JP6762772B2 - Blood purification device and its connection confirmation method - Google Patents

Description

The present invention relates to a blood purification device for performing blood purification treatment with a blood purification device connected to a blood circuit, and a method for confirming the connection thereof.

The blood circuit of a blood purifier is usually configured to allow the patient's blood to circulate extracorporeally after being filled with a priming solution by priming. Recent blood purification devices have been proposed to perform a connection confirmation step for confirming whether or not the blood circuit connection is normally performed when priming is performed (for example, Patent Document 1, Patent Document 1, 2). In the conventional connection confirmation process, a fluid replacement pump, a compound pump, or the like is driven to pressurize the inside of the blood circuit, and whether or not the pressure exceeds a predetermined value by the pressure detecting means provided in the blood circuit is further determined. Was performed by determining whether or not the pressure value was maintained for a certain period of time even after the pressurization was stopped.

Japanese Unexamined Patent Publication No. 2011-161060 Japanese Unexamined Patent Publication No. 2012-192101

However, in the above-mentioned conventional blood purification device, if there is an unconnected part close to the atmosphere, the connection failure can be easily determined, but in order to determine the connection failure caused by a slight loosening of the connection part. Needs to be pressurized to a higher pressure, or to monitor whether a constant pressure is held for a longer period of time. Therefore, there is a problem that it is necessary to extend the time for the connection confirmation process in order to perform the connection confirmation with higher accuracy.

The present invention has been made in view of such circumstances, and is a blood purification device capable of performing a connection confirmation step for confirming the quality of a blood circuit connection in a shorter time and with high accuracy, and a connection confirmation thereof. To provide a method.

The invention according to claim 1 is connected between a blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating a patient's blood, and the arterial blood circuit and the venous blood circuit. A blood purification means for purifying blood flowing through the circuit, a first bubble detecting means and a second bubble detecting means capable of detecting bubbles in the liquid flowing in the blood circuit, and a priming liquid for the blood circuit. The control means is provided in a blood purification apparatus provided with a control means capable of performing a connection confirmation step for confirming the quality of the connection of the blood circuit as well as performing priming of the blood circuit. On the condition that the tip of the arterial blood circuit and the tip of the venous blood circuit are connected and the priming solution is filled in the blood circuit, a negative pressure is applied to the blood circuit and the air bubbles are applied. The detection means is configured to determine whether or not a bubble is detected and perform the connection confirmation step, and the control means is the first of the first bubble detecting means and the second bubble detecting means. The connection failure location is identified based on the detected bubble detecting means , and the control means drives a blood pump arranged in the arterial blood circuit while closing a predetermined position of the blood circuit. It is characterized in that the negative pressure can be applied to the blood circuit .

According to a second aspect of the present invention, in the blood purification apparatus according to the first aspect, the bubble detecting means may be arranged in a plurality of blood circuits to detect bubbles at a plurality of locations, and the control means may contain bubbles. It is characterized in that a poor connection location can be identified according to the detected bubble detecting means.

The invention according to claim 3 is the blood purification apparatus according to claim 1 or 2 , wherein the control means is a priming liquid filling step for filling the blood circuit with a priming liquid and a priming liquid filling step. It is characterized in that the circulation washing step of circulating the filled priming liquid in the blood circuit can be sequentially performed, and the connection confirmation step is performed at the time of the circulation washing step.

The invention according to claim 4 is connected between a blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating a patient's blood, and the arterial blood circuit and the venous blood circuit. A blood purification means for purifying blood flowing through the circuit, a first bubble detecting means and a second bubble detecting means capable of detecting bubbles in the liquid flowing in the blood circuit, and a priming liquid for the blood circuit. In the connection confirmation method of the blood purification device provided with a control means capable of performing the priming of the blood circuit and performing the connection confirmation step for confirming the connection quality of the blood circuit. On condition that the tip of the blood circuit on the arterial side and the tip of the blood circuit on the venous side are connected and the priming solution is filled in the blood circuit, a negative pressure is applied to the blood circuit and the bubble is detected. It is determined whether or not bubbles are detected by the means, a blood circuit connection confirmation step is performed, and the connection is made based on the bubble detecting means detected earlier among the first bubble detecting means and the second bubble detecting means. It is characterized in that a negative pressure is applied to the blood circuit by identifying a defective portion and driving a blood pump arranged in the blood circuit on the arterial side while closing a predetermined position of the blood circuit. To do.

The invention according to claim 5 is the method for confirming the connection of the blood purification device according to claim 4 , wherein a plurality of the bubble detecting means are arranged in the blood circuit and can detect bubbles at a plurality of places, and the bubbles are detected. It is characterized in that a poor connection location can be identified according to the bubble detecting means.

The invention according to claim 6 is the method for confirming the connection of the blood purification device according to claim 4 or 5 , wherein the priming liquid is filled in the blood circuit and the priming liquid is filled. It is characterized in that the circulation washing step of circulating the priming liquid in the blood circuit can be sequentially performed, and the connection confirmation step is performed at the time of the circulation washing step.

According to the first and fourth aspects of the invention, on condition that the blood circuit is filled with the priming solution, a negative pressure is applied to the blood circuit and whether or not bubbles are detected by the bubble detecting means. Since the blood circuit connection confirmation step is performed by determining the above, the connection confirmation step for confirming the quality of the blood circuit connection can be performed in a shorter time and with high accuracy.
Further, since a negative pressure can be applied to the blood circuit by driving the blood pump arranged in the arterial blood circuit while blocking the predetermined position of the blood circuit, the connection can be made during or after the priming of the blood circuit. The confirmation process can be easily performed.

According to the inventions of claims 2 and 5, a plurality of bubble detecting means are arranged in the blood circuit and can detect bubbles at a plurality of locations, and at the same time, a poorly connected portion is determined according to the bubble detecting means in which the bubbles are detected. Since it can be identified, it is possible to take measures more quickly and smoothly after the connection failure is confirmed.

According to the inventions of claims 3 and 6 , a priming liquid filling step of filling the blood circuit with the priming liquid and a circulation washing step of circulating the priming liquid filled in the priming liquid filling step in the blood circuit are performed. Since the connection confirmation step can be performed sequentially at the time of the circulation cleaning step, the connection confirmation step can be satisfactorily performed in the circulation cleaning step of the priming process of the blood circuit.

