 1.5min, 3.0min and 4.5min, averagely the killing equal > 4.00 of logarithm, and the results are shown in Table 4.
Killing effect of the table 4 to Candida albicans
Note: negative control group asepsis growth.
2.3 pairs of surface disinfection site test results
Show 20 times of Chinese medicine corrosion-proof and sterilization dilution agent through 30 parts of pattern detections, desktop, table top, door surface sterilization 5 are divided
Clock, to the equal > 1.00 of average killing logarithm of its surface natural bacteria, the results are shown in Table 5.
5 surface disinfection site test results of table
Note: negative control group asepsis growth.
2.4 skin degerming effect site test results
Show 50 times of diluted Chinese medicine corrosion-proof and sterilization agent opponent's skin of arm surface sterilization 3 minutes through 30 person-times of detections, it is right
Show the equal > 1.00 of average killing logarithm of natural bacteria, the results are shown in Table 6.
6 skin degerming site test results of table
Note: negative control group asepsis growth.
It holds, above-mentioned secondary test result shows with climbing groundsel, honeysuckle, chrysanthemum, four kinds of Chinese medicinal material extracts of peppermint and right
Chinese medicine corrosion-proof and sterilization agent made from chloxylenol preparation, under (20 ± 1) DEG C test temperature, 60 times of dilution, disinfection
Act on 1.5 minutes >s 5.00 equal to the average killing logarithm of staphylococcus aureus and Escherichia coli；50 times of dilution disappears
The toxic action 1.5 minutes average killing logarithm > 5.00 to pseudomonas aeruginosa, to the average killing logarithm of Candida albicans
Value > 4.00 sterilizes 30 person-times of surface of arm skin 3 minutes, to the average killing logarithm > 1.00 of surface natural bacteria；20
Dilution again, to the surface disinfections such as desktop, table top, door 5 minutes, to the average killing logarithm > of its surface natural bacteria
1.00。
Illustrate that Chinese medicine corrosion-proof and sterilization agent provided herein can be used for by the agent of Chinese medicine corrosion-proof and sterilization through diluting different proportion
The cleaning of sanitary washing, skin, mucous membrane, body surface and fabric etc., disinfection nursing, to bacterial propagule and fungi killing effect
It is relatively strong.
Test example 2
Contrast groups 1-3 is set, and contrast groups 1-3 and climbing groundsel, chrysanthemum and the content of peppermint in embodiment 1 are as shown in table 7.
7 content of table
Skin degerming is carried out according to the method for 1.2.4 in test example 1, the results are shown in Table 8.
8 skin degerming site test results of table
As can be seen from Table 8, climbing groundsel, chrysanthemum and peppermint there is certain collaboration to make sterilizing in the application
With.In addition, the Chinese medicine corrosion-proof and sterilization agent of contrast groups 1-3 all has different degrees of toxicity, 3 > contrast groups of toxicity intensity contrast groups
1 > contrast groups 2, but Chinese medicine corrosion-proof and sterilization agent provided by embodiment 1 does not have toxicity, illustrates that chrysanthemum and peppermint can be to a thousand lis
During toxicity plays possessed by light and/or detoxication.
Test example 3
By taking embodiment 1 as an example, contrast groups 4-5 is set, the chrysanthemum in contrast groups 4 is camomile, and the chrysanthemum in contrast groups 5 is open country
Chrysanthemum, remaining condition are all the same.On the basis of the liver poison Pyrrolizidine alkaloid W1 of climbing groundsel in each group, embodiment is measured
The amount W2 of liver poison Pyrrolizidine alkaloid contained in Chinese medicine corrosion-proof and sterilization agent corresponding to 1 and contrast groups 4-5, by removing toxic substances rate
=(W2-W1)/W1 calculates the removing toxic substances rate of each group, and result presses embodiment 1, contrast groups 4 and contrast groups 4 successively are as follows: 100%,
78.3% and 61.0%.
It can thus be seen that milli chrysanthemum employed in the application can more other types chrysanthemum provided herein
Liver poison Pyrrolizidine alkaloid contained by raw material climbing groundsel can be sufficiently neutralized under the mating reaction of each raw material, avoid Chinese medicine anti-corrosion
Disinfectant generates adverse effect to human body.
