JP2543466Y2 - Body fluid filtration and concentration device - Google Patents
Body fluid filtration and concentration deviceInfo
- Publication number
- JP2543466Y2 JP2543466Y2 JP1991028419U JP2841991U JP2543466Y2 JP 2543466 Y2 JP2543466 Y2 JP 2543466Y2 JP 1991028419 U JP1991028419 U JP 1991028419U JP 2841991 U JP2841991 U JP 2841991U JP 2543466 Y2 JP2543466 Y2 JP 2543466Y2
- Authority
- JP
- Japan
- Prior art keywords
- hollow fiber
- filter
- fiber membrane
- body fluid
- concentrator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【０００１】[0001]
【産業上の利用分野】この考案は、患者の腹水や胸水の
ような体液から有害物質を除去したのち濃縮し、患者の
体内へ戻すのに備える体液濾過濃縮装置に関するもので
ある。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device for filtering and concentrating bodily fluids for removing harmful substances from bodily fluids such as ascites and pleural effusion of a patient, concentrating the bodily fluids, and returning them to the patient's body.
【０００２】[0002]
【従来の技術】近年、肝ガン、肝硬変等に起因して患者
の腹腔内に貯留する腹水の治療法として、腹水を体外に
取り出し、腹水中にふくまれる癌細胞、細菌、血球等の
大分子量有害物質を除去し、有害物質を除去した腹水を
濃縮して、再び患者の血管に静注するといういわゆる腹
水濾過濃縮再静注治療が、腹水の貯留に伴う圧迫感の解
消、腹水中の有用成分の再利用という利点から、盛んに
行われてきており、種々の治療装置が提案され、利用さ
れている。その例として、患者から採取した腹水をまず
濾過したのち、濃縮して腹水回収容器に貯留する装置
（特公昭５５−１５２２１号参照）と、これとは逆に先
に腹水を濃縮したのち、濾過して腹水回収容器に貯留す
る装置（特公昭６１−１３８２３号公報参照）とがあ
る。2. Description of the Related Art In recent years , patients suffering from liver cancer, cirrhosis, etc.
As a treatment method for ascites stored in the abdominal cavity , ascites is taken out of the body, cancer cells contained in the ascites, bacteria, high molecular weight harmful substances such as blood cells are removed, and the ascites from which the harmful substances are removed is concentrated. the so-called belly called again to intravenous injection to the patient's blood vessel
Water filtration concentrated again intravenous therapy, eliminate the tightness due to ascites, from advantage reusing useful components in peritoneal fluid, which has been made to do Sheng, a variety of therapeutic devices have been proposed, it is used ing. As an example, after the filtration not a or ascites taken from a patient, the device for storing the ascites collection container and concentrated (see JP-B 55-15221), After concentration ascites forward to the contrary, there is a device for storing the ascites collection container (see JP-B-61-13823) and filtered filtration.
【０００３】[0003]
【考案が解決しようとする課題】ところが、上記いずれ
の装置でも、濾過工程では、腹水を中空糸膜の内側から
外側へ流して濾過しているので、大分子量の有害物質を
多量に含んだ腹水を濾過すると、中空糸膜の内面または
中空糸膜の内側空間に有害物質が付着堆積、または貯留
して、詰まりが発生し、濾過が困難になり、所望量の腹
水濾過ができなくなる。その結果、 流量を低下させ、
時間をかけて濾過する、 途中で濾過を中止する、また
は 途中で濾過器を交換する、などの対策を余儀なくさ
れている。[Problem to be solved by the invention]
In the filtration process, ascites is also collected from the inside of the hollow fiber membrane
As it flows outside and is filtered, high molecular weight harmful substances
Filtration of the ascites fluid contained in a large amount, the inner surface of the hollow fiber membrane or
Hazardous substances adhere and accumulate or accumulate in the space inside the hollow fiber membrane
Clogging occurs, filtering becomes difficult, and the desired amount of
Water filtration becomes impossible. as a result, Reduce the flow rate,
Filter over time, Stop filtering on the way, or
Is Replace the filter midway,And other measures
Have been.