Schematic diagram showing a hemodialysis apparatus (blood purification apparatus) according to the first embodiment of the present invention. Flow chart showing the control contents at the time of connection confirmation in the hemodialysis machine Schematic diagram showing the state when the connection of the blood circuit in the hemodialysis machine is confirmed (when the connection is confirmed by pressurization). Schematic diagram showing the state of the blood circuit during priming (overflow step: filling step) in the hemodialysis machine. Schematic diagram showing the state of the blood circuit during priming (liquid feeding process: filling process) in the hemodialysis machine. Schematic diagram showing the state of the circulation washing process of the blood circuit in the hemodialysis machine Schematic diagram showing the state of the blood circuit in the hemodialysis machine during the washing process Schematic diagram showing a hemodialysis apparatus (blood purification apparatus) according to a second embodiment of the present invention. Flow chart showing the control contents at the time of connection confirmation in the hemodialysis machine Schematic diagram showing the state of the circulation washing process of the blood circuit in the hemodialysis machine A flowchart showing the control contents at the time of connection confirmation in the hemodialysis apparatus (blood purification apparatus) according to the third embodiment of the present invention. Schematic diagram showing the state of the hemodialysis machine when negative pressure is applied Schematic diagram showing the state of the circulation washing process of the blood circuit in the hemodialysis machine A flowchart showing the control contents at the time of connection confirmation in the hemodialysis apparatus (blood purification apparatus) according to the fourth embodiment of the present invention. Schematic diagram showing the state when the connection of the blood circuit in the hemodialysis machine is confirmed (when the connection is confirmed by pressurization). Schematic diagram showing the state of the blood circuit in the hemodialysis apparatus at the time of priming (the step of filling the priming liquid with the priming liquid supply line) Schematic diagram showing a state at the time of priming the blood circuit in the hemodialysis machine (step of filling the blood circuit with the priming solution) and a state at the time of priming the blood circuit in the hemodialysis machine (circulation washing step). Schematic diagram showing the state of the blood circuit during priming (gas purging step) in the hemodialysis machine. Schematic diagram showing the state when negative pressure is applied in the dialysis machine Schematic diagram showing the state of the priming solution in the dialysis machine during the circulation process.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification device according to the first embodiment is applied to a blood dialysis device, and as shown in FIG. 1, an arterial blood circuit 2 and a venous blood circuit 3 are connected to a dialyzer 1 as a blood purification means. Mainly from the dialysis apparatus main body B having the dialysate introduction line L1 and the dialysate discharge line L2, the priming solution supply line La, the bubble detection sensor 16 as the bubble detection means, and the control means 17. It is configured in.

The dialyzer 1 contains a blood purification membrane (not shown in the present embodiment, which is a hollow thread type hemodialysis filtration membrane, but includes a flat membrane type hemodialysis membrane or a hemofiltration membrane) to introduce blood. A blood introduction port 1a and a blood outlet 1b for drawing out the introduced blood are formed, and a dialysate introduction port 1c for introducing the dialysate and a dialysate discharge port 1d for discharging the introduced dialysate are formed. , The dialysate is brought into contact with the blood introduced from the blood introduction port 1a via the hollow thread membrane to purify the blood.

The arterial blood circuit 2 is mainly composed of a flexible tube, one end of which is connected to the blood inlet 1a of the dialyzer 1 to guide blood collected from a patient's blood vessel into the hollow fiber membrane of the dialyzer 1. A connector a to which an arterial puncture needle (not shown) can be attached is formed at the other end of the arterial blood circuit 2, and an arterial air trap chamber 5 for defoaming is connected in the middle of the connector a. , Blood pump 4 is arranged. The blood pump 4 is an ironing type pump (a structure that squeezes a flexible tube when rotated in the normal direction to allow blood to flow from the arterial side puncture needle side toward the blood introduction port 1a of the dialyzer 1). ..

Like the arterial blood circuit 2, the venous blood circuit 3 is mainly composed of a flexible tube, one end of which is connected to the blood outlet 1b of the dialyzer 1 to lead out blood that has passed through the hollow fiber membrane. is there. A connector b to which a venous puncture needle (not shown) can be attached is formed at the other end of the venous blood circuit 3, and a venous air trap chamber 6 for defoaming is connected in the middle. .. That is, the blood of the patient collected by the arterial puncture needle reaches the dialyzer 1 via the arterial blood circuit 2, and after the blood is purified, flows through the venous blood circuit 3 and passes through the venous puncture needle. It is designed to return to the patient's body, which allows extracorporeal circulation.

Further, a bubble detection sensor 16 (bubble detection means) is attached between the clamp means Vb in the vein side blood circuit 3 and the vein side air trap chamber 6. The bubble detecting means 16 includes a sensor capable of detecting bubbles (air) in a liquid flowing through a blood circuit, and includes, for example, a pair of ultrasonic vibrating elements (oscillating means and receiving means) made of a piezoelectric element. Has been done.

Specifically, ultrasonic waves can be radiated from an ultrasonic vibrating element as an oscillating means toward a flexible tube constituting a blood circuit (venous blood circuit 3), and the vibration is received as an ultrasonic wave as a receiving means. It can be received by the receiving element. The ultrasonic wave receiving element that has received this vibration is configured so that the voltage changes according to the vibration, and detects that bubbles in the liquid have flowed because the detected voltage exceeds a predetermined threshold value. It is configured to get.

A clamping means Va that can open and close the flow path is connected to the tip side of the arterial blood circuit 2 (between the connector a and the blood pump 4 and in the vicinity of the connector a), and the venous blood circuit 3 A clamping means Vb capable of opening and closing the flow path is connected to the tip side (between the connector b and the vein side air trap chamber 6 and in the vicinity of the connector b). Further, an overflow line Lb extends from the upper part of the venous side air trap chamber 6 formed in the middle of the venous side blood circuit 3, and a clamping means capable of opening and closing the flow path in the middle of the overflow line Lb. Vd is connected.

Therefore, before the dialysis treatment, as shown in FIG. 1, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected, and these arteries are connected. A closed circuit on the blood circuit side can be formed by the side blood circuit 2 and the venous blood circuit 3 (including the blood flow path through which blood flows in the dialyzer 1). Then, by supplying the dialysate as the priming solution into the closed circuit via the priming solution supply line La, the blood circuits (arterial side blood circuit 2 and venous side blood circuit 3) are filled with the dialysate. It is possible to perform priming work. In the process of priming work, the dialysate can be overflowed from the overflow line Lb to clean the inside of the closed circuit on the blood circuit side.

Further, in the venous air trap chamber 6, the pressure of the air layer formed on the upper side is detected during extracorporeal circulation of blood by the blood circuit, and the hydraulic pressure (venous pressure) in the venous blood circuit 3 is detected. The venous pressure sensor 13 to obtain is attached. Then, when the blood purification treatment is started and the patient's blood is circulated extracorporeally in the blood circuit, the venous pressure detected by the venous pressure sensor 13 can be monitored.

