CN109200370B - Body cavity liquid treatment device - Google Patents

Abstract

The invention provides a body cavity liquid processing device which can accurately grasp the timing of cleaning a filter and can automatically clean the filter. The ascites processing device comprises a filter, a first pipeline, a second pipeline, a cleaning solution storage part, a cleaning pipeline, a cleaning opening and closing device, a pump, a first pressure measuring device, a second pressure measuring device, a first opening and closing device, a second opening and closing device, an upstream opening and closing device and a control device. The control device is configured to, based on a pressure difference between the pressure measured by the first pressure measuring device and the pressure measured by the second pressure measuring device, reverse the pump in a state where the cleaning opening/closing device and the first opening/closing device are opened and the second opening/closing device and the upstream opening/closing device are closed when the pressure difference exceeds a predetermined threshold value, and supply the cleaning liquid in the cleaning liquid storage portion to the filtration membrane through the cleaning line and the second line.

Description

Body cavity liquid treatment device

Technical Field

The invention relates to a body cavity liquid treatment device.

Background

As a method for treating refractory Ascites, there is an Ascites filtration-Concentrated intravenous infusion Therapy (Cell-free and Concentrated analytes infusion Therapy): removing ascites from a patient, removing causative substances such as bacteria and cancer cells from the ascites, removing water from the ascites while leaving useful components such as albumin, and returning the water-removed concentrate to the body.

In the above-mentioned treatment method, an ascites treatment device is generally used. The ascites treatment apparatus employs the following structure: the ascites bag, the filter, the concentrator and the concentrated ascites bag are connected in series in this order, and ascites is filtered and concentrated by flowing the ascites by using a drop head or a pump. The filter uses a filtration membrane such as a hollow fiber membrane.

In addition, since ascites contains many removed substances to be removed by the filter, the filter membrane of the filter may be clogged in a short time in the treatment of ascites using the ascites treatment apparatus. Therefore, it has been proposed to provide a function of cleaning a filtration membrane of a filter in an ascites treatment apparatus (see patent document 1).

Patent document 1: japanese patent laid-open publication No. 2015-126763

Disclosure of Invention

Problems to be solved by the invention

However, in the ascites treatment apparatus having the above-described function of cleaning the filtration membrane, it is difficult to accurately grasp the timing at which the filtration membrane of the filter is clogged and cleaning is required. If the timing for cleaning the filtration membrane is delayed, excessive pressure is applied to the filtration membrane, which may cause deterioration or breakage of the filtration membrane. In addition, when cleaning the filtration membrane, medical staff is required to perform the cleaning operation each time, which takes time and labor.

The present invention has been made in view of the above-described problems, and an object thereof is to provide a body fluid treatment apparatus such as an ascites treatment apparatus, which can accurately grasp the timing of cleaning a filter and can automatically clean the filter.

Means for solving the problems

As a result of intensive studies, the inventors of the present invention have found that the above object can be achieved by providing a body cavity fluid treatment apparatus with a cleaning fluid storage section, a cleaning line, a pump, a first pressure measurement device, a second pressure measurement device, a control device, and the like, and have completed the present invention.

That is, the present invention includes the following aspects.

(1) A body cavity fluid treatment device at least comprises: a filter having a filtering membrane, and filtering a body cavity liquid by passing the body cavity liquid through the filtering membrane; a first line communicating with an inlet side of a filtering membrane of the filter for flowing a body cavity liquid through the filtering membrane; a second line communicating with an outlet side of the filtration membrane of the filter, through which a filtrate volume having passed through the filtration membrane flows; a cleaning device connected to the second line, and configured to supply a cleaning liquid to an outlet side of the filtration membrane through the second line, and to clean the filtration membrane by passing the cleaning liquid through the filtration membrane; a pump that is provided on the upstream side of the second line from the position where the cleaning device is connected, and that sucks the body cavity liquid of the first line to the filter by normal rotation, and supplies the cleaning liquid of the cleaning device to the outlet side of the filtration membrane through the second line by reverse rotation and passes the cleaning liquid through the filtration membrane; a pressure measuring device that measures a pressure on an outlet side of the filtration membrane of the filter; a third line communicating with an inlet side of the filter and discharging the cleaning liquid having passed through the filtration membrane; a first opening/closing device provided in the third pipeline; a second opening/closing device provided on the second line downstream of a position connected to the cleaning device; an upstream opening/closing device provided in the first pipeline; and a control device that, when a value based on the pressure measured by the pressure measurement device exceeds a predetermined threshold value, reverses the pump in a state where the first opening/closing device is opened and the second opening/closing device and the upstream opening/closing device are closed, and supplies the cleaning liquid to the filtration membrane through the second line by the cleaning device. The "state in which the cleaning opening/closing means and the first opening/closing means are opened and the second opening/closing means and the upstream opening/closing means are closed" may be a state in which the cleaning solution is supplied to the filtration membrane through the second line by the cleaning apparatus by at least reversing the pump, and may include a case in which the state is previously set and a case in which the state is set at the time of supply. The "value based on the pressure measured by the pressure measuring device" may be a value obtained by using at least "the pressure measured by the pressure measuring device", and the "pressure measured by the pressure measuring device" includes a value calculated from the pressure and other pressures.

(2) The body cavity fluid treatment apparatus according to (1), wherein the cleaning device comprises: a cleaning liquid storage part for storing a cleaning liquid; a cleaning line connecting the cleaning solution storage part and the second line; and a cleaning opening/closing device provided in the cleaning line.

(3) In the body cavity liquid treatment apparatus described in (1) or (2), the control device decreases the flow rate of the normal rotation of the pump and continues to supply the body cavity liquid to the filter when the value based on the pressure at least once first exceeds the threshold value, and the control device reversely rotates the pump to supply the cleaning liquid to the filtration membrane in a state where the first opening/closing device is opened and the second opening/closing device and the upstream opening/closing device are closed when the value based on the pressure thereafter exceeds the threshold value.

(4) In the body cavity fluid treatment apparatus described in (3), when the flow rate of the normal rotation of the pump reaches a predetermined minimum flow rate and the value based on the pressure exceeds the threshold value, the control device may reversely rotate the pump to supply the cleaning fluid to the filtration membrane in a state where the first opening/closing device is opened and the second opening/closing device and the upstream opening/closing device are closed.

(5) In the body cavity fluid treatment apparatus according to any one of (1) to (4), the control device supplies the cleaning fluid to the outlet side of the filtration membrane by the pump with the first opening/closing device, the second opening/closing device, and the upstream opening/closing device closed, and raises the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than a predetermined pressure, and then opens the first opening/closing device to allow the cleaning fluid to pass through the filtration membrane.

(6) In the body cavity fluid treatment apparatus according to (5), the control unit repeats the following operations a plurality of times: the pressure on the outlet side of the filtration membrane of the filter is increased to a pressure not lower than a predetermined pressure, and then the cleaning liquid is passed through the filtration membrane.

(7) In the body cavity liquid treatment apparatus described in (6), after repeating the operation of causing the cleaning liquid to pass through the filtration membrane after increasing the pressure on the outlet side of the filtration membrane of the filter to a pressure equal to or higher than a predetermined pressure a plurality of times, the control device supplies the cleaning liquid to the outlet side of the filtration membrane by the pump in a state where the first opening/closing device is opened and the second opening/closing device and the upstream opening/closing device are closed, and causes the cleaning liquid to pass through the filtration membrane without increasing the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than the predetermined pressure.

(8) A body cavity fluid treatment device at least comprises: a filter having a filtering membrane, and filtering a body cavity liquid by passing the body cavity liquid through the filtering membrane; a first line communicating with an inlet side of a filtering membrane of the filter for flowing a body cavity liquid through the filtering membrane; a second line communicating with an outlet side of the filtration membrane of the filter, through which a filtrate volume having passed through the filtration membrane flows; a pump disposed in the second line for drawing the body cavity fluid of the first line to the filter; a cleaning device connected to the second line upstream of the pump, for supplying a cleaning liquid to the outlet side of the filtration membrane through the second line and cleaning the filtration membrane through the filtration membrane; a pressure measuring device that measures a pressure on an outlet side of the filtration membrane of the filter; a third line communicating with an inlet side of the filter and discharging the cleaning liquid having passed through the filtration membrane; a first opening/closing device provided in the third pipeline; an upstream opening/closing device provided in the first pipeline; and a control device that, when a value based on the pressure measured by the pressure measurement device exceeds a predetermined threshold value, supplies the cleaning liquid to the filtration membrane through the second line by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed. The "state in which the pump is stopped, the first opening/closing means is opened, and the upstream opening/closing means is closed" may be a state in which the cleaning liquid is supplied to the filtration membrane through at least the second line by the cleaning apparatus, and may include a case in which the state is previously set and a case in which the state is set at the time of supply. The "value based on the pressure measured by the pressure measuring device" may be a value obtained by using at least "the pressure measured by the pressure measuring device", and the "pressure measured by the pressure measuring device" may include a value calculated based on the pressure and other pressures.

(9) The body cavity fluid treatment apparatus according to (8), wherein the cleaning device comprises: a cleaning liquid storage part for storing a cleaning liquid; a cleaning line connecting the cleaning solution storage part and the second line; and a cleaning pump provided in the cleaning line for supplying the cleaning liquid.

(10) In the body cavity liquid treatment apparatus described in (8) or (9), the control device decreases the flow rate of the pump and continues to supply the body cavity liquid to the filter when the value based on the pressure at least once first exceeds the threshold value, and the control device supplies the cleaning liquid to the filtration membrane by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed when the value based on the pressure thereafter exceeds the threshold value.

(11) In the body cavity fluid treatment apparatus described in (10), when the flow rate of the pump reaches a predetermined minimum flow rate and the value based on the pressure exceeds the threshold value, the control device supplies the cleaning fluid to the filtration membrane by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed.

(12) In the body cavity liquid treatment apparatus according to any one of (8) to (11), the control device supplies the cleaning liquid to the outlet side of the filtration membrane by the cleaning pump and increases the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than a predetermined pressure in a state where the pump is stopped and the first opening/closing device and the upstream opening/closing device are closed, and then opens the first opening/closing device to allow the cleaning liquid to pass through the filtration membrane.

(13) The body cavity fluid treatment apparatus according to (12), wherein said control unit repeats the following operations a plurality of times: the pressure on the outlet side of the filtration membrane of the filter is increased to a pressure not lower than a predetermined pressure, and then the cleaning liquid is passed through the filtration membrane.