【０００４】また、前者の装置では、腹水が連続して中
空糸型濾過器および中空糸型濃縮器の中空糸膜の内側を
流れ、中空糸膜内での圧力損失（流路抵抗）が大きくな
るので、迅速な処理を行うためにポンプを２台使用して
おり、装置が高価で、操作も複雑になっていた。他方、
後者の装置では、濃縮と濾過とを別々に行う、つまり非
連続的に行うので、処理時間がかかる。Further, in the former apparatus, ascites inside of the hollow fiber membrane of the hollow fiber-type filter and hollow fiber concentrator <br/> flow is continuous, the pressure loss in the hollow fiber membranes (flow Road resistance)
Runode, using two pumps for rapid processing
In addition , the equipment was expensive and the operation was complicated. On the other hand,
In the latter device, since the concentration and the filtration are performed separately, that is, discontinuously, the processing time is long.
【０００５】この考案は、上記問題点に鑑みてなされた
もので、多量の有害物質を含んだ腹水や胸水のような体
液の処理を行う場合であっても、多量の体液を、連続的
かつ短時間で濾過、濃縮することを可能にするととも
に、濾過器と濃縮器に適性な膜間圧力差を付加し、効率
よく体液の濾過、濃縮を行うことができる体液濾過濃縮
装置を提供するものである。[0005] This invention has been made in view of the above problems, even in the case of performing the processing of fluids, such as that plenty of containing harmful substances ascites and pleural effusion, a large amount of body fluid, continuous and filtered through a short, with it possible to concentrate, adding the suitability of transmembrane pressure difference filtration vessel and concentrator efficiently filtered fluid, liquid body Ru can be performed concentrating filtration concentrator Is provided.
【０００６】[0006]
【課題を解決するための手段】この考案に係る体液濾過
濃縮装置は、図１に示すように、体液を貯留する原体液
貯留容器１と、体液中の有害物質を除去する中空糸型の
濾過器２と、上記濾過器２から導出された濾過体液を濃
縮する濃縮器４と、上記濾過器２によって濾過された濾
過体液を上記濃縮器４に送り込むポンプ３と、上記濃縮
器４からの濃縮体液を濾過器２または濃縮器４へ戻すこ
となく回収する濃縮体液回収容器６と、上記濃縮器４と
濃縮体液回収容器６の間に設けられて、上記ポンプ３と
協働して濃縮器４の中空糸膜４５に膜間圧力差を付加す
る絞り弁５とを、チューブ（通路）Ｔで連結接続してお
り、１台のポンプ３によって上記濾過器２から濾過体液
を取り出し、上記濃縮器４に送り込んでいる。As shown in FIG. 1, a body fluid filtering and concentrating apparatus according to the present invention comprises a raw body fluid storage container 1 for storing body fluid, and a hollow fiber type filtration apparatus for removing harmful substances in body fluid. and vessel 2, a concentrator 4 for concentrating filtered body fluid derived from said filter 2, a pump 3 for feeding the filtered fluid that has been filtered by the filter 2 to the concentrator 4, the concentrated
Return the concentrated body fluid from the filter 4 to the filter 2 or the concentrator 4.
The concentrated bodily fluid collection container 6 to be collected
The pump is provided between the concentrated body fluid collection container 6 and the pump 3.
The membrane pressure difference is added to the hollow fiber membrane 45 of the concentrator 4 in cooperation.
A throttle valve 5 is connected and connected by a tube (passage) T, and a filter fluid is taken out from the filter 2 by one pump 3 and sent to the concentrator 4.
【０００７】濾過器２のハウジング２２の側壁に設けら
れた導入ポート２１には原体液貯留容器１が接続されて
いる。また濾過器２に内蔵された中空糸膜２５の内側空
間２６につながる一方の導出ポート２３にはポンプ３が
接続され、他方の導出ポート２４は閉塞されている。こ
のように濾過器２は、原体液貯留容器１から濾過器２へ
導入された体液が、中空糸膜２５の外側から内側へと透
過して濾過されるように構成されている。[0007] The introduction port 21 provided in the side wall of the Filtration vessel 2 of the housing 22 is connected to the original fluid reservoir 1
I have. The pump 3 is connected to one outlet port 23 leading to the interior space 26 of the hollow fiber membrane 25 incorporated in the filter 2, the other outlet port 24 is closed. This
Filter as 2, from the original fluid reservoir 1 into the filter 2
The introduced bodily fluid penetrates from the outside to the inside of the hollow fiber membrane 25.
It is configured to be filtered filtered.