The ends of the dialysate introduction line L1 and the dialysate discharge line L2 are connected to the dialysate introduction port 1c and the dialysate discharge port 1d of the dialyzer 1, respectively, and are connected to the dialyzer 1 via the dialysate introduction line L1. The introduced dialysate is configured to pass outside the hollow fiber membrane and be discharged from the dialysate discharge line L2. As described above, the inside of the hollow fiber membrane (purifying membrane) in the dialyzer 1 forms a blood flow path through which blood can flow, and the outside of the hollow fiber membrane forms a dialysate flow path through which dialysate can flow. It is supposed to be.

Further, a double pump 7 for introducing the dialysate into the dialyzer 1 via the dialysate introduction line L1 and discharging the dialysate from the dialyzer 1 is arranged in the dialyzer main body B. The dialysing apparatus main body B has a dialysate introduction line L1 and a dialysate discharge line L2, and also has a double pump 7, bypass lines L3 to L6, and solenoid valves V1 to V7. Of these, the dual pump 7 is arranged across the dialysate introduction line L1 and the dialysate discharge line L2, and introduces the dialysate prepared to a predetermined concentration into the dialyzer 1 and the dialysate after dialysation from the dialyzer 1. Is to be discharged.

A solenoid valve V1 is connected in the middle of the dialysate introduction line L1 (downstream side (dialyzer 1 side) from the connection portion with the priming liquid supply line La in the dialysate introduction line L1), and the dialysate discharge line L2. A solenoid valve V2 is connected on the way (on the upstream side (dialyzer 1 side) of the connection portion with the bypass line L3 in the dialysate discharge line L2). Further, filtration filters 8 and 9 are connected between the double pump 7 and the solenoid valve V1 in the dialysate introduction line L1.

The filtration filters 8 and 9 are for filtering and purifying the dialysate flowing through the dialysate introduction line L1, and the filtration filters 8 and 9 bypass the dialysate discharge line L2 to guide the dialysate. Bypass lines L3 and L4 for dialysis are connected respectively. Solenoid valves V3 and V4 are connected to the bypass lines L3 and L4, respectively. A solenoid valve V6 is connected between the filtration filter 8 and the filtration filter 9 in the dialysate introduction line L1.

On the other hand, a hydraulic pressure measuring sensor 12 capable of measuring the hydraulic pressure of the dialysate is attached between the connecting portion with the bypass line L3 and the connecting portion with the bypass line L4 in the dialysate discharge line L2. Further, bypass lines L5 and L6 that bypass the drainage side of the dual pump 7 are connected to the dialysate discharge line L2, respectively, and the bypass line L5 removes water from the blood of the patient flowing through the dialyzer 1. A water removal pump 10 is provided for this purpose, and a solenoid valve V5 capable of opening and closing the flow path is connected to the bypass line L6.

Further, on the upstream side of the double pump 7 in the dialysate discharge line L2 (between the connecting portion with the bypass line L5 and the double pump 7), pressurization for adjusting the hydraulic pressure on the drainage side of the double pump 7 is performed. The pump 14 is arranged. Further, a degassing chamber 15 is connected to the upstream side (between the pressurizing pump 14 and the dual pump 7) of the dialysate discharge line L2 from the double pump 7, and a check valve or the like is connected to the degassing chamber 15. The atmosphere opening line L7 is connected to the atmosphere opening line L7, and the electromagnetic valve V7 is connected to the atmosphere opening line L7.

One end of the priming solution supply line La is connected to a collection port 11 (so-called sampling port) formed in the dialysate introduction line L1, and the other end is an arterial blood circuit 2 (or a venous blood circuit 3). It is connected to (may be) and consists of a flow path capable of supplying the dialysate of the dialysate introduction line L1 to the arterial blood circuit 2 (or the venous blood circuit 3) as a priming fluid. A clamp means Vc capable of opening and closing the flow path is provided in the priming liquid supply line La, and by opening the clamp means Vc at the time of priming the blood circuit, the clamp means Vc is opened via the priming liquid supply line La. The dialysate can be supplied and filled in the blood circuit.

The control means 17 is composed of, for example, a microcomputer or the like arranged in the main body B of the dialysis apparatus, and controls the opening and closing of arbitrary solenoid valves V1 to V7 and the drive or stop of arbitrary actuators such as the compound pump 7 and the blood pump 4. The hydraulic pressure measurement sensor 12, the venous pressure sensor 13, the bubble detection sensor 16 (bubble detection means), and the like are electrically connected. Further, in the present embodiment, a priming solution (dialysis solution) can be supplied to the blood circuit to perform priming of the blood circuit, and a connection confirmation step for confirming the quality of the connection of the blood circuit is performed. It is supposed to be possible.

Here, the control means 17 according to the present embodiment applies a negative pressure to the blood circuit on condition that the blood circuit is filled with the priming solution (dialysate solution), and the bubble detection sensor 16 is used. It is possible to determine whether or not air bubbles have been detected and perform a connection confirmation step. In particular, the control means 17 according to the present embodiment can apply a negative pressure to the blood circuit by making the dialysate flow (gas purge) in the dialysate flow path formed in the dialyzer 1 while creating a negative pressure. It is configured.

Further, the control means 17 according to the present embodiment includes a priming liquid filling step (overflow step and liquid feeding step) for filling the blood circuit with the priming liquid (dialysate), and the priming filled in the priming liquid filling step. The priming can be performed by sequentially performing the circulation washing step of circulating the liquid in the blood circuit, and the connection confirmation step is performed at the time of the circulation washing step.

Hereinafter, the control content of the control means 17 according to the present embodiment will be described with reference to the flowchart of FIG. 2 and FIGS. 3 to 7.
First, before dialysis treatment (before priming), as shown in FIG. 1, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected. A closed circuit on the blood circuit side is formed by the arterial side blood circuit 2 and the venous side blood circuit 3 (including the flow path through which blood flows in the dialyzer 1).

After that, the connection of the blood circuit is confirmed (S1) by pressurizing the inside of the blood circuit. In such S1, as shown in FIG. 3, the clamping means (Va, Vd) on the blood circuit side is closed and the clamping means (Vb, Vc) is opened, and the solenoid valve (Va, Vc) on the dialysis apparatus main body B side ( V1, V2, V4, V7) are closed and the solenoid valves (V3, V5, V6) are open. Then, by driving the compound pump 7 while driving the blood pump 4 in the forward rotation (rotational direction in which the blood flows during blood purification treatment), the dialysate of the dialysate introduction line L1 is brought into blood via the priming solution supply line La. It is supplied into the circuit and pressurizes the blood circuit.