(14) In the body cavity liquid treatment apparatus described in (13), after repeating the operation of causing the cleaning liquid to pass through the filtration membrane after increasing the pressure on the outlet side of the filtration membrane of the filter to a pressure equal to or higher than a predetermined pressure a plurality of times, the control device supplies the cleaning liquid to the outlet side of the filter by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed, and causes the cleaning liquid to pass through the filtration membrane without increasing the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than the predetermined pressure.

(15) The body cavity liquid treatment apparatus according to any one of (1) to (14), further comprising a recovery device for recovering the filtered body cavity liquid remaining on the outlet side of the filtration membrane of the filter through the second line.

(16) The body cavity liquid treatment apparatus according to (15), wherein the recovery device comprises a recovery line communicating with the outlet side of the filtration membrane, a recovery opening/closing device provided in the recovery line, and a fluid supply device for supplying a fluid to the recovery line.

(17) The body cavity liquid processing apparatus according to (16), wherein said fluid is a gas, and a gas detection device is provided in said second line.

(18) The body cavity fluid treatment apparatus according to any one of (1) to (17), wherein the filtration membrane is a hollow fiber membrane, an inlet side of the filtration membrane is an inner region of the hollow fiber membrane, and an outlet side of the filtration membrane is an outer region of the hollow fiber membrane.

(19) The body cavity fluid treatment apparatus according to any one of (1) to (17), wherein the filtration membrane is a hollow fiber membrane, an outlet side of the filtration membrane is an inner region of the hollow fiber membrane, and an inlet side of the filtration membrane is an outer region of the hollow fiber membrane.

(20) The body cavity liquid treatment apparatus according to any one of (1) to (19), further comprising a concentration system for concentrating the filtered body cavity liquid in the second line.

(21) The body cavity fluid treatment apparatus according to (20), wherein the concentration system comprises: a concentrator for concentrating the filtered body fluid of the second line; a concentration line through which a concentrated body fluid concentrated by the concentrator flows; a drain line for draining the moisture removed by the concentrator; and a concentration pump provided to the concentration line or the drain line.

(22) The body cavity fluid treatment apparatus according to (21), wherein the concentration system further comprises: a concentrated body cavity liquid storage unit that stores the concentrated body cavity liquid; and a circulation line for returning the concentrated body fluid in the concentrated body fluid storage portion to the second line.

ADVANTAGEOUS EFFECTS OF INVENTION

According to the present invention, it is possible to provide a body cavity fluid treatment apparatus capable of accurately grasping the timing of cleaning a filter and automatically cleaning the filter.

Drawings

Fig. 1 is an explanatory diagram showing an outline of the configuration of an ascites treatment device in the first embodiment.

FIG. 2 is an explanatory view showing a state of the ascites treatment apparatus in the re-concentration step in the first embodiment.

Fig. 3 is an explanatory diagram showing a main control flow of ascites treatment.

Fig. 4 is an explanatory diagram illustrating a state of the ascites treatment apparatus in the recovery process in the first embodiment.

Fig. 5 is an explanatory diagram illustrating a state of the ascites treatment apparatus in the cleaning step in the first embodiment.

Fig. 6 is an explanatory diagram showing an outline of the configuration of the ascites treatment device in the second embodiment.

FIG. 7 is an explanatory view showing a state of an ascites processing apparatus in the recovery process in the second embodiment.

FIG. 8 is an explanatory view showing a state of an ascites treatment apparatus in the cleaning step in the second embodiment.

Fig. 9 is an explanatory diagram showing a state of the ascites treatment device at the time of pulse cleaning in the first embodiment.

Fig. 10 is an explanatory diagram showing a state of the ascites treatment device at the time of pulse cleaning in the second embodiment.

Fig. 11 is an explanatory diagram showing a relationship between the pressure difference between the membranes and the flow rate of the pump.

Fig. 12 is an explanatory diagram showing an outline of the configuration of another ascites processing apparatus according to the first embodiment and the second embodiment.

Fig. 13 is an explanatory view showing a situation of a re-concentration process of another ascites treatment apparatus in the first and second embodiments.

Fig. 14 is an explanatory diagram illustrating a case of a cleaning process of another ascites treatment apparatus in the first and second embodiments.

Fig. 15 is an explanatory diagram showing an outline of the configuration of the ascites treatment device in the third embodiment.

FIG. 16 is an explanatory view showing a state of an ascites treatment apparatus in the re-concentration step in the third embodiment.

FIG. 17 is an explanatory view showing a state of an ascites treatment apparatus in the recovery step in the third embodiment.

FIG. 18 is an explanatory view showing a state of an ascites treatment apparatus in the cleaning step in the third embodiment.

Fig. 19 is an explanatory diagram showing an outline of the configuration of the ascites treatment device in the fourth embodiment.

FIG. 20 is an explanatory view showing a state of an ascites treatment apparatus in the recovery step in the fourth embodiment.

FIG. 21 is an explanatory view showing a state of an ascites treatment apparatus in the cleaning step in the fourth embodiment.

Fig. 22 is an explanatory diagram showing a state of the ascites treatment device at the time of pulse cleaning in the third embodiment.

Fig. 23 is an explanatory diagram showing a state of the ascites treatment device at the time of pulse cleaning in the fourth embodiment.

Fig. 24 is an explanatory diagram showing another connection example of the circulation line in the third embodiment.

FIG. 25 is an explanatory view showing a state of an ascites treating apparatus in a re-concentration step in another connection example of the circulation line.

Fig. 26 is an explanatory diagram showing an outline of the configuration of the ascites treatment device in the case where the third line is connected to the first line in the second embodiment.

Fig. 27 is an explanatory diagram showing an outline of the configuration of the ascites treatment device in the case where the third line is connected to the first line in the fourth embodiment.

Description of the reference numerals

1: an ascites management device; 10: a belly water bag; 11: a filter; 12: a first pipeline; 13: a second pipeline; 14: a third pipeline; 15: a fourth pipeline; 16: a first pressure measuring device; 17: a second pressure measuring device; 18: a pump; 19: a first opening/closing device; 20: a second opening/closing device; 30: a cleaning liquid storage section; 31: cleaning the pipeline; 32: cleaning the opening and closing device; 33: cleaning the pump; 40: a recovery device; 50: a control device; 60: a concentration system; 70: a filtration membrane; 110: a concentrator; 111: a condensed belly water bag; 112: a concentrate line; 113: a drain line; 114: a recycle line; 115: a concentration pump; 116: and a circulating pump.

Detailed Description

Preferred embodiments of the present invention will be described below with reference to the accompanying drawings. Note that the same elements are denoted by the same reference numerals, and redundant description thereof is omitted. The positional relationship between the upper, lower, left, and right sides is not particularly limited, unless otherwise specified. The dimensional ratios in the drawings are not limited to the illustrated ratios. The following embodiments are illustrative of the present invention, and the present invention is not limited to these embodiments.

(first embodiment)

Fig. 1 is an explanatory diagram showing an outline of the configuration of an ascites treatment device 1 as a body cavity fluid treatment device according to the present embodiment.

The ascites treating apparatus 1 includes an ascites bag 10 as an ascites storing section, a filter 11, a first line 12, a second line 13, a third line 14, a fourth line 15, a first pressure measuring device 16, a second pressure measuring device 17, a pump 18, a first opening/closing device 19, a second opening/closing device 20, an upstream opening/closing device 21, a cleaning liquid storing section 30, a cleaning line 31, a cleaning opening/closing device 32, a collecting device 40, a control device 50, a concentration system 60, and the like.

The abdominal water bag 10 can contain ascites extracted from the patient.

The filter 11 has, for example, a cylindrical shape. The filter 11 has liquid inlets 11a and 11b at both ends in the longitudinal direction, and two liquid inlets 11c and 11d on the side surface.

The filter 11 includes a filtration membrane 70 such as a hollow fiber membrane, and the filtration membrane 70 is used to remove a predetermined causative substance such as bacteria and cancer cells and to pass a predetermined useful component such as albumin. The inner region of the filtration membrane 70 communicates with the liquid inlet ports 11a and 11b, and the outer region of the filtration membrane 70 communicates with the liquid inlet ports 11c and 11 d.

A first line 12 connects the belly bag 10 with the filter 11. The downstream end of the first line 12 is connected to a liquid inlet 11a of the filter 11.

The second line 13 connects the filter 11 to a later-described concentrator 110 of the concentration system 60. The upstream end of the second line 13 is connected to the liquid inlet 11c of the filter 11.

One end of the third line 14 is connected to the liquid inlet 11b of the filter 11. The other end of the third line 14 is connected to, for example, a drain portion not shown.

One end of the fourth line 15 is connected to the liquid inlet 11d of the filter 11. The other end of the fourth line 15 is open to the atmosphere. In addition, soft tubes are used for the first to fourth lines 12 to 15.

The first pressure measuring device 16 is provided in the first line 12, and is capable of measuring the pressure on the primary side (inlet side) of the filtration membrane 70 of the filter 11. The second pressure measuring device 17 is provided in the fourth line 15, and is capable of measuring the pressure on the secondary side (outlet side) of the filtration membrane 70 of the filter 11. The pressure measurement result of the first pressure measuring device 16 and the pressure measurement result of the second pressure measuring device 17 are output to the control device 50.

A pump 18 is arranged in the second line 13. The pump 18 is, for example, a tube pump capable of performing normal rotation and reverse rotation for pressurizing ascites in a delivery tube by treating the tube. The pump 18 also functions as an opening/closing device (flow rate adjustment device) for opening the second line 13 during operation and closing the second line 13 during stoppage.

The first opening/closing device 19 is, for example, an opening/closing valve, and is provided in the third line 14. The second opening/closing device 20 is, for example, an opening/closing valve, and is provided in the second line 13.

The upstream opening/closing device 21 is, for example, an opening/closing valve, and is provided in the first line 12. The cleaning liquid storage section 30 is, for example, a soft bag and can store a predetermined amount of cleaning liquid. The cleaning liquid is, for example, brine.

The cleaning line 31 connects the cleaning solution storage portion 30 with the second line 13. The cleaning line 31 is connected to, for example, the second line 13 at a position upstream (filter 11 side) of the second opening/closing device 20. The cleaning line 31 is made of, for example, a soft tube. The cleaning opening/closing device 32 is, for example, an opening/closing valve, and is provided in the cleaning line 31. In the present embodiment, the cleaning device includes a cleaning opening/closing device 32, a cleaning line 31, and a cleaning storage unit 30.