【０００８】濃縮器４は、該濃縮器４に内蔵された中空
糸膜４５の内側空間４６につながる導入ポート４１に上
記ポンプ３が接続されており、また濃縮体液の導出ポー
ト４２にチューブ（通路）Ｔを介して濃縮体液回収容器
６が接続されている。このチューブＴには膜間圧力差付
加手段として絞り弁５が接続されている。一方、中空糸
膜４５の外側につながる排出ポート４３は大気開放され
ており、上記絞り弁５による通路の絞り作用によってチ
ューブＴ内の圧力を調整することにより、上記ポンプ３
と協働して中空糸膜４５の内側空間４６に正圧力をか
け、これによって、排出ポート４３（大気圧）との間、
つまり中空糸膜４５の内外間に圧力差を付加して、濃縮
器４での濃縮を円滑に行わせている。In the concentrator 4, the pump 3 is connected to an introduction port 41 connected to an inner space 46 of a hollow fiber membrane 45 built in the concentrator 4, and a tube (passage) is connected to a discharge port 42 for the concentrated body fluid. ) Concentrated body fluid collection container via T
6 are connected. This tube T has a transmembrane pressure difference
A throttle valve 5 is connected as an additional means. On the other hand, the exhaust port 43 leading to the outside of the hollow fiber membrane 45 is opened to the atmosphere, Ji by throttling the passage by the throttle valve 5
By adjusting the pressure in the tube T, the pump 3
The positive pressure is applied to the inner space 46 of the hollow fiber membrane 45 in cooperation with the outlet port 43 (atmospheric pressure).
That is, a pressure difference is applied between the inside and the outside of the hollow fiber membrane 45 so that the concentration in the concentrator 4 is performed smoothly.
【０００９】濾過器２に内蔵される中空糸膜２５として
は、体液中に含まれる有用物質、たとえばアルブミン、
グロブリン等の蛋白質は通過させるが、癌細胞、細菌、
血球のような有害物質（一般に大分子量）は通過させな
いものが使用される。このような中空糸膜２５として
は、例えば孔径０．２μｍのポリビニルアルコール（Ｐ
ＶＡ）系膜、ポリスルホン系膜等がある。[0009] filtration <br/> as a hollow fiber membrane 25 which is incorporated in the over-vessel 2, useful substances contained in body fluids, such as albumin,
Although proteins pass of globulin, cancer cells, bacteria,
Toxic substances (typically large molecular weight), such as blood cells that do not pass can be used. As such a hollow fiber membrane 25, for example , polyvinyl alcohol (P
VA) -based membranes and polysulfone-based membranes.
【００１０】また、濃縮器４に内蔵される中空糸膜４５
としては、濾過された体液中に含まれる過剰の水分を透
過させ、有用成分を含んだ体液を濃縮できるものが使用
される。このような中空糸膜４５としては、分画分子量
が約５００００の再生セルロース膜、エチレン−ビニル
アルコール系共重合体膜、ポリアクリロニトリル膜、セ
ルロース膜等がある。 Further, the hollow fiber membranes 45 built in the concentrator 4
The, by transmitting the excess of water contained in the filtered fluid, those capable of concentrating the fluid containing the useful components used
Is done . Examples of such a hollow fiber membrane 45 include a regenerated cellulose membrane having a molecular weight cut off of about 50,000, an ethylene-vinyl alcohol-based copolymer membrane, a polyacrylonitrile membrane, a cellulose membrane and the like.
【００１１】ポンプ３としては、体液を循環させる機能
を有し、かつ生体に無害なものであれば、特に制限なく
使用できるが、チューブＴをしごくことにより、その内
部の液体を圧送するタイプの市販の血液ポンプは、この
ような機能を備えており、好適である。[0011] The pump 3 has a function of circulating the fluid, and as long as it is harmless to a living body, without any particular limitation
Although it can be used , a commercially available blood pump of a type in which the liquid inside the tube T is pumped by squeezing the tube T has such a function and is suitable.