After the blood pump 4 is driven to rotate forward for a set flow rate or time, the blood pump 4 is stopped and the venous pressure sensor 13 detects the hydraulic pressure in the blood circuit, and the detected value does not exceed a predetermined threshold value. In that case, it is determined that there is an unconnected part and notified. Further, even if the hydraulic pressure detected by the venous pressure sensor 13 exceeds a predetermined threshold value, if the detected value is not held for a predetermined time (for example, 2 seconds), it is determined that there is an unconnected portion and notified. To do.

After confirming the connection of the blood circuit in S1, the process proceeds to S2, and the blood circuit is primed (see FIGS. 4 and 5). In such priming, as shown in FIG. 4, the clamp means (Va to Vd) on the blood circuit side are opened, and the solenoid valves (V1 to V4, V7) on the dialysis machine body B side are closed and electromagnetic. The valves (V5, V6) are opened. Then, by driving the compound pump 7 while stopping the blood pump 4, the dialysate of the dialysate introduction line L1 is supplied as the priming solution to the venous blood circuit 3 side via the priming solution supply line La, and overflows. Overflow from line Lb. This step constitutes an overflow step in the priming liquid filling step.

When the priming solution is supplied to the venous side blood circuit 3 side for a predetermined time or at a predetermined flow rate, the clamping means (Vc, Vd) on the blood circuit side is closed and the clamping means (Va, Vb) is closed as shown in FIG. ) Is in the open state, the solenoid valves (V1, V2, V4, V7) on the B side of the dialysis machine body are in the closed state, and the solenoid valves (V3, V5, V6) are in the open state. Then, by driving the compound pump 7 while driving the blood pump 4 in the reverse direction (the direction of rotation opposite to the direction in which the blood flows during blood purification treatment), the dialysate introduction line L1 is driven via the priming liquid supply line La. The dialysate is supplied as a priming solution to the arterial blood circuit 2 side, and the air in the dialyzer 1 is moved to the venous blood circuit 3 side. This step constitutes the liquid feeding step in the priming liquid filling step.

In such a liquid feeding step (see FIG. 5), when the blood pump 4 drives a predetermined flow rate after the bubble detection sensor 16 detects bubbles (air), the overflow step (see FIG. 4) is performed again. In this way, the overflow step and the liquid feeding step are alternately repeated, and when the steps are performed a predetermined number of times, the priming S2 of the blood circuit is completed and the process proceeds to S3. As shown in FIG. 6, S3 is a step for starting a circulation washing step of circulating the priming liquid in the blood circuit by driving the blood pump 4 in the forward rotation.

In such a circulation washing step, as shown in the figure, the clamping means (Vc, Vd) on the blood circuit side is closed and the clamping means (Va, Vb) is opened, and the electromagnetic wave on the dialysis apparatus main body B side. The valves (V3, V4) are closed and the solenoid valves (V1, V2, V5 to V7) are opened. Then, by driving the compound pump 7 while driving the blood pump 4 in the forward rotation, the dialysate is made to flow (gas purge) in the dialysate flow path in the dialyzer 1 while circulating the priming liquid in the blood circuit.

Here, in the circulation cleaning step, the solenoid valve V7 of the atmosphere opening line L7 and the solenoid valve V5 of the bypass line L6 are opened while the dialysate is flowing through the dialysate flow path in the dialyzer 1, so that the dialysate is opened. A negative pressure is applied to the blood circuit through the flow path, and the process proceeds to S4 to confirm the connection of the blood circuit to determine whether or not the bubble is detected by the bubble detection sensor 16. That is, since the blood circuit has a negative pressure, if there is a connection failure at any part of the blood circuit, air is sucked from the connection failure part to generate air bubbles. Therefore, air bubbles are generated through the connection confirmation step S4. By monitoring the air bubbles with the detection sensor 16, it is possible to confirm the presence or absence of a connection failure.

Then, when it is determined that the bubble is detected in S4, the process proceeds to S5 to generate an alarm for the surroundings to grasp the connection failure. Such an alarm displays a warning on the liquid crystal monitor or the like of the dialysis apparatus main body B, generates a warning sound from a speaker attached to the dialysis apparatus main body B, and lights or blinks a warning light extending upward from the dialysis apparatus main body B. It may be in any form such as letting.

After it is determined that no air bubbles are detected in S4 or an alarm is generated in S5, the process proceeds to S6, and cleaning in the circuit is continued. In the in-circuit cleaning step S6, as shown in FIG. 7, the clamp means (Va to Vd) on the blood circuit side are opened, and the solenoid valves (V1 to V4, V7) on the dialysis apparatus main body B side are closed. The state and the solenoid valves (V5, V6) are opened. Then, by driving the compound pump 7 while driving the blood pump 4 in the forward rotation, the dialysate as the priming solution is supplied and circulated in the blood circuit. This completes a series of controls including priming.

According to the present embodiment, on condition that the blood circuit is filled with the priming liquid, a negative pressure is applied to the blood circuit and whether bubbles are detected by the bubble detection sensor 16 (bubble detection means). Since it is determined whether or not the blood circuit is connected and the blood circuit connection confirmation step is performed, the connection confirmation step for confirming the quality of the blood circuit connection can be performed in a shorter time and with high accuracy. Further, the bubble detection sensor 16 detects bubbles and circulates extracorporeally when blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned from the blood circuit to the patient and returned to the patient after blood purification treatment. Since it is possible to stop or end the return of blood and blood, it is possible to combine the function of preventing air bubbles from being mixed into the patient and the function of confirming the connection.

Further, since a negative pressure can be applied to the blood circuit by applying a negative pressure while flowing the dialysate in the dialysate flow path formed in the dialyzer 1 (blood purification means), dialysis is performed in the dialysate flow path. The connection confirmation step can be performed by utilizing the phenomenon that a negative pressure is generated during the gas purging step of filling the liquid. That is, in the gas purging step, in order to prevent the double pump 7 from sucking the bubbles discharged from the dialysate flow path in the dialyzer 1, the degassing chamber 15 captures the bubbles and the solenoid valve V7 is used. It is configured to discharge air bubbles to the outside from the atmospheric opening line L7 in the open state, and at that time, a phenomenon occurs in which a negative pressure is applied to the blood circuit via the dialysate flow path. According to the present embodiment, this phenomenon can be used to apply negative pressure to the blood circuit during the connection confirmation step. If only the solenoid valve V7 is opened, an excessive negative pressure is generated on the blood circuit side due to the influence of the pressurizing pump 14. Therefore, in the present embodiment, the solenoid valve V5 is opened and the bypass line L6 that bypasses the pressurizing pump 14 is opened to the atmosphere to avoid excessive negative pressure.