The recovery device 40 recovers the filtered ascites (filtered ascites) remaining at the outlet side of the filtering membrane 70 of the filter 11 through the second line 13. The recovery device 40 includes, for example, a fluid supply device, and includes, for example, a fourth line 15 having one end connected to the liquid inlet 11d of the filtration membrane 70 and the other end opened to the atmosphere, and a recovery opening/closing device 90 provided in the fourth line 15. Thus, the recovery device 40 can supply gas (air) to the outlet side of the filtration membrane 70 by opening the recovery opening/closing device 90 and driving the pump 18, thereby pushing the filtered ascites on the outlet side of the filtration membrane 70 out to the second line 13.

A gas detection device 91 is provided on the second line 13. The gas detection device 91 is provided upstream (on the filter 11 side) of the connection portion of the purge line 31. This makes it possible to detect that the outlet side of the filtration membrane 70 is replaced with gas by the recovery device 40 and that the filtered ascites on the outlet side of the filtration membrane 70 is discharged to the second line 13.

The control device 50 is, for example, a microcomputer having a CPU, a memory, and the like. The control device 50 can control the operations of the respective devices such as the pump 18, the first opening/closing device 19, the second opening/closing device 20, the upstream opening/closing device 21, the cleaning opening/closing device 32, the first pressure measurement device 16, the second pressure measurement device 17, the recovery opening/closing device 90 of the recovery device 40, the gas detection device 91, and the concentration system 60, and perform ascites treatment. The control device 50 can execute, for example, a program stored in advance in a memory to perform ascites treatment.

Specifically, for example, the control device 50 reverses the pump 18 to supply the cleaning liquid in the cleaning liquid storage section 30 to the filtration membrane 70 through the cleaning line 31 and the second line 13, with the cleaning opening/closing device 32 and the first opening/closing device 19 opened and the second opening/closing device 20 and the upstream opening/closing device 21 closed, when the pressure difference exceeds a predetermined threshold value, based on the pressure difference between the pressure measured by the first pressure measuring device 16 and the pressure measured by the second pressure measuring device 17.

The concentration system 60 includes a concentrator 110, a concentrated ascites bag 111 as a concentrated ascites reservoir, a concentration line 112, a drain line 113, a circulation line 114, a concentration pump 115, a circulation pump 116, a third pressure measurement device 117, a fourth pressure measurement device 118, and the like.

The concentrator 110 has, for example, a cylindrical shape. The concentrator 110 has liquid inlets 110a and 110b at both ends in the longitudinal direction, and two liquid inlets 110c and 110d on the side surface. For example, the second line 13 is connected to the liquid inlet 110a of the concentrator 110.

The concentrator 110 includes a concentration membrane 120 such as a hollow fiber membrane, and the concentration membrane 120 is used to remove water from the filtered ascites supplied from the second line 13, for example, to concentrate the filtered ascites. The inner region of the concentrating membrane 120 communicates with the liquid inlets 110a and 110b, and the outer region of the concentrating membrane 120 communicates with the liquid inlets 110c and 110 d. In the present embodiment, the liquid passage port 110d is closed.

The concentrated ascites bag 111 can contain concentrated ascites concentrated by the concentrator 110. The concentration line 112 connects the liquid passing port 110b of the concentrator 110 with the concentrated ascites bag 111. One end of the drain line 113 is connected to the liquid inlet 110c of the concentrator 110, and the other end is connected to a drain unit, not shown.

The circulation line 114 connects, for example, the concentrate bag 111 with the second line 13. The circulation line 114 is connected to the second line 13 at a position downstream of the second opening/closing device 20 (on the concentrator 110 side). For example, soft tubes are used for the concentrate line 112, the drain line 113, and the circulation line 114.

The concentration pump 115 is provided in the concentration line 112, for example. A circulation pump 116 is disposed in the circulation line 114. The concentration pump 115 and the circulation pump 116 are, for example, tube pumps.

The third pressure measuring device 117 is provided in the second line 13, for example, and can measure the pressure on the primary side (inlet side) of the concentration membrane 120 of the concentrator 110. The fourth pressure measuring device 118 is provided in the drain line 113, and can measure the pressure on the secondary side (outlet side) of the concentration membrane 120 of the concentrator 110. The pressure measurement result of the third pressure measuring device 117 and the pressure measurement result of the fourth pressure measuring device 118 are output to the control device 50. The control device 50 can control the operations of the respective devices of the concentration system 60, such as the concentration pump 115, the circulation pump 116, the third pressure measurement device 117, and the fourth pressure measurement device 118, and execute ascites treatment.

Next, ascites treatment using the ascites treatment device 1 will be described.

First, as shown in fig. 1, an ascites bag 10 containing ascites fluid extracted from a patient is connected to a first line 12. Then, the ascites filtration and concentration step is started. In a state where the first opening/closing device 19 is closed and the second opening/closing device 20 and the upstream opening/closing device 21 are opened, the pump 18 is rotated in the normal direction, and the concentration pump 115 is operated. The cleaning opening/closing device 32 is kept closed, the recovery opening/closing device 90 of the recovery device 40 is closed, and the circulation pump 116 is kept stopped.

Thereby, ascites in the ascites bag 10 is transported to the filter 11 through the first line 12. The ascites flows into the inlet side (inner region) of the filtration membrane 70 from the fluid inlet 11a of the filter 11, passes through the filtration membrane 70, and then flows out to the outlet side (outer region) of the filtration membrane 70. At this time, a predetermined causative substance is removed from the ascites. The filtered ascites flowing out to the outlet side of the filtering membrane 70 flows out from the filter 11 to the second line 13, is transferred to the concentrator 110 through the second line 13 and flows into the inlet side of the concentrating membrane 120 of the concentrator 110. Here, a part of the moisture of, for example, the filtered ascites flows out to the outlet side of the concentration membrane 120 through the concentration membrane 120 by the pressure difference (flow rate difference) between the pump 18 and the concentration pump 115. Thereby, water is removed from the filtrated ascites, and the filtrated ascites is concentrated. The concentrated ascites concentrated by the concentrator 110 is received in the concentrated ascites bag 111 through the concentration line 112. When a predetermined amount of concentrated ascites is stored in the concentrated ascites bag 111, the pump 18 is stopped, and the filtration and concentration steps are ended.

Subsequently, for example, a re-concentration step is performed. At this time, as shown in fig. 2, the circulation pump 116 and the concentration pump 115 are operated in a state where the second opening/closing device 20 is closed with the pump 18 stopped. Thereby, the concentrated ascites in the concentrated ascites bag 111 is transferred to the concentrator 110 through the circulation line 114 and the second line 13, and returned from the concentrator 110 to the concentrated ascites bag 111 through the concentration line 112 to be circulated. The concentrated ascites is then concentrated to produce concentrated ascites of a desired concentration.

In the step of filtering and concentrating ascites, the first pressure measuring device 16 and the second pressure measuring device 17 are operated to monitor the pressure on the inlet side and the pressure on the outlet side of the filtration membrane 70 of the filter 11. As shown in fig. 3, for example, when the pressure difference (P1-P2) (the pressure difference between membranes) (the value based on the pressure measured by the second pressure measuring device 17) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the filter 11 exceeds a predetermined threshold value D, the filtration membrane 70 is deemed to be clogged, the upstream opening/closing device 21 is closed, and the process of filtering and concentrating ascites is stopped. The threshold value D is obtained and set in advance by experiments and calculations. Fig. 3 shows a main control flow when the cleaning process is performed.

Subsequently, for example, as shown in fig. 4, the filtered ascites remaining on the outlet side of the filtration membrane 70 of the filter 11 is recovered (the recovery step of fig. 3). At this time, in a state where the circulation pump 116 is stopped, the second opening/closing device 20 is opened, and the cleaning opening/closing device 32 and the upstream opening/closing device 21 are closed, the recovery opening/closing device 90 of the recovery device 40 is opened, and the concentration pump 115 and the pump 18 are operated. At this time, the atmospheric air flows into the outlet side of the filtering membrane 70 of the filter 11 through the fourth line 15 to push out the residual filtered ascites toward the second line 13. The filtered ascites is concentrated by the second line 13 and the concentrator 110 and then received in the concentrated ascites bag 111.

When the gas flowing into the outlet side of the filtration membrane 70 of the filter 11 pushes out the filtered ascites on the outlet side of the filtration membrane 70 and reaches the gas detection device 91 on the second line 13, the gas is detected by the gas detection device 91. When gas is detected, the pump 18 and the concentration pump 115 are stopped, and the recovery opening/closing device 90 is closed.

Next, a cleaning step of the filtration membrane 70 is performed. As shown in fig. 5, the pump 18 is reversed in a state where the wash open/close device 32 and the first open/close device 19 are opened and the second open/close device 20 and the upstream open/close device 21 are closed. Thereby, the cleaning liquid in the cleaning liquid storage 30 flows into the second line 13 through the cleaning line 31, and flows into the outlet side of the filtration membrane 70 of the filter 11 through the second line 13. Then, the cleaning liquid flows out from the outlet side of the filtration membrane 70 to the inlet side of the filtration membrane 70 through the filtration membrane 70. At this time, the attached matter, which is attached to the filtration membrane 70 and causes clogging, is detached from the filtration membrane 70. The cleaning liquid flows out from the inlet side of the filter 11 to the third line 14 together with the deposits, and is discharged to the drain through the third line 14. The filter membrane 70 is cleaned in this manner (cleaning step of fig. 3). After a predetermined amount of cleaning liquid set in advance is supplied to the filter 11, the pump 18 is stopped, and the cleaning process of the filtration membrane 70 is completed.

When the step of cleaning the filtration membrane 70 is completed, as shown in fig. 1, the recovery opening/closing device 90 is closed, the circulation pump 116 is stopped, the first opening/closing device 19 and the cleaning opening/closing device 32 are closed, and the second opening/closing device 20 and the upstream opening/closing device 21 are opened, the pump 18 is rotated in the normal direction, the concentration pump 115 is operated, and the step of filtering and concentrating ascites is started again.