【００１２】[0012]
【００１３】[0013]
【作用】この考案の体液濾過濃縮装置では、ポンプ３を
回転させると、患者から採取された原体液貯留容器１内
の体液は、ポンプ３により吸引され、濾過器ハウジング
２２の側壁に設けられた導入ポート２１から濾過器ハウ
ジング２２に入り、濾過器２に内蔵された中空糸膜２５
の外側から内側へ透過することにより濾過されて中空糸
膜２５の内側空間２６に入り、導出ポート２３から導出
される。体液が中空糸膜２５を透過する際、その孔径よ
りも大きな大分子量の有害物質は中空糸膜２５を透過で
きず、中空糸膜２５の外表面または周辺に付着堆積し、
貯留される。この付着堆積物または貯留物が多くなる
と、濾過器２の詰まりが発生し、特に大分子量の有害物
質を多量に含む体液の濾過濃縮を行う場合には、この傾
向が強くなる。In the body fluid filtering and concentrating apparatus of the present invention, when the pump 3 is rotated, the body fluid in the original body fluid storage container 1 collected from the patient is sucked by the pump 3 and provided on the side wall of the filter housing 22. The hollow fiber membrane 25 built into the filter 2 enters the filter housing 22 through the introduction port 21.
Hollow fiber from the outside is filtered by excessive moisture into the interior of the
It enters the inner space 26 of the membrane 25 and is led out from the outlet port 23. When transparently medium Soraitomaku 25 body fluid, toxic substances large large molecular weight than the pore size can not over-permeable hollow fiber membrane 25, adhering deposited on the outer surface or periphery of the hollow fiber membrane 25,
Will be stored. If this adhering deposits or retentate increases, clogging of the filter 2 is generated, particularly in the case of performing the filtration enrichment of fluids containing a large amount of harmful substances in Oita molecular weight, this tendency becomes stronger.
【００１４】中空糸膜２５は、その形状からして、外表
面の面積が内表面の面積よりもかなり大きい。たとえ
ば、代表的な中空糸膜であるポリビニルアルコール中空
糸膜（内径３３０μｍ、外径５８０μｍ）の場合で、約
１．７倍である。また、濾過器２のハウジング２２内に
おける中空糸膜２５の外側に相当する部分の容積は、中
空糸膜２５の内部空間の全容積よりも大きい。この考案
の体液濾過濃縮装置では、中空糸膜２５の外側から内側
へと体液を透過させるので、大きな濾過面積を有する中
空糸膜２５の外側に有害物質を付着堆積させながら濾過
を行うこととなり、体液を中空糸膜の内側から外側へと
透過させる場合に比べて、付着堆積による詰まりが少な
くなる。また、上記のように濾過器２のハウジング２２
内にあっては、中空糸膜２５の外側に相当する部分の容
積が、中空糸膜２５の内部空間の全容積よりも大きいこ
とから、体液を中空糸膜の内側から外側へと透過させる
場合に比べて、上記貯留物の濃度がゆるやかに上昇する
ので、円滑な濾過が行われ、有害物質を多量に含んだ体
液を処理する場合であっても、詰まりが発生しにくく、
短時間に大量の体液を濾過濃縮することが可能である。Due to the shape of the hollow fiber membrane 25, the area of the outer surface is considerably larger than the area of the inner surface. For example, in the case of a polyvinyl alcohol hollow fiber membrane (inner diameter 330 μm, outer diameter 580 μm), which is a typical hollow fiber membrane, the ratio is about 1.7 times. Also, in the housing 22 of the filter 2
The volume of the portion corresponding to the outside of the hollow fiber membrane 25 is medium.
It is larger than the total volume of the internal space of the hollow fiber membrane 25 . This idea
Filtered through a biological fluid filtration concentrator, since the transmitting body fluid from the outside of the hollow fiber membrane 25 to the inside, while adhering and accumulating toxic substances in the outside of the hollow fiber membrane 25 having a large filtration area
Is performed, and the body fluid flows from the inside of the hollow fiber membrane to the outside.
Less clogging due to adhesion and deposition compared to transmission
It becomes . Further, as described above , the housing 22 of the filter 2 is
Inside, the volume of the portion corresponding to the outside of the hollow fiber membrane 25
Since the product is larger than the total volume of the internal space of the hollow fiber membrane 25 , the body fluid permeates from the inside to the outside of the hollow fiber membrane.
Compared with the case, the concentration of the stored material is gradually increased, so that smooth filtration is performed, even when treating a body fluid containing a large amount of harmful substances, hardly causes clogging,
It is possible to filter and concentrate a large amount of body fluid in a short time.