Further, according to the present embodiment, a priming liquid filling step of filling the blood circuit with the priming liquid and a circulation washing step of circulating the priming liquid filled in the priming liquid filling step in the blood circuit are sequentially performed. In addition, since the connection confirmation step is performed during the circulation cleaning step, the connection confirmation step can be satisfactorily performed in the circulation cleaning step of the priming process of the blood circuit.

Next, the blood purification apparatus according to the second embodiment of the present invention will be described.
The blood purification device according to the present embodiment is applied to the blood dialysis device as in the first embodiment, and as shown in FIG. 8, the dialyzer 1 as the blood purification means has the arterial blood circuit 2 and the blood purification device. A blood circuit to which the venous blood circuit 3 is connected, a dialyzer main body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming solution supply line La, and a bubble detection sensor (16a) as a bubble detection means. , 16b) and the control means 17 mainly. The same components as those in the first embodiment are designated by the same reference numerals, and the description thereof will be omitted.

In the present embodiment, a plurality of bubble detection sensors (16a, 16b) are arranged in the blood circuit (two in the present embodiment), and bubbles can be detected at a plurality of locations (two locations in the present embodiment). At the same time, it is configured so that a connection failure location can be identified according to the bubble detection sensor (16a, 16b) in which bubbles are detected. Specifically, the bubble detection sensor (16a, 16b) can detect bubbles in the liquid flowing in the blood circuit as in the previous embodiment, and the bubble detection sensor 16a is the arterial blood circuit 2. It is attached to the tip (between the connection with the priming liquid supply line La and the clamping means Va), and the bubble detection sensor 16b is attached to the tip of the venous blood circuit 3 (the venous air trap chamber 6 and the clamping means Vb). Is attached to the space).

Hereinafter, the control content of the control means 17 according to the present embodiment will be described with reference to the flowchart of FIG. 9 and FIG.
First, before dialysis treatment (before priming), as shown in FIG. 8, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected. A closed circuit on the blood circuit side is formed by the arterial side blood circuit 2 and the venous side blood circuit 3 (including the flow path through which blood flows in the dialyzer 1).

Then, after confirming the connection of the blood circuit by pressurization (S1) and priming the blood circuit (S2), the process proceeds to S3 to start the circulation washing step. The blood circuit connection confirmation (S1) and the blood circuit priming (S2) are the same as those in the first embodiment, and thus the description thereof will be omitted. As shown in FIG. 10, S3 is a step for starting a circulation washing step of circulating the priming liquid in the blood circuit by driving the blood pump 4 in the forward rotation.

In such a circulation washing step, as shown in the figure, the clamping means (Vc, Vd) on the blood circuit side is closed and the clamping means (Va, Vb) is opened, and the electromagnetic wave on the dialysis apparatus main body B side. The valves (V3, V4) are closed and the solenoid valves (V1, V2, V5 to V7) are opened. Then, by driving the compound pump 7 while driving the blood pump 4 in the forward rotation, the dialysate is made to flow (gas purge) in the dialysate flow path in the dialyzer 1 while circulating the priming liquid in the blood circuit.

In the circulation cleaning step, as in the first embodiment, the solenoid valve V7 of the atmosphere opening line L7 and the solenoid valve V5 of the bypass line L6 are opened while flowing the dialysate through the dialysate flow path in the dialyzer 1. Therefore, negative pressure is applied to the blood circuit via the dialysate flow path, and the blood proceeds to S4 and S5 to determine whether or not bubbles are detected by the bubble detection sensors (16a and 16b). The circuit connection confirmation process is performed. That is, since the blood circuit has a negative pressure, if there is a connection failure at any part of the blood circuit, air is sucked from the connection failure part and bubbles are generated. Therefore, the connection confirmation step (S4, S5). ), And by monitoring the air bubbles with the air bubble detection sensors (16a, 16b), it is possible to confirm the presence or absence of a connection failure.

In the present embodiment, it is determined in S4 that either the bubble detection sensor 16a or the bubble detection sensor 16b detects bubbles, and the bubble detection sensor 16b detects bubbles before the bubble detection sensor bubbles 16a. Then, the process proceeds to S6, and an alarm is generated to let the surroundings know the connection failure. Such an alarm displays a warning on the liquid crystal monitor or the like of the dialysis apparatus main body B, generates a warning sound from a speaker attached to the dialysis apparatus main body B, and lights or blinks a warning light extending upward from the dialysis apparatus main body B. It may be in any form such as letting.

Here, in the present embodiment, after the above alarm is issued in S6, the process proceeds to S7, and the connection failure is at a position downstream of the bubble detection sensor 16a (position upstream of the bubble detection sensor 16b). To identify. That is, since the blood pump 4 is driven in the forward rotation, if there is a connection failure at the position, the bubbles sucked from the connection failure location are detected by the bubble detection sensor 16b and then by the bubble detection sensor 16a. Since it will be detected, it is possible to identify the connection failure location according to the detection order.

On the other hand, if it is determined in S4 that no air bubbles are detected, the process proceeds to S5. When it is determined in S5 that either one of the bubble detection sensor 16a or the bubble detection sensor 16b detects a bubble and the bubble detection sensor 16a detects a bubble before the bubble detection sensor bubble 16b, the process proceeds to S8. , Generates an alarm to let the surroundings know the connection failure. Such an alarm displays a warning on the liquid crystal monitor or the like of the dialysis apparatus main body B, generates a warning sound from a speaker attached to the dialysis apparatus main body B, and lights or blinks a warning light extending upward from the dialysis apparatus main body B. It may be in any form such as letting.

Here, in the present embodiment, after the above alarm is issued in S8, the process proceeds to S9, and the connection failure is at a position downstream of the bubble detection sensor 16b (position upstream of the bubble detection sensor 16a). To identify. That is, since the blood pump 4 is driven in the forward rotation, if there is a connection failure at the position, the bubbles sucked from the connection failure location are detected by the bubble detection sensor 16a and then by the bubble detection sensor 16b. Since it will be detected, it is possible to identify the connection failure location according to the detection order.

If it is determined in S5 that no air bubbles are detected, or if a connection failure is identified by S7 and S9, the process proceeds to S10 to perform the in-circuit cleaning step. Since the in-circuit cleaning step S10 is the same as that of the first embodiment (see FIG. 7), the description thereof will be omitted. This completes a series of controls including priming.