Each time the pressure difference (P1-P2) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the filter 11 exceeds a predetermined threshold value D, the process of filtering and concentrating ascites is stopped, and the process of recovering the filtered ascites and the process of cleaning the filtration membrane 70 are performed.

In the ascites filtering and concentrating step, the third pressure measuring device 117 and the fourth pressure measuring device 118 are operated to monitor the pressure on the inlet side and the pressure on the outlet side of the concentrating membrane 120 of the concentrator 110. For example, when the pressure difference (P3 to P4) between the pressure P3 on the inlet side and the pressure P4 on the outlet side of the concentration membrane 120 in the concentrator 110 exceeds a predetermined threshold value F, it is determined that the concentration membrane 120 is clogged, and the process of filtering and concentrating ascites is stopped.

According to the present embodiment, the ascites processing apparatus 1 includes the cleaning liquid storage section 30, the cleaning line 31, the cleaning opening/closing device 32, the first pressure measuring device 16, the second pressure measuring device 17, the first opening/closing device 19, the second opening/closing device 20, the upstream opening/closing device 21, the control device 50, and the like, and when the value (the pressure difference (P1-P2)) based on the pressure P2 measured by the second pressure measuring device 17 exceeds the predetermined threshold value D, the control device 50 reverses the pump 18 in a state where the cleaning opening/closing device 32 and the first opening/closing device 19 are opened and the second opening/closing device 20 and the upstream opening/closing device 21 are closed, and supplies the cleaning liquid in the cleaning liquid storage section 30 to the filtration membrane 70 through the cleaning line 31 and the second line 13. This makes it possible to accurately grasp the timing of cleaning the filtration membrane 70 and to automatically clean the filtration membrane 70.

Since the ascites treating apparatus 1 includes the recovery apparatus 40 for recovering the filtered ascites remaining on the outlet side of the filtering membrane 70 of the filter 11 through the second line 13, the filtered ascites remaining on the outlet side of the filtering membrane 70 of the filter 11 can be recovered before the cleaning of the filtering membrane 70 is started. Therefore, it is possible to prevent the filtered ascites from being wasted when the filtering membrane 70 is cleaned.

The recovery device 40 includes the fourth line 15 as a recovery line communicating with the outlet side of the filtration membrane 70 and the recovery opening/closing device 90 provided in the fourth line 15, and therefore can appropriately recover the filtered ascites remaining in the filter 11.

Since the fluid supplied to the outlet side of the filtration membrane 70 is a gas and the gas detection device 91 is provided in the second line 13, the filtered ascites can be easily recovered by using the gas. In addition, gas can be prevented from entering the downstream side of the second line 13, e.g., the concentrator 110, the concentrated ascites bag 111.

Since the filtration membrane 70 is a hollow fiber membrane, the inlet side of the filtration membrane 70 is the inside region of the hollow fiber membrane, and the outlet side of the filtration membrane 70 is the outside region of the hollow fiber membrane (internal pressure type filtration), ascites can be efficiently filtered by flowing out from the inside region to the outside region of the hollow fiber membrane.

Since the ascites treating apparatus 1 is provided with the concentrating system 60 for concentrating the filtered ascites in the second line 13, the filtration and concentration of the ascites can be appropriately performed.

Further, the concentration system 60 further includes a concentrated ascites bag 111 for storing the concentrated ascites, and a circulation line 114 for returning the concentrated ascites in the concentrated ascites bag 111 to the second line 13, so that the concentrated ascites can be re-concentrated to generate concentrated ascites at a desired concentration rate.

(second embodiment)

In the first embodiment, the inlet side of the filtration membrane 70 is the inside region of the hollow fiber membrane, and the outlet side of the filtration membrane 70 is the outside region of the hollow fiber membrane (internal pressure type filtration), but the outlet side of the filtration membrane may be the inside region of the hollow fiber membrane, and the inlet side of the filtration membrane may be the outside region of the hollow fiber membrane (external pressure type filtration). An example of this case will be described as a second embodiment.

Fig. 6 shows an outline of the structure of an ascites processing apparatus 1 in the second embodiment. In the ascites treatment apparatus 1, the outer region (inlet side) of the filtration membrane 70 of the filter 11 communicates with the fluid ports 11c and 11d, and the inner region (outlet side) of the filtration membrane 70 communicates with the fluid ports 11a and 11 b.

The downstream end of the first line 12 is connected to a liquid inlet 11d of the filter 11. The upstream end of the second line 13 is connected to the liquid inlet 11a of the filter 11. The third line 14 is connected to the liquid inlet 11c of the filter 11, and the fourth line 15 is connected to the liquid inlet 11b of the filter 11. The first pressure measuring device 16 is provided in the first line 12, and measures the pressure on the inlet side (outer region) of the filtration membrane 70 of the filter 11. The second pressure measuring device 17 is provided in the fourth line 15, and measures the pressure on the outlet side (inner region) of the filtration membrane 70 of the filter 11. The other configurations of the ascites treatment device 1 according to the second embodiment are the same as those of the first embodiment, and therefore the same reference numerals are used to omit the explanation.

In the ascites filtration and concentration step, the pump 18 is rotated in the normal direction and the concentration pump 115 is operated in a state where the collection shutter 90 is closed, the circulation pump 116 is stopped, the first shutter 19 and the cleaning shutter 32 are closed, and the second shutter 20 and the upstream shutter 21 are opened. The ascites in the abdominal water bag 10 flows into the inlet side of the filtration membrane 70, which is the outer region of the hollow fiber membrane, from the liquid inlet 11d of the filter 11, flows into the filtration membrane 70 from the outside to the inside, and is filtered. The filtered ascites having passed through the filter membrane 70 flows out from the fluid passage 11a to the second line 13 and is sent to the concentration system 60 to be concentrated. In the re-concentration step, the second opening/closing means 20 is closed, the circulation pump 116 is operated, the concentrated ascites in the concentrated ascites bag 111 is transferred to the concentrator 110 through the circulation line 114 and the second line 13, and the concentrated ascites is returned from the concentrator 110 to the concentrated ascites bag 111 through the concentration line 112 to be circulated. The concentrated ascites is then re-concentrated in this manner.

In the step of filtering and concentrating ascites, when the pressure difference (P1-P2) between the pressure P1 on the inlet side (outer region) of the filtration membrane 70 measured by the first pressure measuring device 16 and the pressure P2 on the outlet side (inner region) of the filtration membrane 70 measured by the second pressure measuring device 17 (value based on the pressure measured by the second pressure measuring device 17) exceeds the predetermined threshold value D, the step of recovering the filtered ascites and the step of cleaning the filtration membrane 70 are started.

In the recovery step of the filtered ascites, as shown in fig. 7, in a state where the circulation pump 116 is stopped, the first opening/closing device 19, the upstream opening/closing device 21, and the cleaning opening/closing device 32 are closed, and the second opening/closing device 20 is opened, the recovery opening/closing device 90 is opened, the pump 18 and the concentration pump 115 are operated, and the atmospheric air is caused to flow from the liquid passage port 11b of the filter 11 to the outlet side (inner side region) of the filter membrane 70 through the fourth line 15 to push out the remaining filtered ascites from the liquid passage port 11a to the second line 13. The filtered ascites extruded into the second line 13 is concentrated by the concentrator 110 and then received in the concentrated ascites bag 111.

When the gas flowing into the outlet side of the filtration membrane 70 of the filter 11 reaches the gas detection device 91 of the second line 13 and the gas detection device 91 detects the gas, the recovery opening/closing device 90 is closed and the pump 18 and the concentration pump 115 are stopped.

In the next cleaning step of the filtration membrane 70, as shown in fig. 8, the pump 18 is reversed with the recovery opening/closing device 90 closed, the cleaning opening/closing device 32 and the first opening/closing device 19 opened, and the second opening/closing device 20 and the upstream opening/closing device 21 closed. Thereby, the cleaning liquid in the cleaning liquid storage section 30 flows into the second line 13 through the cleaning line 31, and flows into the outlet side (inner region) of the filtration membrane 70 of the filter 11 through the second line 13. The cleaning liquid flows out from the outlet side of the filtration membrane 70 to the inlet side (outer region) of the filtration membrane 70 through the filtration membrane 70, is discharged to the third line 14 through the liquid inlet 11c of the filter 11, and is discharged to the liquid discharge portion through the third line 14. The filter membrane 70 is cleaned in this manner. When a predetermined amount of the cleaning liquid is supplied to the filter 11, the pump 18 is stopped, the cleaning opening/closing device 32 is closed, and the cleaning process of the filtration membrane 70 is completed.

When the cleaning step of the filtration membrane 70 is completed, the recovery opening/closing device 90 is closed, the circulation pump 116 is stopped, the first opening/closing device 19 is closed, and the second opening/closing device 20 and the upstream opening/closing device 21 are opened, the pump 18 is rotated in the normal direction, the concentration pump 115 is operated, and the filtration and concentration steps of ascites are started again.

According to the present embodiment, as in the first embodiment, the timing of cleaning the filtration membrane 70 can be accurately grasped, and the filtration membrane 70 can be automatically cleaned. Further, since the inlet side of the filtration membrane 70 is the outer region of the hollow fiber membrane and the outlet side of the filtration membrane 70 is the inner region of the hollow fiber membrane, the cleaning liquid can be flowed out from the inner region of the hollow fiber membrane to the outer region, and the filtration membrane 70 can be cleaned effectively.

(other modes of the first embodiment and the second embodiment)

In the first and second embodiments described above, as shown in fig. 9 and 10, when the cleaning step of the filtration membrane 70 is performed, the control device 50 may reverse the pump 18 in a state where the first opening/closing device 19, the second opening/closing device 20, the upstream opening/closing device 21, and the recovery opening/closing device 90 are closed, supply the cleaning liquid to the outlet side of the filtration membrane 70 to increase the pressure on the outlet side of the filtration membrane 70 to a pressure equal to or higher than the predetermined pressure B, and then open the first opening/closing device 19 to pass the cleaning liquid through the filtration membrane 70 (pulse cleaning). At this time, the pressure on the outlet side of the filtration membrane 70 is monitored by the second pressure measuring device 17, and when the pressure measured by the second pressure measuring device 17 becomes a pressure equal to or higher than a predetermined value B, the first opening/closing device 19 is opened. This makes it easy to peel off the substances adhering to the filter membrane 70 from the filter membrane 70, and the filter membrane 70 is effectively cleaned. The value B of the predetermined pressure on the outlet side of the filtration membrane 70 when the first opening/closing device 19 is opened is set to, for example, 200mmHg or more.