【００１５】また、上記のように中空糸膜２５の外側か
ら内側へと体液を透過させると、中空糸膜２５の狭くて
長い内側空間２６に体液を通して、中空糸膜２５の内側
から外側へと体液を透過させる場合と比較して、中空糸
膜２５を透過するときの圧力損失が少ないので、１台の
ポンプ３で充分迅速な濾過濃縮を行うことが可能とな
る。さらに、濾過器２による濾過と、濃縮器４による濃
縮とが連続的になされるので、濾過濃縮が一層迅速にな
される。 Further , as described above, the outside of the hollow fiber membrane 25
When the transmitting body fluids to Luo inward through body fluids to the long inner space 26 is narrow in the hollow fiber membrane 25, as compared with the case where the inside of the hollow fiber membrane 25 of body fluids causing transparently to the outside, the hollow fiber membranes 25 since the pressure loss at the time of excessive permeability of less, you are possible to perform sufficient rapid filtration concentrated in one pump 3
You . Further, filtration by the filter 2 and concentration by the concentrator 4
Since the reduction is performed continuously, the filtration and concentration become more rapid.
Is done.
【００１６】濾過器２によって濾過された体液は、ポン
プ３により、濃縮器４の導入ポート４１に送られ、中空
糸膜４５の内側空間４６を通過し、導出ポート４２から
導出され、絞り弁５を経由して濃縮体液回収容器６に送
られる。このとき、絞り弁５によって、中空糸膜４５に
膜間圧力差が付加され、中空糸膜４５の内側空間４６に
導入された体液から余剰の水分が分離されて中空糸膜４
５の外側に導出され、排出ポート４３より外部に排出さ
れる。このように、絞り弁５によって、中空糸膜４５の
内外間に大きな圧力差を付加することが可能となり、濃
縮処理を短時間に行うことができる。こうして、濃縮体
液回収容器６には、アルブミン等の有用成分が豊富とな
った濃縮体液が貯留される。The body fluid filtered by the filter 2 is sent to the inlet port 41 of the concentrator 4 by the pump 3, passes through the inner space 46 of the hollow fiber membrane 45, is led out of the outlet port 42, and is sent to the throttle valve 5. Is sent to the concentrated bodily fluid recovery container 6 via At this time, a transmembrane pressure difference is applied to the hollow fiber membrane 45 by the throttle valve 5, and excess moisture is separated from the body fluid introduced into the inner space 46 of the hollow fiber membrane 45, and the hollow fiber membrane 4 is removed.
5 and is discharged from the discharge port 43 to the outside. Thus, the throttle valve 5 allows the hollow fiber membrane 45
It is possible to add a large pressure difference between inside and outside,
Reduction processing can be performed in a short time. Thus, the concentrated body fluid collection container 6 stores the concentrated body fluid rich in useful components such as albumin.
【００１７】[0017]
【実施例】つぎに、この考案の実施例を説明する。 実施例１ 図２に示す装置を用いて腹水の濾過、濃縮を行った。濾
過器２は、ポリビニルアルコール中空糸膜２５（最大膜
孔径０．２μｍ、公称濾過面積０．６ｍ2 、中空糸内径
３３０μｍ、中空糸膜の厚さ１２５μｍ）を内蔵してお
り、濃縮器４は、再生セルロース中空糸膜４５（分画分
子量５００００、濾過面積２ｍ2 、中空糸膜内径１５０
μｍ、中空糸膜の厚さ８μｍ）を内蔵している。また、
各機器間を接続するチューブＴとしては、ポリ塩化ビニ
ル（ＰＶＣ）チューブを使用した。 Next, an embodiment of the present invention will be described. Example 1 Filtration and concentration of ascites fluid were performed using the apparatus shown in FIG. The filter 2 contains a polyvinyl alcohol hollow fiber membrane 25 (maximum membrane pore diameter 0.2 μm, nominal filtration area 0.6 m 2 , hollow fiber inner diameter 330 μm, hollow fiber membrane thickness 125 μm) .
The concentrator 4 comprises a regenerated cellulose hollow fiber membrane 45 (molecular weight cut off: 50,000, filtration area: 2 m 2 , hollow fiber membrane inner diameter: 150).
μm, and the thickness of the hollow fiber membrane is 8 μm) . Also,
The tube T connecting between the devices is made of polyvinyl chloride.
(PVC) tube was used.
【００１８】濾過工程に対しては、濾過器２の一方（下
側）の導出ポート２３とポンプ３との間にチャンバ７を
設け、差圧計９を用いて、上記チャンバ７の上部空間７
１と、濾過器ハウジング２２の側壁に設けたもう一つの
ポート２７との間の圧力差、すなわち、中空糸膜２５の
膜間圧力差を測定した。For the filtration step, a chamber 7 is provided between the outlet port 23 on one side (lower side) of the filter 2 and the pump 3, and a differential pressure gauge 9 is used to form an upper space 7 of the chamber 7.