According to the present embodiment, as in the first embodiment, on the condition that the blood circuit is filled with the priming liquid, a negative pressure is applied to the blood circuit and the bubble detection sensors (16a, 16b) are applied. Since the blood circuit connection confirmation step is performed by determining whether or not bubbles have been detected by (bubble detection means), the connection confirmation step for confirming the quality of the blood circuit connection can be performed in a shorter time and with higher accuracy. Can be done. Further, the bubble detection sensor 16 detects bubbles and circulates extracorporeally when blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned from the blood circuit to the patient and returned to the patient after blood purification treatment. Since it is possible to stop or end the return of blood and blood, it is possible to combine the function of preventing air bubbles from being mixed into the patient and the function of confirming the connection.

In particular, according to the present embodiment, a plurality of bubble detection sensors (16a, 16b) can be arranged in the blood circuit to detect bubbles at a plurality of locations, and the bubble detection sensors (16a, 16b) in which bubbles are detected can be detected. ), Since the connection failure location can be identified, it is possible to take measures after the connection failure is confirmed more quickly and smoothly. In the present embodiment, the bubble detection sensors (16a, 16b) are arranged at the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3, respectively, but three or more are arranged at other sites. The bubble detection sensor may be arranged so that a poor connection location can be identified according to the bubble detection sensor in which bubbles are detected.

Next, the blood purification apparatus according to the third embodiment of the present invention will be described.
The blood purification device according to the present embodiment is applied to the blood dialysis device as in the first embodiment, and as shown in FIG. 1, the dialyzer 1 as the blood purification means has the arterial blood circuit 2 and the blood purification device. A blood circuit to which the venous blood circuit 3 is connected, a dialyzer main body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming solution supply line La, and a bubble detection sensor 16 as a bubble detection means. , Mainly composed of the control means 17. That is, the device configuration is the same as that of the first embodiment.

Hereinafter, the control content of the control means 17 according to the present embodiment will be described with reference to the flowchart of FIG. 11 and FIGS. 12 and 13.
First, before dialysis treatment (before priming), as shown in FIG. 1, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected. A closed circuit on the blood circuit side is formed by the arterial side blood circuit 2 and the venous side blood circuit 3 (including the flow path through which blood flows in the dialyzer 1).

After that, the connection of the blood circuit is confirmed by pressurization (S1) and the priming of the blood circuit is performed (S2), and then the process proceeds to S3 to apply a negative pressure to the blood circuit. The blood circuit connection confirmation (S1) and the blood circuit priming (S2) are the same as those in the first embodiment, and thus the description thereof will be omitted. As shown in FIG. 12, S3 applies negative pressure to the blood circuit by driving the blood pump 4 in the reverse rotation while closing a predetermined position of the blood circuit (the position of the clamp means Va in the present embodiment). It is configured to get.

Specifically, as shown in the figure, the clamp means (Va, Vc, Vd) on the blood circuit side is closed and the clamp means Vb is open, and the solenoid valve (V1, V1) on the dialysis machine body B side. V2, V4, V7) is closed and the solenoid valves (V3, V5, V6) are open. Then, by driving the compound pump 7 while driving the blood pump 4 in the reverse rotation, a negative pressure is formed in the blood circuit. Since the blood circuit has a negative pressure, if there is a connection failure at any part of the blood circuit, air is sucked from the connection failure part and bubbles are generated.

After that, the process proceeds to S4 to circulate the priming solution in the blood circuit. In S4, as shown in FIG. 13, the clamp means (Vc, Vd) on the blood circuit side is in the closed state and the clamp means (Va, Vb) is in the open state, and the solenoid valve (V1, Vb) on the dialysis apparatus main body B side is set. V2, V4, V7) is closed and the solenoid valves (V3, V5, V6) are open. Then, the priming liquid is circulated in the blood circuit by driving the compound pump 7 while driving the blood pump 4 in the forward rotation.

After S4, the process proceeds to S5, and a blood circuit connection confirmation step of determining whether or not a bubble is detected by the bubble detection sensor 16 is performed. That is, if there is a connection failure at any part of the blood circuit, air is sucked from the connection failure part in S3 to generate air bubbles. Therefore, the air bubbles are monitored by the bubble detection sensor 16 through the connection confirmation step S5. This makes it possible to confirm the presence or absence of poor connection.

Then, when it is determined that the bubble is detected in S5, the process proceeds to S6 to generate an alarm for the surroundings to grasp the connection failure. Such an alarm displays a warning on the liquid crystal monitor or the like of the dialysis apparatus main body B, generates a warning sound from a speaker attached to the dialysis apparatus main body B, and lights or blinks a warning light extending upward from the dialysis apparatus main body B. It may be in any form such as letting.

After it is determined in S5 that no air bubbles are detected or after an alarm is generated in S6, the circulation cleaning S7 and the in-circuit cleaning S8 are continuously performed. Since the circulation cleaning S7 (see FIG. 6) and the in-circuit cleaning S8 (see FIG. 7) are the same as those in the first embodiment, the description thereof will be omitted. This completes a series of controls including priming.

According to the present embodiment, on condition that the blood circuit is filled with the priming liquid, a negative pressure is applied to the blood circuit and whether bubbles are detected by the bubble detection sensor 16 (bubble detection means). Since it is determined whether or not the blood circuit is connected and the blood circuit connection confirmation step is performed, the connection confirmation step for confirming the quality of the blood circuit connection can be performed in a shorter time and with high accuracy. Further, the bubble detection sensor 16 detects bubbles and circulates extracorporeally when blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned from the blood circuit to the patient and returned to the patient after blood purification treatment. Since it is possible to stop or end the return of blood and blood, it is possible to combine the function of preventing air bubbles from being mixed into the patient and the function of confirming the connection.

In particular, according to the present embodiment, the blood pump 4 arranged in the arterial blood circuit 2 is driven while closing a predetermined position of the blood circuit (arrangement position of the clamping means Va) with the clamping means Va closed (the position where the clamping means Va is arranged). Since negative pressure can be applied to the blood circuit by driving the blood circuit in the reverse direction), the connection confirmation step can be easily performed during or after the priming of the blood circuit.

Next, the blood purification apparatus according to the fourth embodiment of the present invention will be described.
The blood purification device according to the present embodiment is applied to the blood dialysis device as in the first embodiment, and as shown in FIGS. 15 to 20, the dialyzer 1 as a blood purification means has an arterial blood circuit. A blood circuit to which 2 and the blood circuit 3 on the venous side are connected, a dialyzer main body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming solution supply line La, and a bubble detection sensor as a bubble detection means. It is mainly composed of 16, a control means 17, and a liquid level adjusting means (18, 19). The same components as those in the first embodiment are designated by the same reference numerals, and the description thereof will be omitted.