The controller 50 may repeat the operation (pulse cleaning) of causing the cleaning liquid to pass through the filtration membrane 70 after increasing the pressure on the outlet side of the filtration membrane 70 of the filter 11 to a pressure equal to or higher than the predetermined value B a plurality of times (pulse cleaning is repeated). At this time, after the first opening/closing means 19 is opened to allow the cleaning liquid to pass through the filtration membrane 70, the first opening/closing means 19 is closed and the pump 18 is reversed to supply the cleaning liquid in the cleaning liquid storage section 30 to the outlet side of the filtration membrane 70 through the cleaning line 31 and the second line 13, thereby increasing the pressure on the outlet side of the filtration membrane 70 to a pressure equal to or higher than the predetermined value B again. According to this example, the filter membrane 70 can be cleaned more effectively. The number of times of pulse cleaning is preferably one or more, for example.

After repeating the operation of increasing the pressure on the outlet side of the filtration membrane 70 of the filter 11 to a pressure equal to or higher than the predetermined value B a plurality of times and then passing the cleaning liquid through the filtration membrane 70 (repeating the pulse cleaning), the control device 50 supplies the cleaning liquid to the outlet side of the filtration membrane 70 by the pump 18 in a state where the cleaning opening/closing device 32 and the first opening/closing device 19 are opened and the second opening/closing device 20 and the upstream opening/closing device 21 are closed, and passes the cleaning liquid through the filtration membrane 70 without increasing the pressure on the outlet side of the filtration membrane 70 to a pressure equal to or higher than the predetermined pressure B (continuous cleaning), as shown in fig. 5 and 8. In this way, the attached matter peeled off from the filtration membrane 70 can be reliably discharged from the filter 11 without being retained in the filter 11. This continuous cleaning is preferably performed in an amount above the priming volume of the primary side of the filter 11, for example.

In the above embodiment, in the step of filtering and concentrating the ascites before the step of cleaning the filtration membrane 70, the control device 50 may decrease the flow rate of the normal rotation of the pump 18 and continue to supply the ascites to the filtration membrane 11 when the pressure difference (P1 to P2) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the first at least one filtration unit 11 exceeds the predetermined threshold value D, and may shift to the recovery step and the cleaning step when the pressure difference (P1 to P2) exceeds the threshold value D, and in the cleaning step, the cleaning liquid may be supplied to the filtration membrane 70 in a state where the pump 18 is reversely rotated, the second opening/closing device 20 and the upstream opening/closing device 21 are closed, and the first opening/closing device 19 and the cleaning opening/closing device 32 are opened. As shown in fig. 11, when the flow rate Q of the pump 18 is decreased, the pressure difference (P1-P2) of the filtration membrane 70 is temporarily decreased, and the load on the filtration membrane 70 is reduced. In this case, the execution of the cleaning step of the filtration membrane 70 can be delayed, and the number of times of the cleaning step and the total time taken for the cleaning step can be reduced. Thus, the ascites can be efficiently filtered and concentrated.

Further, the control device 50 may repeat deceleration of the pump 18 based on the pressure difference (P1-P2), and when the flow rate Q of the pump 18 reaches the predetermined minimum flow rate L and the pressure difference (P1-P2) exceeds the threshold value D, the control device may shift to the recovery step and the cleaning step in which the pump 18 is reversed to supply the cleaning liquid to the filtration membrane 70 in a state where the second opening/closing device 20 and the upstream opening/closing device 21 are closed and the first opening/closing device 19 and the cleaning opening/closing device 32 are opened. In this case, the total time can be reduced by further delaying the execution of the cleaning step, and the discharge of the useful substance can be suppressed to the minimum. In addition, as a method of minimizing the discharge of the useful substance, a minimum amount of ascites may be treated before stopping the normal rotation of the pump 18. In this case, it is possible to prevent the useful substances from being discharged due to excessive repetition of filtration and washing.

In the first and second embodiments, the circulation line 114 is connected to the second line 13 on the downstream side of the pump 18, but the circulation line 114 may be connected to the second line 13 on the upstream side of the pump 18, as shown in fig. 12, for example. A circulation line 114 is connected between the pump 18 and the filter 11. A circulation opening/closing device 130 is provided in the circulation line 114 instead of the circulation pump 116. The circulation opening/closing device 130 is, for example, an opening/closing valve. Further, an opening/closing device 131 is provided between the connection position of the circulation line 114 to the second line 13 and the filter 11. The opening/closing device 131 is, for example, an opening/closing valve.

In this case, for example, in the step of filtering and concentrating ascites, the circulation opening/closing device 130 is closed to prevent concentrated ascites in the concentrated ascites bag 111 from flowing into the circulation line 114, and the opening/closing device 131 and the second opening/closing device 20 are opened. In the re-concentration step, as shown in fig. 13, the circulation opening/closing device 130 and the second opening/closing device 20 are opened and the opening/closing device 131 is closed, and the concentrated ascites in the concentrated ascites bag 111 is circulated by passing the concentrated ascites through the circulation line 114, the second line 13, the concentrator 110, the concentrated line 112, and the concentrated ascites bag 111 in this order by the pump 18 and the concentration pump 115. In the cleaning step, as shown in fig. 14, the opening/closing device 131 and the cleaning opening/closing device 32 are opened, the circulation opening/closing device 130 is closed to prevent the cleaning liquid from flowing into the circulation line 114, and the second opening/closing device 20 is closed to prevent the cleaning liquid from flowing into the concentrator 110. According to this example, the circulation pump 116 is not required, and therefore the ascites treating apparatus 1 can be realized at low cost and with a simple structure.

In the first and second embodiments, the cleaning device has the cleaning opening/closing device 32, but may have a pump.

In the first and second embodiments, the purge line 31 is connected to the second line 13 downstream of the pump 18, but the purge line 31 may be connected to the second line 13 upstream of the pump 18. Examples of this case will be described as the third embodiment and the fourth embodiment.

(third embodiment)

The ascites treating apparatus 1 according to the third embodiment is different from the first embodiment in that the cleaning line 31 is connected to the second line 13 upstream of the pump 18, and the second opening/closing device 20 is not provided and a cleaning pump is provided. For example, as shown in fig. 15, the ascites treating apparatus 1 includes an ascites bag 10 as an ascites reservoir, a filter 11, a first line 12, a second line 13, a third line 14, a fourth line 15, a first pressure measuring device 16, a second pressure measuring device 17, a pump 18, a first opening/closing device 19, an upstream opening/closing device 21, a cleaning liquid reservoir 30, a cleaning line 31, a cleaning pump 33, a recovery device 40, a control device 50, a concentration system 60, and the like.

The filter 11 is an internal pressure filter type, as in the first embodiment, and the inner region of the filter membrane 70 communicates with the liquid inlet ports 11a and 11b, and the outer region of the filter membrane 70 communicates with the liquid inlet ports 11c and 11 d. The first line 12 is connected to the liquid inlet 11a of the filter 11, the second line 13 is connected to the liquid inlet 11c of the filter 11, the third line 14 is connected to the liquid inlet 11b of the filter 11, and the fourth line 15 is connected to the liquid inlet 11d of the filter 11.

The first pressure measuring device 16 is provided in the first line 12, and is capable of measuring the pressure on the primary side (inlet side) of the filtration membrane 70 of the filter 11. The second pressure measuring device 17 is provided in the fourth line 15, and is capable of measuring the pressure on the secondary side (outlet side) of the filtration membrane 70 of the filter 11.

A pump 18 is arranged in the second line 13. The pump 18 uses, for example, a tube pump for pressurizing ascites in a delivery tube by treating the tube.

The first opening/closing device 19 is, for example, an opening/closing valve, and is provided in the third line 14. The upstream opening/closing device 21 is, for example, an opening/closing valve, and is provided in the first line 12.

The cleaning line 31 connects the cleaning solution storage portion 30 with the second line 13. The purge line 31 is connected to the second line 13 at a position upstream of the pump 18 (on the filter 11 side), for example. The purge pump 33 is, for example, a tube pump, and is provided in the purge line 31. The cleaning liquid in the cleaning liquid storage section 30 can be supplied to the outlet side of the filtration membrane 70 through the cleaning line 31 and the second line 13 by the cleaning pump 33, and the filtration membrane 70 can be cleaned by passing the cleaning liquid through the filtration membrane 70. In the present embodiment, the cleaning pump 33, the cleaning line 31, and the cleaning reservoir 30 constitute a cleaning apparatus.

A gas detection device 91 is provided on the second line 13. The gas detection device 91 is provided upstream (on the filter 11 side) of the connection portion of the purge line 31.

The control device 50 is, for example, a microcomputer having a CPU, a memory, and the like. The control device 50 can control the operations of the respective devices such as the pump 18, the first opening/closing device 19, the upstream opening/closing device 21, the cleaning pump 33, the first pressure measurement device 16, the second pressure measurement device 17, the recovery opening/closing device 90 of the recovery device 40, the gas detection device 91, and the concentration system 60, and perform ascites treatment. The control device 50 can execute a program stored in advance in a memory, for example, to perform ascites treatment.

Specifically, for example, the control device 50 operates the cleaning pump 33 to supply the cleaning liquid in the cleaning liquid storage unit 30 to the filtration membrane 70 through the cleaning line 31 and the second line 13, while stopping the pump 18, opening the first opening/closing device 19, and closing the upstream opening/closing device 21, when the pressure difference exceeds a predetermined threshold value, based on the pressure difference between the pressure measured by the first pressure measuring device 16 and the pressure measured by the second pressure measuring device 17.

Since other configurations of the ascites processing apparatus 1 are the same as those of the first embodiment, the same reference numerals are used to omit descriptions.

Next, ascites treatment using the ascites treatment device 1 will be described.

First, as shown in fig. 15, the ascites bag 10 containing ascites fluid extracted from the patient is connected to the first line 12. Then, the ascites filtration and concentration step is started. The pump 18 and the concentration pump 115 are operated in a state where the first opening/closing device 19 is closed and the upstream opening/closing device 21 is opened. The recovery opening/closing device 90 of the cleaning pump 33 and the recovery device 40 is closed, and the circulation pump 116 is kept stopped.