1 and another port 27 provided on the side wall of the filter housing 22, that is , the transmembrane pressure difference of the hollow fiber membrane 25 was measured.
【００１９】また、濾過器２の他方（上側）の導出ポー
ト２４とチャンバ７とをチューブＴで連結し、一方の導
出ポート２３側のチューブＴが詰まったときに、切替え
が可能なように設定している。すなわち、導出ポート２
４側のチューブＴは、通常、ピンチ弁１１などで閉止し
ておき、導出ポート２３側のチューブＴが詰まったとき
に、上記ピンチ弁１１を取り外すことにより、導出ポー
ト２４とチャンバ７を連通させるとともに、導出ポート
２３側のチューブＴを破線で示すようにピンチ弁１１Ａ
で閉止する。これにより、一方の導出ポート２３側のチ
ューブＴが詰まったときでも上記濾過器２からの導出経
路を切り替えて、濾過を継続して行うことができる。Further, the other (upper) outlet port 24 of the filter 2 and the chamber 7 are connected by a tube T, so that when the tube T on one outlet port 23 is clogged, switching can be performed. doing. In other words, the guide out port 2
The tube T on the fourth side is usually closed with a pinch valve 11 or the like.
Advance, when the tube T guide exit port 23 side is clogged, by removing the pinch valve 11, guide out Rutotomoni communicates the port 24 and the chamber 7, a tube T of the outlet port 23 side by dashed line Pi Nchiben 11A as shown
Close with. As a result, the switch on the one outlet port 23 side is
Even when the cube T is jammed switches the derived path from the filter 2 can be performed continuously filtered.
【００２０】さらに、ポンプ３と濃縮器４の間にはもう
一つのチャンバ８を設けて、これに圧力計１０を接続
し、絞り弁からなる膜間圧力差付加手段５で付加される
圧力を測定した。本考案の体液濾過濃縮装置を運転する
前には、生理食塩水で濾過器２、濃縮器４および接続チ
ューブＴ内を洗浄し、これら濾過器２、濃縮器４および
接続チューブＴ内に、この生理食塩水を充填した。Further, another chamber 8 is provided between the pump 3 and the concentrator 4, and a pressure gauge 10 is connected to the chamber 8, and the pressure applied by the transmembrane pressure difference applying means 5 comprising a throttle valve is controlled. It was measured. Before <br/> operating the biological fluid filtration concentrating apparatus of the present invention, the filter 2 with saline, wash the concentrator 4 and the connecting tube T, these filter 2, concentrator 4 and
This physiological saline was filled in the connection tube T.
【００２１】ポンプ３を作動させて、流量５０ミリリッ
トル／分の速度で、患者より採取されて原体液貯留容器
１に貯留された腹水２．５リットル（総蛋白濃度４．９
グラム／デシリットル）の濾過濃縮を開始し、約５０分
で、６００ミリリットルの濾過濃縮腹水（総蛋白濃度
９．５グラム／デシリットル）を濃縮体液回収容器６に
回収することができた。濾過器２の詰まりを示す差圧計
９の指示は、開始直後は０mmHgであり、その後ゆるやか
に上昇したが、最大で１５０mmHgであった。[0021] activates the pump 3, at flow rate of 50 ml / min, the original fluid reservoir is collected from a patient
2.5 liters of ascites stored in 1 (total protein concentration 4.9)
(G / dL) was started, and in about 50 minutes, 600 ml of the filtered and concentrated ascites (total protein concentration: 9.5 g / dL) could be collected in the concentrated bodily fluid collection container 6 . Instruction differential pressure gauge 9 showing the clogging of Filtration vessel 2, immediately after the start is 0 mmHg, was then slowly increased, was 150mmHg at maximum.
【００２２】本実施例では、膜間圧力差付加手段５とし
て絞り弁を用いており、チャンバ８に設けた圧力計１０
を見ながら絞り弁５を調整することにより、容易に膜間
圧力差を制御できる。なお、濃縮体液回収容器６に回収
された腹水は、点滴により、患者の血管に静注した。In this embodiment, a throttle valve is used as the transmembrane pressure difference applying means 5, and a pressure gauge 10 provided in the chamber 8 is used.