The liquid level adjusting means (18, 19) includes an extension tube (18a, 19a) extending from the upper part (air layer) of the arterial side air trap chamber 5 and having an open tip to the atmosphere, and these extension tubes (18a). , 19b), each of which has a liquid level adjusting pump (18b, 19b). The liquid level adjusting pumps (18b, 19b) consist of an ironing type pump capable of forward rotation drive and reverse rotation drive, and by squeezing the extension tube (18a, 19a) toward the longitudinal direction, the arterial side air It is configured so that air can be arbitrarily introduced or discharged from the upper part of the trap chamber 5 or the upper part of the venous air trap chamber 6.

Then, when the liquid level adjusting pumps (18b, 19b) are driven in a forward rotation, air is sucked from the tips of the extension tubes (18a, 19b), so that the arterial side air trap chamber 5 and the venous side air trap chamber 6 Air can be introduced into the vein to lower the liquid level, and when the liquid level adjusting pumps (18b, 19b) are driven in reverse rotation, air is discharged from the tip of the extension tube (18a, 19a). Air can be discharged from the arterial air trap chamber 5 and the venous air trap chamber 6 to raise the liquid level.

Hereinafter, the control content of the control means 17 according to the present embodiment will be described with reference to the flowchart of FIG. 14 and FIGS. 15 to 20.
First, before dialysis treatment (before priming), as shown in FIG. 15, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are left open, and the inside of the blood circuit is pressurized. Have them check the connection of the blood circuit (S1). In such S1, as shown in the figure, the clamping means (Vb, Vc) on the blood circuit side is closed and the clamping means Va is opened, and the solenoid valves (V1 to V7) on the dialysis apparatus main body B side. Is closed.

Then, the liquid level adjusting pumps (18b and 19b) are driven to rotate in the forward direction, respectively, and air is introduced into the arterial side air trap chamber 5 and the vein side air trap chamber 6 from the tips of the extension tubes (18a and 19b). Pressurize the inside of the blood circuit. The blood pump 4 and the compound pump 7 are in a stopped state. After the liquid level adjusting pumps (18b, 19b) are driven in a forward rotation for a set flow rate or time, the liquid level adjusting pumps (18b, 19b) are stopped, respectively, and the venous pressure sensor 13 is used to reduce the liquid pressure in the blood circuit. If it is detected and the detected value does not exceed a predetermined threshold value, it is determined that there is an unconnected part and notified. Further, even if the hydraulic pressure detected by the venous pressure sensor 13 exceeds a predetermined threshold value, if the detected value is not held for a predetermined time (for example, 2 seconds), it is determined that there is an unconnected portion and notified. To do.

After confirming the connection of the blood circuit by pressurizing S1, the process proceeds to S2, and the priming solution supply line La is filled with the priming solution (dialysis solution). In S2, as shown in FIG. 16, the clamp means (Va to Vc) on the blood circuit side are opened, and the solenoid valves (V1 to V4, V7) on the B side of the dialysis machine body are closed and electromagnetic. The valves (V5, V6) are opened. Then, by driving the compound pump 7 while stopping the blood pump 4, the priming solution (dialysis solution) is filled up to the tip of the priming solution supply line La and the arterial side blood circuit 2.

After driving the compound pump 7 for a predetermined time, the process proceeds to S3, and the entire blood circuit is filled with a priming solution (dialysate solution) for priming. In such S3, as shown in FIG. 17, the clamping means Va on the blood circuit side is closed and the clamping means (Vb, Vc) is opened, and the solenoid valves (V1, V2,) on the dialysis apparatus main body B side are opened. V4, V7) is closed and the solenoid valves (V3, V5, V6) are open. Then, by driving the compound pump 7 while driving the blood pump 4 in the forward rotation, the entire blood circuit is filled with the priming solution (dialysate solution). After that, the liquid level adjusting pumps 18 and 19 are appropriately driven to discharge the air in the arterial side air trap chamber 5 and the venous side air trap chamber 6 to fill the priming liquid, and the arterial side air trap chamber 5 and the arterial side air trap chamber 5 and A liquid level is formed in the venous air trap chamber 6.

After the flow rate of the blood pump 4 reaches a predetermined amount, the process proceeds to S4, and gas purging is performed to flow and fill the dialysate flow path of the dialyzer 1. In such S4, as shown in FIG. 18, the clamping means (Va, Vb) on the blood circuit side is closed and the clamping means Vc is opened, and the solenoid valve (V3, V4, on the dialysis machine body B side) is set. V7) is closed and the solenoid valves (V1, V2, V5, V6) are open. Then, by driving the compound pump 7 while driving the blood pump 4 in the forward rotation, the dialysate flows and fills the dialysate flow path of the dialyzer 1.

After driving the compound pump 7 for a predetermined time, the process proceeds to S5 to apply negative pressure to the blood circuit. In such S5, as shown in FIG. 19, the clamp means (Va to Vc) on the blood circuit side are closed, and the solenoid valves (V3, V4) on the dialysis apparatus main body B side are closed and the solenoid valve (V3, V4) is closed. V1, V2, V5, V6, V7) are opened. That is, in S5, the solenoid valve V7 of the atmospheric opening line L7 and the solenoid valve V5 of the bypass line L6 are opened while flowing the dialysate through the dialysate flow path in the dialyzer 1, so that the dialysate flow path is opened. Negative pressure is applied to the blood circuit through the blood circuit.

Then, the process proceeds to S6, and the priming solution is circulated in the blood circuit. In such S6, as shown in FIG. 20, the clamping means Va on the blood circuit side is closed and the clamping means (Vb, Vc) is opened, and the solenoid valves (V1, V2,) on the dialysis apparatus main body B side are opened. V4, V7) is closed and the solenoid valves (V3, V5, V6) are open. In this state, the process proceeds to S7, and the connection confirmation step of the blood circuit for determining whether or not the bubble is detected by the bubble detection sensor 16 is performed. That is, since the blood circuit has a negative pressure in S5, if there is a connection failure at any part of the blood circuit, air is sucked from the connection failure part and bubbles are generated. Therefore, the connection confirmation step S7 By monitoring the air bubbles with the air bubble detection sensor 16 through the above, it is possible to confirm the presence or absence of a connection failure.

Then, when it is determined that the bubble is detected in S7, the process proceeds to S8 to generate an alarm for the surroundings to grasp the connection failure. Such an alarm displays a warning on the liquid crystal monitor or the like of the dialysis apparatus main body B, generates a warning sound from a speaker attached to the dialysis apparatus main body B, and lights or blinks a warning light extending upward from the dialysis apparatus main body B. It may be in any form such as letting. Then, after it is determined in S7 that no air bubbles are detected or after an alarm is generated in S8, a series of controls including priming is terminated.