Thereby, ascites in the ascites bag 10 is transported to the filter 11 through the first line 12. The ascites flows into the inlet side (inner region) of the filter membrane 70 from the fluid passage port 11a of the filter 11, and flows out to the outlet side (outer region) of the filter membrane 70 through the filter membrane 70. At this time, a predetermined causative substance is removed from the ascites. The filtered ascites flowing out to the outlet side of the filtering membrane 70 flows out from the filter 11 to the second line 13, is transferred to the concentrator 110 through the second line 13 and flows into the inlet side of the concentrating membrane 120 of the concentrator 110. Here, a part of the moisture of, for example, the filtered ascites flows out to the outlet side of the concentration membrane 120 through the concentration membrane 120 by the pressure difference (flow rate difference) between the pump 18 and the concentration pump 115. Thereby, water is removed from the filtrated ascites, and the filtrated ascites is concentrated. The concentrated ascites concentrated by the concentrator 110 is received in the concentrated ascites bag 111 through the concentration line 112. When a predetermined amount of concentrated ascites is stored in the concentrated ascites bag 111, the pump 18 is stopped, and the filtration and concentration steps are ended.

Subsequently, for example, a re-concentration step is performed. At this time, as shown in fig. 16, the circulation pump 116 and the concentration pump 115 are operated in a state where the pump 18 is stopped. Thereby, the concentrated ascites in the concentrated ascites bag 111 is transferred to the concentrator 110 through the circulation line 114 and the second line 13, and is returned from the concentrator 110 to the concentrated ascites bag 111 through the concentration line 112 to be circulated. The concentrated ascites is then concentrated to produce concentrated ascites of a desired concentration.

In the ascites filtering and concentrating step, the first pressure measuring device 16 and the second pressure measuring device 17 are operated to monitor the pressure on the inlet side and the pressure on the outlet side of the filtering membrane 70 of the filter 11. As shown in fig. 3, for example, when the pressure difference (P1-P2) (the pressure difference between membranes) (the value based on the pressure measured by the second pressure measuring device 17) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the filter 11 exceeds a predetermined threshold value D, the filtration membrane 70 is deemed to be clogged, the pump 18 is stopped, and the filtration and concentration steps of ascites are stopped. The threshold value D is obtained and set in advance by experiments and calculations.

Subsequently, for example, as shown in fig. 17, the filtered ascites remaining on the outlet side of the filtration membrane 70 of the filter 11 is recovered (the recovery step of fig. 3). At this time, in a state where the cleaning pump 33 and the circulation pump 116 are stopped and the first opening/closing device 19 and the upstream opening/closing device 21 are closed, the recovery opening/closing device 90 of the recovery device 40 is opened, and the pump 18 and the concentration pump 115 are operated. At this time, the atmospheric air flows into the outlet side of the filtering membrane 70 of the filter 11 through the fourth line 15 to push out the residual filtered ascites toward the second line 13. The filtered ascites is concentrated by the second line 13 and the concentrator 110 and then received in the concentrated ascites bag 111.

When the gas flowing into the outlet side of the filtering membrane 70 of the filter 11 pushes out the filtered ascites on the outlet side of the filtering membrane 70 and reaches the gas detecting means 91 of the second line 13, the gas is detected by the gas detecting means 91. When gas is detected, the recovery opening/closing device 90 is closed, and the pump 18 and the concentration pump 115 are stopped.

Next, a cleaning step of the filtration membrane 70 is performed. As shown in fig. 18, the cleaning pump 33 is operated in a state where the pump 18 is stopped, the upstream opening/closing device 21 and the recovery opening/closing device 90 are closed, and the first opening/closing device 19 is opened. Thereby, the cleaning liquid in the cleaning liquid storage 30 flows into the second line 13 through the cleaning line 31, and flows into the outlet side of the filtration membrane 70 of the filter 11 through the second line 13. Then, the cleaning liquid flows out from the outlet side of the filtration membrane 70 to the inlet side of the filtration membrane 70 through the filtration membrane 70. At this time, the attached matter, which is attached to the filtration membrane 70 and causes clogging, is detached from the filtration membrane 70. The cleaning liquid flows out from the inlet side of the filter 11 to the third line 14 together with the attached matter, and is discharged to the drain through the third line 14. The filter membrane 70 is cleaned in this manner (cleaning step of fig. 3). After a predetermined amount of cleaning liquid set in advance is supplied to the filter 11, the cleaning pump 33 is stopped, and the cleaning process of the filtration membrane 70 is completed.

When the step of cleaning the filtration membrane 70 is completed, as shown in fig. 15, the step of filtering and concentrating ascites is restarted by operating the pump 18 and the concentration pump 115 in a state where the cleaning pump 33 and the circulation pump 116 are stopped, the first opening/closing device 19 is closed, the upstream opening/closing device 21 is opened, and the recovery opening/closing device 90 is closed.

Each time the pressure difference (P1-P2) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the filter 11 exceeds a predetermined threshold value D, the process of filtering and concentrating ascites is stopped, and the process of recovering the filtered ascites and the process of cleaning the filtration membrane 70 are performed.

According to the present embodiment, the ascites processing apparatus 1 includes the pump 18, the cleaning liquid storage section 30, the cleaning line 31, the cleaning pump 33, the first pressure measuring device 16, the second pressure measuring device 17, the first opening/closing device 19, the upstream opening/closing device 21, the control device 50, and the like, and when the value (the pressure difference (P1-P2)) based on the pressure P2 measured by the second pressure measuring device 17 exceeds the predetermined threshold value D, the control device 50 operates the cleaning pump 33 in a state where the pump 18 is stopped, the upstream opening/closing device 21 is closed, and the first opening/closing device 19 is opened, to supply the cleaning liquid in the cleaning liquid storage section 30 to the filtration membrane 70 through the cleaning line 31 and the second line 13. This makes it possible to accurately grasp the timing of cleaning the filtration membrane 70 and to automatically clean the filtration membrane 70.

Since the filtration membrane 70 is a hollow fiber membrane, the inlet side of the filtration membrane 70 is the inside region of the hollow fiber membrane, and the outlet side of the filtration membrane 70 is the outside region of the hollow fiber membrane (internal pressure type filtration), ascites can be efficiently filtered by flowing out from the inside region to the outside region of the hollow fiber membrane.

(fourth embodiment)

In the third embodiment, the inlet side of the filtration membrane 70 is the inside region of the hollow fiber membrane, and the outlet side of the filtration membrane 70 is the outside region of the hollow fiber membrane (internal pressure type filtration), but the outlet side of the filtration membrane may be the inside region of the hollow fiber membrane, and the inlet side of the filtration membrane may be the outside region of the hollow fiber membrane (external pressure type filtration). An example of this case will be described as a fourth embodiment.

Fig. 19 shows an outline of the structure of an ascites treatment device 1 in the fourth embodiment. In the ascites treatment apparatus 1, the outer region (inlet side) of the filtration membrane 70 of the filter 11 communicates with the fluid ports 11c and 11d, and the inner region (outlet side) of the filtration membrane 70 communicates with the fluid ports 11a and 11 b.

The downstream end of the first line 12 is connected to a liquid inlet 11d of the filter 11. The upstream end of the second line 13 is connected to the liquid inlet 11a of the filter 11. The third line 14 is connected to the liquid inlet 11c of the filter 11, and the fourth line 15 is connected to the liquid inlet 11b of the filter 11. The first pressure measuring device 16 is provided in the first line 12, and measures the pressure on the inlet side (outer region) of the filtration membrane 70 of the filter 11. The second pressure measuring device 17 is provided in the fourth line 15, and measures the pressure on the outlet side (inner region) of the filtration membrane 70 of the filter 11. Since other configurations of the ascites treatment device 1 according to the fourth embodiment are the same as those of the third embodiment, the same reference numerals are used to omit descriptions.

In the ascites filtration and concentration step, the pump 18 and the concentration pump 115 are operated in a state where the cleaning pump 33 and the circulation pump 116 are stopped, the collection opening/closing device 90 and the first opening/closing device 19 are closed, and the upstream opening/closing device 21 is opened. The ascites in the abdominal water bag 10 flows into the inlet side of the filtration membrane 70, which is the outer region of the hollow fiber membrane, from the liquid inlet 11d of the filter 11, flows into the inside of the filtration membrane 70 from the outside, and is filtered. The filtered ascites having passed through the filter membrane 70 flows out from the fluid passage 11a to the second line 13 and is sent to the concentration system 60 to be concentrated. In the re-concentration step, the pump 18 is stopped, and the circulation pump 116 and the concentration pump 115 are operated, so that the concentrated ascites in the concentrated ascites bag 111 is transferred to the concentrator 110 through the circulation line 114 and the second line 13, and is returned from the concentrator 110 to the concentrated ascites bag 111 through the concentration line 112 to be circulated. The concentrated ascites is then re-concentrated in this manner.

In the step of filtering and concentrating ascites, when the pressure difference (P1-P2) between the pressure P1 on the inlet side (outer region) of the filtration membrane 70 measured by the first pressure measuring device 16 and the pressure P2 on the outlet side (inner region) of the filtration membrane 70 measured by the second pressure measuring device 17 (value based on the pressure measured by the second pressure measuring device 17) exceeds the predetermined threshold value D, the step of recovering the filtered ascites and the step of cleaning the filtration membrane 70 are started.

In the recovery step of the filtered ascites, as shown in fig. 20, in a state where the cleaning pump 33 and the circulation pump 116 are stopped and the first opening/closing device 19 and the upstream opening/closing device 21 are closed, the recovery opening/closing device 90 of the recovery device 40 is opened, the pump 18 and the concentration pump 115 are operated, and the atmospheric air is caused to flow from the liquid passage port 11b of the filter 11 to the outlet side (inner region) of the filtration membrane 70 through the fourth line 15 to push out the remaining filtered ascites from the liquid passage port 11a to the second line 13. The filtered ascites extruded into the second line 13 is concentrated by the concentrator 110 and then received in the concentrated ascites bag 111.

When the gas flowing into the outlet side of the filtration membrane 70 of the filter 11 reaches the gas detection device 91 on the second line 13 and the gas detection device 91 detects the gas, the recovery opening/closing device 90 is closed, and the pump 18 and the concentration pump 115 are stopped.