By adjusting the throttle valve 5 while watching the pressure, the transmembrane pressure difference can be easily controlled. The ascites collected in the concentrated body fluid collection container 6 was intravenously injected into a patient's blood vessel by infusion.
【００２３】比較例１ 図３に示す装置を用いて腹水の濾過、濃縮を行った。こ
の図３の装置は、濾過工程のみについて、濾過器２に内
蔵された中空糸膜２５の内側から外側へ腹水が透過する
ようにチューブの接続を変更し、かつ膜間圧力差測定用
のチャンバー７を原体液貯留容器１と濾過器２の間に設
けたこと以外は、図２の装置と同一である。つまり、原
体液貯留容器１に接続されたチャンバー７の出口を、濾
過器２の中空糸膜２５の内側空間２６につながる一方の
ポート２８Ａに接続し、他方のポート２８Ｂを閉塞し、
中空糸膜２５の外側につながるポート２９をポンプ３に
接続した。濾過濃縮は、実施例１と同一の患者から同一
時期に採取した２．５リットルの腹水を使用して行っ
た。その結果、約１．５リットルの腹水が濾過器２を通
過した時点で、差圧計９が１５０mmHgを振り切れたの
で、以降、ポンプ３の流量を徐々に低下させて運転を継
続し、約２時間後にようやく６００ミリリットルの濃縮
腹水を濃縮体液回収容器６に回収することができた。Comparative Example 1 Filtration and concentration of ascites were performed using the apparatus shown in FIG. The apparatus shown in FIG. 3 is provided inside the filter 2 only for the filtration step .
Change the built been from the inside of the hollow fiber membranes 25 of the tube as ascites outward to over-permeable connection, and provided with a chamber 7 of the transmembrane pressure difference measurement between the original fluid reservoir 1 filter 2 Except for this, it is the same as the apparatus of FIG. That is, the outlet of the chamber 7 connected to the bulk fluid storage container 1 is connected to one port 28A connected to the inner space 26 of the hollow fiber membrane 25 of the filter 2, and the other port 28B is closed.
The port 29 connected to the outside of the hollow fiber membrane 25 was connected to the pump 3. Filtration and concentration were performed using 2.5 liters of ascites collected at the same time from the same patient as in Example 1. As a result, when about 1.5 liters of ascites passed through the filter 2, the differential pressure gauge 9 exceeded 150 mmHg. Thereafter, the flow rate of the pump 3 was gradually decreased, and the operation was continued for about 2 hours. Only 600 ml of the concentrated ascites could be finally collected in the concentrated bodily fluid collection container 6 later.
【００２４】[0024]
【考案の効果】以上説明したように、この考案によれ
ば、濾過器２に内蔵された中空糸膜２５の外側から内側
へと体液を透過させて濾過を行うので、有害物質を多量
に含んだ体液を処理する場合であっても、濾過器２の詰
まりが少なく、短時間に大量の体液の濾過濃縮を行うこ
とができる。また、濃縮器４の中空糸膜４５に大きな膜
間圧力差を付加することにより、濃縮処理を短時間に行
うことができる。さらに、中空糸膜２５内での圧力損失
が少なくなるので、１台のポンプ３で体液の濾過濃縮が
可能となり、したがって体液濾過濃縮装置の構造が簡単
になる。As described above, according to the present invention, since the bodily fluid is permeated and filtered from the outside to the inside of the hollow fiber membrane 25 incorporated in the filter 2, a large amount of harmful substances is contained. Even when treating body fluid, the filter 2 is less clogged, and a large amount of body fluid can be filtered and concentrated in a short time. The hollow fiber membrane 45 of the concentrator 4 has a large membrane.
Enrichment process in a short time
I can. Further , since the pressure loss in the hollow fiber membrane 25 is reduced, the filtration and concentration of the bodily fluid can be performed by one pump 3, and thus the structure of the bodily fluid filtration and concentration device is simplified.
【図１】本考案の体液濾過濃縮装置の構成を示す系統図
である。FIG. 1 is a system diagram showing a configuration of a body fluid filtration and concentration device of the present invention.
【図２】本考案の体液濾過濃縮装置の一実施例を示す系
統図である。FIG. 2 is a system diagram showing an embodiment of the body fluid filtration and concentration device of the present invention.
【図３】比較例を示す系統図である。FIG. 3 is a system diagram showing a comparative example.