According to the present embodiment, on condition that the blood circuit is filled with the priming liquid, a negative pressure is applied to the blood circuit and whether bubbles are detected by the bubble detection sensor 16 (bubble detection means). Since it is determined whether or not the blood circuit is connected and the blood circuit connection confirmation step is performed, the connection confirmation step for confirming the quality of the blood circuit connection can be performed in a shorter time and with high accuracy. Further, the bubble detection sensor 16 detects bubbles and circulates extracorporeally when blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned from the blood circuit to the patient and returned to the patient after blood purification treatment. Since it is possible to stop or end the return of blood and blood, it is possible to combine the function of preventing air bubbles from being mixed into the patient and the function of confirming the connection.

Further, since a negative pressure can be applied to the blood circuit by applying a negative pressure while flowing the dialysate in the dialysate flow path formed in the dialyzer 1 (blood purification means), dialysis is performed in the dialysate flow path. The connection confirmation step can be performed by utilizing the phenomenon that a negative pressure is generated during the gas purging step of filling the liquid. That is, in the gas purging step, in order to prevent the double pump 7 from sucking the bubbles discharged from the dialysate flow path in the dialyzer 1, the degassing chamber 15 captures the bubbles and the solenoid valve V7 is used. It is configured to be opened and discharge air bubbles to the outside from the atmospheric opening line L7, and at that time, a phenomenon that a negative pressure is applied to the blood circuit via the dialysate flow path occurs. According to the present embodiment, this phenomenon can be used to apply negative pressure to the blood circuit during the connection confirmation step.

Although the present embodiment has been described above, the present invention is not limited to these. For example, the bubble detection sensor 16 applies negative pressure to the blood circuit without confirming the connection of the blood circuit by pressurization. The bubble may be detected. Further, in the connection confirmation step, the means for applying negative pressure to the blood circuit is not limited to the above embodiment, and various means can be used. The priming solution is not limited to the one using a dialysate as in the above embodiment, and may be, for example, a physiological saline solution or another liquid contained in a saline bag.

Further, the bubble detection sensor 16 (bubble detection means) capable of detecting bubbles in the connection confirmation step may be arranged at any site of the blood circuit, for example, a connection site with the dialyzer 1 in the arterial blood circuit 2. It may be arranged in the vicinity (entrance portion to the dialyzer 1) or in the vicinity of the connection site with the dialyzer 1 (outlet portion from the dialyzer 1) in the venous blood circuit 3 to ensure that the connection of the dialyzer 1 is confirmed.

On condition that the blood circuit is filled with the priming solution, negative pressure is applied to the blood circuit, and it is possible to determine whether or not bubbles are detected by the bubble detecting means and perform a connection confirmation step. If it is a purification device and its connection confirmation method, it can be applied to a device having other functions added.

1 ... Dializer (blood purification means)
2 ... Arterial blood circuit 3 ... Venous blood circuit 4 ... Blood pump 5 ... Arterial air trap chamber 6 ... Venous air trap chamber 7 ... Duplex pump 8, 9 ... Filter filter 10 ... Water removal pump 11 ... Collection port 12 ... Hydraulic pressure measurement sensor 13 ... Venous pressure sensor 14 ... Pressurized pump 15 ... Degassing chamber 16 ... Bubble detection sensor (bubble detection means)
17 ... Control means 18, 19 ... Liquid level adjusting means L1 ... Dialysate introduction line L2 ... Dialysate discharge line L7 ... Atmospheric release line La ... Priming liquid supply line Lb Overflow line B ...

Claims (6)

A blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating the patient's blood,
A blood purification means that is connected between the arterial blood circuit and the venous blood circuit and purifies the blood flowing through the blood circuit.
A first bubble detecting means and a second bubble detecting means capable of detecting bubbles in a liquid flowing in the blood circuit, and
A control means capable of supplying a priming solution to the blood circuit to perform priming of the blood circuit and performing a connection confirmation step for confirming the quality of the connection of the blood circuit.
In a blood purification device equipped with
The control means applies negative pressure to the blood circuit on condition that the tip of the arterial blood circuit and the tip of the venous blood circuit are connected and the priming solution is filled in the blood circuit. The control means is configured so that the connection confirmation step can be performed by determining whether or not the blood bubbles have been detected by the bubble detecting means, and the control means has the first bubble detecting means and the second blood bubble detecting means. Among the means, the poorly connected portion is identified based on the bubble detecting means detected earlier , and the control means is the blood disposed in the arterial blood circuit while blocking a predetermined position of the blood circuit. A blood purification device characterized in that the negative pressure can be applied to the blood circuit by driving a pump . The bubble detecting means can be arranged in a plurality of blood circuits to detect bubbles at a plurality of locations, and the control means can identify a poor connection location according to the bubble detecting means in which bubbles are detected. The blood purification apparatus according to claim 1. The control means may sequentially perform a priming liquid filling step of filling the blood circuit with the priming liquid and a circulation washing step of circulating the priming liquid filled in the priming liquid filling step in the blood circuit. The blood purification apparatus according to claim 1 or 2 , wherein the connection confirmation step is performed during the circulation washing step. A blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating the patient's blood,
A blood purification means that is connected between the arterial blood circuit and the venous blood circuit and purifies the blood flowing through the blood circuit.
A first bubble detecting means and a second bubble detecting means capable of detecting bubbles in a liquid flowing in the blood circuit, and
A control means capable of supplying a priming solution to the blood circuit to perform priming of the blood circuit and performing a connection confirmation step for confirming the quality of the connection of the blood circuit.
In the connection confirmation method of the blood purification device equipped with
On the condition that the tip of the arterial blood circuit and the tip of the venous blood circuit are connected and the priming solution is filled in the blood circuit, a negative pressure is applied to the blood circuit and the air bubbles are applied. The detection means determines whether or not a bubble is detected, performs a blood circuit connection confirmation step, and is based on the bubble detecting means previously detected among the first bubble detecting means and the second bubble detecting means. It is characterized in that the negative pressure is applied to the blood circuit by identifying a poorly connected portion and driving a blood pump arranged in the blood circuit on the arterial side while closing a predetermined position of the blood circuit. How to check the connection of the blood purification device. The claim is characterized in that a plurality of bubble detecting means can be arranged in the blood circuit to detect bubbles at a plurality of locations, and can identify a poorly connected portion according to the bubble detecting means in which the bubbles are detected. Item 4. The method for confirming the connection of the blood purification device according to item 4 . The priming liquid filling step of filling the blood circuit with the priming liquid and the circulation washing step of circulating the priming liquid filled in the priming liquid filling step in the blood circuit can be sequentially performed, and the circulation washing can be performed. The connection confirmation method for a blood purification device according to claim 4 or 5 , wherein the connection confirmation step is performed during the process.

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