In the next cleaning step of the filtration membrane 70, as shown in fig. 21, the cleaning pump 33 is operated in a state where the pump 18 is stopped, the recovery opening/closing device 90 is closed, the first opening/closing device 19 is opened, and the upstream opening/closing device 21 is closed. Thereby, the cleaning liquid in the cleaning liquid storage 30 flows into the second line 13 through the cleaning line 31, and flows into the outlet side (inner region) of the filtration membrane 70 of the filter 11 through the second line 13. The cleaning liquid flows out from the outlet side of the filtration membrane 70 to the inlet side (outer region) of the filtration membrane 70 through the filtration membrane 70, is discharged to the third line 14 from the liquid inlet 11c of the filter 11, and is discharged to the liquid discharge portion through the third line 14. The filter membrane 70 is cleaned in this manner. When a predetermined amount of the cleaning liquid is supplied to the filter 11, the cleaning pump 33 is stopped, and the cleaning process of the filtration membrane 70 is completed.

When the step of cleaning the filtration membrane 70 is completed, the first opening/closing device 19 is closed, the upstream opening/closing device 21 is opened, and the pump 18 and the concentration pump 115 are operated to restart the step of filtering and concentrating ascites.

According to the present embodiment, as in the third embodiment, the timing of cleaning the filtration membrane 70 can be accurately grasped, and the filtration membrane 70 can be automatically cleaned. Further, since the inlet side of the filtration membrane 70 is the outer region of the hollow fiber membrane and the outlet side of the filtration membrane 70 is the inner region of the hollow fiber membrane, the cleaning liquid can be flowed out from the inner region of the hollow fiber membrane to the outer region, and the filtration membrane 70 can be cleaned effectively.

(other modes of the third embodiment and the fourth embodiment)

In the third and fourth embodiments described above, as shown in fig. 22 and 23, when the cleaning step of the filtration membrane 70 is performed, the control device 50 may supply the cleaning liquid to the outlet side of the filtration membrane 70 by the cleaning pump 33 in a state where the pump 18 is stopped and the first opening/closing device 19 and the upstream opening/closing device 21 are closed, to increase the pressure on the outlet side of the filtration membrane 70 to a pressure equal to or higher than a predetermined pressure, and then open the first opening/closing device 19 to allow the cleaning liquid to pass through the filtration membrane 70 (pulse cleaning). At this time, the pressure on the outlet side of the filtration membrane 70 is monitored by the second pressure measuring device 17, and when the pressure measured by the second pressure measuring device 17 becomes a pressure equal to or higher than a predetermined value B, the first opening/closing device 19 is opened. This makes it easy to peel off the substances adhering to the filter membrane 70 from the filter membrane 70, and the filter membrane 70 is effectively cleaned. The predetermined pressure value B on the outlet side of the filtration membrane 70 when the first opening/closing device 19 is opened is set to, for example, 200mmHg or more.

The controller 50 may repeat the operation (pulse cleaning) of causing the cleaning liquid to pass through the filtration membrane 70 after increasing the pressure on the outlet side of the filtration membrane 70 of the filter 11 to a pressure equal to or higher than the predetermined value B a plurality of times (pulse cleaning is repeated). At this time, after the first opening/closing means 19 is opened to allow the cleaning liquid to pass through the filtration membrane 70, the first opening/closing means 19 is closed, the cleaning liquid in the cleaning liquid storage section 30 is supplied to the outlet side of the filtration membrane 70 through the cleaning line 31 and the second line 13, and the pressure on the outlet side of the filtration membrane 70 is again increased to a pressure equal to or higher than the predetermined value B. According to this example, the filter membrane 70 can be cleaned more effectively. The number of times of pulse cleaning is preferably one or more, for example.

After repeating the operation of increasing the pressure on the outlet side of the filtration membrane 70 of the filter 11 to the predetermined value B or more and then passing the cleaning liquid through the filtration membrane 70 (repeating the pulse cleaning) a plurality of times, as shown in fig. 18 and 21, the control device 50 supplies the cleaning liquid to the outlet side of the filtration membrane 70 by the cleaning pump 33 in a state where the pump 18 is stopped, the first opening/closing device 19 is opened, and the upstream opening/closing device 21 is closed, and passes the cleaning liquid through the filtration membrane 70 without increasing the pressure on the outlet side of the filtration membrane 70 to the predetermined value B or more (continuous cleaning). In this way, the attached matter peeled off from the filtration membrane 70 can be reliably discharged from the filter 11 without being retained in the filter 11. This continuous cleaning is preferably performed in an amount above the priming volume of the primary side of the filter 11, for example.

In the above embodiment, in the step of filtering and concentrating the ascites before the step of cleaning the filtration membrane 70, the control device 50 may decrease the flow rate of the pump 18 and continue to supply the ascites to the filtration membrane 11 when the pressure difference (P1-P2) between the pressure P1 on the inlet side and the pressure P2 on the outlet side of the filtration membrane 70 in the first at least one filtration membrane 11 exceeds the predetermined threshold value D, and may shift to the recovery step and the cleaning step when the pressure difference (P1-P2) exceeds the threshold value D, and in the cleaning step, the cleaning liquid may be supplied to the filtration membrane 70 by the cleaning pump 33 in a state where the pump 18 is stopped, the first opening/closing device 19 is opened, and the upstream opening/closing device 21 is closed. As shown in fig. 11, when the flow rate Q of the pump 18 is decreased, the pressure difference (P1-P2) of the filtration membrane 70 is temporarily decreased, and the load on the filtration membrane 70 is reduced. Therefore, in this case, the execution of the cleaning step of the filtration membrane 70 can be delayed, and the number of times of the cleaning step and the total time taken for the cleaning step can be reduced. Thus, the ascites can be efficiently filtered and concentrated.

Further, the control device 50 may repeat deceleration of the pump 18 based on the pressure difference (P1-P2), and when the flow rate Q of the pump 18 reaches the predetermined minimum flow rate L and the pressure difference (P1-P2) exceeds the threshold value D, the control device may shift to the recovery step and the cleaning step in which the cleaning pump 33 is operated to supply the cleaning liquid to the filtration membrane 70 in a state where the pump 18 is stopped, the upstream opening/closing device 21 is closed, and the first opening/closing device 19 is opened. In this case, the total time can be reduced by further delaying the execution of the cleaning step, and the discharge of the useful substance can be suppressed to the minimum. In addition, as a method of minimizing the discharge of the useful substance, a minimum amount of ascites may be treated before stopping the normal rotation of the pump 18. In this case, it is possible to prevent the useful substances from being discharged due to excessive repetition of filtration and washing.

In the third and fourth embodiments, the circulation line 114 is connected to the second line 13 on the downstream side of the pump 18, but the circulation line 114 may be connected to the second line 13 on the upstream side of the pump 18 as shown in fig. 24, for example. The circulation line 114 is connected between the pump 18 and the connection position of the purge line 31. A circulation opening/closing device 140 is provided in the circulation line 114 instead of the circulation pump 116. The circulation opening/closing device 140 is, for example, an opening/closing valve.

In this case, for example, in the step of filtering and concentrating the ascites, the circulation opening/closing means 140 is closed so as to prevent the concentrated ascites in the concentrated ascites bag 111 from flowing into the circulation line 114. In the re-concentration step, as shown in fig. 25, the circulation opening/closing device 140 is opened, and the concentrated ascites in the concentrated ascites bag 111 is circulated by passing the concentrated ascites through the circulation line 114, the second line 13, the concentrator 110, the concentrated line 112, and the concentrated ascites bag 111 in this order by the pump 18 and the concentration pump 115. In the cleaning process, the circulation opening/closing device 140 is closed to prevent the cleaning liquid from flowing into the circulation line 114. According to this example, the circulation pump 116 is not required, and therefore the ascites treating apparatus 1 can be realized at low cost and with a simple structure.

In the third and fourth embodiments, the wash pump 33 is provided in the wash line 31, but the wash pump may be provided in the third line 14 and the wash opening/closing device 32 may be provided in the wash line 31.

(other modes of the first to fourth embodiments)

In the first to fourth embodiments described above, in the step of filtering and concentrating ascites, when the pressure difference (P1-P2) exceeds the threshold value D, the process proceeds to the collection step, but the process may proceed directly to the cleaning step without performing the collection step.

In the above embodiment, the re-concentration step is performed after the ascites filtration and concentration step is completed, but the re-concentration step may not be performed.

In the above embodiment, the cleaning step of the filtration membrane 70 is performed when the pressure difference (P1-P2) exceeds the predetermined threshold value D based on the pressure difference (P1-P2) between the pressure P1 measured by the first pressure measuring device 16 and the pressure P2 measured by the second pressure measuring device 17, but the cleaning step of the filtration membrane 70 may be performed when the pressure P2 exceeds the predetermined threshold value E based on the pressure P2 measured by the second pressure measuring device 17. In this case, the occurrence of clogging of the filter membrane 70 can be reliably detected. The threshold E is determined and set in advance by experiments and calculations.

In the first to fourth embodiments described above, the first pressure measurement device 16 may be provided in any one of the first line 12 and the third line 14. The second pressure measuring device 17 may be provided on any one of the second line 13 and the fourth line 15. For reference, the pressure P1 on the inlet side of the filter membrane 70 of the filter 11 may be estimated based on the atmospheric pressure or the pressure drop with respect to the abdominal water bag 10 without using the first pressure measuring device 16. The third line 14 is connected to the liquid inlet ports 11b and 11c of the filter 11, but may be connected to the first line 12 as shown in fig. 26 and 27, for example, as long as it communicates with the inlet side of the filter 11 and discharges the cleaning liquid having passed through the filtration membrane 70. At this time, the third line 14 is connected between the upstream opening/closing device 21 on the first line 12 and the filter 11. In this case, the cleaning liquid having passed through the filter membrane 70 is discharged to the liquid discharge portion through the first line 12 and the third line 14.

The recovery device 40 has a fourth line 15 opened to the atmosphere and a recovery opening/closing device 90 for opening and closing the fourth line 15, but may have another configuration. The recovery device 40 may have a fourth line 15 and a pump provided in the fourth line 15. In this case, by operating the pump on the fourth line 15, the atmospheric air flows into the fourth line 15 and is sent to the outlet side of the filtration membrane 70 of the filter 11 through the fourth line 15. The recovery apparatus 40 may further include a fluid supply device such as a pump for supplying a fluid to the outlet side of the filtration membrane 70 and extruding the filtered ascites on the outlet side of the filtration membrane 70 to the second line 13. Further, the ascites treating apparatus 1 does not necessarily need to be provided with the recovery apparatus 40.