１…原体液貯留容器、２…濾過器、３…ポンプ、４…濃
縮器、５…絞り弁（膜間圧力差付加手段）、６…濃縮体
液回収容器、２５，４５…中空糸膜、Ｔ…通路。DESCRIPTION OF SYMBOLS 1 ... Concentrate liquid storage container, 2 ... Filter, 3 ... Pump, 4 ... Concentrator, 5 ... Throttle valve (means for adding pressure difference between membranes) , 6 ... Concentrated body fluid recovery container, 25, 45 ... Hollow fiber membrane , T ... passages .
Claims (1)
空糸膜２５を内蔵し体液中の有害物質を除去する濾過器
２と、中空糸膜４５を内蔵し上記濾過器２から導出され
た濾過体液を濃縮する濃縮器４と、上記濾過器２によっ
て濾過された濾過体液を上記濃縮器４に送り込むポンプ
３と、上記濃縮器４からの濃縮体液を濾過器２または濃
縮器４へ戻すことなく回収する濃縮体液回収容器６と、
上記濃縮器４と濃縮体液回収容器６の間の通路Ｔに設け
られて、この通路Ｔ内の圧力を調整する事により、上記
ポンプ３と協働して濃縮器４の中空糸膜４５に膜間圧力
差を付加する絞り弁５とを備え、 上記濾過器２は、中空糸膜２５の外側から内側へ体液が
透過するように構成されていることを特徴とする体液濾
過濃縮装置。1. A body fluid storage container 1 for storing a body fluid, a filter 2 containing a hollow fiber membrane 25 for removing harmful substances in the body fluid, and a filter 2 containing a hollow fiber membrane 45 and derived from the filter 2. A concentrator 4 for concentrating the filtered body fluid, a pump 3 for feeding the filtered body fluid filtered by the filter 2 to the concentrator 4, and a condensate body fluid from the concentrator 4 to the filter 2 or the concentrator.
A concentrated bodily fluid collection container 6 for collecting without returning to the contractor 4,
Provided in a passage T between the concentrator 4 and the concentrated bodily fluid recovery container 6
Is, by adjusting the pressure in the passage T, and a throttle valve 5 for adding the intermembrane pressure differential in the hollow fiber membrane 45 of the concentrator 4 in cooperation with the pump 3, the filter 2 Is a device for filtering and concentrating bodily fluids, characterized in that bodily fluids are transmitted from the outside to the inside of the hollow fiber membrane 25.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1991028419U JP2543466Y2 (en) | 1991-03-29 | 1991-03-29 | Body fluid filtration and concentration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1991028419U JP2543466Y2 (en) | 1991-03-29 | 1991-03-29 | Body fluid filtration and concentration device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04117646U JPH04117646U (en) | 1992-10-21 |
| JP2543466Y2 true JP2543466Y2 (en) | 1997-08-06 |
Family
ID=31912522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1991028419U Expired - Lifetime JP2543466Y2 (en) | 1991-03-29 | 1991-03-29 | Body fluid filtration and concentration device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2543466Y2 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6397781B2 (en) * | 2015-02-26 | 2018-09-26 | 旭化成メディカル株式会社 | Concentrator |
| JP6913994B2 (en) * | 2017-07-07 | 2021-08-04 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| JP6532913B2 (en) * | 2017-07-07 | 2019-06-19 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| JP6912515B2 (en) * | 2017-07-07 | 2021-08-04 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| JP6501421B2 (en) * | 2017-07-07 | 2019-04-17 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| JP6667852B2 (en) * | 2018-08-18 | 2020-03-18 | 国立大学法人徳島大学 | Stock solution processing device and method of operating stock solution processing device |
| JP7096411B2 (en) * | 2019-03-18 | 2022-07-05 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| JP7096410B2 (en) * | 2019-05-22 | 2022-07-05 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| JP7057977B2 (en) * | 2019-08-02 | 2022-04-21 | 国立大学法人徳島大学 | Undiluted solution processing equipment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6083665A (en) * | 1983-10-17 | 1985-05-11 | 旭メデイカル株式会社 | Abdominal water treating apparatus |
| JPS6084110A (en) * | 1983-10-17 | 1985-05-13 | Asahi Medical Kk | Composite type filtering concentrator |
-
1991
- 1991-03-29 JP JP1991028419U patent/JP2543466Y2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04117646U (en) | 1992-10-21 |
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