In conclusion the Chinese medicine corrosion-proof and sterilization agent prescription that the application preferred embodiment provides is reasonable, effectively can quickly reach
To disinfection and sterilization corrosion-resistant effect, can be used for include skin, mucous membrane, clothing, household, farm and epidemic situation protection etc. disinfection.
Preparation method is simple, and time-consuming short, process is easily-controllable.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine corrosion-proof and sterilization agent, which is characterized in that according to parts by weight, the raw material of the Chinese medicine corrosion-proof and sterilization agent includes
The climbing groundsel of 20-30 parts by weight, the honeysuckle of 20-30 parts by weight, the chrysanthemum of 20-30 parts by weight, 20-30 parts by weight peppermint,
The ethyl alcohol of 15-25 parts by weight and 4-6 parts by weight to chloroxylenol.
2. Chinese medicine corrosion-proof and sterilization agent according to claim 1, which is characterized in that the raw material includes 22-28 parts by weight
The climbing groundsel, the honeysuckle of 22-28 parts by weight, the chrysanthemum of 22-28 parts by weight, 22-28 parts by weight it is described thin
Lotus, the ethyl alcohol of 18-22 parts by weight and 4.5-5.5 parts by weight to chloroxylenol.
3. Chinese medicine corrosion-proof and sterilization agent according to claim 2, which is characterized in that the raw material includes the described of 25 parts by weight
Climbing groundsel, the honeysuckle of 25 parts by weight, the chrysanthemum of 25 parts by weight, the peppermints of 25 parts by weight, 20 parts by weight
The ethyl alcohol and 5 parts by weight to chloroxylenol.
4. Chinese medicine corrosion-proof and sterilization agent according to claim 1-3, which is characterized in that the chrysanthemum is milli chrysanthemum.
5. a kind of preparation method of Chinese medicine corrosion-proof and sterilization agent according to any one of claims 1-4, which is characterized in that including with
Lower step:
The climbing groundsel, the honeysuckle, the chrysanthemum and the peppermint are decocted, decoction liquor is obtained, is cooled to 40 DEG C hereinafter, adjusting
Section pH value is 9-10.5, is stood, and supernatant is collected, and dehydration obtains Chinese medical extract；
It mixes described to chloroxylenol, the ethyl alcohol and the Chinese medical extract.
6. preparation method according to claim 5, which is characterized in that decoction carries out under conditions of 80-120 DEG C.
7. preparation method according to claim 5, which is characterized in that decocting includes decocting to decoct with second for the first time；
Decoct for the first time be by the climbing groundsel, the honeysuckle, the chrysanthemum and the hybrid medicine of the peppermint and water with
Weight ratio is to cook 80-100min for the first time after 1:7.5-9.5 is mixed, and obtains and cooks liquid for the first time, filters for the first time, obtain the first filter
Liquid and the first filter residue；
It is to cook 50- second after mixing first filter residue for 1:5.5-6.5 with weight ratio with water that second, which decocts,
70min obtains second of cooking liquid, and second of filtering obtains the second filtrate and the second filter residue；
The decoction liquor is the mixed liquor of first filtrate and second filtrate.
8. preparation method according to claim 7, which is characterized in that before cooking for the first time and before cooking for second, adjust
The pH value for saving system to be cooked is 4-5.
9. preparation method according to claim 7, which is characterized in that further include by the mixing medicine before cooking for the first time
Object impregnates 30-40min in water.
10. preparation method according to claim 5, which is characterized in that first mix described to chloroxylenol and described
Then ethyl alcohol is mixed with the Chinese medical extract again.
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|---|---|---|---|---|
| WO2013016656A1 (en) * | 2011-07-28 | 2013-01-31 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to skin disorders |
| CN102440266A (en) * | 2011-11-02 | 2012-05-09 | 安徽亿人安卫生科技有限公司 | Chinese traditional medicine preparation for antibiosis, bactriostasis and sterilization and preparation method thereof |
| CN103891784A (en) * | 2013-09-11 | 2014-07-02 | 安徽亿人安有限公司 | Bacteriostatic agent for sterilization and disinfection, skin mucosa disinfection fluid and preparation method thereof |
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Application publication date: 20190125 |