The filter 11 need not be cylindrical and have four liquid communication ports, but may have other configurations. The filtration membrane 70 need not be a hollow fiber membrane, but may be another type of filtration membrane.

The configuration of the concentration system 60 is not limited to the configuration of the above embodiment. For example, the concentration pump 115 may be provided in the concentration line 112 or the drain line 113. A fourth pressure measurement device 118 may also be provided in the concentrate line 112. Either with or without the recycle line 114. The present invention can also be applied to an ascites treatment apparatus that does not include the concentration system 60. In this case, for example, the filtered ascites storage section may be connected to the second line 13, and the filtered ascites that has passed through the filter 11 may be stored in the filtered ascites storage section through the second line 13.

In the above embodiment, the ascites treatment apparatus 1 filters and concentrates the ascites in the ascites bag 10 and stores the filtered and concentrated ascites in the concentrated ascites bag 111, but the ascites may be directly taken out from the patient to the first line 12 and filtered and concentrated. In addition, the concentrated ascites after filtration and concentration can also be directly returned to the patient. Thus, the ascites treatment apparatus 1 may not include the ascites bag 10 or the concentrated ascites bag 111.

The above embodiment is an example in which the present invention is applied to an ascites treatment device 1 that treats ascites, but the present invention can also be applied to a body cavity fluid treatment device that treats other body cavity fluids such as pleural effusion.

Industrial applicability

The present invention is useful in providing a body cavity fluid treatment apparatus capable of accurately grasping the timing of cleaning a filter and automatically cleaning the filter.

Claims (20)

1. A body cavity fluid treatment device is characterized by comprising at least:

a filter having a filtering membrane, and filtering a body cavity liquid by passing the body cavity liquid through the filtering membrane;

a first line communicating with an inlet side of a filtering membrane of the filter for flowing a body cavity liquid through the filtering membrane;

a second line communicating with an outlet side of the filtration membrane of the filter, through which a filtrate volume having passed through the filtration membrane flows;

a cleaning device connected to the second line, and configured to supply a cleaning liquid to an outlet side of the filtration membrane through the second line, and to clean the filtration membrane by passing the cleaning liquid through the filtration membrane;

a pump that is provided on the upstream side of the second line from the position where the cleaning device is connected, and that sucks the body cavity liquid of the first line to the filter by normal rotation, and supplies the cleaning liquid of the cleaning device to the outlet side of the filtration membrane through the second line by reverse rotation and passes the cleaning liquid through the filtration membrane;

a pressure measuring device that measures a pressure on an outlet side of the filtration membrane of the filter;

a third line communicating with an inlet side of the filter and discharging the cleaning liquid having passed through the filtration membrane;

a first opening/closing device provided in the third pipeline;

a second opening/closing device provided on the second line downstream of a position connected to the cleaning device;

an upstream opening/closing device provided in the first pipeline; and

a control device that, when a value based on the pressure measured by the pressure measurement device exceeds a predetermined threshold value, reverses the pump in a state where the first opening/closing device is opened and the second opening/closing device and the upstream opening/closing device are closed, and supplies the cleaning liquid to the filtration membrane through the second line by the cleaning device,

the control device may decrease the flow rate of the forward rotation of the pump and continue to supply the body cavity liquid to the filter when the value based on the pressure exceeds the threshold value for at least the first time, and may reversely rotate the pump to supply the cleaning liquid to the filtration membrane when the value based on the pressure exceeds the threshold value after that, with the first opening/closing device opened and the second opening/closing device and the upstream opening/closing device closed.

2. The body cavity fluid treatment apparatus according to claim 1,

the cleaning device is provided with: a cleaning liquid storage part for storing a cleaning liquid; a cleaning line connecting the cleaning solution storage part and the second line; and a cleaning opening/closing device provided in the cleaning line.

3. The body cavity fluid treatment apparatus according to claim 1,

when the flow rate of the normal rotation of the pump reaches a predetermined minimum flow rate and the value based on the pressure exceeds the threshold value, the control device rotates the pump in the reverse direction to supply the cleaning liquid to the filtration membrane while opening the first opening/closing device and closing the second opening/closing device and the upstream opening/closing device.

4. A body cavity fluid treatment apparatus according to any one of claims 1 to 3,

the control device supplies the cleaning liquid to the outlet side of the filtration membrane by the pump in a state where the first opening/closing device, the second opening/closing device, and the upstream opening/closing device are closed, and raises the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than a predetermined pressure, and then opens the first opening/closing device to allow the cleaning liquid to pass through the filtration membrane.

5. The body cavity fluid treatment apparatus according to claim 4,

the control device repeats the following operations a plurality of times: the pressure on the outlet side of the filtration membrane of the filter is increased to a pressure not lower than a predetermined pressure, and then the cleaning liquid is passed through the filtration membrane.

6. The body cavity fluid treatment apparatus according to claim 5,

the control device is configured to repeat the operation of causing the cleaning liquid to pass through the filtration membrane after increasing the pressure on the outlet side of the filtration membrane of the filter to a pressure equal to or higher than a predetermined pressure a plurality of times, and then supply the cleaning liquid to the outlet side of the filtration membrane by the pump in a state where the first opening/closing device is opened and the second opening/closing device and the upstream opening/closing device are closed, and cause the cleaning liquid to pass through the filtration membrane without increasing the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than the predetermined pressure.

7. A body cavity fluid treatment device is characterized by comprising at least:

a filter having a filtering membrane, and filtering a body cavity liquid by passing the body cavity liquid through the filtering membrane;

a first line communicating with an inlet side of a filtering membrane of the filter for flowing a body cavity liquid through the filtering membrane;

a second line communicating with an outlet side of the filtration membrane of the filter, through which a filtrate volume having passed through the filtration membrane flows;

a pump disposed in the second line for drawing the body cavity fluid of the first line to the filter;

a cleaning device connected to the second line upstream of the pump, for supplying a cleaning liquid to the outlet side of the filtration membrane through the second line and cleaning the filtration membrane through the filtration membrane;

a pressure measuring device that measures a pressure on an outlet side of the filtration membrane of the filter;

a third line communicating with an inlet side of the filter and discharging the cleaning liquid having passed through the filtration membrane;

a first opening/closing device provided in the third pipeline;

an upstream opening/closing device provided in the first pipeline; and

a control device that supplies the cleaning liquid to the filtration membrane through the second line by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed, when a value based on the pressure measured by the pressure measurement device exceeds a predetermined threshold value,

the control device reduces the flow rate of the pump and continues to supply the body cavity liquid to the filter when the value based on the pressure exceeds the threshold value for at least the first time, and the control device supplies the cleaning liquid to the filtration membrane by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed when the value based on the pressure exceeds the threshold value thereafter.

8. The body cavity fluid treatment apparatus according to claim 7,

the cleaning device is provided with: a cleaning liquid storage part for storing a cleaning liquid; a cleaning line connecting the cleaning solution storage part and the second line; and a cleaning pump provided in the cleaning line for supplying the cleaning liquid.

9. The body cavity fluid treatment apparatus according to claim 7,

when the flow rate of the pump reaches a predetermined minimum flow rate and the value based on the pressure exceeds the threshold value, the control device supplies the cleaning liquid to the filtration membrane by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed.

10. The body cavity fluid treatment apparatus according to claim 8,

the control device supplies the cleaning liquid to the outlet side of the filtration membrane by the cleaning pump and increases the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than a predetermined pressure in a state where the pump is stopped and the first opening/closing device and the upstream opening/closing device are closed, and then opens the first opening/closing device to allow the cleaning liquid to pass through the filtration membrane.

11. The bodily cavity fluid processing device of claim 10,

the control device repeats the following operations a plurality of times: the pressure on the outlet side of the filtration membrane of the filter is increased to a pressure not lower than a predetermined pressure, and then the cleaning liquid is passed through the filtration membrane.

12. The body cavity fluid treatment apparatus according to claim 11,

the control device is configured to, after repeating the operation of causing the cleaning liquid to pass through the filtration membrane after increasing the pressure on the outlet side of the filtration membrane of the filter to a pressure equal to or higher than a predetermined pressure a plurality of times, supply the cleaning liquid to the outlet side of the filter by the cleaning device in a state where the pump is stopped, the first opening/closing device is opened, and the upstream opening/closing device is closed, and cause the cleaning liquid to pass through the filtration membrane without increasing the pressure on the outlet side of the filtration membrane to a pressure equal to or higher than the predetermined pressure.

13. The body cavity fluid treatment apparatus according to any one of claims 1 to 3 and 7 to 12,

the recovery device is further provided with a recovery device for recovering the filtrate cavity liquid remaining on the outlet side of the filtration membrane of the filter through the second line.

14. The bodily cavity fluid processing device of claim 13,

the recovery device includes a recovery line communicating with an outlet side of the filtration membrane, a recovery opening/closing device provided in the recovery line, and a fluid supply device for supplying a fluid to the recovery line.

15. The bodily cavity fluid processing device of claim 14,

the fluid is a gas and the fluid is,

a gas detection device is arranged on the second pipeline.

16. The body cavity fluid treatment apparatus according to any one of claims 1 to 3 and 7 to 12,

the filtration membrane is a hollow fiber membrane,

the inlet side of the filter membrane is the inner region of the hollow fiber membrane,

the outlet side of the filtration membrane is the outer region of the hollow fiber membrane.

17. The body cavity fluid treatment apparatus according to any one of claims 1 to 3 and 7 to 12,

the filtration membrane is a hollow fiber membrane,

the outlet side of the filtration membrane is the inner region of the hollow fiber membrane,

the inlet side of the filter membrane is the outer region of the hollow fiber membrane.

18. The body cavity fluid treatment apparatus according to any one of claims 1 to 3 and 7 to 12,

a concentration system is provided for concentrating the filtrate cavity liquid of the second line.

19. The bodily cavity fluid processing device of claim 18,

the concentration system has:

a concentrator for concentrating the filtered body fluid of the second line;

a concentration line through which a concentrated body fluid concentrated by the concentrator flows;

a drain line for draining the moisture removed by the concentrator; and

a concentration pump provided to the concentration line or the drain line.

20. The bodily cavity fluid processing device of claim 19,

the concentration system further has:

a concentrated body cavity liquid storage unit that stores the concentrated body cavity liquid; and

a circulation line for returning the concentrated body fluid in the concentrated body fluid storage to the second line.

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